HK1001526A1 - Osteoprotegerin - Google Patents

Osteoprotegerin

Info

Publication number
HK1001526A1
HK1001526A1 HK98100367A HK98100367A HK1001526A1 HK 1001526 A1 HK1001526 A1 HK 1001526A1 HK 98100367 A HK98100367 A HK 98100367A HK 98100367 A HK98100367 A HK 98100367A HK 1001526 A1 HK1001526 A1 HK 1001526A1
Authority
HK
Hong Kong
Prior art keywords
osteoprotegerin
Prior art date
Application number
HK98100367A
Other languages
English (en)
Inventor
William J Boyle
Frank J Calzone
David L Lacey
Chang Ming-Shi
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/577,788 external-priority patent/US6613544B1/en
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of HK1001526A1 publication Critical patent/HK1001526A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
HK98100367A 1995-12-22 1998-01-16 Osteoprotegerin HK1001526A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/577,788 US6613544B1 (en) 1995-12-22 1995-12-22 Osteoprotegerin
US08/706,945 US6369027B1 (en) 1995-12-22 1996-09-03 Osteoprotegerin

Publications (1)

Publication Number Publication Date
HK1001526A1 true HK1001526A1 (en) 1998-06-26

Family

ID=27077338

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98100367A HK1001526A1 (en) 1995-12-22 1998-01-16 Osteoprotegerin

Country Status (31)

