TN2010000122A1 - Compounds and compositions as modulators of gpr119 activity - Google Patents
Compounds and compositions as modulators of gpr119 activityInfo
- Publication number
- TN2010000122A1 TN2010000122A1 TNP2010000122A TN2010000122A TN2010000122A1 TN 2010000122 A1 TN2010000122 A1 TN 2010000122A1 TN P2010000122 A TNP2010000122 A TN P2010000122A TN 2010000122 A TN2010000122 A TN 2010000122A TN 2010000122 A1 TN2010000122 A1 TN 2010000122A1
- Authority
- TN
- Tunisia
- Prior art keywords
- compounds
- compositions
- modulators
- gpr119 activity
- gpr119
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Reproductive Health (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Gynecology & Obstetrics (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Pregnancy & Childbirth (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US97406407P | 2007-09-20 | 2007-09-20 | |
US4526308P | 2008-04-15 | 2008-04-15 | |
PCT/US2008/075145 WO2009038974A1 (fr) | 2007-09-20 | 2008-09-03 | Composés et compositions en tant que modulateurs de l'activité de gpr119 |
Publications (1)
Publication Number | Publication Date |
---|---|
TN2010000122A1 true TN2010000122A1 (en) | 2011-09-26 |
Family
ID=40039643
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TNP2010000122A TN2010000122A1 (en) | 2007-09-20 | 2010-03-19 | Compounds and compositions as modulators of gpr119 activity |
Country Status (22)
Country | Link |
---|---|
US (3) | US8153635B2 (fr) |
EP (1) | EP2197873B1 (fr) |
JP (1) | JP5465177B2 (fr) |
KR (1) | KR20100055536A (fr) |
CN (1) | CN101801954B (fr) |
AR (1) | AR068496A1 (fr) |
AU (1) | AU2008302570B2 (fr) |
BR (1) | BRPI0817211A2 (fr) |
CA (1) | CA2697551C (fr) |
CL (1) | CL2008002787A1 (fr) |
CO (1) | CO6270362A2 (fr) |
CR (1) | CR11292A (fr) |
EC (1) | ECSP10010042A (fr) |
ES (1) | ES2499018T3 (fr) |
MA (1) | MA31764B1 (fr) |
MX (1) | MX2010003117A (fr) |
NZ (1) | NZ583495A (fr) |
PE (1) | PE20090708A1 (fr) |
RU (1) | RU2443699C2 (fr) |
TN (1) | TN2010000122A1 (fr) |
TW (1) | TWI368618B (fr) |
WO (1) | WO2009038974A1 (fr) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2295816T3 (es) | 2003-01-14 | 2008-04-16 | Arena Pharmaceuticals, Inc. | Derivados arilo y heteroarilo 1,2,3-trisustituidos como moduladores del metabolismo, y profilaxis y tratamiento de transtornos relacionados con los mismos, tales como la diabetes y la hiperglucemia. |
AU2008302570B2 (en) | 2007-09-20 | 2012-05-31 | Irm Llc | Compounds and compositions as modulators of GPR119 activity |
EP2271619A1 (fr) * | 2008-04-07 | 2011-01-12 | Irm Llc | Composés et compositions servant de modulateurs de l activité de gpr119 |
EP2108960A1 (fr) | 2008-04-07 | 2009-10-14 | Arena Pharmaceuticals, Inc. | Procédés d'utilisation d'un récepteur couplé à protéine G pour identifier les secrétagogues de peptide YY (PYY) et composés utiles dans le traitement des conditions modulées de secrétagogues BY (PYY) et composés utiles dans le traitement des conditions par PYY |
BRPI0915867A2 (pt) * | 2008-07-11 | 2017-06-20 | Irm Llc | 4-fenoximetilpiperidinas como moduladores de atividade de gpr119 |
JP5538528B2 (ja) | 2009-06-18 | 2014-07-02 | カディラ・ヘルスケア・リミテッド | 新規なgpr119アゴニスト |
