JP2002112793A - 新規ｇ蛋白質共役受容体 - Google Patents
新規ｇ蛋白質共役受容体Info
- Publication number
- JP2002112793A JP2002112793A JP2001034434A JP2001034434A JP2002112793A JP 2002112793 A JP2002112793 A JP 2002112793A JP 2001034434 A JP2001034434 A JP 2001034434A JP 2001034434 A JP2001034434 A JP 2001034434A JP 2002112793 A JP2002112793 A JP 2002112793A
- Authority
- JP
- Japan
- Prior art keywords
- leu
- ser
- protein
- ala
- val
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
Abstract
(57)【要約】
【課題】 生体内情報伝達機構の発見や新規薬物標的蛋
白質の同定を可能とすることができる新規Ｇ蛋白質共役
受容体（ＧＰＣＲ）遺伝子やＧＰＣＲ蛋白質をデータベ
ース上で網羅的に検索する方法を提供すること。 【解決手段】 ヒト由来ゲノム情報から２００〜１５０
０のアミノ酸残基からなるオープンリーディングフレー
ム（ＯＲＦ）を抽出し、ＤＮＡの繰返し配列に由来する
ＯＲＦ、不確定なアミノ酸が多いＯＲＦ、及び同一アミ
ノ酸を２０％以上有するＯＲＦを排除し、６〜８個の膜
貫通領域を含むＯＲＦをＳＯＳＵＩを用いて抽出し、得
られたＯＲＦの中から即知のＧＰＣＲ遺伝子とホモロジ
ーを有する遺伝子、好ましくはホモロジー検索における
最もホモロジーの高い遺伝子がＧＰＣＲ遺伝子又はＧＰ
ＣＲ関連遺伝子である遺伝子を検索する。
白質の同定を可能とすることができる新規Ｇ蛋白質共役
受容体（ＧＰＣＲ）遺伝子やＧＰＣＲ蛋白質をデータベ
ース上で網羅的に検索する方法を提供すること。 【解決手段】 ヒト由来ゲノム情報から２００〜１５０
０のアミノ酸残基からなるオープンリーディングフレー
ム（ＯＲＦ）を抽出し、ＤＮＡの繰返し配列に由来する
ＯＲＦ、不確定なアミノ酸が多いＯＲＦ、及び同一アミ
ノ酸を２０％以上有するＯＲＦを排除し、６〜８個の膜
貫通領域を含むＯＲＦをＳＯＳＵＩを用いて抽出し、得
られたＯＲＦの中から即知のＧＰＣＲ遺伝子とホモロジ
ーを有する遺伝子、好ましくはホモロジー検索における
最もホモロジーの高い遺伝子がＧＰＣＲ遺伝子又はＧＰ
ＣＲ関連遺伝子である遺伝子を検索する。
Description
【０００１】
【発明の属する技術分野】本発明は、新規Ｇ蛋白質共役
受容体遺伝子及び新規Ｇ蛋白質共役受容体蛋白質をデー
ターベース上にて網羅的に検索することができる方法
や、かかる方法により得られた新規Ｇ蛋白質共役受容体
遺伝子及び新規Ｇ蛋白質共役受容体や、該遺伝子及び蛋
白質のアゴニスト若しくはアンタゴニスト等の内在性及
び外在性リガンドのスクリーニング方法に関する。
受容体遺伝子及び新規Ｇ蛋白質共役受容体蛋白質をデー
ターベース上にて網羅的に検索することができる方法
や、かかる方法により得られた新規Ｇ蛋白質共役受容体
遺伝子及び新規Ｇ蛋白質共役受容体や、該遺伝子及び蛋
白質のアゴニスト若しくはアンタゴニスト等の内在性及
び外在性リガンドのスクリーニング方法に関する。
【０００２】
【従来の技術】Ｇ蛋白質共役受容体（ＧＰＣＲ：G prot
ein-coupled receptor）は、細胞膜上に存在し、細胞外
からのいろいろな情報を受け取る蛋白質である。ＧＰＣ
Ｒは膜を７回貫通するという共通構造をもつスーパーフ
ァミリーを形成しており、その一つひとつが光、匂い、
味といった感覚のセンサーとして働いたり、ホルモン、
神経伝達物質、生理活性物質、局所仲介物質等の細胞外
リガンドと結合することによって、これら受容体のコン
ホメーションを変化させて、Ｇｉ、Ｇｔ、Ｇｓ、Ｇｏ、
Ｇｑ、Ｇ12等のＧ蛋白質（GTP-binding protein）を活
性化して、細胞内にシグナルを伝達することが知られて
いる。また、各種生体の細胞内や臓器内の複雑な機能を
調節する細胞外リガンドは、生体機能を調節する医薬品
として活用されており、現在使用されている臨床薬の３
０〜５０％はＧＰＣＲを標的とするリガンドと考えられ
ている。近年の遺伝子クローニング技術の発達により、
そのリガンドが同定されていない“Ｏｒｐｈａｎ ＧＰ
ＣＲ”の遺伝子が数多く見つかっており、新規ＧＰＣＲ
の探索やその機能解明が求められており、かかる新規Ｇ
ＰＣＲ遺伝子をクローニングすることは、アゴニストや
アンタゴニストなどのＧＰＣＲに特異的なリガンドの探
索に有用であることが知られている。しかし、ＧＰＣＲ
はその全てが明らかとされているわけではない。
ein-coupled receptor）は、細胞膜上に存在し、細胞外
からのいろいろな情報を受け取る蛋白質である。ＧＰＣ
Ｒは膜を７回貫通するという共通構造をもつスーパーフ
ァミリーを形成しており、その一つひとつが光、匂い、
味といった感覚のセンサーとして働いたり、ホルモン、
神経伝達物質、生理活性物質、局所仲介物質等の細胞外
リガンドと結合することによって、これら受容体のコン
ホメーションを変化させて、Ｇｉ、Ｇｔ、Ｇｓ、Ｇｏ、
Ｇｑ、Ｇ12等のＧ蛋白質（GTP-binding protein）を活
性化して、細胞内にシグナルを伝達することが知られて
いる。また、各種生体の細胞内や臓器内の複雑な機能を
調節する細胞外リガンドは、生体機能を調節する医薬品
として活用されており、現在使用されている臨床薬の３
０〜５０％はＧＰＣＲを標的とするリガンドと考えられ
ている。近年の遺伝子クローニング技術の発達により、
そのリガンドが同定されていない“Ｏｒｐｈａｎ ＧＰ
ＣＲ”の遺伝子が数多く見つかっており、新規ＧＰＣＲ
の探索やその機能解明が求められており、かかる新規Ｇ
ＰＣＲ遺伝子をクローニングすることは、アゴニストや
アンタゴニストなどのＧＰＣＲに特異的なリガンドの探
索に有用であることが知られている。しかし、ＧＰＣＲ
はその全てが明らかとされているわけではない。
【０００３】他方、ＳＯＳＵＩ（http://sosui.proteom
e.bio.tuat.ac.jp/sosuiframe0.html）は蛋白質の一次
構造からアミノ酸ごとの疎水性パラメーターなどを利用
して、その膜貫通領域を予想するために開発されたプロ
グラムである。すでに数多くの既知、および未知の蛋白
質においてその構造予測に適応され、さらにゲノム遺伝
子配列上で膜結合型蛋白質をコードする翻訳領域（ＯＲ
Ｆ：open reading frame）を同定することなどに利用さ
れている。
e.bio.tuat.ac.jp/sosuiframe0.html）は蛋白質の一次
構造からアミノ酸ごとの疎水性パラメーターなどを利用
して、その膜貫通領域を予想するために開発されたプロ
グラムである。すでに数多くの既知、および未知の蛋白
質においてその構造予測に適応され、さらにゲノム遺伝
子配列上で膜結合型蛋白質をコードする翻訳領域（ＯＲ
Ｆ：open reading frame）を同定することなどに利用さ
れている。
【０００４】
【発明が解決しようとする課題】ＧＰＣＲ及びその内在
性リガンドは、これらに作用する薬剤の研究や、当該遺
伝子及びその変異体の遺伝子治療等への応用など、新た
な治療法への応用の可能性が期待される。また、新規Ｇ
ＰＣＲ遺伝子の解析を通して新しい生体内情報伝達機構
の発見や新規薬物標的蛋白質の同定も期待できる。本発
明の課題は、生体内情報伝達機構の発見や新規薬物標的
蛋白質の同定を可能とすることができる新規ＧＰＣＲ遺
伝子やＧＰＣＲ蛋白質をデータベース上で網羅的に検索
する方法を提供することにある。
性リガンドは、これらに作用する薬剤の研究や、当該遺
伝子及びその変異体の遺伝子治療等への応用など、新た
な治療法への応用の可能性が期待される。また、新規Ｇ
ＰＣＲ遺伝子の解析を通して新しい生体内情報伝達機構
の発見や新規薬物標的蛋白質の同定も期待できる。本発
明の課題は、生体内情報伝達機構の発見や新規薬物標的
蛋白質の同定を可能とすることができる新規ＧＰＣＲ遺
伝子やＧＰＣＲ蛋白質をデータベース上で網羅的に検索
する方法を提供することにある。
【０００５】
【課題を解決するための手段】上記課題を解決するため
に、本発明者らは、データベース上で網羅的にＧＰＣＲ
遺伝子を検索することができないかと試行錯誤した結
果、ＧＰＣＲが膜を７回貫通するという構造的な特徴を
持つこと及び多くの既知ＧＰＣＲ遺伝子が翻訳領域（Ｏ
ＲＦ：Open Reading Frame）にイントロンをもたないこ
とを利用して、ヒトゲノム情報からＧＰＣＲ遺伝子の候
補となりうる翻訳領域を抽出し、ＳＯＳＵＩによる分析
を行った。また、ゲノム配列中の確定されていない塩基
については、アミノ酸に翻訳する際に可能性のあるアミ
ノ酸のなかで最も膜貫通領域になりやすいアミノ酸に翻
訳されるようにした。ＳＯＳＵＩを用いた解析ではＧＰ
ＣＲのシグナルペプチドが膜貫通領域として判定される
可能性があり、またＧＰＣＲ構造上で７回目の膜貫通領
域は疎水性が低い傾向があるので、ＳＯＳＵＩで膜貫通
領域と判定できない可能性が考えられる。これらのこと
を考慮して、膜貫通領域が６個〜８個含むと予想された
ＯＲＦを最終的にＧＰＣＲの候補とし、これらの候補遺
伝子を既知のＧＰＣＲ遺伝子と相同性を調べることによ
り、新規ＧＰＣＲ遺伝子を同定できることを見い出し、
本発明を完成するに至った。
に、本発明者らは、データベース上で網羅的にＧＰＣＲ
遺伝子を検索することができないかと試行錯誤した結
果、ＧＰＣＲが膜を７回貫通するという構造的な特徴を
持つこと及び多くの既知ＧＰＣＲ遺伝子が翻訳領域（Ｏ
ＲＦ：Open Reading Frame）にイントロンをもたないこ
とを利用して、ヒトゲノム情報からＧＰＣＲ遺伝子の候
補となりうる翻訳領域を抽出し、ＳＯＳＵＩによる分析
を行った。また、ゲノム配列中の確定されていない塩基
については、アミノ酸に翻訳する際に可能性のあるアミ
ノ酸のなかで最も膜貫通領域になりやすいアミノ酸に翻
訳されるようにした。ＳＯＳＵＩを用いた解析ではＧＰ
ＣＲのシグナルペプチドが膜貫通領域として判定される
可能性があり、またＧＰＣＲ構造上で７回目の膜貫通領
域は疎水性が低い傾向があるので、ＳＯＳＵＩで膜貫通
領域と判定できない可能性が考えられる。これらのこと
を考慮して、膜貫通領域が６個〜８個含むと予想された
ＯＲＦを最終的にＧＰＣＲの候補とし、これらの候補遺
伝子を既知のＧＰＣＲ遺伝子と相同性を調べることによ
り、新規ＧＰＣＲ遺伝子を同定できることを見い出し、
本発明を完成するに至った。
【０００６】すなわち本発明は、ヒト由来ゲノム情報か
ら２００〜１５００のアミノ酸残基からなり、６〜８個
の膜貫通領域を含むオープンリーディングフレームを抽
出し、得られたオープンリーディングフレームの中から
既知のＧ蛋白質共役受容体遺伝子とホモロジーを有する
遺伝子を検索することを特徴とするＧ蛋白質共役受容体
遺伝子及び／又はＧ蛋白質共役受容体蛋白質の検索方法
（請求項１）や、オープンリーディングフレームを抽出
するに際して、ＤＮＡの繰返し配列に由来するオープン
リーディングフレーム、不確定なアミノ酸が多いオープ
ンリーディングフレーム、及び同一アミノ酸を２０％以
上有するオープンリーディングフレームを排除すること
を特徴とする請求項１記載のＧ蛋白質共役受容体遺伝子
及び／又はＧ蛋白質共役受容体蛋白質の検索方法（請求
項２）や、既知のＧ蛋白質共役受容体遺伝子とホモロジ
ーを有する遺伝子が、Ｇ蛋白質共役受容体遺伝子又はＧ
蛋白質共役受容体関連遺伝子であることを特徴とする請
求項１又は２記載のＧ蛋白質共役受容体遺伝子及び／又
はＧ蛋白質共役受容体蛋白質の検索方法（請求項３）
や、Ｇ蛋白質共役受容体が、内在性リガンドを有するこ
とを特徴とする請求項１〜３のいずれか記載のＧ蛋白質
共役受容体遺伝子及び／又はＧ蛋白質共役受容体蛋白質
の検索方法（請求項４）や、内在性リガンドを有するＧ
蛋白質共役受容体が、嗅覚受容体及び味覚受容体以外の
Ｇ蛋白質共役受容体であることを特徴とする請求項４記
載のＧ蛋白質共役受容体遺伝子及び／又はＧ蛋白質共役
受容体蛋白質の検索方法（請求項５）や、内在性リガン
ドを有するＧ蛋白質共役受容体が、嗅覚受容体のＧ蛋白
質共役受容体であることを特徴とする請求項４記載のＧ
蛋白質共役受容体遺伝子及び／又はＧ蛋白質共役受容体
蛋白質の検索方法（請求項６）や、内在性リガンドを有
するＧ蛋白質共役受容体が、味覚受容体のＧ蛋白質共役
受容体であることを特徴とする請求項４記載のＧ蛋白質
共役受容体遺伝子及び／又はＧ蛋白質共役受容体蛋白質
の検索方法（請求項７）に関する。
ら２００〜１５００のアミノ酸残基からなり、６〜８個
の膜貫通領域を含むオープンリーディングフレームを抽
出し、得られたオープンリーディングフレームの中から
既知のＧ蛋白質共役受容体遺伝子とホモロジーを有する
遺伝子を検索することを特徴とするＧ蛋白質共役受容体
遺伝子及び／又はＧ蛋白質共役受容体蛋白質の検索方法
（請求項１）や、オープンリーディングフレームを抽出
するに際して、ＤＮＡの繰返し配列に由来するオープン
リーディングフレーム、不確定なアミノ酸が多いオープ
ンリーディングフレーム、及び同一アミノ酸を２０％以
上有するオープンリーディングフレームを排除すること
を特徴とする請求項１記載のＧ蛋白質共役受容体遺伝子
及び／又はＧ蛋白質共役受容体蛋白質の検索方法（請求
項２）や、既知のＧ蛋白質共役受容体遺伝子とホモロジ
ーを有する遺伝子が、Ｇ蛋白質共役受容体遺伝子又はＧ
蛋白質共役受容体関連遺伝子であることを特徴とする請
求項１又は２記載のＧ蛋白質共役受容体遺伝子及び／又
はＧ蛋白質共役受容体蛋白質の検索方法（請求項３）
や、Ｇ蛋白質共役受容体が、内在性リガンドを有するこ
とを特徴とする請求項１〜３のいずれか記載のＧ蛋白質
共役受容体遺伝子及び／又はＧ蛋白質共役受容体蛋白質
の検索方法（請求項４）や、内在性リガンドを有するＧ
蛋白質共役受容体が、嗅覚受容体及び味覚受容体以外の
Ｇ蛋白質共役受容体であることを特徴とする請求項４記
載のＧ蛋白質共役受容体遺伝子及び／又はＧ蛋白質共役
受容体蛋白質の検索方法（請求項５）や、内在性リガン
ドを有するＧ蛋白質共役受容体が、嗅覚受容体のＧ蛋白
質共役受容体であることを特徴とする請求項４記載のＧ
蛋白質共役受容体遺伝子及び／又はＧ蛋白質共役受容体
蛋白質の検索方法（請求項６）や、内在性リガンドを有
するＧ蛋白質共役受容体が、味覚受容体のＧ蛋白質共役
受容体であることを特徴とする請求項４記載のＧ蛋白質
共役受容体遺伝子及び／又はＧ蛋白質共役受容体蛋白質
の検索方法（請求項７）に関する。
【０００７】また本発明は、請求項１〜７のいずれか記
載のＧ蛋白質共役受容体遺伝子及び／又はＧ蛋白質共役
受容体蛋白質の検索方法により得られることを特徴とす
るＧ蛋白質共役受容体遺伝子（請求項８）や、以下の
(ａ)又は(ｂ)のＧ蛋白質共役受容体蛋白質をコードする
遺伝子(ａ)配列番号２ｎ（ｎ＝１から５１までのいずれ
かの整数を示す）に示されるアミノ酸配列からなるＧ蛋
白質共役受容体蛋白質(ｂ) 配列番号２ｎ（ｎ＝１から
５１までのいずれかの整数を示す）に示されるアミノ酸
配列において、１若しくは数個のアミノ酸が欠失、置換
若しくは付加されたアミノ酸配列からなるＧ蛋白質共役
受容体蛋白質（請求項９）や、配列番号２ｎ−１（ｎ＝
１から５１までのいずれかの整数を示す）に示される塩
基配列又はその相補的配列並びにこれらの配列の一部ま
たは全部を含むＤＮＡからなるＧ蛋白質共役受容体蛋白
質をコードするＤＮＡ（請求項１０）や、請求項１０記
載の遺伝子を構成するＤＮＡとストリンジェントな条件
下でハイブリダイズし、かつＧ蛋白質共役受容体蛋白質
をコードするＤＮＡ（請求項１１）や、以下の(ａ)又は
(ｂ)のＧ蛋白質共役受容体蛋白質をコードする遺伝子
(ａ)配列番号２ｎ（ｎ＝５２から３３２までのいずれか
の整数を示す）に示されるアミノ酸配列からなるＧ蛋白
質共役受容体蛋白質(ｂ) 配列番号２ｎ（ｎ＝５２から
３３２までのいずれかの整数を示す）に示されるアミノ
酸配列において、１若しくは数個のアミノ酸が欠失、置
換若しくは付加されたアミノ酸配列からなるＧ蛋白質共
役受容体蛋白質（請求項１２）や、配列番号２ｎ−１
（ｎ＝５２から３３２までのいずれかの整数を示す）に
示される塩基配列又はその相補的配列並びにこれらの配
列の一部または全部を含むＤＮＡからなるＧ蛋白質共役
受容体蛋白質をコードするＤＮＡ（請求項１３）や、請
求項１３記載の遺伝子を構成するＤＮＡとストリンジェ
ントな条件下でハイブリダイズし、かつＧ蛋白質共役受
容体蛋白質をコードするＤＮＡ（請求項１４）や、以下
の(ａ)又は(ｂ)のＧ蛋白質共役受容体蛋白質をコードす
る遺伝子(ａ)配列番号２ｎ（ｎ＝３３３から３４７まで
のいずれかの整数を示す）に示されるアミノ酸配列から
なるＧ蛋白質共役受容体蛋白質(ｂ) 配列番号２ｎ（ｎ
＝３３３から３４７までのいずれかの整数を示す）に示
されるアミノ酸配列において、１若しくは数個のアミノ
酸が欠失、置換若しくは付加されたアミノ酸配列からな
るＧ蛋白質共役受容体蛋白質（請求項１５）や、配列番
号２ｎ−１（ｎ＝３３３から３４７までのいずれかの整
数を示す）に示される塩基配列又はその相補的配列並び
にこれらの配列の一部または全部を含むＤＮＡからなる
Ｇ蛋白質共役受容体蛋白質をコードするＤＮＡ（請求項
１６）や、請求項１６記載の遺伝子を構成するＤＮＡと
ストリンジェントな条件下でハイブリダイズし、かつＧ
蛋白質共役受容体蛋白質をコードするＤＮＡ（請求項１
７）に関する。
載のＧ蛋白質共役受容体遺伝子及び／又はＧ蛋白質共役
受容体蛋白質の検索方法により得られることを特徴とす
るＧ蛋白質共役受容体遺伝子（請求項８）や、以下の
(ａ)又は(ｂ)のＧ蛋白質共役受容体蛋白質をコードする
遺伝子(ａ)配列番号２ｎ（ｎ＝１から５１までのいずれ
かの整数を示す）に示されるアミノ酸配列からなるＧ蛋
白質共役受容体蛋白質(ｂ) 配列番号２ｎ（ｎ＝１から
５１までのいずれかの整数を示す）に示されるアミノ酸
配列において、１若しくは数個のアミノ酸が欠失、置換
若しくは付加されたアミノ酸配列からなるＧ蛋白質共役
受容体蛋白質（請求項９）や、配列番号２ｎ−１（ｎ＝
１から５１までのいずれかの整数を示す）に示される塩
基配列又はその相補的配列並びにこれらの配列の一部ま
たは全部を含むＤＮＡからなるＧ蛋白質共役受容体蛋白
質をコードするＤＮＡ（請求項１０）や、請求項１０記
載の遺伝子を構成するＤＮＡとストリンジェントな条件
下でハイブリダイズし、かつＧ蛋白質共役受容体蛋白質
をコードするＤＮＡ（請求項１１）や、以下の(ａ)又は
(ｂ)のＧ蛋白質共役受容体蛋白質をコードする遺伝子
(ａ)配列番号２ｎ（ｎ＝５２から３３２までのいずれか
の整数を示す）に示されるアミノ酸配列からなるＧ蛋白
質共役受容体蛋白質(ｂ) 配列番号２ｎ（ｎ＝５２から
３３２までのいずれかの整数を示す）に示されるアミノ
酸配列において、１若しくは数個のアミノ酸が欠失、置
換若しくは付加されたアミノ酸配列からなるＧ蛋白質共
役受容体蛋白質（請求項１２）や、配列番号２ｎ−１
（ｎ＝５２から３３２までのいずれかの整数を示す）に
示される塩基配列又はその相補的配列並びにこれらの配
列の一部または全部を含むＤＮＡからなるＧ蛋白質共役
受容体蛋白質をコードするＤＮＡ（請求項１３）や、請
求項１３記載の遺伝子を構成するＤＮＡとストリンジェ
ントな条件下でハイブリダイズし、かつＧ蛋白質共役受
容体蛋白質をコードするＤＮＡ（請求項１４）や、以下
の(ａ)又は(ｂ)のＧ蛋白質共役受容体蛋白質をコードす
る遺伝子(ａ)配列番号２ｎ（ｎ＝３３３から３４７まで
のいずれかの整数を示す）に示されるアミノ酸配列から
なるＧ蛋白質共役受容体蛋白質(ｂ) 配列番号２ｎ（ｎ
＝３３３から３４７までのいずれかの整数を示す）に示
されるアミノ酸配列において、１若しくは数個のアミノ
酸が欠失、置換若しくは付加されたアミノ酸配列からな
るＧ蛋白質共役受容体蛋白質（請求項１５）や、配列番
号２ｎ−１（ｎ＝３３３から３４７までのいずれかの整
数を示す）に示される塩基配列又はその相補的配列並び
にこれらの配列の一部または全部を含むＤＮＡからなる
Ｇ蛋白質共役受容体蛋白質をコードするＤＮＡ（請求項
１６）や、請求項１６記載の遺伝子を構成するＤＮＡと
ストリンジェントな条件下でハイブリダイズし、かつＧ
蛋白質共役受容体蛋白質をコードするＤＮＡ（請求項１
７）に関する。
【０００８】また本発明は、請求項１〜７のいずれか記
載のＧ蛋白質共役受容体遺伝子及び／又はＧ蛋白質共役
受容体蛋白質の検索方法により得られることを特徴とす
るＧ蛋白質共役受容体蛋白質（請求項１８）や、配列番
号２ｎ（ｎ＝１から５１までのいずれかの整数を示す）
に示されるアミノ酸配列からなるＧ蛋白質共役受容体蛋
白質（請求項１９）や、配列番号２ｎ（ｎ＝１から５１
までのいずれかの整数を示す）に示されるアミノ酸配列
において、１若しくは数個のアミノ酸が欠失、置換若し
くは付加されたアミノ酸配列からなるＧ蛋白質共役受容
体蛋白質（請求項２０）や、配列番号２ｎ（ｎ＝５２か
ら３３２までのいずれかの整数を示す）に示されるアミ
ノ酸配列からなるＧ蛋白質共役受容体蛋白質（請求項２
１）や、配列番号２ｎ（ｎ＝５２から３３２までのいず
れかの整数を示す）に示されるアミノ酸配列において、
１若しくは数個のアミノ酸が欠失、置換若しくは付加さ
れたアミノ酸配列からなるＧ蛋白質共役受容体蛋白質
（請求項２２）や、配列番号２ｎ（ｎ＝３３３から３４
７までのいずれかの整数を示す）に示されるアミノ酸配
列からなるＧ蛋白質共役受容体蛋白質（請求項２３）
や、配列番号２ｎ（ｎ＝３３３から３４７までのいずれ
かの整数を示す）に示されるアミノ酸配列において、１
若しくは数個のアミノ酸が欠失、置換若しくは付加され
たアミノ酸配列からなるＧ蛋白質共役受容体蛋白質（請
求項２４）や、請求項１〜７のいずれか記載のＧ蛋白質
共役受容体遺伝子及び／又はＧ蛋白質共役受容体蛋白質
の検索方法により得られるＧ蛋白質共役受容体蛋白質の
部分ペプチド（請求項２５）や、Ｇ蛋白質共役受容体蛋
白質が、請求項１９〜２４のいずれか記載のＧ蛋白質共
役受容体蛋白質であることを特徴とする請求項２５記載
の部分ペプチド（請求項２６）に関する。
載のＧ蛋白質共役受容体遺伝子及び／又はＧ蛋白質共役
受容体蛋白質の検索方法により得られることを特徴とす
るＧ蛋白質共役受容体蛋白質（請求項１８）や、配列番
号２ｎ（ｎ＝１から５１までのいずれかの整数を示す）
に示されるアミノ酸配列からなるＧ蛋白質共役受容体蛋
白質（請求項１９）や、配列番号２ｎ（ｎ＝１から５１
までのいずれかの整数を示す）に示されるアミノ酸配列
において、１若しくは数個のアミノ酸が欠失、置換若し
くは付加されたアミノ酸配列からなるＧ蛋白質共役受容
体蛋白質（請求項２０）や、配列番号２ｎ（ｎ＝５２か
ら３３２までのいずれかの整数を示す）に示されるアミ
ノ酸配列からなるＧ蛋白質共役受容体蛋白質（請求項２
１）や、配列番号２ｎ（ｎ＝５２から３３２までのいず
れかの整数を示す）に示されるアミノ酸配列において、
１若しくは数個のアミノ酸が欠失、置換若しくは付加さ
れたアミノ酸配列からなるＧ蛋白質共役受容体蛋白質
（請求項２２）や、配列番号２ｎ（ｎ＝３３３から３４
７までのいずれかの整数を示す）に示されるアミノ酸配
列からなるＧ蛋白質共役受容体蛋白質（請求項２３）
や、配列番号２ｎ（ｎ＝３３３から３４７までのいずれ
かの整数を示す）に示されるアミノ酸配列において、１
若しくは数個のアミノ酸が欠失、置換若しくは付加され
たアミノ酸配列からなるＧ蛋白質共役受容体蛋白質（請
求項２４）や、請求項１〜７のいずれか記載のＧ蛋白質
共役受容体遺伝子及び／又はＧ蛋白質共役受容体蛋白質
の検索方法により得られるＧ蛋白質共役受容体蛋白質の
部分ペプチド（請求項２５）や、Ｇ蛋白質共役受容体蛋
白質が、請求項１９〜２４のいずれか記載のＧ蛋白質共
役受容体蛋白質であることを特徴とする請求項２５記載
の部分ペプチド（請求項２６）に関する。
【０００９】また本発明は、請求項１８記載のＧ蛋白質
共役受容体蛋白質又は請求項２５記載のＧ蛋白質共役受
容体蛋白質の部分ペプチドと、マーカー蛋白質及び／又
はペプチドタグとを結合させた融合蛋白質又は融合ペプ
チド（請求項２７）や、Ｇ蛋白質共役受容体蛋白質が、
請求項１９〜２４のいずれか記載のＧ蛋白質共役受容体
蛋白質であることを特徴とする請求項２７記載の融合蛋
白質（請求項２８）や、請求項１８記載のＧ蛋白質共役
受容体蛋白質に特異的に結合する抗体（請求項２９）
や、Ｇ蛋白質共役受容体蛋白質が、請求項１９〜２４の
いずれか記載のＧ蛋白質共役受容体蛋白質であることを
特徴とする請求項２９記載の抗体（請求項３０）や、請
求項１８記載のＧ蛋白質共役受容体蛋白質を発現するこ
とができる発現系を含んでなる宿主細胞（請求項３１）
や、Ｇ蛋白質共役受容体蛋白質が、請求項１９〜２４の
いずれか記載のＧ蛋白質共役受容体蛋白質であることを
特徴とする請求項３１記載の宿主細胞（請求項３２）
や、請求項１８記載のＧ蛋白質共役受容体蛋白質をコー
ドする遺伝子機能が染色体上で欠損し又は前記蛋白質が
過剰発現することを特徴とする非ヒト動物（請求項３
３）や、Ｇ蛋白質共役受容体蛋白質が、請求項１９〜２
４のいずれか記載のＧ蛋白質共役受容体蛋白質であるこ
とを特徴とする請求項３３記載の非ヒト動物（請求項３
４）や、非ヒト動物がマウスであることを特徴とする請
求項３３又は３４記載の非ヒト動物（請求項３５）に関
する。
共役受容体蛋白質又は請求項２５記載のＧ蛋白質共役受
容体蛋白質の部分ペプチドと、マーカー蛋白質及び／又
はペプチドタグとを結合させた融合蛋白質又は融合ペプ
チド（請求項２７）や、Ｇ蛋白質共役受容体蛋白質が、
請求項１９〜２４のいずれか記載のＧ蛋白質共役受容体
蛋白質であることを特徴とする請求項２７記載の融合蛋
白質（請求項２８）や、請求項１８記載のＧ蛋白質共役
受容体蛋白質に特異的に結合する抗体（請求項２９）
や、Ｇ蛋白質共役受容体蛋白質が、請求項１９〜２４の
いずれか記載のＧ蛋白質共役受容体蛋白質であることを
特徴とする請求項２９記載の抗体（請求項３０）や、請
求項１８記載のＧ蛋白質共役受容体蛋白質を発現するこ
とができる発現系を含んでなる宿主細胞（請求項３１）
や、Ｇ蛋白質共役受容体蛋白質が、請求項１９〜２４の
いずれか記載のＧ蛋白質共役受容体蛋白質であることを
特徴とする請求項３１記載の宿主細胞（請求項３２）
や、請求項１８記載のＧ蛋白質共役受容体蛋白質をコー
ドする遺伝子機能が染色体上で欠損し又は前記蛋白質が
過剰発現することを特徴とする非ヒト動物（請求項３
３）や、Ｇ蛋白質共役受容体蛋白質が、請求項１９〜２
４のいずれか記載のＧ蛋白質共役受容体蛋白質であるこ
とを特徴とする請求項３３記載の非ヒト動物（請求項３
４）や、非ヒト動物がマウスであることを特徴とする請
求項３３又は３４記載の非ヒト動物（請求項３５）に関
する。
【００１０】また本発明は、請求項１８〜２４のいずれ
か記載のＧ蛋白質共役受容体蛋白質、請求項２５若しく
は２６記載の部分ペプチド、又は前記蛋白質若しくは部
分ペプチドを発現している細胞の膜と、被検物質とを用
いることを特徴とするＧ蛋白質共役受容体の機能促進若
しくは抑制物質又はＧ蛋白質共役受容体の発現促進若し
くは抑制物質のスクリーニング方法（請求項３６）や、
請求項１８〜２４のいずれか記載のＧ蛋白質共役受容体
蛋白質、請求項２５若しくは２６記載の部分ペプチド、
又は前記蛋白質若しくは部分ペプチドを発現している細
胞の膜と、Ｇ蛋白質又はＧ蛋白質の部分ペプチドと、被
検物質とを用いることを特徴とするＧ蛋白質共役受容体
の機能促進若しくは抑制物質又はＧ蛋白質共役受容体の
発現促進若しくは抑制物質のスクリーニング方法（請求
項３７）や、請求項１８〜２４のいずれか記載のＧ蛋白
質共役受容体蛋白質又は請求項２５若しくは２６記載の
部分ペプチドを発現している細胞と、被検物質とを用い
ることを特徴とするＧ蛋白質共役受容体の機能促進若し
くは抑制物質又はＧ蛋白質共役受容体の発現促進若しく
は抑制物質のスクリーニング方法（請求項３８）や、請
求項１８〜２４のいずれか記載のＧ蛋白質共役受容体蛋
白質又は請求項２５若しくは２６記載の部分ペプチドを
発現している細胞が、請求項３１又は３２記載の宿主細
胞であることを特徴とする請求項３６〜３８のいずれか
記載のＧ蛋白質共役受容体の機能促進若しくは抑制物質
又はＧ蛋白質共役受容体の発現促進若しくは抑制物質の
スクリーニング方法（請求項３９）や、請求項３３〜３
５のいずれか記載の非ヒト動物と、被検物質とを用いる
ことを特徴とするＧ蛋白質共役受容体の機能促進若しく
は抑制物質又はＧ蛋白質共役受容体の発現促進若しくは
抑制物質のスクリーニング方法（請求項４０）に関す
る。
か記載のＧ蛋白質共役受容体蛋白質、請求項２５若しく
は２６記載の部分ペプチド、又は前記蛋白質若しくは部
分ペプチドを発現している細胞の膜と、被検物質とを用
いることを特徴とするＧ蛋白質共役受容体の機能促進若
しくは抑制物質又はＧ蛋白質共役受容体の発現促進若し
くは抑制物質のスクリーニング方法（請求項３６）や、
請求項１８〜２４のいずれか記載のＧ蛋白質共役受容体
蛋白質、請求項２５若しくは２６記載の部分ペプチド、
又は前記蛋白質若しくは部分ペプチドを発現している細
胞の膜と、Ｇ蛋白質又はＧ蛋白質の部分ペプチドと、被
検物質とを用いることを特徴とするＧ蛋白質共役受容体
の機能促進若しくは抑制物質又はＧ蛋白質共役受容体の
発現促進若しくは抑制物質のスクリーニング方法（請求
項３７）や、請求項１８〜２４のいずれか記載のＧ蛋白
質共役受容体蛋白質又は請求項２５若しくは２６記載の
部分ペプチドを発現している細胞と、被検物質とを用い
ることを特徴とするＧ蛋白質共役受容体の機能促進若し
くは抑制物質又はＧ蛋白質共役受容体の発現促進若しく
は抑制物質のスクリーニング方法（請求項３８）や、請
求項１８〜２４のいずれか記載のＧ蛋白質共役受容体蛋
白質又は請求項２５若しくは２６記載の部分ペプチドを
発現している細胞が、請求項３１又は３２記載の宿主細
胞であることを特徴とする請求項３６〜３８のいずれか
記載のＧ蛋白質共役受容体の機能促進若しくは抑制物質
又はＧ蛋白質共役受容体の発現促進若しくは抑制物質の
スクリーニング方法（請求項３９）や、請求項３３〜３
５のいずれか記載の非ヒト動物と、被検物質とを用いる
ことを特徴とするＧ蛋白質共役受容体の機能促進若しく
は抑制物質又はＧ蛋白質共役受容体の発現促進若しくは
抑制物質のスクリーニング方法（請求項４０）に関す
る。
【００１１】また本発明は、請求項３６〜４０のいずれ
か記載のＧ蛋白質共役受容体の機能促進若しくは抑制物
質又はＧ蛋白質共役受容体の発現促進若しくは抑制物質
のスクリーニング方法により得られることを特徴とする
Ｇ蛋白質共役受容体の機能促進若しくは抑制物質又はＧ
蛋白質共役受容体の発現促進若しくは抑制物質（請求項
４１）や、Ｇ蛋白質共役受容体の機能促進若しくは抑制
物質又はＧ蛋白質共役受容体の発現促進若しくは抑制物
質が、Ｇ蛋白質共役受容体のリガンドであることを特徴
とする請求項４１記載のＧ蛋白質共役受容体の機能促進
若しくは抑制物質又はＧ蛋白質共役受容体の発現促進若
しくは抑制物質（請求項４２）や、Ｇ蛋白質共役受容体
の機能促進又は発現増強を必要としている患者を治療す
るのに用いられる医薬組成物であって、有効成分として
請求項１８〜２４のいずれか記載の蛋白質、請求項２５
若しくは２６記載の部分ペプチド、又は請求項４１若し
くは４２記載のＧ蛋白質共役受容体の機能又は発現を促
進する物質を含んでなる医薬組成物（請求項４３）や、
Ｇ蛋白質共役受容体の機能又は発現の抑制を必要として
いる患者を治療するのに用いられる医薬組成物であっ
て、有効成分として請求項１８〜２４のいずれか記載の
蛋白質、請求項２５若しくは２６記載の部分ペプチド、
又は請求項４１若しくは４２記載のＧ蛋白質共役受容体
の機能又は発現を抑制する物質を含んでなる医薬組成物
（請求項４４）に関する。
か記載のＧ蛋白質共役受容体の機能促進若しくは抑制物
質又はＧ蛋白質共役受容体の発現促進若しくは抑制物質
のスクリーニング方法により得られることを特徴とする
Ｇ蛋白質共役受容体の機能促進若しくは抑制物質又はＧ
蛋白質共役受容体の発現促進若しくは抑制物質（請求項
４１）や、Ｇ蛋白質共役受容体の機能促進若しくは抑制
物質又はＧ蛋白質共役受容体の発現促進若しくは抑制物
質が、Ｇ蛋白質共役受容体のリガンドであることを特徴
とする請求項４１記載のＧ蛋白質共役受容体の機能促進
若しくは抑制物質又はＧ蛋白質共役受容体の発現促進若
しくは抑制物質（請求項４２）や、Ｇ蛋白質共役受容体
の機能促進又は発現増強を必要としている患者を治療す
るのに用いられる医薬組成物であって、有効成分として
請求項１８〜２４のいずれか記載の蛋白質、請求項２５
若しくは２６記載の部分ペプチド、又は請求項４１若し
くは４２記載のＧ蛋白質共役受容体の機能又は発現を促
進する物質を含んでなる医薬組成物（請求項４３）や、
Ｇ蛋白質共役受容体の機能又は発現の抑制を必要として
いる患者を治療するのに用いられる医薬組成物であっ
て、有効成分として請求項１８〜２４のいずれか記載の
蛋白質、請求項２５若しくは２６記載の部分ペプチド、
又は請求項４１若しくは４２記載のＧ蛋白質共役受容体
の機能又は発現を抑制する物質を含んでなる医薬組成物
（請求項４４）に関する。
【００１２】また本発明は、検体中のＧ蛋白質共役受容
体蛋白質をコードするＤＮＡ配列を、請求項１８〜２４
のいずれか記載の蛋白質をコードするＤＮＡ配列と比較
することを特徴とするＧ蛋白質共役受容体の機能又は発
現に関連する疾病の診断方法（請求項４５）や、請求項
１８〜２４のいずれか記載の蛋白質をコードするＤＮＡ
又はＲＮＡのアンチセンス鎖の全部又は一部からなるＧ
蛋白質共役受容体の機能又は発現に関連する疾病の診断
用プローブ（請求項４６）や、請求項４６記載の診断用
プローブ及び／又は請求項２９又は３０記載の抗体を含
有することを特徴とするＧ蛋白質共役受容体の機能又は
発現に関連する疾病の診断薬（請求項４７）に関する。
体蛋白質をコードするＤＮＡ配列を、請求項１８〜２４
のいずれか記載の蛋白質をコードするＤＮＡ配列と比較
することを特徴とするＧ蛋白質共役受容体の機能又は発
現に関連する疾病の診断方法（請求項４５）や、請求項
１８〜２４のいずれか記載の蛋白質をコードするＤＮＡ
又はＲＮＡのアンチセンス鎖の全部又は一部からなるＧ
蛋白質共役受容体の機能又は発現に関連する疾病の診断
用プローブ（請求項４６）や、請求項４６記載の診断用
プローブ及び／又は請求項２９又は３０記載の抗体を含
有することを特徴とするＧ蛋白質共役受容体の機能又は
発現に関連する疾病の診断薬（請求項４７）に関する。
【００１３】
【発明の実施の形態】本発明のＧＰＣＲ遺伝子及び／又
はＧＰＣＲ蛋白質の検索方法としては、ヒト由来のゲノ
ム情報から２００〜１５００のアミノ酸残基からなり、
６〜８個の膜貫通領域を含むオープンリーディングフレ
ームを抽出し、得られたオープンリーディングフレーム
の中から既知のＧＰＣＲ遺伝子とホモロジーを有する遺
伝子、好ましくはＧＰＣＲ遺伝子又はＧＰＣＲ関連遺伝
子、特に好ましくは内外性リガンドを有するＧＰＣＲの
遺伝子である遺伝子を検索する方法であれば、特に制限
されるものではないが、好ましくはオープンリーディン
グフレームを抽出する際に、ＤＮＡの繰返し配列に由来
するオープンリーディングフレームや不確定なアミノ酸
が多いオープンリーディングフレームや、同一アミノ酸
を２０％以上有するオープンリーディングフレームを排
除することが望ましい。６〜８個の膜貫通領域を含むオ
ープンリーディングフレームの抽出には、例えば前記し
た、蛋白質の一次構造からアミノ酸ごとの疎水性パラメ
ーターなどを利用して、その膜貫通領域を予想するため
に開発されたプログラムであるＳＯＳＵＩ等を用いるこ
とができる。また、ホモロジーを有する遺伝子の検索に
は、ＢＬＡＳＴ等の公知のホモロジー検索システムを用
いることができる。
はＧＰＣＲ蛋白質の検索方法としては、ヒト由来のゲノ
ム情報から２００〜１５００のアミノ酸残基からなり、
６〜８個の膜貫通領域を含むオープンリーディングフレ
ームを抽出し、得られたオープンリーディングフレーム
の中から既知のＧＰＣＲ遺伝子とホモロジーを有する遺
伝子、好ましくはＧＰＣＲ遺伝子又はＧＰＣＲ関連遺伝
子、特に好ましくは内外性リガンドを有するＧＰＣＲの
遺伝子である遺伝子を検索する方法であれば、特に制限
されるものではないが、好ましくはオープンリーディン
グフレームを抽出する際に、ＤＮＡの繰返し配列に由来
するオープンリーディングフレームや不確定なアミノ酸
が多いオープンリーディングフレームや、同一アミノ酸
を２０％以上有するオープンリーディングフレームを排
除することが望ましい。６〜８個の膜貫通領域を含むオ
ープンリーディングフレームの抽出には、例えば前記し
た、蛋白質の一次構造からアミノ酸ごとの疎水性パラメ
ーターなどを利用して、その膜貫通領域を予想するため
に開発されたプログラムであるＳＯＳＵＩ等を用いるこ
とができる。また、ホモロジーを有する遺伝子の検索に
は、ＢＬＡＳＴ等の公知のホモロジー検索システムを用
いることができる。
【００１４】本発明のＧＰＣＲ遺伝子としては、上記ホ
モロジー検索により得られるＧＰＣＲ遺伝子であればど
のようなものでもよく、例えば、配列番号２ｎ（ｎ＝１
から５１までのいずれかの整数を示す）に示されるアミ
ノ酸配列からなる嗅覚受容体及び味覚受容体以外のＧＰ
ＣＲ蛋白質をコードする遺伝子や、配列番号２ｎ（ｎ＝
５２から３３２までのいずれかの整数を示す）に示され
るアミノ酸配列からなる嗅覚受容体のＧＰＣＲ蛋白質を
コードする遺伝子や、配列番号２ｎ（ｎ＝３３３から３
４７までのいずれかの整数を示す）に示されるアミノ酸
配列からなる味覚受容体のＧＰＣＲ蛋白質をコードする
遺伝子や、配列番号２ｎ（ｎ＝１から３４７までのいず
れかの整数を示す）に示されるアミノ酸配列において、
１若しくは数個のアミノ酸が欠失、置換若しくは付加さ
れたアミノ酸配列からなるＧＰＣＲ蛋白質をコードする
遺伝子等を挙げることができ、これらＧＰＣＲ遺伝子は
そのＤＮＡ配列情報等に基づき、例えばヒト由来のＧＰ
ＣＲ遺伝子においてはヒト遺伝子ライブラリーやヒトｃ
ＤＮＡライブラリーなどから公知の方法により調製する
ことができる。
モロジー検索により得られるＧＰＣＲ遺伝子であればど
のようなものでもよく、例えば、配列番号２ｎ（ｎ＝１
から５１までのいずれかの整数を示す）に示されるアミ
ノ酸配列からなる嗅覚受容体及び味覚受容体以外のＧＰ
ＣＲ蛋白質をコードする遺伝子や、配列番号２ｎ（ｎ＝
５２から３３２までのいずれかの整数を示す）に示され
るアミノ酸配列からなる嗅覚受容体のＧＰＣＲ蛋白質を
コードする遺伝子や、配列番号２ｎ（ｎ＝３３３から３
４７までのいずれかの整数を示す）に示されるアミノ酸
配列からなる味覚受容体のＧＰＣＲ蛋白質をコードする
遺伝子や、配列番号２ｎ（ｎ＝１から３４７までのいず
れかの整数を示す）に示されるアミノ酸配列において、
１若しくは数個のアミノ酸が欠失、置換若しくは付加さ
れたアミノ酸配列からなるＧＰＣＲ蛋白質をコードする
遺伝子等を挙げることができ、これらＧＰＣＲ遺伝子は
そのＤＮＡ配列情報等に基づき、例えばヒト由来のＧＰ
ＣＲ遺伝子においてはヒト遺伝子ライブラリーやヒトｃ
ＤＮＡライブラリーなどから公知の方法により調製する
ことができる。
【００１５】本発明のＧＰＣＲ蛋白質をコードするＤＮ
Ａとしては、配列番号２ｎ−１（ｎ＝１から３４７まで
のいずれかの整数を示す）に示される塩基配列又はその
相補的配列並びにこれらの配列の一部又は全部を含むＤ
ＮＡや、これらＤＮＡをプローブとして、各種ＤＮＡラ
イブラリーに対してストリンジェントな条件下でハイブ
リダイゼーションし、かつＧＰＣＲ蛋白質をコードする
ＤＮＡを挙げることができる。かかるＤＮＡを取得する
ためのハイブリダイゼーションの条件としては、例え
ば、４２℃でのハイブリダイゼーション、及び１×ＳＳ
Ｃ、０．１％のＳＤＳを含む緩衝液による４２℃での洗
浄処理を挙げることができ、６５℃でのハイブリダイゼ
ーション、及び０．１×ＳＳＣ，０．１％のＳＤＳを含
む緩衝液による６５℃での洗浄処理をより好ましく挙げ
ることができる。なお、ハイブリダイゼーションのスト
リンジェンシーに影響を与える要素としては、上記温度
条件以外に種々の要素があり、当業者であれば、種々の
要素を適宜組み合わせて、上記例示したハイブリダイゼ
ーションのストリンジェンシーと同等のストリンジェン
シーを実現することが可能である。
Ａとしては、配列番号２ｎ−１（ｎ＝１から３４７まで
のいずれかの整数を示す）に示される塩基配列又はその
相補的配列並びにこれらの配列の一部又は全部を含むＤ
ＮＡや、これらＤＮＡをプローブとして、各種ＤＮＡラ
イブラリーに対してストリンジェントな条件下でハイブ
リダイゼーションし、かつＧＰＣＲ蛋白質をコードする
ＤＮＡを挙げることができる。かかるＤＮＡを取得する
ためのハイブリダイゼーションの条件としては、例え
ば、４２℃でのハイブリダイゼーション、及び１×ＳＳ
Ｃ、０．１％のＳＤＳを含む緩衝液による４２℃での洗
浄処理を挙げることができ、６５℃でのハイブリダイゼ
ーション、及び０．１×ＳＳＣ，０．１％のＳＤＳを含
む緩衝液による６５℃での洗浄処理をより好ましく挙げ
ることができる。なお、ハイブリダイゼーションのスト
リンジェンシーに影響を与える要素としては、上記温度
条件以外に種々の要素があり、当業者であれば、種々の
要素を適宜組み合わせて、上記例示したハイブリダイゼ
ーションのストリンジェンシーと同等のストリンジェン
シーを実現することが可能である。
【００１６】本発明のＧＰＣＲ蛋白質としては、上記ス
クリーニング方法により得られたものであればどのよう
なものでもよく、例えば、配列番号２ｎ（ｎ＝１から５
１までのいずれかの整数を示す）に示されるアミノ酸配
列からなる嗅覚受容体及び味覚受容体以外のＧＰＣＲ蛋
白質や、配列番号２ｎ（ｎ＝５２から３３２までのいず
れかの整数を示す）に示されるアミノ酸配列からなる嗅
覚受容体のＧＰＣＲ蛋白質や、配列番号２ｎ（ｎ＝３３
３から３４７までのいずれかの整数を示す）に示される
アミノ酸配列からなる味覚受容体のＧＰＣＲ蛋白質や、
配列番号２ｎ（ｎ＝１から３４７までのいずれかの整数
を示す）に示されるアミノ酸配列において、１若しくは
数個のアミノ酸が欠失、置換若しくは付加されたアミノ
酸配列からなるＧＰＣＲ蛋白質や、これらの組換え蛋白
質を具体的に挙げることができる。また、本発明の対象
となる上記ＧＰＣＲ蛋白質の部分ペプチドとしては、上
記ＧＰＣＲ蛋白質の一部からなり、かつ各種Ｇ蛋白質を
認識するアミノ酸配列又は各種Ｇ蛋白質と特異的に結合
するアミノ酸配列を有するものであれば特に制限される
ものではない。上記本発明の対象となるＧＰＣＲ蛋白質
及びＧＰＣＲ蛋白質の部分ペプチド、並びにこれら蛋白
質及びペプチドに特異的に結合する抗体が特異的に結合
する組換え蛋白質及びペプチドを総称して、以下「本件
蛋白質・ペプチド」ということがある。なお、本件蛋白
質・ペプチドはそのＤＮＡ配列情報等に基づき公知の方
法で調製することができ、その由来は特に制限されるも
のではない。
クリーニング方法により得られたものであればどのよう
なものでもよく、例えば、配列番号２ｎ（ｎ＝１から５
１までのいずれかの整数を示す）に示されるアミノ酸配
列からなる嗅覚受容体及び味覚受容体以外のＧＰＣＲ蛋
白質や、配列番号２ｎ（ｎ＝５２から３３２までのいず
れかの整数を示す）に示されるアミノ酸配列からなる嗅
覚受容体のＧＰＣＲ蛋白質や、配列番号２ｎ（ｎ＝３３
３から３４７までのいずれかの整数を示す）に示される
アミノ酸配列からなる味覚受容体のＧＰＣＲ蛋白質や、
配列番号２ｎ（ｎ＝１から３４７までのいずれかの整数
を示す）に示されるアミノ酸配列において、１若しくは
数個のアミノ酸が欠失、置換若しくは付加されたアミノ
酸配列からなるＧＰＣＲ蛋白質や、これらの組換え蛋白
質を具体的に挙げることができる。また、本発明の対象
となる上記ＧＰＣＲ蛋白質の部分ペプチドとしては、上
記ＧＰＣＲ蛋白質の一部からなり、かつ各種Ｇ蛋白質を
認識するアミノ酸配列又は各種Ｇ蛋白質と特異的に結合
するアミノ酸配列を有するものであれば特に制限される
ものではない。上記本発明の対象となるＧＰＣＲ蛋白質
及びＧＰＣＲ蛋白質の部分ペプチド、並びにこれら蛋白
質及びペプチドに特異的に結合する抗体が特異的に結合
する組換え蛋白質及びペプチドを総称して、以下「本件
蛋白質・ペプチド」ということがある。なお、本件蛋白
質・ペプチドはそのＤＮＡ配列情報等に基づき公知の方
法で調製することができ、その由来は特に制限されるも
のではない。
【００１７】本発明の融合蛋白質や融合ペプチドとして
は、本件蛋白質・ペプチドとマーカー蛋白質及び／又は
ペプチドタグとが結合しているものであればどのような
ものでもよく、マーカー蛋白質としては、従来知られて
いるマーカー蛋白質であればどのようなものでもよく、
例えば、アルカリフォスファターゼ、抗体のＦｃ領域、
ＨＲＰ、ＧＦＰなどを具体的に挙げることができ、また
本発明におけるペプチドタグとしては、Ｍｙｃタグ、Ｈ
ｉｓタグ、ＦＬＡＧタグ、ＧＳＴタグなどの従来知られ
ているペプチドタグを具体的に例示することができる。
かかる融合蛋白質は、常法により作製することができ、
Ｎｉ−ＮＴＡとＨｉｓタグの親和性を利用したＧＰＣＲ
蛋白質の精製や、ＧＰＣＲ蛋白質の検出や、ＧＰＣＲ蛋
白質に対する抗体の定量や、その他当該分野の研究用試
薬としても有用である。
は、本件蛋白質・ペプチドとマーカー蛋白質及び／又は
ペプチドタグとが結合しているものであればどのような
ものでもよく、マーカー蛋白質としては、従来知られて
いるマーカー蛋白質であればどのようなものでもよく、
例えば、アルカリフォスファターゼ、抗体のＦｃ領域、
ＨＲＰ、ＧＦＰなどを具体的に挙げることができ、また
本発明におけるペプチドタグとしては、Ｍｙｃタグ、Ｈ
ｉｓタグ、ＦＬＡＧタグ、ＧＳＴタグなどの従来知られ
ているペプチドタグを具体的に例示することができる。
かかる融合蛋白質は、常法により作製することができ、
Ｎｉ−ＮＴＡとＨｉｓタグの親和性を利用したＧＰＣＲ
蛋白質の精製や、ＧＰＣＲ蛋白質の検出や、ＧＰＣＲ蛋
白質に対する抗体の定量や、その他当該分野の研究用試
薬としても有用である。
【００１８】本発明の本件蛋白質やペプチドに特異的に
結合する抗体としては、モノクローナル抗体、ポリクロ
ーナル抗体、キメラ抗体、一本鎖抗体、ヒト化抗体等の
免疫特異的な抗体を具体的に挙げることができ、これら
は上記ＧＰＣＲ蛋白質等の蛋白質又はその一部を抗原と
して用いて常法により作製することができるが、その中
でもモノクローナル抗体がその特異性の点でより好まし
い。かかるモノクローナル抗体等のＧＰＣＲ蛋白質に特
異的に結合する抗体は、例えば、ＧＰＣＲ蛋白質の変異
又は欠失に起因する疾病の診断やＧＰＣＲ蛋白質の分子
機構を明らかにする上で有用である。
結合する抗体としては、モノクローナル抗体、ポリクロ
ーナル抗体、キメラ抗体、一本鎖抗体、ヒト化抗体等の
免疫特異的な抗体を具体的に挙げることができ、これら
は上記ＧＰＣＲ蛋白質等の蛋白質又はその一部を抗原と
して用いて常法により作製することができるが、その中
でもモノクローナル抗体がその特異性の点でより好まし
い。かかるモノクローナル抗体等のＧＰＣＲ蛋白質に特
異的に結合する抗体は、例えば、ＧＰＣＲ蛋白質の変異
又は欠失に起因する疾病の診断やＧＰＣＲ蛋白質の分子
機構を明らかにする上で有用である。
【００１９】また、本発明の抗体は、慣用のプロトコー
ルを用いて、動物（好ましくはヒト以外）に本件蛋白質
・ペプチド若しくはエピトープを含む断片、又は該蛋白
質・ペプチドを膜表面に発現した細胞を投与することに
より産生され、例えばモノクローナル抗体の調製には、
連続細胞系の培養物により産生される抗体をもたらす、
ハイブリドーマ法（Nature 256, 495-497, 1975）、ト
リオーマ法、ヒトＢ細胞ハイブリドーマ法（Immunology
Today 4, 72, 1983）及びＥＢＶ−ハイブリドーマ法
（MONOCLONAL ANTIBODIES AND CANCER THERAPY, pp.77-
96, Alan R.Liss,Inc., 1985）など任意の方法を用いる
ことができる。以下に本件蛋白質・ペプチドとして、マ
ウス由来のＧＰＣＲ蛋白質を例に挙げてマウス由来のＧ
ＰＣＲ蛋白質に対して特異的に結合するモノクローナル
抗体、すなわち抗ｍＧＰＣＲ（マウスＧＰＣＲ）モノク
ローナル抗体の作製方法を説明する。
ルを用いて、動物（好ましくはヒト以外）に本件蛋白質
・ペプチド若しくはエピトープを含む断片、又は該蛋白
質・ペプチドを膜表面に発現した細胞を投与することに
より産生され、例えばモノクローナル抗体の調製には、
連続細胞系の培養物により産生される抗体をもたらす、
ハイブリドーマ法（Nature 256, 495-497, 1975）、ト
リオーマ法、ヒトＢ細胞ハイブリドーマ法（Immunology
Today 4, 72, 1983）及びＥＢＶ−ハイブリドーマ法
（MONOCLONAL ANTIBODIES AND CANCER THERAPY, pp.77-
96, Alan R.Liss,Inc., 1985）など任意の方法を用いる
ことができる。以下に本件蛋白質・ペプチドとして、マ
ウス由来のＧＰＣＲ蛋白質を例に挙げてマウス由来のＧ
ＰＣＲ蛋白質に対して特異的に結合するモノクローナル
抗体、すなわち抗ｍＧＰＣＲ（マウスＧＰＣＲ）モノク
ローナル抗体の作製方法を説明する。
【００２０】上記抗ｍＧＰＣＲモノクローナル抗体は、
抗ｍＧＰＣＲモノクローナル抗体産生ハイブリドーマを
インビボ又はインビトロで常法により培養することによ
り生産することができる。例えば、インビボ系において
は、齧歯動物、好ましくはマウス又はラットの腹腔内で
培養することにより、またインビトロ系においては、動
物細胞培養用培地で培養することにより得ることができ
る。インビトロ系でハイブリドーマを培養するための培
地としては、ストレプトマイシンやペニシリン等の抗生
物質を含むＲＰＭＩ１６４０又はＭＥＭ等の細胞培養培
地を例示することができる。
抗ｍＧＰＣＲモノクローナル抗体産生ハイブリドーマを
インビボ又はインビトロで常法により培養することによ
り生産することができる。例えば、インビボ系において
は、齧歯動物、好ましくはマウス又はラットの腹腔内で
培養することにより、またインビトロ系においては、動
物細胞培養用培地で培養することにより得ることができ
る。インビトロ系でハイブリドーマを培養するための培
地としては、ストレプトマイシンやペニシリン等の抗生
物質を含むＲＰＭＩ１６４０又はＭＥＭ等の細胞培養培
地を例示することができる。
【００２１】抗ｍＧＰＣＲモノクローナル抗体産生ハイ
ブリドーマは、例えば、マウス等から得られたＧＰＣＲ