Country Link
US (1) US6369027B1 (tr)
EP (4) EP1990415A1 (tr)
JP (1) JP4657388B2 (tr)
KR (1) KR100463584B1 (tr)
CN (1) CN1318588C (tr)
AR (1) AR004400A1 (tr)
AT (1) ATE409745T1 (tr)
AU (1) AU710587B2 (tr)
BG (1) BG63347B1 (tr)
CA (1) CA2210467C (tr)
CZ (1) CZ292587B6 (tr)
DE (1) DE19654610A1 (tr)
DK (1) DK0784093T3 (tr)
EE (1) EE04643B1 (tr)
ES (1) ES2316152T3 (tr)
FR (1) FR2742767B1 (tr)
GB (1) GB2312899B (tr)
HK (1) HK1001526A1 (tr)
HU (1) HU227482B1 (tr)
IL (1) IL121520A (tr)
MX (1) MX9706193A (tr)
NO (1) NO973699L (tr)
NZ (2) NZ326579A (tr)
PL (1) PL187408B1 (tr)
PT (1) PT784093E (tr)
RO (1) RO121386B1 (tr)
SI (1) SI0784093T1 (tr)
SK (1) SK110797A3 (tr)
TR (1) TR199601036A2 (tr)
WO (1) WO1997023614A1 (tr)
YU (1) YU69196A (tr)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL117175A (en) 1995-02-20 2005-11-20 Sankyo Co Osteoclastogenesis inhibitory factor protein
US6919434B1 (en) 1995-02-20 2005-07-19 Sankyo Co., Ltd. Monoclonal antibodies that bind OCIF
US7078493B1 (en) 1995-03-15 2006-07-18 Human Genome Sciences, Inc. Antibodies to human tumor necrosis factor receptor-like genes
US7632922B1 (en) * 1995-12-22 2009-12-15 Amgen, Inc. Osteoprotegerin
US7005413B1 (en) 1995-12-22 2006-02-28 Amgen Inc. Combination therapy for conditions leading to bone loss
JPH1057071A (ja) * 1996-08-19 1998-03-03 Snow Brand Milk Prod Co Ltd 新規ｄｎａ及びそれを用いた蛋白質の製造方法
EP2002846B1 (en) 1996-12-06 2017-01-25 Amgen Inc. Combination therapy using an IL-1 inhibitor for treating IL-1 mediated diseases
US6271349B1 (en) 1996-12-23 2001-08-07 Immunex Corporation Receptor activator of NF-κB
DE69738841D1 (de) 1996-12-23 2008-08-28 Immunex Corp Ligand für rezeptor aktivator of nf-kappa b, ligand ist mitglied der tnf superfamilie
CN1138786C (zh) * 1997-04-15 2004-02-18 三共株式会社 识别破骨细胞形成抑制因子结合蛋白的抗体及制备和用途
US6316408B1 (en) 1997-04-16 2001-11-13 Amgen Inc. Methods of use for osetoprotegerin binding protein receptors
IL132304A0 (en) 1997-04-16 2001-03-19 Amgen Inc Osteoprotegerin binding proteins and receptors
EP0980432A1 (en) * 1997-05-01 2000-02-23 Amgen, Inc. Chimeric opg polypeptides
AU9013998A (en) * 1997-07-21 1999-02-10 Zymogenetics Inc. Tumor necrosis factor receptor ztnfr-5
WO1999007738A2 (en) * 1997-08-06 1999-02-18 Regeneron Pharmaceuticals, Inc. Human orphan receptor ntr-1
US6346388B1 (en) 1997-08-13 2002-02-12 Smithkline Beecham Corporation Method of identifying agonist and antagonists for tumor necrosis related receptors TR1 and TR2
WO1999011790A1 (en) * 1997-09-04 1999-03-11 Zymogenetics, Inc. Tumor necrosis factor receptor ztnfr-6
AU762959B2 (en) 1997-09-18 2003-07-10 Genentech Inc. DcR3 polypeptide, A TNFR homolog
RU2203497C2 (ru) * 1997-09-24 2003-04-27 Санкио Компани Лимитед Способ диагностики метаболических костных заболеваний
US6087555A (en) * 1997-10-15 2000-07-11 Amgen Inc. Mice lacking expression of osteoprotegerin
JPH11155420A (ja) * 1997-12-02 1999-06-15 Snow Brand Milk Prod Co Ltd トランスジェニック動物
CA2314884A1 (en) * 1997-12-16 1999-06-24 Incyte Pharmaceuticals, Inc. Human tumor necrosis factor-r2-like proteins
US6077689A (en) 1997-12-24 2000-06-20 Amgen Inc. Enhanced solubility of recombinant proteins
EP1054961A2 (en) * 1998-02-17 2000-11-29 Incyte Pharmaceuticals, Inc. Human short-chain tnf-receptor family protein
US6103472A (en) * 1998-02-20 2000-08-15 Amgen Inc. Methods and compositions for identifying novel secreted mammalian polypeptides in yeast
US6150098A (en) * 1998-02-20 2000-11-21 Amgen Inc. Methods for identifying novel secreted mammalian polypeptides
US6790823B1 (en) * 1998-04-23 2004-09-14 Amgen Inc. Compositions and methods for the prevention and treatment of cardiovascular diseases
JP4380067B2 (ja) * 1998-04-23 2009-12-09 味の素株式会社 抗血栓活性物質及びグリコカリシンの検出法
EP2009025B1 (en) 1998-05-14 2011-07-27 Immunex Corporation Method of inhibiting osteoclast activity
US6210924B1 (en) 1998-08-11 2001-04-03 Amgen Inc. Overexpressing cyclin D 1 in a eukaryotic cell line
IL141588A0 (en) 1998-09-15 2002-03-10 M & E Biotech As Method for down-regulating osteoprotegerin ligand activity
US6420339B1 (en) 1998-10-14 2002-07-16 Amgen Inc. Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
MEP42108A (en) 1998-10-23 2011-02-10 Kiren Amgen Inc Dimeric thrombopoietin peptide mimetics binding to mp1 receptor and having thrombopoietic activity
US7488590B2 (en) 1998-10-23 2009-02-10 Amgen Inc. Modified peptides as therapeutic agents
BR9914834A (pt) * 1998-10-28 2001-08-14 Snow Brand Milk Products Co Ltd Agente de tratamento de patobolismo ósseo, e, método para intensificar a atividade de fator inibidor de osteoclastogênese
US6245740B1 (en) 1998-12-23 2001-06-12 Amgen Inc. Polyol:oil suspensions for the sustained release of proteins
EP1144686A2 (en) * 1999-01-18 2001-10-17 Osteometer Biotech AS Genetic predisposition to abnormal calcification conditions
US20030007972A1 (en) * 1999-02-24 2003-01-09 Edward Tobinick Cytokine antagonists and other biologics for the treatment of bone metastases
US7259253B2 (en) * 1999-05-14 2007-08-21 Quark Biotech, Inc. Genes associated with mechanical stress, expression products therefrom, and uses thereof
