WO2011014520A3 - Composés et compositions pouvant servir de modulateurs de l'activité du gpr119 - Google Patents

Composés et compositions pouvant servir de modulateurs de l'activité du gpr119 Download PDF

Info

Publication number
WO2011014520A3
WO2011014520A3 PCT/US2010/043433 US2010043433W WO2011014520A3 WO 2011014520 A3 WO2011014520 A3 WO 2011014520A3 US 2010043433 W US2010043433 W US 2010043433W WO 2011014520 A3 WO2011014520 A3 WO 2011014520A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
compositions
modulators
gpr119 activity
gpr119
Prior art date
Application number
PCT/US2010/043433
Other languages
English (en)
Other versions
WO2011014520A2 (fr
Inventor
Phillip Alper
Mihai Azimioara
Christopher Cow
Robert Epple
Gerald Lelais
Daniel Mutnick
Victor Nikulin
Original Assignee
Irm Llc
Mecom, John
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Irm Llc, Mecom, John filed Critical Irm Llc
Publication of WO2011014520A2 publication Critical patent/WO2011014520A2/fr
Publication of WO2011014520A3 publication Critical patent/WO2011014520A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des composés, des compositions pharmaceutiques contenant de tels composés et des méthodes d'utilisation de tels composés pour traiter ou prévenir des maladies ou des troubles associés à l'activité du GPR119.
PCT/US2010/043433 2009-07-29 2010-07-27 Composés et compositions pouvant servir de modulateurs de l'activité du gpr119 WO2011014520A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22943409P 2009-07-29 2009-07-29
US61/229,434 2009-07-29

Publications (2)

Publication Number Publication Date
WO2011014520A2 WO2011014520A2 (fr) 2011-02-03
WO2011014520A3 true WO2011014520A3 (fr) 2011-06-23

Family

ID=42732133

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/043433 WO2011014520A2 (fr) 2009-07-29 2010-07-27 Composés et compositions pouvant servir de modulateurs de l'activité du gpr119

Country Status (1)

Country Link
WO (1) WO2011014520A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2718279B1 (fr) 2011-06-09 2016-08-10 Rhizen Pharmaceuticals SA Composés nouveaux comme modulateurs de la gpr119
US9447099B2 (en) * 2011-10-04 2016-09-20 Hoffmann-La Roche Inc. Methods for the preparation of 5-[2-[7 (trifluoromethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo [1,5-A]pyrimidin-3-yl[ethynyl]-2-pyridinamine
EP2872127A1 (fr) 2012-07-11 2015-05-20 Elcelyx Therapeutics, Inc. Compositions comportant des statines, des biguanides et d'autres agents pour réduire un risque cardiométabolique
AU2013348018A1 (en) * 2012-11-20 2015-06-04 Discoverybiomed, Inc. Small molecule CFTR correctors
EP2922853A4 (fr) 2012-11-20 2016-11-23 Discoverybiomed Inc Correcteurs de cftr bicycliques et tricycliques à petites molécules
CN114315899B (zh) * 2020-09-30 2024-09-03 上海美迪西生物医药股份有限公司 3-（芳环并咪唑基）吡唑并嘧啶类衍生物及其应用