を用いてＢＡＬＢ／ｃマウスを免疫し、免疫されたマウ
スの脾臓細胞とマウスＮＳ−１細胞（ＡＴＣＣ ＴＩＢ
−１８）とを、常法により細胞融合させ、免疫蛍光染色
パターンによりスクリーニングすることにより、抗ｍＧ
ＰＣＲモノクローナル抗体産生ハイブリドーマを作出す
ることができる。また、かかるモノクローナル抗体の分
離・精製方法としては、蛋白質の精製に一般的に用いら
れる方法であればどのような方法でもよく、アフィニテ
ィークロマトグラフィー等の液体クロマトグラフィーを
具体的に例示することができる。
ブリドーマは、例えば、マウス等から得られたＧＰＣＲ
を用いてＢＡＬＢ／ｃマウスを免疫し、免疫されたマウ
スの脾臓細胞とマウスＮＳ−１細胞（ＡＴＣＣ ＴＩＢ
−１８）とを、常法により細胞融合させ、免疫蛍光染色
パターンによりスクリーニングすることにより、抗ｍＧ
ＰＣＲモノクローナル抗体産生ハイブリドーマを作出す
ることができる。また、かかるモノクローナル抗体の分
離・精製方法としては、蛋白質の精製に一般的に用いら
れる方法であればどのような方法でもよく、アフィニテ
ィークロマトグラフィー等の液体クロマトグラフィーを
具体的に例示することができる。
【００２２】また、本発明の上記本件蛋白質・ペプチド
に対する一本鎖抗体をつくるためには、一本鎖抗体の調
製法（米国特許第4,946,778号）を適用することができ
る。また、ヒト化抗体を発現させるために、トランスジ
ェニックマウス又は他の哺乳動物等を利用したり、上記
抗体を用いて、本件蛋白質・ペプチドを発現するクロー
ンを単離・同定したり、アフィニティークロマトグラフ
ィーでそのポリペプチドを精製することもできる。本件
蛋白質・ペプチドやその抗原エピトープを含むペプチド
に対する抗体は、ＧＰＣＲ蛋白質の分子機構を明らかに
する上で有用である。そして、これら抗体が特異的に結
合する組換え蛋白質又はペプチドも、前記のように本発
明の本件蛋白質・ペプチドに包含される。
に対する一本鎖抗体をつくるためには、一本鎖抗体の調
製法（米国特許第4,946,778号）を適用することができ
る。また、ヒト化抗体を発現させるために、トランスジ
ェニックマウス又は他の哺乳動物等を利用したり、上記
抗体を用いて、本件蛋白質・ペプチドを発現するクロー
ンを単離・同定したり、アフィニティークロマトグラフ
ィーでそのポリペプチドを精製することもできる。本件
蛋白質・ペプチドやその抗原エピトープを含むペプチド
に対する抗体は、ＧＰＣＲ蛋白質の分子機構を明らかに
する上で有用である。そして、これら抗体が特異的に結
合する組換え蛋白質又はペプチドも、前記のように本発
明の本件蛋白質・ペプチドに包含される。
【００２３】また上記抗ｍＧＰＣＲモノクローナル抗体
等の抗体に、例えば、ＦＩＴＣ（フルオレセインイソシ
アネート）又はテトラメチルローダミンイソシアネート
等の蛍光物質や、125Ｉ、32Ｐ、14Ｃ、35Ｓ又は3Ｈ等の
ラジオアイソトープや、アルカリホスファターゼ、ペル
オキシダーゼ、β−ガラクトシダーゼ又はフィコエリト
リン等の酵素で標識したものや、グリーン蛍光蛋白質
（ＧＦＰ）等の蛍光発光蛋白質などを融合させた融合蛋
白質を用いることによって、本件蛋白質・ペプチドの機
能解析を行うことができる。また免疫学的測定方法とし
ては、ＲＩＡ法、ＥＬＩＳＡ法、蛍光抗体法、プラーク
法、スポット法、血球凝集反応法、オクタロニー法等の
方法を挙げることができる。
等の抗体に、例えば、ＦＩＴＣ（フルオレセインイソシ
アネート）又はテトラメチルローダミンイソシアネート
等の蛍光物質や、125Ｉ、32Ｐ、14Ｃ、35Ｓ又は3Ｈ等の
ラジオアイソトープや、アルカリホスファターゼ、ペル
オキシダーゼ、β−ガラクトシダーゼ又はフィコエリト
リン等の酵素で標識したものや、グリーン蛍光蛋白質
（ＧＦＰ）等の蛍光発光蛋白質などを融合させた融合蛋
白質を用いることによって、本件蛋白質・ペプチドの機
能解析を行うことができる。また免疫学的測定方法とし
ては、ＲＩＡ法、ＥＬＩＳＡ法、蛍光抗体法、プラーク
法、スポット法、血球凝集反応法、オクタロニー法等の
方法を挙げることができる。
【００２４】本発明はまた、本件蛋白質・ペプチドを発
現することができる発現系を含んでなる宿主細胞に関す
る。かかる本件蛋白質・ペプチドをコードする遺伝子の
宿主細胞への導入は、Davisら（BASIC METHODS IN MOLE
CULAR BIOLOGY, 1986）及びSambrookら（MOLECULAR CLO
NING: A LABORATORY MANUAL, 2nd Ed., Cold SpringHar
bor Laboratory Press, Cold Spring Harbor, N.Y., 19
89）などの多くの標準的な実験室マニュアルに記載され
る方法、例えば、リン酸カルシウムトランスフェクショ
ン、ＤＥＡＥ−デキストラン媒介トランスフェクショ
ン、トランスベクション(transvection)、マイクロイン
ジェクション、カチオン性脂質媒介トランスフェクショ
ン、エレクトロポレーション、形質導入、スクレープロ
ーディング (scrape loading)、弾丸導入(ballistic in
troduction)、感染等により行うことができる。そし
て、宿主細胞としては、大腸菌、ストレプトミセス、枯
草菌、ストレプトコッカス、スタフィロコッカス等の細
菌原核細胞や、酵母、アスペルギルス等の真菌細胞や、
ドロソフィラＳ２、スポドプテラＳｆ９等の昆虫細胞
や、Ｌ細胞、ＣＨＯ細胞、ＣＯＳ細胞、ＨｅＬａ細胞、
Ｃ１２７細胞、ＢＡＬＢ／ｃ３Ｔ３細胞（ジヒドロ葉酸
レダクターゼやチミジンキナーゼなどを欠損した変異株
を含む）、ＢＨＫ２１細胞、ＨＥＫ２９３細胞、Ｂｏｗ
ｅｓメラノーマ細胞、卵母細胞等の動植物細胞などを挙
げることができる。
現することができる発現系を含んでなる宿主細胞に関す
る。かかる本件蛋白質・ペプチドをコードする遺伝子の
宿主細胞への導入は、Davisら（BASIC METHODS IN MOLE
CULAR BIOLOGY, 1986）及びSambrookら（MOLECULAR CLO
NING: A LABORATORY MANUAL, 2nd Ed., Cold SpringHar
bor Laboratory Press, Cold Spring Harbor, N.Y., 19
89）などの多くの標準的な実験室マニュアルに記載され
る方法、例えば、リン酸カルシウムトランスフェクショ
ン、ＤＥＡＥ−デキストラン媒介トランスフェクショ
ン、トランスベクション(transvection)、マイクロイン
ジェクション、カチオン性脂質媒介トランスフェクショ
ン、エレクトロポレーション、形質導入、スクレープロ
ーディング (scrape loading)、弾丸導入(ballistic in
troduction)、感染等により行うことができる。そし
て、宿主細胞としては、大腸菌、ストレプトミセス、枯
草菌、ストレプトコッカス、スタフィロコッカス等の細
菌原核細胞や、酵母、アスペルギルス等の真菌細胞や、
ドロソフィラＳ２、スポドプテラＳｆ９等の昆虫細胞
や、Ｌ細胞、ＣＨＯ細胞、ＣＯＳ細胞、ＨｅＬａ細胞、
Ｃ１２７細胞、ＢＡＬＢ／ｃ３Ｔ３細胞（ジヒドロ葉酸
レダクターゼやチミジンキナーゼなどを欠損した変異株
を含む）、ＢＨＫ２１細胞、ＨＥＫ２９３細胞、Ｂｏｗ
ｅｓメラノーマ細胞、卵母細胞等の動植物細胞などを挙
げることができる。
【００２５】また、発現系としては、本件蛋白質・ペプ
チドを宿主細胞内で発現させることができる発現系であ
ればどのようなものでもよく、染色体、エピソーム及び
ウイルスに由来する発現系、例えば、細菌プラスミド由
来、酵母プラスミド由来、ＳＶ４０のようなパポバウイ
ルス、ワクシニアウイルス、アデノウイルス、鶏痘ウイ
ルス、仮性狂犬病ウイルス、レトロウイルス由来のベク
ター、バクテリオファージ由来、トランスポゾン由来及
びこれらの組合せに由来するベクター、例えば、コスミ
ドやファージミドのようなプラスミドとバクテリオファ
ージの遺伝的要素に由来するものを挙げることができ
る。これら発現系は、発現を起こさせるだけでなく、発
現を調節する制御配列を含んでいてもよい。
チドを宿主細胞内で発現させることができる発現系であ
ればどのようなものでもよく、染色体、エピソーム及び
ウイルスに由来する発現系、例えば、細菌プラスミド由
来、酵母プラスミド由来、ＳＶ４０のようなパポバウイ
ルス、ワクシニアウイルス、アデノウイルス、鶏痘ウイ
ルス、仮性狂犬病ウイルス、レトロウイルス由来のベク
ター、バクテリオファージ由来、トランスポゾン由来及
びこれらの組合せに由来するベクター、例えば、コスミ
ドやファージミドのようなプラスミドとバクテリオファ
ージの遺伝的要素に由来するものを挙げることができ
る。これら発現系は、発現を起こさせるだけでなく、発
現を調節する制御配列を含んでいてもよい。
【００２６】上記発現系を含んでなる宿主細胞やかかる
細胞の細胞膜、またかかる細胞を培養して得られる本件
蛋白質・ペプチドは、後述するように本発明のスクリー
ニング方法に用いることができる。例えば、細胞膜を得
る方法としては、F. Pietri-Rouxel（Eur. J. Bioche
m., 247, 1174-1179, 1997）らの方法などを用いること
ができ、また、かかる本件蛋白質・ペプチドを細胞培養
物から回収し精製するには、硫酸アンモニウムまたはエ
タノール沈殿、酸抽出、アニオンまたはカチオン交換ク
ロマトグラフィー、ホスホセルロースクロマトグラフィ
ー、疎水性相互作用クロマトグラフィー、アフィニティ
ークロマトグラフィー、ハイドロキシアパタイトクロマ
トグラフィーおよびレクチンクロマトグラフィーを含め
た公知の方法、好ましくは、高速液体クロマトグラフィ
ーが用いられる。特に、アフィニティークロマトグラフ
ィーに用いるカラムとしては、例えば、抗ＧＰＣＲモノ
クローナル抗体等の本件蛋白質・ペプチドに対する抗体
を結合させたカラムや、上記本件蛋白質・ペプチドに通
常のペプチドタグを付加した場合は、このペプチドタグ
に親和性のある物質を結合したカラムを用いることによ
り、本件蛋白質・ペプチドを得ることができる。上記本
件蛋白質・ペプチドの精製方法は、ペプチド合成の際に
も適用することができる。
細胞の細胞膜、またかかる細胞を培養して得られる本件
蛋白質・ペプチドは、後述するように本発明のスクリー
ニング方法に用いることができる。例えば、細胞膜を得
る方法としては、F. Pietri-Rouxel（Eur. J. Bioche
m., 247, 1174-1179, 1997）らの方法などを用いること
ができ、また、かかる本件蛋白質・ペプチドを細胞培養
物から回収し精製するには、硫酸アンモニウムまたはエ
タノール沈殿、酸抽出、アニオンまたはカチオン交換ク
ロマトグラフィー、ホスホセルロースクロマトグラフィ
ー、疎水性相互作用クロマトグラフィー、アフィニティ
ークロマトグラフィー、ハイドロキシアパタイトクロマ
トグラフィーおよびレクチンクロマトグラフィーを含め
た公知の方法、好ましくは、高速液体クロマトグラフィ
ーが用いられる。特に、アフィニティークロマトグラフ
ィーに用いるカラムとしては、例えば、抗ＧＰＣＲモノ
クローナル抗体等の本件蛋白質・ペプチドに対する抗体
を結合させたカラムや、上記本件蛋白質・ペプチドに通
常のペプチドタグを付加した場合は、このペプチドタグ
に親和性のある物質を結合したカラムを用いることによ
り、本件蛋白質・ペプチドを得ることができる。上記本
件蛋白質・ペプチドの精製方法は、ペプチド合成の際に
も適用することができる。
【００２７】本発明において、上記本件蛋白質・ペプチ
ドを過剰発現する非ヒト動物とは、野生型非ヒト動物に
比べてかかる本件蛋白質・ペプチドを大量に産生する非
ヒト動物をいい、また、本件蛋白質・ペプチドをコード
する遺伝子機能が染色体上で欠損した非ヒト動物とは、
染色体上の本件蛋白質・ペプチドをコードする遺伝子の
一部若しくは全部が破壊・欠損・置換等の遺伝子変異に
より不活性化され、本件蛋白質・ペプチドを発現する機
能を失なった非ヒト動物をいう。そして、本発明におけ
る非ヒト動物としては、ウサギや、マウス、ラット等の
齧歯目動物などの非ヒト動物を具体的に挙げることがで
きるが、これらに限定されるものではない。
ドを過剰発現する非ヒト動物とは、野生型非ヒト動物に
比べてかかる本件蛋白質・ペプチドを大量に産生する非
ヒト動物をいい、また、本件蛋白質・ペプチドをコード
する遺伝子機能が染色体上で欠損した非ヒト動物とは、
染色体上の本件蛋白質・ペプチドをコードする遺伝子の
一部若しくは全部が破壊・欠損・置換等の遺伝子変異に
より不活性化され、本件蛋白質・ペプチドを発現する機
能を失なった非ヒト動物をいう。そして、本発明におけ
る非ヒト動物としては、ウサギや、マウス、ラット等の
齧歯目動物などの非ヒト動物を具体的に挙げることがで
きるが、これらに限定されるものではない。
【００２８】ところで、メンデルの法則に従い出生して
くるホモ接合体非ヒト動物には、本件蛋白質・ペプチド
欠損型又は過剰発現型とその同腹の野生型とが含まれ、
これらホモ接合体非ヒト動物における欠損型又は過剰発
現型とその同腹の野生型を同時に用いることによって個
体レベルで正確な比較実験をすることができることか
ら、野生型の非ヒト動物、すなわち本件蛋白質・ペプチ
ドをコードする遺伝子機能が染色体上で欠損又は過剰発
現する非ヒト動物と同種の動物、さらには同腹の動物
を、例えば下記に記載する本発明のスクリーニングに際
して併用することが好ましい。かかる本件蛋白質・ペプ
チドをコードする遺伝子機能が染色体上で欠損又は過剰
発現する非ヒト動物の作製方法を、ＧＰＣＲ蛋白質のノ
ックアウトマウスやトランスジェニックマウスを例にと
って以下説明する。
くるホモ接合体非ヒト動物には、本件蛋白質・ペプチド
欠損型又は過剰発現型とその同腹の野生型とが含まれ、
これらホモ接合体非ヒト動物における欠損型又は過剰発
現型とその同腹の野生型を同時に用いることによって個
体レベルで正確な比較実験をすることができることか
ら、野生型の非ヒト動物、すなわち本件蛋白質・ペプチ
ドをコードする遺伝子機能が染色体上で欠損又は過剰発
現する非ヒト動物と同種の動物、さらには同腹の動物
を、例えば下記に記載する本発明のスクリーニングに際
して併用することが好ましい。かかる本件蛋白質・ペプ
チドをコードする遺伝子機能が染色体上で欠損又は過剰
発現する非ヒト動物の作製方法を、ＧＰＣＲ蛋白質のノ
ックアウトマウスやトランスジェニックマウスを例にと
って以下説明する。
【００２９】例えば、ＧＰＣＲ蛋白質をコードする遺伝
子機能が染色体上で欠損したマウス、すなわちＧＰＣＲ
蛋白質ノックアウトマウスは、マウス遺伝子ライブラリ
ーからＰＣＲ等の方法により得られた遺伝子断片を用い
て、上記ＧＰＣＲ蛋白質をコードする遺伝子をスクリー
ニングし、スクリーニングされたＧＰＣＲ蛋白質をコー
ドする遺伝子をウイルスベクター等を用いてサブクロー
ンし、ＤＮＡシーケンシングにより特定する。このクロ
ーンのＧＰＣＲ蛋白質をコードする遺伝子の全部又は一
部をｐＭＣ１ネオ遺伝子カセット等に置換し、３′末端
側にジフテリアトキシンＡフラグメント（ＤＴ−Ａ）遺
伝子や単純ヘルペスウイルスのチミジンキナーゼ（ＨＳ
Ｖ−ｔｋ）遺伝子等の遺伝子を導入することによって、
ターゲットベクターを作製する。
子機能が染色体上で欠損したマウス、すなわちＧＰＣＲ
蛋白質ノックアウトマウスは、マウス遺伝子ライブラリ
ーからＰＣＲ等の方法により得られた遺伝子断片を用い
て、上記ＧＰＣＲ蛋白質をコードする遺伝子をスクリー
ニングし、スクリーニングされたＧＰＣＲ蛋白質をコー
ドする遺伝子をウイルスベクター等を用いてサブクロー
ンし、ＤＮＡシーケンシングにより特定する。このクロ
ーンのＧＰＣＲ蛋白質をコードする遺伝子の全部又は一
部をｐＭＣ１ネオ遺伝子カセット等に置換し、３′末端
側にジフテリアトキシンＡフラグメント（ＤＴ−Ａ）遺
伝子や単純ヘルペスウイルスのチミジンキナーゼ（ＨＳ
Ｖ−ｔｋ）遺伝子等の遺伝子を導入することによって、
ターゲットベクターを作製する。
【００３０】この作製されたターゲティングベクターを
線状化し、エレクトロポレーション（電気穿孔）法等に
よってＥＳ細胞に導入し、相同的組換えを行い、その相
同的組換え体の中から、Ｇ４１８やガンシクロビア（Ｇ
ＡＮＣ）等の抗生物質により相同的組換えを起こしたＥ
Ｓ細胞を選択する。また、この選択されたＥＳ細胞が目
的とする組換え体かどうかをサザンブロット法等により
確認することが好ましい。その確認されたＥＳ細胞のク
ローンをマウスの胚盤胞中にマイクロインジェクション
し、かかる胚盤胞を仮親のマウスに戻し、キメラマウス
を作製する。このキメラマウスを野生型のマウスとイン
タークロスさせると、ヘテロ接合体マウスを得ることが
でき、また、このヘテロ接合体マウスをインタークロス
させることによって、本発明のＧＰＣＲ蛋白質ノックア
ウトマウスを作製することができる。また、ＧＰＣＲ蛋
白質ノックアウトマウスが生起しているかどうかを確認
する方法としては、例えば、上記の方法により得られた
マウスからＲＮＡを単離してノーザンブロット法等によ
り調べたり、またこのマウスの発現をウエスタンブロッ
ト法等により調べる方法がある。
線状化し、エレクトロポレーション（電気穿孔）法等に
よってＥＳ細胞に導入し、相同的組換えを行い、その相
同的組換え体の中から、Ｇ４１８やガンシクロビア（Ｇ
ＡＮＣ）等の抗生物質により相同的組換えを起こしたＥ
Ｓ細胞を選択する。また、この選択されたＥＳ細胞が目
的とする組換え体かどうかをサザンブロット法等により
確認することが好ましい。その確認されたＥＳ細胞のク
ローンをマウスの胚盤胞中にマイクロインジェクション
し、かかる胚盤胞を仮親のマウスに戻し、キメラマウス
を作製する。このキメラマウスを野生型のマウスとイン
タークロスさせると、ヘテロ接合体マウスを得ることが
でき、また、このヘテロ接合体マウスをインタークロス
させることによって、本発明のＧＰＣＲ蛋白質ノックア
ウトマウスを作製することができる。また、ＧＰＣＲ蛋
白質ノックアウトマウスが生起しているかどうかを確認
する方法としては、例えば、上記の方法により得られた
マウスからＲＮＡを単離してノーザンブロット法等によ
り調べたり、またこのマウスの発現をウエスタンブロッ
ト法等により調べる方法がある。
【００３１】ＧＰＣＲ蛋白質のトランスジェニックマウ
スは、ＧＰＣＲ蛋白質をコードするｃＤＮＡにチキンβ
−アクチン、マウスニューロフィラメント、ＳＶ４０等
のプロモーター、及びラビットβ−グロビン、ＳＶ４０
等のポリＡ又はイントロンを融合させて導入遺伝子を構
築し、該導入遺伝子をマウス受精卵の前核にマイクロイ
ンジェクションし、得られた卵細胞を培養した後、仮親
のマウスの輸卵管に移植し、その後被移植動物を飼育
し、産まれた仔マウスから前記ｃＤＮＡを有する仔マウ
スを選択することによりかかるトランスジェニックマウ
スを創製することができる。また、ｃＤＮＡを有する仔
マウスの選択は、マウスの尻尾等より粗ＤＮＡを抽出
し、導入したＧＰＣＲ蛋白質をコードする遺伝子をプロ
ーブとするドットハイブリダイゼーション法や、特異的
プライマーを用いたＰＣＲ法等により行うことができ
る。
スは、ＧＰＣＲ蛋白質をコードするｃＤＮＡにチキンβ
−アクチン、マウスニューロフィラメント、ＳＶ４０等
のプロモーター、及びラビットβ−グロビン、ＳＶ４０
等のポリＡ又はイントロンを融合させて導入遺伝子を構
築し、該導入遺伝子をマウス受精卵の前核にマイクロイ
ンジェクションし、得られた卵細胞を培養した後、仮親
のマウスの輸卵管に移植し、その後被移植動物を飼育
し、産まれた仔マウスから前記ｃＤＮＡを有する仔マウ
スを選択することによりかかるトランスジェニックマウ
スを創製することができる。また、ｃＤＮＡを有する仔
マウスの選択は、マウスの尻尾等より粗ＤＮＡを抽出
し、導入したＧＰＣＲ蛋白質をコードする遺伝子をプロ
ーブとするドットハイブリダイゼーション法や、特異的
プライマーを用いたＰＣＲ法等により行うことができ
る。
【００３２】本発明のＧＰＣＲ等の本件蛋白質・ペプチ
ドの機能促進又は抑制物質のスクリーニング方法として
は、前記本件蛋白質・ペプチド又は本件蛋白質・ペプチ
ドを発現している細胞膜と、被検物質とを用いる方法
や、前記本件蛋白質・ペプチド又は本件蛋白質・ペプチ
ドを発現している細胞膜と、Ｇ蛋白質と、被検物質とを
用いる方法や、本件蛋白質・ペプチドを発現している細
胞と、被検物質とを用いる方法や、本件蛋白質・ペプチ
ドのノックアウトマウスやトランスジェニックマウス等
の非ヒト動物と、被検物質とを用いる方法等を挙げるこ
とができる。
ドの機能促進又は抑制物質のスクリーニング方法として
は、前記本件蛋白質・ペプチド又は本件蛋白質・ペプチ
ドを発現している細胞膜と、被検物質とを用いる方法
や、前記本件蛋白質・ペプチド又は本件蛋白質・ペプチ
ドを発現している細胞膜と、Ｇ蛋白質と、被検物質とを
用いる方法や、本件蛋白質・ペプチドを発現している細
胞と、被検物質とを用いる方法や、本件蛋白質・ペプチ
ドのノックアウトマウスやトランスジェニックマウス等
の非ヒト動物と、被検物質とを用いる方法等を挙げるこ
とができる。
【００３３】上記本件蛋白質・ペプチド又は本件蛋白質
・ペプチドを発現している細胞膜と被検物質とを用いる
スクリーニング方法としては、本件蛋白質・ペプチド又
は細胞膜表面に発現している本件蛋白質・ペプチドと被
検物質とを接触せしめ、本件蛋白質・ペプチド又は細胞
膜表面に発現している本件蛋白質・ペプチドと、被検物
質との結合状態を測定評価する方法を挙げることができ
る。また、上記本件蛋白質・ペプチド又は本件蛋白質・
ペプチドを発現している細胞膜と、Ｇ蛋白質と、被検物
質とを用いる方法としては、本件蛋白質・ペプチド又は
細胞膜表面に発現している本件蛋白質・ペプチドとＧ蛋
白質と被検物質とを接触せしめ、本件蛋白質・ペプチド
又は細胞膜表面に発現している本件蛋白質・ペプチド
と、Ｇ蛋白質との相互作用を測定評価する方法を挙げる
ことができる。
・ペプチドを発現している細胞膜と被検物質とを用いる
スクリーニング方法としては、本件蛋白質・ペプチド又
は細胞膜表面に発現している本件蛋白質・ペプチドと被
検物質とを接触せしめ、本件蛋白質・ペプチド又は細胞
膜表面に発現している本件蛋白質・ペプチドと、被検物
質との結合状態を測定評価する方法を挙げることができ
る。また、上記本件蛋白質・ペプチド又は本件蛋白質・
ペプチドを発現している細胞膜と、Ｇ蛋白質と、被検物
質とを用いる方法としては、本件蛋白質・ペプチド又は
細胞膜表面に発現している本件蛋白質・ペプチドとＧ蛋
白質と被検物質とを接触せしめ、本件蛋白質・ペプチド
又は細胞膜表面に発現している本件蛋白質・ペプチド
と、Ｇ蛋白質との相互作用を測定評価する方法を挙げる
ことができる。
【００３４】上記本件蛋白質・ペプチドのノックアウト
マウスやトランスジェニックマウス等の非ヒト動物と、
被検物質とを用いる方法としては、かかる非ヒト動物か
ら得られる本件蛋白質・ペプチド発現細胞と被検物質と
をあらかじめインビトロで接触せしめた後、かかる本件
蛋白質・ペプチド発現細胞をＧ蛋白質の存在下で培養
し、該本件蛋白質・ペプチド発現細胞におけるＧ蛋白質
に対する応答を測定・評価する方法や、前記非ヒト動物
から得られる本件蛋白質・ペプチド発現細胞とＧ蛋白質
とをあらかじめインビトロで接触せしめた後、該本件蛋
白質・ペプチド発現細胞を被検物質の存在下で培養し、
該本件蛋白質・ペプチド発現細胞におけるＧ蛋白質との
結合状態等のＧ蛋白質に対する応答を測定・評価する方
法や、前記非ヒト動物にあらかじめ被検物質を投与した
後、該非ヒト動物から得られる本件蛋白質・ペプチド発
現細胞をＧ蛋白質の存在下で培養し、該本件蛋白質・ペ
プチド発現細胞におけるＧ蛋白質に対する応答を測定・
評価する方法を挙げることができる。
マウスやトランスジェニックマウス等の非ヒト動物と、
被検物質とを用いる方法としては、かかる非ヒト動物か
ら得られる本件蛋白質・ペプチド発現細胞と被検物質と
をあらかじめインビトロで接触せしめた後、かかる本件
蛋白質・ペプチド発現細胞をＧ蛋白質の存在下で培養
し、該本件蛋白質・ペプチド発現細胞におけるＧ蛋白質
に対する応答を測定・評価する方法や、前記非ヒト動物
から得られる本件蛋白質・ペプチド発現細胞とＧ蛋白質
とをあらかじめインビトロで接触せしめた後、該本件蛋
白質・ペプチド発現細胞を被検物質の存在下で培養し、
該本件蛋白質・ペプチド発現細胞におけるＧ蛋白質との
結合状態等のＧ蛋白質に対する応答を測定・評価する方
法や、前記非ヒト動物にあらかじめ被検物質を投与した
後、該非ヒト動物から得られる本件蛋白質・ペプチド発
現細胞をＧ蛋白質の存在下で培養し、該本件蛋白質・ペ
プチド発現細胞におけるＧ蛋白質に対する応答を測定・
評価する方法を挙げることができる。
【００３５】本件蛋白質・ペプチドの機能促進若しくは
抑制物質又は本件蛋白質・ペプチドの発現促進又は抑制
物質、例えばＧＰＣＲのリガンド等は、上記スクリーニ
ング方法により得ることができる。また、本発明の医薬
組成物は、有効成分として前記本件蛋白質・ペプチドの
他、本件蛋白質・ペプチドの機能促進若しくは抑制物質
又は本件蛋白質・ペプチドの発現促進若しくは抑制物質
を含んでいるものであれば特に制限されるものではな
く、これら医薬組成物は、本件蛋白質・ペプチドの機能
促進又は発現増強を必要としている患者や、本件蛋白質
・ペプチドの機能又は発現の抑制を必要としている患者
を治療するのに用いることができる。さらに、本件蛋白
質・ペプチドの機能又は発現に関連する疾病の診断方法
としては、検体中における本発明のＧＰＣＲ蛋白質をコ
ードするＤＮＡ配列を前記本発明のＧＰＣＲ蛋白質をコ
ードするＤＮＡ配列と比較する方法であれば特に制限さ
れるものではなく、また、本件蛋白質・ペプチドの機能
又は発現に関連する疾病の診断用プローブとしては、前
記本発明のＧＰＣＲ蛋白質をコードするＤＮＡ又はＲＮ
Ａのアンチセンス鎖の全部又は一部からなるものであれ
ば特に制限されるものではなく、本件蛋白質・ペプチド
の機能又は発現に関連する疾病の診断薬としては、上記
診断用プローブや前記抗体を含有するものであれば特に
制限されるものではない。
抑制物質又は本件蛋白質・ペプチドの発現促進又は抑制
物質、例えばＧＰＣＲのリガンド等は、上記スクリーニ
ング方法により得ることができる。また、本発明の医薬
組成物は、有効成分として前記本件蛋白質・ペプチドの
他、本件蛋白質・ペプチドの機能促進若しくは抑制物質
又は本件蛋白質・ペプチドの発現促進若しくは抑制物質
を含んでいるものであれば特に制限されるものではな
く、これら医薬組成物は、本件蛋白質・ペプチドの機能
促進又は発現増強を必要としている患者や、本件蛋白質
・ペプチドの機能又は発現の抑制を必要としている患者
を治療するのに用いることができる。さらに、本件蛋白
質・ペプチドの機能又は発現に関連する疾病の診断方法
としては、検体中における本発明のＧＰＣＲ蛋白質をコ
ードするＤＮＡ配列を前記本発明のＧＰＣＲ蛋白質をコ
ードするＤＮＡ配列と比較する方法であれば特に制限さ
れるものではなく、また、本件蛋白質・ペプチドの機能
又は発現に関連する疾病の診断用プローブとしては、前
記本発明のＧＰＣＲ蛋白質をコードするＤＮＡ又はＲＮ
Ａのアンチセンス鎖の全部又は一部からなるものであれ
ば特に制限されるものではなく、本件蛋白質・ペプチド
の機能又は発現に関連する疾病の診断薬としては、上記
診断用プローブや前記抗体を含有するものであれば特に
制限されるものではない。
【００３６】
【実施例】以下に、実施例を揚げてこの発明を更に具体
的に説明するが、この発明の範囲はこれらの例示に限定
されるものではない。これまでに報告されている嗅覚、
味覚受容体以外のＧＰＣＲ遺伝子にイントロンを含むか
どうかを調べたところ、９５種類のＧＰＣＲ遺伝子には
イントロンを含まず、６３種類のものはイントロンを含
むことが確認できたことから、ＧＰＣＲ遺伝子の約６０
％にはイントロンがないと期待できる。また、ヒトの嗅
覚、味覚受容体についてはイントロンの存在はこれまで
報告されていない。そこで、イントロンを持たないＧＰ
ＣＲを以下のように検索してみた。
的に説明するが、この発明の範囲はこれらの例示に限定
されるものではない。これまでに報告されている嗅覚、
味覚受容体以外のＧＰＣＲ遺伝子にイントロンを含むか
どうかを調べたところ、９５種類のＧＰＣＲ遺伝子には
イントロンを含まず、６３種類のものはイントロンを含
むことが確認できたことから、ＧＰＣＲ遺伝子の約６０
％にはイントロンがないと期待できる。また、ヒトの嗅
覚、味覚受容体についてはイントロンの存在はこれまで
報告されていない。そこで、イントロンを持たないＧＰ
ＣＲを以下のように検索してみた。
【００３７】［ヒトゲノムデータからの推定ＧＰＣＲ遺
伝子の抽出］ヒトゲノムデータ（２０００年８月１８日
現在のもの）を用いて、ＧＰＣＲ遺伝子の候補となりう
るオープンリーディングフレーム（ＯＲＦ：Open Readi
ng Frame）を抽出し、ＳＯＳＵＩによる分析を行った。
なお、今回用いたヒトゲノムデータには、同一の確定さ
れていない配列を重複して含んでいるため、ヒトゲノム
全体が約３Ｇ塩基対であるのに対してこのデータは約
４．５Ｇ塩基対からなる。ヒトゲノムデータから、２０
０〜１５００のアミノ酸残基をコードするＤＮＡからな
る約２１万個のＯＲＦを抽出し、この中からＤＮＡの繰
り返し配列に由来すると思われるＯＲＦや不確定なアミ
ノ酸が多いＯＲＦや、同じアミノ酸を２０％以上含むＯ
ＲＦを排除することによって約１３万個のＯＲＦを得
た。これら１３万個のＯＲＦをＳＯＳＵＩにより解析す
るに先立って、ＳＯＳＵＩ解析の有効性について検討し
た。
伝子の抽出］ヒトゲノムデータ（２０００年８月１８日
現在のもの）を用いて、ＧＰＣＲ遺伝子の候補となりう
るオープンリーディングフレーム（ＯＲＦ：Open Readi
ng Frame）を抽出し、ＳＯＳＵＩによる分析を行った。
なお、今回用いたヒトゲノムデータには、同一の確定さ
れていない配列を重複して含んでいるため、ヒトゲノム
全体が約３Ｇ塩基対であるのに対してこのデータは約
４．５Ｇ塩基対からなる。ヒトゲノムデータから、２０
０〜１５００のアミノ酸残基をコードするＤＮＡからな
る約２１万個のＯＲＦを抽出し、この中からＤＮＡの繰
り返し配列に由来すると思われるＯＲＦや不確定なアミ
ノ酸が多いＯＲＦや、同じアミノ酸を２０％以上含むＯ
ＲＦを排除することによって約１３万個のＯＲＦを得
た。これら１３万個のＯＲＦをＳＯＳＵＩにより解析す
るに先立って、ＳＯＳＵＩ解析の有効性について検討し
た。
【００３８】［ＳＯＳＵＩ解析の有効性］ＳＯＳＵＩを
用いた解析ではＧＰＣＲのシグナルペプチドが膜貫通領
域として判定される可能性があり、またＧＰＣＲ構造上
で７回目の膜貫通領域は疎水性が低い傾向があるので、
ＳＯＳＵＩで膜貫通領域と判定できない可能性が考えら
れる。そこで、既知のＧＰＣＲのアミノ酸配列をＳＯＳ
ＵＩで解析することにより、ＳＯＳＵＩがどの程度ＧＰ
ＣＲの検索に有効であるかをまず検討した。これまでに
報告されている嗅覚、味覚受容体以外の２０７種類のＧ
ＰＣＲをＳＯＳＵＩで解析したところ、９５％に相当す
る１９７種類のＧＰＣＲにおいて膜貫通領域を６〜８個
含むとの解析結果が得られた。また、４３種類の嗅覚受
容体においても同様の解析を行ったところ、７７％に相
当する３３種類のＧＰＣＲにおいて膜貫通領域を６〜８
個含むとの解析結果が得られた。したがってＳＯＳＵＩ
の予想能力は嗅覚、味覚受容体以外のＧＰＣＲについて
は９５％程度、嗅覚受容体については７７％程度だと考
えられた。上記、これまでに報告されている嗅覚、味覚
受容体以外の２０７種類のＧＰＣＲはウエブサイトhtt
p://www.gpcr.org/7tm/seq/dna.htmlからダウンロード
したものを、嗅覚受容体遺伝子はウエブサイトhttp://y
cmi.med.yale.edu/senselab/ORDBからダウンロードした
ものを用いた。
用いた解析ではＧＰＣＲのシグナルペプチドが膜貫通領
域として判定される可能性があり、またＧＰＣＲ構造上
で７回目の膜貫通領域は疎水性が低い傾向があるので、
ＳＯＳＵＩで膜貫通領域と判定できない可能性が考えら
れる。そこで、既知のＧＰＣＲのアミノ酸配列をＳＯＳ
ＵＩで解析することにより、ＳＯＳＵＩがどの程度ＧＰ
ＣＲの検索に有効であるかをまず検討した。これまでに
報告されている嗅覚、味覚受容体以外の２０７種類のＧ
ＰＣＲをＳＯＳＵＩで解析したところ、９５％に相当す
る１９７種類のＧＰＣＲにおいて膜貫通領域を６〜８個
含むとの解析結果が得られた。また、４３種類の嗅覚受
容体においても同様の解析を行ったところ、７７％に相
当する３３種類のＧＰＣＲにおいて膜貫通領域を６〜８
個含むとの解析結果が得られた。したがってＳＯＳＵＩ
の予想能力は嗅覚、味覚受容体以外のＧＰＣＲについて
は９５％程度、嗅覚受容体については７７％程度だと考
えられた。上記、これまでに報告されている嗅覚、味覚
受容体以外の２０７種類のＧＰＣＲはウエブサイトhtt
p://www.gpcr.org/7tm/seq/dna.htmlからダウンロード
したものを、嗅覚受容体遺伝子はウエブサイトhttp://y
cmi.med.yale.edu/senselab/ORDBからダウンロードした
ものを用いた。
【００３９】［ホモロジー（ＢＬＡＳＴ）検索］上記１
３万個のＯＲＦをＳＯＳＵＩにより分析した結果、膜貫
通領域を６〜８個含むＯＲＦが１１５０個得られた。得
られたＧＰＣＲ候補１１５０個のＯＲＦの配列を、ＢＬ
ＡＳＴを用いて２０００年８月２０日現在のデータベー
ス“ｎｒ”と照会し、既知のＧＰＣＲとの相同性を調べ
てみた結果、既知のＧＰＣＲとホモロジーを持つものが
５２２個得られた。さらにこれらの配列から重複したも
のを除くことによって、既知の嗅覚受容体遺伝子２０３
種類と、既知の味覚受容体遺伝子１１種類と、嗅覚受容
体や味覚受容体以外の既知のＧＰＣＲ遺伝子６４種類を
同定することができた。一方、ＢＬＡＳＴ検索により既
知のＧＰＣＲ遺伝子とホモロジーをもつ、嗅覚受容体や
味覚受容体以外の新規なＧＰＣＲ遺伝子や、嗅覚受容体
の新規なＧＰＣＲ遺伝子や、味覚受容体の新規なＧＰＣ
Ｒ遺伝子を得ることができた。
３万個のＯＲＦをＳＯＳＵＩにより分析した結果、膜貫
通領域を６〜８個含むＯＲＦが１１５０個得られた。得
られたＧＰＣＲ候補１１５０個のＯＲＦの配列を、ＢＬ
ＡＳＴを用いて２０００年８月２０日現在のデータベー
ス“ｎｒ”と照会し、既知のＧＰＣＲとの相同性を調べ
てみた結果、既知のＧＰＣＲとホモロジーを持つものが
５２２個得られた。さらにこれらの配列から重複したも
のを除くことによって、既知の嗅覚受容体遺伝子２０３
種類と、既知の味覚受容体遺伝子１１種類と、嗅覚受容
体や味覚受容体以外の既知のＧＰＣＲ遺伝子６４種類を
同定することができた。一方、ＢＬＡＳＴ検索により既
知のＧＰＣＲ遺伝子とホモロジーをもつ、嗅覚受容体や
味覚受容体以外の新規なＧＰＣＲ遺伝子や、嗅覚受容体
の新規なＧＰＣＲ遺伝子や、味覚受容体の新規なＧＰＣ
Ｒ遺伝子を得ることができた。
【００４０】［アミノ酸配列による解析］上記ＢＬＡＳ
Ｔ検索により得られた新規なＧＰＣＲ遺伝子につき、ア
ミノ酸配列による解析を行った。アミノ酸配列の解析と
しては、上記ＳＯＳＵＩ以外にシグナル配列の同定をＰ
ＳＯＲＴを用いて行い、さらに膜貫通領域間のループの
長さが妥当であるかなどについて検討した。また、遺伝
子配列についてはＯＲＦが偽遺伝子である可能性を判断
するには、ＯＲＦの上流にＴＡＴＡｂｏｘやＣｐＧｉｓ
ｌａｎｄが存在するかどうかを検索してみた。その結
果、嗅覚及び味覚受容体以外の新規のＧＰＣＲと推測で
きるＯＲＦが５１種類、嗅覚受容体の新規なＧＰＣＲと
推測できるＯＲＦが２８１種類（うち２１８種類は嗅覚
受容体に特異的な配列を有していた）、味覚受容体の新
規なＧＰＣＲと推測できるＯＲＦが１５種類確認でき
た。上記５１種類の嗅覚及び味覚受容体以外の新規のＧ
ＰＣＲの塩基配列を配列番号２ｎ−１（ｎ＝１から５１
までのいずれかの整数を示す）に示し、これら５１種類
の新規ＧＰＣＲ遺伝子がコードする新規ＧＰＣＲ蛋白質
のアミノ酸配列を配列番号２ｎ（ｎ＝１から５１までの
いずれかの整数を示す）に示す。また、２８１種類の嗅
覚受容体の新規ＧＰＣＲ遺伝子の塩基配列を配列番号２
ｎ−１（ｎ＝５２から３３２までのいずれかの整数を示
す）に示し、これら２８１種類の嗅覚受容体の新規ＧＰ
ＣＲ蛋白質のアミノ酸配列を配列番号２ｎ（ｎ＝５２か
ら３３２までのいずれかの整数を示す）に示す。１５種
類の味覚受容体の新規ＧＰＣＲ遺伝子の塩基配列につい
ては配列番号２ｎ−１（ｎ＝３３３から３４７までのい
ずれかの整数を示す）に示し、かかる１５種類の味覚受
容体の新規ＧＰＣＲ蛋白質のアミノ酸配列を配列番号２
ｎ（ｎ＝３３３から３４７までのいずれかの整数を示
す）に示す。
Ｔ検索により得られた新規なＧＰＣＲ遺伝子につき、ア
ミノ酸配列による解析を行った。アミノ酸配列の解析と
しては、上記ＳＯＳＵＩ以外にシグナル配列の同定をＰ
ＳＯＲＴを用いて行い、さらに膜貫通領域間のループの
長さが妥当であるかなどについて検討した。また、遺伝
子配列についてはＯＲＦが偽遺伝子である可能性を判断
するには、ＯＲＦの上流にＴＡＴＡｂｏｘやＣｐＧｉｓ
ｌａｎｄが存在するかどうかを検索してみた。その結
果、嗅覚及び味覚受容体以外の新規のＧＰＣＲと推測で
きるＯＲＦが５１種類、嗅覚受容体の新規なＧＰＣＲと
推測できるＯＲＦが２８１種類（うち２１８種類は嗅覚
受容体に特異的な配列を有していた）、味覚受容体の新
規なＧＰＣＲと推測できるＯＲＦが１５種類確認でき
た。上記５１種類の嗅覚及び味覚受容体以外の新規のＧ
ＰＣＲの塩基配列を配列番号２ｎ−１（ｎ＝１から５１
までのいずれかの整数を示す）に示し、これら５１種類
の新規ＧＰＣＲ遺伝子がコードする新規ＧＰＣＲ蛋白質
のアミノ酸配列を配列番号２ｎ（ｎ＝１から５１までの
いずれかの整数を示す）に示す。また、２８１種類の嗅
覚受容体の新規ＧＰＣＲ遺伝子の塩基配列を配列番号２
ｎ−１（ｎ＝５２から３３２までのいずれかの整数を示
す）に示し、これら２８１種類の嗅覚受容体の新規ＧＰ
ＣＲ蛋白質のアミノ酸配列を配列番号２ｎ（ｎ＝５２か
ら３３２までのいずれかの整数を示す）に示す。１５種
類の味覚受容体の新規ＧＰＣＲ遺伝子の塩基配列につい
ては配列番号２ｎ−１（ｎ＝３３３から３４７までのい
ずれかの整数を示す）に示し、かかる１５種類の味覚受
容体の新規ＧＰＣＲ蛋白質のアミノ酸配列を配列番号２
ｎ（ｎ＝３３３から３４７までのいずれかの整数を示
す）に示す。
【００４１】上記３４７種類の新規ＧＰＣＲ蛋白質の膜
貫通領域（ＴＭ）と、アミノ酸レベルでのホモロジーが
最も高かった蛋白質名を以下に示す。なお、ＴＭの次の
数値は膜貫通領域の番号を表し、それに続く数値範囲は
膜貫通領域を構成する部分のアミノ酸残基の配列表にお
ける番号を示し、アミノ酸残基の配列表における番号に
続く（Ｐ）は膜貫通領域としての性質が非常に明確なこ
とを、（Ｓ）は膜貫通領域としての性質がやや弱いこと
を示す。また、アミノ酸レベルでのホモロジーが最も高
かった蛋白質名に続く数値は、アクセッションナンバー
を示し、全アミノ酸に対する完全に一致するアミノ算数
とその割合（％）を示す。またその後に、ＲＴ−ＰＣＲ
により発現部位が確認できたものについてはその発現部
位を示す。
貫通領域（ＴＭ）と、アミノ酸レベルでのホモロジーが
最も高かった蛋白質名を以下に示す。なお、ＴＭの次の
数値は膜貫通領域の番号を表し、それに続く数値範囲は
膜貫通領域を構成する部分のアミノ酸残基の配列表にお
ける番号を示し、アミノ酸残基の配列表における番号に
続く（Ｐ）は膜貫通領域としての性質が非常に明確なこ
とを、（Ｓ）は膜貫通領域としての性質がやや弱いこと
を示す。また、アミノ酸レベルでのホモロジーが最も高
かった蛋白質名に続く数値は、アクセッションナンバー
を示し、全アミノ酸に対する完全に一致するアミノ算数
とその割合（％）を示す。またその後に、ＲＴ−ＰＣＲ
により発現部位が確認できたものについてはその発現部
位を示す。
【００４２】配列番号２［ＴＭ１；２６−５０(Ｐ)、Ｔ
Ｍ２；５９−８３（Ｐ）、ＴＭ３；９２−１１６
（Ｐ）、ＴＭ４；１３０−１５４（Ｐ）、ＴＭ５；１６
８−１９２（Ｐ）、ＴＭ６；２０３−２２７（Ｐ）、Ｔ
Ｍ７；２４１―２６５（Ｐ）］ retinoic acid induced 3 （putative G protein-coupl
ed receptor）(AF095448)；138/290 (47%) 脾臓、肺、心臓、肝臓、腎臓、膵臓、小腸、大腸 配列番号４［ＴＭ１；１７−４０（Ｓ）、ＴＭ２；６６
−８８（Ｐ）、ＴＭ３；９９−１２３（Ｓ）、ＴＭ４；
１３８−１６２（Ｓ）、ＴＭ５；２２２−２４６
（Ｐ）、ＴＭ６；２５６−２８０（Ｐ）］ hypothetical protein P1.11659_3 - human(AC00447
2)；302/307 (98%) 心臓、大腸 配列番号６［ＴＭ１；１−２１（Ｓ）、ＴＭ２；９２−
１１６（Ｐ）、ＴＭ３；１２６−１４８（Ｐ）、ＴＭ
４；１７７−１９７（Ｓ）、ＴＭ５；２０７−２３１
（Ｓ）、ＴＭ６；２５５−２７９（Ｐ）、ＴＭ７；２９
８−３２２（Ｐ）］ putative chemokine receptor; GTP-binding protein
（PROTEIN-COUPLED RECEPTOR HM74）(D10923)；122/294
(41%) 配列番号８［ＴＭ１；１８−４２（Ｐ）、ＴＭ２；４９
−７３（Ｓ）、ＴＭ３；１００―１２０（Ｓ）、ＴＭ
４；１３８―１６２（Ｐ）、ＴＭ５；１７８−２０２
（Ｓ）、ＴＭ６；２１９−２４３（Ｐ）］ putative chemokine receptor; GTP-binding protein
（PROTEIN-COUPLED RECEPTOR HM74）(D10923)；178/341
(52%) 配列番号１０［ＴＭ１；３１−５５（Ｐ）、ＴＭ２；６
５−８９（Ｐ）、ＴＭ３；９９−１２３（Ｓ）、ＴＭ
４；１５４−１７８（Ｐ）、ＴＭ５；１９４−２１８
（Ｐ）、ＴＭ６；２４２−２６６（Ｓ）、ＴＭ７；２７
４―２９８（Ｐ）］ FML1_GORGO FMLP-RELATED RECEPTOR I (X97738)；90/32
4 (27%)
Ｍ２；５９−８３（Ｐ）、ＴＭ３；９２−１１６
（Ｐ）、ＴＭ４；１３０−１５４（Ｐ）、ＴＭ５；１６
８−１９２（Ｐ）、ＴＭ６；２０３−２２７（Ｐ）、Ｔ
Ｍ７；２４１―２６５（Ｐ）］ retinoic acid induced 3 （putative G protein-coupl
ed receptor）(AF095448)；138/290 (47%) 脾臓、肺、心臓、肝臓、腎臓、膵臓、小腸、大腸 配列番号４［ＴＭ１；１７−４０（Ｓ）、ＴＭ２；６６
−８８（Ｐ）、ＴＭ３；９９−１２３（Ｓ）、ＴＭ４；
１３８−１６２（Ｓ）、ＴＭ５；２２２−２４６
（Ｐ）、ＴＭ６；２５６−２８０（Ｐ）］ hypothetical protein P1.11659_3 - human(AC00447
2)；302/307 (98%) 心臓、大腸 配列番号６［ＴＭ１；１−２１（Ｓ）、ＴＭ２；９２−
１１６（Ｐ）、ＴＭ３；１２６−１４８（Ｐ）、ＴＭ
４；１７７−１９７（Ｓ）、ＴＭ５；２０７−２３１
（Ｓ）、ＴＭ６；２５５−２７９（Ｐ）、ＴＭ７；２９
８−３２２（Ｐ）］ putative chemokine receptor; GTP-binding protein
（PROTEIN-COUPLED RECEPTOR HM74）(D10923)；122/294
(41%) 配列番号８［ＴＭ１；１８−４２（Ｐ）、ＴＭ２；４９
−７３（Ｓ）、ＴＭ３；１００―１２０（Ｓ）、ＴＭ
４；１３８―１６２（Ｐ）、ＴＭ５；１７８−２０２
（Ｓ）、ＴＭ６；２１９−２４３（Ｐ）］ putative chemokine receptor; GTP-binding protein
（PROTEIN-COUPLED RECEPTOR HM74）(D10923)；178/341
(52%) 配列番号１０［ＴＭ１；３１−５５（Ｐ）、ＴＭ２；６
５−８９（Ｐ）、ＴＭ３；９９−１２３（Ｓ）、ＴＭ
４；１５４−１７８（Ｐ）、ＴＭ５；１９４−２１８
（Ｐ）、ＴＭ６；２４２−２６６（Ｓ）、ＴＭ７；２７
４―２９８（Ｐ）］ FML1_GORGO FMLP-RELATED RECEPTOR I (X97738)；90/32
4 (27%)
【００４３】配列番号１２［ＴＭ１；２４−４８
（Ｐ）、ＴＭ２；６９−９０（Ｓ）、ＴＭ３；９６−１
２０（Ｓ）、ＴＭ４；１３５−１５９（Ｐ）、ＴＭ５；
１８６−２１０（Ｐ）、ＴＭ６；２３１−２５１
（Ｐ）、ＴＭ７；２７７−３０１（Ｐ）］ P2Y5_CHICK P2Y PURINOCEPTOR 5 (P2Y5) （protein-cou
pled receptor）(L06109)；113/284 (39%) 配列番号１４［ＴＭ１；３７−６１（Ｐ）、ＴＭ２；８
０−１０２（Ｓ）、ＴＭ３；１１８−１４２（Ｐ）、Ｔ
Ｍ４；１５０−１７４（Ｐ）、ＴＭ５；２００−２２２
（Ｐ）、ＴＭ６；２４０−２６４（Ｐ）］ purinergic receptor P2Y, G-protein coupled 1 (U228
29)；109/299 (36%) 脳、脾臓、肺、肝臓、大腸 配列番号１６［ＴＭ１；２７−５１（Ｐ）、ＴＭ２；６
９−９３（Ｐ）、ＴＭ３；１０３−１２４（Ｓ）、ＴＭ
４；１４４−１６８（Ｐ）、ＴＭ５；１８５−２０９
（Ｐ）、ＴＭ６；２２３−２４７（Ｐ）、ＴＭ７；２６
７−２９１（Ｓ）］MAS1 oncogene (J03823)；111/294
(37%) 心臓、小腸、大腸 配列番号１８［ＴＭ１；８−３２（Ｐ）、ＴＭ２；６１
−８５（Ｓ）、ＴＭ３；９２−１１６（Ｓ）、ＴＭ４；
１５４−１７８（Ｐ）、ＴＭ５；１９６−２２０
（Ｐ）、ＴＭ６；２５０−２７４（Ｐ）］ G-protein coupled receptor GPR34 (AF039686)；77/32
3 (23%) 脳、脾臓、肺、心臓、肺、腎臓、膵臓、胃、小腸、大腸 配列番号２０［ＴＭ１；５−２３（Ｓ）、ＴＭ２；５０
−７４（Ｐ）、ＴＭ３；８７−１１１（Ｓ）、ＴＭ４；
１２３―１４７（Ｐ）、ＴＭ５；１６５−１８９
（Ｐ）、ＴＭ６；２１１−２３５（Ｐ）］ 5-hydroxytryptamine (serotonin) receptor 1D (AB041
379)；72/272 (26%) 膵臓
（Ｐ）、ＴＭ２；６９−９０（Ｓ）、ＴＭ３；９６−１
２０（Ｓ）、ＴＭ４；１３５−１５９（Ｐ）、ＴＭ５；
１８６−２１０（Ｐ）、ＴＭ６；２３１−２５１
（Ｐ）、ＴＭ７；２７７−３０１（Ｐ）］ P2Y5_CHICK P2Y PURINOCEPTOR 5 (P2Y5) （protein-cou
pled receptor）(L06109)；113/284 (39%) 配列番号１４［ＴＭ１；３７−６１（Ｐ）、ＴＭ２；８
０−１０２（Ｓ）、ＴＭ３；１１８−１４２（Ｐ）、Ｔ
Ｍ４；１５０−１７４（Ｐ）、ＴＭ５；２００−２２２
（Ｐ）、ＴＭ６；２４０−２６４（Ｐ）］ purinergic receptor P2Y, G-protein coupled 1 (U228
29)；109/299 (36%) 脳、脾臓、肺、肝臓、大腸 配列番号１６［ＴＭ１；２７−５１（Ｐ）、ＴＭ２；６
９−９３（Ｐ）、ＴＭ３；１０３−１２４（Ｓ）、ＴＭ
４；１４４−１６８（Ｐ）、ＴＭ５；１８５−２０９
（Ｐ）、ＴＭ６；２２３−２４７（Ｐ）、ＴＭ７；２６
７−２９１（Ｓ）］MAS1 oncogene (J03823)；111/294
(37%) 心臓、小腸、大腸 配列番号１８［ＴＭ１；８−３２（Ｐ）、ＴＭ２；６１
−８５（Ｓ）、ＴＭ３；９２−１１６（Ｓ）、ＴＭ４；
１５４−１７８（Ｐ）、ＴＭ５；１９６−２２０
（Ｐ）、ＴＭ６；２５０−２７４（Ｐ）］ G-protein coupled receptor GPR34 (AF039686)；77/32
3 (23%) 脳、脾臓、肺、心臓、肺、腎臓、膵臓、胃、小腸、大腸 配列番号２０［ＴＭ１；５−２３（Ｓ）、ＴＭ２；５０
−７４（Ｐ）、ＴＭ３；８７−１１１（Ｓ）、ＴＭ４；
１２３―１４７（Ｐ）、ＴＭ５；１６５−１８９
（Ｐ）、ＴＭ６；２１１−２３５（Ｐ）］ 5-hydroxytryptamine (serotonin) receptor 1D (AB041
379)；72/272 (26%) 膵臓
【００４４】配列番号２２［ＴＭ１；２−２４（Ｐ）、
ＴＭ２；２９−５３（Ｐ）、ＴＭ３；６４−８８
（Ｓ）、ＴＭ４；９４−１１７（Ｐ）、ＴＭ５；２１３
−２３７（Ｐ）、ＴＭ６；２９７−３２１（Ｓ）］ CG2114 gene product (AE003476)；71/302 (23%) 胃、小腸 配列番号２４［ＴＭ１；３７−６１（Ｐ）、ＴＭ２；７
６−１００（Ｓ）、ＴＭ３；１１３−１３７（Ｐ）、Ｔ
Ｍ４；１５１−１７５（Ｐ）、ＴＭ５；１８９−２１３
（Ｐ）、ＴＭ６；２５０−２７４（Ｐ）、ＴＭ７；２９
０−３１０（Ｓ）］ sphingosine 1-phosphate receptor Edg-8 (AF22364
9)；343/397 (86%) 配列番号２６［ＴＭ１；２５−４９（Ｐ）、ＴＭ２；５
８−８２（Ｓ）、ＴＭ３；９７−１２１（Ｐ）、ＴＭ
４；１３８−１６２（Ｐ）、ＴＭ５；１８４−２０８
（Ｐ）、ＴＭ６；２３３−２５４（Ｐ）、ＴＭ７；２７
４−２９３（Ｓ）］ gene product; putative G-protein-coupled receptor;
G protein coupled receptor for UDP-glucose (D136
26)；149/314 (47%) 脳、脾臓、心臓、胃、大腸 配列番号２８［ＴＭ１；３９−６３（Ｐ）、ＴＭ２；７
２−９６（Ｓ）、ＴＭ３；１４８−１７０（Ｐ）、ＴＭ
４；２０２−２２５（Ｐ）、ＴＭ５；２４８−２７２
（Ｐ）、ＴＭ６；２８６−３１０（Ｓ）］ GALS_MOUSE GALANIN RECEPTOR TYPE 2 (AF042784)；109
/299 (36%) 膵臓 配列番号３０［ＴＭ１；４３−６７（Ｐ）、ＴＭ２；７
９−１０３（Ｐ）、ＴＭ３；１１３−１３７（Ｐ）、Ｔ
Ｍ４；１５４−１７４（Ｓ）、ＴＭ５；２０６−２３０
（Ｐ）、ＴＭ６；２８７−３１１（Ｐ）、ＴＭ７；３２
４―３４５（Ｓ）］ PROBABLE G PROTEIN-COUPLED RECEPTOR (D43633)；179/
429 (41%)
ＴＭ２；２９−５３（Ｐ）、ＴＭ３；６４−８８
（Ｓ）、ＴＭ４；９４−１１７（Ｐ）、ＴＭ５；２１３
−２３７（Ｐ）、ＴＭ６；２９７−３２１（Ｓ）］ CG2114 gene product (AE003476)；71/302 (23%) 胃、小腸 配列番号２４［ＴＭ１；３７−６１（Ｐ）、ＴＭ２；７
６−１００（Ｓ）、ＴＭ３；１１３−１３７（Ｐ）、Ｔ
Ｍ４；１５１−１７５（Ｐ）、ＴＭ５；１８９−２１３
（Ｐ）、ＴＭ６；２５０−２７４（Ｐ）、ＴＭ７；２９