WO2001003719A2 (en) * 1999-07-09 2001-01-18 Amgen Inc. Combination therapy for conditions leading to bone loss
AUPQ167599A0 (en) * 1999-07-19 1999-08-12 St. Vincent's Institute Of Medical Research Inhibitor of osteoclast precursor formation
IL130989A0 (en) * 1999-07-20 2001-01-28 Compugen Ltd Variants of alternative splicing
US6673771B1 (en) 1999-07-28 2004-01-06 The Trustees Of The University Of Pennsylvania Methods of inhibiting osteoclast activity
US8106098B2 (en) 1999-08-09 2012-01-31 The General Hospital Corporation Protein conjugates with a water-soluble biocompatible, biodegradable polymer
AU6946300A (en) * 1999-08-30 2001-03-26 Mayo Foundation For Medical Education And Research Use of dna encoding osteoprotegerin to prevent or inhibit metabolic bone disorders
KR20010085996A (ko) * 1999-09-03 2001-09-07 스티븐 엠. 오드레 암 및 암관련 골손실을 예방 또는 치료하는 조성물 및 방법
US20030144187A1 (en) * 1999-09-03 2003-07-31 Colin R. Dunstan Opg fusion protein compositions and methods
AU2005237128B2 (en) * 1999-09-03 2008-09-11 Amgen Inc. Compositions and Methods for the Prevention or Treatment of Cancer and Bone Loss Associated with Cancer
US6808902B1 (en) 1999-11-12 2004-10-26 Amgen Inc. Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules
AR026946A1 (es) * 1999-12-16 2003-03-05 Amgen Inc Osteoprotegerina/receptores de factores de necrosis de tumores
US20030103978A1 (en) 2000-02-23 2003-06-05 Amgen Inc. Selective binding agents of osteoprotegerin binding protein
PT2077279E (pt) 2000-06-28 2012-09-14 Amgen Inc Moléculas do receptor de linfopoietina estromal tímica e suas utilizações
MXPA03002443A (es) * 2000-09-22 2004-12-06 Immunex Corp Ensayos de clasificacion para agonistas o antagonistas del activador receptor de nf-kb.
EP1399555A2 (en) * 2001-02-09 2004-03-24 Maxygen Holdings Ltd. c/o Close Brothers (Cayman) Limited Rank ligand-binding polypeptides
EP1377610A2 (en) 2001-04-03 2004-01-07 Société des Produits Nestlé S.A. Osteoprotegerin in milk
WO2002098362A2 (en) * 2001-06-06 2002-12-12 Immunex Corporation Use of rank antagonists to treat cancer
CA2451955C (en) 2001-06-26 2015-09-29 Abgenix, Inc. Antibodies to opgl
EP1270015A3 (en) * 2001-06-29 2004-02-25 Sankyo Company Limited A complex comprising OCIF and Polysaccharide
KR100427299B1 (ko) * 2001-08-10 2004-04-14 한국생명공학연구원 인체 골 재흡수 억제인자（ｈＯＰＧ）를 생산하는 재조합플라스미드 ｐＧＨＯＰＧ（ＫＣＴＣ １０１９ＢＰ）
US20030049694A1 (en) * 2001-09-10 2003-03-13 Chung-Hsiun Wu Production of fusion proteins and use for identifying binding molecules
US6800462B2 (en) * 2001-09-10 2004-10-05 Abgenomics Corporation Production of recombinant proteins in vivo and use for generating antibodies
US7138370B2 (en) 2001-10-11 2006-11-21 Amgen Inc. Specific binding agents of human angiopoietin-2
US7205275B2 (en) 2001-10-11 2007-04-17 Amgen Inc. Methods of treatment using specific binding agents of human angiopoietin-2
US7521053B2 (en) 2001-10-11 2009-04-21 Amgen Inc. Angiopoietin-2 specific binding agents
JP4336467B2 (ja) * 2001-10-15 2009-09-30 株式会社林原生物化学研究所 破骨細胞形成抑制因子の産生を調節し得る物質のスクリーニング方法
US20030191056A1 (en) 2002-04-04 2003-10-09 Kenneth Walker Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins
CA2481074A1 (en) * 2002-04-05 2003-10-23 Amgen Inc. Human anti-opgl neutralizing antibodies as selective opgl pathway inhibitors
US20080249068A1 (en) * 2002-09-05 2008-10-09 Deluca Hector F Method of Extending the Dose Range of Vitamin D Compounds
US7259143B2 (en) * 2002-09-05 2007-08-21 Wisconsin Alumni Research Foundation Method of extending the dose range of vitamin D compounds
WO2004052233A2 (en) 2002-12-10 2004-06-24 Schering-Plough Ltd. Canine rankl and methods for preparing and using the same
TWI293882B (en) 2003-03-24 2008-03-01 Sankyo Co Polymeric modifiers and pharmaceutical compositions
EP1773400A2 (en) 2004-07-08 2007-04-18 Amgen Inc. Therapeutic peptides
KR101250364B1 (ko) 2004-12-13 2013-04-05 세파론 오스트레일리아 (브이아이씨) 피티와이 엘티디 오스테오프로테게린 변이체 단백질
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
US9283260B2 (en) 2006-04-21 2016-03-15 Amgen Inc. Lyophilized therapeutic peptibody formulations
AU2008262490B2 (en) 2007-05-22 2011-11-17 Amgen Inc. Compositions and methods for producing bioactive fusion proteins
CA2768965C (en) 2009-08-14 2019-06-04 George N. Pavlakis Use of il-15 to increase thymic output and to treat lymphopenia
WO2012050925A2 (en) 2010-09-28 2012-04-19 Amylin Pharmaceuticals, Inc. Highly soluble leptins
EP2764565B1 (en) 2011-10-05 2023-02-22 OneD Material, Inc. Silicon nanostructure active materials for lithium ion batteries and processes, compositions, components, and devices related thereto
SG11201406216XA (en) * 2012-03-31 2015-03-30 Pharm Cjsc Closed Joint Stock Company R Osteoprotegerin derived composition and use thereof
EP3574017A1 (en) 2017-01-27 2019-12-04 Kymab Limited Anti-opg antibodies
JP6550413B2 (ja) * 2017-02-24 2019-07-24 アール−ファーム・インターナショナル・リミテッド・ライアビリティ・カンパニーＲ−Ｐｈａｒｍ Ｉｎｔｅｒｎａｔｉｏｎａｌ， Ｌｌｃ オステオプロテゲリン由来の組成物およびその使用
CN111004318B (zh) * 2019-12-30 2022-03-04 北京博康健基因科技有限公司 rhPTH(1-34)蛋白原液的纯化方法
TW202203964A (zh) * 2020-04-17 2022-02-01 小利蘭史丹佛大學董事會 用於生物醫藥調配物之聚合物賦形劑

