TR199601036A2 - Osteoprotegerin. - Google Patents
Osteoprotegerin.Info
- Publication number
- TR199601036A2 TR199601036A2 TR96/01036A TR9601036A TR199601036A2 TR 199601036 A2 TR199601036 A2 TR 199601036A2 TR 96/01036 A TR96/01036 A TR 96/01036A TR 9601036 A TR9601036 A TR 9601036A TR 199601036 A2 TR199601036 A2 TR 199601036A2
- Authority
- TR
- Turkey
- Prior art keywords
- osteopetrosis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/577,788 US6613544B1 (en) | 1995-12-22 | 1995-12-22 | Osteoprotegerin |
US08/706,945 US6369027B1 (en) | 1995-12-22 | 1996-09-03 | Osteoprotegerin |
Publications (2)
Publication Number | Publication Date |
---|---|
TR199601036A3 TR199601036A3 (tr) | 1997-07-21 |
TR199601036A2 true TR199601036A2 (tr) | 1997-07-21 |
Family
ID=27077338
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR96/01036A TR199601036A2 (tr) | 1995-12-22 | 1996-12-20 | Osteoprotegerin. |
Country Status (31)
Country | Link |
---|---|
US (1) | US6369027B1 (tr) |
EP (4) | EP0870023A1 (tr) |
JP (1) | JP4657388B2 (tr) |
KR (1) | KR100463584B1 (tr) |
CN (1) | CN1318588C (tr) |
AR (1) | AR004400A1 (tr) |
AT (1) | ATE409745T1 (tr) |
AU (1) | AU710587B2 (tr) |
BG (1) | BG63347B1 (tr) |
CA (1) | CA2210467C (tr) |
CZ (1) | CZ292587B6 (tr) |
DE (1) | DE19654610A1 (tr) |
DK (1) | DK0784093T3 (tr) |
EE (1) | EE04643B1 (tr) |
ES (1) | ES2316152T3 (tr) |
FR (1) | FR2742767B1 (tr) |
GB (1) | GB2312899B (tr) |
HK (1) | HK1001526A1 (tr) |
HU (1) | HU227482B1 (tr) |
IL (1) | IL121520A (tr) |
MX (1) | MX9706193A (tr) |
NO (1) | NO973699L (tr) |
NZ (2) | NZ332915A (tr) |
PL (1) | PL187408B1 (tr) |
PT (1) | PT784093E (tr) |
RO (1) | RO121386B1 (tr) |
SI (1) | SI0784093T1 (tr) |
SK (1) | SK110797A3 (tr) |
TR (1) | TR199601036A2 (tr) |
WO (1) | WO1997023614A1 (tr) |
YU (1) | YU69196A (tr) |
Families Citing this family (85)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6919434B1 (en) | 1995-02-20 | 2005-07-19 | Sankyo Co., Ltd. | Monoclonal antibodies that bind OCIF |
IL117175A (en) * | 1995-02-20 | 2005-11-20 | Sankyo Co | Osteoclastogenesis inhibitory factor protein |
US7078493B1 (en) | 1995-03-15 | 2006-07-18 | Human Genome Sciences, Inc. | Antibodies to human tumor necrosis factor receptor-like genes |
US7005413B1 (en) | 1995-12-22 | 2006-02-28 | Amgen Inc. | Combination therapy for conditions leading to bone loss |
US7632922B1 (en) * | 1995-12-22 | 2009-12-15 | Amgen, Inc. | Osteoprotegerin |
JPH1057071A (ja) * | 1996-08-19 | 1998-03-03 | Snow Brand Milk Prod Co Ltd | 新規dna及びそれを用いた蛋白質の製造方法 |
EP2002846B1 (en) | 1996-12-06 | 2017-01-25 | Amgen Inc. | Combination therapy using an IL-1 inhibitor for treating IL-1 mediated diseases |
US6271349B1 (en) | 1996-12-23 | 2001-08-07 | Immunex Corporation | Receptor activator of NF-κB |
CA2274987C (en) | 1996-12-23 | 2012-01-24 | Immunex Corporation | Ligand for receptor activator of nf-kappa b, ligand is member of tnf superfamily |
DK0911342T4 (da) * | 1997-04-15 | 2013-07-29 | Daiichi Sankyo Co Ltd | Nyt protein og fremgangsmåde til fremstilling deraf |
US6316408B1 (en) * | 1997-04-16 | 2001-11-13 | Amgen Inc. | Methods of use for osetoprotegerin binding protein receptors |
ATE363533T1 (de) | 1997-04-16 | 2007-06-15 | Amgen Inc | Osteoprotegerin bindende proteine und rezeptoren |
CA2288351A1 (en) * | 1997-05-01 | 1998-11-05 | Amgen Inc. | Chimeric opg polypeptides |
AU9013998A (en) * | 1997-07-21 | 1999-02-10 | Zymogenetics Inc. | Tumor necrosis factor receptor ztnfr-5 |