０−３１０（Ｓ）］ sphingosine 1-phosphate receptor Edg-8 (AF22364
9)；343/397 (86%) 配列番号２６［ＴＭ１；２５−４９（Ｐ）、ＴＭ２；５
８−８２（Ｓ）、ＴＭ３；９７−１２１（Ｐ）、ＴＭ
４；１３８−１６２（Ｐ）、ＴＭ５；１８４−２０８
（Ｐ）、ＴＭ６；２３３−２５４（Ｐ）、ＴＭ７；２７
４−２９３（Ｓ）］ gene product; putative G-protein-coupled receptor;
G protein coupled receptor for UDP-glucose (D136
26)；149/314 (47%) 脳、脾臓、心臓、胃、大腸 配列番号２８［ＴＭ１；３９−６３（Ｐ）、ＴＭ２；７
２−９６（Ｓ）、ＴＭ３；１４８−１７０（Ｐ）、ＴＭ
４；２０２−２２５（Ｐ）、ＴＭ５；２４８−２７２
（Ｐ）、ＴＭ６；２８６−３１０（Ｓ）］ GALS_MOUSE GALANIN RECEPTOR TYPE 2 (AF042784)；109
/299 (36%) 膵臓 配列番号３０［ＴＭ１；４３−６７（Ｐ）、ＴＭ２；７
９−１０３（Ｐ）、ＴＭ３；１１３−１３７（Ｐ）、Ｔ
Ｍ４；１５４−１７４（Ｓ）、ＴＭ５；２０６−２３０
（Ｐ）、ＴＭ６；２８７−３１１（Ｐ）、ＴＭ７；３２
４―３４５（Ｓ）］ PROBABLE G PROTEIN-COUPLED RECEPTOR (D43633)；179/
429 (41%)
【００４５】配列番号３２［ＴＭ１；１３５−１５７
（Ｓ）、ＴＭ２；１６１−１８４（Ｐ）、ＴＭ３；１９
１−２１５（Ｐ）、ＴＭ４；２３０−２５４（Ｐ）、Ｔ
Ｍ５；２６６−２９０（Ｐ）、ＴＭ６；３１８−３４２
（Ｐ）］ seven transmembrane receptor (AB019120)；71/302 (2
3%) 配列番号３４［ＴＭ１；４３−６７（Ｐ）、ＴＭ２；７
９−１０３（Ｐ）、ＴＭ３；１１３−１３７（Ｐ）、Ｔ
Ｍ４；１５４−１７８（Ｓ）、ＴＭ５；２０６−２３０
（Ｐ）、ＴＭ６；２８０−３０２（Ｐ）、ＴＭ７；３１
２−３３６（Ｐ）］ PROBABLE G PROTEIN-COUPLED RECEPTOR (D43633)；125/
312 (40%) 配列番号３６［ＴＭ１；３８−６２（Ｐ）、ＴＭ２；８
９−１１３（Ｓ）、ＴＭ３；１１８−１４２（Ｐ）、Ｔ
Ｍ４；１６４−１８８（Ｐ）、ＴＭ５；２０８−２３２
（Ｐ）、ＴＭ６；２４８−２７２（Ｓ）、ＴＭ７；２７
６−２９８（Ｓ）］ G-protein coupled receptor SALPR; somatostatin and
angiotensin-like（ G-protein coupled receptor SAL
PR） (D88437)；141/322 (43%) 腎臓、小腸 配列番号３８［ＴＭ１；７−３１（Ｐ）、ＴＭ２；４２
−６６（Ｓ）、ＴＭ３；７９−１０３（Ｓ）、ＴＭ４；
１２０−１４４（Ｐ）、ＴＭ５；１５９−１８３
（Ｐ）、ＴＭ６；２２４−２４８（Ｐ）、ＴＭ７；２６
４−２８８（Ｓ）］ DOP1_DROME DOPAMINE RECEPTOR 1 PRECURSOR (D-DOP1)
(X77234)；95/350 (27%) 配列番号４０［ＴＭ１；３−２７（Ｓ）、ＴＭ２；３６
−６０（Ｐ）、ＴＭ３；６４−８７（Ｓ）、ＴＭ４；９
４−１１６（Ｓ）、ＴＭ５；２１３−２３１（Ｓ）、Ｔ
Ｍ６；２５１−２７３（Ｐ）］ cadherin EGF LAG seven-pass G-type receptor (AF031
572)；40/112 (35%)
（Ｓ）、ＴＭ２；１６１−１８４（Ｐ）、ＴＭ３；１９
１−２１５（Ｐ）、ＴＭ４；２３０−２５４（Ｐ）、Ｔ
Ｍ５；２６６−２９０（Ｐ）、ＴＭ６；３１８−３４２
（Ｐ）］ seven transmembrane receptor (AB019120)；71/302 (2
3%) 配列番号３４［ＴＭ１；４３−６７（Ｐ）、ＴＭ２；７
９−１０３（Ｐ）、ＴＭ３；１１３−１３７（Ｐ）、Ｔ
Ｍ４；１５４−１７８（Ｓ）、ＴＭ５；２０６−２３０
（Ｐ）、ＴＭ６；２８０−３０２（Ｐ）、ＴＭ７；３１
２−３３６（Ｐ）］ PROBABLE G PROTEIN-COUPLED RECEPTOR (D43633)；125/
312 (40%) 配列番号３６［ＴＭ１；３８−６２（Ｐ）、ＴＭ２；８
９−１１３（Ｓ）、ＴＭ３；１１８−１４２（Ｐ）、Ｔ
Ｍ４；１６４−１８８（Ｐ）、ＴＭ５；２０８−２３２
（Ｐ）、ＴＭ６；２４８−２７２（Ｓ）、ＴＭ７；２７
６−２９８（Ｓ）］ G-protein coupled receptor SALPR; somatostatin and
angiotensin-like（ G-protein coupled receptor SAL
PR） (D88437)；141/322 (43%) 腎臓、小腸 配列番号３８［ＴＭ１；７−３１（Ｐ）、ＴＭ２；４２
−６６（Ｓ）、ＴＭ３；７９−１０３（Ｓ）、ＴＭ４；
１２０−１４４（Ｐ）、ＴＭ５；１５９−１８３
（Ｐ）、ＴＭ６；２２４−２４８（Ｐ）、ＴＭ７；２６
４−２８８（Ｓ）］ DOP1_DROME DOPAMINE RECEPTOR 1 PRECURSOR (D-DOP1)
(X77234)；95/350 (27%) 配列番号４０［ＴＭ１；３−２７（Ｓ）、ＴＭ２；３６
−６０（Ｐ）、ＴＭ３；６４−８７（Ｓ）、ＴＭ４；９
４−１１６（Ｓ）、ＴＭ５；２１３−２３１（Ｓ）、Ｔ
Ｍ６；２５１−２７３（Ｐ）］ cadherin EGF LAG seven-pass G-type receptor (AF031
572)；40/112 (35%)
【００４６】配列番号４２［ＴＭ１；２７−５１
（Ｓ）、ＴＭ２；１０３−１２２（Ｓ）、ＴＭ３；１３
９−１６０（Ｐ）、ＴＭ４；１８０−２０４（Ｓ）、Ｔ
Ｍ５；２２１−２４５（Ｐ）、ＴＭ６；２６３−２８１
（Ｓ）］ RTA_RAT PROBABLE G PROTEIN-COUPLED RECEPTOR RTA (M
35297)；120/332 (36%) 配列番号４４［ＴＭ１；２８−５２（Ｐ）、ＴＭ２；６
３−８７（Ｐ）、ＴＭ３；９５−１１７（Ｐ）、ＴＭ
４；１４１−１６５（Ｐ）、ＴＭ５；１７９−２０３
（Ｐ）、ＴＭ６；２１６−２４０（Ｐ）、ＴＭ７；２５
２−２７６（Ｓ）］ MAS1 oncogene (J03823)；108/283 (38%) 脾臓、肺、大腸 配列番号４６［ＴＭ１；１８−４２（Ｓ）、ＴＭ２；９
６−１２０（Ｐ）、ＴＭ３；１４０−１６４（Ｐ）、Ｔ
Ｍ４；１７８−２０２（Ｐ）、ＴＭ５；３１８−３４２
（Ｐ）、ＴＭ６；３５３−３７４（Ｓ）］ (AE003422) EG:22E5.11 gene product (AE003422)；98/
364 (26%) 肺 配列番号４８［ＴＭ１；１２−３６（Ｐ）、ＴＭ２；４
７−７１（Ｓ）、ＴＭ３；９７−１２１（Ｐ）、ＴＭ
４；１３３−１５７（Ｓ）、ＴＭ５；１８３−２０７
（Ｐ）、ＴＭ６；２２６−２５０（Ｐ）］ frizzled 6 (AB012911)；286/314 (91%) 配列番号５０［ＴＭ１；１６−４０（Ｐ）、ＴＭ２；４
５−６９（Ｓ）、ＴＭ３；８０−１０４（Ｐ）、ＴＭ
４；１１６−１３８（Ｓ）、ＴＭ５；１６４−１８８
（Ｓ）、ＴＭ６；２７８−３０２（Ｐ）、ＴＭ７；３５
４−３７８（Ｐ）］ unnamed protein product (AK000922)；286/370 (77%)
（Ｓ）、ＴＭ２；１０３−１２２（Ｓ）、ＴＭ３；１３
９−１６０（Ｐ）、ＴＭ４；１８０−２０４（Ｓ）、Ｔ
Ｍ５；２２１−２４５（Ｐ）、ＴＭ６；２６３−２８１
（Ｓ）］ RTA_RAT PROBABLE G PROTEIN-COUPLED RECEPTOR RTA (M
35297)；120/332 (36%) 配列番号４４［ＴＭ１；２８−５２（Ｐ）、ＴＭ２；６
３−８７（Ｐ）、ＴＭ３；９５−１１７（Ｐ）、ＴＭ
４；１４１−１６５（Ｐ）、ＴＭ５；１７９−２０３
（Ｐ）、ＴＭ６；２１６−２４０（Ｐ）、ＴＭ７；２５
２−２７６（Ｓ）］ MAS1 oncogene (J03823)；108/283 (38%) 脾臓、肺、大腸 配列番号４６［ＴＭ１；１８−４２（Ｓ）、ＴＭ２；９
６−１２０（Ｐ）、ＴＭ３；１４０−１６４（Ｐ）、Ｔ
Ｍ４；１７８−２０２（Ｐ）、ＴＭ５；３１８−３４２
（Ｐ）、ＴＭ６；３５３−３７４（Ｓ）］ (AE003422) EG:22E5.11 gene product (AE003422)；98/
364 (26%) 肺 配列番号４８［ＴＭ１；１２−３６（Ｐ）、ＴＭ２；４
７−７１（Ｓ）、ＴＭ３；９７−１２１（Ｐ）、ＴＭ
４；１３３−１５７（Ｓ）、ＴＭ５；１８３−２０７
（Ｐ）、ＴＭ６；２２６−２５０（Ｐ）］ frizzled 6 (AB012911)；286/314 (91%) 配列番号５０［ＴＭ１；１６−４０（Ｐ）、ＴＭ２；４
５−６９（Ｓ）、ＴＭ３；８０−１０４（Ｐ）、ＴＭ
４；１１６−１３８（Ｓ）、ＴＭ５；１６４−１８８
（Ｓ）、ＴＭ６；２７８−３０２（Ｐ）、ＴＭ７；３５
４−３７８（Ｐ）］ unnamed protein product (AK000922)；286/370 (77%)
【００４７】配列番号５２［ＴＭ１；６４−８８
（Ｐ）、ＴＭ２；９８−１２０（Ｐ）、ＴＭ３；１２２
−１４６（Ｓ）、ＴＭ４；１７２−１９６（Ｐ）、ＴＭ
５；２１３−２３７（Ｓ）、ＴＭ６；２５３−２７７
（Ｐ）、ＴＭ７；２８４−３０８（Ｐ）］ putative pheromone receptor V2R2 (AF053989)；250/3
27 (76%) 鼻 配列番号５４［ＴＭ１；８４−１０６（Ｐ）、ＴＭ２；
１１０−１３２（Ｐ）、ＴＭ３；１３６−１５８
（Ｐ）、ＴＭ４；１７３−１９４（Ｐ）、ＴＭ５；２０
０−２２４（Ｐ）、ＴＭ６；２３０−２５１（Ｐ）、Ｔ
Ｍ７；２６７−２９１（Ｐ）］ ins ulin-like growth factor I, brain-specific - Th
ai catfish (A53697)；28/88 (31%) 配列番号５６［ＴＭ１；９０−１１４（Ｓ）、ＴＭ２；
１１７−１４０（Ｓ）、ＴＭ３；１５１−１６８
（Ｓ）、ＴＭ４；１７４−１９８（Ｐ）、ＴＭ５；２０
９−２３３（Ｓ）、ＴＭ６；２３８−２６２（Ｐ）］ hypothetical protein T06E4.7 - Caenorhabditis eleg
ans (Z70756)；25/67 (37%) 肺 配列番号５８［ＴＭ１；４０−６４（Ｐ）、ＴＭ２；７
１−９５（Ｓ）、ＴＭ３；１２４−１４８（Ｐ）、ＴＭ
４；１５３−１７７（Ｐ）、ＴＭ５；２０４−２２８
（Ｐ）、ＴＭ６；２４３−２６５（Ｐ）、ＴＭ７；２８
３−３０７（Ｓ）］ cysteinyl leukotriene receptor 1 (AF119711)；114/2
98 (38%) 配列番号６０［ＴＭ１；１６−３８（Ｐ）、ＴＭ２；５
１−７３（Ｐ）、ＴＭ３；９１−１１３（Ｐ）、ＴＭ
４；１３３−１５５（Ｓ）、ＴＭ５；１７８−１９９
（Ｐ）、ＴＭ６；２７１−２９３（Ｓ）］ G protein-coupled seven-transmembrane receptor(D43
633)；117/365 (32%)
（Ｐ）、ＴＭ２；９８−１２０（Ｐ）、ＴＭ３；１２２
−１４６（Ｓ）、ＴＭ４；１７２−１９６（Ｐ）、ＴＭ
５；２１３−２３７（Ｓ）、ＴＭ６；２５３−２７７
（Ｐ）、ＴＭ７；２８４−３０８（Ｐ）］ putative pheromone receptor V2R2 (AF053989)；250/3
27 (76%) 鼻 配列番号５４［ＴＭ１；８４−１０６（Ｐ）、ＴＭ２；
１１０−１３２（Ｐ）、ＴＭ３；１３６−１５８
（Ｐ）、ＴＭ４；１７３−１９４（Ｐ）、ＴＭ５；２０
０−２２４（Ｐ）、ＴＭ６；２３０−２５１（Ｐ）、Ｔ
Ｍ７；２６７−２９１（Ｐ）］ ins ulin-like growth factor I, brain-specific - Th
ai catfish (A53697)；28/88 (31%) 配列番号５６［ＴＭ１；９０−１１４（Ｓ）、ＴＭ２；
１１７−１４０（Ｓ）、ＴＭ３；１５１−１６８
（Ｓ）、ＴＭ４；１７４−１９８（Ｐ）、ＴＭ５；２０
９−２３３（Ｓ）、ＴＭ６；２３８−２６２（Ｐ）］ hypothetical protein T06E4.7 - Caenorhabditis eleg
ans (Z70756)；25/67 (37%) 肺 配列番号５８［ＴＭ１；４０−６４（Ｐ）、ＴＭ２；７
１−９５（Ｓ）、ＴＭ３；１２４−１４８（Ｐ）、ＴＭ
４；１５３−１７７（Ｐ）、ＴＭ５；２０４−２２８
（Ｐ）、ＴＭ６；２４３−２６５（Ｐ）、ＴＭ７；２８
３−３０７（Ｓ）］ cysteinyl leukotriene receptor 1 (AF119711)；114/2
98 (38%) 配列番号６０［ＴＭ１；１６−３８（Ｐ）、ＴＭ２；５
１−７３（Ｐ）、ＴＭ３；９１−１１３（Ｐ）、ＴＭ
４；１３３−１５５（Ｓ）、ＴＭ５；１７８−１９９
（Ｐ）、ＴＭ６；２７１−２９３（Ｓ）］ G protein-coupled seven-transmembrane receptor(D43
633)；117/365 (32%)
【００４８】配列番号６２［ＴＭ１；１７−３９
（Ｓ）、ＴＭ２；６７−８９（Ｐ）、ＴＭ３；１０１−
１２３（Ｓ）、ＴＭ４；１３５−１５７（Ｐ）、ＴＭ
５；１７８−１９６（Ｓ）、ＴＭ６；２０２−２２１
（Ｓ）］ allatostatin receptor(AF163775)；43/154 (27%) 肺、心臓、膵臓、小腸 配列番号６４［ＴＭ１；９−３１（Ｓ）、ＴＭ２；４８
−７０（Ｓ）、ＴＭ３；９２−１１４（Ｓ）、ＴＭ４；
２０７−２２９（Ｓ）、ＴＭ５；２６９−２９０
（Ｐ）、ＴＭ６；３１５−３３７（Ｐ）、ＴＭ７；３４
８−３７０（Ｐ）］ pheromone receptor VN3(U36895)；84/277 (30%) 鼻 配列番号６６［ＴＭ１；１１８−１４０（Ｐ）、ＴＭ
２；１５３−１７５（Ｓ）、ＴＭ３；１９９−２２１
（Ｓ）、ＴＭ４；２３６−２５８（Ｐ）、ＴＭ５；２８
１−３０３（Ｐ）、ＴＭ６；３２６−３４８（Ｐ）、Ｔ
Ｍ７；３６２−３８４（Ｐ）］ G protein-coupled receptor LGR5(AF061444)；120/269
(44%) 配列番号６８［ＴＭ１；３３−５４（Ｓ）、ＴＭ２；９
７−１１９（Ｐ）、ＴＭ３；１６８−１９０（Ｓ）、Ｔ
Ｍ４；２６４−２８６（Ｐ）、ＴＭ５；２９１−３１３
（Ｓ）、ＴＭ６；４０５−４２７（Ｐ）］ interleukin 9 receptor precursor(L39064)；30/105
(28%) 配列番号７０［ＴＭ１；５−２７（Ｐ）、ＴＭ２；５５
−７６（Ｓ）、ＴＭ３；８５−１０７（Ｐ）、ＴＭ４；
１２６−１４８（Ｓ）、ＴＭ５；１６４−１８６
（Ｐ）、ＴＭ６；２６７−２８９（Ｐ）、ＴＭ７；３０
４−３２６（Ｓ）］ pheromone receptor VN6(U36898)；99/310 (31%) 鼻
（Ｓ）、ＴＭ２；６７−８９（Ｐ）、ＴＭ３；１０１−
１２３（Ｓ）、ＴＭ４；１３５−１５７（Ｐ）、ＴＭ
５；１７８−１９６（Ｓ）、ＴＭ６；２０２−２２１
（Ｓ）］ allatostatin receptor(AF163775)；43/154 (27%) 肺、心臓、膵臓、小腸 配列番号６４［ＴＭ１；９−３１（Ｓ）、ＴＭ２；４８
−７０（Ｓ）、ＴＭ３；９２−１１４（Ｓ）、ＴＭ４；
２０７−２２９（Ｓ）、ＴＭ５；２６９−２９０
（Ｐ）、ＴＭ６；３１５−３３７（Ｐ）、ＴＭ７；３４
８−３７０（Ｐ）］ pheromone receptor VN3(U36895)；84/277 (30%) 鼻 配列番号６６［ＴＭ１；１１８−１４０（Ｐ）、ＴＭ
２；１５３−１７５（Ｓ）、ＴＭ３；１９９−２２１
（Ｓ）、ＴＭ４；２３６−２５８（Ｐ）、ＴＭ５；２８
１−３０３（Ｐ）、ＴＭ６；３２６−３４８（Ｐ）、Ｔ
Ｍ７；３６２−３８４（Ｐ）］ G protein-coupled receptor LGR5(AF061444)；120/269
(44%) 配列番号６８［ＴＭ１；３３−５４（Ｓ）、ＴＭ２；９
７−１１９（Ｐ）、ＴＭ３；１６８−１９０（Ｓ）、Ｔ
Ｍ４；２６４−２８６（Ｐ）、ＴＭ５；２９１−３１３
（Ｓ）、ＴＭ６；４０５−４２７（Ｐ）］ interleukin 9 receptor precursor(L39064)；30/105
(28%) 配列番号７０［ＴＭ１；５−２７（Ｐ）、ＴＭ２；５５
−７６（Ｓ）、ＴＭ３；８５−１０７（Ｐ）、ＴＭ４；
１２６−１４８（Ｓ）、ＴＭ５；１６４−１８６
（Ｐ）、ＴＭ６；２６７−２８９（Ｐ）、ＴＭ７；３０
４−３２６（Ｓ）］ pheromone receptor VN6(U36898)；99/310 (31%) 鼻
【００４９】配列番号７２［ＴＭ１；１−２１（Ｓ）、
ＴＭ２；２７−４３（Ｓ）、ＴＭ３；５１−７３
（Ｓ）、ＴＭ４；９２−１１４（Ｓ）、ＴＭ５；１３１
−１５３（Ｓ）、ＴＭ６；１８３−２０５（Ｐ）］ pheromone receptor 1(Y12725)；64/155 (41%) 鼻 配列番号７４［ＴＭ１；２０−４２（Ｐ）、ＴＭ２；５
０−７２（Ｓ）、ＴＭ３；８４−１０６（Ｐ）、ＴＭ
４；１２３−１４４（Ｐ）、ＴＭ５；１６７−１８９
（Ｓ）、ＴＭ６；２２８−２５０（Ｐ）、ＴＭ７；２５
９−２８１（Ｓ）］ putative G-Protein coupled receptor, EDG6(AJ00047
9)；81/268 (30%) 骨格筋 配列番号７６［ＴＭ１；２１−４３（Ｐ）、ＴＭ２；５
５−７７（Ｐ）、ＴＭ３；１００−１２２（Ｓ）、ＴＭ
４；１３６−１５８（Ｐ）、ＴＭ５；１８１−２０３
（Ｐ）、ＴＭ６；２２７−２４７（Ｐ）、ＴＭ７；２７
０−２７２（Ｓ）］ putative purinergic receptor P2Y10(AF000545)；148/
292 (50%) 配列番号７８［ＴＭ１；２４−４６（Ｐ）、ＴＭ２；５
７−７９（Ｐ）、ＴＭ３；９８−１２０（Ｐ）、ＴＭ
４；１３６−１５８（Ｐ）、ＴＭ５；１８９−２１１
（Ｐ）、ＴＭ６；２３４−２５５（Ｐ）、ＴＭ７；２８
０−３００（Ｓ）］ KIAA0001 gene product(D13626)；140/295 (47%) 脳、胸腺、肺、腎臓、胃、大腸 配列番号８０［ＴＭ１；１−２３（Ｐ）、ＴＭ２；３６
−５８（Ｓ）、ＴＭ３；２４９−２７１（Ｐ）、ＴＭ
４；２９６−３１８（Ｐ）、ＴＭ５；３３２−３５４
（Ｐ）、ＴＭ６；３６８−３９０（Ｐ）、ＴＭ７；４１
２−４３４（Ｐ）、ＴＭ８；４５８−４８０（Ｓ）］ seven transmembrane receptor(AB019120)；191/487 (3
9%)
ＴＭ２；２７−４３（Ｓ）、ＴＭ３；５１−７３
（Ｓ）、ＴＭ４；９２−１１４（Ｓ）、ＴＭ５；１３１
−１５３（Ｓ）、ＴＭ６；１８３−２０５（Ｐ）］ pheromone receptor 1(Y12725)；64/155 (41%) 鼻 配列番号７４［ＴＭ１；２０−４２（Ｐ）、ＴＭ２；５
０−７２（Ｓ）、ＴＭ３；８４−１０６（Ｐ）、ＴＭ
４；１２３−１４４（Ｐ）、ＴＭ５；１６７−１８９
（Ｓ）、ＴＭ６；２２８−２５０（Ｐ）、ＴＭ７；２５
９−２８１（Ｓ）］ putative G-Protein coupled receptor, EDG6(AJ00047
9)；81/268 (30%) 骨格筋 配列番号７６［ＴＭ１；２１−４３（Ｐ）、ＴＭ２；５
５−７７（Ｐ）、ＴＭ３；１００−１２２（Ｓ）、ＴＭ
４；１３６−１５８（Ｐ）、ＴＭ５；１８１−２０３
（Ｐ）、ＴＭ６；２２７−２４７（Ｐ）、ＴＭ７；２７
０−２７２（Ｓ）］ putative purinergic receptor P2Y10(AF000545)；148/
292 (50%) 配列番号７８［ＴＭ１；２４−４６（Ｐ）、ＴＭ２；５
７−７９（Ｐ）、ＴＭ３；９８−１２０（Ｐ）、ＴＭ
４；１３６−１５８（Ｐ）、ＴＭ５；１８９−２１１
（Ｐ）、ＴＭ６；２３４−２５５（Ｐ）、ＴＭ７；２８
０−３００（Ｓ）］ KIAA0001 gene product(D13626)；140/295 (47%) 脳、胸腺、肺、腎臓、胃、大腸 配列番号８０［ＴＭ１；１−２３（Ｐ）、ＴＭ２；３６
−５８（Ｓ）、ＴＭ３；２４９−２７１（Ｐ）、ＴＭ
４；２９６−３１８（Ｐ）、ＴＭ５；３３２−３５４
（Ｐ）、ＴＭ６；３６８−３９０（Ｐ）、ＴＭ７；４１
２−４３４（Ｐ）、ＴＭ８；４５８−４８０（Ｓ）］ seven transmembrane receptor(AB019120)；191/487 (3
9%)
【００５０】配列番号８２［ＴＭ１；５−２５（Ｓ）、
ＴＭ２；８０−９７（Ｓ）、ＴＭ３；１０３−１２４
（Ｐ）、ＴＭ４；１３３−１５５（Ｐ）、ＴＭ５；１６
５−１８７（Ｓ）、ＴＭ６；２１７−２３９（Ｐ）］ unnamed protein product(AK000922)；304/357 (85%) 配列番号８４［ＴＭ１；１６−３４（Ｓ）、ＴＭ２；２
１６−２３８（Ｐ）、ＴＭ３；２４７−２６９（Ｓ）、
ＴＭ４；２８５−３０７（Ｓ）、ＴＭ５；３６７−３８
９（Ｐ）、ＴＭ６；４０３−４２５（Ｐ）］ seven transmembrane receptor(AB019120)；95/326 (29
%) 配列番号８６［ＴＭ１；１−２３（Ｓ）、ＴＭ２；４１
−６３（Ｓ）、ＴＭ３；９５−１１７（Ｐ）、ＴＭ４；
１２８−１５０（Ｐ）、ＴＭ５；１５７−１７９
（Ｐ）、ＴＭ６；１９０−２１２（Ｓ）、ＴＭ７；２１
６−２３８（Ｐ）、ＴＭ８；２６０−２８２（Ｐ）］ neuropeptide Y receptor Y6(U58367)；23/88 (26%) 配列番号８８［ＴＭ１；１４−３６（Ｓ）、ＴＭ２；５
５−７７（Ｐ）、ＴＭ３；９４−１１６（Ｐ）、ＴＭ
４；１２６−１４７（Ｐ）、ＴＭ５；１８５−２０７
（Ｐ）、ＴＭ６；２１５−２３７（Ｓ）］ orphan G protein-coupled receptor(AF045764)；199/2
36 (84%) 配列番号９０［ＴＭ１；３１−５３（Ｐ）、ＴＭ２；６
９−９１（Ｐ）、ＴＭ３；１１０−１３２（Ｓ）、ＴＭ
４；１９５−２１７（Ｐ）、ＴＭ５；４００−４２２
（Ｐ）、ＴＭ６；４３４−４５６（Ｐ）］ G-protein coupled receptor RE2(AF091890)；63/192
(32%)
ＴＭ２；８０−９７（Ｓ）、ＴＭ３；１０３−１２４
（Ｐ）、ＴＭ４；１３３−１５５（Ｐ）、ＴＭ５；１６
５−１８７（Ｓ）、ＴＭ６；２１７−２３９（Ｐ）］ unnamed protein product(AK000922)；304/357 (85%) 配列番号８４［ＴＭ１；１６−３４（Ｓ）、ＴＭ２；２
１６−２３８（Ｐ）、ＴＭ３；２４７−２６９（Ｓ）、
ＴＭ４；２８５−３０７（Ｓ）、ＴＭ５；３６７−３８
９（Ｐ）、ＴＭ６；４０３−４２５（Ｐ）］ seven transmembrane receptor(AB019120)；95/326 (29
%) 配列番号８６［ＴＭ１；１−２３（Ｓ）、ＴＭ２；４１
−６３（Ｓ）、ＴＭ３；９５−１１７（Ｐ）、ＴＭ４；
１２８−１５０（Ｐ）、ＴＭ５；１５７−１７９
（Ｐ）、ＴＭ６；１９０−２１２（Ｓ）、ＴＭ７；２１
６−２３８（Ｐ）、ＴＭ８；２６０−２８２（Ｐ）］ neuropeptide Y receptor Y6(U58367)；23/88 (26%) 配列番号８８［ＴＭ１；１４−３６（Ｓ）、ＴＭ２；５
５−７７（Ｐ）、ＴＭ３；９４−１１６（Ｐ）、ＴＭ
４；１２６−１４７（Ｐ）、ＴＭ５；１８５−２０７
（Ｐ）、ＴＭ６；２１５−２３７（Ｓ）］ orphan G protein-coupled receptor(AF045764)；199/2
36 (84%) 配列番号９０［ＴＭ１；３１−５３（Ｐ）、ＴＭ２；６
９−９１（Ｐ）、ＴＭ３；１１０−１３２（Ｓ）、ＴＭ
４；１９５−２１７（Ｐ）、ＴＭ５；４００−４２２
（Ｐ）、ＴＭ６；４３４−４５６（Ｐ）］ G-protein coupled receptor RE2(AF091890)；63/192
(32%)
【００５１】配列番号９２［ＴＭ１；１−２３（Ｐ）、
ＴＭ２；３６−５８（Ｐ）、ＴＭ３；９９−１２１
（Ｐ）、ＴＭ４；１３５−１５７（Ｓ）、ＴＭ５；１６
５−１８７（Ｐ）、ＴＭ６；１８９−２１１（Ｓ）、Ｔ
Ｍ７；３３９−３６１（Ｐ）、ＴＭ８；３７９−４０１
（Ｓ）］ Frizzled-1 protein homolog(T42210)；27/82 (32%) 配列番号９４［ＴＭ１；２４−４６（Ｐ）、ＴＭ２；８
３−１０５（Ｐ）、ＴＭ３；１２２−１４３（Ｐ）、Ｔ
Ｍ４；１６６−１８８（Ｓ）、ＴＭ５；２２７−２４９
（Ｐ）、ＴＭ６；２５８−２８０（Ｓ）］ putative G-Protein coupled receptor(AJ000479)；76/
268 (28%) 配列番号９６［ＴＭ１；２２−４４（Ｐ）、ＴＭ２；１
１３−１３５（Ｐ）、ＴＭ３；１５９−１８１（Ｐ）、
ＴＭ４；２０３−２２５（Ｓ）、ＴＭ５；２２８−２５
０（Ｐ）、ＴＭ６；２７２−２９４（Ｓ）］ Frizzled-10(AB027464)；23/96 (23%) 配列番号９８［ＴＭ１；１１−３３（Ｓ）、ＴＭ２；４
１−６３（Ｓ）、ＴＭ３；７１−９３（Ｓ）、ＴＭ４；
９６−１１８（Ｐ）、ＴＭ５；１２２−１４４（Ｓ）、
ＴＭ６；１４６−１６５（Ｓ）］ beta3-adrenergic receptor(AF109930)；39/120 (32%) 配列番号１００［ＴＭ１；８−２９（Ｐ）、ＴＭ２；３
１−５２（Ｐ）、ＴＭ３；５５−７３（Ｐ）、ＴＭ４；
７９−１００（Ｐ）、ＴＭ５；１１０−１３２（Ｓ）、
ＴＭ６；１４７−１６９（Ｐ）、ＴＭ７；１７７−１９
９（Ｐ）、ＴＭ８；２０１−２２２（Ｐ）］ putative pheromone receptor V2R1(AF053985)；51/219
(23%)
ＴＭ２；３６−５８（Ｐ）、ＴＭ３；９９−１２１
（Ｐ）、ＴＭ４；１３５−１５７（Ｓ）、ＴＭ５；１６
５−１８７（Ｐ）、ＴＭ６；１８９−２１１（Ｓ）、Ｔ
Ｍ７；３３９−３６１（Ｐ）、ＴＭ８；３７９−４０１
（Ｓ）］ Frizzled-1 protein homolog(T42210)；27/82 (32%) 配列番号９４［ＴＭ１；２４−４６（Ｐ）、ＴＭ２；８
３−１０５（Ｐ）、ＴＭ３；１２２−１４３（Ｐ）、Ｔ
Ｍ４；１６６−１８８（Ｓ）、ＴＭ５；２２７−２４９
（Ｐ）、ＴＭ６；２５８−２８０（Ｓ）］ putative G-Protein coupled receptor(AJ000479)；76/
268 (28%) 配列番号９６［ＴＭ１；２２−４４（Ｐ）、ＴＭ２；１
１３−１３５（Ｐ）、ＴＭ３；１５９−１８１（Ｐ）、
ＴＭ４；２０３−２２５（Ｓ）、ＴＭ５；２２８−２５
０（Ｐ）、ＴＭ６；２７２−２９４（Ｓ）］ Frizzled-10(AB027464)；23/96 (23%) 配列番号９８［ＴＭ１；１１−３３（Ｓ）、ＴＭ２；４
１−６３（Ｓ）、ＴＭ３；７１−９３（Ｓ）、ＴＭ４；
９６−１１８（Ｐ）、ＴＭ５；１２２−１４４（Ｓ）、
ＴＭ６；１４６−１６５（Ｓ）］ beta3-adrenergic receptor(AF109930)；39/120 (32%) 配列番号１００［ＴＭ１；８−２９（Ｐ）、ＴＭ２；３
１−５２（Ｐ）、ＴＭ３；５５−７３（Ｐ）、ＴＭ４；
７９−１００（Ｐ）、ＴＭ５；１１０−１３２（Ｓ）、
ＴＭ６；１４７−１６９（Ｐ）、ＴＭ７；１７７−１９
９（Ｐ）、ＴＭ８；２０１−２２２（Ｐ）］ putative pheromone receptor V2R1(AF053985)；51/219
(23%)
【００５２】配列番号１０２［ＴＭ１；６−２８
（Ｐ）、ＴＭ２；６０−８２（Ｓ）、ＴＭ３；９０−１
１１（Ｓ）、ＴＭ４；１２７−１４９（Ｐ）、ＴＭ５；
１８１−２０３（Ｓ）、ＴＭ６；２３７−２５９
（Ｐ）］ pheromone receptor VN6(U36898)；79/236 (33%) 配列番号１０４［ＴＭ１；５−２７（Ｓ）、ＴＭ２；４
１−６３（Ｐ）、ＴＭ３；８２−１０４（Ｓ）、ＴＭ
４；１０６−１２８（Ｐ）、ＴＭ５；１５３−１７５
（Ｓ）、ＴＭ６；１９１−２１３（Ｐ）、ＴＭ７；２３
５−２５７（Ｐ）、ＴＭ８；２８９−３１１（Ｓ）］ odorant receptor S19(AF121976)；106/228 (46%) 配列番号１０６［ＴＭ１；１−２３（Ｓ）、ＴＭ２；４
４−６６（Ｓ）、ＴＭ３；８５−１０６（Ｐ）、ＴＭ
４；１４９−１７１（Ｐ）、ＴＭ５；１８３−２０５
（Ｓ）、ＴＭ６；２１７−２３８（Ｓ）］ odorant receptor S18(AF121975)；159/222 (71%) 配列番号１０８［ＴＭ１；３−２５（Ｐ）、ＴＭ２；９
６−１１８（Ｓ）、ＴＭ３；１２０−１４２（Ｓ）、Ｔ
Ｍ４；１４９−１７１（Ｐ）、ＴＭ５；１８２−２０４
（Ｐ）、ＴＭ６；２１１−２３１（Ｐ）］ odorant receptor A16(AB030896)；122/244 (50%) 配列番号１１０［ＴＭ１；３１−５３（Ｐ）、ＴＭ２；
６４−８６（Ｓ）、ＴＭ３；１００−１２２（Ｓ）、Ｔ
Ｍ４；１３８−１６０（Ｐ）、ＴＭ５；１７１−１９３
（Ｓ）、ＴＭ６；１９９−２２１（Ｐ）］ olfactory receptor-like protein COR3'beta(L1743
2)；106/217 (48%)
（Ｐ）、ＴＭ２；６０−８２（Ｓ）、ＴＭ３；９０−１
１１（Ｓ）、ＴＭ４；１２７−１４９（Ｐ）、ＴＭ５；
１８１−２０３（Ｓ）、ＴＭ６；２３７−２５９
（Ｐ）］ pheromone receptor VN6(U36898)；79/236 (33%) 配列番号１０４［ＴＭ１；５−２７（Ｓ）、ＴＭ２；４
１−６３（Ｐ）、ＴＭ３；８２−１０４（Ｓ）、ＴＭ
４；１０６−１２８（Ｐ）、ＴＭ５；１５３−１７５
（Ｓ）、ＴＭ６；１９１−２１３（Ｐ）、ＴＭ７；２３
５−２５７（Ｐ）、ＴＭ８；２８９−３１１（Ｓ）］ odorant receptor S19(AF121976)；106/228 (46%) 配列番号１０６［ＴＭ１；１−２３（Ｓ）、ＴＭ２；４
４−６６（Ｓ）、ＴＭ３；８５−１０６（Ｐ）、ＴＭ
４；１４９−１７１（Ｐ）、ＴＭ５；１８３−２０５
（Ｓ）、ＴＭ６；２１７−２３８（Ｓ）］ odorant receptor S18(AF121975)；159/222 (71%) 配列番号１０８［ＴＭ１；３−２５（Ｐ）、ＴＭ２；９
６−１１８（Ｓ）、ＴＭ３；１２０−１４２（Ｓ）、Ｔ
Ｍ４；１４９−１７１（Ｐ）、ＴＭ５；１８２−２０４
（Ｐ）、ＴＭ６；２１１−２３１（Ｐ）］ odorant receptor A16(AB030896)；122/244 (50%) 配列番号１１０［ＴＭ１；３１−５３（Ｐ）、ＴＭ２；
６４−８６（Ｓ）、ＴＭ３；１００−１２２（Ｓ）、Ｔ
Ｍ４；１３８−１６０（Ｐ）、ＴＭ５；１７１−１９３
（Ｓ）、ＴＭ６；１９９−２２１（Ｐ）］ olfactory receptor-like protein COR3'beta(L1743
2)；106/217 (48%)
【００５３】配列番号１１２［ＴＭ１；３０−５２
（Ｐ）、ＴＭ２；６５−８７（Ｐ）、ＴＭ３；１０５−
１２７（Ｓ）、ＴＭ４；１３４−１５６（Ｓ）、ＴＭ
５；２０３−２２５（Ｐ）、ＴＭ６；２４３−２６５
（Ｐ）、ＴＭ７；２７２−２９４（Ｓ）］ odorant receptor S18(AF121975)；184/303 (60%) 配列番号１１４［ＴＭ１；２９−５１（Ｐ）、ＴＭ２；
５９−８１（Ｓ）、ＴＭ３；９９−１２１（Ｓ）、ＴＭ
４；１４４−１６６（Ｐ）、ＴＭ５；１７９−２０１
（Ｓ）、ＴＭ６；２０４−２２５（Ｐ）、ＴＭ７；２４
２−２６４（Ｐ）、ＴＭ８；２６９−２９１（Ｓ）］ odorant receptor MOR83(AB030894)；155/306 (50%) 配列番号１１６［ＴＭ１；４−２６（Ｓ）、ＴＭ２；３
２−５３（Ｐ）、ＴＭ３；６５−８７（Ｐ）、ＴＭ４；
９９−１２１（Ｓ）、ＴＭ５；１２３−１４４（Ｐ）、
ＴＭ６；１６２−１８４（Ｓ）、ＴＭ７；１８９−２１
１（Ｐ）］ odorant receptor MOR83(AB030894)；121/226 (53%) 配列番号１１８［ＴＭ１；２６−４８（Ｐ）、ＴＭ２；
６１−８３（Ｓ）、ＴＭ３；９８−１２０（Ｓ）、ＴＭ
４；１４１−１６３（Ｓ）、ＴＭ５；２０４−２２５
（Ｐ）、ＴＭ６；２３９−２６１（Ｐ）］ odorant receptor MOR83(AB030894)；156/303 (51%) 配列番号１２０［ＴＭ１；２５−４７（Ｐ）、ＴＭ２；
５７−７９（Ｓ）、ＴＭ３；８８−１０９（Ｓ）、ＴＭ
４；１３１−１５３（Ｐ）、ＴＭ５；２０１−２２３
（Ｐ）、ＴＭ６；２４２−２６４（Ｓ）］ CfOLF1(U53679)；107/235 (45%)
（Ｐ）、ＴＭ２；６５−８７（Ｐ）、ＴＭ３；１０５−
１２７（Ｓ）、ＴＭ４；１３４−１５６（Ｓ）、ＴＭ
５；２０３−２２５（Ｐ）、ＴＭ６；２４３−２６５
（Ｐ）、ＴＭ７；２７２−２９４（Ｓ）］ odorant receptor S18(AF121975)；184/303 (60%) 配列番号１１４［ＴＭ１；２９−５１（Ｐ）、ＴＭ２；
５９−８１（Ｓ）、ＴＭ３；９９−１２１（Ｓ）、ＴＭ
４；１４４−１６６（Ｐ）、ＴＭ５；１７９−２０１
（Ｓ）、ＴＭ６；２０４−２２５（Ｐ）、ＴＭ７；２４
２−２６４（Ｐ）、ＴＭ８；２６９−２９１（Ｓ）］ odorant receptor MOR83(AB030894)；155/306 (50%) 配列番号１１６［ＴＭ１；４−２６（Ｓ）、ＴＭ２；３
２−５３（Ｐ）、ＴＭ３；６５−８７（Ｐ）、ＴＭ４；
９９−１２１（Ｓ）、ＴＭ５；１２３−１４４（Ｐ）、
ＴＭ６；１６２−１８４（Ｓ）、ＴＭ７；１８９−２１
１（Ｐ）］ odorant receptor MOR83(AB030894)；121/226 (53%) 配列番号１１８［ＴＭ１；２６−４８（Ｐ）、ＴＭ２；
６１−８３（Ｓ）、ＴＭ３；９８−１２０（Ｓ）、ＴＭ
４；１４１−１６３（Ｓ）、ＴＭ５；２０４−２２５
（Ｐ）、ＴＭ６；２３９−２６１（Ｐ）］ odorant receptor MOR83(AB030894)；156/303 (51%) 配列番号１２０［ＴＭ１；２５−４７（Ｐ）、ＴＭ２；
５７−７９（Ｓ）、ＴＭ３；８８−１０９（Ｓ）、ＴＭ
４；１３１−１５３（Ｐ）、ＴＭ５；２０１−２２３
（Ｐ）、ＴＭ６；２４２−２６４（Ｓ）］ CfOLF1(U53679)；107/235 (45%)
【００５４】配列番号１２２［ＴＭ１；２９−５１
（Ｓ）、ＴＭ２；８３−１０５（Ｐ）、ＴＭ３；１１４
−１３６（Ｐ）、ＴＭ４；１４９−１７１（Ｓ）、ＴＭ
５；１９２−２１４（Ｓ）、ＴＭ６；２５９−２８１
（Ｐ）、ＴＭ７；２９４−３１６（Ｐ）］ odorant receptor S51(AF121981)；127/159 (79%) 配列番号１２４［ＴＭ１；３５−５７（Ｐ）、ＴＭ２；
６８−９０（Ｐ）、ＴＭ３；９６−１１８（Ｓ）、ＴＭ
４；１４７−１６９（Ｓ）、ＴＭ５；２１０−２３２
（Ｐ）、ＴＭ６；２４６−２６８（Ｐ）、ＴＭ７；２７
８−３００（Ｓ）］MOR 3'Beta1(AF133300)；119/308
(38%) 配列番号１２６［ＴＭ１；１５−３７（Ｓ）、ＴＭ２；
６４−８６（Ｐ）、ＴＭ３；９３−１１５（Ｓ）、ＴＭ
４；１４１−１６３（Ｓ）、ＴＭ５；２０６−２２８
（Ｐ）、ＴＭ６；２３７−２５９（Ｐ）］ odorant receptor S51(AF121981)；85/128 (66%) 配列番号１２８［ＴＭ１；６−２８（Ｓ）、ＴＭ２；３
２−５３（Ｐ）、ＴＭ３；５９−８１（Ｓ）、ＴＭ４；
９７−１１９（Ｓ）、ＴＭ５；１４５−１６７（Ｐ）、
ＴＭ６；２０５−２２６（Ｐ）、ＴＭ７；２３６−２５
８（Ｐ）、ＴＭ８；２６８−２９０（Ｓ）］ similar to rat olfactory receptor OR18(AC004908)；
209/311 (67%) 配列番号１３０［ＴＭ１；１−２３（Ｓ）、ＴＭ２；２
８−５０（Ｐ）、ＴＭ３；６３−８５（Ｓ）、ＴＭ４；
１４２−１６３（Ｐ）、ＴＭ５；２０３−２２５
（Ｐ）、ＴＭ６；２３８−２６０（Ｐ）、ＴＭ７；２７
１−２９３（Ｐ）］ olfactory receptor-like protein COR3'beta(L1743
2)；147/299 (49%)
（Ｓ）、ＴＭ２；８３−１０５（Ｐ）、ＴＭ３；１１４
−１３６（Ｐ）、ＴＭ４；１４９−１７１（Ｓ）、ＴＭ
５；１９２−２１４（Ｓ）、ＴＭ６；２５９−２８１
（Ｐ）、ＴＭ７；２９４−３１６（Ｐ）］ odorant receptor S51(AF121981)；127/159 (79%) 配列番号１２４［ＴＭ１；３５−５７（Ｐ）、ＴＭ２；
６８−９０（Ｐ）、ＴＭ３；９６−１１８（Ｓ）、ＴＭ
４；１４７−１６９（Ｓ）、ＴＭ５；２１０−２３２
（Ｐ）、ＴＭ６；２４６−２６８（Ｐ）、ＴＭ７；２７
８−３００（Ｓ）］MOR 3'Beta1(AF133300)；119/308
(38%) 配列番号１２６［ＴＭ１；１５−３７（Ｓ）、ＴＭ２；
６４−８６（Ｐ）、ＴＭ３；９３−１１５（Ｓ）、ＴＭ
４；１４１−１６３（Ｓ）、ＴＭ５；２０６−２２８
（Ｐ）、ＴＭ６；２３７−２５９（Ｐ）］ odorant receptor S51(AF121981)；85/128 (66%) 配列番号１２８［ＴＭ１；６−２８（Ｓ）、ＴＭ２；３
２−５３（Ｐ）、ＴＭ３；５９−８１（Ｓ）、ＴＭ４；
９７−１１９（Ｓ）、ＴＭ５；１４５−１６７（Ｐ）、
ＴＭ６；２０５−２２６（Ｐ）、ＴＭ７；２３６−２５
８（Ｐ）、ＴＭ８；２６８−２９０（Ｓ）］ similar to rat olfactory receptor OR18(AC004908)；
209/311 (67%) 配列番号１３０［ＴＭ１；１−２３（Ｓ）、ＴＭ２；２
８−５０（Ｐ）、ＴＭ３；６３−８５（Ｓ）、ＴＭ４；
１４２−１６３（Ｐ）、ＴＭ５；２０３−２２５
（Ｐ）、ＴＭ６；２３８−２６０（Ｐ）、ＴＭ７；２７
１−２９３（Ｐ）］ olfactory receptor-like protein COR3'beta(L1743
2)；147/299 (49%)
【００５５】配列番号１３２［ＴＭ１；３１−５３
（Ｓ）、ＴＭ２；６３−８５（Ｓ）、ＴＭ３；９９−１
２１（Ｓ）、ＴＭ４；１４９−１７１（Ｐ）、ＴＭ５；
２０５−２２７（Ｐ）、ＴＭ６；２４４−２６６
（Ｓ）、ＴＭ７；２７３−２９５（Ｐ）］ putative G-protein coupled receptor RA1c(AF07986
4)；142/299 (47%) 配列番号１３４［ＴＭ１；１−２３（Ｓ）、ＴＭ２；２
６−４８（Ｓ）、ＴＭ３；５１−７３（Ｓ）、ＴＭ４；
８５−１０７（Ｓ）、ＴＭ５；１５１−１７２（Ｐ）、
ＴＭ６；１８２−２０４（Ｐ）、ＴＭ７；２１２−２３
４（Ｓ）］ odorant receptor S19(AF121976)；142/246 (57%) 配列番号１３６［ＴＭ１；１１−３３（Ｓ）、ＴＭ２；
３７−５９（Ｐ）、ＴＭ３；７１−９３（Ｐ）、ＴＭ
４；１０７−１２９（Ｐ）、ＴＭ５；１５１−１７３
（Ｓ）、ＴＭ６；２０７−２２９（Ｐ）、ＴＭ７；２４
９−２７１（Ｐ）］ olfactory receptor-like protein COR3'beta(L1743
2)；134/306 (43%) 配列番号１３８［ＴＭ１；１１−３２（Ｓ）、ＴＭ２；
４９−７１（Ｓ）、ＴＭ３；９１−１１３（Ｐ）、ＴＭ
４；１２８−１５０（Ｓ）、ＴＭ５；１７０−１９２
（Ｐ）、ＴＭ６；２３１−２５３（Ｐ）、ＴＭ７；２６
８−２９０（Ｓ）、ＴＭ８；３１２−３３４（Ｓ）］ olfactory receptor-like protein COR3'beta(L1743
2)；149/313 (47%) 配列番号１４０［ＴＭ１；１−２３（Ｓ）、ＴＭ２；３
０−５２（Ｐ）、ＴＭ３；６７−８９（Ｓ）、ＴＭ４；
１０２−１２４（Ｓ）、ＴＭ５；１３７−１５９
（Ｓ）、ＴＭ６；２０２−２２４（Ｐ）、ＴＭ７；２３
９−２６１（Ｐ）、ＴＭ８；２７１−２９３（Ｐ）］ olfactory receptor-like protein COR3'beta(L1743
2)；156/298 (52%)
（Ｓ）、ＴＭ２；６３−８５（Ｓ）、ＴＭ３；９９−１
２１（Ｓ）、ＴＭ４；１４９−１７１（Ｐ）、ＴＭ５；
２０５−２２７（Ｐ）、ＴＭ６；２４４−２６６
（Ｓ）、ＴＭ７；２７３−２９５（Ｐ）］ putative G-protein coupled receptor RA1c(AF07986
4)；142/299 (47%) 配列番号１３４［ＴＭ１；１−２３（Ｓ）、ＴＭ２；２
６−４８（Ｓ）、ＴＭ３；５１−７３（Ｓ）、ＴＭ４；
８５−１０７（Ｓ）、ＴＭ５；１５１−１７２（Ｐ）、
ＴＭ６；１８２−２０４（Ｐ）、ＴＭ７；２１２−２３
４（Ｓ）］ odorant receptor S19(AF121976)；142/246 (57%) 配列番号１３６［ＴＭ１；１１−３３（Ｓ）、ＴＭ２；
３７−５９（Ｐ）、ＴＭ３；７１−９３（Ｐ）、ＴＭ
４；１０７−１２９（Ｐ）、ＴＭ５；１５１−１７３
（Ｓ）、ＴＭ６；２０７−２２９（Ｐ）、ＴＭ７；２４
９−２７１（Ｐ）］ olfactory receptor-like protein COR3'beta(L1743
2)；134/306 (43%) 配列番号１３８［ＴＭ１；１１−３２（Ｓ）、ＴＭ２；
４９−７１（Ｓ）、ＴＭ３；９１−１１３（Ｐ）、ＴＭ
４；１２８−１５０（Ｓ）、ＴＭ５；１７０−１９２
（Ｐ）、ＴＭ６；２３１−２５３（Ｐ）、ＴＭ７；２６
８−２９０（Ｓ）、ＴＭ８；３１２−３３４（Ｓ）］ olfactory receptor-like protein COR3'beta(L1743
2)；149/313 (47%) 配列番号１４０［ＴＭ１；１−２３（Ｓ）、ＴＭ２；３
０−５２（Ｐ）、ＴＭ３；６７−８９（Ｓ）、ＴＭ４；
１０２−１２４（Ｓ）、ＴＭ５；１３７−１５９
（Ｓ）、ＴＭ６；２０２−２２４（Ｐ）、ＴＭ７；２３
９−２６１（Ｐ）、ＴＭ８；２７１−２９３（Ｐ）］ olfactory receptor-like protein COR3'beta(L1743
2)；156/298 (52%)
【００５６】配列番号１４２［ＴＭ１；２−２４
（Ｓ）、ＴＭ２；３３−５５（Ｐ）、ＴＭ３；６９−９
１（Ｐ）、ＴＭ４；１０６−１２８（Ｓ）、ＴＭ５；１
４２−１６４（Ｓ）、ＴＭ６；２０８−２３０（Ｐ）、
ＴＭ７；２４４−２６６（Ｓ）、ＴＭ８；２７６−２９
８（Ｓ）］ putative G-protein coupled receptor RA1c(AF07986
4)；171/305 (56%) 配列番号１４４［ＴＭ１；３１−５３（Ｐ）、ＴＭ２；
６５−８７（Ｐ）、ＴＭ３；１４１−１６３（Ｓ）、Ｔ
Ｍ４；１８３−２０５（Ｐ）、ＴＭ５；２１２−２３４
（Ｐ）、ＴＭ６；２４０−２６２（Ｐ）、ＴＭ７；２７
３−２９５（Ｓ）］ olfactory receptor 64(AF071080)；161/302 (53%) 配列番号１４６［ＴＭ１；６−２８（Ｐ）、ＴＭ２；４
２−６４（Ｓ）、ＴＭ３；８７−１０９（Ｐ）、ＴＭ
４；１４４−１６６（Ｐ）、ＴＭ５；１８３−２０５
（Ｐ）、ＴＭ６；２１７−２３７（Ｓ）］ olfactory receptor-like protein COR3'beta(L1743
2)；129/249 (51%) 配列番号１４８［ＴＭ１；１−１８（Ｐ）、ＴＭ２；４
３−６５（Ｓ）、ＴＭ３；６７−８８（Ｓ）、ＴＭ４；
９９−１２１（Ｓ）、ＴＭ５；１３６−１５８（Ｓ）、
ＴＭ６；１７５−１９７（Ｐ）］ putative G-protein coupled receptor RA1c(AF07986
4)；73/151 (48%) 配列番号１５０［ＴＭ１；３１−５３（Ｐ）、ＴＭ２；
６６−８８（Ｐ）、ＴＭ３；１０４−１２６（Ｓ）、Ｔ
Ｍ４；１４１−１６３（Ｓ）、ＴＭ５；２０５−２２７
（Ｐ）、ＴＭ６；２４６−２６８（Ｓ）、ＴＭ７；２７
４−２９６（Ｓ）］ odorant receptor S18(AF121975)；142/308 (46%)
（Ｓ）、ＴＭ２；３３−５５（Ｐ）、ＴＭ３；６９−９
１（Ｐ）、ＴＭ４；１０６−１２８（Ｓ）、ＴＭ５；１
４２−１６４（Ｓ）、ＴＭ６；２０８−２３０（Ｐ）、
ＴＭ７；２４４−２６６（Ｓ）、ＴＭ８；２７６−２９
８（Ｓ）］ putative G-protein coupled receptor RA1c(AF07986
4)；171/305 (56%) 配列番号１４４［ＴＭ１；３１−５３（Ｐ）、ＴＭ２；
６５−８７（Ｐ）、ＴＭ３；１４１−１６３（Ｓ）、Ｔ
Ｍ４；１８３−２０５（Ｐ）、ＴＭ５；２１２−２３４
（Ｐ）、ＴＭ６；２４０−２６２（Ｐ）、ＴＭ７；２７
３−２９５（Ｓ）］ olfactory receptor 64(AF071080)；161/302 (53%) 配列番号１４６［ＴＭ１；６−２８（Ｐ）、ＴＭ２；４
２−６４（Ｓ）、ＴＭ３；８７−１０９（Ｐ）、ＴＭ
４；１４４−１６６（Ｐ）、ＴＭ５；１８３−２０５
（Ｐ）、ＴＭ６；２１７−２３７（Ｓ）］ olfactory receptor-like protein COR3'beta(L1743
2)；129/249 (51%) 配列番号１４８［ＴＭ１；１−１８（Ｐ）、ＴＭ２；４
３−６５（Ｓ）、ＴＭ３；６７−８８（Ｓ）、ＴＭ４；
９９−１２１（Ｓ）、ＴＭ５；１３６−１５８（Ｓ）、
ＴＭ６；１７５−１９７（Ｐ）］ putative G-protein coupled receptor RA1c(AF07986
4)；73/151 (48%) 配列番号１５０［ＴＭ１；３１−５３（Ｐ）、ＴＭ２；
６６−８８（Ｐ）、ＴＭ３；１０４−１２６（Ｓ）、Ｔ
Ｍ４；１４１−１６３（Ｓ）、ＴＭ５；２０５−２２７
（Ｐ）、ＴＭ６；２４６−２６８（Ｓ）、ＴＭ７；２７
４−２９６（Ｓ）］ odorant receptor S18(AF121975)；142/308 (46%)
【００５７】配列番号１５２［ＴＭ１；６−２６
（Ｓ）、ＴＭ２；２９−５１（Ｐ）、ＴＭ３；５３−７
５（Ｐ）、ＴＭ４；９７−１１９（Ｓ）、ＴＭ５；１３
３−１５５（Ｓ）、ＴＭ６；２０２−２２４（Ｐ）、Ｔ
Ｍ７；２３７−２５９（Ｐ）、ＴＭ８；２６９−２９１
（Ｓ）］ putative G-protein coupled receptor RA1c(AF07986
4)；298/318 (93%) 配列番号１５４［ＴＭ１；１−２３（Ｓ）、ＴＭ２；２
９−５１（Ｐ）、ＴＭ３；６７−８９（Ｐ）、ＴＭ４；
１０４−１２６（Ｓ）、ＴＭ５；１４５−１６６
（Ｓ）、ＴＭ６；２０６−２２８（Ｐ）、ＴＭ７；２４
４−２６６（Ｓ）、ＴＭ８；２７７−２９８（Ｓ）］ putative G-protein coupled receptor RA1c(AF07986
4)；157/301 (52%) 配列番号１５６［ＴＭ１；１８−４０（Ｐ）、ＴＭ２；
４４−６５（Ｐ）、ＴＭ３；６９−９１（Ｓ）、ＴＭ
４；１１５−１３７（Ｐ）、ＴＭ５；１５４−１７６
（Ｐ）、ＴＭ６；２１４−２３６（Ｐ）、ＴＭ７；２５
５−２７７（Ｐ）、ＴＭ８；２８２−３０４（Ｓ）］ putative G-protein coupled receptor RA1c(AF07986
4)；184/307 (59%) 配列番号１５８［ＴＭ１；３０−５２（Ｐ）、ＴＭ２；
５８−８０（Ｓ）、ＴＭ３；８３−１０５（Ｓ）、ＴＭ
４；２０４−２２６（Ｐ）、ＴＭ５；２４０−２６２
（Ｐ）、ＴＭ６；２７４−２９６（Ｓ）］ putative G-protein coupled receptor RA1c(AF07986
4)；180/299 (60%) 配列番号１６０［ＴＭ１；２−２４（Ｓ）、ＴＭ２；３
０−５２（Ｐ）、ＴＭ３；６４−８６（Ｓ）、ＴＭ４；
１００−１２２（Ｓ）、ＴＭ５；１４１−１６３
（Ｓ）、ＴＭ６；２０４−２２６（Ｐ）、ＴＭ７；２７
３−２９５（Ｓ）］ odorant receptor S18(AF121975)；164/303 (54%)
（Ｓ）、ＴＭ２；２９−５１（Ｐ）、ＴＭ３；５３−７
５（Ｐ）、ＴＭ４；９７−１１９（Ｓ）、ＴＭ５；１３
３−１５５（Ｓ）、ＴＭ６；２０２−２２４（Ｐ）、Ｔ
Ｍ７；２３７−２５９（Ｐ）、ＴＭ８；２６９−２９１
（Ｓ）］ putative G-protein coupled receptor RA1c(AF07986
4)；298/318 (93%) 配列番号１５４［ＴＭ１；１−２３（Ｓ）、ＴＭ２；２
９−５１（Ｐ）、ＴＭ３；６７−８９（Ｐ）、ＴＭ４；
１０４−１２６（Ｓ）、ＴＭ５；１４５−１６６
（Ｓ）、ＴＭ６；２０６−２２８（Ｐ）、ＴＭ７；２４
４−２６６（Ｓ）、ＴＭ８；２７７−２９８（Ｓ）］ putative G-protein coupled receptor RA1c(AF07986
4)；157/301 (52%) 配列番号１５６［ＴＭ１；１８−４０（Ｐ）、ＴＭ２；
４４−６５（Ｐ）、ＴＭ３；６９−９１（Ｓ）、ＴＭ
４；１１５−１３７（Ｐ）、ＴＭ５；１５４−１７６
（Ｐ）、ＴＭ６；２１４−２３６（Ｐ）、ＴＭ７；２５
５−２７７（Ｐ）、ＴＭ８；２８２−３０４（Ｓ）］ putative G-protein coupled receptor RA1c(AF07986
4)；184/307 (59%) 配列番号１５８［ＴＭ１；３０−５２（Ｐ）、ＴＭ２；
５８−８０（Ｓ）、ＴＭ３；８３−１０５（Ｓ）、ＴＭ
４；２０４−２２６（Ｐ）、ＴＭ５；２４０−２６２
（Ｐ）、ＴＭ６；２７４−２９６（Ｓ）］ putative G-protein coupled receptor RA1c(AF07986
4)；180/299 (60%) 配列番号１６０［ＴＭ１；２−２４（Ｓ）、ＴＭ２；３
０−５２（Ｐ）、ＴＭ３；６４−８６（Ｓ）、ＴＭ４；
１００−１２２（Ｓ）、ＴＭ５；１４１−１６３
（Ｓ）、ＴＭ６；２０４−２２６（Ｐ）、ＴＭ７；２７
３−２９５（Ｓ）］ odorant receptor S18(AF121975)；164/303 (54%)
【００５８】配列番号１６２［ＴＭ１；３０−５２
（Ｐ）、ＴＭ２；６４−８６（Ｐ）、ＴＭ３；１０２−
１２４（Ｓ）、ＴＭ４；１４２−１６４（Ｓ）、ＴＭ
５；２０５−２２７（Ｐ）、ＴＭ６；２４１−２６３
（Ｓ）、ＴＭ７；２７３−２９５（Ｓ）］ odorant receptor S18(AF121975)；166/305 (54%) 配列番号１６４［ＴＭ１；３３−５５（Ｐ）、ＴＭ２；
６７−８９（Ｐ）、ＴＭ３；１０４−１２６（Ｓ）、Ｔ
Ｍ４；１４６−１６８（Ｐ）、ＴＭ５；２１４−２３６
（Ｓ）、ＴＭ６；２４６−２６８（Ｐ）、ＴＭ７；２７
６−２９８（Ｓ）］ odorant receptor S19(AF121976)；140/304 (46%) 配列番号１６６［ＴＭ１；１４−３６（Ｓ）、ＴＭ２；
４２−６４（Ｐ）、ＴＭ３；７８−１００（Ｓ）、ＴＭ
４；１１５−１３７（Ｐ）、ＴＭ５；１５３−１７４
（Ｓ）、ＴＭ６；２１７−２３９（Ｐ）］ odorant receptor S18(AF121975)；209/248 (84%) 配列番号１６８［ＴＭ１；３６−５８（Ｐ）、ＴＭ２；