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US6936694B1 (en) 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
US4710473A (en) 1983-08-10 1987-12-01 Amgen, Inc. DNA plasmids
FR2640537B1 (fr) 1988-12-21 1992-02-21 Levy Guy Installation et procede utilisant l'effet laser, pour la coupe ou la vaporisation de materiaux et tissus divers
EP0401384B1 (en) 1988-12-22 1996-03-13 Kirin-Amgen, Inc. Chemically modified granulocyte colony stimulating factor
JP2877509B2 (ja) 1989-05-19 1999-03-31 アムジエン・インコーポレーテツド メタロプロテイナーゼ阻害剤
US5395760A (en) * 1989-09-05 1995-03-07 Immunex Corporation DNA encoding tumor necrosis factor-α and -β receptors
US5118667A (en) * 1991-05-03 1992-06-02 Celtrix Pharmaceuticals, Inc. Bone growth factors and inhibitors of bone resorption for promoting bone formation
CA2068389A1 (en) * 1991-05-13 1992-11-14 Masahiko Sato Method for inhibiting bone resorption
US5447851B1 (en) 1992-04-02 1999-07-06 Univ Texas System Board Of Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells
JP3284481B2 (ja) 1993-08-20 2002-05-20 本田技研工業株式会社 車両用油圧作動式変速機の油圧制御回路
US6268212B1 (en) 1993-10-18 2001-07-31 Amgen Inc. Tissue specific transgene expression
JP3433495B2 (ja) 1993-12-30 2003-08-04 カシオ計算機株式会社 表示制御装置および表示制御方法
US6309853B1 (en) * 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
IL117175A (en) 1995-02-20 2005-11-20 Sankyo Co Osteoclastogenesis inhibitory factor protein
WO1996028546A1 (en) 1995-03-15 1996-09-19 Human Genome Sciences, Inc. Human tumor necrosis factor receptor
US8615703B2 (en) 2010-06-04 2013-12-24 Micron Technology, Inc. Advanced bitwise operations and apparatus in a multi-level system with nonvolatile memory