TW201113269A (en) | 2009-06-24 | 2011-04-16 | Boehringer Ingelheim Int | New compounds, pharmaceutical composition and methods relating thereto |
EA201200046A1 (ru) | 2009-06-24 | 2012-08-30 | Бёрингер Ингельхайм Интернациональ Гмбх | Новые соединения, фармацевтическая композиция и связанные с ними способы |
AR077638A1 (es) * | 2009-07-15 | 2011-09-14 | Lilly Co Eli | Compuesto de (metanosulfonil -piperidin )-( alcoxi-aril) -tetrahidro- piridina , composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para el tratamiento de diabetes u obesidad |
US8552022B2 (en) | 2009-08-13 | 2013-10-08 | Merck Sharp & Dohme Corp. | Substituted cyclopropyl compounds, compositions containing such compounds and methods of treatment |
WO2011030139A1 (fr) | 2009-09-11 | 2011-03-17 | Astrazeneca Ab | Derives de 4-(pyrimidin-2-yl)-piperazine et de 4-(pyrimidin-2-yl)-piperidine utilises en tant que modulateurs du gpr119 |
JP2013507366A (ja) * | 2009-10-09 | 2013-03-04 | アイアールエム・リミテッド・ライアビリティ・カンパニー | Gpr119活性モジュレーターとしての化合物および組成物 |
US8912206B2 (en) | 2009-11-23 | 2014-12-16 | Merck Sharp & Dohme Corp. | Pyrimidine ether derivatives and methods of use thereof |
CA2786994C (fr) | 2010-01-27 | 2018-01-16 | Arena Pharmaceuticals, Inc. | Procedes de preparation d'acide (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta]indol-3-yl) acetique et de ses sels |
WO2011100401A1 (fr) * | 2010-02-11 | 2011-08-18 | Bristol-Myers Squibb Company | Macrocycles utilisés en tant qu'inhibiteurs du facteur xia |
WO2011107494A1 (fr) | 2010-03-03 | 2011-09-09 | Sanofi | Nouveaux dérivés aromatiques de glycoside, médicaments contenants ces composés, et leur utilisation |
US20130109703A1 (en) | 2010-03-18 | 2013-05-02 | Boehringer Ingelheim International Gmbh | Combination of a GPR119 Agonist and the DPP-IV Inhibitor Linagliptin for Use in the Treatment of Diabetes and Related Conditions |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
WO2012040279A1 (fr) | 2010-09-22 | 2012-03-29 | Arena Pharmaceuticals, Inc. | Modulateurs du récepteur gpr119 et traitement des troubles qui lui sont liés |
UY33805A (es) * | 2010-12-17 | 2012-07-31 | Boehringer Ingelheim Int | ?Derivados de dihidrobenzofuranil-piperidinilo, aza-dihidrobenzofuranilpiperidinilo y diaza-dihidrobenzofuranil-piperidinilo, composiciones farmacéuticas que los contienen y usos de los mismos?. |
US20140018371A1 (en) * | 2011-04-01 | 2014-01-16 | Arena Pharmaceuticals, Inc. | Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto |
AU2012240122B2 (en) * | 2011-04-08 | 2016-08-25 | Merck Sharp & Dohme Corp. | Substituted cyclopropyl compounds, compositions containing such compounds and methods of treatment |
US20140066369A1 (en) * | 2011-04-19 | 2014-03-06 | Arena Pharmaceuticals, Inc. | Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto |
US9006228B2 (en) | 2011-06-16 | 2015-04-14 | Merck Sharp & Dohme Corp. | Substituted cyclopropyl compounds, compositions containing such compounds, and methods of treatment |
WO2013037390A1 (fr) | 2011-09-12 | 2013-03-21 | Sanofi | Dérivés amides d'acide 6-(4-hydroxyphényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase |
EP2760862B1 (fr) | 2011-09-27 | 2015-10-21 | Sanofi | Dérivés d'amide d'acide 6-(4-hydroxyphényl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique utilisés comme inhibiteurs de kinase |
EP2760855B1 (fr) * | 2011-09-30 | 2017-03-15 | Merck Sharp & Dohme Corp. | Composés de cyclopropyle substitués, compositions contenant ces composés ainsi que leur utilisation pour le traitement du diabète de type 2 |
EP2771000B1 (fr) | 2011-10-24 | 2016-05-04 | Merck Sharp & Dohme Corp. | Composés de pipéridinyle substitués utilisés comme agonistes du récepteur gpr119 |
EP2780337B1 (fr) | 2011-11-15 | 2017-12-20 | Merck Sharp & Dohme Corp. | Composés de cyclopropyle substitués utiles à titre d'agonistes de gpr119 |
WO2013122821A1 (fr) * | 2012-02-14 | 2013-08-22 | Merck Sharp & Dohme Corp. | Composés cyclopropylés substitués utiles comme agonistes de gpr119 |
ES2759010T3 (es) * | 2012-06-12 | 2020-05-07 | Chong Kun Dang Pharmaceutical Corp | Derivados de piperidina como agonistas del GPR119 |
AU2013290100A1 (en) | 2012-07-11 | 2015-01-29 | Elcelyx Therapeutics, Inc. | Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk |
WO2014052619A1 (fr) * | 2012-09-27 | 2014-04-03 | Irm Llc | Dérivés et compositions de pipéridine comme modulateurs de l'activité de gpr119 |
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2008
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- 2008-09-03 WO PCT/US2008/075145 patent/WO2009038974A1/fr active Application Filing
- 2008-09-03 CA CA2697551A patent/CA2697551C/fr not_active Expired - Fee Related
- 2008-09-03 JP JP2010525885A patent/JP5465177B2/ja not_active Expired - Fee Related
- 2008-09-03 EP EP08831608.8A patent/EP2197873B1/fr active Active
- 2008-09-03 KR KR1020107008477A patent/KR20100055536A/ko not_active Application Discontinuation
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2011
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- 2012-03-16 US US13/423,041 patent/US20120196844A1/en not_active Abandoned
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CR11292A (es) | 2010-03-22 |
AU2008302570A1 (en) | 2009-03-26 |
WO2009038974A1 (fr) | 2009-03-26 |
RU2010115260A (ru) | 2011-10-27 |
CN101801954B (zh) | 2013-10-09 |
ECSP10010042A (es) | 2010-04-30 |
MA31764B1 (fr) | 2010-10-01 |
US8153635B2 (en) | 2012-04-10 |
CL2008002787A1 (es) | 2009-05-15 |
US20090270409A1 (en) | 2009-10-29 |
ES2499018T3 (es) | 2014-09-26 |
JP2010540441A (ja) | 2010-12-24 |
NZ583495A (en) | 2011-11-25 |
KR20100055536A (ko) | 2010-05-26 |
JP5465177B2 (ja) | 2014-04-09 |
EP2197873A1 (fr) | 2010-06-23 |
US20110224185A1 (en) | 2011-09-15 |
US20120196844A1 (en) | 2012-08-02 |
MX2010003117A (es) | 2010-04-01 |
CO6270362A2 (es) | 2011-04-20 |
TWI368618B (en) | 2012-07-21 |
AU2008302570B2 (en) | 2012-05-31 |
CA2697551C (fr) | 2013-03-12 |
US8258156B2 (en) | 2012-09-04 |
EP2197873B1 (fr) | 2014-07-16 |
PE20090708A1 (es) | 2009-07-15 |
TW200914448A (en) | 2009-04-01 |
CN101801954A (zh) | 2010-08-11 |
CA2697551A1 (fr) | 2009-03-26 |
RU2443699C2 (ru) | 2012-02-27 |
BRPI0817211A2 (pt) | 2017-05-16 |
AR068496A1 (es) | 2009-11-18 |
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