６８−９０（Ｐ）、ＴＭ３；１０３−１２５（Ｐ）、Ｔ
Ｍ４；１４６−１６８（Ｓ）、ＴＭ５；２０８−２３０
（Ｐ）、ＴＭ６；２４５−２６７（Ｐ）、ＴＭ７；２７
５−２９７（Ｓ）］ odorant receptor S18(AF121975)；123/298 (41%) 配列番号１７０［ＴＭ１；３１−５３（Ｓ）、ＴＭ２；
６３−８５（Ｐ）、ＴＭ３；１００−１２２（Ｓ）、Ｔ
Ｍ４；１４０−１６２（Ｓ）、ＴＭ５；２０４−２２６
（Ｐ）、ＴＭ６；２３９−２６０（Ｐ）］ MOR 3'Beta1(AF133300)；103/259 (39%)
（Ｐ）、ＴＭ２；６４−８６（Ｐ）、ＴＭ３；１０２−
１２４（Ｓ）、ＴＭ４；１４２−１６４（Ｓ）、ＴＭ
５；２０５−２２７（Ｐ）、ＴＭ６；２４１−２６３
（Ｓ）、ＴＭ７；２７３−２９５（Ｓ）］ odorant receptor S18(AF121975)；166/305 (54%) 配列番号１６４［ＴＭ１；３３−５５（Ｐ）、ＴＭ２；
６７−８９（Ｐ）、ＴＭ３；１０４−１２６（Ｓ）、Ｔ
Ｍ４；１４６−１６８（Ｐ）、ＴＭ５；２１４−２３６
（Ｓ）、ＴＭ６；２４６−２６８（Ｐ）、ＴＭ７；２７
６−２９８（Ｓ）］ odorant receptor S19(AF121976)；140/304 (46%) 配列番号１６６［ＴＭ１；１４−３６（Ｓ）、ＴＭ２；
４２−６４（Ｐ）、ＴＭ３；７８−１００（Ｓ）、ＴＭ
４；１１５−１３７（Ｐ）、ＴＭ５；１５３−１７４
（Ｓ）、ＴＭ６；２１７−２３９（Ｐ）］ odorant receptor S18(AF121975)；209/248 (84%) 配列番号１６８［ＴＭ１；３６−５８（Ｐ）、ＴＭ２；
６８−９０（Ｐ）、ＴＭ３；１０３−１２５（Ｐ）、Ｔ
Ｍ４；１４６−１６８（Ｓ）、ＴＭ５；２０８−２３０
（Ｐ）、ＴＭ６；２４５−２６７（Ｐ）、ＴＭ７；２７
５−２９７（Ｓ）］ odorant receptor S18(AF121975)；123/298 (41%) 配列番号１７０［ＴＭ１；３１−５３（Ｓ）、ＴＭ２；
６３−８５（Ｐ）、ＴＭ３；１００−１２２（Ｓ）、Ｔ
Ｍ４；１４０−１６２（Ｓ）、ＴＭ５；２０４−２２６
（Ｐ）、ＴＭ６；２３９−２６０（Ｐ）］ MOR 3'Beta1(AF133300)；103/259 (39%)
【００５９】配列番号１７２［ＴＭ１；２９−５１
（Ｐ）、ＴＭ２；６３−８５（Ｐ）、ＴＭ３；９９−１
２１（Ｓ）、ＴＭ４；１４３−１６５（Ｓ）、ＴＭ５；
１７７−１９９（Ｓ）、ＴＭ６；２０４−２２６
（Ｓ）］ putative G-protein coupled receptor RA1c(AF07986
4)；112/247 (45%), 配列番号１７４［ＴＭ１；１０−３２（Ｐ）、ＴＭ２；
４４−６６（Ｐ）、ＴＭ３；７３−９３（Ｓ）、ＴＭ
４；１２８−１５０（Ｓ）、ＴＭ５；１５８−１７９
（Ｓ）、ＴＭ６；１８１−２０３（Ｐ）］ olfactory receptor(AF179805)；27/101 (26%) 配列番号１７６［ＴＭ１；５−２７（Ｐ）、ＴＭ２；４
６−６８（Ｓ）、ＴＭ３；８５−１０７（Ｓ）、ＴＭ
４；１２３−１４５（Ｓ）、ＴＭ５；１５４−１７６
（Ｐ）、ＴＭ６；１８２−２０４（Ｓ）、ＴＭ７；２１
６−２３７（Ｓ）］ odorant receptor S18(AF121975)；149/250 (59%) 配列番号１７８［ＴＭ１；１−２３（Ｓ）、ＴＭ２；２
８−５０（Ｓ）、ＴＭ３；９６−１１８（Ｓ）、ＴＭ
４；１３４−１５６（Ｓ）、ＴＭ５；１９６−２１８
（Ｐ）、ＴＭ６；２３８−２６０（Ｐ）、ＴＭ７；２６
９−２９１（Ｓ）］ putative G-protein coupled receptor RA1c(AF07986
4)；172/307 (56%) 配列番号１８０［ＴＭ１；６−２８（Ｓ）、ＴＭ２；４
０−６２（Ｐ）、ＴＭ３；７２−９４（Ｓ）、ＴＭ４；
１１１−１３３（Ｓ）、ＴＭ５；１５８−１８０
（Ｐ）、ＴＭ６；２１４−２３６（Ｐ）、ＴＭ７；２５
２−２７４（Ｐ）、ＴＭ８；２８３−３０５（Ｓ）］ olfactory receptor-like protein COR3'beta(L1743
2)；167/304 (54%)
（Ｐ）、ＴＭ２；６３−８５（Ｐ）、ＴＭ３；９９−１
２１（Ｓ）、ＴＭ４；１４３−１６５（Ｓ）、ＴＭ５；
１７７−１９９（Ｓ）、ＴＭ６；２０４−２２６
（Ｓ）］ putative G-protein coupled receptor RA1c(AF07986
4)；112/247 (45%), 配列番号１７４［ＴＭ１；１０−３２（Ｐ）、ＴＭ２；
４４−６６（Ｐ）、ＴＭ３；７３−９３（Ｓ）、ＴＭ
４；１２８−１５０（Ｓ）、ＴＭ５；１５８−１７９
（Ｓ）、ＴＭ６；１８１−２０３（Ｐ）］ olfactory receptor(AF179805)；27/101 (26%) 配列番号１７６［ＴＭ１；５−２７（Ｐ）、ＴＭ２；４
６−６８（Ｓ）、ＴＭ３；８５−１０７（Ｓ）、ＴＭ
４；１２３−１４５（Ｓ）、ＴＭ５；１５４−１７６
（Ｐ）、ＴＭ６；１８２−２０４（Ｓ）、ＴＭ７；２１
６−２３７（Ｓ）］ odorant receptor S18(AF121975)；149/250 (59%) 配列番号１７８［ＴＭ１；１−２３（Ｓ）、ＴＭ２；２
８−５０（Ｓ）、ＴＭ３；９６−１１８（Ｓ）、ＴＭ
４；１３４−１５６（Ｓ）、ＴＭ５；１９６−２１８
（Ｐ）、ＴＭ６；２３８−２６０（Ｐ）、ＴＭ７；２６
９−２９１（Ｓ）］ putative G-protein coupled receptor RA1c(AF07986
4)；172/307 (56%) 配列番号１８０［ＴＭ１；６−２８（Ｓ）、ＴＭ２；４
０−６２（Ｐ）、ＴＭ３；７２−９４（Ｓ）、ＴＭ４；
１１１−１３３（Ｓ）、ＴＭ５；１５８−１８０
（Ｐ）、ＴＭ６；２１４−２３６（Ｐ）、ＴＭ７；２５
２−２７４（Ｐ）、ＴＭ８；２８３−３０５（Ｓ）］ olfactory receptor-like protein COR3'beta(L1743
2)；167/304 (54%)
【００６０】配列番号１８２［ＴＭ１；２９−５１
（Ｓ）、ＴＭ２；６５−８７（Ｓ）、ＴＭ３；１０８−
１３０（Ｓ）、ＴＭ４；１４４−１６５（Ｐ）、ＴＭ
５；２０１−２２３（Ｐ）、ＴＭ６；２４０−２６２
（Ｐ）、ＴＭ７；２７１−２９３（Ｓ）］ olfactory receptor-like protein COR3'beta(L1743
2)；153/296 (51%) 配列番号１８４［ＴＭ１；２−２４（Ｓ）、ＴＭ２；３
０−５２（Ｐ）、ＴＭ３；６４−８６（Ｓ）、ＴＭ４；
１０５−１２７（Ｓ）、ＴＭ５；２０４−２２６
（Ｐ）、ＴＭ６；２４０−２６２（Ｐ）、ＴＭ７；２７
４−２９６（Ｓ）］ olfactory receptor-like protein COR3'beta(L1743
2)；150/303 (49%) 配列番号１８６［ＴＭ１；４−２６（Ｓ）、ＴＭ２；３
５−５７（Ｐ）、ＴＭ３；７２−９４（Ｓ）、ＴＭ４；
１１５−１３７（Ｓ）、ＴＭ５；１５１−１７２
（Ｓ）、ＴＭ６；１９１−２１３（Ｐ）、ＴＭ７；２４
９−２７１（Ｓ）、ＴＭ８；２８１−３０３（Ｓ）］ MOR 3'Beta1(AF133300)；157/298 (52%) 配列番号１８８［ＴＭ１；３６−５８（Ｐ）、ＴＭ２；
７４−９６（Ｐ）、ＴＭ３；１０８−１３０（Ｐ）、Ｔ
Ｍ４；１４９−１７１（Ｓ）、ＴＭ５；２０９−２３１
（Ｐ）、ＴＭ６；２６０−２８２（Ｐ）］ MOR 3'Beta1(AF133300)；123/307 (40%) 配列番号１９０［ＴＭ１；３０−５２（Ｓ）、ＴＭ２；
６７−８９（Ｓ）、ＴＭ３；１０３−１２５（Ｓ）、Ｔ
Ｍ４；２０５−２２７（Ｐ）、ＴＭ５；２４２−２６４
（Ｓ）、ＴＭ６；２６９−２９１（Ｓ）］ MOR 3'Beta1(AF133300)；172/307 (56%)
（Ｓ）、ＴＭ２；６５−８７（Ｓ）、ＴＭ３；１０８−
１３０（Ｓ）、ＴＭ４；１４４−１６５（Ｐ）、ＴＭ
５；２０１−２２３（Ｐ）、ＴＭ６；２４０−２６２
（Ｐ）、ＴＭ７；２７１−２９３（Ｓ）］ olfactory receptor-like protein COR3'beta(L1743
2)；153/296 (51%) 配列番号１８４［ＴＭ１；２−２４（Ｓ）、ＴＭ２；３
０−５２（Ｐ）、ＴＭ３；６４−８６（Ｓ）、ＴＭ４；
１０５−１２７（Ｓ）、ＴＭ５；２０４−２２６
（Ｐ）、ＴＭ６；２４０−２６２（Ｐ）、ＴＭ７；２７
４−２９６（Ｓ）］ olfactory receptor-like protein COR3'beta(L1743
2)；150/303 (49%) 配列番号１８６［ＴＭ１；４−２６（Ｓ）、ＴＭ２；３
５−５７（Ｐ）、ＴＭ３；７２−９４（Ｓ）、ＴＭ４；
１１５−１３７（Ｓ）、ＴＭ５；１５１−１７２
（Ｓ）、ＴＭ６；１９１−２１３（Ｐ）、ＴＭ７；２４
９−２７１（Ｓ）、ＴＭ８；２８１−３０３（Ｓ）］ MOR 3'Beta1(AF133300)；157/298 (52%) 配列番号１８８［ＴＭ１；３６−５８（Ｐ）、ＴＭ２；
７４−９６（Ｐ）、ＴＭ３；１０８−１３０（Ｐ）、Ｔ
Ｍ４；１４９−１７１（Ｓ）、ＴＭ５；２０９−２３１
（Ｐ）、ＴＭ６；２６０−２８２（Ｐ）］ MOR 3'Beta1(AF133300)；123/307 (40%) 配列番号１９０［ＴＭ１；３０−５２（Ｓ）、ＴＭ２；
６７−８９（Ｓ）、ＴＭ３；１０３−１２５（Ｓ）、Ｔ
Ｍ４；２０５−２２７（Ｐ）、ＴＭ５；２４２−２６４
（Ｓ）、ＴＭ６；２６９−２９１（Ｓ）］ MOR 3'Beta1(AF133300)；172/307 (56%)
【００６１】配列番号１９２［ＴＭ１；３１−５３
（Ｐ）、ＴＭ２；５６−７８（Ｓ）、ＴＭ３；８１−１
０３（Ｓ）、ＴＭ４；１０７−１２９（Ｓ）、ＴＭ５；
１４５−１６７（Ｐ）、ＴＭ６；１８４−２０６
（Ｐ）］ putative G-protein coupled receptor RA1c(AF07986
4)；98/210 (46%) 配列番号１９４［ＴＭ１；３４−５６（Ｐ）、ＴＭ２；
７１−９３（Ｐ）、ＴＭ３；１０８−１３０（Ｓ）、Ｔ
Ｍ４；１４４−１６６（Ｐ）、ＴＭ５；１９１−２１２
（Ｐ）、ＴＭ６；２２４−２４６（Ｐ）、ＴＭ７；２５
１−２７３（Ｓ）］ odorant receptor 5.24(AF158963)；168/328 (51%) 配列番号１９６［ＴＭ１；８−３０（Ｓ）、ＴＭ２；５
３−７５（Ｐ）、ＴＭ３；１０５−１２７（Ｐ）、ＴＭ
４；１３９−１６１（Ｓ）、ＴＭ５；１６７−１８９
（Ｐ）、ＴＭ６；２００−２２２（Ｐ）、ＴＭ７；２３
１−２５３（Ｐ）］ olfactory receptor OR18(S29710)；189/268 (70%) 配列番号１９８［ＴＭ１；２８−５０（Ｐ）、ＴＭ２；
８４−１０６（Ｓ）、ＴＭ３；１１７−１３９（Ｓ）、
ＴＭ４；１４５−１６６（Ｓ）、ＴＭ５；１８５−２０
７（Ｐ）、ＴＭ６；２１３−２３５（Ｓ）、ＴＭ７；２
４３−２６５（Ｐ）、ＴＭ８；２７４−２９６（Ｓ）］ odorant receptor S19(AF121976)；192/299 (64%) 配列番号２００［ＴＭ１；７−２９（Ｓ）、ＴＭ２；３
５−５７（Ｓ）、ＴＭ３；６４−８６（Ｓ）、ＴＭ４；
９５−１１７（Ｓ）、ＴＭ５；１４１−１６３（Ｓ）、
ＴＭ６；２００−２２１（Ｐ）］ olfactory receptor 17-1(AF095725)；95/96 (98%)
（Ｐ）、ＴＭ２；５６−７８（Ｓ）、ＴＭ３；８１−１
０３（Ｓ）、ＴＭ４；１０７−１２９（Ｓ）、ＴＭ５；
１４５−１６７（Ｐ）、ＴＭ６；１８４−２０６
（Ｐ）］ putative G-protein coupled receptor RA1c(AF07986
4)；98/210 (46%) 配列番号１９４［ＴＭ１；３４−５６（Ｐ）、ＴＭ２；
７１−９３（Ｐ）、ＴＭ３；１０８−１３０（Ｓ）、Ｔ
Ｍ４；１４４−１６６（Ｐ）、ＴＭ５；１９１−２１２
（Ｐ）、ＴＭ６；２２４−２４６（Ｐ）、ＴＭ７；２５
１−２７３（Ｓ）］ odorant receptor 5.24(AF158963)；168/328 (51%) 配列番号１９６［ＴＭ１；８−３０（Ｓ）、ＴＭ２；５
３−７５（Ｐ）、ＴＭ３；１０５−１２７（Ｐ）、ＴＭ
４；１３９−１６１（Ｓ）、ＴＭ５；１６７−１８９
（Ｐ）、ＴＭ６；２００−２２２（Ｐ）、ＴＭ７；２３
１−２５３（Ｐ）］ olfactory receptor OR18(S29710)；189/268 (70%) 配列番号１９８［ＴＭ１；２８−５０（Ｐ）、ＴＭ２；
８４−１０６（Ｓ）、ＴＭ３；１１７−１３９（Ｓ）、
ＴＭ４；１４５−１６６（Ｓ）、ＴＭ５；１８５−２０
７（Ｐ）、ＴＭ６；２１３−２３５（Ｓ）、ＴＭ７；２
４３−２６５（Ｐ）、ＴＭ８；２７４−２９６（Ｓ）］ odorant receptor S19(AF121976)；192/299 (64%) 配列番号２００［ＴＭ１；７−２９（Ｓ）、ＴＭ２；３
５−５７（Ｓ）、ＴＭ３；６４−８６（Ｓ）、ＴＭ４；
９５−１１７（Ｓ）、ＴＭ５；１４１−１６３（Ｓ）、
ＴＭ６；２００−２２１（Ｐ）］ olfactory receptor 17-1(AF095725)；95/96 (98%)
【００６２】配列番号２０２［ＴＭ１；２６−４８
（Ｐ）、ＴＭ２；６２−８４（Ｓ）、ＴＭ３；９６−１
１８（Ｐ）、ＴＭ４；１４１−１６３（Ｓ）、ＴＭ５；
２０４−２２５（Ｐ）、ＴＭ６；２３９−２６１
（Ｐ）、ＴＭ７；２６８−２９０（Ｓ）］odorant rece
ptor MOR83(AB030894)；159/301 (52%) 配列番号２０４［ＴＭ１；３１−５３（Ｐ）、ＴＭ２；
６５−８７（Ｓ）、ＴＭ３；１０４−１２６（Ｓ）、Ｔ
Ｍ４；２０５−２２７（Ｐ）、ＴＭ５；２４３−２６５
（Ｓ）、ＴＭ６；２６９−２９１（Ｓ）］ odorant receptor S18(AF121975)；163/310 (52%) 配列番号２０６［ＴＭ１；１−２３（Ｓ）、ＴＭ２；２
７−４９（Ｐ）、ＴＭ３；６５−８７（Ｓ）、ＴＭ４；
１０８−１３０（Ｓ）、ＴＭ５；２０５−２２７
（Ｐ）、ＴＭ６；２４２−２６４（Ｓ）、ＴＭ７；２６
８−２９０（Ｓ）］ olfactory receptor 67(AF133300)；158/309 (51%) 配列番号２０８［ＴＭ１；３２−５４（Ｐ）、ＴＭ２；
６６−８８（Ｐ）、ＴＭ３；９８−１２０（Ｓ）、ＴＭ
４；１３７−１５９（Ｓ）、ＴＭ５；２１０−２３１
（Ｐ）、ＴＭ６；２４３−２６５（Ｐ）］ odorant receptor S51(AF121981)；112/159 (70%) 配列番号２１０［ＴＭ１；３０−５２（Ｐ）、ＴＭ２；
１００−１２２（Ｐ）、ＴＭ３；１２７−１４９
（Ｐ）、ＴＭ４；１５３−１７５（Ｐ）、ＴＭ５；２０
９−２３１（Ｐ）、ＴＭ６；２４３−２６５（Ｓ）、Ｔ
Ｍ７；２７４−２９６（Ｓ）］ odorant receptor S46(AF121979)；198/307 (64%)
（Ｐ）、ＴＭ２；６２−８４（Ｓ）、ＴＭ３；９６−１
１８（Ｐ）、ＴＭ４；１４１−１６３（Ｓ）、ＴＭ５；
２０４−２２５（Ｐ）、ＴＭ６；２３９−２６１
（Ｐ）、ＴＭ７；２６８−２９０（Ｓ）］odorant rece
ptor MOR83(AB030894)；159/301 (52%) 配列番号２０４［ＴＭ１；３１−５３（Ｐ）、ＴＭ２；
６５−８７（Ｓ）、ＴＭ３；１０４−１２６（Ｓ）、Ｔ
Ｍ４；２０５−２２７（Ｐ）、ＴＭ５；２４３−２６５
（Ｓ）、ＴＭ６；２６９−２９１（Ｓ）］ odorant receptor S18(AF121975)；163/310 (52%) 配列番号２０６［ＴＭ１；１−２３（Ｓ）、ＴＭ２；２
７−４９（Ｐ）、ＴＭ３；６５−８７（Ｓ）、ＴＭ４；
１０８−１３０（Ｓ）、ＴＭ５；２０５−２２７
（Ｐ）、ＴＭ６；２４２−２６４（Ｓ）、ＴＭ７；２６
８−２９０（Ｓ）］ olfactory receptor 67(AF133300)；158/309 (51%) 配列番号２０８［ＴＭ１；３２−５４（Ｐ）、ＴＭ２；
６６−８８（Ｐ）、ＴＭ３；９８−１２０（Ｓ）、ＴＭ
４；１３７−１５９（Ｓ）、ＴＭ５；２１０−２３１
（Ｐ）、ＴＭ６；２４３−２６５（Ｐ）］ odorant receptor S51(AF121981)；112/159 (70%) 配列番号２１０［ＴＭ１；３０−５２（Ｐ）、ＴＭ２；
１００−１２２（Ｐ）、ＴＭ３；１２７−１４９
（Ｐ）、ＴＭ４；１５３−１７５（Ｐ）、ＴＭ５；２０
９−２３１（Ｐ）、ＴＭ６；２４３−２６５（Ｓ）、Ｔ
Ｍ７；２７４−２９６（Ｓ）］ odorant receptor S46(AF121979)；198/307 (64%)
【００６３】配列番号２１２［ＴＭ１；３４−５６
（Ｐ）、ＴＭ２；１０４−１２６（Ｐ）、ＴＭ３；１４
９−１７１（Ｐ）、ＴＭ４；２１０−２３２（Ｐ）、Ｔ
Ｍ５；２４７−２６９（Ｓ）、ＴＭ６；２７６−２９８
（Ｓ）］ odorant receptor S46(AF121979)；209/307 (68%) 配列番号２１４［ＴＭ１；３−２５（Ｓ）、ＴＭ２；３
１−５３（Ｐ）、ＴＭ３；１０６−１２８（Ｐ）、ＴＭ
４；１３２−１５４（Ｓ）、ＴＭ５；１５６−１７８
（Ｓ）、ＴＭ６；２０３−２２５（Ｐ）、ＴＭ７；２４
２−２６４（Ｐ）、ＴＭ８；２７１−２９３（Ｓ）］ odorant receptor S46(AF121979)；174/306 (56%) 配列番号２１６［ＴＭ１；３６−５８（Ｐ）、ＴＭ２；
１０１−１２３（Ｐ）、ＴＭ３；１４１−１６３
（Ｐ）、ＴＭ４；１８１−２０３（Ｐ）、ＴＭ５；２０
６−２２７（Ｐ）、ＴＭ６；２７０−２９２（Ｓ）］ odorant receptor S46(AF121979)；178/307 (57%) 配列番号２１８［ＴＭ１；２６−４８（Ｐ）、ＴＭ２；
６５−８７（Ｓ）、ＴＭ３；１０４−１２６（Ｓ）、Ｔ
Ｍ４；１４２−１６４（Ｓ）、ＴＭ５；２０４−２２６
（Ｐ）、ＴＭ６；２４０−２６２（Ｐ）、ＴＭ７；２７
６−２９７（Ｓ）］ olfactory receptor-like protein COR3'beta(L1743
2)；159/301 (52%) 配列番号２２０［ＴＭ１；２１−４３（Ｐ）、ＴＭ２；
８４−１０６（Ｓ）、ＴＭ３；１１６−１３８（Ｓ）、
ＴＭ４；１４５−１６７（Ｐ）、ＴＭ５；１８２−２０
４（Ｓ）、ＴＭ６；２１０−２３２（Ｐ）、ＴＭ７；２
４０−２６２（Ｓ）、ＴＭ８；２７２−２９４（Ｓ）］ odorant receptor S46(AF121979)；192/310 (61%)
（Ｐ）、ＴＭ２；１０４−１２６（Ｐ）、ＴＭ３；１４
９−１７１（Ｐ）、ＴＭ４；２１０−２３２（Ｐ）、Ｔ
Ｍ５；２４７−２６９（Ｓ）、ＴＭ６；２７６−２９８
（Ｓ）］ odorant receptor S46(AF121979)；209/307 (68%) 配列番号２１４［ＴＭ１；３−２５（Ｓ）、ＴＭ２；３
１−５３（Ｐ）、ＴＭ３；１０６−１２８（Ｐ）、ＴＭ
４；１３２−１５４（Ｓ）、ＴＭ５；１５６−１７８
（Ｓ）、ＴＭ６；２０３−２２５（Ｐ）、ＴＭ７；２４
２−２６４（Ｐ）、ＴＭ８；２７１−２９３（Ｓ）］ odorant receptor S46(AF121979)；174/306 (56%) 配列番号２１６［ＴＭ１；３６−５８（Ｐ）、ＴＭ２；
１０１−１２３（Ｐ）、ＴＭ３；１４１−１６３
（Ｐ）、ＴＭ４；１８１−２０３（Ｐ）、ＴＭ５；２０
６−２２７（Ｐ）、ＴＭ６；２７０−２９２（Ｓ）］ odorant receptor S46(AF121979)；178/307 (57%) 配列番号２１８［ＴＭ１；２６−４８（Ｐ）、ＴＭ２；
６５−８７（Ｓ）、ＴＭ３；１０４−１２６（Ｓ）、Ｔ
Ｍ４；１４２−１６４（Ｓ）、ＴＭ５；２０４−２２６
（Ｐ）、ＴＭ６；２４０−２６２（Ｐ）、ＴＭ７；２７
６−２９７（Ｓ）］ olfactory receptor-like protein COR3'beta(L1743
2)；159/301 (52%) 配列番号２２０［ＴＭ１；２１−４３（Ｐ）、ＴＭ２；
８４−１０６（Ｓ）、ＴＭ３；１１６−１３８（Ｓ）、
ＴＭ４；１４５−１６７（Ｐ）、ＴＭ５；１８２−２０
４（Ｓ）、ＴＭ６；２１０−２３２（Ｐ）、ＴＭ７；２
４０−２６２（Ｓ）、ＴＭ８；２７２−２９４（Ｓ）］ odorant receptor S46(AF121979)；192/310 (61%)
【００６４】配列番号２２２［ＴＭ１；２７−４９
（Ｓ）、ＴＭ２；７５−９７（Ｓ）、ＴＭ３；１１３−
１３５（Ｐ）、ＴＭ４；１４０−１６２（Ｐ）、ＴＭ
５；１６９−１９０（Ｓ）、ＴＭ６；２０３−２２５
（Ｓ）］ olfactory receptor(AJ133430)；190/247 (76%) 配列番号２２４［ＴＭ１；１−２０（Ｓ）、ＴＭ２；２
８−５０（Ｐ）、ＴＭ３；６１−８３（Ｓ）、ＴＭ４；
９２−１１４（Ｓ）、ＴＭ５；１３３−１５５（Ｐ）、
ＴＭ６；１９５−２１７（Ｐ）］ HUMAN OLFACTORY RECEPTOR 5I1(Q13606)；95/214 (44%) 配列番号２２６［ＴＭ１；２７−４９（Ｐ）、ＴＭ２；
５８−８０（Ｓ）、ＴＭ３；９３−１１５（Ｓ）、ＴＭ
４；１４３−１６５（Ｓ）、ＴＭ５；１７８−２００
（Ｓ）、ＴＭ６；２０６−２２７（Ｐ）、ＴＭ７；２４
１−２６３（Ｐ）、ＴＭ８；２６８−２９０（Ｓ）］ odorant receptor MOR83(AB030894)；171/307 (55%) 配列番号２２８［ＴＭ１；２５−４７（Ｐ）、ＴＭ２；
５５−７７（Ｓ）、ＴＭ３；１００−１２２（Ｓ）、Ｔ
Ｍ４；１４３−１６５（Ｐ）、ＴＭ５；１７０−１９２
（Ｓ）、ＴＭ６；２０５−２２６（Ｐ）、ＴＭ７；２４
１−２６３（Ｐ）］ odorant receptor MOR83(AB030894)；158/308 (51%) 配列番号２３０［ＴＭ１；１−２３（Ｐ）、ＴＭ２；２
７−４９（Ｓ）、ＴＭ３；８１−１０３（Ｐ）、ＴＭ
４；１４３−１６５（Ｐ）、ＴＭ５；１８４−２０６
（Ｐ）、ＴＭ６；２１４−２３６（Ｐ）］ olfactory receptor [Homo sapiens] (AJ003147)；154/
249 (61%)
（Ｓ）、ＴＭ２；７５−９７（Ｓ）、ＴＭ３；１１３−
１３５（Ｐ）、ＴＭ４；１４０−１６２（Ｐ）、ＴＭ
５；１６９−１９０（Ｓ）、ＴＭ６；２０３−２２５
（Ｓ）］ olfactory receptor(AJ133430)；190/247 (76%) 配列番号２２４［ＴＭ１；１−２０（Ｓ）、ＴＭ２；２
８−５０（Ｐ）、ＴＭ３；６１−８３（Ｓ）、ＴＭ４；
９２−１１４（Ｓ）、ＴＭ５；１３３−１５５（Ｐ）、
ＴＭ６；１９５−２１７（Ｐ）］ HUMAN OLFACTORY RECEPTOR 5I1(Q13606)；95/214 (44%) 配列番号２２６［ＴＭ１；２７−４９（Ｐ）、ＴＭ２；
５８−８０（Ｓ）、ＴＭ３；９３−１１５（Ｓ）、ＴＭ
４；１４３−１６５（Ｓ）、ＴＭ５；１７８−２００
（Ｓ）、ＴＭ６；２０６−２２７（Ｐ）、ＴＭ７；２４
１−２６３（Ｐ）、ＴＭ８；２６８−２９０（Ｓ）］ odorant receptor MOR83(AB030894)；171/307 (55%) 配列番号２２８［ＴＭ１；２５−４７（Ｐ）、ＴＭ２；
５５−７７（Ｓ）、ＴＭ３；１００−１２２（Ｓ）、Ｔ
Ｍ４；１４３−１６５（Ｐ）、ＴＭ５；１７０−１９２
（Ｓ）、ＴＭ６；２０５−２２６（Ｐ）、ＴＭ７；２４
１−２６３（Ｐ）］ odorant receptor MOR83(AB030894)；158/308 (51%) 配列番号２３０［ＴＭ１；１−２３（Ｐ）、ＴＭ２；２
７−４９（Ｓ）、ＴＭ３；８１−１０３（Ｐ）、ＴＭ
４；１４３−１６５（Ｐ）、ＴＭ５；１８４−２０６
（Ｐ）、ＴＭ６；２１４−２３６（Ｐ）］ olfactory receptor [Homo sapiens] (AJ003147)；154/
249 (61%)
【００６５】配列番号２３２［ＴＭ１；２７−４９
（Ｐ）、ＴＭ２；６３−８５（Ｐ）、ＴＭ３；１０３−
１２５（Ｓ）、ＴＭ４；１４３−１６５（Ｓ）、ＴＭ
５；２０４−２２６（Ｐ）、ＴＭ６；２３８−２５９
（Ｓ）、ＴＭ７；２７３−２９５（Ｓ）］ olfactory receptor P2 [Mus musculus] (AF247657)；1
94/302 (64%) 配列番号２３４［ＴＭ１；３４−５５（Ｓ）、ＴＭ２；
１０４−１２６（Ｐ）、ＴＭ３；１４８−１７０
（Ｓ）、ＴＭ４；２０４−２２６（Ｐ）、ＴＭ５；２４
２−２６４（Ｓ）、ＴＭ６；２７３−２９４（Ｓ）］ HsOLF1 [Homo sapiens] (U56420)；153/304 (50%) 配列番号２３６［ＴＭ１；２２−４４（Ｓ）、ＴＭ２；
６２−８４（Ｓ）、ＴＭ３；９７−１１９（Ｐ）、ＴＭ
４；１４３−１６５（Ｐ）、ＴＭ５；２０７−２２９
（Ｐ）、ＴＭ６；２４２−２６３（Ｓ）、ＴＭ７；２７
８−３００（Ｓ）］ olfactory receptor C6 [Mus musculus] (AF102523)；1
49/305 (48%) 配列番号２３８［ＴＭ１；３４−５６（Ｐ）、ＴＭ２；
９５−１１７（Ｓ）、ＴＭ３；１４０−１６２（Ｐ）、
ＴＭ４；１６６−１８８（Ｓ）、ＴＭ５；２０２−２２
４（Ｐ）、ＴＭ６；２３８−２６０（Ｓ）］ odorant receptor [Mus musculus] (X92969)；201/276
(72%) 配列番号２４０［ＴＭ１；２６−４８（Ｐ）、ＴＭ２；
６９−９１（Ｐ）、ＴＭ３；９５−１１７（Ｓ）、ＴＭ
４；１３６−１５８（Ｐ）、ＴＭ５；１６６−１８８
（Ｓ）、ＴＭ６；２０５−２２７（Ｐ）、ＴＭ７；２３
７−２５９（Ｓ）、ＴＭ８；２７１−２９２（Ｓ）］ odorant receptor [Mus musculus] (X92969)；270/309
(87%)
（Ｐ）、ＴＭ２；６３−８５（Ｐ）、ＴＭ３；１０３−
１２５（Ｓ）、ＴＭ４；１４３−１６５（Ｓ）、ＴＭ
５；２０４−２２６（Ｐ）、ＴＭ６；２３８−２５９
（Ｓ）、ＴＭ７；２７３−２９５（Ｓ）］ olfactory receptor P2 [Mus musculus] (AF247657)；1
94/302 (64%) 配列番号２３４［ＴＭ１；３４−５５（Ｓ）、ＴＭ２；
１０４−１２６（Ｐ）、ＴＭ３；１４８−１７０
（Ｓ）、ＴＭ４；２０４−２２６（Ｐ）、ＴＭ５；２４
２−２６４（Ｓ）、ＴＭ６；２７３−２９４（Ｓ）］ HsOLF1 [Homo sapiens] (U56420)；153/304 (50%) 配列番号２３６［ＴＭ１；２２−４４（Ｓ）、ＴＭ２；
６２−８４（Ｓ）、ＴＭ３；９７−１１９（Ｐ）、ＴＭ
４；１４３−１６５（Ｐ）、ＴＭ５；２０７−２２９
（Ｐ）、ＴＭ６；２４２−２６３（Ｓ）、ＴＭ７；２７
８−３００（Ｓ）］ olfactory receptor C6 [Mus musculus] (AF102523)；1
49/305 (48%) 配列番号２３８［ＴＭ１；３４−５６（Ｐ）、ＴＭ２；
９５−１１７（Ｓ）、ＴＭ３；１４０−１６２（Ｐ）、
ＴＭ４；１６６−１８８（Ｓ）、ＴＭ５；２０２−２２
４（Ｐ）、ＴＭ６；２３８−２６０（Ｓ）］ odorant receptor [Mus musculus] (X92969)；201/276
(72%) 配列番号２４０［ＴＭ１；２６−４８（Ｐ）、ＴＭ２；
６９−９１（Ｐ）、ＴＭ３；９５−１１７（Ｓ）、ＴＭ
４；１３６−１５８（Ｐ）、ＴＭ５；１６６−１８８
（Ｓ）、ＴＭ６；２０５−２２７（Ｐ）、ＴＭ７；２３
７−２５９（Ｓ）、ＴＭ８；２７１−２９２（Ｓ）］ odorant receptor [Mus musculus] (X92969)；270/309
(87%)
【００６６】配列番号２４２［ＴＭ１；２６−４８
（Ｐ）、ＴＭ２；６０−８２（Ｓ）、ＴＭ３；９３−１
１５（Ｐ）、ＴＭ４；１４４−１６６（Ｓ）、ＴＭ５；
１７６−１９８（Ｓ）、ＴＭ６；２０２−２２３
（Ｐ）、ＴＭ７；２３４−２５５（Ｓ）、ＴＭ８；２６
９−２９１（Ｓ）］ odorant receptor MOR18 [Mus musculus] (AB030895)；
183/303 (60%) 配列番号２４４［ＴＭ１；８−３０（Ｓ）、ＴＭ２；４
３−６５（Ｓ）、ＴＭ３；８７−１０９（Ｐ）、ＴＭ
４；１３１−１５３（Ｓ）、ＴＭ５；１７３−１９５
（Ｓ）、ＴＭ６；２３３−２５５（Ｐ）、ＴＭ７；２７
１−２９２（Ｐ）、ＴＭ８；３０２−３２３（Ｐ）］ odorant receptor MOR18 [Mus musculus] (AB030895)；
195/301 (64%) 配列番号２４６［ＴＭ１；４５−６７（Ｐ）、ＴＭ２；
１１２−１３４（Ｓ）、ＴＭ３；１４３−１６５
（Ｓ）、ＴＭ４；１６７−１８９（Ｓ）、ＴＭ５；１９
２−２１４（Ｓ）、ＴＭ６；２１９−２４０（Ｐ）、Ｔ
Ｍ７；２５１−２７３（Ｐ）、ＴＭ８；２８１−３０３
（Ｐ）］ odorant receptor A16 [Mus musculus] (AB030896)；16
1/300 (53%) 配列番号２４８［ＴＭ１；１１８−１４０（Ｐ）、ＴＭ
２；１５９−１８１（Ｐ）、ＴＭ３；１８６−２０８
（Ｓ）、ＴＭ４；２２２−２４４（Ｐ）、ＴＭ５；２６
３−２８５（Ｐ）、ＴＭ６；２９４−３１６（Ｓ）］ odorant receptor MOR18 [Mus musculus] (AB030895)；
114/193 (59%) 配列番号２５０［ＴＭ１；２−２４（Ｓ）、ＴＭ２；２
８−４９（Ｓ）、ＴＭ３；５６−７８（Ｓ）、ＴＭ４；
９１−１１３（Ｐ）、ＴＭ５；１２３−１４５（Ｓ）、
ＴＭ６；１６１−１８３（Ｓ）、ＴＭ７；２０１−２２
２（Ｐ）］ olfactory receptor OR18 - rat(S29710)；175/263 (66
%)
（Ｐ）、ＴＭ２；６０−８２（Ｓ）、ＴＭ３；９３−１
１５（Ｐ）、ＴＭ４；１４４−１６６（Ｓ）、ＴＭ５；
１７６−１９８（Ｓ）、ＴＭ６；２０２−２２３
（Ｐ）、ＴＭ７；２３４−２５５（Ｓ）、ＴＭ８；２６
９−２９１（Ｓ）］ odorant receptor MOR18 [Mus musculus] (AB030895)；
183/303 (60%) 配列番号２４４［ＴＭ１；８−３０（Ｓ）、ＴＭ２；４
３−６５（Ｓ）、ＴＭ３；８７−１０９（Ｐ）、ＴＭ
４；１３１−１５３（Ｓ）、ＴＭ５；１７３−１９５
（Ｓ）、ＴＭ６；２３３−２５５（Ｐ）、ＴＭ７；２７
１−２９２（Ｐ）、ＴＭ８；３０２−３２３（Ｐ）］ odorant receptor MOR18 [Mus musculus] (AB030895)；
195/301 (64%) 配列番号２４６［ＴＭ１；４５−６７（Ｐ）、ＴＭ２；
１１２−１３４（Ｓ）、ＴＭ３；１４３−１６５
（Ｓ）、ＴＭ４；１６７−１８９（Ｓ）、ＴＭ５；１９
２−２１４（Ｓ）、ＴＭ６；２１９−２４０（Ｐ）、Ｔ
Ｍ７；２５１−２７３（Ｐ）、ＴＭ８；２８１−３０３
（Ｐ）］ odorant receptor A16 [Mus musculus] (AB030896)；16
1/300 (53%) 配列番号２４８［ＴＭ１；１１８−１４０（Ｐ）、ＴＭ
２；１５９−１８１（Ｐ）、ＴＭ３；１８６−２０８
（Ｓ）、ＴＭ４；２２２−２４４（Ｐ）、ＴＭ５；２６
３−２８５（Ｐ）、ＴＭ６；２９４−３１６（Ｓ）］ odorant receptor MOR18 [Mus musculus] (AB030895)；
114/193 (59%) 配列番号２５０［ＴＭ１；２−２４（Ｓ）、ＴＭ２；２
８−４９（Ｓ）、ＴＭ３；５６−７８（Ｓ）、ＴＭ４；
９１−１１３（Ｐ）、ＴＭ５；１２３−１４５（Ｓ）、
ＴＭ６；１６１−１８３（Ｓ）、ＴＭ７；２０１−２２
２（Ｐ）］ olfactory receptor OR18 - rat(S29710)；175/263 (66
%)
【００６７】配列番号２５２［ＴＭ１；５−２７
（Ｓ）、ＴＭ２；５１−７３（Ｐ）、ＴＭ３；１２３−
１４５（Ｐ）、ＴＭ４；１６７−１８９（Ｐ）、ＴＭ
５；２１６−２３８（Ｐ）、ＴＭ６；２６１−２８３
（Ｐ）、ＴＭ７；２９５−３１７（Ｓ）］odorant rece
ptor MOR18 [Mus musculus] (AB030895)；257/301 (85
%) 配列番号２５４［ＴＭ１；２８−４９（Ｓ）、ＴＭ２；
１４３−１６５（Ｓ）、ＴＭ３；１７６−１９８
（Ｓ）、ＴＭ４；２０２−２２３（Ｐ）、ＴＭ５；２３
５−２５７（Ｐ）、ＴＭ６；２６４−２８６（Ｓ）］ odorant receptor MOR18 [Mus musculus] (AB030895)；
169/307 (55%) 配列番号２５６［ＴＭ１；１３−３５（Ｓ）、ＴＭ２；
１５６−１７８（Ｐ）、ＴＭ３；１９２−２１４
（Ｐ）、ＴＭ４；２５２−２７４（Ｐ）、ＴＭ５；２８
７−３０９（Ｐ）、ＴＭ６；３１３−３３５（Ｓ）］ olfactory receptor OR18 - rat(S29710)；181/300 (60
%) 配列番号２５８［ＴＭ１；２５−４７（Ｐ）、ＴＭ２；
５８−８０（Ｐ）、ＴＭ３；９３−１１５（Ｓ）、ＴＭ
４；１４０−１６２（Ｐ）、ＴＭ５；１８９−２１１
（Ｐ）、ＴＭ６；２３７−２５９（Ｐ）］ olfactory receptor OR18 - rat(S29710)；183/302 (60
%) 配列番号２６０［ＴＭ１；９−３１（Ｐ）、ＴＭ２；６
７−８８（Ｓ）、ＴＭ３；９０−１１２（Ｐ）、ＴＭ
４；１１６−１３８（Ｓ）、ＴＭ５；１４４−１６６
（Ｐ）、ＴＭ６；１７９−２０１（Ｓ）、ＴＭ７；２１
０−２３１（Ｐ）、ＴＭ８；２７０−２９２（Ｓ）］ HsOLF1 [Homo sapiens] (U56420)；166/307 (54%)
（Ｓ）、ＴＭ２；５１−７３（Ｐ）、ＴＭ３；１２３−
１４５（Ｐ）、ＴＭ４；１６７−１８９（Ｐ）、ＴＭ
５；２１６−２３８（Ｐ）、ＴＭ６；２６１−２８３
（Ｐ）、ＴＭ７；２９５−３１７（Ｓ）］odorant rece
ptor MOR18 [Mus musculus] (AB030895)；257/301 (85
%) 配列番号２５４［ＴＭ１；２８−４９（Ｓ）、ＴＭ２；
１４３−１６５（Ｓ）、ＴＭ３；１７６−１９８
（Ｓ）、ＴＭ４；２０２−２２３（Ｐ）、ＴＭ５；２３
５−２５７（Ｐ）、ＴＭ６；２６４−２８６（Ｓ）］ odorant receptor MOR18 [Mus musculus] (AB030895)；
169/307 (55%) 配列番号２５６［ＴＭ１；１３−３５（Ｓ）、ＴＭ２；
１５６−１７８（Ｐ）、ＴＭ３；１９２−２１４
（Ｐ）、ＴＭ４；２５２−２７４（Ｐ）、ＴＭ５；２８
７−３０９（Ｐ）、ＴＭ６；３１３−３３５（Ｓ）］ olfactory receptor OR18 - rat(S29710)；181/300 (60
%) 配列番号２５８［ＴＭ１；２５−４７（Ｐ）、ＴＭ２；
５８−８０（Ｐ）、ＴＭ３；９３−１１５（Ｓ）、ＴＭ
４；１４０−１６２（Ｐ）、ＴＭ５；１８９−２１１
（Ｐ）、ＴＭ６；２３７−２５９（Ｐ）］ olfactory receptor OR18 - rat(S29710)；183/302 (60
%) 配列番号２６０［ＴＭ１；９−３１（Ｐ）、ＴＭ２；６
７−８８（Ｓ）、ＴＭ３；９０−１１２（Ｐ）、ＴＭ
４；１１６−１３８（Ｓ）、ＴＭ５；１４４−１６６
（Ｐ）、ＴＭ６；１７９−２０１（Ｓ）、ＴＭ７；２１
０−２３１（Ｐ）、ＴＭ８；２７０−２９２（Ｓ）］ HsOLF1 [Homo sapiens] (U56420)；166/307 (54%)
【００６８】配列番号２６２［ＴＭ１；２０−４２
（Ｐ）、ＴＭ２；６０−８２（Ｓ）、ＴＭ３；１００−
１２２（Ｓ）、ＴＭ４；１４６−１６８（Ｐ）、ＴＭ
５；２０２−２２４（Ｐ）、ＴＭ６；２４２−２６４
（Ｓ）、ＴＭ７；２７０−２９２（Ｐ）］ olfactory receptor [Homo sapiens] (AF065860)；159/
214 (74%) 配列番号２６４［ＴＭ１；１７−３９（Ｓ）、ＴＭ２；
９１−１１３（Ｓ）、ＴＭ３；１１７−１３９（Ｐ）、
ＴＭ４；１４４−１６６（Ｐ）、ＴＭ５；１８３−２０
５（Ｓ）、ＴＭ６；２０８−２２９（Ｐ）、ＴＭ７；２
４４−２６５（Ｓ）、ＴＭ８；２７４−２９５（Ｓ）］ HsOLF1 [Homo sapiens] (U56420)；161/306 (52%) 配列番号２６６［ＴＭ１；３１−５３（Ｐ）、ＴＭ２；
６３−８５（Ｓ）、ＴＭ３；１０２−１２４（Ｐ）、Ｔ
Ｍ４；１４２−１６４（Ｐ）、ＴＭ５；２０３−２２５
（Ｐ）、ＴＭ６；２４１−２６２（Ｓ）、ＴＭ７；２７
１−２９３（Ｓ）］ HsOLF1 [Homo sapiens] (U56420)；180/313 (57%) 配列番号２６８［ＴＭ１；４４−６６（Ｐ）、ＴＭ２；
７０−９２（Ｓ）、ＴＭ３；９４−１１６（Ｐ）、ＴＭ
４；１５２−１７４（Ｐ）、ＴＭ５；１８２−２０４
（Ｓ）、ＴＭ６；２１０−２３２（Ｐ）］ olfactory receptor [Homo sapiens] (AF065860)；142/
216 (65%) 配列番号２７０［ＴＭ１；４５−６７（Ｐ）、ＴＭ２；
７８−１００（Ｓ）、ＴＭ３；１１６−１３８（Ｐ）、
ＴＭ４；１５８−１８０（Ｐ）、ＴＭ５；１９３−２１
５（Ｐ）、ＴＭ６；２２４−２４５（Ｐ）、ＴＭ７；２
５８−２８０（Ｓ）、ＴＭ８；２９０−３１１（Ｓ）］ olfactory receptor H7 [Mus musculus] (AF102540)；1
47/222 (66%)
（Ｐ）、ＴＭ２；６０−８２（Ｓ）、ＴＭ３；１００−
１２２（Ｓ）、ＴＭ４；１４６−１６８（Ｐ）、ＴＭ
５；２０２−２２４（Ｐ）、ＴＭ６；２４２−２６４
（Ｓ）、ＴＭ７；２７０−２９２（Ｐ）］ olfactory receptor [Homo sapiens] (AF065860)；159/
214 (74%) 配列番号２６４［ＴＭ１；１７−３９（Ｓ）、ＴＭ２；
９１−１１３（Ｓ）、ＴＭ３；１１７−１３９（Ｐ）、
ＴＭ４；１４４−１６６（Ｐ）、ＴＭ５；１８３−２０
５（Ｓ）、ＴＭ６；２０８−２２９（Ｐ）、ＴＭ７；２
４４−２６５（Ｓ）、ＴＭ８；２７４−２９５（Ｓ）］ HsOLF1 [Homo sapiens] (U56420)；161/306 (52%) 配列番号２６６［ＴＭ１；３１−５３（Ｐ）、ＴＭ２；
６３−８５（Ｓ）、ＴＭ３；１０２−１２４（Ｐ）、Ｔ
Ｍ４；１４２−１６４（Ｐ）、ＴＭ５；２０３−２２５
（Ｐ）、ＴＭ６；２４１−２６２（Ｓ）、ＴＭ７；２７
１−２９３（Ｓ）］ HsOLF1 [Homo sapiens] (U56420)；180/313 (57%) 配列番号２６８［ＴＭ１；４４−６６（Ｐ）、ＴＭ２；
７０−９２（Ｓ）、ＴＭ３；９４−１１６（Ｐ）、ＴＭ
４；１５２−１７４（Ｐ）、ＴＭ５；１８２−２０４
（Ｓ）、ＴＭ６；２１０−２３２（Ｐ）］ olfactory receptor [Homo sapiens] (AF065860)；142/
216 (65%) 配列番号２７０［ＴＭ１；４５−６７（Ｐ）、ＴＭ２；
７８−１００（Ｓ）、ＴＭ３；１１６−１３８（Ｐ）、
ＴＭ４；１５８−１８０（Ｐ）、ＴＭ５；１９３−２１
５（Ｐ）、ＴＭ６；２２４−２４５（Ｐ）、ＴＭ７；２
５８−２８０（Ｓ）、ＴＭ８；２９０−３１１（Ｓ）］ olfactory receptor H7 [Mus musculus] (AF102540)；1
47/222 (66%)
【００６９】配列番号２７２［ＴＭ１；２９−５１
（Ｐ）、ＴＭ２；６４−８６（Ｐ）、ＴＭ３；９８−１
２０（Ｐ）、ＴＭ４；１４３−１６５（Ｐ）、ＴＭ５；
２０１−２２３（Ｐ）、ＴＭ６；２３８−２５９
（Ｓ）、ＴＭ７；２６９−２９１（Ｓ）］ olfactory receptor C6 [Mus musculus] (AF102523)；1
40/302 (46%) 配列番号２７４［ＴＭ１；２６−４８（Ｐ）、ＴＭ２；
６１−８３（Ｐ）、ＴＭ３；９８−１２０（Ｐ）、ＴＭ
４；１３５−１５７（Ｐ）、ＴＭ５；１９６−２１８
（Ｐ）、ＴＭ６；２３９−２６０（Ｓ）］ olfactory protein [Rattus norvegicus] (M64378)；11
5/258 (44%) 配列番号２７６［ＴＭ１；４８−７０（Ｐ）、ＴＭ２；
９１−１１３（Ｓ）、ＴＭ３；１３０−１５２（Ｓ）、
ＴＭ４；１７６−１９８（Ｓ）、ＴＭ５；２３７−２５
９（Ｐ）、ＴＭ６；２９９−３２１（Ｓ）］ HsOLF1 [Homo sapiens] (U56420)；167/303 (55%) 配列番号２７８［ＴＭ１；３２−５４（Ｐ）、ＴＭ２；
９６−１１８（Ｐ）、ＴＭ３；１４５−１６７（Ｐ）、
ＴＭ４；２０１−２２３（Ｐ）、ＴＭ５；２３９−２６
１（Ｐ）、ＴＭ６；２６９−２９１（Ｓ）］ olfactory receptor OR93Gib [Hylobates lar] (AF0455
80)；166/304 (54%) 配列番号２８０［ＴＭ１；７−２９（Ｐ）、ＴＭ２；３
５−５７（Ｓ）、ＴＭ３；７０−９２（Ｐ）、ＴＭ４；
１１５−１３７（Ｓ）、ＴＭ５；１７７−１９９
（Ｐ）、ＴＭ６；２４７−２６８（Ｐ）］ olfactory receptor 4 [Gallus gallus] (X94744)；156
/282 (55%)
（Ｐ）、ＴＭ２；６４−８６（Ｐ）、ＴＭ３；９８−１
２０（Ｐ）、ＴＭ４；１４３−１６５（Ｐ）、ＴＭ５；
２０１−２２３（Ｐ）、ＴＭ６；２３８−２５９
（Ｓ）、ＴＭ７；２６９−２９１（Ｓ）］ olfactory receptor C6 [Mus musculus] (AF102523)；1
40/302 (46%) 配列番号２７４［ＴＭ１；２６−４８（Ｐ）、ＴＭ２；
６１−８３（Ｐ）、ＴＭ３；９８−１２０（Ｐ）、ＴＭ
４；１３５−１５７（Ｐ）、ＴＭ５；１９６−２１８
（Ｐ）、ＴＭ６；２３９−２６０（Ｓ）］ olfactory protein [Rattus norvegicus] (M64378)；11
5/258 (44%) 配列番号２７６［ＴＭ１；４８−７０（Ｐ）、ＴＭ２；
９１−１１３（Ｓ）、ＴＭ３；１３０−１５２（Ｓ）、
ＴＭ４；１７６−１９８（Ｓ）、ＴＭ５；２３７−２５
９（Ｐ）、ＴＭ６；２９９−３２１（Ｓ）］ HsOLF1 [Homo sapiens] (U56420)；167/303 (55%) 配列番号２７８［ＴＭ１；３２−５４（Ｐ）、ＴＭ２；
９６−１１８（Ｐ）、ＴＭ３；１４５−１６７（Ｐ）、
ＴＭ４；２０１−２２３（Ｐ）、ＴＭ５；２３９−２６
１（Ｐ）、ＴＭ６；２６９−２９１（Ｓ）］ olfactory receptor OR93Gib [Hylobates lar] (AF0455
80)；166/304 (54%) 配列番号２８０［ＴＭ１；７−２９（Ｐ）、ＴＭ２；３
５−５７（Ｓ）、ＴＭ３；７０−９２（Ｐ）、ＴＭ４；
１１５−１３７（Ｓ）、ＴＭ５；１７７−１９９
（Ｐ）、ＴＭ６；２４７−２６８（Ｐ）］ olfactory receptor 4 [Gallus gallus] (X94744)；156
/282 (55%)
【００７０】配列番号２８２［ＴＭ１；３８−６０
（Ｐ）、ＴＭ２；１０３−１２５（Ｐ）、ＴＭ３；１３
２−１５４（Ｐ）、ＴＭ４；１６７−１８９（Ｐ）、Ｔ
Ｍ５；２０７−２２９（Ｐ）、ＴＭ６；２４６−２６７
（Ｐ）、ＴＭ７；２７８−２９９（Ｐ）］ olfactory receptor OR93Gib [Hylobates lar] (AF0455
80)；161/302 (53%) 配列番号２８４［ＴＭ１；２８−５０（Ｐ）、ＴＭ２；
９８−１２０（Ｐ）、ＴＭ３；１４０−１６２（Ｐ）、
ＴＭ４；２１０−２３２（Ｐ）、ＴＭ５；２４０−２６
２（Ｓ）、ＴＭ６；２７２−２９４（Ｓ）］ olfactory receptor OR93Ch [Pan troglodytes] (AF045
577)；165/308 (53%) 配列番号２８６［ＴＭ１；１−２３（Ｓ）、ＴＭ２；２
５−４７（Ｐ）、ＴＭ３；５６−７８（Ｓ）、ＴＭ４；
９０−１１２（Ｓ）、ＴＭ５；１４２−１６４（Ｓ）、
ＴＭ６；１９８−２２０（Ｐ）、ＴＭ７；２３６−２５
８（Ｐ）、ＴＭ８；２６９−２９０（Ｓ）］ olfactory receptor P2 [Mus musculus] (AF247657)；1
34/302 (44%) 配列番号２８８［ＴＭ１；９３−１１５（Ｓ）、ＴＭ
２；１２８−１５０（Ｓ）、ＴＭ３；１６１−１８３
（Ｐ）、ＴＭ４；２１２−２３４（Ｐ）、ＴＭ５；２６
４−２８６（Ｐ）、ＴＭ６；３０５−３２７（Ｓ）］ olfactory receptor [Homo sapiens] (AJ003147)；183/
305 (60%) 配列番号２９０［ＴＭ１；５−２７（Ｓ）、ＴＭ２；４
０−６２（Ｓ）、ＴＭ３；８３−１０５（Ｐ）、ＴＭ
４；１３５−１５７（Ｐ）、ＴＭ５；１８１−２０３
（Ｓ）、ＴＭ６；２１３−２３５（Ｓ）］ olfactory receptor [Homo sapiens] (Z98744)；160/25
0 (64%)
（Ｐ）、ＴＭ２；１０３−１２５（Ｐ）、ＴＭ３；１３
２−１５４（Ｐ）、ＴＭ４；１６７−１８９（Ｐ）、Ｔ
Ｍ５；２０７−２２９（Ｐ）、ＴＭ６；２４６−２６７
（Ｐ）、ＴＭ７；２７８−２９９（Ｐ）］ olfactory receptor OR93Gib [Hylobates lar] (AF0455
80)；161/302 (53%) 配列番号２８４［ＴＭ１；２８−５０（Ｐ）、ＴＭ２；
９８−１２０（Ｐ）、ＴＭ３；１４０−１６２（Ｐ）、
ＴＭ４；２１０−２３２（Ｐ）、ＴＭ５；２４０−２６
２（Ｓ）、ＴＭ６；２７２−２９４（Ｓ）］ olfactory receptor OR93Ch [Pan troglodytes] (AF045
577)；165/308 (53%) 配列番号２８６［ＴＭ１；１−２３（Ｓ）、ＴＭ２；２
５−４７（Ｐ）、ＴＭ３；５６−７８（Ｓ）、ＴＭ４；
９０−１１２（Ｓ）、ＴＭ５；１４２−１６４（Ｓ）、
ＴＭ６；１９８−２２０（Ｐ）、ＴＭ７；２３６−２５
８（Ｐ）、ＴＭ８；２６９−２９０（Ｓ）］ olfactory receptor P2 [Mus musculus] (AF247657)；1
34/302 (44%) 配列番号２８８［ＴＭ１；９３−１１５（Ｓ）、ＴＭ
２；１２８−１５０（Ｓ）、ＴＭ３；１６１−１８３
（Ｐ）、ＴＭ４；２１２−２３４（Ｐ）、ＴＭ５；２６
４−２８６（Ｐ）、ＴＭ６；３０５−３２７（Ｓ）］ olfactory receptor [Homo sapiens] (AJ003147)；183/
305 (60%) 配列番号２９０［ＴＭ１；５−２７（Ｓ）、ＴＭ２；４
０−６２（Ｓ）、ＴＭ３；８３−１０５（Ｐ）、ＴＭ
４；１３５−１５７（Ｐ）、ＴＭ５；１８１−２０３
（Ｓ）、ＴＭ６；２１３−２３５（Ｓ）］ olfactory receptor [Homo sapiens] (Z98744)；160/25
0 (64%)
【００７１】配列番号２９２［ＴＭ１；３０−５２
（Ｐ）、ＴＭ２；９９−１２１（Ｐ）、ＴＭ３；１４７
−１６９（Ｐ）、ＴＭ４；２０７−２２９（Ｐ）、ＴＭ
５；２４３−２６５（Ｓ）、ＴＭ６；２７４−２９６
（Ｓ）］ chick olfactory receptor 7 [Gallus gallus] (Z7958
6)；151/306 (49%) 配列番号２９４［ＴＭ１；２８−５０（Ｐ）、ＴＭ２；
６６−８８（Ｓ）、ＴＭ３；１０４−１２６（Ｓ）、Ｔ
Ｍ４；１３８−１６０（Ｐ）、ＴＭ５；２０１−２２３
（Ｐ）、ＴＭ６；２４２−２６４（Ｐ）、ＴＭ７；２７
０−２９２（Ｓ）］ olfactory receptor 4 [Gallus gallus] (X94744)；161
/310 (51%) 配列番号２９６［ＴＭ１；２０−４２（Ｐ）、ＴＭ２；
６１−８３（Ｐ）、ＴＭ３；９５−１１７（Ｓ）、ＴＭ
４；１４３−１６５（Ｓ）、ＴＭ５；１７７−１９９
（Ｓ）、ＴＭ６；２０６−２２７（Ｐ）］ olfactory receptor 2 [Gallus gallus] (X94742)；106
/233 (45%) 配列番号２９８［ＴＭ１；２６−４８（Ｐ）、ＴＭ２；
６２−８４（Ｓ）、ＴＭ３；１０４−１２６（Ｐ）、Ｔ
Ｍ４；１４２−１６４（Ｐ）、ＴＭ５；２０７−２２８
（Ｐ）、ＴＭ６；２７１−２９３（Ｓ）、ＴＭ７；３０
６−３２８（Ｐ）］ odorant receptor [Mus musculus] (X92969)；145/302
(48%) 配列番号３００［ＴＭ１；７−２９（Ｓ）、ＴＭ２；５
３−７５（Ｐ）、ＴＭ３；１０１−１２３（Ｓ）、ＴＭ
４；１３２−１５４（Ｓ）、ＴＭ５；１６３−１８５
（Ｐ）、ＴＭ６；１９８−２２０（Ｓ）］ dJ88J8.1 (novel 7 transmembrane receptor (rhodopsi
n family) (olfactory receptor like) protein) (hs6M
1-15)) [Homo sapiens] (AL035402)；173/261 (66%)
（Ｐ）、ＴＭ２；９９−１２１（Ｐ）、ＴＭ３；１４７
−１６９（Ｐ）、ＴＭ４；２０７−２２９（Ｐ）、ＴＭ
５；２４３−２６５（Ｓ）、ＴＭ６；２７４−２９６
（Ｓ）］ chick olfactory receptor 7 [Gallus gallus] (Z7958
6)；151/306 (49%) 配列番号２９４［ＴＭ１；２８−５０（Ｐ）、ＴＭ２；
６６−８８（Ｓ）、ＴＭ３；１０４−１２６（Ｓ）、Ｔ
Ｍ４；１３８−１６０（Ｐ）、ＴＭ５；２０１−２２３
（Ｐ）、ＴＭ６；２４２−２６４（Ｐ）、ＴＭ７；２７
０−２９２（Ｓ）］ olfactory receptor 4 [Gallus gallus] (X94744)；161
/310 (51%) 配列番号２９６［ＴＭ１；２０−４２（Ｐ）、ＴＭ２；
６１−８３（Ｐ）、ＴＭ３；９５−１１７（Ｓ）、ＴＭ
４；１４３−１６５（Ｓ）、ＴＭ５；１７７−１９９
（Ｓ）、ＴＭ６；２０６−２２７（Ｐ）］ olfactory receptor 2 [Gallus gallus] (X94742)；106
/233 (45%) 配列番号２９８［ＴＭ１；２６−４８（Ｐ）、ＴＭ２；
６２−８４（Ｓ）、ＴＭ３；１０４−１２６（Ｐ）、Ｔ
Ｍ４；１４２−１６４（Ｐ）、ＴＭ５；２０７−２２８
（Ｐ）、ＴＭ６；２７１−２９３（Ｓ）、ＴＭ７；３０
６−３２８（Ｐ）］ odorant receptor [Mus musculus] (X92969)；145/302
(48%) 配列番号３００［ＴＭ１；７−２９（Ｓ）、ＴＭ２；５
３−７５（Ｐ）、ＴＭ３；１０１−１２３（Ｓ）、ＴＭ
４；１３２−１５４（Ｓ）、ＴＭ５；１６３−１８５
（Ｐ）、ＴＭ６；１９８−２２０（Ｓ）］ dJ88J8.1 (novel 7 transmembrane receptor (rhodopsi
n family) (olfactory receptor like) protein) (hs6M
1-15)) [Homo sapiens] (AL035402)；173/261 (66%)
【００７２】配列番号３０２［ＴＭ１；１９−４１
（Ｓ）、ＴＭ２；８３−１０５（Ｓ）、ＴＭ３；１６４
−１８６（Ｓ）、ＴＭ４；２０３−２２５（Ｐ）、ＴＭ
５；２３９−２６０（Ｓ）、ＴＭ６；２７２−２９３
（Ｓ）］ olfactory receptor [Homo sapiens] (Z98744)；253/31