EP1019502A2 (en) * | 1997-08-06 | 2000-07-19 | Regeneron Pharmaceuticals, Inc. | Human orphan receptor ntr-1 |
US6346388B1 (en) | 1997-08-13 | 2002-02-12 | Smithkline Beecham Corporation | Method of identifying agonist and antagonists for tumor necrosis related receptors TR1 and TR2 |
WO1999011790A1 (en) * | 1997-09-04 | 1999-03-11 | Zymogenetics, Inc. | Tumor necrosis factor receptor ztnfr-6 |
PT1015587E (pt) | 1997-09-18 | 2008-07-31 | Genentech Inc | Polipéptido dcr3, um homólogo de tnfr |
CA2269114A1 (en) * | 1997-09-24 | 1999-03-24 | Snow Brand Milk Products Co., Ltd. | Method for diagnosis of metabolic bone diseases |
US6087555A (en) * | 1997-10-15 | 2000-07-11 | Amgen Inc. | Mice lacking expression of osteoprotegerin |
JPH11155420A (ja) * | 1997-12-02 | 1999-06-15 | Snow Brand Milk Prod Co Ltd | トランスジェニック動物 |
WO1999031128A2 (en) * | 1997-12-16 | 1999-06-24 | Incyte Pharmaceuticals, Inc. | Human tumor necrosis factor-r2-like proteins |
US6077689A (en) * | 1997-12-24 | 2000-06-20 | Amgen Inc. | Enhanced solubility of recombinant proteins |
CA2321105A1 (en) * | 1998-02-17 | 1999-08-19 | Incyte Pharmaceuticals, Inc. | Human short-chain tnf-receptor family protein |
US6103472A (en) * | 1998-02-20 | 2000-08-15 | Amgen Inc. | Methods and compositions for identifying novel secreted mammalian polypeptides in yeast |
US6150098A (en) * | 1998-02-20 | 2000-11-21 | Amgen Inc. | Methods for identifying novel secreted mammalian polypeptides |
DE69940058D1 (de) | 1998-04-23 | 2009-01-22 | Ajinomoto Kk | Stoff mit antithrombotischer aktivität und verfahren zur bestimmung von glycokallidin |
US6790823B1 (en) | 1998-04-23 | 2004-09-14 | Amgen Inc. | Compositions and methods for the prevention and treatment of cardiovascular diseases |
ES2317694T3 (es) | 1998-05-14 | 2009-04-16 | Immunex Corporation | Metodo para inhibir la actividad osteoclastica. |
US6210924B1 (en) | 1998-08-11 | 2001-04-03 | Amgen Inc. | Overexpressing cyclin D 1 in a eukaryotic cell line |
PL196790B1 (pl) * | 1998-09-15 | 2008-01-31 | Pharmexa As | Zastosowanie zwierzęcego polipeptydu OPGL lub jego podsekwencji, lub analogu OPGL, zastosowanie fragmentu kwasu nukleinowego, zastosowanie wektora przenoszącego fragment kwasu nukleinowego, zastosowanie niepatogennej transformowanej komórki, zastosowanie kompozycji zawierającej taki fragment lub wektor, sposób identyfikacji zmodyfikowanego polipeptydu OPGL, sposób wytwarzania kompozycji immunogennej |
US6420339B1 (en) | 1998-10-14 | 2002-07-16 | Amgen Inc. | Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility |
US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
MY126795A (en) | 1998-10-23 | 2006-10-31 | Amgen K A Inc | Dimeric thrombopoietic peptide mimetics binding to mp1 receptor and having thrombopoietic activity. |
US7488590B2 (en) | 1998-10-23 | 2009-02-10 | Amgen Inc. | Modified peptides as therapeutic agents |
RU2223782C2 (ru) * | 1998-10-28 | 2004-02-20 | Санкио Компани, Лимитед | Средство для лечения патологического костного метаболизма |
US6245740B1 (en) | 1998-12-23 | 2001-06-12 | Amgen Inc. | Polyol:oil suspensions for the sustained release of proteins |
JP2005517379A (ja) * | 1999-01-18 | 2005-06-16 | オステオミーター・ビオテク・エー/エス | 遺伝的疾病素因 |
US20030007972A1 (en) * | 1999-02-24 | 2003-01-09 | Edward Tobinick | Cytokine antagonists and other biologics for the treatment of bone metastases |