Also Published As

Publication number Publication date
CZ253897A3 (cs) 1999-03-17
JP4657388B2 (ja) 2011-03-23
GB2312899A (en) 1997-11-12
AU1468697A (en) 1997-07-17
WO1997023614A1 (en) 1997-07-03
DE19654610A1 (de) 1997-06-26
CN1318588C (zh) 2007-05-30
GB2312899B (en) 1999-05-05
GB9626618D0 (en) 1997-02-05
EE9700164A (et) 1998-02-16
HU227482B1 (en) 2011-07-28
EP0870023A1 (en) 1998-10-14
FR2742767A1 (fr) 1997-06-27
EP2332974A2 (en) 2011-06-15
KR19980703599A (ko) 1998-12-05
ATE409745T1 (de) 2008-10-15
BG101813A (en) 1998-09-30
IL121520A (en) 2010-11-30
HUP9801122A3 (en) 2000-09-28
BG63347B1 (bg) 2001-10-31
EP0784093B1 (en) 2008-10-01
TR199601036A3 (tr) 1997-07-21
PT784093E (pt) 2008-12-17
NZ326579A (en) 1999-01-28
AR004400A1 (es) 1998-11-04
KR100463584B1 (ko) 2005-06-07
SI0784093T1 (sl) 2009-04-30
DK0784093T3 (da) 2008-12-15
CA2210467A1 (en) 1997-07-03
YU69196A (en) 1999-11-22
PL321938A1 (en) 1998-01-05
AU710587B2 (en) 1999-09-23
EP2332974A3 (en) 2012-01-11
CA2210467C (en) 2011-02-08
MX9706193A (es) 1997-11-29
RO121386B1 (ro) 2007-04-30
CZ292587B6 (cs) 2003-10-15
CN1182452A (zh) 1998-05-20
EP1990415A1 (en) 2008-11-12
ES2316152T3 (es) 2009-04-01
SK110797A3 (en) 1999-07-12
PL187408B1 (pl) 2004-07-30
FR2742767B1 (fr) 2001-03-30
NO973699D0 (no) 1997-08-12
US6369027B1 (en) 2002-04-09
EE04643B1 (et) 2006-06-15
NO973699L (no) 1997-10-21
NZ332915A (en) 2000-07-28
JPH11503616A (ja) 1999-03-30
EP0784093A1 (en) 1997-07-16
HUP9801122A2 (hu) 1998-08-28
TR199601036A2 (tr) 1997-07-21

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