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5612114B2 (fr) 1974-06-07 1981-03-18
US4231938A (en) 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
MX7065E (es) 1980-06-06 1987-04-10 Sankyo Co Un procedimiento microbiologico para preparar derivados de ml-236b
US4450171A (en) 1980-08-05 1984-05-22 Merck & Co., Inc. Antihypercholesterolemic compounds
US4448784A (en) 1982-04-12 1984-05-15 Hoechst-Roussel Pharmaceuticals, Inc. 1-(Aminoalkylphenyl and aminoalkylbenzyl)-indoles and indolines and analgesic method of use thereof
US4499289A (en) 1982-12-03 1985-02-12 G. D. Searle & Co. Octahydronapthalenes
CA1327360C (fr) 1983-11-14 1994-03-01 William F. Hoffman Analogues oxo d'agents antihypercholesterolemiants ayant les caracteristiques de la mevinoline
US4613610A (en) 1984-06-22 1986-09-23 Sandoz Pharmaceuticals Corp. Cholesterol biosynthesis inhibiting pyrazole analogs of mevalonolactone and its derivatives
US4686237A (en) 1984-07-24 1987-08-11 Sandoz Pharmaceuticals Corp. Erythro-(E)-7-[3'-C1-3 alkyl-1'-(3",5"-dimethylphenyl)naphth-2'-yl]-3,5-dihydroxyhept-6-enoic acids and derivatives thereof
US4647576A (en) 1984-09-24 1987-03-03 Warner-Lambert Company Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis
KR910003427B1 (ko) 1984-12-04 1991-05-31 산도즈 파마슈티칼스 코포레이션 메발로노락톤의 인덴동족체 및 이들의 유도체의 제법
US4668794A (en) 1985-05-22 1987-05-26 Sandoz Pharm. Corp. Intermediate imidazole acrolein analogs
KR900001212B1 (ko) 1985-10-25 1990-02-28 산도즈 파마슈티칼스 코오포레이숀 메바로노락톤 및 그것의 유도체의 헤테로사이클릭 유사체 및 그것의 생산방법 및 약학적인 그것의 용도
FR2596393B1 (fr) 1986-04-01 1988-06-03 Sanofi Sa Derives de l'acide hydroxy-3 dihydroxyoxophosphorio-4 butanoique, leur procede de preparation, leur application comme medicament et les compositions les renfermant
AU610591B2 (en) 1987-05-22 1991-05-23 E.R. Squibb & Sons, Inc. Phosphorus-containing hmg-coa reductase inhibitors, new intermediates and method
US5506219A (en) 1988-08-29 1996-04-09 E. R. Squibb & Sons, Inc. Pyridine anchors for HMG-CoA reductase inhibitors
US5753675A (en) 1989-03-03 1998-05-19 Novartis Pharmaceuticals Corporation Quinoline analogs of mevalonolactone and derivatives thereof
HUT64023A (en) 1991-03-22 1993-11-29 Sandoz Ag Process for producing aminoguanidine derivatives and pharmaceutical compositions comprising such compounds
TW225528B (fr) 1992-04-03 1994-06-21 Ciba Geigy Ag
US5776983A (en) 1993-12-21 1998-07-07 Bristol-Myers Squibb Company Catecholamine surrogates useful as β3 agonists
US5488064A (en) 1994-05-02 1996-01-30 Bristol-Myers Squibb Company Benzo 1,3 dioxole derivatives
US5491134A (en) 1994-09-16 1996-02-13 Bristol-Myers Squibb Company Sulfonic, phosphonic or phosphiniic acid β3 agonist derivatives
US5541204A (en) 1994-12-02 1996-07-30 Bristol-Myers Squibb Company Aryloxypropanolamine β 3 adrenergic agonists
US6236946B1 (en) 1995-12-13 2001-05-22 Thomas S. Scanlan Nuclear receptor ligands and ligand binding domains
US5770615A (en) 1996-04-04 1998-06-23 Bristol-Myers Squibb Company Catecholamine surrogates useful as β3 agonists
GB9713739D0 (en) 1997-06-27 1997-09-03 Karobio Ab Thyroid receptor ligands
IL140622A0 (en) 1998-07-06 2002-02-10 Bristol Myers Squibb Co Biphenyl sufonamide derivatives, pharmaceutical compositions containing the same and methods for the preparation thereof
CO5150173A1 (es) 1998-12-10 2002-04-29 Novartis Ag Compuestos n-(glicilo sustituido)-2-cianopirrolidinas inhibidores de peptidasa de dipeptidilo-iv (dpp-iv) los cuales son efectivos en el tratamiento de condiciones mediadas por la inhibicion de dpp-iv
TW200303742A (en) 2001-11-21 2003-09-16 Novartis Ag Organic compounds
GB0215676D0 (en) 2002-07-05 2002-08-14 Novartis Ag Organic compounds
MXPA05005425A (es) 2002-11-22 2005-11-23 Japan Tobacco Inc Heterociclos que contienen nitrogeno, biciclicos, fusionados.
US20040185559A1 (en) 2003-03-21 2004-09-23 Isis Pharmaceuticals Inc. Modulation of diacylglycerol acyltransferase 1 expression
ES2568769T3 (es) 2003-07-30 2016-05-04 Xenon Pharmaceuticals Inc. Derivados de piperazina y su uso como agentes terapéuticos
EP1653969A4 (fr) 2003-08-07 2006-12-20 Japan Tobacco Inc Derives de pyrrolo 1,2-b pyridazine
GB0325192D0 (en) 2003-10-29 2003-12-03 Astrazeneca Ab Method of use
AR051596A1 (es) 2004-10-26 2007-01-24 Irm Llc Compuestos heterociclicos condensados nitrogenados como inhibidores de la actividad del receptor canabinoide 1; composiciones farmaceuticas que los contienen y su empleo en la preparacion de medicamentos para el tratamiento de trastornos alimentarios