US7259253B2 (en) * | 1999-05-14 | 2007-08-21 | Quark Biotech, Inc. | Genes associated with mechanical stress, expression products therefrom, and uses thereof |
AU6078500A (en) * | 1999-07-09 | 2001-01-30 | Amgen, Inc. | Combination therapy for conditions leading to bone loss |
AUPQ167599A0 (en) * | 1999-07-19 | 1999-08-12 | St. Vincent's Institute Of Medical Research | Inhibitor of osteoclast precursor formation |
IL130989A0 (en) | 1999-07-20 | 2001-01-28 | Compugen Ltd | Variants of alternative splicing |
US6673771B1 (en) * | 1999-07-28 | 2004-01-06 | The Trustees Of The University Of Pennsylvania | Methods of inhibiting osteoclast activity |
US8106098B2 (en) | 1999-08-09 | 2012-01-31 | The General Hospital Corporation | Protein conjugates with a water-soluble biocompatible, biodegradable polymer |
AU6946300A (en) * | 1999-08-30 | 2001-03-26 | Mayo Foundation For Medical Education And Research | Use of dna encoding osteoprotegerin to prevent or inhibit metabolic bone disorders |
AU2005237128B2 (en) * | 1999-09-03 | 2008-09-11 | Amgen Inc. | Compositions and Methods for the Prevention or Treatment of Cancer and Bone Loss Associated with Cancer |
JP2003508491A (ja) * | 1999-09-03 | 2003-03-04 | アムジエン・インコーポレーテツド | 癌および癌に関連する骨損失の予防または治療のための組成物および方法 |
US20030144187A1 (en) * | 1999-09-03 | 2003-07-31 | Colin R. Dunstan | Opg fusion protein compositions and methods |
US6808902B1 (en) * | 1999-11-12 | 2004-10-26 | Amgen Inc. | Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules |
EP1238077A1 (en) * | 1999-12-16 | 2002-09-11 | Amgen Inc., | Tnfr/opg-like molecules and uses thereof |
US20030103978A1 (en) | 2000-02-23 | 2003-06-05 | Amgen Inc. | Selective binding agents of osteoprotegerin binding protein |
JP2004519205A (ja) | 2000-06-28 | 2004-07-02 | アムジェン インコーポレイテッド | 胸腺間質リンホポイエチンレセプター分子およびその使用 |
JP4854174B2 (ja) * | 2000-09-22 | 2012-01-18 | イミュネックス・コーポレーション | NF−κBの受容体活性化剤のアゴニストまたはアンタゴニストのスクリーニングアッセイ法 |
WO2002064782A2 (en) * | 2001-02-09 | 2002-08-22 | Maxygen Holdings Ltd. | Rank ligand-binding polypeptides |
AU2002253133B2 (en) | 2001-04-03 | 2008-02-28 | Societe Des Produits Nestle S.A. | Osteoprotegerin in milk |
WO2002098362A2 (en) * | 2001-06-06 | 2002-12-12 | Immunex Corporation | Use of rank antagonists to treat cancer |
DE122010000047I1 (de) | 2001-06-26 | 2011-05-05 | Amgen Fremont Inc | Antikörper gegen opgl |
CZ20022231A3 (cs) * | 2001-06-29 | 2003-02-12 | Sankyo Company Limited | Komplex skládající se z osteoklastogenezi inhibujícího faktoru a polysacharidu |
KR100427299B1 (ko) * | 2001-08-10 | 2004-04-14 | 한국생명공학연구원 | 인체 골 재흡수 억제인자(hOPG)를 생산하는 재조합플라스미드 pGHOPG(KCTC 1019BP) |
US20030049694A1 (en) * | 2001-09-10 | 2003-03-13 | Chung-Hsiun Wu | Production of fusion proteins and use for identifying binding molecules |
US6800462B2 (en) * | 2001-09-10 | 2004-10-05 | Abgenomics Corporation | Production of recombinant proteins in vivo and use for generating antibodies |
US7138370B2 (en) | 2001-10-11 | 2006-11-21 | Amgen Inc. | Specific binding agents of human angiopoietin-2 |
US7521053B2 (en) | 2001-10-11 | 2009-04-21 | Amgen Inc. | Angiopoietin-2 specific binding agents |
US7205275B2 (en) | 2001-10-11 | 2007-04-17 | Amgen Inc. | Methods of treatment using specific binding agents of human angiopoietin-2 |
JP4336467B2 (ja) * | 2001-10-15 | 2009-09-30 | 株式会社林原生物化学研究所 | 破骨細胞形成抑制因子の産生を調節し得る物質のスクリーニング方法 |
US20030191056A1 (en) | 2002-04-04 | 2003-10-09 | Kenneth Walker | Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins |
MXPA04009681A (es) * | 2002-04-05 | 2005-01-11 | Amgen Inc | Anticuerpos humanos neutralizantes anti-ligando de osteoprotegerina como inhibidores selectivos de la ruta del ligando de osteoprotegerina. |
US20080249068A1 (en) * | 2002-09-05 | 2008-10-09 | Deluca Hector F | Method of Extending the Dose Range of Vitamin D Compounds |
US7259143B2 (en) * | 2002-09-05 | 2007-08-21 | Wisconsin Alumni Research Foundation | Method of extending the dose range of vitamin D compounds |
JP2006521084A (ja) | 2002-12-10 | 2006-09-21 | シェーリング−プラウ・リミテッド | イヌranklならびにイヌranklを調製および使用するための方法 |
TWI293882B (en) | 2003-03-24 | 2008-03-01 | Sankyo Co | Polymeric modifiers and pharmaceutical compositions |
MX2007000216A (es) | 2004-07-08 | 2007-03-15 | Amgen Inc | Peptidos terapeuticos. |
NZ554390A (en) * | 2004-12-13 | 2010-07-30 | Cephalon Australia Vic Pty Ltd | Osteoprotegerin variant proteins |
US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
JO3324B1 (ar) | 2006-04-21 | 2019-03-13 | Amgen Inc | مركبات علاجية مجففة بالتبريد تتعلق بالعصارة الهضمية |
MX2009012609A (es) | 2007-05-22 | 2009-12-07 | Amgen Inc | Composiciones y metodos para producir proteinas de fusion bioactivas. |
NZ714757A (en) | 2009-08-14 | 2018-07-27 | Us Gov Health & Human Services | Use of il-15 to increase thymic output and to treat lymphopenia |
ES2630031T3 (es) | 2010-09-28 | 2017-08-17 | Aegerion Pharmaceuticals, Inc. | Un polipéptido de leptina pinnípedo-humano quimérico con solubilidad aumentada |
ES2942483T3 (es) | 2011-10-05 | 2023-06-01 | Oned Mat Inc | Materiales activos de nanoestructuras de silicio para baterías de iones de litio y procesos, composiciones, componentes y dispositivos relacionados con los mismos |
BR112014024398B1 (pt) * | 2012-03-31 | 2022-03-08 | R-Pharm International, Llc | Polipeptídeo que se liga ao rankl humano, composições terapêuticas compreendendo o dito polipeptídeo, ácido nucleico isolado, vetor de expressão e uso terapêutico do dito polipeptídeo |
EP3574017A1 (en) | 2017-01-27 | 2019-12-04 | Kymab Limited | Anti-opg antibodies |
JP6550413B2 (ja) * | 2017-02-24 | 2019-07-24 | アール−ファーム・インターナショナル・リミテッド・ライアビリティ・カンパニーR−Pharm International, Llc | オステオプロテゲリン由来の組成物およびその使用 |
CN111004318B (zh) * | 2019-12-30 | 2022-03-04 | 北京博康健基因科技有限公司 | rhPTH(1-34)蛋白原液的纯化方法 |
TW202203964A (zh) * | 2020-04-17 | 2022-02-01 | 小利蘭史丹佛大學董事會 | 用於生物醫藥調配物之聚合物賦形劑 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
US6936694B1 (en) | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
US4710473A (en) | 1983-08-10 | 1987-12-01 | Amgen, Inc. | DNA plasmids |
FR2640537B1 (fr) | 1988-12-21 | 1992-02-21 | Levy Guy | Installation et procede utilisant l'effet laser, pour la coupe ou la vaporisation de materiaux et tissus divers |
EP0401384B1 (en) | 1988-12-22 | 1996-03-13 | Kirin-Amgen, Inc. | Chemically modified granulocyte colony stimulating factor |
AU648505B2 (en) | 1989-05-19 | 1994-04-28 | Amgen, Inc. | Metalloproteinase inhibitor |
US5395760A (en) * | 1989-09-05 | 1995-03-07 | Immunex Corporation | DNA encoding tumor necrosis factor-α and -β receptors |
US5118667A (en) * | 1991-05-03 | 1992-06-02 | Celtrix Pharmaceuticals, Inc. | Bone growth factors and inhibitors of bone resorption for promoting bone formation |
CA2068389A1 (en) * | 1991-05-13 | 1992-11-14 | Masahiko Sato | Method for inhibiting bone resorption |