0 (81%) 配列番号３０４［ＴＭ１；８−３０（Ｓ）、ＴＭ２；５
１−７３（Ｓ）、ＴＭ３；９４−１１６（Ｐ）、ＴＭ
４；１７２−１９４（Ｐ）、ＴＭ５；２０１−２２３
（Ｓ）、ＴＭ６；２３２−２５４（Ｓ）］ olfactory receptor 4 [Gallus gallus] (X94744)；126
/267 (47%) 配列番号３０６［ＴＭ１；３２−５４（Ｐ）、ＴＭ２；
６２−８４（Ｓ）、ＴＭ３；１３４−１５６（Ｐ）、Ｔ
Ｍ４；２０６−２２８（Ｐ）、ＴＭ５；２４５−２６７
（Ｓ）、ＴＭ６；２７６−２９８（Ｓ）］ chi ck olfactory receptor 4 [Gallus gallus] (Z7959
3)；154/309 (49%) 配列番号３０８［ＴＭ１；４１−６３（Ｐ）、ＴＭ２；
７３−９５（Ｓ）、ＴＭ３；１０６−１２８（Ｓ）、Ｔ
Ｍ４；１４７−１６９（Ｐ）、ＴＭ５；２１９−２４１
（Ｐ）、ＴＭ６；２８７−３０９（Ｓ）］ HsOLF1 [Homo sapiens] (U56420)；146/310 (47%) 配列番号３１０［ＴＭ１；１１−３３（Ｓ）、ＴＭ２；
４２−６４（Ｐ）、ＴＭ３；７５−９７（Ｓ）、ＴＭ
４；１０６−１２８（Ｓ）、ＴＭ５；１５１−１７３
（Ｓ）、ＴＭ６；１８８−２１０（Ｓ）、ＴＭ７；２１
４−２３６（Ｐ）、ＴＭ８；２４９−２７０（Ｓ）］ olfactory receptor P2 [Mus musculus] (AF247657)；2
76/315 (87%)
（Ｓ）、ＴＭ２；８３−１０５（Ｓ）、ＴＭ３；１６４
−１８６（Ｓ）、ＴＭ４；２０３−２２５（Ｐ）、ＴＭ
５；２３９−２６０（Ｓ）、ＴＭ６；２７２−２９３
（Ｓ）］ olfactory receptor [Homo sapiens] (Z98744)；253/31
0 (81%) 配列番号３０４［ＴＭ１；８−３０（Ｓ）、ＴＭ２；５
１−７３（Ｓ）、ＴＭ３；９４−１１６（Ｐ）、ＴＭ
４；１７２−１９４（Ｐ）、ＴＭ５；２０１−２２３
（Ｓ）、ＴＭ６；２３２−２５４（Ｓ）］ olfactory receptor 4 [Gallus gallus] (X94744)；126
/267 (47%) 配列番号３０６［ＴＭ１；３２−５４（Ｐ）、ＴＭ２；
６２−８４（Ｓ）、ＴＭ３；１３４−１５６（Ｐ）、Ｔ
Ｍ４；２０６−２２８（Ｐ）、ＴＭ５；２４５−２６７
（Ｓ）、ＴＭ６；２７６−２９８（Ｓ）］ chi ck olfactory receptor 4 [Gallus gallus] (Z7959
3)；154/309 (49%) 配列番号３０８［ＴＭ１；４１−６３（Ｐ）、ＴＭ２；
７３−９５（Ｓ）、ＴＭ３；１０６−１２８（Ｓ）、Ｔ
Ｍ４；１４７−１６９（Ｐ）、ＴＭ５；２１９−２４１
（Ｐ）、ＴＭ６；２８７−３０９（Ｓ）］ HsOLF1 [Homo sapiens] (U56420)；146/310 (47%) 配列番号３１０［ＴＭ１；１１−３３（Ｓ）、ＴＭ２；
４２−６４（Ｐ）、ＴＭ３；７５−９７（Ｓ）、ＴＭ
４；１０６−１２８（Ｓ）、ＴＭ５；１５１−１７３
（Ｓ）、ＴＭ６；１８８−２１０（Ｓ）、ＴＭ７；２１
４−２３６（Ｐ）、ＴＭ８；２４９−２７０（Ｓ）］ olfactory receptor P2 [Mus musculus] (AF247657)；2
76/315 (87%)
【００７３】配列番号３１２［ＴＭ１；１５−３７
（Ｓ）、ＴＭ２；５３−７５（Ｓ）、ＴＭ３；８４−１
０６（Ｓ）、ＴＭ４；１０９−１３１（Ｐ）、ＴＭ５；
１６１−１８３（Ｐ）、ＴＭ６；１９６−２１８
（Ｐ）］ olfactory receptor [Homo sapiens] (AF065870)；246/
284 (86%) 配列番号３１４［ＴＭ１；２６−４８（Ｐ）、ＴＭ２；
６０−８２（Ｓ）、ＴＭ３；９９−１２０（Ｐ）、ＴＭ
４；１４２−１６４（Ｓ）、ＴＭ５；１７４−１９５
（Ｓ）、ＴＭ６；２０２−２２４（Ｐ）、ＴＭ７；２３
７−２５８（Ｐ）、ＴＭ８；２７１−２９２（Ｓ）］ dJ80I19.1 (olfactory receptor-like protein (hs6M1-
1)) [Homo sapiens] (AL022727)；136/305 (44%) 配列番号３１６［ＴＭ１；１０−３２（Ｓ）、ＴＭ２；
４６−６８（Ｐ）、ＴＭ３；８０−１０２（Ｐ）、ＴＭ
４；１１７−１３９（Ｐ）、ＴＭ５；１５７−１７９
（Ｐ）、ＴＭ６；２２２−２４４（Ｐ）、ＴＭ７；２５
９−２８１（Ｐ）］ odorant receptor S19 [Mus musculus] (AF121976)；16
8/291 (57%) 配列番号３１８［ＴＭ１；２−２４（Ｓ）、ＴＭ２；４
５−６７（Ｐ）、ＴＭ３；７２−９４（Ｐ）、ＴＭ４；
１１９−１４１（Ｓ）、ＴＭ５；１７０−１９２
（Ｐ）、ＴＭ６；２２１−２４３（Ｐ）、ＴＭ７；２６
０−２８２（Ｐ）、ＴＭ８；２８８−３１０（Ｓ）］ odorant receptor S19 [Mus musculus] (AF121976)；16
3/280 (58%) 配列番号３２０［ＴＭ１；３６−５８（Ｐ）、ＴＭ２；
６５−８６（Ｓ）、ＴＭ３；９３−１１５（Ｐ）、ＴＭ
４；１３４−１５６（Ｓ）、ＴＭ５；１９５−２１７
（Ｐ）、ＴＭ６；２３６−２５７（Ｓ）］ olfactory receptor-like protein [Homo sapiens] (L3
5475)；280/316 (88%)
（Ｓ）、ＴＭ２；５３−７５（Ｓ）、ＴＭ３；８４−１
０６（Ｓ）、ＴＭ４；１０９−１３１（Ｐ）、ＴＭ５；
１６１−１８３（Ｐ）、ＴＭ６；１９６−２１８
（Ｐ）］ olfactory receptor [Homo sapiens] (AF065870)；246/
284 (86%) 配列番号３１４［ＴＭ１；２６−４８（Ｐ）、ＴＭ２；
６０−８２（Ｓ）、ＴＭ３；９９−１２０（Ｐ）、ＴＭ
４；１４２−１６４（Ｓ）、ＴＭ５；１７４−１９５
（Ｓ）、ＴＭ６；２０２−２２４（Ｐ）、ＴＭ７；２３
７−２５８（Ｐ）、ＴＭ８；２７１−２９２（Ｓ）］ dJ80I19.1 (olfactory receptor-like protein (hs6M1-
1)) [Homo sapiens] (AL022727)；136/305 (44%) 配列番号３１６［ＴＭ１；１０−３２（Ｓ）、ＴＭ２；
４６−６８（Ｐ）、ＴＭ３；８０−１０２（Ｐ）、ＴＭ
４；１１７−１３９（Ｐ）、ＴＭ５；１５７−１７９
（Ｐ）、ＴＭ６；２２２−２４４（Ｐ）、ＴＭ７；２５
９−２８１（Ｐ）］ odorant receptor S19 [Mus musculus] (AF121976)；16
8/291 (57%) 配列番号３１８［ＴＭ１；２−２４（Ｓ）、ＴＭ２；４
５−６７（Ｐ）、ＴＭ３；７２−９４（Ｐ）、ＴＭ４；
１１９−１４１（Ｓ）、ＴＭ５；１７０−１９２
（Ｐ）、ＴＭ６；２２１−２４３（Ｐ）、ＴＭ７；２６
０−２８２（Ｐ）、ＴＭ８；２８８−３１０（Ｓ）］ odorant receptor S19 [Mus musculus] (AF121976)；16
3/280 (58%) 配列番号３２０［ＴＭ１；３６−５８（Ｐ）、ＴＭ２；
６５−８６（Ｓ）、ＴＭ３；９３−１１５（Ｐ）、ＴＭ
４；１３４−１５６（Ｓ）、ＴＭ５；１９５−２１７
（Ｐ）、ＴＭ６；２３６−２５７（Ｓ）］ olfactory receptor-like protein [Homo sapiens] (L3
5475)；280/316 (88%)
【００７４】配列番号３２２［ＴＭ１；２８−５０
（Ｐ）、ＴＭ２；９６−１１８（Ｐ）、ＴＭ３；１４１
−１６３（Ｓ）、ＴＭ４；１７６−１９８（Ｓ）、ＴＭ
５；２０７−２２９（Ｐ）、ＴＭ６；２３９−２６０
（Ｓ）、ＴＭ７；２７３−２９４（Ｓ）］ olfactory receptor G3 [Mus musculus] (AF102535)；1
87/223 (83%) 配列番号３２４［ＴＭ１；４−２６（Ｐ）、ＴＭ２；５
４−７６（Ｓ）、ＴＭ３；８４−１０６（Ｐ）、ＴＭ
４；１４４−１６６（Ｐ）、ＴＭ５；１８９−２１１
（Ｓ）、ＴＭ６；２１４−２３５（Ｓ）］ odorant receptor S25 [Mus musculus] (AF121977)；18
0/251 (71%) 配列番号３２６［ＴＭ１；３４−５６（Ｐ）、ＴＭ２；
９７−１１９（Ｐ）、ＴＭ３；１４０−１６２（Ｐ）、
ＴＭ４；１７３−１９５（Ｓ）、ＴＭ５；２０２−２２
３（Ｐ）、ＴＭ６；２６６−２８８（Ｓ）］ odorant receptor S25 [Mus musculus] (AF121977)；18
9/310 (60%) 配列番号３２８［ＴＭ１；３３−５５（Ｐ）、ＴＭ２；
９８−１２０（Ｐ）、ＴＭ３；１４２−１６４（Ｓ）、
ＴＭ４；２０４−２２６（Ｐ）、ＴＭ５；２３９−２６
１（Ｓ）、ＴＭ６；２７１−２９３（Ｓ）］ olfactory receptor P2 [Mus musculus] (AF247657)；1
58/309 (51%) 配列番号３３０［ＴＭ１；１９−４１（Ｐ）、ＴＭ２；
６１−８３（Ｐ）、ＴＭ３；９５−１１７（Ｐ）、ＴＭ
４；１４１−１６３（Ｐ）、ＴＭ５；２０１−２２３
（Ｐ）、ＴＭ６；２３９−２６０（Ｓ）、ＴＭ７；２７
２−２９３（Ｓ）］ odorant receptor [Mus musculus] (X92969)；156/310
(50%)
（Ｐ）、ＴＭ２；９６−１１８（Ｐ）、ＴＭ３；１４１
−１６３（Ｓ）、ＴＭ４；１７６−１９８（Ｓ）、ＴＭ
５；２０７−２２９（Ｐ）、ＴＭ６；２３９−２６０
（Ｓ）、ＴＭ７；２７３−２９４（Ｓ）］ olfactory receptor G3 [Mus musculus] (AF102535)；1
87/223 (83%) 配列番号３２４［ＴＭ１；４−２６（Ｐ）、ＴＭ２；５
４−７６（Ｓ）、ＴＭ３；８４−１０６（Ｐ）、ＴＭ
４；１４４−１６６（Ｐ）、ＴＭ５；１８９−２１１
（Ｓ）、ＴＭ６；２１４−２３５（Ｓ）］ odorant receptor S25 [Mus musculus] (AF121977)；18
0/251 (71%) 配列番号３２６［ＴＭ１；３４−５６（Ｐ）、ＴＭ２；
９７−１１９（Ｐ）、ＴＭ３；１４０−１６２（Ｐ）、
ＴＭ４；１７３−１９５（Ｓ）、ＴＭ５；２０２−２２
３（Ｐ）、ＴＭ６；２６６−２８８（Ｓ）］ odorant receptor S25 [Mus musculus] (AF121977)；18
9/310 (60%) 配列番号３２８［ＴＭ１；３３−５５（Ｐ）、ＴＭ２；
９８−１２０（Ｐ）、ＴＭ３；１４２−１６４（Ｓ）、
ＴＭ４；２０４−２２６（Ｐ）、ＴＭ５；２３９−２６
１（Ｓ）、ＴＭ６；２７１−２９３（Ｓ）］ olfactory receptor P2 [Mus musculus] (AF247657)；1
58/309 (51%) 配列番号３３０［ＴＭ１；１９−４１（Ｐ）、ＴＭ２；
６１−８３（Ｐ）、ＴＭ３；９５−１１７（Ｐ）、ＴＭ
４；１４１−１６３（Ｐ）、ＴＭ５；２０１−２２３
（Ｐ）、ＴＭ６；２３９−２６０（Ｓ）、ＴＭ７；２７
２−２９３（Ｓ）］ odorant receptor [Mus musculus] (X92969)；156/310
(50%)
【００７５】配列番号３３２［ＴＭ１；１−２３
（Ｓ）、ＴＭ２；３３−５５（Ｐ）、ＴＭ３；８３−１
０５（Ｓ）、ＴＭ４；１１８−１３９（Ｐ）、ＴＭ５；
１６６−１８８（Ｐ）、ＴＭ６；２２６−２４８
（Ｐ）、ＴＭ７；２６０−２８２（Ｓ）、ＴＭ８；２９
２−３１３（Ｓ）］ HGMP07J [Homo sapiens] >gi|228481|prf||1804351C ol
factory receptor HGMP07J [Homo sapiens] (X64995)；
168/308 (54%) 配列番号３３４［ＴＭ１；３３−５５（Ｐ）、ＴＭ２；
１０４−１２６（Ｐ）、ＴＭ３；１４５−１６７
（Ｓ）、ＴＭ４；２０７−２２９（Ｐ）、ＴＭ５；２４
３−２６５（Ｐ）、ＴＭ６；２７６−２９８（Ｐ）］ olfactory receptor I7 [Mus musculus] (AF106007)；1
81/311 (58%) 配列番号３３６［ＴＭ１；２０−４２（Ｐ）、ＴＭ２；
６３−８５（Ｐ）、ＴＭ３；９６−１１８（Ｐ）、ＴＭ
４；１４５−１６７（Ｓ）、ＴＭ５；２０３−２２５
（Ｐ）、ＴＭ６；２３８−２５９（Ｓ）、ＴＭ７；２７
２−２９３（Ｓ）］ HGMP07J [Homo sapiens] >gi|228481|prf||1804351C ol
factory receptor HGMP07J [Homo sapiens] (X64995)；
160/300 (53%) 配列番号３３８［ＴＭ１；２５−４７（Ｐ）、ＴＭ２；
６１−８３（Ｓ）、ＴＭ３；１００−１２２（Ｐ）、Ｔ
Ｍ４；１４４−１６６（Ｐ）、ＴＭ５；１９８−２２０
（Ｐ）、ＴＭ６；２３６−２５８（Ｓ）、ＴＭ７；２６
９−２９１（Ｓ）］ odorant receptor MOR18 [Mus musculus] (AB030895)；
181/302 (59%) 配列番号３４０［ＴＭ１；１−２３（Ｓ）、ＴＭ２；２
５−４７（Ｐ）、ＴＭ３；５９−８１（Ｐ）、ＴＭ４；
９２−１１４（Ｓ）、ＴＭ５；１４３−１６５（Ｓ）、
ＴＭ６；２０４−２２６（Ｐ）、ＴＭ７；２３７−２５
９（Ｓ）、ＴＭ８；２６７−２８９（Ｓ）］ odorant receptor A16 [Mus musculus] (AB030896)；17
0/297 (57%)
（Ｓ）、ＴＭ２；３３−５５（Ｐ）、ＴＭ３；８３−１
０５（Ｓ）、ＴＭ４；１１８−１３９（Ｐ）、ＴＭ５；
１６６−１８８（Ｐ）、ＴＭ６；２２６−２４８
（Ｐ）、ＴＭ７；２６０−２８２（Ｓ）、ＴＭ８；２９
２−３１３（Ｓ）］ HGMP07J [Homo sapiens] >gi|228481|prf||1804351C ol
factory receptor HGMP07J [Homo sapiens] (X64995)；
168/308 (54%) 配列番号３３４［ＴＭ１；３３−５５（Ｐ）、ＴＭ２；
１０４−１２６（Ｐ）、ＴＭ３；１４５−１６７
（Ｓ）、ＴＭ４；２０７−２２９（Ｐ）、ＴＭ５；２４
３−２６５（Ｐ）、ＴＭ６；２７６−２９８（Ｐ）］ olfactory receptor I7 [Mus musculus] (AF106007)；1
81/311 (58%) 配列番号３３６［ＴＭ１；２０−４２（Ｐ）、ＴＭ２；
６３−８５（Ｐ）、ＴＭ３；９６−１１８（Ｐ）、ＴＭ
４；１４５−１６７（Ｓ）、ＴＭ５；２０３−２２５
（Ｐ）、ＴＭ６；２３８−２５９（Ｓ）、ＴＭ７；２７
２−２９３（Ｓ）］ HGMP07J [Homo sapiens] >gi|228481|prf||1804351C ol
factory receptor HGMP07J [Homo sapiens] (X64995)；
160/300 (53%) 配列番号３３８［ＴＭ１；２５−４７（Ｐ）、ＴＭ２；
６１−８３（Ｓ）、ＴＭ３；１００−１２２（Ｐ）、Ｔ
Ｍ４；１４４−１６６（Ｐ）、ＴＭ５；１９８−２２０
（Ｐ）、ＴＭ６；２３６−２５８（Ｓ）、ＴＭ７；２６
９−２９１（Ｓ）］ odorant receptor MOR18 [Mus musculus] (AB030895)；
181/302 (59%) 配列番号３４０［ＴＭ１；１−２３（Ｓ）、ＴＭ２；２
５−４７（Ｐ）、ＴＭ３；５９−８１（Ｐ）、ＴＭ４；
９２−１１４（Ｓ）、ＴＭ５；１４３−１６５（Ｓ）、
ＴＭ６；２０４−２２６（Ｐ）、ＴＭ７；２３７−２５
９（Ｓ）、ＴＭ８；２６７−２８９（Ｓ）］ odorant receptor A16 [Mus musculus] (AB030896)；17
0/297 (57%)
【００７６】配列番号３４２［ＴＭ１；２３−４５
（Ｐ）、ＴＭ２；８５−１０７（Ｓ）、ＴＭ３；１３６
−１５８（Ｐ）、ＴＭ４；１７１−１９３（Ｐ）、ＴＭ
５；１９６−２１７（Ｐ）、ＴＭ６；２３０−２５２
（Ｐ）、ＴＭ７；２５９−２８１（Ｓ）］ odorant receptor MOR18 [Mus musculus] (AB030895)；
184/297 (61%) 配列番号３４４［ＴＭ１；４−２６（Ｐ）、ＴＭ２；２
９−５１（Ｐ）、ＴＭ３；８７−１０９（Ｐ）、ＴＭ
４；１３２−１５４（Ｐ）、ＴＭ５；２００−２２２
（Ｐ）、ＴＭ６；２２９−２５０（Ｓ）］ olfactory receptor [Mus musculus] (AJ251154)；188/
308 (61%) 配列番号３４６［ＴＭ１；１０−３２（Ｓ）、ＴＭ２；
４２−６４（Ｐ）、ＴＭ３；７６−９８（Ｓ）、ＴＭ
４；１１５−１３７（Ｓ）、ＴＭ５；１５６−１７７
（Ｓ）、ＴＭ６；２１６−２３８（Ｓ）、ＴＭ７；２５
４−２７６（Ｓ）、ＴＭ８；２８８−３０９（Ｓ）］ olfactory receptor-like protein COR3'beta [Gallus
gallus] (L17432)；167/314 (53%) 配列番号３４８［ＴＭ１；２−２３（Ｓ）、ＴＭ２；２
９−５１（Ｓ）、ＴＭ３；６７−８９（Ｓ）、ＴＭ４；
１０２−１２４（Ｐ）、ＴＭ５；１６１−１８３
（Ｓ）、ＴＭ６；２０９−２３１（Ｓ）、ＴＭ７；２３
７−２５９（Ｓ）］ olfactory receptor [Homo sapiens] (Y10529)；193/27
0 (71%) 配列番号３５０［ＴＭ１；３８−６０（Ｐ）、ＴＭ２；
８１−１０３（Ｓ）、ＴＭ３；１１１−１３３（Ｐ）、
ＴＭ４；１５４−１７６（Ｓ）、ＴＭ５；２１８−２４
０（Ｐ）、ＴＭ６；２５４−２７６（Ｐ）、ＴＭ７；２
８８−３０９（Ｓ）］ olfactory receptor [Mus musculus domesticus] (AF07
3987)；183/216 (84%)
（Ｐ）、ＴＭ２；８５−１０７（Ｓ）、ＴＭ３；１３６
−１５８（Ｐ）、ＴＭ４；１７１−１９３（Ｐ）、ＴＭ
５；１９６−２１７（Ｐ）、ＴＭ６；２３０−２５２
（Ｐ）、ＴＭ７；２５９−２８１（Ｓ）］ odorant receptor MOR18 [Mus musculus] (AB030895)；
184/297 (61%) 配列番号３４４［ＴＭ１；４−２６（Ｐ）、ＴＭ２；２
９−５１（Ｐ）、ＴＭ３；８７−１０９（Ｐ）、ＴＭ
４；１３２−１５４（Ｐ）、ＴＭ５；２００−２２２
（Ｐ）、ＴＭ６；２２９−２５０（Ｓ）］ olfactory receptor [Mus musculus] (AJ251154)；188/
308 (61%) 配列番号３４６［ＴＭ１；１０−３２（Ｓ）、ＴＭ２；
４２−６４（Ｐ）、ＴＭ３；７６−９８（Ｓ）、ＴＭ
４；１１５−１３７（Ｓ）、ＴＭ５；１５６−１７７
（Ｓ）、ＴＭ６；２１６−２３８（Ｓ）、ＴＭ７；２５
４−２７６（Ｓ）、ＴＭ８；２８８−３０９（Ｓ）］ olfactory receptor-like protein COR3'beta [Gallus
gallus] (L17432)；167/314 (53%) 配列番号３４８［ＴＭ１；２−２３（Ｓ）、ＴＭ２；２
９−５１（Ｓ）、ＴＭ３；６７−８９（Ｓ）、ＴＭ４；
１０２−１２４（Ｐ）、ＴＭ５；１６１−１８３
（Ｓ）、ＴＭ６；２０９−２３１（Ｓ）、ＴＭ７；２３
７−２５９（Ｓ）］ olfactory receptor [Homo sapiens] (Y10529)；193/27
0 (71%) 配列番号３５０［ＴＭ１；３８−６０（Ｐ）、ＴＭ２；
８１−１０３（Ｓ）、ＴＭ３；１１１−１３３（Ｐ）、
ＴＭ４；１５４−１７６（Ｓ）、ＴＭ５；２１８−２４
０（Ｐ）、ＴＭ６；２５４−２７６（Ｐ）、ＴＭ７；２
８８−３０９（Ｓ）］ olfactory receptor [Mus musculus domesticus] (AF07
3987)；183/216 (84%)
【００７７】配列番号３５２［ＴＭ１；１−２３
（Ｓ）、ＴＭ２；３０−５２（Ｐ）、ＴＭ３；６４−８
６（Ｐ）、ＴＭ４；１０３−１２５（Ｓ）、ＴＭ５；１
４４−１６５（Ｐ）、ＴＭ６；２０８−２３０（Ｐ）、
ＴＭ７；２４２−２６４（Ｓ）、ＴＭ８；２７６−２９
７（Ｓ）］ odorant receptor S18 [Mus musculus] (AF121975)；21
9/305 (71%) 配列番号３５４［ＴＭ１；３８−６０（Ｐ）、ＴＭ２；
７１−９３（Ｐ）、ＴＭ３；１０７−１２９（Ｓ）、Ｔ
Ｍ４；１５２−１７４（Ｓ）、ＴＭ５；２１３−２３５
（Ｐ）、ＴＭ６；２４８−２７０（Ｓ）、ＴＭ７；２８
０−３０２（Ｓ）］ odorant receptor S19 [Mus musculus] (AF121976)；16
3/288 (56%) 配列番号３５６［ＴＭ１；２８−５０（Ｐ）、ＴＭ２；
７２−９４（Ｓ）、ＴＭ３；１１２−１３４（Ｐ）、Ｔ
Ｍ４；１４１−１６３（Ｓ）、ＴＭ５；２２１−２４３
（Ｐ）、ＴＭ６；２８６−３０８（Ｐ）、ＴＭ７；３２
６−３４７（Ｓ）、ＴＭ８；３５７−３７９（Ｓ）］ olfactory receptor C6 [Mus musculus] (AF102523)；1
38/308 (44%) 配列番号３５８［ＴＭ１；２９−５１（Ｐ）、ＴＭ２；
６６−８８（Ｐ）、ＴＭ３；１０６−１２８（Ｓ）、Ｔ
Ｍ４；１３２−１５４（Ｐ）、ＴＭ５；１９７−２１９
（Ｐ）、ＴＭ６；２３４−２５５（Ｓ）、ＴＭ７；２６
７−２８９（Ｓ）］ olfactory receptor C6 [Mus musculus] (AF102523)；1
40/310 (45%) 配列番号３６０［ＴＭ１；１−２３（Ｓ）、ＴＭ２；２
８−５０（Ｓ）、ＴＭ３；６４−８６（Ｐ）、ＴＭ４；
１００−１２２（Ｐ）、ＴＭ５；１６６−１８８
（Ｐ）、ＴＭ６；２０１−２２２（Ｓ）］ olfactory receptor C6 [Mus musculus] (AF102523)；1
00/215 (46%)
（Ｓ）、ＴＭ２；３０−５２（Ｐ）、ＴＭ３；６４−８
６（Ｐ）、ＴＭ４；１０３−１２５（Ｓ）、ＴＭ５；１
４４−１６５（Ｐ）、ＴＭ６；２０８−２３０（Ｐ）、
ＴＭ７；２４２−２６４（Ｓ）、ＴＭ８；２７６−２９
７（Ｓ）］ odorant receptor S18 [Mus musculus] (AF121975)；21
9/305 (71%) 配列番号３５４［ＴＭ１；３８−６０（Ｐ）、ＴＭ２；
７１−９３（Ｐ）、ＴＭ３；１０７−１２９（Ｓ）、Ｔ
Ｍ４；１５２−１７４（Ｓ）、ＴＭ５；２１３−２３５
（Ｐ）、ＴＭ６；２４８−２７０（Ｓ）、ＴＭ７；２８
０−３０２（Ｓ）］ odorant receptor S19 [Mus musculus] (AF121976)；16
3/288 (56%) 配列番号３５６［ＴＭ１；２８−５０（Ｐ）、ＴＭ２；
７２−９４（Ｓ）、ＴＭ３；１１２−１３４（Ｐ）、Ｔ
Ｍ４；１４１−１６３（Ｓ）、ＴＭ５；２２１−２４３
（Ｐ）、ＴＭ６；２８６−３０８（Ｐ）、ＴＭ７；３２
６−３４７（Ｓ）、ＴＭ８；３５７−３７９（Ｓ）］ olfactory receptor C6 [Mus musculus] (AF102523)；1
38/308 (44%) 配列番号３５８［ＴＭ１；２９−５１（Ｐ）、ＴＭ２；
６６−８８（Ｐ）、ＴＭ３；１０６−１２８（Ｓ）、Ｔ
Ｍ４；１３２−１５４（Ｐ）、ＴＭ５；１９７−２１９
（Ｐ）、ＴＭ６；２３４−２５５（Ｓ）、ＴＭ７；２６
７−２８９（Ｓ）］ olfactory receptor C6 [Mus musculus] (AF102523)；1
40/310 (45%) 配列番号３６０［ＴＭ１；１−２３（Ｓ）、ＴＭ２；２
８−５０（Ｓ）、ＴＭ３；６４−８６（Ｐ）、ＴＭ４；
１００−１２２（Ｐ）、ＴＭ５；１６６−１８８
（Ｐ）、ＴＭ６；２０１−２２２（Ｓ）］ olfactory receptor C6 [Mus musculus] (AF102523)；1
00/215 (46%)
【００７８】配列番号３６２［ＴＭ１；３２−５４
（Ｐ）、ＴＭ２；１０５−１２７（Ｐ）、ＴＭ３；１４
４−１６６（Ｐ）、ＴＭ４；１８５−２０７（Ｓ）、Ｔ
Ｍ５；２１０−２３１（Ｐ）、ＴＭ６；２４１−２６３
（Ｓ）、ＴＭ７；２７２−２９４（Ｓ）］ HsOLF1 [Homo sapiens] (U56420)；161/310 (51%) 配列番号３６４［ＴＭ１；１９−４１（Ｐ）、ＴＭ２；
６１−８３（Ｓ）、ＴＭ３；９０−１１２（Ｐ）、ＴＭ
４；１１６−１３８（Ｓ）、ＴＭ５；１４５−１６７
（Ｓ）、ＴＭ６；１７９−２０１（Ｓ）、ＴＭ７；２１
０−２３２（Ｐ）、ＴＭ８；２７０−２９２（Ｓ）］ HsOLF1 [Homo sapiens] (U56420)；168/307 (54%) 配列番号３６６［ＴＭ１；１９−４１（Ｓ）、ＴＭ２；
６０−８２（Ｓ）、ＴＭ３；９９−１２１（Ｓ）、ＴＭ
４；１４０−１６２（Ｐ）、ＴＭ５；２０６−２２７
（Ｐ）、ＴＭ６；２４３−２６４（Ｓ）、ＴＭ７；２７
３−２９３（Ｓ）］ CfOLF2 [Canis familiaris] (U53680)；175/308 (56%) 配列番号３６８［ＴＭ１；２９−５１（Ｐ）、ＴＭ２；
１０１−１２３（Ｐ）、ＴＭ３；１４４−１６６
（Ｓ）、ＴＭ４；２０６−２２７（Ｐ）、ＴＭ５；２４
０−２６２（Ｓ）、ＴＭ６；２７３−２９５（Ｓ）］ olfactory receptor OR93Ch [Pan troglodytes] (AF045
577)；162/313 (51%) 配列番号３７０［ＴＭ１；２３−４５（Ｐ）、ＴＭ２；
６６−８７（Ｓ）、ＴＭ３；９４−１１６（Ｓ）、ＴＭ
４；１３３−１５５（Ｓ）、ＴＭ５；２００−２２２
（Ｐ）、ＴＭ６；２４６−２６８（Ｓ）、ＴＭ７；２７
６−２９８（Ｓ）］ Cf OLF1 [Canis familiaris] (U53679)；153/299 (51%)
（Ｐ）、ＴＭ２；１０５−１２７（Ｐ）、ＴＭ３；１４
４−１６６（Ｐ）、ＴＭ４；１８５−２０７（Ｓ）、Ｔ
Ｍ５；２１０−２３１（Ｐ）、ＴＭ６；２４１−２６３
（Ｓ）、ＴＭ７；２７２−２９４（Ｓ）］ HsOLF1 [Homo sapiens] (U56420)；161/310 (51%) 配列番号３６４［ＴＭ１；１９−４１（Ｐ）、ＴＭ２；
６１−８３（Ｓ）、ＴＭ３；９０−１１２（Ｐ）、ＴＭ
４；１１６−１３８（Ｓ）、ＴＭ５；１４５−１６７
（Ｓ）、ＴＭ６；１７９−２０１（Ｓ）、ＴＭ７；２１
０−２３２（Ｐ）、ＴＭ８；２７０−２９２（Ｓ）］ HsOLF1 [Homo sapiens] (U56420)；168/307 (54%) 配列番号３６６［ＴＭ１；１９−４１（Ｓ）、ＴＭ２；
６０−８２（Ｓ）、ＴＭ３；９９−１２１（Ｓ）、ＴＭ
４；１４０−１６２（Ｐ）、ＴＭ５；２０６−２２７
（Ｐ）、ＴＭ６；２４３−２６４（Ｓ）、ＴＭ７；２７
３−２９３（Ｓ）］ CfOLF2 [Canis familiaris] (U53680)；175/308 (56%) 配列番号３６８［ＴＭ１；２９−５１（Ｐ）、ＴＭ２；
１０１−１２３（Ｐ）、ＴＭ３；１４４−１６６
（Ｓ）、ＴＭ４；２０６−２２７（Ｐ）、ＴＭ５；２４
０−２６２（Ｓ）、ＴＭ６；２７３−２９５（Ｓ）］ olfactory receptor OR93Ch [Pan troglodytes] (AF045
577)；162/313 (51%) 配列番号３７０［ＴＭ１；２３−４５（Ｐ）、ＴＭ２；
６６−８７（Ｓ）、ＴＭ３；９４−１１６（Ｓ）、ＴＭ
４；１３３−１５５（Ｓ）、ＴＭ５；２００−２２２
（Ｐ）、ＴＭ６；２４６−２６８（Ｓ）、ＴＭ７；２７
６−２９８（Ｓ）］ Cf OLF1 [Canis familiaris] (U53679)；153/299 (51%)
【００７９】配列番号３７２［ＴＭ１；４１−６３
（Ｐ）、ＴＭ２；１０２−１２４（Ｓ）、ＴＭ３；１３
７−１５９（Ｐ）、ＴＭ４；２０７−２２９（Ｐ）、Ｔ
Ｍ５；２４６−２６８（Ｐ）、ＴＭ６；２７８−３００
（Ｐ）］ HsOLF1 [Homo sapiens] (U56420)；173/306 (56%) 配列番号３７４［ＴＭ１；７−２９（Ｓ）、ＴＭ２；３
２−５３（Ｐ）、ＴＭ３；６０−８２（Ｓ）、ＴＭ４；
１００−１２２（Ｓ）、ＴＭ５；１４４−１６６
（Ｐ）、ＴＭ６；２００−２２２（Ｐ）、ＴＭ７；２３
５−２５７（Ｓ）］ similar to rat olfactory receptor OR18; similar to
S29710 (PID:g423702)[Homo sapiens] (AC004908)；22
0/311 (70%) 配列番号３７６［ＴＭ１；１−２３（Ｓ）、ＴＭ２；２
８−５０（Ｐ）、ＴＭ３；５９−８１（Ｓ）、ＴＭ４；
９５−１１７（Ｐ）、ＴＭ５；１４２−１６４（Ｐ）、
ＴＭ６；２０６−２２８（Ｐ）、ＴＭ７；２３９−２６
０（Ｐ）］ similar to rat olfactory receptor OR18; similar to
S29710 (PID:g423702)[Homo sapiens] (AC004908)；22
5/291 (77%) 配列番号３７８［ＴＭ１；９−３１（Ｓ）、ＴＭ２；１
２３−１４５（Ｐ）、ＴＭ３；１４８−１７０（Ｓ）、
ＴＭ４；１９２−２１４（Ｓ）、ＴＭ５；２３６−２５
８（Ｐ）、ＴＭ６；２９５−３１７（Ｐ）、ＴＭ７；３
３４−３５５（Ｐ）、ＴＭ８；３６７−３８９（Ｓ）］ olfactory receptor OR18 - rat(S29710)；204/302 (67
%) 配列番号３８０［ＴＭ１；９−３１（Ｓ）、ＴＭ２；３
４−５６（Ｐ）、ＴＭ３；６２−８４（Ｓ）、ＴＭ４；
９７−１１９（Ｓ）、ＴＭ５；１４４−１６６（Ｓ）、
ＴＭ６；２０５−２２７（Ｐ）、ＴＭ７；２４２−２６
３（Ｐ）、ＴＭ８；２７５−２９６（Ｐ）］ olfactory receptor 4 [Gallus gallus] (X94744)；173
/303 (57%)
（Ｐ）、ＴＭ２；１０２−１２４（Ｓ）、ＴＭ３；１３
７−１５９（Ｐ）、ＴＭ４；２０７−２２９（Ｐ）、Ｔ
Ｍ５；２４６−２６８（Ｐ）、ＴＭ６；２７８−３００
（Ｐ）］ HsOLF1 [Homo sapiens] (U56420)；173/306 (56%) 配列番号３７４［ＴＭ１；７−２９（Ｓ）、ＴＭ２；３
２−５３（Ｐ）、ＴＭ３；６０−８２（Ｓ）、ＴＭ４；
１００−１２２（Ｓ）、ＴＭ５；１４４−１６６
（Ｐ）、ＴＭ６；２００−２２２（Ｐ）、ＴＭ７；２３
５−２５７（Ｓ）］ similar to rat olfactory receptor OR18; similar to
S29710 (PID:g423702)[Homo sapiens] (AC004908)；22
0/311 (70%) 配列番号３７６［ＴＭ１；１−２３（Ｓ）、ＴＭ２；２
８−５０（Ｐ）、ＴＭ３；５９−８１（Ｓ）、ＴＭ４；
９５−１１７（Ｐ）、ＴＭ５；１４２−１６４（Ｐ）、
ＴＭ６；２０６−２２８（Ｐ）、ＴＭ７；２３９−２６
０（Ｐ）］ similar to rat olfactory receptor OR18; similar to
S29710 (PID:g423702)[Homo sapiens] (AC004908)；22
5/291 (77%) 配列番号３７８［ＴＭ１；９−３１（Ｓ）、ＴＭ２；１
２３−１４５（Ｐ）、ＴＭ３；１４８−１７０（Ｓ）、
ＴＭ４；１９２−２１４（Ｓ）、ＴＭ５；２３６−２５
８（Ｐ）、ＴＭ６；２９５−３１７（Ｐ）、ＴＭ７；３
３４−３５５（Ｐ）、ＴＭ８；３６７−３８９（Ｓ）］ olfactory receptor OR18 - rat(S29710)；204/302 (67
%) 配列番号３８０［ＴＭ１；９−３１（Ｓ）、ＴＭ２；３
４−５６（Ｐ）、ＴＭ３；６２−８４（Ｓ）、ＴＭ４；
９７−１１９（Ｓ）、ＴＭ５；１４４−１６６（Ｓ）、
ＴＭ６；２０５−２２７（Ｐ）、ＴＭ７；２４２−２６
３（Ｐ）、ＴＭ８；２７５−２９６（Ｐ）］ olfactory receptor 4 [Gallus gallus] (X94744)；173
/303 (57%)
【００８０】配列番号３８２［ＴＭ１；２０−４２
（Ｓ）、ＴＭ２；６２−８４（Ｓ）、ＴＭ３；９５−１
１７（Ｓ）、ＴＭ４；１４６−１６８（Ｓ）、ＴＭ５；
２０５−２２６（Ｐ）、ＴＭ６；２３７−２５９
（Ｓ）、ＴＭ７；２６８−２９０（Ｓ）］ odorant receptor MOR83 [Mus musculus] (AB030894)；
156/304 (51%) 配列番号３８４［ＴＭ１；２２−４４（Ｐ）、ＴＭ２；
６２−８４（Ｓ）、ＴＭ３；９８−１２０（Ｓ）、ＴＭ
４；１４４−１６６（Ｐ）、ＴＭ５；１９７−２１９
（Ｐ）、ＴＭ６；２３７−２５９（Ｓ）、ＴＭ７；２６
９−２９１（Ｓ）］ odorant receptor MOR83 [Mus musculus] (AB030894)；
159/304 (52%) 配列番号３８６［ＴＭ１；４９−７１（Ｐ）、ＴＭ２；
７７−９９（Ｓ）、ＴＭ３；１２０−１４２（Ｐ）、Ｔ
Ｍ４；１７３−１９５（Ｓ）、ＴＭ５；２２１−２４３
（Ｐ）、ＴＭ６；２６０−２８２（Ｐ）、ＴＭ７；２８
９−３１１（Ｐ）］ MOR 3'Beta1 [Mus musculus] (AF133300)；188/310 (60
%) 配列番号３８８［ＴＭ１；１７−３９（Ｐ）、ＴＭ２；
５０−７２（Ｓ）、ＴＭ３；８２−１０４（Ｐ）、ＴＭ
４；１３４−１５６（Ｓ）、ＴＭ５；１６７−１８９
（Ｓ）、ＴＭ６；１９６−２１７（Ｐ）、ＴＭ７；２２
４−２４５（Ｓ）］ olfactory receptor P2 [Mus musculus] (AF247657)；2
26/296 (76%) 配列番号３９０［ＴＭ１；１９−４１（Ｐ）、ＴＭ２；
６１−８３（Ｐ）、ＴＭ３；９４−１１６（Ｐ）、ＴＭ
４；１３６−１５８（Ｐ）、ＴＭ５；１７８−２００
（Ｓ）、ＴＭ６；２０７−２２９（Ｐ）、ＴＭ７；２７
３−２９５（Ｓ）］ o lfactory receptor P2 [Mus musculus] (AF247657)；
170/304 (55%)
（Ｓ）、ＴＭ２；６２−８４（Ｓ）、ＴＭ３；９５−１
１７（Ｓ）、ＴＭ４；１４６−１６８（Ｓ）、ＴＭ５；
２０５−２２６（Ｐ）、ＴＭ６；２３７−２５９
（Ｓ）、ＴＭ７；２６８−２９０（Ｓ）］ odorant receptor MOR83 [Mus musculus] (AB030894)；
156/304 (51%) 配列番号３８４［ＴＭ１；２２−４４（Ｐ）、ＴＭ２；
６２−８４（Ｓ）、ＴＭ３；９８−１２０（Ｓ）、ＴＭ
４；１４４−１６６（Ｐ）、ＴＭ５；１９７−２１９
（Ｐ）、ＴＭ６；２３７−２５９（Ｓ）、ＴＭ７；２６
９−２９１（Ｓ）］ odorant receptor MOR83 [Mus musculus] (AB030894)；
159/304 (52%) 配列番号３８６［ＴＭ１；４９−７１（Ｐ）、ＴＭ２；
７７−９９（Ｓ）、ＴＭ３；１２０−１４２（Ｐ）、Ｔ
Ｍ４；１７３−１９５（Ｓ）、ＴＭ５；２２１−２４３
（Ｐ）、ＴＭ６；２６０−２８２（Ｐ）、ＴＭ７；２８
９−３１１（Ｐ）］ MOR 3'Beta1 [Mus musculus] (AF133300)；188/310 (60
%) 配列番号３８８［ＴＭ１；１７−３９（Ｐ）、ＴＭ２；
５０−７２（Ｓ）、ＴＭ３；８２−１０４（Ｐ）、ＴＭ
４；１３４−１５６（Ｓ）、ＴＭ５；１６７−１８９
（Ｓ）、ＴＭ６；１９６−２１７（Ｐ）、ＴＭ７；２２
４−２４５（Ｓ）］ olfactory receptor P2 [Mus musculus] (AF247657)；2
26/296 (76%) 配列番号３９０［ＴＭ１；１９−４１（Ｐ）、ＴＭ２；
６１−８３（Ｐ）、ＴＭ３；９４−１１６（Ｐ）、ＴＭ
４；１３６−１５８（Ｐ）、ＴＭ５；１７８−２００
（Ｓ）、ＴＭ６；２０７−２２９（Ｐ）、ＴＭ７；２７
３−２９５（Ｓ）］ o lfactory receptor P2 [Mus musculus] (AF247657)；
170/304 (55%)
【００８１】配列番号３９２［ＴＭ１；２７−４９
（Ｐ）、ＴＭ２；６２−８４（Ｐ）、ＴＭ３；９５−１
１７（Ｐ）、ＴＭ４；１３５−１５７（Ｐ）、ＴＭ５；
１７７−１９９（Ｓ）、ＴＭ６；２０７−２２９
（Ｐ）、ＴＭ７；２７３−２９５（Ｓ）］ olfactory receptor P2 [Mus musculus] (AF247657)；1
64/304 (53%) 配列番号３９４［ＴＭ１；３０−５２（Ｐ）、ＴＭ２；
７４−９６（Ｐ）、ＴＭ３；１３７−１５７（Ｐ）、Ｔ
Ｍ４；１８３−２０５（Ｓ）、ＴＭ５；２５８−２８０
（Ｐ）、ＴＭ６；３２０−３４１（Ｓ）］ taste bud receptor protein TB 567 [Rattus norvegic
us] (U50948)；235/307(76%) 配列番号３９６［ＴＭ１；２４−４６（Ｐ）、ＴＭ２；
５６−７８（Ｓ）、ＴＭ３；９４−１１６（Ｓ）、ＴＭ
４；１２９−１５１（Ｐ）、ＴＭ５；２０７−２２９
（Ｐ）、ＴＭ６；２４１−２６３（Ｓ）、ＴＭ７；２７
２−２９２（Ｐ）］ olfactory receptor OR14 - rat(S29709)；256/304 (84
%) 配列番号３９８［ＴＭ１；２８−５０（Ｐ）、ＴＭ２；
９８−１２０（Ｐ）、ＴＭ３；１２７−１４９（Ｐ）、
ＴＭ４；２０３−２２５（Ｐ）、ＴＭ５；２４９−２７
１（Ｓ）、ＴＭ６；２７４−２９５（Ｓ）］ olfactory receptor OR14 - rat(S29709)；234/299 (78
%) 配列番号４００［ＴＭ１；３２−５４（Ｐ）、ＴＭ２；
５７−７９（Ｐ）、ＴＭ３；９２−１１４（Ｐ）、ＴＭ
４；１２９−１５１（Ｐ）、ＴＭ５；２０１−２２３
（Ｐ）、ＴＭ６；２３７−２５９（Ｓ）］ olfactory receptor OR14 - rat(S29709)；189/302 (62
%)
（Ｐ）、ＴＭ２；６２−８４（Ｐ）、ＴＭ３；９５−１
１７（Ｐ）、ＴＭ４；１３５−１５７（Ｐ）、ＴＭ５；
１７７−１９９（Ｓ）、ＴＭ６；２０７−２２９
（Ｐ）、ＴＭ７；２７３−２９５（Ｓ）］ olfactory receptor P2 [Mus musculus] (AF247657)；1
64/304 (53%) 配列番号３９４［ＴＭ１；３０−５２（Ｐ）、ＴＭ２；
７４−９６（Ｐ）、ＴＭ３；１３７−１５７（Ｐ）、Ｔ
Ｍ４；１８３−２０５（Ｓ）、ＴＭ５；２５８−２８０
（Ｐ）、ＴＭ６；３２０−３４１（Ｓ）］ taste bud receptor protein TB 567 [Rattus norvegic
us] (U50948)；235/307(76%) 配列番号３９６［ＴＭ１；２４−４６（Ｐ）、ＴＭ２；
５６−７８（Ｓ）、ＴＭ３；９４−１１６（Ｓ）、ＴＭ
４；１２９−１５１（Ｐ）、ＴＭ５；２０７−２２９
（Ｐ）、ＴＭ６；２４１−２６３（Ｓ）、ＴＭ７；２７
２−２９２（Ｐ）］ olfactory receptor OR14 - rat(S29709)；256/304 (84
%) 配列番号３９８［ＴＭ１；２８−５０（Ｐ）、ＴＭ２；
９８−１２０（Ｐ）、ＴＭ３；１２７−１４９（Ｐ）、
ＴＭ４；２０３−２２５（Ｐ）、ＴＭ５；２４９−２７
１（Ｓ）、ＴＭ６；２７４−２９５（Ｓ）］ olfactory receptor OR14 - rat(S29709)；234/299 (78
%) 配列番号４００［ＴＭ１；３２−５４（Ｐ）、ＴＭ２；
５７−７９（Ｐ）、ＴＭ３；９２−１１４（Ｐ）、ＴＭ
４；１２９−１５１（Ｐ）、ＴＭ５；２０１−２２３
（Ｐ）、ＴＭ６；２３７−２５９（Ｓ）］ olfactory receptor OR14 - rat(S29709)；189/302 (62
%)
【００８２】配列番号４０２［ＴＭ１；３０−５２
（Ｐ）、ＴＭ２；６２−８４（Ｓ）、ＴＭ３；９４−１
１６（Ｐ）、ＴＭ４；１３８−１５９（Ｐ）、ＴＭ５；
２０３−２２５（Ｐ）、ＴＭ６；２３８−２５９
（Ｓ）、ＴＭ７；２７２−２９３（Ｓ）］ olfactory receptor [Rattus norvegicus] (X80671)；2
10/305 (68%) 配列番号４０４［ＴＭ１；２６−４８（Ｐ）、ＴＭ２；
９４−１１６（Ｓ）、ＴＭ３；１２９−１５１（Ｓ）、
ＴＭ４；１８１−２０３（Ｐ）、ＴＭ５；２０８−２２
９（Ｐ）、ＴＭ６；２４０−２６２（Ｓ）、ＴＭ７；２
７１−２９２（Ｓ）］ olfactory receptor OR14 - rat(S29709)；201/300 (67
%) 配列番号４０６［ＴＭ１；２８−５０（Ｐ）、ＴＭ２；
６３−８５（Ｓ）、ＴＭ３；９３−１１５（Ｐ）、ＴＭ
４；１３０−１５２（Ｐ）、ＴＭ５；２０２−２２４
（Ｐ）、ＴＭ６；２３８−２５９（Ｐ）］ olfactory receptor [Rattus norvegicus] (X80671)；2
47/302 (81%) 配列番号４０８［ＴＭ１；１−２１（Ｓ）、ＴＭ２；４
０−６２（Ｐ）、ＴＭ３；９８−１２０（Ｐ）、ＴＭ
４；２２３−２４５（Ｐ）、ＴＭ５；２６０−２８２
（Ｓ）、ＴＭ６；２９０−３１２（Ｓ）］ taste bud receptor protein TB 641 [Rattus norvegic
us] (U50949)；185/297(62%) 配列番号４１０［ＴＭ１；２０−４２（Ｐ）、ＴＭ２；
２００−２２２（Ｐ）、ＴＭ３；２３９−２６１
（Ｐ）、ＴＭ４；２６９−２９０（Ｓ）、ＴＭ５；３０
４−３２６（Ｐ）、ＴＭ６；３３１−３５２（Ｐ）、Ｔ
Ｍ７；３５８−３７２（Ｓ）］ taste bud receptor protein TB 641 [Rattus norvegic
us] (U50949)；170/302(56%)
（Ｐ）、ＴＭ２；６２−８４（Ｓ）、ＴＭ３；９４−１
１６（Ｐ）、ＴＭ４；１３８−１５９（Ｐ）、ＴＭ５；
２０３−２２５（Ｐ）、ＴＭ６；２３８−２５９
（Ｓ）、ＴＭ７；２７２−２９３（Ｓ）］ olfactory receptor [Rattus norvegicus] (X80671)；2
10/305 (68%) 配列番号４０４［ＴＭ１；２６−４８（Ｐ）、ＴＭ２；
９４−１１６（Ｓ）、ＴＭ３；１２９−１５１（Ｓ）、
ＴＭ４；１８１−２０３（Ｐ）、ＴＭ５；２０８−２２
９（Ｐ）、ＴＭ６；２４０−２６２（Ｓ）、ＴＭ７；２
７１−２９２（Ｓ）］ olfactory receptor OR14 - rat(S29709)；201/300 (67
%) 配列番号４０６［ＴＭ１；２８−５０（Ｐ）、ＴＭ２；
６３−８５（Ｓ）、ＴＭ３；９３−１１５（Ｐ）、ＴＭ
４；１３０−１５２（Ｐ）、ＴＭ５；２０２−２２４
（Ｐ）、ＴＭ６；２３８−２５９（Ｐ）］ olfactory receptor [Rattus norvegicus] (X80671)；2
47/302 (81%) 配列番号４０８［ＴＭ１；１−２１（Ｓ）、ＴＭ２；４
０−６２（Ｐ）、ＴＭ３；９８−１２０（Ｐ）、ＴＭ
４；２２３−２４５（Ｐ）、ＴＭ５；２６０−２８２
（Ｓ）、ＴＭ６；２９０−３１２（Ｓ）］ taste bud receptor protein TB 641 [Rattus norvegic
us] (U50949)；185/297(62%) 配列番号４１０［ＴＭ１；２０−４２（Ｐ）、ＴＭ２；
２００−２２２（Ｐ）、ＴＭ３；２３９−２６１
（Ｐ）、ＴＭ４；２６９−２９０（Ｓ）、ＴＭ５；３０
４−３２６（Ｐ）、ＴＭ６；３３１−３５２（Ｐ）、Ｔ
Ｍ７；３５８−３７２（Ｓ）］ taste bud receptor protein TB 641 [Rattus norvegic
us] (U50949)；170/302(56%)
【００８３】配列番号４１２［ＴＭ１；１−２３
（Ｓ）、ＴＭ２；２６−４８（Ｓ）、ＴＭ３；１１０−
１３２（Ｓ）、ＴＭ４；１３７−１５８（Ｐ）、ＴＭ
５；１７０−１９２（Ｐ）、ＴＭ６；１９８−２２０
（Ｓ）］ taste bud receptor protein TB 641 [Rattus norvegic
us] (U50949)；140/234(59%) 配列番号４１４［ＴＭ１；３−２５（Ｓ）、ＴＭ２；３
０−５２（Ｐ）、ＴＭ３；６３−８５（Ｓ）、ＴＭ４；
１８０−２０２（Ｓ）、ＴＭ５；２０５−２２６
（Ｐ）、ＴＭ６；２３９−２６１（Ｐ）、ＴＭ７；２６
６−２８８（Ｓ）］ taste bud receptor protein TB 641 [Rattus norvegic
us] (U50949)；165/299(55%) 配列番号４１６［ＴＭ１；６−２８（Ｓ）、ＴＭ２；４
１−６３（Ｓ）、ＴＭ３；１０２−１２４（Ｐ）、ＴＭ
４；１４２−１６４（Ｐ）、ＴＭ５；１７０−１９２
（Ｓ）、ＴＭ６；１９８−２２０（Ｓ）］ olfactory receptor OR18 - rat(S29710)；154/209 (73
%) 配列番号４１８［ＴＭ１；２６−４８（Ｓ）、ＴＭ２；
９９−１２１（Ｐ）、ＴＭ３；１４１−１６３（Ｐ）、
ＴＭ４；２０４−２２６（Ｐ）、ＴＭ５；２３５−２５
６（Ｐ）、ＴＭ６；２６７−２８９（Ｓ）、ＴＭ７；３
０５−３２７（Ｐ）］ odorant receptor A16 [Mus musculus] (AB030896)；16
4/286 (57%) 配列番号４２０［ＴＭ１；３３−５５（Ｐ）、ＴＭ２；
７０−９２（Ｓ）、ＴＭ３；１０３−１２５（Ｐ）、Ｔ
Ｍ４；２０９−２３１（Ｐ）、ＴＭ５；２４７−２６９
（Ｓ）、ＴＭ６；２７８−３００（Ｓ）］ olfactory receptor 4 [Gallus gallus] (X94744)；159
/306 (51%)
（Ｓ）、ＴＭ２；２６−４８（Ｓ）、ＴＭ３；１１０−
１３２（Ｓ）、ＴＭ４；１３７−１５８（Ｐ）、ＴＭ
５；１７０−１９２（Ｐ）、ＴＭ６；１９８−２２０
（Ｓ）］ taste bud receptor protein TB 641 [Rattus norvegic
us] (U50949)；140/234(59%) 配列番号４１４［ＴＭ１；３−２５（Ｓ）、ＴＭ２；３
０−５２（Ｐ）、ＴＭ３；６３−８５（Ｓ）、ＴＭ４；
１８０−２０２（Ｓ）、ＴＭ５；２０５−２２６
（Ｐ）、ＴＭ６；２３９−２６１（Ｐ）、ＴＭ７；２６
６−２８８（Ｓ）］ taste bud receptor protein TB 641 [Rattus norvegic
us] (U50949)；165/299(55%) 配列番号４１６［ＴＭ１；６−２８（Ｓ）、ＴＭ２；４
１−６３（Ｓ）、ＴＭ３；１０２−１２４（Ｐ）、ＴＭ
４；１４２−１６４（Ｐ）、ＴＭ５；１７０−１９２
（Ｓ）、ＴＭ６；１９８−２２０（Ｓ）］ olfactory receptor OR18 - rat(S29710)；154/209 (73
%) 配列番号４１８［ＴＭ１；２６−４８（Ｓ）、ＴＭ２；
９９−１２１（Ｐ）、ＴＭ３；１４１−１６３（Ｐ）、
ＴＭ４；２０４−２２６（Ｐ）、ＴＭ５；２３５−２５
６（Ｐ）、ＴＭ６；２６７−２８９（Ｓ）、ＴＭ７；３
０５−３２７（Ｐ）］ odorant receptor A16 [Mus musculus] (AB030896)；16
4/286 (57%) 配列番号４２０［ＴＭ１；３３−５５（Ｐ）、ＴＭ２；
７０−９２（Ｓ）、ＴＭ３；１０３−１２５（Ｐ）、Ｔ
Ｍ４；２０９−２３１（Ｐ）、ＴＭ５；２４７−２６９
（Ｓ）、ＴＭ６；２７８−３００（Ｓ）］ olfactory receptor 4 [Gallus gallus] (X94744)；159
/306 (51%)
【００８４】配列番号４２２［ＴＭ１；６−２８
（Ｓ）、ＴＭ２；３１−５２（Ｐ）、ＴＭ３；９１−１
１３（Ｐ）、ＴＭ４；１３７−１５９（Ｓ）、ＴＭ５；
２０１−２２３（Ｐ）、ＴＭ６；２３９−２６１
（Ｓ）、ＴＭ７；２７０−２９２（Ｓ）］ olfactory receptor OR93Ch [Pan troglodytes] (AF045
577)；166/305 (54%) 配列番号４２４［ＴＭ１；２４−４６（Ｐ）、ＴＭ２；
９９−１２０（Ｐ）、ＴＭ３；１３７−１５９（Ｐ）、
ＴＭ４；２０４−２２５（Ｐ）、ＴＭ５；２３７−２５
８（Ｓ）、ＴＭ６；２７０−２９１（Ｓ）］ HsOLF1 [Homo sapiens] (U56420)；154/301 (51%) 配列番号４２６［ＴＭ１；１７−３９（Ｓ）、ＴＭ２；
７２−９４（Ｓ）、ＴＭ３；１３４−１５６（Ｐ）、Ｔ
Ｍ４；２０３−２２４（Ｐ）、ＴＭ５；２３８−２６０
（Ｐ）、ＴＭ６；２６９−２９１（Ｓ）］ olfactory receptor 2 [Gallus gallus] (X94742)；155
/307 (50%) 配列番号４２８［ＴＭ１；２６−４８（Ｐ）、ＴＭ２；
５５−７７（Ｓ）、ＴＭ３；８１−１０３（Ｓ）、ＴＭ
４；１４１−１６３（Ｐ）、ＴＭ５；１９７−２１９
（Ｐ）、ＴＭ６；２３８−２６０（Ｐ）、ＴＭ７；２６
８−２９０（Ｓ）］ olfactory receptor OR18 - rat(S29710)；193/299 (64
%) 配列番号４３０［ＴＭ１；３５−５７（Ｓ）、ＴＭ２；
９６−１１８（Ｓ）、ＴＭ３；１３０−１５２（Ｐ）、
ＴＭ４；１５６−１７８（Ｓ）、ＴＭ５；１９３−２１
５（Ｐ）、ＴＭ６；２３９−２６１（Ｐ）、ＴＭ７；２
６６−２８８（Ｓ）、ＴＭ８；２９４−３１５（Ｓ）］ olfactory receptor OR18 - rat(S29710)；213/304 (70
%)
（Ｓ）、ＴＭ２；３１−５２（Ｐ）、ＴＭ３；９１−１
１３（Ｐ）、ＴＭ４；１３７−１５９（Ｓ）、ＴＭ５；
２０１−２２３（Ｐ）、ＴＭ６；２３９−２６１
（Ｓ）、ＴＭ７；２７０−２９２（Ｓ）］ olfactory receptor OR93Ch [Pan troglodytes] (AF045
577)；166/305 (54%) 配列番号４２４［ＴＭ１；２４−４６（Ｐ）、ＴＭ２；
９９−１２０（Ｐ）、ＴＭ３；１３７−１５９（Ｐ）、
ＴＭ４；２０４−２２５（Ｐ）、ＴＭ５；２３７−２５
８（Ｓ）、ＴＭ６；２７０−２９１（Ｓ）］ HsOLF1 [Homo sapiens] (U56420)；154/301 (51%) 配列番号４２６［ＴＭ１；１７−３９（Ｓ）、ＴＭ２；
７２−９４（Ｓ）、ＴＭ３；１３４−１５６（Ｐ）、Ｔ
Ｍ４；２０３−２２４（Ｐ）、ＴＭ５；２３８−２６０
（Ｐ）、ＴＭ６；２６９−２９１（Ｓ）］ olfactory receptor 2 [Gallus gallus] (X94742)；155
/307 (50%) 配列番号４２８［ＴＭ１；２６−４８（Ｐ）、ＴＭ２；
５５−７７（Ｓ）、ＴＭ３；８１−１０３（Ｓ）、ＴＭ
４；１４１−１６３（Ｐ）、ＴＭ５；１９７−２１９
（Ｐ）、ＴＭ６；２３８−２６０（Ｐ）、ＴＭ７；２６
８−２９０（Ｓ）］ olfactory receptor OR18 - rat(S29710)；193/299 (64
%) 配列番号４３０［ＴＭ１；３５−５７（Ｓ）、ＴＭ２；
９６−１１８（Ｓ）、ＴＭ３；１３０−１５２（Ｐ）、
ＴＭ４；１５６−１７８（Ｓ）、ＴＭ５；１９３−２１
５（Ｐ）、ＴＭ６；２３９−２６１（Ｐ）、ＴＭ７；２
６６−２８８（Ｓ）、ＴＭ８；２９４−３１５（Ｓ）］ olfactory receptor OR18 - rat(S29710)；213/304 (70
%)
【００８５】配列番号４３２［ＴＭ１；１０−３２