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHUVASHLEV, A. S.; KRYL'SKII, D. V.: "5-Amino-3-alkyl-2-arylpyrazoles in synthesis of pyrazolo[1,5-a]pyrimidines", IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENII, KHIMIYA I KHIMICHESKAYA TEKHNOLOGIYA, 2009, pages 50 - 30, XP008134465 *
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ., XP002631289, Database accession no. 1030473-31-4 *
JONES ROBERT M ET AL: "GPR119 agonists for the treatment of type 2 diabetes.", EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 19, no. 10, October 2009 (2009-10-01), pages 1339 - 1359, XP002631290, ISSN: 1744-7674 *
POTTS ET ALL: "Bridgehead Nitrogen Heterocycles I. A Convenient Synthesis of Pyrazolo[1,5-a]pyridines", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 33, no. 10, 1 October 1968 (1968-10-01), pages 3766 - 3770, XP002631287 *
THOMAS A ET AL: "Cyclocondensation of oxoketene dithioacetals with 3-aminopyrazoles: A facile highly regioselective general route to substituted and fused pyrazolo[a]pyrimidines", vol. 46, 1990, TETRAHEDRON, GB, ISSN: 0040-4020, pages: 577 - 586, XP002631288 *

Also Published As

Publication number Publication date
WO2011014520A2 (fr) 2011-02-03

Similar Documents

Publication Publication Date Title
TN2010000122A1 (en) Compounds and compositions as modulators of gpr119 activity
MX2009009491A (es) Compuestos y composiciones como moduladores de la actividad del gpr119.
PH12020550450A1 (en) Certain chemical entities, compositions and methods
MX2012004078A (es) Compuestos y composiciones como moduladores de la actividad de gpr119.
EA200901032A1 (ru) Соединения и композиции в качестве модуляторов активности gpr119
EA201001329A1 (ru) Соединения и композиции в качестве модуляторов активности gpr119
IN2012DN02469A (fr)
MX2009007944A (es) Compuestos y composiciones de purina como inhibidores de quinasa para el tratamiento de enfermedades relacionadas con plasmodium.
PH12015501806B1 (en) Novel benzopyran kinase modulators
WO2008124849A3 (fr) Modulateurs de pyrrolo-pyridine kinase
EA201001332A1 (ru) Соединения и композиции в качестве модуляторов активности gpr119
WO2012024620A3 (fr) Inhibiteurs de l'autotaxine et leurs utilisations
EA201100138A1 (ru) 4-феноксиметилпиперидины в качестве модуляторов активности gpr119
WO2009129246A3 (fr) Compositions et leurs procédés de préparation et d'utilisation
WO2009089494A3 (fr) Compositions pharmaceutiques
WO2011017108A3 (fr) Modulateurs cyclopropylés du récepteur p2y12
WO2011014795A3 (fr) Composés et compositions pouvant servir d'inhibiteurs de la kinase syk
WO2011140202A3 (fr) Modulateurs de mif
WO2012064973A3 (fr) Composés hétérocycliques et utilisations de ceux-ci
EA201001330A1 (ru) Соединения и композиции в качестве модуляторов активности gpr119
WO2010127152A3 (fr) Composés et compositions comme inhibiteurs de la prostaglandine e synthase-1 microsomale
UA103930C2 (ru) Соединения и композиция для лечения паразитарных болезней
WO2011088160A3 (fr) Nouveaux inhibiteurs de cyp17
WO2011014520A3 (fr) Composés et compositions pouvant servir de modulateurs de l'activité du gpr119
WO2012082942A3 (fr) Analogues de neuropeptides, compositions et procédés pour le traitement de la douleur

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 10738135

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 10738135

Country of ref document: EP

Kind code of ref document: A2