US5447851B1 (en) | 1992-04-02 | 1999-07-06 | Univ Texas System Board Of | Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells |
JP3284481B2 (ja) | 1993-08-20 | 2002-05-20 | 本田技研工業株式会社 | 車両用油圧作動式変速機の油圧制御回路 |
US6268212B1 (en) | 1993-10-18 | 2001-07-31 | Amgen Inc. | Tissue specific transgene expression |
JP3433495B2 (ja) | 1993-12-30 | 2003-08-04 | カシオ計算機株式会社 | 表示制御装置および表示制御方法 |
US6309853B1 (en) * | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
IL117175A (en) | 1995-02-20 | 2005-11-20 | Sankyo Co | Osteoclastogenesis inhibitory factor protein |
WO1996028546A1 (en) | 1995-03-15 | 1996-09-19 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptor |
US8615703B2 (en) | 2010-06-04 | 2013-12-24 | Micron Technology, Inc. | Advanced bitwise operations and apparatus in a multi-level system with nonvolatile memory |
-
1996
- 1996-09-03 US US08/706,945 patent/US6369027B1/en not_active Expired - Fee Related
- 1996-12-19 AR ARP960105797A patent/AR004400A1/es unknown
- 1996-12-20 KR KR1019970705843A patent/KR100463584B1/ko not_active IP Right Cessation
- 1996-12-20 CA CA2210467A patent/CA2210467C/en not_active Expired - Fee Related
- 1996-12-20 HU HU9801122A patent/HU227482B1/hu not_active IP Right Cessation
- 1996-12-20 FR FR9615707A patent/FR2742767B1/fr not_active Expired - Fee Related
- 1996-12-20 CN CNB961934417A patent/CN1318588C/zh not_active Expired - Fee Related
- 1996-12-20 NZ NZ332915A patent/NZ332915A/xx unknown
- 1996-12-20 CZ CZ19972538A patent/CZ292587B6/cs not_active IP Right Cessation
- 1996-12-20 YU YU69196A patent/YU69196A/sr unknown
- 1996-12-20 RO RO97-01539A patent/RO121386B1/ro unknown
- 1996-12-20 GB GB9626618A patent/GB2312899B/en not_active Expired - Fee Related
- 1996-12-20 NZ NZ326579A patent/NZ326579A/xx unknown
- 1996-12-20 EE EE9700164A patent/EE04643B1/xx not_active IP Right Cessation
- 1996-12-20 MX MX9706193A patent/MX9706193A/es not_active IP Right Cessation
- 1996-12-20 EP EP96945279A patent/EP0870023A1/en not_active Withdrawn
- 1996-12-20 PT PT96309363T patent/PT784093E/pt unknown
- 1996-12-20 EP EP10181616A patent/EP2332974A3/en not_active Withdrawn
- 1996-12-20 AU AU14686/97A patent/AU710587B2/en not_active Ceased
- 1996-12-20 JP JP52386197A patent/JP4657388B2/ja not_active Expired - Fee Related
- 1996-12-20 EP EP96309363A patent/EP0784093B1/en not_active Expired - Lifetime
- 1996-12-20 TR TR96/01036A patent/TR199601036A2/tr unknown
- 1996-12-20 DK DK96309363T patent/DK0784093T3/da active
- 1996-12-20 SK SK1107-97A patent/SK110797A3/sk not_active Application Discontinuation
- 1996-12-20 PL PL96321938A patent/PL187408B1/pl not_active IP Right Cessation
- 1996-12-20 AT AT96309363T patent/ATE409745T1/de active
- 1996-12-20 ES ES96309363T patent/ES2316152T3/es not_active Expired - Lifetime
- 1996-12-20 EP EP08003204A patent/EP1990415A1/en not_active Withdrawn
- 1996-12-20 SI SI9630764T patent/SI0784093T1/sl unknown
- 1996-12-20 WO PCT/US1996/020621 patent/WO1997023614A1/en active Application Filing
- 1996-12-20 DE DE19654610A patent/DE19654610A1/de not_active Ceased
-
1997
- 1997-08-05 BG BG101813A patent/BG63347B1/bg unknown
- 1997-08-11 IL IL121520A patent/IL121520A/en not_active IP Right Cessation
- 1997-08-12 NO NO973699A patent/NO973699L/no not_active Application Discontinuation
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1998
- 1998-01-16 HK HK98100367A patent/HK1001526A1/xx not_active IP Right Cessation
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