（Ｓ）、ＴＭ２；６３−８５（Ｐ）、ＴＭ３；１０１−
１２３（Ｓ）、ＴＭ４；１５８−１８０（Ｐ）、ＴＭ
５；１９４−２１６（Ｐ）、ＴＭ６；２２９−２４９
（Ｓ）］ olfactory receptor [Rattus norvegicus] (AF01029
3)；198/263 (75%) 配列番号４３４［ＴＭ１；１６−３８（Ｐ）、ＴＭ２；
５６−７８（Ｓ）、ＴＭ３；８６−１０８（Ｐ）、ＴＭ
４；１３９−１６１（Ｐ）、ＴＭ５；１９７−２１９
（Ｐ）、ＴＭ６；２３８−２６０（Ｓ）、ＴＭ７；２７
０−２９１（Ｓ）］ olfactory protein [Rattus norvegicus] (M64378)；14
2/294 (48%) 配列番号４３６［ＴＭ１；８−３０（Ｐ）、ＴＭ２；６
０−８２（Ｓ）、ＴＭ３；９３−１１５（Ｐ）、ＴＭ
４；１３９−１６１（Ｐ）、ＴＭ５；２０３−２２５
（Ｐ）、ＴＭ６；２６８−２９０（Ｓ）］ olfactory receptor C6 [Mus musculus] (AF102523)；1
49/312 (47%) 配列番号４３８［ＴＭ１；２１−４３（Ｐ）、ＴＭ２；
８９−１１１（Ｓ）、ＴＭ３；１３２−１５４（Ｓ）、
ＴＭ４；１９９−２２１（Ｐ）、ＴＭ５；２３９−２６
０（Ｓ）、ＴＭ６；２６９−２９１（Ｓ）］ olfactory receptor 2 [Gallus gallus] (X94742)；148
/304 (48%) 配列番号４４０［ＴＭ１；３４−５６（Ｐ）、ＴＭ２；
６２−８４（Ｐ）、ＴＭ３；８８−１１０（Ｓ）、ＴＭ
４；２０６−２２８（Ｐ）、ＴＭ５；２３８−２６０
（Ｐ）、ＴＭ６；２７０−２９１（Ｓ）］ olfactory receptor 2 [Gallus gallus] (X94742)；158
/307 (51%)
（Ｓ）、ＴＭ２；６３−８５（Ｐ）、ＴＭ３；１０１−
１２３（Ｓ）、ＴＭ４；１５８−１８０（Ｐ）、ＴＭ
５；１９４−２１６（Ｐ）、ＴＭ６；２２９−２４９
（Ｓ）］ olfactory receptor [Rattus norvegicus] (AF01029
3)；198/263 (75%) 配列番号４３４［ＴＭ１；１６−３８（Ｐ）、ＴＭ２；
５６−７８（Ｓ）、ＴＭ３；８６−１０８（Ｐ）、ＴＭ
４；１３９−１６１（Ｐ）、ＴＭ５；１９７−２１９
（Ｐ）、ＴＭ６；２３８−２６０（Ｓ）、ＴＭ７；２７
０−２９１（Ｓ）］ olfactory protein [Rattus norvegicus] (M64378)；14
2/294 (48%) 配列番号４３６［ＴＭ１；８−３０（Ｐ）、ＴＭ２；６
０−８２（Ｓ）、ＴＭ３；９３−１１５（Ｐ）、ＴＭ
４；１３９−１６１（Ｐ）、ＴＭ５；２０３−２２５
（Ｐ）、ＴＭ６；２６８−２９０（Ｓ）］ olfactory receptor C6 [Mus musculus] (AF102523)；1
49/312 (47%) 配列番号４３８［ＴＭ１；２１−４３（Ｐ）、ＴＭ２；
８９−１１１（Ｓ）、ＴＭ３；１３２−１５４（Ｓ）、
ＴＭ４；１９９−２２１（Ｐ）、ＴＭ５；２３９−２６
０（Ｓ）、ＴＭ６；２６９−２９１（Ｓ）］ olfactory receptor 2 [Gallus gallus] (X94742)；148
/304 (48%) 配列番号４４０［ＴＭ１；３４−５６（Ｐ）、ＴＭ２；
６２−８４（Ｐ）、ＴＭ３；８８−１１０（Ｓ）、ＴＭ
４；２０６−２２８（Ｐ）、ＴＭ５；２３８−２６０
（Ｐ）、ＴＭ６；２７０−２９１（Ｓ）］ olfactory receptor 2 [Gallus gallus] (X94742)；158
/307 (51%)
【００８６】配列番号４４２［ＴＭ１；２３−４５
（Ｓ）、ＴＭ２；７６−９８（Ｓ）、ＴＭ３；１３４−
１５６（Ｓ）、ＴＭ４；１９９−２２１（Ｐ）、ＴＭ
５；２４０−２６１（Ｓ）、ＴＭ６；２７０−２９１
（Ｐ）］ olfactory receptor 4 [Gallus gallus] (X94744)；171
/301 (56%) 配列番号４４４［ＴＭ１；３−２５（Ｓ）、ＴＭ２；３
７−５９（Ｓ）、ＴＭ３；７８−１００（Ｐ）、ＴＭ
４；１４７−１６９（Ｐ）、ＴＭ５；１８４−２０６
（Ｐ）、ＴＭ６；２１４−２３５（Ｓ）］ olfactory receptor OR93Ch [Pan troglodytes] (AF045
577)；134/245 (54%) 配列番号４４６［ＴＭ１；８−３０（Ｐ）、ＴＭ２；３
３−５４（Ｐ）、ＴＭ３；９５−１１７（Ｓ）、ＴＭ
４；１２６−１４８（Ｐ）、ＴＭ５；２０８−２３０
（Ｐ）、ＴＭ６；２７１−２９３（Ｓ）］ ol factory receptor 4 [Gallus gallus] (X94744)；14
9/304 (49%) 配列番号４４８［ＴＭ１；５７−７９（Ｐ）、ＴＭ２；
９６−１１８（Ｓ）、ＴＭ３；１３１−１５３（Ｓ）、
ＴＭ４；２０５−２２７（Ｓ）、ＴＭ５；２３７−２５
９（Ｐ）、ＴＭ６；２７４−２９５（Ｓ）］ taste bud receptor protein TB 641 [Rattus norvegic
us] (U50949)；173/298(58%) 配列番号４５０［ＴＭ１；１９−４１（Ｐ）、ＴＭ２；
６２−８４（Ｐ）、ＴＭ３；９５−１１７（Ｐ）、ＴＭ
４；１４１−１６３（Ｐ）、ＴＭ５；２０２−２２４
（Ｐ）、ＴＭ６；２４０−２６１（Ｐ）、ＴＭ７；２７
２−２９４（Ｓ）］ olfactory receptor C6 [Mus musculus] (AF102523)；1
52/300 (50%)
（Ｓ）、ＴＭ２；７６−９８（Ｓ）、ＴＭ３；１３４−
１５６（Ｓ）、ＴＭ４；１９９−２２１（Ｐ）、ＴＭ
５；２４０−２６１（Ｓ）、ＴＭ６；２７０−２９１
（Ｐ）］ olfactory receptor 4 [Gallus gallus] (X94744)；171
/301 (56%) 配列番号４４４［ＴＭ１；３−２５（Ｓ）、ＴＭ２；３
７−５９（Ｓ）、ＴＭ３；７８−１００（Ｐ）、ＴＭ
４；１４７−１６９（Ｐ）、ＴＭ５；１８４−２０６
（Ｐ）、ＴＭ６；２１４−２３５（Ｓ）］ olfactory receptor OR93Ch [Pan troglodytes] (AF045
577)；134/245 (54%) 配列番号４４６［ＴＭ１；８−３０（Ｐ）、ＴＭ２；３
３−５４（Ｐ）、ＴＭ３；９５−１１７（Ｓ）、ＴＭ
４；１２６−１４８（Ｐ）、ＴＭ５；２０８−２３０
（Ｐ）、ＴＭ６；２７１−２９３（Ｓ）］ ol factory receptor 4 [Gallus gallus] (X94744)；14
9/304 (49%) 配列番号４４８［ＴＭ１；５７−７９（Ｐ）、ＴＭ２；
９６−１１８（Ｓ）、ＴＭ３；１３１−１５３（Ｓ）、
ＴＭ４；２０５−２２７（Ｓ）、ＴＭ５；２３７−２５
９（Ｐ）、ＴＭ６；２７４−２９５（Ｓ）］ taste bud receptor protein TB 641 [Rattus norvegic
us] (U50949)；173/298(58%) 配列番号４５０［ＴＭ１；１９−４１（Ｐ）、ＴＭ２；
６２−８４（Ｐ）、ＴＭ３；９５−１１７（Ｐ）、ＴＭ
４；１４１−１６３（Ｐ）、ＴＭ５；２０２−２２４
（Ｐ）、ＴＭ６；２４０−２６１（Ｐ）、ＴＭ７；２７
２−２９４（Ｓ）］ olfactory receptor C6 [Mus musculus] (AF102523)；1
52/300 (50%)
【００８７】配列番号４５２［ＴＭ１；３１−５３
（Ｐ）、ＴＭ２；９５−１１７（Ｐ）、ＴＭ３；１２５
−１４７（Ｐ）、ＴＭ４；１８０−２０２（Ｓ）、ＴＭ
５；２０８−２２９（Ｐ）、ＴＭ６；２３８−２６０
（Ｓ）、ＴＭ７；２７２−２９４（Ｐ）］ olfactory receptor [Rattus norvegicus] (X80671)；1
93/301 (64%) 配列番号４５４［ＴＭ１；２−２４（Ｓ）、ＴＭ２；２
９−５１（Ｓ）、ＴＭ３；５９−８１（Ｓ）、ＴＭ４；
１０７−１２９（Ｓ）、ＴＭ５；１６９−１９０
（Ｐ）、ＴＭ６；２０１−２２３（Ｐ）］ odorant receptor MOR83 [Mus musculus] (AB030894)；
156/269 (57%) 配列番号４５６［ＴＭ１；１−２１（Ｓ）、ＴＭ２；４
０−６２（Ｐ）、ＴＭ３；９８−１２０（Ｐ）、ＴＭ
４；２２３−２４５（Ｐ）、ＴＭ５；２５９−２８１
（Ｓ）、ＴＭ６；２９８−３２０（Ｐ）］ taste bud receptor protein TB 641 [Rattus norvegic
us] (U50949)；154/249(61%) 配列番号４５８［ＴＭ１；２５−４７（Ｐ）、ＴＭ２；
５５−７７（Ｓ）、ＴＭ３；９７−１１９（Ｓ）、ＴＭ
４；１４０−１６２（Ｓ）、ＴＭ５；２００−２２２
（Ｐ）、ＴＭ６；２３６−２５８（Ｓ）］ olfactory receptor 4 [Gallus gallus] (X94744)；153
/303 (50%) 配列番号４６０［ＴＭ１；１−１７（Ｓ）、ＴＭ２；２
７−４９（Ｓ）、ＴＭ３；６７−８９（Ｐ）、ＴＭ４；
１０２−１２４（Ｐ）、ＴＭ５；１７４−１９６
（Ｓ）、ＴＭ６；２０８−２３０（Ｐ）、ＴＭ７；２３
８−２６０（Ｓ）］ olfactory receptor [Homo sapiens] (Y10529)；185/26
1 (70%)
（Ｐ）、ＴＭ２；９５−１１７（Ｐ）、ＴＭ３；１２５
−１４７（Ｐ）、ＴＭ４；１８０−２０２（Ｓ）、ＴＭ
５；２０８−２２９（Ｐ）、ＴＭ６；２３８−２６０
（Ｓ）、ＴＭ７；２７２−２９４（Ｐ）］ olfactory receptor [Rattus norvegicus] (X80671)；1
93/301 (64%) 配列番号４５４［ＴＭ１；２−２４（Ｓ）、ＴＭ２；２
９−５１（Ｓ）、ＴＭ３；５９−８１（Ｓ）、ＴＭ４；
１０７−１２９（Ｓ）、ＴＭ５；１６９−１９０
（Ｐ）、ＴＭ６；２０１−２２３（Ｐ）］ odorant receptor MOR83 [Mus musculus] (AB030894)；
156/269 (57%) 配列番号４５６［ＴＭ１；１−２１（Ｓ）、ＴＭ２；４
０−６２（Ｐ）、ＴＭ３；９８−１２０（Ｐ）、ＴＭ
４；２２３−２４５（Ｐ）、ＴＭ５；２５９−２８１
（Ｓ）、ＴＭ６；２９８−３２０（Ｐ）］ taste bud receptor protein TB 641 [Rattus norvegic
us] (U50949)；154/249(61%) 配列番号４５８［ＴＭ１；２５−４７（Ｐ）、ＴＭ２；
５５−７７（Ｓ）、ＴＭ３；９７−１１９（Ｓ）、ＴＭ
４；１４０−１６２（Ｓ）、ＴＭ５；２００−２２２
（Ｐ）、ＴＭ６；２３６−２５８（Ｓ）］ olfactory receptor 4 [Gallus gallus] (X94744)；153
/303 (50%) 配列番号４６０［ＴＭ１；１−１７（Ｓ）、ＴＭ２；２
７−４９（Ｓ）、ＴＭ３；６７−８９（Ｐ）、ＴＭ４；
１０２−１２４（Ｐ）、ＴＭ５；１７４−１９６
（Ｓ）、ＴＭ６；２０８−２３０（Ｐ）、ＴＭ７；２３
８−２６０（Ｓ）］ olfactory receptor [Homo sapiens] (Y10529)；185/26
1 (70%)
【００８８】配列番号４６２［ＴＭ１；１−２０
（Ｓ）、ＴＭ２；５７−７９（Ｐ）、ＴＭ３；８９−１
１１（Ｓ）、ＴＭ４；１２２−１４４（Ｐ）、ＴＭ５；
１５６−１７８（Ｐ）、ＴＭ６；２２４−２４６
（Ｐ）］ olfactory receptor 4 [Gallus gallus] (X94744)；122
/229 (53%) 配列番号４６４［ＴＭ１；３２−５４（Ｓ）、ＴＭ２；
９２−１１４（Ｐ）、ＴＭ３；１４０−１６２（Ｓ）、
ＴＭ４；１９７−２１９（Ｓ）、ＴＭ５；２３８−２６
０（Ｓ）、ＴＭ６；２７２−２９３（Ｐ）］ olfactory receptor OR93Gib [Hylobates lar] (AF0455
80)；160/309 (51%) 配列番号４６６［ＴＭ１；１−２３（Ｓ）、ＴＭ２；３
３−５５（Ｓ）、ＴＭ３；６９−９１（Ｐ）、ＴＭ４；
１５０−１７１（Ｐ）、ＴＭ５；１８２−２０４
（Ｐ）、ＴＭ６；２１１−２３３（Ｓ）］ HsOLF1 [Homo sapiens] (U56420)；147/247 (59%) 配列番号４６８［ＴＭ１；２６−４８（Ｐ）、ＴＭ２；
９４−１１６（Ｐ）、ＴＭ３；１３６−１５８（Ｐ）、
ＴＭ４；１８０−２０２（Ｓ）、ＴＭ５；２０９−２３
１（Ｐ）、ＴＭ６；２３８−２６０（Ｓ）、ＴＭ７；２
７１−２９２（Ｐ）］ olfactory receptor 4 [Gallus gallus] (X94744)；170
/307 (55%) 配列番号４７０［ＴＭ１；７−２９（Ｐ）、ＴＭ２；３
５−５７（Ｓ）、ＴＭ３；７０−９２（Ｓ）、ＴＭ４；
１８４−２０５（Ｐ）、ＴＭ５；２１３−２３５
（Ｓ）、ＴＭ６；２４７−２６８（Ｐ））］ olfactory receptor OR93Gib [Hylobates lar] (AF0455
80)；151/283 (53%)
（Ｓ）、ＴＭ２；５７−７９（Ｐ）、ＴＭ３；８９−１
１１（Ｓ）、ＴＭ４；１２２−１４４（Ｐ）、ＴＭ５；
１５６−１７８（Ｐ）、ＴＭ６；２２４−２４６
（Ｐ）］ olfactory receptor 4 [Gallus gallus] (X94744)；122
/229 (53%) 配列番号４６４［ＴＭ１；３２−５４（Ｓ）、ＴＭ２；
９２−１１４（Ｐ）、ＴＭ３；１４０−１６２（Ｓ）、
ＴＭ４；１９７−２１９（Ｓ）、ＴＭ５；２３８−２６
０（Ｓ）、ＴＭ６；２７２−２９３（Ｐ）］ olfactory receptor OR93Gib [Hylobates lar] (AF0455
80)；160/309 (51%) 配列番号４６６［ＴＭ１；１−２３（Ｓ）、ＴＭ２；３
３−５５（Ｓ）、ＴＭ３；６９−９１（Ｐ）、ＴＭ４；
１５０−１７１（Ｐ）、ＴＭ５；１８２−２０４
（Ｐ）、ＴＭ６；２１１−２３３（Ｓ）］ HsOLF1 [Homo sapiens] (U56420)；147/247 (59%) 配列番号４６８［ＴＭ１；２６−４８（Ｐ）、ＴＭ２；
９４−１１６（Ｐ）、ＴＭ３；１３６−１５８（Ｐ）、
ＴＭ４；１８０−２０２（Ｓ）、ＴＭ５；２０９−２３
１（Ｐ）、ＴＭ６；２３８−２６０（Ｓ）、ＴＭ７；２
７１−２９２（Ｐ）］ olfactory receptor 4 [Gallus gallus] (X94744)；170
/307 (55%) 配列番号４７０［ＴＭ１；７−２９（Ｐ）、ＴＭ２；３
５−５７（Ｓ）、ＴＭ３；７０−９２（Ｓ）、ＴＭ４；
１８４−２０５（Ｐ）、ＴＭ５；２１３−２３５
（Ｓ）、ＴＭ６；２４７−２６８（Ｐ））］ olfactory receptor OR93Gib [Hylobates lar] (AF0455
80)；151/283 (53%)
【００８９】配列番号４７２［ＴＭ１；１９−４１
（Ｐ）、ＴＭ２；５６−７８（Ｓ）、ＴＭ３；１０４−
１２６（Ｐ）、ＴＭ４；１４４−１６６（Ｐ）、ＴＭ
５；２０３−２２４（Ｐ）、ＴＭ６；２３７−２５９
（Ｐ）、ＴＭ７；２６９−２９１（Ｐ）］ odorant receptor MOR83 [Mus musculus] (AB030894)；
160/306 (52%) 配列番号４７４［ＴＭ１；２７−４９（Ｐ）、ＴＭ２；
１４２−１６４（Ｓ）、ＴＭ３；１７２−１９３
（Ｓ）、ＴＭ４；２０５−２２６（Ｐ）、ＴＭ５；２４
２−２６４（Ｐ）、ＴＭ６；２６８−２９０（Ｓ）］ odorant receptor MOR83 [Mus musculus] (AB030894)；
170/308 (55%) 配列番号４７６［ＴＭ１；３７−５９（Ｐ）、ＴＭ２；
１０８−１３０（Ｓ）、ＴＭ３；１５３−１７５
（Ｐ）、ＴＭ４；１８８−２１０（Ｐ）、ＴＭ５；２１
４−２３５（Ｐ）、ＴＭ６；２５１−２７３（Ｐ）、Ｔ
Ｍ７；２７８−３００（Ｓ）］ odorant receptor MOR83 [Mus musculus] (AB030894)；
168/297 (56%) 配列番号４７８［ＴＭ１；２９−５１（Ｐ）、ＴＭ２；
５８−８０（Ｓ）、ＴＭ３；１４１−１６３（Ｐ）、Ｔ
Ｍ４；１７７−１９９（Ｐ）、ＴＭ５；２０５−２２６
（Ｐ）、ＴＭ６；２３９−２６１（Ｐ）、ＴＭ７；２７
１−２９３（Ｓ）］ odorant receptor MOR83 [Mus musculus] (AB030894)；
159/300 (53%) 配列番号４８０［ＴＭ１；３０−５２（Ｐ）、ＴＭ２；
９５−１１７（Ｓ）、ＴＭ３；１４９−１７１（Ｓ）、
ＴＭ４；１９７−２１９（Ｐ）、ＴＭ５；２４１−２６
３（Ｐ）、ＴＭ６；２６８−２９０（Ｐ）］ similar to rat olfactory receptor OR18; similar to
S29710 (PID:g423702)[Homo sapiens] (AC004908)；16
7/312 (53%)
（Ｐ）、ＴＭ２；５６−７８（Ｓ）、ＴＭ３；１０４−
１２６（Ｐ）、ＴＭ４；１４４−１６６（Ｐ）、ＴＭ
５；２０３−２２４（Ｐ）、ＴＭ６；２３７−２５９
（Ｐ）、ＴＭ７；２６９−２９１（Ｐ）］ odorant receptor MOR83 [Mus musculus] (AB030894)；
160/306 (52%) 配列番号４７４［ＴＭ１；２７−４９（Ｐ）、ＴＭ２；
１４２−１６４（Ｓ）、ＴＭ３；１７２−１９３
（Ｓ）、ＴＭ４；２０５−２２６（Ｐ）、ＴＭ５；２４
２−２６４（Ｐ）、ＴＭ６；２６８−２９０（Ｓ）］ odorant receptor MOR83 [Mus musculus] (AB030894)；
170/308 (55%) 配列番号４７６［ＴＭ１；３７−５９（Ｐ）、ＴＭ２；
１０８−１３０（Ｓ）、ＴＭ３；１５３−１７５
（Ｐ）、ＴＭ４；１８８−２１０（Ｐ）、ＴＭ５；２１
４−２３５（Ｐ）、ＴＭ６；２５１−２７３（Ｐ）、Ｔ
Ｍ７；２７８−３００（Ｓ）］ odorant receptor MOR83 [Mus musculus] (AB030894)；
168/297 (56%) 配列番号４７８［ＴＭ１；２９−５１（Ｐ）、ＴＭ２；
５８−８０（Ｓ）、ＴＭ３；１４１−１６３（Ｐ）、Ｔ
Ｍ４；１７７−１９９（Ｐ）、ＴＭ５；２０５−２２６
（Ｐ）、ＴＭ６；２３９−２６１（Ｐ）、ＴＭ７；２７
１−２９３（Ｓ）］ odorant receptor MOR83 [Mus musculus] (AB030894)；
159/300 (53%) 配列番号４８０［ＴＭ１；３０−５２（Ｐ）、ＴＭ２；
９５−１１７（Ｓ）、ＴＭ３；１４９−１７１（Ｓ）、
ＴＭ４；１９７−２１９（Ｐ）、ＴＭ５；２４１−２６
３（Ｐ）、ＴＭ６；２６８−２９０（Ｐ）］ similar to rat olfactory receptor OR18; similar to
S29710 (PID:g423702)[Homo sapiens] (AC004908)；16
7/312 (53%)
【００９０】配列番号４８２［ＴＭ１；２３−４５
（Ｐ）、ＴＭ２；５８−８０（Ｓ）、ＴＭ３；９６−１
１８（Ｓ）、ＴＭ４；１４１−１６３（Ｓ）、ＴＭ５；
２００−２２２（Ｐ）、ＴＭ６；２４５−２６７
（Ｓ）、ＴＭ７；２７０−２９２（Ｓ）］ CfOLF1 [Canis familiaris] (U53679)；149/310 (48%) 配列番号４８４［ＴＭ１；２９−５０（Ｐ）、ＴＭ２；
６０−８２（Ｓ）、ＴＭ３；９５−１１７（Ｐ）、ＴＭ
４；１３４−１５６（Ｓ）、ＴＭ５；２０３−２２５
（Ｐ）、ＴＭ６；２３８−２５９（Ｓ）、ＴＭ７；２７
４−２９４（Ｓ）］ olfactory receptor P2 [Mus musculus] (AF247657)；1
44/307 (46%) 配列番号４８６［ＴＭ１；２６−４８（Ｓ）、ＴＭ２；
８８−１１０（Ｐ）、ＴＭ３；１３６−１５８（Ｓ）、
ＴＭ４；１９４−２１６（Ｐ）、ＴＭ５；２３１−２５
３（Ｐ）、ＴＭ６；２５９−２８１（Ｓ）］ similar to rat olfactory receptor OR18; similar to
S29710 (PID:g423702)[Homo sapiens] (AC004908)；17
7/296 (59%) 配列番号４８８［ＴＭ１；３０−５２（Ｐ）、ＴＭ２；
７０−９２（Ｓ）、ＴＭ３；１０６−１２８（Ｓ）、Ｔ
Ｍ４；１４６−１６８（Ｐ）、ＴＭ５；１９６−２１８
（Ｐ）、ＴＭ６；２３９−２６１（Ｓ）、ＴＭ７；２７
０−２９２（Ｓ）］ odorant receptor S46 [Mus musculus] (AF121979)；18
8/304 (61%) 配列番号４９０［ＴＭ１；２５−４７（Ｐ）、ＴＭ２；
５３−７５（Ｓ）、ＴＭ３；１５０−１７２（Ｓ）、Ｔ
Ｍ４；１９９−２２１（Ｐ）、ＴＭ５；２３５−２５７
（Ｐ）、ＴＭ６；２６９−２９１（Ｓ）］ odorant receptor MOR18 [Mus musculus] (AB030895)；
193/301 (64%)
（Ｐ）、ＴＭ２；５８−８０（Ｓ）、ＴＭ３；９６−１
１８（Ｓ）、ＴＭ４；１４１−１６３（Ｓ）、ＴＭ５；
２００−２２２（Ｐ）、ＴＭ６；２４５−２６７
（Ｓ）、ＴＭ７；２７０−２９２（Ｓ）］ CfOLF1 [Canis familiaris] (U53679)；149/310 (48%) 配列番号４８４［ＴＭ１；２９−５０（Ｐ）、ＴＭ２；
６０−８２（Ｓ）、ＴＭ３；９５−１１７（Ｐ）、ＴＭ
４；１３４−１５６（Ｓ）、ＴＭ５；２０３−２２５
（Ｐ）、ＴＭ６；２３８−２５９（Ｓ）、ＴＭ７；２７
４−２９４（Ｓ）］ olfactory receptor P2 [Mus musculus] (AF247657)；1
44/307 (46%) 配列番号４８６［ＴＭ１；２６−４８（Ｓ）、ＴＭ２；
８８−１１０（Ｐ）、ＴＭ３；１３６−１５８（Ｓ）、
ＴＭ４；１９４−２１６（Ｐ）、ＴＭ５；２３１−２５
３（Ｐ）、ＴＭ６；２５９−２８１（Ｓ）］ similar to rat olfactory receptor OR18; similar to
S29710 (PID:g423702)[Homo sapiens] (AC004908)；17
7/296 (59%) 配列番号４８８［ＴＭ１；３０−５２（Ｐ）、ＴＭ２；
７０−９２（Ｓ）、ＴＭ３；１０６−１２８（Ｓ）、Ｔ
Ｍ４；１４６−１６８（Ｐ）、ＴＭ５；１９６−２１８
（Ｐ）、ＴＭ６；２３９−２６１（Ｓ）、ＴＭ７；２７
０−２９２（Ｓ）］ odorant receptor S46 [Mus musculus] (AF121979)；18
8/304 (61%) 配列番号４９０［ＴＭ１；２５−４７（Ｐ）、ＴＭ２；
５３−７５（Ｓ）、ＴＭ３；１５０−１７２（Ｓ）、Ｔ
Ｍ４；１９９−２２１（Ｐ）、ＴＭ５；２３５−２５７
（Ｐ）、ＴＭ６；２６９−２９１（Ｓ）］ odorant receptor MOR18 [Mus musculus] (AB030895)；
193/301 (64%)
【００９１】配列番号４９２［ＴＭ１；６−２８
（Ｓ）、ＴＭ２；３０−５１（Ｓ）、ＴＭ３；１０５−
１２７（Ｐ）、ＴＭ４；１３８−１６０（Ｐ）、ＴＭ
５；１６９−１９１（Ｓ）、ＴＭ６；１９９−２２１
（Ｐ）、ＴＭ７；２３５−２５７（Ｐ）、ＴＭ８；２６
６−２８８（Ｓ）］ odorant receptor A16 [Mus musculus] (AB030896)；18
4/302 (60%) 配列番号４９４［ＴＭ１；２４−４６（Ｐ）、ＴＭ２；
５７−７９（Ｓ）、ＴＭ３；１０８−１３０（Ｓ）、Ｔ
Ｍ４；１４５−１６７（Ｓ）、ＴＭ５；１７７−１９９
（Ｓ）、ＴＭ６；２０９−２３１（Ｐ）、ＴＭ７；２３
９−２６１（Ｓ）、ＴＭ８；２７０−２９２（Ｐ）］ odorant receptor S1 [Mus musculus] (AF121972)；129
/297 (43%) 配列番号４９６［ＴＭ１；７４−９６（Ｐ）、ＴＭ２；
１２６−１４８（Ｓ）、ＴＭ３；１６９−１９１
（Ｐ）、ＴＭ４；２０６−２２８（Ｐ）、ＴＭ５；２３
４−２５５（Ｐ）、ＴＭ６；２６６−２８８（Ｐ）、Ｔ
Ｍ７；２９７−３１９（Ｐ）］ olfactory receptor P2 [Mus musculus] (AF247657)；1
30/305 (42%) 配列番号４９８［ＴＭ１；４８−７０（Ｐ）、ＴＭ２；
７３−９５（Ｓ）、ＴＭ３；９９−１２１（Ｓ）、ＴＭ
４；１３０−１５１（Ｓ）、ＴＭ５；１６２−１８４
（Ｐ）、ＴＭ６；２２２−２４４（Ｐ）、ＴＭ７；２５
４−２７５（Ｐ）、ＴＭ８；２８４−３０６（Ｓ）］ chick olfactory receptor 7 [Gallus gallus] (Z7958
6)；130/303 (42%) 配列番号５００［ＴＭ１；８−３０（Ｐ）、ＴＭ２；３
４−５６（Ｐ）、ＴＭ３；８２−１０４（Ｓ）、ＴＭ
４；１４０−１６２（Ｐ）、ＴＭ５；２０２−２２４
（Ｐ）、ＴＭ６；２４０−２６１（Ｐ）、ＴＭ７；２６
９−２９１（Ｓ）］ odorant receptor S1 [Mus musculus] (AF121972)；143
/307 (46%)
（Ｓ）、ＴＭ２；３０−５１（Ｓ）、ＴＭ３；１０５−
１２７（Ｐ）、ＴＭ４；１３８−１６０（Ｐ）、ＴＭ
５；１６９−１９１（Ｓ）、ＴＭ６；１９９−２２１
（Ｐ）、ＴＭ７；２３５−２５７（Ｐ）、ＴＭ８；２６
６−２８８（Ｓ）］ odorant receptor A16 [Mus musculus] (AB030896)；18
4/302 (60%) 配列番号４９４［ＴＭ１；２４−４６（Ｐ）、ＴＭ２；
５７−７９（Ｓ）、ＴＭ３；１０８−１３０（Ｓ）、Ｔ
Ｍ４；１４５−１６７（Ｓ）、ＴＭ５；１７７−１９９
（Ｓ）、ＴＭ６；２０９−２３１（Ｐ）、ＴＭ７；２３
９−２６１（Ｓ）、ＴＭ８；２７０−２９２（Ｐ）］ odorant receptor S1 [Mus musculus] (AF121972)；129
/297 (43%) 配列番号４９６［ＴＭ１；７４−９６（Ｐ）、ＴＭ２；
１２６−１４８（Ｓ）、ＴＭ３；１６９−１９１
（Ｐ）、ＴＭ４；２０６−２２８（Ｐ）、ＴＭ５；２３
４−２５５（Ｐ）、ＴＭ６；２６６−２８８（Ｐ）、Ｔ
Ｍ７；２９７−３１９（Ｐ）］ olfactory receptor P2 [Mus musculus] (AF247657)；1
30/305 (42%) 配列番号４９８［ＴＭ１；４８−７０（Ｐ）、ＴＭ２；
７３−９５（Ｓ）、ＴＭ３；９９−１２１（Ｓ）、ＴＭ
４；１３０−１５１（Ｓ）、ＴＭ５；１６２−１８４
（Ｐ）、ＴＭ６；２２２−２４４（Ｐ）、ＴＭ７；２５
４−２７５（Ｐ）、ＴＭ８；２８４−３０６（Ｓ）］ chick olfactory receptor 7 [Gallus gallus] (Z7958
6)；130/303 (42%) 配列番号５００［ＴＭ１；８−３０（Ｐ）、ＴＭ２；３
４−５６（Ｐ）、ＴＭ３；８２−１０４（Ｓ）、ＴＭ
４；１４０−１６２（Ｐ）、ＴＭ５；２０２−２２４
（Ｐ）、ＴＭ６；２４０−２６１（Ｐ）、ＴＭ７；２６
９−２９１（Ｓ）］ odorant receptor S1 [Mus musculus] (AF121972)；143
/307 (46%)
【００９２】配列番号５０２［ＴＭ１；１−２３
（Ｓ）、ＴＭ２；４２−６４（Ｓ）、ＴＭ３；８４−１
０６（Ｐ）、ＴＭ４；１４８−１６９（Ｐ）、ＴＭ５；
１８４−２０５（Ｓ）、ＴＭ６；２１３−２３５
（Ｓ）］ olfactory receptor E6 [Mus musculus] (AF102528)；1
55/223 (69%) 配列番号５０４［ＴＭ１；２−２４（Ｓ）、ＴＭ２；４
０−６２（Ｓ）、ＴＭ３；８０−１０２（Ｐ）、ＴＭ
４；１４４−１６６（Ｐ）、ＴＭ５；１８１−２０２
（Ｓ）、ＴＭ６；２１４−２３５（Ｓ）］ olfactory receptor [Rattus norvegicus] (X80671)；1
27/243 (52%) 配列番号５０６［ＴＭ１；１−２３（Ｐ）、ＴＭ２；２
７−４９（Ｐ）、ＴＭ３；６５−８７（Ｓ）、ＴＭ４；
８９−１１１（Ｐ）、ＴＭ５；１５６−１７８（Ｐ）、
ＴＭ６；１９４−２１５（Ｐ）、ＴＭ７；２２７−２４
９（Ｓ）］ olfactory receptor [Gorilla gorilla] (AF101764)；9
3/214 (43%) 配列番号５０８［ＴＭ１；１１−３３（Ｐ）、ＴＭ２；
４９−７１（Ｓ）、ＴＭ３；８０−１０２（Ｓ）、ＴＭ
４；１２８−１５０（Ｓ）、ＴＭ５；１９３−２１５
（Ｐ）、ＴＭ６；２２５−２４７（Ｐ）、ＴＭ７；２５
４−２７６（Ｓ）］ olfactory receptor P2 [Mus musculus] (AF247657)；1
28/290 (44%) 配列番号５１０［ＴＭ１；１８−４０（Ｐ）、ＴＭ２；
５６−７８（Ｐ）、ＴＭ３；９１−１１３（Ｓ）、ＴＭ
４；１２５−１４７（Ｓ）、ＴＭ５；２００−２２２
（Ｐ）、ＴＭ６；２４２−２６４（Ｓ）、ＴＭ７；２６
９−２９１（Ｓ）］ olfactory receptor-like protein [Rattus norvegicu
s] (AF029357)；129/300(43%)
（Ｓ）、ＴＭ２；４２−６４（Ｓ）、ＴＭ３；８４−１
０６（Ｐ）、ＴＭ４；１４８−１６９（Ｐ）、ＴＭ５；
１８４−２０５（Ｓ）、ＴＭ６；２１３−２３５
（Ｓ）］ olfactory receptor E6 [Mus musculus] (AF102528)；1
55/223 (69%) 配列番号５０４［ＴＭ１；２−２４（Ｓ）、ＴＭ２；４
０−６２（Ｓ）、ＴＭ３；８０−１０２（Ｐ）、ＴＭ
４；１４４−１６６（Ｐ）、ＴＭ５；１８１−２０２
（Ｓ）、ＴＭ６；２１４−２３５（Ｓ）］ olfactory receptor [Rattus norvegicus] (X80671)；1
27/243 (52%) 配列番号５０６［ＴＭ１；１−２３（Ｐ）、ＴＭ２；２
７−４９（Ｐ）、ＴＭ３；６５−８７（Ｓ）、ＴＭ４；
８９−１１１（Ｐ）、ＴＭ５；１５６−１７８（Ｐ）、
ＴＭ６；１９４−２１５（Ｐ）、ＴＭ７；２２７−２４
９（Ｓ）］ olfactory receptor [Gorilla gorilla] (AF101764)；9
3/214 (43%) 配列番号５０８［ＴＭ１；１１−３３（Ｐ）、ＴＭ２；
４９−７１（Ｓ）、ＴＭ３；８０−１０２（Ｓ）、ＴＭ
４；１２８−１５０（Ｓ）、ＴＭ５；１９３−２１５
（Ｐ）、ＴＭ６；２２５−２４７（Ｐ）、ＴＭ７；２５
４−２７６（Ｓ）］ olfactory receptor P2 [Mus musculus] (AF247657)；1
28/290 (44%) 配列番号５１０［ＴＭ１；１８−４０（Ｐ）、ＴＭ２；
５６−７８（Ｐ）、ＴＭ３；９１−１１３（Ｓ）、ＴＭ
４；１２５−１４７（Ｓ）、ＴＭ５；２００−２２２
（Ｐ）、ＴＭ６；２４２−２６４（Ｓ）、ＴＭ７；２６
９−２９１（Ｓ）］ olfactory receptor-like protein [Rattus norvegicu
s] (AF029357)；129/300(43%)
【００９３】配列番号５１２［ＴＭ１；２５−４７
（Ｐ）、ＴＭ２；５５−７７（Ｓ）、ＴＭ３；９３−１
１５（Ｐ）、ＴＭ４；１２４−１４６（Ｓ）、ＴＭ５；
２０６−２２８（Ｐ）、ＴＭ６；２３７−２５９
（Ｐ）、ＴＭ７；２７０−２９１（Ｓ）］ olfactory receptor [Gorilla gorilla] (AF101764)；1
25/302 (41%) 配列番号５１４［ＴＭ１；８−３０（Ｓ）、ＴＭ２；３
２−５１（Ｐ）、ＴＭ３；６３−８５（Ｓ）、ＴＭ４；
９４−１１６（Ｓ）、ＴＭ５；１４１−１６３（Ｐ）、
ＴＭ６；２０１−２２３（Ｐ）、ＴＭ７；２４４−２６
６（Ｓ）、ＴＭ８；２７２−２９３（Ｓ）］ olfactory receptor-like protein [Rattus norvegicu
s] (AF029357)；131/297(44%) 配列番号５１６［ＴＭ１；２６−４８（Ｐ）、ＴＭ２；
５３−７５（Ｓ）、ＴＭ３；９６−１１８（Ｓ）、ＴＭ
４；１３５−１５７（Ｐ）、ＴＭ５；１９８−２２０
（Ｐ）、ＴＭ６；２４１−２６３（Ｓ）、ＴＭ７；２７
０−２９１（Ｓ）］ gustatory receptor 43 [Rattus norvegicus] (AB03816
7)；265/311 (85%) 配列番号５１８［ＴＭ１；３１−５２（Ｐ）、ＴＭ２；
６２−８４（Ｓ）、ＴＭ３；９９−１２１（Ｐ）、ＴＭ
４；１４４−１６６（Ｓ）、ＴＭ５；２０２−２２４
（Ｐ）、ＴＭ６；２３６−２５８（Ｐ）、ＴＭ７；２７
１−２９２（Ｓ）］ dJ80I19.7 (olfactory receptor-like protein (hs6M1-
3)) [Homo sapiens] (AL022727)；174/304 (57%) 配列番号５２０［ＴＭ１；８−３０（Ｐ）、ＴＭ２；７
９−１０１（Ｐ）、ＴＭ３；１２８−１５０（Ｓ）、Ｔ
Ｍ４；１８６−２０８（Ｐ）、ＴＭ５；２２６−２４７
（Ｓ）、ＴＭ６；２５７−２７７（Ｓ）］ gustatory receptor 43 [Rattus norvegicus] (AB03816
7)；169/283 (59%)
（Ｐ）、ＴＭ２；５５−７７（Ｓ）、ＴＭ３；９３−１
１５（Ｐ）、ＴＭ４；１２４−１４６（Ｓ）、ＴＭ５；
２０６−２２８（Ｐ）、ＴＭ６；２３７−２５９
（Ｐ）、ＴＭ７；２７０−２９１（Ｓ）］ olfactory receptor [Gorilla gorilla] (AF101764)；1
25/302 (41%) 配列番号５１４［ＴＭ１；８−３０（Ｓ）、ＴＭ２；３
２−５１（Ｐ）、ＴＭ３；６３−８５（Ｓ）、ＴＭ４；
９４−１１６（Ｓ）、ＴＭ５；１４１−１６３（Ｐ）、
ＴＭ６；２０１−２２３（Ｐ）、ＴＭ７；２４４−２６
６（Ｓ）、ＴＭ８；２７２−２９３（Ｓ）］ olfactory receptor-like protein [Rattus norvegicu
s] (AF029357)；131/297(44%) 配列番号５１６［ＴＭ１；２６−４８（Ｐ）、ＴＭ２；
５３−７５（Ｓ）、ＴＭ３；９６−１１８（Ｓ）、ＴＭ
４；１３５−１５７（Ｐ）、ＴＭ５；１９８−２２０
（Ｐ）、ＴＭ６；２４１−２６３（Ｓ）、ＴＭ７；２７
０−２９１（Ｓ）］ gustatory receptor 43 [Rattus norvegicus] (AB03816
7)；265/311 (85%) 配列番号５１８［ＴＭ１；３１−５２（Ｐ）、ＴＭ２；
６２−８４（Ｓ）、ＴＭ３；９９−１２１（Ｐ）、ＴＭ
４；１４４−１６６（Ｓ）、ＴＭ５；２０２−２２４
（Ｐ）、ＴＭ６；２３６−２５８（Ｐ）、ＴＭ７；２７
１−２９２（Ｓ）］ dJ80I19.7 (olfactory receptor-like protein (hs6M1-
3)) [Homo sapiens] (AL022727)；174/304 (57%) 配列番号５２０［ＴＭ１；８−３０（Ｐ）、ＴＭ２；７
９−１０１（Ｐ）、ＴＭ３；１２８−１５０（Ｓ）、Ｔ
Ｍ４；１８６−２０８（Ｐ）、ＴＭ５；２２６−２４７
（Ｓ）、ＴＭ６；２５７−２７７（Ｓ）］ gustatory receptor 43 [Rattus norvegicus] (AB03816
7)；169/283 (59%)
【００９４】配列番号５２２［ＴＭ１；３２−５４
（Ｐ）、ＴＭ２；５６−７８（Ｓ）、ＴＭ３；９１−１
１３（Ｓ）、ＴＭ４；１４２−１６４（Ｓ）、ＴＭ５；
２０５−２２７（Ｐ）、ＴＭ６；２３８−２６０
（Ｓ）、ＴＭ７；２７２−２９４（Ｓ）］ olfactory protein [Rattus norvegicus] (M64377)；16
1/303 (53%) 配列番号５２４［ＴＭ１；１−２２（Ｓ）、ＴＭ２；２
９−５１（Ｓ）、ＴＭ３；１０１−１２３（Ｐ）、ＴＭ
４；１７２−１９４（Ｐ）、ＴＭ５；２１３−２３５
（Ｓ）、ＴＭ６；２３９−２６１（Ｓ）］ olfactory protein [Rattus norvegicus] (M64392)；16
5/268 (61%) 配列番号５２６［ＴＭ１；２８−５０（Ｐ）、ＴＭ２；
６１−８３（Ｓ）、ＴＭ３；１０３−１２５（Ｐ）、Ｔ
Ｍ４；１４０−１６２（Ｐ）、ＴＭ５；２０２−２２４
（Ｐ）、ＴＭ６；２３７−２５９（Ｐ）］ olfactory protein [Rattus norvegicus] (M64377)；16
1/305 (52%) 配列番号５２８［ＴＭ１；２７−４９（Ｐ）、ＴＭ２；
６３−８５（Ｓ）、ＴＭ３；９１−１１３（Ｓ）、ＴＭ
４；１４１−１６３（Ｓ）、ＴＭ５；１７７−１９９
（Ｓ）、ＴＭ６；２０６−２２８（Ｐ）、ＴＭ７；２４
０−２６２（Ｓ）、ＴＭ８；２７０−２９２（Ｓ）］ olfactory receptor [Pan troglodytes] (AF101741)；1
95/307 (63%) 配列番号５３０［ＴＭ１；２−２４（Ｓ）、ＴＭ２；３
１−５３（Ｓ）、ＴＭ３；６５−８７（Ｓ）、ＴＭ４；
１０９−１３１（Ｓ）、ＴＭ５；１６９−１９１
（Ｐ）、ＴＭ６；２０９−２２６（Ｓ）］ olfactory receptor [Mus musculus] (AJ251154)；190/
285 (66%)
（Ｐ）、ＴＭ２；５６−７８（Ｓ）、ＴＭ３；９１−１
１３（Ｓ）、ＴＭ４；１４２−１６４（Ｓ）、ＴＭ５；
２０５−２２７（Ｐ）、ＴＭ６；２３８−２６０
（Ｓ）、ＴＭ７；２７２−２９４（Ｓ）］ olfactory protein [Rattus norvegicus] (M64377)；16
1/303 (53%) 配列番号５２４［ＴＭ１；１−２２（Ｓ）、ＴＭ２；２
９−５１（Ｓ）、ＴＭ３；１０１−１２３（Ｐ）、ＴＭ
４；１７２−１９４（Ｐ）、ＴＭ５；２１３−２３５
（Ｓ）、ＴＭ６；２３９−２６１（Ｓ）］ olfactory protein [Rattus norvegicus] (M64392)；16
5/268 (61%) 配列番号５２６［ＴＭ１；２８−５０（Ｐ）、ＴＭ２；
６１−８３（Ｓ）、ＴＭ３；１０３−１２５（Ｐ）、Ｔ
Ｍ４；１４０−１６２（Ｐ）、ＴＭ５；２０２−２２４
（Ｐ）、ＴＭ６；２３７−２５９（Ｐ）］ olfactory protein [Rattus norvegicus] (M64377)；16
1/305 (52%) 配列番号５２８［ＴＭ１；２７−４９（Ｐ）、ＴＭ２；
６３−８５（Ｓ）、ＴＭ３；９１−１１３（Ｓ）、ＴＭ
４；１４１−１６３（Ｓ）、ＴＭ５；１７７−１９９
（Ｓ）、ＴＭ６；２０６−２２８（Ｐ）、ＴＭ７；２４
０−２６２（Ｓ）、ＴＭ８；２７０−２９２（Ｓ）］ olfactory receptor [Pan troglodytes] (AF101741)；1
95/307 (63%) 配列番号５３０［ＴＭ１；２−２４（Ｓ）、ＴＭ２；３
１−５３（Ｓ）、ＴＭ３；６５−８７（Ｓ）、ＴＭ４；
１０９−１３１（Ｓ）、ＴＭ５；１６９−１９１
（Ｐ）、ＴＭ６；２０９−２２６（Ｓ）］ olfactory receptor [Mus musculus] (AJ251154)；190/
285 (66%)
【００９５】配列番号５３２［ＴＭ１；３３−５５
（Ｐ）、ＴＭ２；９８−１２０（Ｓ）、ＴＭ３；１３２
−１５４（Ｓ）、ＴＭ４；１７５−１９７（Ｓ）、ＴＭ
５；２０５−２２７（Ｐ）、ＴＭ６；２３７−２５８
（Ｐ）、ＴＭ７；２７８−２９９（Ｓ）］ olfactory factor OR37 - rat(S29711); 244/304 (80%) 配列番号５３４［ＴＭ１；２−２４（Ｓ）、ＴＭ２；３
１−５３（Ｓ）、ＴＭ３；６５−８７（Ｓ）、ＴＭ４；
１０９−１３１（Ｓ）、ＴＭ５；１７１−１９３
（Ｐ）、ＴＭ６；２０８−２２６（Ｐ）］ olfactory receptor [Mus musculus] (AJ251154)；197/
285 (69%) 配列番号５３６［ＴＭ１；１−２３（Ｓ）、ＴＭ２；５
７−７９（Ｐ）、ＴＭ３；１２８−１５０（Ｓ）、ＴＭ
４；１６９−１９１（Ｓ）、ＴＭ５；２０６−２２８
（Ｐ）、ＴＭ６；２３７−２５９（Ｐ）、ＴＭ７；２６
７−２８８（Ｐ）、ＴＭ８；３０５−３２７（Ｓ）］ olfactory factor OR37 - rat(S29711)；259/304 (85%) 配列番号５３８［ＴＭ１；８−３０（Ｐ）、ＴＭ２；５
６−７８（Ｓ）、ＴＭ３；８１−１０３（Ｓ）、ＴＭ
４；１０７−１２９（Ｓ）、ＴＭ５；１４８−１７０
（Ｐ）、ＴＭ６；１７７−１９９（Ｐ）、ＴＭ７；２０
３−２２５（Ｐ）］ olfactory receptor [Mus musculus] (AJ251154)；16 6
/283 (58%) 配列番号５４０［ＴＭ１；２４−４６（Ｐ）、ＴＭ２；
６２−８４（Ｓ）、ＴＭ３；１０１−１２３（Ｓ）、Ｔ
Ｍ４；１３７−１５９（Ｓ）、ＴＭ５；１７１−１９３
（Ｓ）、ＴＭ６；２０７−２２９（Ｐ）、ＴＭ７；２３
７−２５８（Ｐ）、ＴＭ８；２７４−２９６（Ｓ）］ olfactory receptor [Mus musculus] (AJ251154)；219/
319 (68%)
（Ｐ）、ＴＭ２；９８−１２０（Ｓ）、ＴＭ３；１３２
−１５４（Ｓ）、ＴＭ４；１７５−１９７（Ｓ）、ＴＭ
５；２０５−２２７（Ｐ）、ＴＭ６；２３７−２５８
（Ｐ）、ＴＭ７；２７８−２９９（Ｓ）］ olfactory factor OR37 - rat(S29711); 244/304 (80%) 配列番号５３４［ＴＭ１；２−２４（Ｓ）、ＴＭ２；３
１−５３（Ｓ）、ＴＭ３；６５−８７（Ｓ）、ＴＭ４；
１０９−１３１（Ｓ）、ＴＭ５；１７１−１９３
（Ｐ）、ＴＭ６；２０８−２２６（Ｐ）］ olfactory receptor [Mus musculus] (AJ251154)；197/
285 (69%) 配列番号５３６［ＴＭ１；１−２３（Ｓ）、ＴＭ２；５
７−７９（Ｐ）、ＴＭ３；１２８−１５０（Ｓ）、ＴＭ
４；１６９−１９１（Ｓ）、ＴＭ５；２０６−２２８
（Ｐ）、ＴＭ６；２３７−２５９（Ｐ）、ＴＭ７；２６
７−２８８（Ｐ）、ＴＭ８；３０５−３２７（Ｓ）］ olfactory factor OR37 - rat(S29711)；259/304 (85%) 配列番号５３８［ＴＭ１；８−３０（Ｐ）、ＴＭ２；５
６−７８（Ｓ）、ＴＭ３；８１−１０３（Ｓ）、ＴＭ
４；１０７−１２９（Ｓ）、ＴＭ５；１４８−１７０
（Ｐ）、ＴＭ６；１７７−１９９（Ｐ）、ＴＭ７；２０
３−２２５（Ｐ）］ olfactory receptor [Mus musculus] (AJ251154)；16 6
/283 (58%) 配列番号５４０［ＴＭ１；２４−４６（Ｐ）、ＴＭ２；
６２−８４（Ｓ）、ＴＭ３；１０１−１２３（Ｓ）、Ｔ
Ｍ４；１３７−１５９（Ｓ）、ＴＭ５；１７１−１９３
（Ｓ）、ＴＭ６；２０７−２２９（Ｐ）、ＴＭ７；２３
７−２５８（Ｐ）、ＴＭ８；２７４−２９６（Ｓ）］ olfactory receptor [Mus musculus] (AJ251154)；219/
319 (68%)
【００９６】配列番号５４２［ＴＭ１；４３−６５
（Ｐ）、ＴＭ２；１１７−１３９（Ｓ）、ＴＭ３；１５
２−１７４（Ｐ）、ＴＭ４；２１４−２３６（Ｐ）、Ｔ
Ｍ５；２５３−２７４（Ｓ）、ＴＭ６；２８６−３０６
（Ｓ）］ olfactory protein [Rattus norvegicus] (M64377)；17
4/311 (55%) 配列番号５４４［ＴＭ１；３９−６１（Ｐ）、ＴＭ２；
１１６−１３８（Ｐ）、ＴＭ３；１５２−１７４
（Ｐ）、ＴＭ４；２１４−２３６（Ｐ）、ＴＭ５；２５
３−２７４（Ｐ）、ＴＭ６；２８４−３０６（Ｓ）］ olfactory receptor [Homo sapiens] (AJ003147)；171/
308 (55%) 配列番号５４６［ＴＭ１；３３−５５（Ｐ）、ＴＭ２；
６８−９０（Ｐ）、ＴＭ３；１００−１２２（Ｓ）、Ｔ
Ｍ４；１４３−１６５（Ｓ）、ＴＭ５；２０８−２３０
（Ｐ）、ＴＭ６；２４４−２６６（Ｓ）、ＴＭ７；２７
９−２９８（Ｓ）］ HGMP07J [Homo sapiens] >gi|228481|prf||1804351C ol
factory receptor HGMP07J [Homo sapiens] (X64995)；
143/297 (48%) 配列番号５４８［ＴＭ１；１７−３９（Ｐ）、ＴＭ２；
７０−９２（Ｓ）、ＴＭ３；９８−１２０（Ｐ）、ＴＭ
４；１４５−１６７（Ｐ）、ＴＭ５；２０２−２２４
（Ｐ）、ＴＭ６；２３８−２５９（Ｓ）］ olfactory receptor OR93Gib [Hylobates lar] (AF0455
80)；149/309 (48%) 配列番号５５０［ＴＭ１；１−１９（Ｓ）、ＴＭ２；２
７−４９（Ｐ）、ＴＭ３；１０３−１２５（Ｓ）、ＴＭ
４；１３９−１６１（Ｐ）、ＴＭ５；２０１−２２３
（Ｐ）、ＴＭ６；２３７−２５８（Ｓ）］ olfactory factor OR37 - rat(S29711)；148/305 (48%)
（Ｐ）、ＴＭ２；１１７−１３９（Ｓ）、ＴＭ３；１５
２−１７４（Ｐ）、ＴＭ４；２１４−２３６（Ｐ）、Ｔ
Ｍ５；２５３−２７４（Ｓ）、ＴＭ６；２８６−３０６
（Ｓ）］ olfactory protein [Rattus norvegicus] (M64377)；17
4/311 (55%) 配列番号５４４［ＴＭ１；３９−６１（Ｐ）、ＴＭ２；
１１６−１３８（Ｐ）、ＴＭ３；１５２−１７４
（Ｐ）、ＴＭ４；２１４−２３６（Ｐ）、ＴＭ５；２５
３−２７４（Ｐ）、ＴＭ６；２８４−３０６（Ｓ）］ olfactory receptor [Homo sapiens] (AJ003147)；171/
308 (55%) 配列番号５４６［ＴＭ１；３３−５５（Ｐ）、ＴＭ２；
６８−９０（Ｐ）、ＴＭ３；１００−１２２（Ｓ）、Ｔ
Ｍ４；１４３−１６５（Ｓ）、ＴＭ５；２０８−２３０
（Ｐ）、ＴＭ６；２４４−２６６（Ｓ）、ＴＭ７；２７
９−２９８（Ｓ）］ HGMP07J [Homo sapiens] >gi|228481|prf||1804351C ol
factory receptor HGMP07J [Homo sapiens] (X64995)；
143/297 (48%) 配列番号５４８［ＴＭ１；１７−３９（Ｐ）、ＴＭ２；
７０−９２（Ｓ）、ＴＭ３；９８−１２０（Ｐ）、ＴＭ
４；１４５−１６７（Ｐ）、ＴＭ５；２０２−２２４
（Ｐ）、ＴＭ６；２３８−２５９（Ｓ）］ olfactory receptor OR93Gib [Hylobates lar] (AF0455
80)；149/309 (48%) 配列番号５５０［ＴＭ１；１−１９（Ｓ）、ＴＭ２；２
７−４９（Ｐ）、ＴＭ３；１０３−１２５（Ｓ）、ＴＭ
４；１３９−１６１（Ｐ）、ＴＭ５；２０１−２２３
（Ｐ）、ＴＭ６；２３７−２５８（Ｓ）］ olfactory factor OR37 - rat(S29711)；148/305 (48%)
【００９７】配列番号５５２［ＴＭ１；３３−５４
（Ｐ）、ＴＭ２；６０−８２（Ｐ）、ＴＭ３；９５−１
１７（Ｐ）、ＴＭ４；１３３−１５５（Ｓ）、ＴＭ５；
２０２−２２４（Ｐ）、ＴＭ６；２３９−２６１
（Ｐ）、ＴＭ７；２７３−２９４（Ｓ）］ olfactory receptor E3 [Mus musculus] (AF102527)；1
59/223 (71%) 配列番号５５４［ＴＭ１；１９−４１（Ｓ）、ＴＭ２；
４９−７１（Ｐ）、ＴＭ３；８１−１０３（Ｓ）、ＴＭ
４；１２１−１４３（Ｐ）、ＴＭ５；１６３−１８５
（Ｓ）、ＴＭ６；２１６−２３８（Ｐ）、ＴＭ７；２６
０−２８２（Ｓ）、ＴＭ８；２９４−３１４（Ｓ）］ olfactory receptor E3 [Mus musculus] (AF102527)；1
68/223 (75%) 配列番号５５６［ＴＭ１；３３−５５（Ｐ）、ＴＭ２；
６５−８７（Ｐ）、ＴＭ３；１０１−１２３（Ｓ）、Ｔ
Ｍ４；１４９−１７１（Ｐ）、ＴＭ５；２０８−２３０
（Ｐ）、ＴＭ６；２４２−２６４（Ｐ）、ＴＭ７；２７
７−２９８（Ｓ）、ＴＭ８；３２０−３４２（Ｐ）］ olfactory receptor E3 [Mus musculus] (AF102527)；1
28/223 (57%) 配列番号５５８［ＴＭ１；４−２６（Ｓ）、ＴＭ２；３
４−５６（Ｓ）、ＴＭ３；６２−８４（Ｓ）、ＴＭ４；
１６５−１８７（Ｐ）、ＴＭ５；２０４−２２６
（Ｐ）、ＴＭ６；２３５−２５７（Ｓ）］ olfactory receptor E3 [Mus musculus] (AF102527)；1
47/223 (65%) 配列番号５６０［ＴＭ１；２５−４７（Ｐ）、ＴＭ２；
５７−７９（Ｓ）、ＴＭ３；９３−１１５（Ｐ）、ＴＭ
４；１３４−１５６（Ｓ）、ＴＭ５；２０１−２２３
（Ｓ）、ＴＭ６；２３４−２５６（Ｓ）、ＴＭ７；２６
９−２９１（Ｓ）］ olfactory receptor [Gorilla gorilla] (AF101764)；1
28/301 (42%)
（Ｐ）、ＴＭ２；６０−８２（Ｐ）、ＴＭ３；９５−１
１７（Ｐ）、ＴＭ４；１３３−１５５（Ｓ）、ＴＭ５；
２０２−２２４（Ｐ）、ＴＭ６；２３９−２６１
（Ｐ）、ＴＭ７；２７３−２９４（Ｓ）］ olfactory receptor E3 [Mus musculus] (AF102527)；1
59/223 (71%) 配列番号５５４［ＴＭ１；１９−４１（Ｓ）、ＴＭ２；
４９−７１（Ｐ）、ＴＭ３；８１−１０３（Ｓ）、ＴＭ
４；１２１−１４３（Ｐ）、ＴＭ５；１６３−１８５
（Ｓ）、ＴＭ６；２１６−２３８（Ｐ）、ＴＭ７；２６
０−２８２（Ｓ）、ＴＭ８；２９４−３１４（Ｓ）］ olfactory receptor E3 [Mus musculus] (AF102527)；1
68/223 (75%) 配列番号５５６［ＴＭ１；３３−５５（Ｐ）、ＴＭ２；
６５−８７（Ｐ）、ＴＭ３；１０１−１２３（Ｓ）、Ｔ
Ｍ４；１４９−１７１（Ｐ）、ＴＭ５；２０８−２３０
（Ｐ）、ＴＭ６；２４２−２６４（Ｐ）、ＴＭ７；２７
７−２９８（Ｓ）、ＴＭ８；３２０−３４２（Ｐ）］ olfactory receptor E3 [Mus musculus] (AF102527)；1
28/223 (57%) 配列番号５５８［ＴＭ１；４−２６（Ｓ）、ＴＭ２；３
４−５６（Ｓ）、ＴＭ３；６２−８４（Ｓ）、ＴＭ４；
１６５−１８７（Ｐ）、ＴＭ５；２０４−２２６
（Ｐ）、ＴＭ６；２３５−２５７（Ｓ）］ olfactory receptor E3 [Mus musculus] (AF102527)；1
47/223 (65%) 配列番号５６０［ＴＭ１；２５−４７（Ｐ）、ＴＭ２；
５７−７９（Ｓ）、ＴＭ３；９３−１１５（Ｐ）、ＴＭ
４；１３４−１５６（Ｓ）、ＴＭ５；２０１−２２３
（Ｓ）、ＴＭ６；２３４−２５６（Ｓ）、ＴＭ７；２６
９−２９１（Ｓ）］ olfactory receptor [Gorilla gorilla] (AF101764)；1
28/301 (42%)
【００９８】配列番号５６２［ＴＭ１；３４−５５
（Ｐ）、ＴＭ２；１０１−１２３（Ｓ）、ＴＭ３；１４
４−１６６（Ｓ）、ＴＭ４；２０８−２３０（Ｐ）、Ｔ
Ｍ５；２４４−２６６（Ｐ）、ＴＭ６；２７５−２９７
（Ｓ）］ olfactory receptor E3 [Mus musculus] (AF102527)；1
52/223 (68%) 配列番号５６４［ＴＭ１；３５−５７（Ｐ）、ＴＭ２；
９５−１１７（Ｓ）、ＴＭ３；１４２−１６４（Ｐ）、
ＴＭ４；１７０−１９２（Ｓ）、ＴＭ５；２０７−２２
９（Ｐ）、ＴＭ６；２３８−２６０（Ｐ）］ olfactory receptor [Mus musculus] (AJ251155)；256/
312 (82%) 配列番号５６６［ＴＭ１；１９−４１（Ｐ）、ＴＭ２；
６１−８３（Ｐ）、ＴＭ３；９５−１１７（Ｓ）、ＴＭ
４；１４１−１６３（Ｓ）、ＴＭ５；２０１−２２３
（Ｐ）、ＴＭ６；２３９−２６０（Ｓ）］ HGMP07J [Homo sapiens] >gi|228481|prf||1804351C ol
factory receptor HGMP07J [Homo sapiens] (X64995)；
157/309 (50%) 配列番号５６８［ＴＭ１；２４−４６（Ｐ）、ＴＭ２；
５７−７９（Ｓ）、ＴＭ３；９２−１１４（Ｓ）、ＴＭ
４；１４１−１６３（Ｐ）、ＴＭ５；２０２−２２４
（Ｐ）、ＴＭ６；２３９−２６１（Ｓ）、ＴＭ７；２６
８−２９０（Ｓ）］ olfactory protein [Rattus norvegicus] (M64378)；20
8/304 (68%) 配列番号５７０［ＴＭ１；６３−８５（Ｐ）、ＴＭ２；
９８−１２０（Ｓ）、ＴＭ３；１４５−１６７（Ｓ）、
ＴＭ４；１７９−２０１（Ｓ）、ＴＭ５；２４３−２６
５（Ｐ）、ＴＭ６；２８１−３０２（Ｓ）］ olfactory receptor [Mus musculus] (M84005)；191/30
5 (62%)
（Ｐ）、ＴＭ２；１０１−１２３（Ｓ）、ＴＭ３；１４
４−１６６（Ｓ）、ＴＭ４；２０８−２３０（Ｐ）、Ｔ
Ｍ５；２４４−２６６（Ｐ）、ＴＭ６；２７５−２９７
（Ｓ）］ olfactory receptor E3 [Mus musculus] (AF102527)；1
52/223 (68%) 配列番号５６４［ＴＭ１；３５−５７（Ｐ）、ＴＭ２；
９５−１１７（Ｓ）、ＴＭ３；１４２−１６４（Ｐ）、
ＴＭ４；１７０−１９２（Ｓ）、ＴＭ５；２０７−２２
９（Ｐ）、ＴＭ６；２３８−２６０（Ｐ）］ olfactory receptor [Mus musculus] (AJ251155)；256/
312 (82%) 配列番号５６６［ＴＭ１；１９−４１（Ｐ）、ＴＭ２；
６１−８３（Ｐ）、ＴＭ３；９５−１１７（Ｓ）、ＴＭ
４；１４１−１６３（Ｓ）、ＴＭ５；２０１−２２３
（Ｐ）、ＴＭ６；２３９−２６０（Ｓ）］ HGMP07J [Homo sapiens] >gi|228481|prf||1804351C ol
factory receptor HGMP07J [Homo sapiens] (X64995)；
157/309 (50%) 配列番号５６８［ＴＭ１；２４−４６（Ｐ）、ＴＭ２；
５７−７９（Ｓ）、ＴＭ３；９２−１１４（Ｓ）、ＴＭ
４；１４１−１６３（Ｐ）、ＴＭ５；２０２−２２４
（Ｐ）、ＴＭ６；２３９−２６１（Ｓ）、ＴＭ７；２６
８−２９０（Ｓ）］ olfactory protein [Rattus norvegicus] (M64378)；20
8/304 (68%) 配列番号５７０［ＴＭ１；６３−８５（Ｐ）、ＴＭ２；
９８−１２０（Ｓ）、ＴＭ３；１４５−１６７（Ｓ）、
ＴＭ４；１７９−２０１（Ｓ）、ＴＭ５；２４３−２６
５（Ｐ）、ＴＭ６；２８１−３０２（Ｓ）］ olfactory receptor [Mus musculus] (M84005)；191/30
5 (62%)
【００９９】配列番号５７２［ＴＭ１；１３−３５
（Ｓ）、ＴＭ２；５９−８１（Ｓ）、ＴＭ３；１０２−
１２４（Ｓ）、ＴＭ４；１６６−１８８（Ｐ）、ＴＭ
５；２０１−２２３（Ｓ）、ＴＭ６；２３７−２５７
（Ｓ）］ OL1 receptor [Rattus norvegicus] (L34074)；120/270
(44%) 配列番号５７４［ＴＭ１；１５−３７（Ｓ）、ＴＭ２；
５２−７４（Ｓ）、ＴＭ３；９９−１２１（Ｓ）、ＴＭ
４；１６２−１８４（Ｐ）、ＴＭ５；１９５−２１６
（Ｓ）、ＴＭ６；２２７−２４９（Ｓ）、ＴＭ７；２５
２−２７４（Ｐ）、ＴＭ８；２７７−２９９（Ｐ）］ olfactory receptor G7 [Mus musculus] (AF102537)；1
33/223 (59%) 配列番号５７６［ＴＭ１；１９−４１（Ｐ）、ＴＭ２；
５７−７９（Ｓ）、ＴＭ３；９４−１１６（Ｓ）、ＴＭ
４；１３９−１６１（Ｓ）、ＴＭ５；２０２−２２４
（Ｐ）、ＴＭ６；２４０−２６０（Ｓ）、ＴＭ７；２７
６−２９８（Ｓ）］ olfactory receptor P2 [Mus musculus] (AF247657)；1
35/301 (44%) 配列番号５７８［ＴＭ１；２８−５０（Ｐ）、ＴＭ２；
６２−８４（Ｓ）、ＴＭ３；９８−１２０（Ｐ）、ＴＭ
４；１４４−１６６（Ｐ）、ＴＭ５；２０９−２３１
（Ｓ）、ＴＭ６；２４２−２６４（Ｐ）］ olfactory protein [Rattus norvegicus] (M64377)；17
5/309 (56%) 配列番号５８０［ＴＭ１；１−２３（Ｓ）、ＴＭ２；５
１−７３（Ｐ）、ＴＭ３；１１９−１４１（Ｓ）、ＴＭ
４；１６６−１８７（Ｓ）、ＴＭ５；２０４−２２６
（Ｓ）、ＴＭ６；２３５−２５７（Ｐ）、ＴＭ７；２７
２−２９４（Ｓ）］ CfOLF2 [Canis familiaris] (U53680)；168/293 (57%)
（Ｓ）、ＴＭ２；５９−８１（Ｓ）、ＴＭ３；１０２−
１２４（Ｓ）、ＴＭ４；１６６−１８８（Ｐ）、ＴＭ
５；２０１−２２３（Ｓ）、ＴＭ６；２３７−２５７
（Ｓ）］ OL1 receptor [Rattus norvegicus] (L34074)；120/270
(44%) 配列番号５７４［ＴＭ１；１５−３７（Ｓ）、ＴＭ２；
５２−７４（Ｓ）、ＴＭ３；９９−１２１（Ｓ）、ＴＭ
４；１６２−１８４（Ｐ）、ＴＭ５；１９５−２１６
（Ｓ）、ＴＭ６；２２７−２４９（Ｓ）、ＴＭ７；２５
２−２７４（Ｐ）、ＴＭ８；２７７−２９９（Ｐ）］ olfactory receptor G7 [Mus musculus] (AF102537)；1
33/223 (59%) 配列番号５７６［ＴＭ１；１９−４１（Ｐ）、ＴＭ２；
５７−７９（Ｓ）、ＴＭ３；９４−１１６（Ｓ）、ＴＭ
４；１３９−１６１（Ｓ）、ＴＭ５；２０２−２２４
（Ｐ）、ＴＭ６；２４０−２６０（Ｓ）、ＴＭ７；２７
６−２９８（Ｓ）］ olfactory receptor P2 [Mus musculus] (AF247657)；1
35/301 (44%) 配列番号５７８［ＴＭ１；２８−５０（Ｐ）、ＴＭ２；
６２−８４（Ｓ）、ＴＭ３；９８−１２０（Ｐ）、ＴＭ
４；１４４−１６６（Ｐ）、ＴＭ５；２０９−２３１
（Ｓ）、ＴＭ６；２４２−２６４（Ｐ）］ olfactory protein [Rattus norvegicus] (M64377)；17
5/309 (56%) 配列番号５８０［ＴＭ１；１−２３（Ｓ）、ＴＭ２；５
１−７３（Ｐ）、ＴＭ３；１１９−１４１（Ｓ）、ＴＭ
４；１６６−１８７（Ｓ）、ＴＭ５；２０４−２２６
（Ｓ）、ＴＭ６；２３５−２５７（Ｐ）、ＴＭ７；２７
２−２９４（Ｓ）］ CfOLF2 [Canis familiaris] (U53680)；168/293 (57%)
【０１００】配列番号５８２［ＴＭ１；３２−５４
（Ｐ）、ＴＭ２；９４−１１６（Ｓ）、ＴＭ３；１４５
−１６７（Ｐ）、ＴＭ４；２００−２２２（Ｐ）、ＴＭ
５；２４６−２６８（Ｓ）、ＴＭ６；２７０−２９２
（Ｓ）］ olfactory receptor [Pan troglodytes] (AF101741)；1
84/307 (59%) 配列番号５８４［ＴＭ１；５５−７７（Ｐ）、ＴＭ２；
９１−１１３（Ｓ）、ＴＭ３；１２４−１４６（Ｐ）、
ＴＭ４；１７２−１９４（Ｓ）、ＴＭ５；２０９−２３
１（Ｐ）、ＴＭ６；２３８−２６０（Ｐ）、ＴＭ７；２
６５−２８７（Ｐ）、ＴＭ８；２９８−３２０（Ｓ）］ olfactory receptor [Mus musculus] (AJ251155)；179/
306 (58%) 配列番号５８６［ＴＭ１；２７−４９（Ｐ）、ＴＭ２；
８７−１０９（Ｐ）、ＴＭ３；１２６−１４８（Ｓ）、
ＴＭ４；１５３−１７５（Ｓ）、ＴＭ５；２０２−２２
４（Ｐ）、ＴＭ６；２３９−２６０（Ｓ）、ＴＭ７；２
７２−２９４（Ｓ）］ olfactory receptor [Rattus norvegicus] (X80671)；1
51/300 (50%) 配列番号５８８［ＴＭ１；２８−５０（Ｐ）、ＴＭ２；
９８−１２０（Ｐ）、ＴＭ３；１４０−１６２（Ｐ）、
ＴＭ４；２０６−２２７（Ｐ）、ＴＭ５；２４０−２６
２（Ｓ）、ＴＭ６；２７１−２９３（Ｓ）］ olfactory receptor OR93Ch [Pan troglodytes] (AF045
577)；161/304 (52%) 配列番号５９０［ＴＭ１；１１−３３（Ｓ）、ＴＭ２；
５２−７３（Ｓ）、ＴＭ３；９８−１２０（Ｐ）、ＴＭ
４；１３５−１５７（Ｓ）、ＴＭ５；１６３−１８４
（Ｐ）、ＴＭ６；２２５−２４７（Ｓ）］ HGMP07J [Homo sapiens] >gi|228481|prf||1804351C ol
factory receptor HGMP07J [Homo sapiens] (X64995)；
119/261 (45%)
（Ｐ）、ＴＭ２；９４−１１６（Ｓ）、ＴＭ３；１４５
−１６７（Ｐ）、ＴＭ４；２００−２２２（Ｐ）、ＴＭ
５；２４６−２６８（Ｓ）、ＴＭ６；２７０−２９２
（Ｓ）］ olfactory receptor [Pan troglodytes] (AF101741)；1
84/307 (59%) 配列番号５８４［ＴＭ１；５５−７７（Ｐ）、ＴＭ２；
９１−１１３（Ｓ）、ＴＭ３；１２４−１４６（Ｐ）、
ＴＭ４；１７２−１９４（Ｓ）、ＴＭ５；２０９−２３
１（Ｐ）、ＴＭ６；２３８−２６０（Ｐ）、ＴＭ７；２
６５−２８７（Ｐ）、ＴＭ８；２９８−３２０（Ｓ）］ olfactory receptor [Mus musculus] (AJ251155)；179/
306 (58%) 配列番号５８６［ＴＭ１；２７−４９（Ｐ）、ＴＭ２；
８７−１０９（Ｐ）、ＴＭ３；１２６−１４８（Ｓ）、
ＴＭ４；１５３−１７５（Ｓ）、ＴＭ５；２０２−２２
４（Ｐ）、ＴＭ６；２３９−２６０（Ｓ）、ＴＭ７；２
７２−２９４（Ｓ）］ olfactory receptor [Rattus norvegicus] (X80671)；1
51/300 (50%) 配列番号５８８［ＴＭ１；２８−５０（Ｐ）、ＴＭ２；
９８−１２０（Ｐ）、ＴＭ３；１４０−１６２（Ｐ）、
ＴＭ４；２０６−２２７（Ｐ）、ＴＭ５；２４０−２６
２（Ｓ）、ＴＭ６；２７１−２９３（Ｓ）］ olfactory receptor OR93Ch [Pan troglodytes] (AF045
577)；161/304 (52%) 配列番号５９０［ＴＭ１；１１−３３（Ｓ）、ＴＭ２；
５２−７３（Ｓ）、ＴＭ３；９８−１２０（Ｐ）、ＴＭ
４；１３５−１５７（Ｓ）、ＴＭ５；１６３−１８４
（Ｐ）、ＴＭ６；２２５−２４７（Ｓ）］ HGMP07J [Homo sapiens] >gi|228481|prf||1804351C ol
factory receptor HGMP07J [Homo sapiens] (X64995)；
119/261 (45%)
【０１０１】配列番号５９２［ＴＭ１；１−２３
（Ｐ）、ＴＭ２；４２−６４（Ｓ）、ＴＭ３；７６−９
８（Ｓ）、ＴＭ４；１０７−１２９（Ｐ）、ＴＭ５；１
３７−１５８（Ｓ）、ＴＭ６；１７６−１９８（Ｓ）］ olfactory receptor [Mus musculus] (AJ251154)；188/
216 (87%) 配列番号５９４［ＴＭ１；１１−３３（Ｐ）、ＴＭ２；
４７−６９（Ｓ）、ＴＭ３；９４−１１６（Ｐ）、ＴＭ
４；１４０−１６２（Ｐ）、ＴＭ５；１６８−１８９
（Ｓ）、ＴＭ６；１９５−２０８（Ｓ）］ similar to mouse olfactory receptor 13; similar to
P34984 (PID:g464305)[Homo sapiens] (AC005587)；12
6/208 (60%) 配列番号５９６［ＴＭ１；１７−３９（Ｐ）、ＴＭ２；
８４−１０６（Ｐ）、ＴＭ３；１２６−１４７（Ｓ）、
ＴＭ４；１４９−１７１（Ｓ）、ＴＭ５；２０１−２２
３（Ｓ）、ＴＭ６；２５８−２８０（Ｐ）、ＴＭ７；２
９８−３２０（Ｓ）、ＴＭ８；３３０−３５２（Ｓ）］ olfactory receptor [Mus musculus] (M84005)；182/30
5 (59%) 配列番号５９８［ＴＭ１；１６−３８（Ｐ）、ＴＭ２；
９４−１１６（Ｓ）、ＴＭ３；１４０−１６２（Ｐ）、
ＴＭ４；１７１−１９３（Ｓ）、ＴＭ５；２００−２２
２（Ｐ）、ＴＭ６；２３９−２６１（Ｓ）］ similar to mouse olfactory receptor 13; similar to
P34984 (PID:g464305)[Homo sapiens] (AC005587)；18
3/251 (72%) 配列番号６００［ＴＭ１；３２−５４（Ｐ）、ＴＭ２；
９５−１１７（Ｐ）、ＴＭ３；１３９−１６１（Ｓ）、
ＴＭ４；１９６−２１８（Ｐ）、ＴＭ５；２４２−２６
４（Ｓ）、ＴＭ６；２７６−２９８（Ｓ）］ HsOLF3 [Homo sapiens] (U56421)；135/305 (44%)
（Ｐ）、ＴＭ２；４２−６４（Ｓ）、ＴＭ３；７６−９
８（Ｓ）、ＴＭ４；１０７−１２９（Ｐ）、ＴＭ５；１
３７−１５８（Ｓ）、ＴＭ６；１７６−１９８（Ｓ）］ olfactory receptor [Mus musculus] (AJ251154)；188/
216 (87%) 配列番号５９４［ＴＭ１；１１−３３（Ｐ）、ＴＭ２；
４７−６９（Ｓ）、ＴＭ３；９４−１１６（Ｐ）、ＴＭ
４；１４０−１６２（Ｐ）、ＴＭ５；１６８−１８９
（Ｓ）、ＴＭ６；１９５−２０８（Ｓ）］ similar to mouse olfactory receptor 13; similar to
P34984 (PID:g464305)[Homo sapiens] (AC005587)；12
6/208 (60%) 配列番号５９６［ＴＭ１；１７−３９（Ｐ）、ＴＭ２；
８４−１０６（Ｐ）、ＴＭ３；１２６−１４７（Ｓ）、
ＴＭ４；１４９−１７１（Ｓ）、ＴＭ５；２０１−２２
３（Ｓ）、ＴＭ６；２５８−２８０（Ｐ）、ＴＭ７；２
９８−３２０（Ｓ）、ＴＭ８；３３０−３５２（Ｓ）］ olfactory receptor [Mus musculus] (M84005)；182/30
5 (59%) 配列番号５９８［ＴＭ１；１６−３８（Ｐ）、ＴＭ２；
９４−１１６（Ｓ）、ＴＭ３；１４０−１６２（Ｐ）、
ＴＭ４；１７１−１９３（Ｓ）、ＴＭ５；２００−２２
２（Ｐ）、ＴＭ６；２３９−２６１（Ｓ）］ similar to mouse olfactory receptor 13; similar to
P34984 (PID:g464305)[Homo sapiens] (AC005587)；18
3/251 (72%) 配列番号６００［ＴＭ１；３２−５４（Ｐ）、ＴＭ２；
９５−１１７（Ｐ）、ＴＭ３；１３９−１６１（Ｓ）、
ＴＭ４；１９６−２１８（Ｐ）、ＴＭ５；２４２−２６
４（Ｓ）、ＴＭ６；２７６−２９８（Ｓ）］ HsOLF3 [Homo sapiens] (U56421)；135/305 (44%)
【０１０２】配列番号６０２［ＴＭ１；１９−４１
（Ｐ）、ＴＭ２；６１−８３（Ｐ）、ＴＭ３；９４−１
１６（Ｓ）、ＴＭ４；１４８−１７０（Ｐ）、ＴＭ５；
１８０−２０２（Ｓ）、ＴＭ６；２１１−２３３
（Ｐ）、ＴＭ７；２４１−２６２（Ｓ）、ＴＭ８；２７
３−２９４（Ｓ）］ R30385_1 [Homo sapiens] (AC004510)；293/313 (93%) 配列番号６０４［ＴＭ１；７３−９５（Ｓ）、ＴＭ２；
１４６−１６８（Ｓ）、ＴＭ３；１９１−２１３
（Ｓ）、ＴＭ４；２４５−２６７（Ｐ）、ＴＭ５；２９
１−３１２（Ｐ）、ＴＭ６；３２４−３４４（Ｓ）］ olfactory receptor 4 [Gallus gallus] (X94744)；169
/310 (54%) 配列番号６０６［ＴＭ１；１−２１（Ｓ）、ＴＭ２；４
５−６７（Ｐ）、ＴＭ３；７３−９５（Ｓ）、ＴＭ４；
１０６−１２８（Ｓ）、ＴＭ５；１６１−１８３
（Ｐ）、ＴＭ６；２２３−２４５（Ｐ）、ＴＭ７；２５
８−２８０（Ｓ）、ＴＭ８；２９０−３１１（Ｓ）］ odorant receptor S1 [Mus musculus] (AF121972)；215
/315 (68%) 配列番号６０８［ＴＭ１；４１−６３（Ｐ）、ＴＭ２；
７１−９３（Ｓ）、ＴＭ３；１０５−１２７（Ｐ）、Ｔ
Ｍ４；１４９−１７１（Ｐ）、ＴＭ５；２１６−２３８
（Ｐ）、ＴＭ６；２４９−２７１（Ｐ）、ＴＭ７；２７
９−３０１（Ｓ）］ odorant receptor S1 [Mus musculus] (AF121972)；278
/317 (87%) 配列番号６１０［ＴＭ１；２９−５０（Ｐ）、ＴＭ２；
５９−８１（Ｐ）、ＴＭ３；９６−１１８（Ｓ）、ＴＭ
４；１４４−１６６（Ｐ）、ＴＭ５；２０３−２２４
（Ｐ）、ＴＭ６；２４０−２６２（Ｐ）、ＴＭ７；２６
９−２９１（Ｓ）］ odorant receptor MOR83 [Mus musculus] (AB030894)；
167/308 (54%)
（Ｐ）、ＴＭ２；６１−８３（Ｐ）、ＴＭ３；９４−１
１６（Ｓ）、ＴＭ４；１４８−１７０（Ｐ）、ＴＭ５；
１８０−２０２（Ｓ）、ＴＭ６；２１１−２３３
（Ｐ）、ＴＭ７；２４１−２６２（Ｓ）、ＴＭ８；２７
３−２９４（Ｓ）］ R30385_1 [Homo sapiens] (AC004510)；293/313 (93%) 配列番号６０４［ＴＭ１；７３−９５（Ｓ）、ＴＭ２；
１４６−１６８（Ｓ）、ＴＭ３；１９１−２１３
（Ｓ）、ＴＭ４；２４５−２６７（Ｐ）、ＴＭ５；２９
１−３１２（Ｐ）、ＴＭ６；３２４−３４４（Ｓ）］ olfactory receptor 4 [Gallus gallus] (X94744)；169
/310 (54%) 配列番号６０６［ＴＭ１；１−２１（Ｓ）、ＴＭ２；４
５−６７（Ｐ）、ＴＭ３；７３−９５（Ｓ）、ＴＭ４；
１０６−１２８（Ｓ）、ＴＭ５；１６１−１８３
（Ｐ）、ＴＭ６；２２３−２４５（Ｐ）、ＴＭ７；２５
８−２８０（Ｓ）、ＴＭ８；２９０−３１１（Ｓ）］ odorant receptor S1 [Mus musculus] (AF121972)；215
/315 (68%) 配列番号６０８［ＴＭ１；４１−６３（Ｐ）、ＴＭ２；
７１−９３（Ｓ）、ＴＭ３；１０５−１２７（Ｐ）、Ｔ
Ｍ４；１４９−１７１（Ｐ）、ＴＭ５；２１６−２３８
（Ｐ）、ＴＭ６；２４９−２７１（Ｐ）、ＴＭ７；２７
９−３０１（Ｓ）］ odorant receptor S1 [Mus musculus] (AF121972)；278
/317 (87%) 配列番号６１０［ＴＭ１；２９−５０（Ｐ）、ＴＭ２；
５９−８１（Ｐ）、ＴＭ３；９６−１１８（Ｓ）、ＴＭ
４；１４４−１６６（Ｐ）、ＴＭ５；２０３−２２４
（Ｐ）、ＴＭ６；２４０−２６２（Ｐ）、ＴＭ７；２６
９−２９１（Ｓ）］ odorant receptor MOR83 [Mus musculus] (AB030894)；
167/308 (54%)
【０１０３】配列番号６１２［ＴＭ１；５６−７８
（Ｓ）、ＴＭ２；９７−１１９（Ｓ）、ＴＭ３；１３６
−１５８（Ｐ）、ＴＭ４；１８４−２０６（Ｐ）、ＴＭ
５；２３９−２６１（Ｐ）、ＴＭ６；２７８−２９９
（Ｓ）、ＴＭ７；３１０−３３１（Ｓ）］ odorant receptor S1 [Mus musculus] (AF121972)；195
/293 (66%) 配列番号６１４［ＴＭ１；２６−４８（Ｐ）、ＴＭ２；
６０−８２（Ｓ）、ＴＭ３；９３−１１５（Ｓ）、ＴＭ
４；１４１−１６３（Ｐ）、ＴＭ５；２０６−２２８
（Ｐ）、ＴＭ６；２３８−２５９（Ｓ）、ＴＭ７；２６
８−２９０（Ｓ）］ olfactory receptor C6 [Mus musculus] (AF102523)；1
48/299 (49%) 配列番号６１６［ＴＭ１；１９−４１（Ｓ）、ＴＭ２；
６２−８４（Ｓ）、ＴＭ３；１００−１２２（Ｓ）、Ｔ
Ｍ４；１４０−１６２（Ｐ）、ＴＭ５；２０２−２２４
（Ｐ）、ＴＭ６；２４２−２６４（Ｓ）］ BC62940_2 [Homo sapiens] (AC004659)；214/310 (69%) 配列番号６１８［ＴＭ１；３３−５５（Ｐ）、ＴＭ２；
６４−８６（Ｓ）、ＴＭ３；１００−１２２（Ｓ）、Ｔ
Ｍ４；１３７−１５９（Ｐ）、ＴＭ５；２０７−２２９
（Ｐ）、ＴＭ６；２４５−２６７（Ｐ）、ＴＭ７；２７
３−２９５（Ｓ）］ taste bud receptor protein TB 641 [Rattus norvegic
us] (U50949)；270/310(87%) 配列番号６２０［ＴＭ１；３−２５（Ｐ）、ＴＭ２；３
０−５１（Ｓ）、ＴＭ３；５３−７４（Ｓ）、ＴＭ４；
８１−９５（Ｓ）、ＴＭ５；１０１−１２２（Ｓ）、Ｔ
Ｍ６；１４４−１６６（Ｐ）、ＴＭ７；１８３−２０５
（Ｐ）、ＴＭ８；２１４−２３５（Ｓ）］ olfactory receptor [Callithrix jacchus] (AF12788
2)；200/216 (92%)
（Ｓ）、ＴＭ２；９７−１１９（Ｓ）、ＴＭ３；１３６
−１５８（Ｐ）、ＴＭ４；１８４−２０６（Ｐ）、ＴＭ
５；２３９−２６１（Ｐ）、ＴＭ６；２７８−２９９
（Ｓ）、ＴＭ７；３１０−３３１（Ｓ）］ odorant receptor S1 [Mus musculus] (AF121972)；195
/293 (66%) 配列番号６１４［ＴＭ１；２６−４８（Ｐ）、ＴＭ２；
６０−８２（Ｓ）、ＴＭ３；９３−１１５（Ｓ）、ＴＭ
４；１４１−１６３（Ｐ）、ＴＭ５；２０６−２２８
（Ｐ）、ＴＭ６；２３８−２５９（Ｓ）、ＴＭ７；２６
８−２９０（Ｓ）］ olfactory receptor C6 [Mus musculus] (AF102523)；1
48/299 (49%) 配列番号６１６［ＴＭ１；１９−４１（Ｓ）、ＴＭ２；
６２−８４（Ｓ）、ＴＭ３；１００−１２２（Ｓ）、Ｔ
Ｍ４；１４０−１６２（Ｐ）、ＴＭ５；２０２−２２４
（Ｐ）、ＴＭ６；２４２−２６４（Ｓ）］ BC62940_2 [Homo sapiens] (AC004659)；214/310 (69%) 配列番号６１８［ＴＭ１；３３−５５（Ｐ）、ＴＭ２；
６４−８６（Ｓ）、ＴＭ３；１００−１２２（Ｓ）、Ｔ
Ｍ４；１３７−１５９（Ｐ）、ＴＭ５；２０７−２２９
（Ｐ）、ＴＭ６；２４５−２６７（Ｐ）、ＴＭ７；２７
３−２９５（Ｓ）］ taste bud receptor protein TB 641 [Rattus norvegic
us] (U50949)；270/310(87%) 配列番号６２０［ＴＭ１；３−２５（Ｐ）、ＴＭ２；３
０−５１（Ｓ）、ＴＭ３；５３−７４（Ｓ）、ＴＭ４；
８１−９５（Ｓ）、ＴＭ５；１０１−１２２（Ｓ）、Ｔ
Ｍ６；１４４−１６６（Ｐ）、ＴＭ７；１８３−２０５
（Ｐ）、ＴＭ８；２１４−２３５（Ｓ）］ olfactory receptor [Callithrix jacchus] (AF12788
2)；200/216 (92%)
【０１０４】配列番号６２２［ＴＭ１；３−２５
（Ｐ）、ＴＭ２；３０−５１（Ｐ）、ＴＭ３；５４−７
５（Ｓ）、ＴＭ４；７８−９６（Ｓ）、ＴＭ５；１０２
−１２３（Ｓ）、ＴＭ６；１４４−１６６（Ｐ）、ＴＭ
７；１８３−２０５（Ｐ）、ＴＭ８；２１４−２３５
（Ｓ）］ olfactory receptor [Eulemur rubriventer] (AF12786
1)；200/216 (92%) 配列番号６２４［ＴＭ１；１６−３８（Ｐ）、ＴＭ２；
９４−１１６（Ｓ）、ＴＭ３；１４０−１６２（Ｐ）、
ＴＭ４；１７１−１９３（Ｓ）、ＴＭ５；２００−２２
２（Ｐ）、ＴＭ６；２３９−２６０（Ｐ）］ similar to mouse olfactory receptor 13; similar to
P34984 (PID:g464305)[Homo sapiens] (AC005587)；21
7/307 (70%) 配列番号６２６［ＴＭ１；１−２３（Ｐ）、ＴＭ２；５
２−７４（Ｐ）、ＴＭ３；１２０−１４２（Ｓ）、ＴＭ
４；１６８−１９０（Ｐ）、ＴＭ５；２３０−２５１
（Ｐ）、ＴＭ６；２６２−２８４（Ｐ）］ odorant receptor MOR18 [Mus musculus] (AB030895)；
158/299 (52%) 配列番号６２８［ＴＭ１；２７−４９（Ｐ）、ＴＭ２；
６２−８４（Ｓ）、ＴＭ３；９８−１２０（Ｓ）、ＴＭ
４；１４５−１６７（Ｐ）、ＴＭ５；２０５−２２６
（Ｐ）、ＴＭ６；２３７−２５９（Ｐ）］ odorant receptor MOR18 [Mus musculus] (AB030895)；
149/293 (50%) 配列番号６３０［ＴＭ１；３９−６１（Ｐ）、ＴＭ２；
８０−１０２（Ｓ）、ＴＭ３；１１５−１３７（Ｐ）、
ＴＭ４；１６０−１８２（Ｐ）、ＴＭ５；１９０−２１
２（Ｓ）、ＴＭ６；２２５−２４６（Ｐ）、ＴＭ７；２
６１−２８３（Ｐ）、ＴＭ８；２８８−３１０（Ｐ）］ similar to rat olfactory receptor OR18; similar to
S29710 (PID:g423702)[Homo sapiens] (AC004908)；16
4/302 (54%)
（Ｐ）、ＴＭ２；３０−５１（Ｐ）、ＴＭ３；５４−７
５（Ｓ）、ＴＭ４；７８−９６（Ｓ）、ＴＭ５；１０２
−１２３（Ｓ）、ＴＭ６；１４４−１６６（Ｐ）、ＴＭ
７；１８３−２０５（Ｐ）、ＴＭ８；２１４−２３５
（Ｓ）］ olfactory receptor [Eulemur rubriventer] (AF12786
1)；200/216 (92%) 配列番号６２４［ＴＭ１；１６−３８（Ｐ）、ＴＭ２；
９４−１１６（Ｓ）、ＴＭ３；１４０−１６２（Ｐ）、
ＴＭ４；１７１−１９３（Ｓ）、ＴＭ５；２００−２２
２（Ｐ）、ＴＭ６；２３９−２６０（Ｐ）］ similar to mouse olfactory receptor 13; similar to
P34984 (PID:g464305)[Homo sapiens] (AC005587)；21
7/307 (70%) 配列番号６２６［ＴＭ１；１−２３（Ｐ）、ＴＭ２；５
２−７４（Ｐ）、ＴＭ３；１２０−１４２（Ｓ）、ＴＭ
４；１６８−１９０（Ｐ）、ＴＭ５；２３０−２５１
（Ｐ）、ＴＭ６；２６２−２８４（Ｐ）］ odorant receptor MOR18 [Mus musculus] (AB030895)；
158/299 (52%) 配列番号６２８［ＴＭ１；２７−４９（Ｐ）、ＴＭ２；
６２−８４（Ｓ）、ＴＭ３；９８−１２０（Ｓ）、ＴＭ
４；１４５−１６７（Ｐ）、ＴＭ５；２０５−２２６
（Ｐ）、ＴＭ６；２３７−２５９（Ｐ）］ odorant receptor MOR18 [Mus musculus] (AB030895)；
149/293 (50%) 配列番号６３０［ＴＭ１；３９−６１（Ｐ）、ＴＭ２；
８０−１０２（Ｓ）、ＴＭ３；１１５−１３７（Ｐ）、
ＴＭ４；１６０−１８２（Ｐ）、ＴＭ５；１９０−２１
２（Ｓ）、ＴＭ６；２２５−２４６（Ｐ）、ＴＭ７；２
６１−２８３（Ｐ）、ＴＭ８；２８８−３１０（Ｐ）］ similar to rat olfactory receptor OR18; similar to
S29710 (PID:g423702)[Homo sapiens] (AC004908)；16
4/302 (54%)
【０１０５】配列番号６３２［ＴＭ１；３１−５３
（Ｐ）、ＴＭ２；６２−８４（Ｓ）、ＴＭ３；１０１−
１２３（Ｓ）、ＴＭ４；１３３−１５５（Ｓ）、ＴＭ
５；１６４−１８６（Ｓ）、ＴＭ６；２００−２２２
（Ｐ）、ＴＭ７；２３８−２６０（Ｐ）、ＴＭ８；２６
８−２９０（Ｓ）］ odorant receptor MOR83 [Mus musculus] (AB030894)；
164/307 (53%) 配列番号６３４［ＴＭ１；２７−４９（Ｐ）、ＴＭ２；
９２−１１４（Ｐ）、ＴＭ３；１３３−１５５（Ｐ）、
ＴＭ４；２００−２２２（Ｐ）、ＴＭ５；２３７−２５
８（Ｓ）、ＴＭ６；２６６−２８８（Ｓ）］ odorant receptor MOR83 [Mus musculus] (AB030894)；
262/306 (85%) 配列番号６３６［ＴＭ１；５−２７（Ｐ）、ＴＭ２；３
３−５５（Ｓ）、ＴＭ３；５９−８１（Ｓ）、ＴＭ４；
８３−１０５（Ｓ）、ＴＭ５；１１４−１３６（Ｓ）、
ＴＭ６；１４４−１６６（Ｐ）、ＴＭ７；１８０−２０
１（Ｓ）、ＴＭ８；２１４−２３６（Ｓ）］ taste bud receptor protein TB 641 [Rattus norvegic
us] (U50949)；189/244(77%) 配列番号６３８［ＴＭ１；７−２９（Ｓ）、ＴＭ２；６
７−８９（Ｓ）、ＴＭ３；１０２−１２４（Ｐ）、ＴＭ
４；１６６−１８８（Ｓ）、ＴＭ５；２０９−２３１
（Ｐ）、ＴＭ６；２３７−２５９（Ｓ）］ BC319430_5 [Homo sapiens] (AC006271)；183/260 (70
%) 配列番号６４０［ＴＭ１；２０−４２（Ｓ）、ＴＭ２；
４６−６７（Ｓ）、ＴＭ３；７２−９４（Ｓ）、ＴＭ
４；１１５−１３７（Ｓ）、ＴＭ５；１６０−１８２
（Ｐ）、ＴＭ６；２１８−２４０（Ｐ）、ＴＭ７；２５
６−２７８（Ｓ）、ＴＭ８；２９２−３１４（Ｓ）］ odorant receptor S1 [Mus musculus] (AF121972)；191
/314 (60%)
（Ｐ）、ＴＭ２；６２−８４（Ｓ）、ＴＭ３；１０１−
１２３（Ｓ）、ＴＭ４；１３３−１５５（Ｓ）、ＴＭ
５；１６４−１８６（Ｓ）、ＴＭ６；２００−２２２
（Ｐ）、ＴＭ７；２３８−２６０（Ｐ）、ＴＭ８；２６
８−２９０（Ｓ）］ odorant receptor MOR83 [Mus musculus] (AB030894)；
164/307 (53%) 配列番号６３４［ＴＭ１；２７−４９（Ｐ）、ＴＭ２；
９２−１１４（Ｐ）、ＴＭ３；１３３−１５５（Ｐ）、
ＴＭ４；２００−２２２（Ｐ）、ＴＭ５；２３７−２５
８（Ｓ）、ＴＭ６；２６６−２８８（Ｓ）］ odorant receptor MOR83 [Mus musculus] (AB030894)；
262/306 (85%) 配列番号６３６［ＴＭ１；５−２７（Ｐ）、ＴＭ２；３
３−５５（Ｓ）、ＴＭ３；５９−８１（Ｓ）、ＴＭ４；
８３−１０５（Ｓ）、ＴＭ５；１１４−１３６（Ｓ）、
ＴＭ６；１４４−１６６（Ｐ）、ＴＭ７；１８０−２０
１（Ｓ）、ＴＭ８；２１４−２３６（Ｓ）］ taste bud receptor protein TB 641 [Rattus norvegic
us] (U50949)；189/244(77%) 配列番号６３８［ＴＭ１；７−２９（Ｓ）、ＴＭ２；６
７−８９（Ｓ）、ＴＭ３；１０２−１２４（Ｐ）、ＴＭ
４；１６６−１８８（Ｓ）、ＴＭ５；２０９−２３１
（Ｐ）、ＴＭ６；２３７−２５９（Ｓ）］ BC319430_5 [Homo sapiens] (AC006271)；183/260 (70
%) 配列番号６４０［ＴＭ１；２０−４２（Ｓ）、ＴＭ２；
４６−６７（Ｓ）、ＴＭ３；７２−９４（Ｓ）、ＴＭ
４；１１５−１３７（Ｓ）、ＴＭ５；１６０−１８２
（Ｐ）、ＴＭ６；２１８−２４０（Ｐ）、ＴＭ７；２５
６−２７８（Ｓ）、ＴＭ８；２９２−３１４（Ｓ）］ odorant receptor S1 [Mus musculus] (AF121972)；191
/314 (60%)
【０１０６】配列番号６４２［ＴＭ１；２−２４
（Ｓ）、ＴＭ２；４８−７０（Ｐ）、ＴＭ３；１１６−
１３８（Ｓ）、ＴＭ４；１６２−１８４（Ｐ）、ＴＭ
５；１８８−２１０（Ｓ）、ＴＭ６；２２２−２４４
（Ｓ）、ＴＭ７；２６３−２８５（Ｓ）、ＴＭ８；３２
５−３４５（Ｐ）］ OLF4 [Homo sapiens] (AC002988)；200/302 (66%) 配列番号６４４［ＴＭ１；２５−４７（Ｐ）、ＴＭ２；
５８−８０（Ｓ）、ＴＭ３；１００−１２２（Ｐ）、Ｔ
Ｍ４；１４２−１６４（Ｐ）、ＴＭ５；１９３−２１５
（Ｐ）、ＴＭ６；２４１−２６２（Ｓ）、ＴＭ７；２７
２−２９３（Ｓ）］ BC85395_3 [Homo sapiens] (AC005255)；201/302 (66%) 配列番号６４６［ＴＭ１；１９−４１（Ｓ）、ＴＭ２；
９５−１１７（Ｐ）、ＴＭ３；１４３−１６５（Ｐ）、
ＴＭ４；１７０−１９２（Ｓ）、ＴＭ５；２００−２２
２（Ｓ）、ＴＭ６；２４１−２６３（Ｓ）］ BC85395_3 [Homo sapiens] (AC005255)；186/298 (62%) 配列番号６４８［ＴＭ１；２７−４９（Ｐ）、ＴＭ２；
６０−８２（Ｓ）、ＴＭ３；１００−１２２（Ｐ）、Ｔ
Ｍ４；１４３−１６５（Ｐ）、ＴＭ５；２１０−２３２
（Ｐ）、ＴＭ６；２４３−２６５（Ｓ）］ olfactory receptor [Papio hamadryas] (AF127819)；2
04/216 (94%) 配列番号６５０［ＴＭ１；３４−５６（Ｐ）、ＴＭ２；
６２−８４（Ｓ）、ＴＭ３；９８−１２０（Ｐ）、ＴＭ
４；１２４−１４６（Ｓ）、ＴＭ５；２０２−２２４
（Ｐ）、ＴＭ６；２３７−２５９（Ｓ）、ＴＭ７；２７
０−２９２（Ｓ）］ olfactory protein [Rattus norvegicus] (M64386)；17
7/308 (57%)
（Ｓ）、ＴＭ２；４８−７０（Ｐ）、ＴＭ３；１１６−
１３８（Ｓ）、ＴＭ４；１６２−１８４（Ｐ）、ＴＭ
５；１８８−２１０（Ｓ）、ＴＭ６；２２２−２４４
（Ｓ）、ＴＭ７；２６３−２８５（Ｓ）、ＴＭ８；３２
５−３４５（Ｐ）］ OLF4 [Homo sapiens] (AC002988)；200/302 (66%) 配列番号６４４［ＴＭ１；２５−４７（Ｐ）、ＴＭ２；
５８−８０（Ｓ）、ＴＭ３；１００−１２２（Ｐ）、Ｔ
Ｍ４；１４２−１６４（Ｐ）、ＴＭ５；１９３−２１５
（Ｐ）、ＴＭ６；２４１−２６２（Ｓ）、ＴＭ７；２７
２−２９３（Ｓ）］ BC85395_3 [Homo sapiens] (AC005255)；201/302 (66%) 配列番号６４６［ＴＭ１；１９−４１（Ｓ）、ＴＭ２；
９５−１１７（Ｐ）、ＴＭ３；１４３−１６５（Ｐ）、
ＴＭ４；１７０−１９２（Ｓ）、ＴＭ５；２００−２２
２（Ｓ）、ＴＭ６；２４１−２６３（Ｓ）］ BC85395_3 [Homo sapiens] (AC005255)；186/298 (62%) 配列番号６４８［ＴＭ１；２７−４９（Ｐ）、ＴＭ２；
６０−８２（Ｓ）、ＴＭ３；１００−１２２（Ｐ）、Ｔ
Ｍ４；１４３−１６５（Ｐ）、ＴＭ５；２１０−２３２
（Ｐ）、ＴＭ６；２４３−２６５（Ｓ）］ olfactory receptor [Papio hamadryas] (AF127819)；2
04/216 (94%) 配列番号６５０［ＴＭ１；３４−５６（Ｐ）、ＴＭ２；
６２−８４（Ｓ）、ＴＭ３；９８−１２０（Ｐ）、ＴＭ
４；１２４−１４６（Ｓ）、ＴＭ５；２０２−２２４
（Ｐ）、ＴＭ６；２３７−２５９（Ｓ）、ＴＭ７；２７
０−２９２（Ｓ）］ olfactory protein [Rattus norvegicus] (M64386)；17
7/308 (57%)
【０１０７】配列番号６５２［ＴＭ１；４１−６３
（Ｓ）、ＴＭ２；８２−１０４（Ｓ）、ＴＭ３；１１３
−１３４（Ｓ）、ＴＭ４；１４４−１６６（Ｐ）、ＴＭ
５；１８１−２０３（Ｐ）、ＴＭ６；２１０−２３２
（Ｓ）］ HGMP07J [Homo sapiens] >gi|228481|prf||1804351C ol
factory receptor HGMP07J [Homo sapiens] (X64995)；
124/248 (50%) 配列番号６５４［ＴＭ１；１２−３４（Ｐ）、ＴＭ２；
４５−６７（Ｓ）、ＴＭ３；１０１−１２３（Ｓ）、Ｔ
Ｍ４；１４４−１６６（Ｓ）、ＴＭ５；１９７−２１９
（Ｐ）、ＴＭ６；２４０−２６１（Ｓ）、ＴＭ７；２７
２−２９３（Ｓ）］ HGMP07J [Homo sapiens] >gi|228481|prf||1804351C ol
factory receptor HGMP07J [Homo sapiens] (X64995)；
165/308 (53%) 配列番号６５６［ＴＭ１；２８−５０（Ｐ）、ＴＭ２；
９４−１１６（Ｓ）、ＴＭ３；１３９−１６１（Ｓ）、
ＴＭ４；２０３−２２５（Ｐ）、ＴＭ５；２３９−２６
０（Ｐ）、ＴＭ６；２７１−２９３（Ｓ）］ olfactory receptor P2 [Mus musculus] (AF247657)；1
55/308 (50%) 配列番号６５８［ＴＭ１；５１−７３（Ｐ）、ＴＭ２；
８３−１０５（Ｐ）、ＴＭ３；１５６−１７８（Ｐ）、
ＴＭ４；２０２−２２４（Ｐ）、ＴＭ５；２２９−２５
０（Ｐ）、ＴＭ６；２６５−２８７（Ｐ）、ＴＭ７；２
９２−３１４（Ｐ）］ odorant receptor MOR83 [Mus musculus] (AB030894)；
174/304 (57%) 配列番号６６０［ＴＭ１；１−２３（Ｓ）、ＴＭ２；５
０−７２（Ｐ）、ＴＭ３；８１−１０３（Ｓ）、ＴＭ
４；１１３−１３５（Ｐ）、ＴＭ５；１６０−１８２
（Ｓ）、ＴＭ６；２２２−２４４（Ｐ）、ＴＭ７；２５
８−２８０（Ｓ）、ＴＭ８；２９２−３１４（Ｓ）］ olfactory receptor [Gorilla gorilla] (AF101764)；1
35/306 (44%)
（Ｓ）、ＴＭ２；８２−１０４（Ｓ）、ＴＭ３；１１３
−１３４（Ｓ）、ＴＭ４；１４４−１６６（Ｐ）、ＴＭ
５；１８１−２０３（Ｐ）、ＴＭ６；２１０−２３２
（Ｓ）］ HGMP07J [Homo sapiens] >gi|228481|prf||1804351C ol
factory receptor HGMP07J [Homo sapiens] (X64995)；
124/248 (50%) 配列番号６５４［ＴＭ１；１２−３４（Ｐ）、ＴＭ２；
４５−６７（Ｓ）、ＴＭ３；１０１−１２３（Ｓ）、Ｔ
Ｍ４；１４４−１６６（Ｓ）、ＴＭ５；１９７−２１９
（Ｐ）、ＴＭ６；２４０−２６１（Ｓ）、ＴＭ７；２７
２−２９３（Ｓ）］ HGMP07J [Homo sapiens] >gi|228481|prf||1804351C ol
factory receptor HGMP07J [Homo sapiens] (X64995)；
165/308 (53%) 配列番号６５６［ＴＭ１；２８−５０（Ｐ）、ＴＭ２；
９４−１１６（Ｓ）、ＴＭ３；１３９−１６１（Ｓ）、
ＴＭ４；２０３−２２５（Ｐ）、ＴＭ５；２３９−２６
０（Ｐ）、ＴＭ６；２７１−２９３（Ｓ）］ olfactory receptor P2 [Mus musculus] (AF247657)；1
55/308 (50%) 配列番号６５８［ＴＭ１；５１−７３（Ｐ）、ＴＭ２；
８３−１０５（Ｐ）、ＴＭ３；１５６−１７８（Ｐ）、
ＴＭ４；２０２−２２４（Ｐ）、ＴＭ５；２２９−２５
０（Ｐ）、ＴＭ６；２６５−２８７（Ｐ）、ＴＭ７；２
９２−３１４（Ｐ）］ odorant receptor MOR83 [Mus musculus] (AB030894)；
174/304 (57%) 配列番号６６０［ＴＭ１；１−２３（Ｓ）、ＴＭ２；５
０−７２（Ｐ）、ＴＭ３；８１−１０３（Ｓ）、ＴＭ
４；１１３−１３５（Ｐ）、ＴＭ５；１６０−１８２
（Ｓ）、ＴＭ６；２２２−２４４（Ｐ）、ＴＭ７；２５
８−２８０（Ｓ）、ＴＭ８；２９２−３１４（Ｓ）］ olfactory receptor [Gorilla gorilla] (AF101764)；1
35/306 (44%)
【０１０８】配列番号６６２［ＴＭ１；２３−４５
（Ｐ）、ＴＭ２；６０−８２（Ｓ）、ＴＭ３；９８−１
２０（Ｓ）、ＴＭ４；１３９−１６１（Ｐ）、ＴＭ５；
２０３−２２５（Ｐ）、ＴＭ６；２３７−２５９
（Ｓ）、ＴＭ７；２７１−２９２（Ｓ）］ olfactory receptor, family 12, subfamily D, member
2(NP_039224)；205/306(66%) 配列番号６６４［ＴＭ１；７−２９（Ｓ）、ＴＭ２；３
３−５５（Ｓ）、ＴＭ３；９５−１１７（Ｐ）、ＴＭ
４；１４１−１６３（Ｓ）、ＴＭ５；２０４−２２６
（Ｐ）、ＴＭ６；２４０−２６２（Ｐ）、ＴＭ７；２７
２−２９３（Ｓ）］ olfactory receptor [Mus musculus] (AJ251155)；157/
309 (50%) 配列番号６６６［ＴＭ１；１８−４０（Ｐ）、ＴＭ２；
５５−７７（Ｓ）、ＴＭ３；１１１−１３３（Ｐ）、Ｔ
Ｍ４；１４２−１６４（Ｐ）、ＴＭ５；１９５−２１７
（Ｐ）、ＴＭ６；２４６−２６８（Ｐ）、ＴＭ７；２８
４−３０５（Ｓ）］ candidate taste receptor T2R7(AF227133)；95/303 (3
1%) 配列番号６６８［ＴＭ１；８−３０（Ｐ）、ＴＭ２；４
５−６７（Ｓ）、ＴＭ３；９７−１１９（Ｓ）、ＴＭ
４；１２８−１５０（Ｐ）、ＴＭ５；１８０−２０２
（Ｐ）、ＴＭ６；２２８−２５０（Ｐ）、ＴＭ７；２５
２−２７３（Ｓ）、ＴＭ８；２７６−２９８（Ｓ）］ candidate taste receptor T2R13(AF227137)；140/307
(45%) 配列番号６７０［ＴＭ１；７−２９（Ｐ）、ＴＭ２；４
８−７０（Ｓ）、ＴＭ３；９９−１２０（Ｓ）、ＴＭ
４；１２９−１５１（Ｐ）、ＴＭ５；１７８−２００
（Ｐ）、ＴＭ６；２２７−２４９（Ｐ）］ candidate taste receptor T2R13(AF227137)；136/306
(44%)
（Ｐ）、ＴＭ２；６０−８２（Ｓ）、ＴＭ３；９８−１
２０（Ｓ）、ＴＭ４；１３９−１６１（Ｐ）、ＴＭ５；
２０３−２２５（Ｐ）、ＴＭ６；２３７−２５９
（Ｓ）、ＴＭ７；２７１−２９２（Ｓ）］ olfactory receptor, family 12, subfamily D, member
2(NP_039224)；205/306(66%) 配列番号６６４［ＴＭ１；７−２９（Ｓ）、ＴＭ２；３
３−５５（Ｓ）、ＴＭ３；９５−１１７（Ｐ）、ＴＭ
４；１４１−１６３（Ｓ）、ＴＭ５；２０４−２２６
（Ｐ）、ＴＭ６；２４０−２６２（Ｐ）、ＴＭ７；２７
２−２９３（Ｓ）］ olfactory receptor [Mus musculus] (AJ251155)；157/
309 (50%) 配列番号６６６［ＴＭ１；１８−４０（Ｐ）、ＴＭ２；
５５−７７（Ｓ）、ＴＭ３；１１１−１３３（Ｐ）、Ｔ
Ｍ４；１４２−１６４（Ｐ）、ＴＭ５；１９５−２１７
（Ｐ）、ＴＭ６；２４６−２６８（Ｐ）、ＴＭ７；２８
４−３０５（Ｓ）］ candidate taste receptor T2R7(AF227133)；95/303 (3
1%) 配列番号６６８［ＴＭ１；８−３０（Ｐ）、ＴＭ２；４
５−６７（Ｓ）、ＴＭ３；９７−１１９（Ｓ）、ＴＭ
４；１２８−１５０（Ｐ）、ＴＭ５；１８０−２０２
（Ｐ）、ＴＭ６；２２８−２５０（Ｐ）、ＴＭ７；２５
２−２７３（Ｓ）、ＴＭ８；２７６−２９８（Ｓ）］ candidate taste receptor T2R13(AF227137)；140/307
(45%) 配列番号６７０［ＴＭ１；７−２９（Ｐ）、ＴＭ２；４
８−７０（Ｓ）、ＴＭ３；９９−１２０（Ｓ）、ＴＭ
４；１２９−１５１（Ｐ）、ＴＭ５；１７８−２００
（Ｐ）、ＴＭ６；２２７−２４９（Ｐ）］ candidate taste receptor T2R13(AF227137)；136/306
(44%)
【０１０９】配列番号６７２［ＴＭ１；１０−３２
（Ｐ）、ＴＭ２；４２−６４（Ｐ）、ＴＭ３；９３−１
１５（Ｓ）、ＴＭ４；１２６−１４８（Ｐ）、ＴＭ５；
１８２−２０４（Ｐ）、ＴＭ６；２３５−２５７
（Ｐ）］ candidate taste receptor T2R7(AF227133)；131/311
(42%) 配列番号６７４［ＴＭ１；１９−４１（Ｓ）、ＴＭ２；
６１−８３（Ｓ）、ＴＭ３；１０８−１３０（Ｓ）、Ｔ
Ｍ４；１３８−１６０（Ｐ）、ＴＭ５；１９５−２１７
（Ｐ）、ＴＭ６；２４７−２６９（Ｐ）］ candidate taste receptor T2R9(AF227135)；101/307
(32%) 配列番号６７６［ＴＭ１；３４−５６（Ｐ）、ＴＭ２；
７５−９７（Ｓ）、ＴＭ３；１１４−１３６（Ｐ）、Ｔ
Ｍ４；１５８−１８０（Ｐ）、ＴＭ５；２０９−２３１
（Ｐ）、ＴＭ６；２６２−２８４（Ｐ）、ＴＭ７；２８
６−３０８（Ｓ）］ taste receptor rT2R6(AF240766)；100/291 (34%) 配列番号６７８［ＴＭ１；３４−５６（Ｐ）、ＴＭ２；
７５−９７（Ｓ）、ＴＭ３；１１４−１３６（Ｐ）、Ｔ
Ｍ４；１５８−１８０（Ｐ）、ＴＭ５；２０９−２３１
（Ｐ）、ＴＭ６；２５８−２８０（Ｐ）］ candidate taste receptor T2R7(AF227133)；103/310
(33%) 配列番号６８０［ＴＭ１；７−２９（Ｐ）、ＴＭ２；９
４−１１６（Ｐ）、ＴＭ３；１３１−１５３（Ｐ）、Ｔ
Ｍ４；１８２−２０４（Ｐ）、ＴＭ５；２３５−２５７
（Ｐ）、ＴＭ６；２６７−２８９（Ｐ）、ＴＭ７；２９
１−３０７（Ｓ）］ taste receptor rT2R12(AF240768)；214/307 (69%)
（Ｐ）、ＴＭ２；４２−６４（Ｐ）、ＴＭ３；９３−１
１５（Ｓ）、ＴＭ４；１２６−１４８（Ｐ）、ＴＭ５；
１８２−２０４（Ｐ）、ＴＭ６；２３５−２５７
（Ｐ）］ candidate taste receptor T2R7(AF227133)；131/311
(42%) 配列番号６７４［ＴＭ１；１９−４１（Ｓ）、ＴＭ２；
６１−８３（Ｓ）、ＴＭ３；１０８−１３０（Ｓ）、Ｔ
Ｍ４；１３８−１６０（Ｐ）、ＴＭ５；１９５−２１７
（Ｐ）、ＴＭ６；２４７−２６９（Ｐ）］ candidate taste receptor T2R9(AF227135)；101/307
(32%) 配列番号６７６［ＴＭ１；３４−５６（Ｐ）、ＴＭ２；
７５−９７（Ｓ）、ＴＭ３；１１４−１３６（Ｐ）、Ｔ
Ｍ４；１５８−１８０（Ｐ）、ＴＭ５；２０９−２３１
（Ｐ）、ＴＭ６；２６２−２８４（Ｐ）、ＴＭ７；２８
６−３０８（Ｓ）］ taste receptor rT2R6(AF240766)；100/291 (34%) 配列番号６７８［ＴＭ１；３４−５６（Ｐ）、ＴＭ２；
７５−９７（Ｓ）、ＴＭ３；１１４−１３６（Ｐ）、Ｔ
Ｍ４；１５８−１８０（Ｐ）、ＴＭ５；２０９−２３１
（Ｐ）、ＴＭ６；２５８−２８０（Ｐ）］ candidate taste receptor T2R7(AF227133)；103/310
(33%) 配列番号６８０［ＴＭ１；７−２９（Ｐ）、ＴＭ２；９
４−１１６（Ｐ）、ＴＭ３；１３１−１５３（Ｐ）、Ｔ
Ｍ４；１８２−２０４（Ｐ）、ＴＭ５；２３５−２５７
（Ｐ）、ＴＭ６；２６７−２８９（Ｐ）、ＴＭ７；２９
１−３０７（Ｓ）］ taste receptor rT2R12(AF240768)；214/307 (69%)
【０１１０】配列番号６８２［ＴＭ１；８−３０
（Ｐ）、ＴＭ２；４６−６８（Ｐ）、ＴＭ３；９１−１
１３（Ｓ）、ＴＭ４；１２８−１５０（Ｐ）、ＴＭ５；
１８０−２０２（Ｐ）、ＴＭ６；２２９−２５１
（Ｐ）］ candidate taste receptor T2R13(AF227137)；140/309
(45%) 配列番号６８４［ＴＭ１；８−３０（Ｐ）、ＴＭ２；４
５−６７（Ｐ）、ＴＭ３；９０−１１２（Ｐ）、ＴＭ
４；１２９−１５１（Ｐ）、ＴＭ５；１７８−２００
（Ｐ）、ＴＭ６；２２７−２４９（Ｐ）］ candidate taste receptor T2R13(AF227137)；116/246
(47%) 配列番号６８６［ＴＭ１；７−２９（Ｐ）、ＴＭ２；３
４−５６（Ｐ）、ＴＭ３；６１−８３（Ｐ）、ＴＭ４；
１１６−１３８（Ｐ）、ＴＭ５；１４７−１６９
（Ｐ）、ＴＭ６；１９７−２１９（Ｐ）、ＴＭ７；２４
８−２６９（Ｐ）、ＴＭ８；２９５−３１７（Ｓ）］ candidate taste receptor T2R13(AF227137)；131/292
(44%), 配列番号６８８［ＴＭ１；８−３０（Ｐ）、ＴＭ２；４
５−６７（Ｐ）、ＴＭ３；９７−１１９（Ｐ）、ＴＭ
４；１２６−１４８（Ｐ）、ＴＭ５；１７８−２００
（Ｐ）、ＴＭ６；２３０−２５１（Ｐ）、ＴＭ７；２６
７−２８９（Ｓ）］ candidate taste receptor T2R13(AF227137)；136/309
(44%) 配列番号６９０［ＴＭ１；８−３０（Ｐ）、ＴＭ２；４
５−６７（Ｐ）、ＴＭ３；９７−１１９（Ｐ）、ＴＭ
４；１２８−１５０（Ｐ）、ＴＭ５；１８０−２０２
（Ｐ）、ＴＭ６；２２９−２５１（Ｐ）］ candidate taste receptor T2R13(AF227137)；115/252
(45%)
（Ｐ）、ＴＭ２；４６−６８（Ｐ）、ＴＭ３；９１−１
１３（Ｓ）、ＴＭ４；１２８−１５０（Ｐ）、ＴＭ５；
１８０−２０２（Ｐ）、ＴＭ６；２２９−２５１
（Ｐ）］ candidate taste receptor T2R13(AF227137)；140/309
(45%) 配列番号６８４［ＴＭ１；８−３０（Ｐ）、ＴＭ２；４
５−６７（Ｐ）、ＴＭ３；９０−１１２（Ｐ）、ＴＭ
４；１２９−１５１（Ｐ）、ＴＭ５；１７８−２００
（Ｐ）、ＴＭ６；２２７−２４９（Ｐ）］ candidate taste receptor T2R13(AF227137)；116/246
(47%) 配列番号６８６［ＴＭ１；７−２９（Ｐ）、ＴＭ２；３
４−５６（Ｐ）、ＴＭ３；６１−８３（Ｐ）、ＴＭ４；
１１６−１３８（Ｐ）、ＴＭ５；１４７−１６９
（Ｐ）、ＴＭ６；１９７−２１９（Ｐ）、ＴＭ７；２４
８−２６９（Ｐ）、ＴＭ８；２９５−３１７（Ｓ）］ candidate taste receptor T2R13(AF227137)；131/292
(44%), 配列番号６８８［ＴＭ１；８−３０（Ｐ）、ＴＭ２；４
５−６７（Ｐ）、ＴＭ３；９７−１１９（Ｐ）、ＴＭ
４；１２６−１４８（Ｐ）、ＴＭ５；１７８−２００
（Ｐ）、ＴＭ６；２３０−２５１（Ｐ）、ＴＭ７；２６
７−２８９（Ｓ）］ candidate taste receptor T2R13(AF227137)；136/309
(44%) 配列番号６９０［ＴＭ１；８−３０（Ｐ）、ＴＭ２；４
５−６７（Ｐ）、ＴＭ３；９７−１１９（Ｐ）、ＴＭ
４；１２８−１５０（Ｐ）、ＴＭ５；１８０−２０２
（Ｐ）、ＴＭ６；２２９−２５１（Ｐ）］ candidate taste receptor T2R13(AF227137)；115/252
(45%)
【０１１１】配列番号６９２［ＴＭ１；８−３０
（Ｐ）、ＴＭ２；４６−６８（Ｓ）、ＴＭ３；９９−１
２１（Ｓ）、ＴＭ４；１２８−１５０（Ｐ）、ＴＭ５；
１８４−２０６（Ｐ）、ＴＭ６；２２９−２５１
（Ｐ）］ candidate taste receptor T2R13(AF227137)；136/306
(44%) 配列番号６９４［ＴＭ１；８−３０（Ｐ）、ＴＭ２；４
５−６７（Ｐ）、ＴＭ３；９７−１１９（Ｓ）、ＴＭ
４；１２８−１５０（Ｐ）、ＴＭ５；１７８−２００
（Ｐ）、ＴＭ６；２２８−２５０（Ｐ）、ＴＭ７；２７
６−２９８（Ｓ）］ candidate taste receptor T2R13(AF227137)；131/293
(44%)
（Ｐ）、ＴＭ２；４６−６８（Ｓ）、ＴＭ３；９９−１
２１（Ｓ）、ＴＭ４；１２８−１５０（Ｐ）、ＴＭ５；
１８４−２０６（Ｐ）、ＴＭ６；２２９−２５１
（Ｐ）］ candidate taste receptor T2R13(AF227137)；136/306
(44%) 配列番号６９４［ＴＭ１；８−３０（Ｐ）、ＴＭ２；４
５−６７（Ｐ）、ＴＭ３；９７−１１９（Ｓ）、ＴＭ
４；１２８−１５０（Ｐ）、ＴＭ５；１７８−２００
（Ｐ）、ＴＭ６；２２８−２５０（Ｐ）、ＴＭ７；２７
６−２９８（Ｓ）］ candidate taste receptor T2R13(AF227137)；131/293
(44%)
【０１１２】
【発明の効果】本発明によると、生体内情報伝達機構の
発見や新規薬物標的蛋白質の同定を可能とすることがで
きる新規ＧＰＣＲ遺伝子やＧＰＣＲ蛋白質をデータベー
ス上で網羅的に検索することができ、得られたＧＰＣＲ
蛋白質を用いることにより、その内在性リガンド等をス
クリーニングすることが可能となり、これらＧＰＣＲや
その内在性リガンドは、これらに作用する薬剤の研究
や、当該遺伝子及びその変異体の遺伝治療等への応用な
ど、新たな治療法への応用の可能性が期待される。また
味覚受容体及び嗅覚受容体のリガンドとして、新規味物
質、苦味阻害物質、新規匂い物質、匂い阻害物質の開発
などへの応用が期待される。さらに、新規ＧＰＣＲ遺伝
子の解析を通して新しい生体内情報伝達機構の発見や新
規薬物標的蛋白質の同定も期待できる。
発見や新規薬物標的蛋白質の同定を可能とすることがで
きる新規ＧＰＣＲ遺伝子やＧＰＣＲ蛋白質をデータベー
ス上で網羅的に検索することができ、得られたＧＰＣＲ
蛋白質を用いることにより、その内在性リガンド等をス
クリーニングすることが可能となり、これらＧＰＣＲや
その内在性リガンドは、これらに作用する薬剤の研究
や、当該遺伝子及びその変異体の遺伝治療等への応用な
ど、新たな治療法への応用の可能性が期待される。また
味覚受容体及び嗅覚受容体のリガンドとして、新規味物
質、苦味阻害物質、新規匂い物質、匂い阻害物質の開発
などへの応用が期待される。さらに、新規ＧＰＣＲ遺伝
子の解析を通して新しい生体内情報伝達機構の発見や新
規薬物標的蛋白質の同定も期待できる。
【０１１３】
【配列表】 SEQUENCE LISTING <110> JAPAN SCIENCE AND TECHNOLOGY CORPORATION <120> Novel G-protein coupled receptors <130> A011P33 <140> <141> <150> JP 2000/237818 <151> 2000-08-04 <160> 694 <170> PatentIn Ver. 2.1 <210> 1 <211> 972 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(972) <400> 1 atg tac aag gac tgc atc gag tcc act gga gac tat ttt ctt ctc tgt 48 Met Tyr Lys Asp Cys Ile Glu Ser Thr Gly Asp Tyr Phe Leu Leu Cys 1 5 10 15 gac gcc gag ggg cca tgg ggc atc att ctg gag tcc ctg gcc ata ctt 96 Asp Ala Glu Gly Pro Trp Gly Ile Ile Leu Glu Ser Leu Ala Ile Leu 20 25 30 ggc atc gtg gtc aca att ctg cta ctc tta gca ttt ctc ttc ctc atg 144 Gly Ile Val Val Thr Ile Leu Leu Leu Leu Ala Phe Leu Phe Leu Met 35 40 45 cga aag atc caa gac tgc agc cag tgg aat gtc ctc ccc acc cag ctc 192 Arg Lys Ile Gln Asp Cys Ser Gln Trp Asn Val Leu Pro Thr Gln Leu 50 55 60 ctc ttc ctc ctg agt gtc ctg ggg ctc ttc gga ctc gct ttt gcc ttc 240 Leu Phe Leu Leu Ser Val Leu Gly Leu Phe Gly Leu Ala Phe Ala Phe 65 70 75 80 atc atc gag ctc aat caa caa act gcc ccc gta cgc tac ttt ctc ttt 288 Ile Ile Glu Leu Asn Gln Gln Thr Ala Pro Val Arg Tyr Phe Leu Phe 85 90 95 ggg gtt ctc ttt gct ctc tgt ttc tca tgc ctc tta gct cat gcc tcc 336 Gly Val Leu Phe Ala Leu Cys Phe Ser Cys Leu Leu Ala His Ala Ser 100 105 110 aat cta gtg aag ctg gtt cgg ggt tgt gtc tcc ttc tcc tgg acg aca 384 Asn Leu Val Lys Leu Val Arg Gly Cys Val Ser Phe Ser Trp Thr Thr 115 120 125 att ctg tgc att gct att ggt tgc agt ctg ttg caa atc att att gcc 432 Ile Leu Cys Ile Ala Ile Gly Cys Ser Leu Leu Gln Ile Ile Ile Ala 130 135 140 act gag tat gtg act ctc atc atg acc aga ggt atg atg ttt gtg aat 480 Thr Glu Tyr Val Thr Leu Ile Met Thr Arg Gly Met Met Phe Val Asn 145 150 155 160 atg aca ccc tgc cag ctc aat gtg gac ttt gtt gta ctc ctg gtc tat 528 Met Thr Pro Cys Gln Leu Asn Val Asp Phe Val Val Leu Leu Val Tyr 165 170 175 gtc ctc ttc ctg atg gcc ctc aca ttc ttc gtc tcc aaa gcc acc ttc 576 Val Leu Phe Leu Met Ala Leu Thr Phe Phe Val Ser Lys Ala Thr Phe 180 185 190 tgt ggc ccg tgt gag aac tgg aag cag cat gga agg ctc atc ttt atc 624 Cys Gly Pro Cys Glu Asn Trp Lys Gln His Gly Arg Leu Ile Phe Ile 195 200 205 act gtg ctc ttc tcc atc atc atc tgg gtg gtg tgg atc tcc atg ctc 672 Thr Val Leu Phe Ser Ile Ile Ile Trp Val Val Trp Ile Ser Met Leu 210 215 220 ctg aga ggc aac ccg cag ttc cag cga cag ccc cag tgg gac gac ccg 720 Leu Arg Gly Asn Pro Gln Phe Gln Arg Gln Pro Gln Trp Asp Asp Pro 225 230 235 240 gtc gtc tgc att gct ctg gtc acc aac gca tgg gtt ttc ctg ctg ctg 768 Val Val Cys Ile Ala Leu Val Thr Asn Ala Trp Val Phe Leu Leu Leu 245 250 255 tac atc gtc cct gag ctc tgc att ctc tac aga tcg tgt aga cag gag 816 Tyr Ile Val Pro Glu Leu Cys Ile Leu Tyr Arg Ser Cys Arg Gln Glu 260 265 270 tgc cct tta caa ggc aat gcc tgc ccc gtc aca gcc tac caa cac agc 864 Cys Pro Leu Gln Gly Asn Ala Cys Pro Val Thr Ala Tyr Gln His Ser 275 280 285 ttc caa gtg gag aac cag gag ctc tcc aga ggt aca ttc ctg ggg gat 912 Phe Gln Val Glu Asn Gln Glu Leu Ser Arg Gly Thr Phe Leu Gly Asp 290 295 300 tca ggg agc agg gag gtg ctc cta cag gag aag cag gag aaa aat cat 960 Ser Gly Ser Arg Glu Val Leu Leu Gln Glu Lys Gln Glu Lys Asn His 305 310 315 320 gca gta gga tga 972 Ala Val Gly <210> 2 <211> 323 <212> PRT <213> Homo sapiens <400> 2 Met Tyr Lys Asp Cys Ile Glu Ser Thr Gly Asp Tyr Phe Leu Leu Cys 1 5 10 15 Asp Ala Glu Gly Pro Trp Gly Ile Ile Leu Glu Ser Leu Ala Ile Leu 20 25 30 Gly Ile Val Val Thr Ile Leu Leu Leu Leu Ala Phe Leu Phe Leu Met 35 40 45 Arg Lys Ile Gln Asp Cys Ser Gln Trp Asn Val Leu Pro Thr Gln Leu 50 55 60 Leu Phe Leu Leu Ser Val Leu Gly Leu Phe Gly Leu Ala Phe Ala Phe 65 70 75 80 Ile Ile Glu Leu Asn Gln Gln Thr Ala Pro Val Arg Tyr Phe Leu Phe 85 90 95 Gly Val Leu Phe Ala Leu Cys Phe Ser Cys Leu Leu Ala His Ala Ser 100 105 110 Asn Leu Val Lys Leu Val Arg Gly Cys Val Ser Phe Ser Trp Thr Thr 115 120 125 Ile Leu Cys Ile Ala Ile Gly Cys Ser Leu Leu Gln Ile Ile Ile Ala 130 135 140 Thr Glu Tyr Val Thr Leu Ile Met Thr Arg Gly Met Met Phe Val Asn 145 150 155 160 Met Thr Pro Cys Gln Leu Asn Val Asp Phe Val Val Leu Leu Val Tyr 165 170 175 Val Leu Phe Leu Met Ala Leu Thr Phe Phe Val Ser Lys Ala Thr Phe 180 185 190 Cys Gly Pro Cys Glu Asn Trp Lys Gln His Gly Arg Leu Ile Phe Ile 195 200 205 Thr Val Leu Phe Ser Ile Ile Ile Trp Val Val Trp Ile Ser Met Leu 210 215 220 Leu Arg Gly Asn Pro Gln Phe Gln Arg Gln Pro Gln Trp Asp Asp Pro 225 230 235 240 Val Val Cys Ile Ala Leu Val Thr Asn Ala Trp Val Phe Leu Leu Leu 245 250 255 Tyr Ile Val Pro Glu Leu Cys Ile Leu Tyr Arg Ser Cys Arg Gln Glu 260 265 270 Cys Pro Leu Gln Gly Asn Ala Cys Pro Val Thr Ala Tyr Gln His Ser 275 280 285 Phe Gln Val Glu Asn Gln Glu Leu Ser Arg Gly Thr Phe Leu Gly Asp 290 295 300 Ser Gly Ser Arg Glu Val Leu Leu Gln Glu Lys Gln Glu Lys Asn His 305 310 315 320 Ala Val Gly <210> 3 <211> 1107 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1107) <400> 3 atg ccc cgc ctt ggc act tca gcc aca aca aac ccc cca cgg cac aat 48 Met Pro Arg Leu Gly Thr Ser Ala Thr Thr Asn Pro Pro Arg His Asn 1 5 10 15 ggt gca tat gcc ctg agg ctt gga att ggg ttg ctt tta tgt aca agg 96 Gly Ala Tyr Ala Leu Arg Leu Gly Ile Gly Leu Leu Leu Cys Thr Arg 20 25 30 cta gct ggg ctt ttt cat cgt tgc cct gaa gag aca cct gtt tgc cac 144 Leu Ala Gly Leu Phe His Arg Cys Pro Glu Glu Thr Pro Val Cys His 35 40 45 tcc tct ccc tgg ctg agt cct ctg gca tcc atg gtg ggt ggt cga gcc 192 Ser Ser Pro Trp Leu Ser Pro Leu Ala Ser Met Val Gly Gly Arg Ala 50 55 60 aag aat ttg tgg tat gga gct tgt gtg gcg gcg ctg gtg gcc ctg tta 240 Lys Asn Leu Trp Tyr Gly Ala Cys Val Ala Ala Leu Val Ala Leu Leu 65 70 75 80 gct gcc gtg cgc ttg tgg ctt cgc cgc tat ggt aat ctc aag agc ccc 288 Ala Ala Val Arg Leu Trp Leu Arg Arg Tyr Gly Asn Leu Lys Ser Pro 85 90 95 gag cca ccc atg ctc ttt gtg cgc tgg gga ctg ccc cta atg gca ttg 336 Glu Pro Pro Met Leu Phe Val Arg Trp Gly Leu Pro Leu Met Ala Leu 100 105 110 ggt act gct gcc tac tgg gca ttg gcg tcg ggg gca gat gag gct ccc 384 Gly Thr Ala Ala Tyr Trp Ala Leu Ala Ser Gly Ala Asp Glu Ala Pro 115 120 125 ccc cgt ctc cgg gtc ctg gtc tct ggg gca tcc atg gtg ctg cct cgg 432 Pro Arg Leu Arg Val Leu Val Ser Gly Ala Ser Met Val Leu Pro Arg 130 135 140 gc t gta gca ggg ctg gct gct tca ggg ctc gcg ctg ctg ctc tgg aag 480 Ala Val Ala Gly Leu Ala Ala Ser Gly Leu Ala Leu Leu Leu Trp Lys 145 150 155 160 cct gtg aca gtg ctg gtg aag gct ggg gca ggc gct cca agg acc agg 528 Pro Val Thr Val Leu Val Lys Ala Gly Ala Gly Ala Pro Arg Thr Arg 165 170 175 act gtc ctc act ccc ttc tca ggc ccc ccc act tct caa gct gac ttg 576 Thr Val Leu Thr Pro Phe Ser Gly Pro Pro Thr Ser Gln Ala Asp Leu 180 185 190 gat tat gtg gtc cct caa atc tac cga cac atg cag gag gag ttc cgg 624 Asp Tyr Val Val Pro Gln Ile Tyr Arg His Met Gln Glu Glu Phe Arg 195 200 205 ggc cgg tta gag agg acc aaa tct cag ggt ccc ctg act gtg gct gct 672 Gly Arg Leu Glu Arg Thr Lys Ser Gln Gly Pro Leu Thr Val Ala Ala 210 215 220 tat cag ttg ggg agt gtc tac tca gct gct atg gtc aca gcc ctc acc 720 Tyr Gln Leu Gly Ser Val Tyr Ser Ala Ala Met Val Thr Ala Leu Thr 225 230 235 240 ctg ttg gcc ttc cca ctt ctg ctg ttg cat gcg gag cgc atc agc ctt 768 Leu Leu Ala Phe Pro Leu Leu Leu Leu His Ala Glu Arg Ile Ser Leu 245 250 255 gtg ttc ctg ctt ctg ttt ctg cag agc ttc ctt ctc cta cat ctg ctt 816 Val Phe Leu Leu Leu Phe Leu Gln Ser Phe Leu Leu Leu His Leu Leu 260 265 270 gct gct ggg ata ccc gtc acc acc cct ggt aaa tat ctc agc tct gat 864 Ala Ala Gly Ile Pro Val Thr Thr Pro Gly Lys Tyr Leu Ser Ser Asp 275 280 285 tca ctt aaa gac aat agt gat gtg agt tcg gcc cct ctt gtt ttc aag 912 Ser Leu Lys Asp Asn Ser Asp Val Ser Ser Ala Pro Leu Val Phe Lys 290 295 300 gag gtg ttg ctc ctc atg ttc ctg agc ttg aca gag ggt ccc atg ccc 960 Glu Val Leu Leu Leu Met Phe Leu Ser Leu Thr Glu Gly Pro Met Pro 305 310 315 320 cac aca act agg aag gtc ttc ttg gtg tcc tct ctc tta cct gcc ata 1008 His Thr Thr Arg Lys Val Phe Leu Val Ser Ser Leu Leu Pro Ala Ile 325 330 335 gcc aag caa att gat ccc tcc tgt tgg ttc cca ggg ttc atg gag agg 1056 Ala Lys Gln Ile Asp Pro Ser Cys Trp Phe Pro Gly Phe Met Glu Arg 340 345 350 aga gac aag gag tcc tct aag act ccc tgt gga aat gct gca tcc tca 1104 Arg Asp Lys Glu Ser Ser Lys Thr Pro Cys Gly Asn Ala Ala Ser Ser 355 360 365 tga 1107 <210> 4 <211> 368 <212> PRT <213> Homo sapiens <400> 4 Met Pro Arg Leu Gly Thr Ser Ala Thr Thr Asn Pro Pro Arg His Asn 1 5 10 15 Gly Ala Tyr Ala Leu Arg Leu Gly Ile Gly Leu Leu Leu Cys Thr Arg 20 25 30 Leu Ala Gly Leu Phe His Arg Cys Pro Glu Glu Thr Pro Val Cys His 35 40 45 Ser Ser Pro Trp Leu Ser Pro Leu Ala Ser Met Val Gly Gly Arg Ala 50 55 60 Lys Asn Leu Trp Tyr Gly Ala Cys Val Ala Ala Leu Val Ala Leu Leu 65 70 75 80 Ala Ala Val Arg Leu Trp Leu Arg Arg Tyr Gly Asn Leu Lys Ser Pro 85 90 95 Glu Pro Pro Met Leu Phe Val Arg Trp Gly Leu Pro Leu Met Ala Leu 100 105 110 Gly Thr Ala Ala Tyr Trp Ala Leu Ala Ser Gly Ala Asp Glu Ala Pro 115 120 125 Pro Arg Leu Arg Val Leu Val Ser Gly Ala Ser Met Val Leu Pro Arg 130 135 140 Ala Val Ala Gly Leu Ala Ala Ser Gly Leu Ala Leu Leu Leu Trp Lys 145 150 155 160 Pro Val Thr Val Leu Val Lys Ala Gly Ala Gly Ala Pro Arg Thr Arg 165 170 175 Thr Val Leu Thr Pro Phe Ser Gly Pro Pro Thr Ser Gln Ala Asp Leu 180 185 190 Asp Tyr Val Val Pro Gln Ile Tyr Arg His Met Gln Glu Glu Phe Arg 195 200 205 Gly Arg Leu Glu Arg Thr Lys Ser Gln Gly Pro Leu Thr Val Ala Ala 210 215 220 Tyr Gln Leu Gly Ser Val Tyr Ser Ala Ala Met Val Thr Ala Leu Thr 225 230 235 240 Leu Leu Ala Phe Pro Leu Leu Leu Leu His Ala Glu Arg Ile Ser Leu 245 250 255 Val Phe Leu Leu Leu Phe Leu Gln Ser Phe Leu Leu Leu His Leu Leu 260 265 270 Ala Ala Gly Ile Pro Val Thr Thr Pro Gly Lys Tyr Leu Ser Ser Asp 275 280 285 Ser Leu Lys Asp Asn Ser Asp Val Ser Ser Ala Pro Leu Val Phe Lys 290 295 300 Glu Val Leu Leu Leu Met Phe Leu Ser Leu Thr Glu Gly Pro Met Pro 305 310 315 320 His Thr Thr Arg Lys Val Phe Leu Val Ser Ser Leu Leu Pro Ala Ile 325 330 335 Ala Lys Gln Ile Asp Pro Ser Cys Trp Phe Pro Gly Phe Met Glu Arg 340 345 350 Arg Asp Lys Glu Ser Ser Lys Thr Pro Cys Gly Asn Ala Ala Ser Ser 355 360 365 <210> 5 <211> 1272 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1272) <400> 5 atg ttg tgt cac cgt ggt ggc cag ctg ata gtg cca atc atc cca ctt 48 Met Leu Cys His Arg Gly Gly Gln Leu Ile Val Pro Ile Ile Pro Leu 1 5 10 15 tgc cct gag cac tcc tgc agg ggt aga aga ctc cag aac ctt ctc tca 96 Cys Pro Glu His Ser Cys Arg Gly Arg Arg Leu Gln Asn Leu Leu Ser 20 25 30 ggc cca tgg ccc aag cag ccc atg gaa ctt cat aac ctg agc tct cca 144 Gly Pro Trp Pro Lys Gln Pro Met Glu Leu His Asn Leu Ser Ser Pro 35 40 45 tct ccc tct ctc tcc tcc tct gtt ctc cct ccc tcc ttc tct ccc tca 192 Ser Pro Ser Leu Ser Ser Ser Val Leu Pro Pro Ser Phe Ser Pro Ser 50 55 60 ccc tcc tct gct ccc tct gcc ttt acc act gtg ggg ggg tcc tct gga 240 Pro Ser Ser Ala Pro Ser Ala Phe Thr Thr Val Gly Gly Ser Ser Gly 65 70 75 80 ggg ccc tgc cac ccc acc tct tcc tcg ctg gtg tct gcc ttc ctg gca 288 Gly Pro Cys His Pro Thr Ser Ser Ser Leu Val Ser Ala Phe Leu Ala 85 90 95 cca atc ctg gcc ctg gag ttt gtc ctg ggc ctg gtg ggg aac agt ttg 336 Pro Ile Leu Ala Leu Glu Phe Val Leu Gly Leu Val Gly Asn Ser Leu 100 105 110 gcc ctc ttc atc ttc tgc atc cac acg cgg ccc tgg acc tcc aac acg 384 Ala Leu Phe Ile Phe Cys Ile His Thr Arg Pro Trp Thr Ser Asn Thr 115 120 125 gtg ttc ctg gtc agc ctg gtg gcc gct gac ttc ctc ctg atc agc aac 432 Val Phe Leu Val Ser Leu Val Ala Ala Asp Phe Leu Leu Ile Ser Asn 130 135 140 ctg ccc ctc cgc gtg gac tac tac ctc ctc cat gag acc tgg cgc ttt 480 Leu Pro Leu Arg Val Asp Tyr Tyr Leu Leu His Glu Thr Trp Arg Phe 145 150 155 160 ggg gct gct gcc tgc aaa gtc aac ctc ttc atg ctg tcc acc aac cgc 528 Gly Ala Ala Ala Cys Lys Val Asn Leu Phe Met Leu Ser Thr Asn Arg 165 170 175 acg gcc agc gtt gtc ttc ctc aca gcc atc gca ctc aac cgc tac ctg 576 Thr Ala Ser Val Val Phe Leu Thr Ala Ile Ala Leu Asn Arg Tyr Leu 180 185 190 aag gtg gtg cag ccc cac cac gtg ctg agc cgt gct tcc gtg ggg gca 624 Lys Val Val Gln Pro His His Val Leu Ser Arg Ala Ser Val Gly Ala 195 200 205 gct gcc cgg gtg gcc ggg gga ctc tgg gtg ggc atc ctg ctc ctc aac 672 Ala Ala Arg Val Ala Gly Gly Leu Trp Val Gly Ile Leu Leu Leu Asn 210 215 220 ggg cac ctg ctc ctg agc acc ttc tcc ggc ccc tcc tgc ctc agc tac 720 Gly His Leu Leu Leu Ser Thr Phe Ser Gly Pro Ser Cys Leu Ser Tyr 225 230 235 240 agg gtg ggc acg aag ccc tcg gcc tcg ctc cgc tgg cac cag gca ctg 768 Arg Val Gly Thr Lys Pro Ser Ala Ser Leu Arg Trp His Gln Ala Leu 245 250 255 tac ctg ctg gag ttc ttc ctg cca ctg gcg ctc atc ctc ttt gct att 816 Tyr Leu Leu Glu Phe Phe Leu Pro Leu Ala Leu Ile Leu Phe Ala Ile 260 265 270 gtg agc att ggg ctc acc atc cgg aac cgt ggt ctg ggc ggg cag gca 864 Val Ser Ile Gly Leu Thr Ile Arg Asn Arg Gly Leu Gly Gly Gln Ala 275 280 285 ggc ccg cag agg gcc atg cgt gtg ctg gcc atg gtg gtg gcc gtc tac 912 Gly Pro Gln Arg Ala Met Arg Val Leu Ala Met Val Val Ala Val Tyr 290 295 300 acc atc tgc ttc ttg ccc agc atc atc ttt ggc atg gct tcc atg gtg 960 Thr Ile Cys Phe Leu Pro Ser Ile Ile Phe Gly Met Ala Ser Met Val 305 310 315 320 gct ttc tgg ctg tcc gcc tgc cga tcc ctg gac ctc tgc aca cag ctc 1008 Ala Phe Trp Leu Ser Ala Cys Arg Ser Leu Asp Leu Cys Thr Gln Leu 325 330 335 ttc cat ggc tcc ctg gcc ttc acc tac ctc aac agt gtc ctg gac ccc 1056 Phe His Gly Ser Leu Ala Phe Thr Tyr Leu Asn Ser Val Leu Asp Pro 340 345 350 gtg ctc tac tgc ttc tct agc ccc aac ttc ctc cac cag agc cgg gcc 1104 Val Leu Tyr Cys Phe Ser Ser Pro Asn Phe Leu His Gln Ser Arg Ala 355 360 365 ttg ctg ggc ctc acg cgg ggc cgg cag ggc cca gtg agc gac gag agc 1152 Leu Leu Gly Leu Thr Arg Gly Arg Gln Gly Pro Val Ser Asp Glu Ser 370 375 380 tcc tac caa ccc tcc agg cag tgg cgc tac cgg gag gcc tct agg aag 1200 Ser Tyr Gln Pro Ser Arg Gln Trp Arg Tyr Arg Glu Ala Ser Arg Lys 385 390 395 400 gcg gag gcc ata ggg aag ctg aaa gtg cag ggc gag gtc tct ctg gaa 1248 Ala Glu Ala Ile Gly Lys Leu Lys Val Gln Gly Glu Val Ser Leu Glu 405 410 415 aag gaa ggc tcc tcc cag ggc tga 1272 Lys Glu Gly Ser Ser Gln Gly 420 <210> 6 <211> 423 <2 12> PRT <213> Homo sapiens <400> 6 Met Leu Cys His Arg Gly Gly Gln Leu Ile Val Pro Ile Ile Pro Leu 1 5 10 15 Cys Pro Glu His Ser Cys Arg Gly Arg Arg Leu Gln Asn Leu Leu Ser 20 25 30 Gly Pro Trp Pro Lys Gln Pro Met Glu Leu His Asn Leu Ser Ser Pro 35 40 45 Ser Pro Ser Leu Ser Ser Ser Val Leu Pro Pro Ser Phe Ser Pro Ser 50 55 60 Pro Ser Ser Ala Pro Ser Ala Phe Thr Thr Val Gly Gly Ser Ser Gly 65 70 75 80 Gly Pro Cys His Pro Thr Ser Ser Ser Leu Val Ser Ala Phe Leu Ala 85 90 95 Pro Ile Leu Ala Leu Glu Phe Val Leu Gly Leu Val Gly Asn Ser Leu 100 105 110 Ala Leu Phe Ile Phe Cys Ile His Thr Arg Pro Trp Thr Ser Asn Thr 115 120 125 Val Phe Leu Val Ser Leu Val Ala Ala Asp Phe Leu Leu Ile Ser Asn 130 135 140 Leu Pro Leu Arg Val Asp Tyr Tyr Leu Leu His Glu Thr Trp Arg Phe 145 150 155 160 Gly Ala Ala Ala Cys Lys Val Asn Leu Phe Met Leu Ser Thr Asn Arg 165 170 175 Thr Ala Ser Val Val Phe Leu Thr Ala Ile Ala Leu Asn Arg Tyr Leu 180 185 190 Lys Val Val Gln Pro His His Val Leu Ser Arg Ala Ser Val Gly Ala 195 200 205 Ala Ala Arg Val Ala Gly Gly Leu Trp Val Gly Ile Leu Leu Leu Asn 210 215 220 Gly His Leu Leu Leu Ser Thr Phe Ser Gly Pro Ser Cys Leu Ser Tyr 225 230 235 240 Arg Val Gly Thr Lys Pro Ser Ala Ser Leu Arg Trp His Gln Ala Leu 245 250 255 Tyr Leu Leu Glu Phe Phe Leu Pro Leu Ala Leu Ile Leu Phe Ala Ile 260 265 270 Val Ser Ile Gly Leu Thr Ile Arg Asn Arg Gly Leu Gly Gly Gln Ala 275 280 285 Gly Pro Gln Arg Ala Met Arg Val Leu Ala Met Val Val Ala Val Tyr 290 295 300 Thr Ile Cys Phe Leu Pro Ser Ile Ile Phe Gly Met Ala Ser Met Val 305 310 315 320 Ala Phe Trp Leu Ser Ala Cys Arg Ser Leu Asp Leu Cys Thr Gln Leu 325 330 335 Phe His Gly Ser Leu Ala Phe Thr Tyr Leu Asn Ser Val Leu Asp Pro 340 345 350 Val Leu Tyr Cys Phe Ser Ser Pro Asn Phe Leu His Gln Ser Arg Ala 355 360 365 Leu Leu Gly Leu Thr Arg Gly Arg Gln Gly Pro Val Ser Asp Glu Ser 370 375 380 Ser Tyr Gln Pro Ser Arg Gln Trp Arg Tyr Arg Glu Ala Ser Arg Lys 385 390 395 400 Ala Glu Ala Ile Gly Lys Leu Lys Val Gln Gly Glu Val Ser Leu Glu 405 410 415 Lys Glu Gly Ser Ser Gln Gly 420 <210> 7 <211> 1041 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1041) <400> 7 atg tac aac ggg tcg tgc tgc cgc atc gag ggg gac acc atc tcc cag 48 Met Tyr Asn Gly Ser Cys Cys Arg Ile Glu Gly Asp Thr Ile Ser Gln 1 5 10 15 gtg atg ccg ccg ctg ctc att gtg gcc ttt gtg ctg ggc gca cta ggc 96 Val Met Pro Pro Leu Leu Ile Val Ala Phe Val Leu Gly Ala Leu Gly 20 25 30 aat ggg gtc gcc ctg tgt ggt ttc tgc ttc cac atg aag acc tgg aag 144 Asn Gly Val Ala Leu Cys Gly Phe Cys Phe His Met Lys Thr Trp Lys 35 40 45 ccc agc act gtt tac ctt ttc aat ttg gcc gtg gct gat ttc ctc ctt 192 Pro Ser Thr Val Tyr Leu Phe Asn Leu Ala Val Ala Asp Phe Leu Leu 50 55 60 atg atc tgc ctg cct ttt cgg aca gac tat tac ctc aga cgt aga cac 240 Met Ile Cys Leu Pro Phe Arg Thr Asp Tyr Tyr Leu Arg Arg Arg His 65 70 75 80 tgg gct ttt ggg gac att ccc tgc cga gtg ggg ctc ttc acg ttg gcc 288 Trp Ala Phe Gly Asp Ile Pro Cys Arg Val Gly Leu Phe Thr Leu Ala 85 90 95 atg aac agg gcc ggg agc atc gtg ttc ctt acg gtg gtg gct gcg gac 336 Met Asn Arg Ala Gly Ser Ile Val Phe Leu Thr Val Val Ala Ala Asp 100 105 110 agg tat ttc aaa gtg gtc cac ccc cac cac gcg gtg aac act atc tcc 384 Arg Tyr Phe Lys Val Val His Pro His His Ala Val Asn Thr Ile Ser 115 120 125 acc cgg gtg gcg gct ggc atc gtc tgc acc ctg tgg gcc ctg gtc atc 432 Thr Arg Val Ala Ala Gly Ile Val Cys Thr Leu Trp Ala Leu Val Ile 130 135 140 ctg gga aca gtg tat ctt ttg ctg gag aac cat ctc tgc gtg caa gag 480 Leu Gly Thr Val Tyr Leu Leu Leu Glu Asn His Leu Cys Val Gln Glu 145 150 155 160 acg gcc gtc tcc tgt gag agc ttc atc atg gag tcg gcc aat ggc tgg 528 Thr Ala Val Ser Cys Glu Ser Phe Ile Met Glu Ser Ala Asn Gly Trp 165 170 175 cat gac atc atg ttc cag ctg gag ttc ttt atg ccc ctc ggc atc atc 576 His Asp Ile Met Phe Gln Leu Glu Phe Phe Met Pro Leu Gly Ile Ile 180 185 190 tta ttt tgc tcc ttc aag att gtt tgg agc ctg agg cgg agg cag cag 624 Leu Phe Cys Ser Phe Lys Ile Val Trp Ser Leu Arg Arg Arg Gln Gln 195 200 205 ctg gcc aga cag gct cgg atg aag aag gcg acc cgg ttc atc atg gtg 672 Leu Ala Arg Gln Ala Arg Met Lys Lys Ala Thr Arg Phe Ile Met Val 210 215 220 gtg gca att gtg ttc atc aca tgc tac ctg ccc agc gtg tct gct aga 720 Val Ala Ile Val Phe Ile Thr Cys Tyr Leu Pro Ser Val Ser Ala Arg 225 230 235 240 ctc tat ttc ctc tgg acg gtg ccc tcg agt gcc tgc gat ccc tct gtc 768 Leu Tyr Phe Leu Trp Thr Val Pro Ser Ser Ala Cys Asp Pro Ser Val 245 250 255 cat ggg gcc ctg cac ata acc ctc agc ttc acc tac atg aac agc atg 816 His Gly Ala Leu His Ile Thr Leu Ser Phe Thr Tyr Met Asn Ser Met 260 265 270 ctg gat ccc ctg gtg tat tat ttt tca agc ccc tcc ttt ccc aaa ttc 864 Leu Asp Pro Leu Val Tyr Tyr Phe Ser Ser Pro Ser Phe Pro Lys Phe 275 280 285 tac aac aag ctc aaa atc tgc agt ctg aaa ccc aag cag cca gga cac 912 Tyr Asn Lys Leu Lys Ile Cys Ser Leu Lys Pro Lys Gln Pro Gly His 290 295 300 tca aaa aca caa agg ccg gaa gag atg cca att tcg aac ctc ggt cgc 960 Ser Lys Thr Gln Arg Pro Glu Glu Met Pro Ile Ser Asn Leu Gly Arg 305 310 315 320 agg agt tgc atc agt gtg gca aat agt ttc caa agc cag tct gat ggg 1008 Arg Ser Cys Ile Ser Val Ala Asn Ser Phe Gln Ser Gln Ser Asp Gly 325 330 335 caa tgg gat ccc cac att gtt gag tgg cac tga 1041 Gln Trp Asp Pro His Ile Val Glu Trp His 340 345 <210> 8 <211> 346 <212> PRT <213> Homo sapiens <400> 8 Met Tyr Asn Gly Ser Cys Cys Arg Ile Glu Gly Asp Thr Ile Ser Gln 1 5 10 15 Val Met Pro Pro Leu Leu Ile Val Ala Phe Val Leu Gly Ala Leu Gly 20 25 30 Asn Gly Val Ala Leu Cys Gly Phe Cys Phe His Met Lys Thr Trp Lys 35 40 45 Pro Ser Thr Val Tyr Leu Phe Asn Leu Ala Val Ala Asp Phe Leu Leu 50 55 60 Met Ile Cys Leu Pro Phe Arg Thr Asp Tyr Tyr Leu Arg Arg Arg His 65 70 75 80 Trp Ala Phe Gly Asp Ile Pro Cys Arg Val Gly Leu Phe Thr Leu Ala 85 90 95 Met Asn Arg Ala Gly Ser Ile Val Phe Leu Thr Val Val Ala Ala Asp 100 105 110 Arg Tyr Phe Lys Val Val His Pro His His Ala Val Asn Thr Ile Ser 115 120 125 Thr Arg Val Ala Ala Gly Ile Val Cys Thr Leu Trp Ala Leu Val Ile 130 135 140 Leu Gly Thr Val Tyr Leu Leu Leu Glu Asn His Leu Cys Val Gln Glu 145 150 155 160 Thr Ala Val Ser Cys Glu Ser Phe Ile Met Glu Ser Ala Asn Gly Trp 165 170 175 His Asp Ile Met Phe Gln Leu Glu Phe Phe Met Pro Leu Gly Ile Ile 180 185 190 Leu Phe Cys Ser Phe Lys Ile Val Trp Ser Leu Arg Arg Arg Gln Gln 195 200 205 Leu Ala Arg Gln Ala Arg Met Lys Lys Ala Thr Arg Phe Ile Met Val 210 215 220 Val Ala Ile Val Phe Ile Thr Cys Tyr Leu Pro Ser Val Ser Ala Arg 225 230 235 240 Leu Tyr Phe Leu Trp Thr Val Pro Ser Ser Ala Cys Asp Pro Ser Val 245 250 255 His Gly Ala Leu His Ile Thr Leu Ser Phe Thr Tyr Met Asn Ser Met 260 265 270 Leu Asp Pro Leu Val Tyr Tyr Phe Ser Ser Pro Ser Phe Pro Lys Phe 275 280 285 Tyr Asn Lys Leu Lys Ile Cys Ser Leu Lys Pro Lys Gln Pro Gly His 290 295 300 Ser Lys Thr Gln Arg Pro Glu Glu Met Pro Ile Ser Asn Leu Gly Arg 305 310 315 320 Arg Ser Cys Ile Ser Val Ala Asn Ser Phe Gln Ser Gln Ser Asp Gly 325 330 335 Gln Trp Asp Pro His Ile Val Glu Trp His 340 345 <210> 9 <211> 1413 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1413) <400> 9 atg gac act acc atg gaa gct gac ctg ggt gcc act ggc cac agg ccc 48 Met Asp Thr Thr Met Glu Ala Asp Leu Gly Ala Thr Gly His Arg Pro 1 5 10 15 cgc aca gag ctt gat gat gag gac tcc tac ccc caa ggt ggc tgg gac 96 Arg Thr Glu Leu Asp Asp Glu Asp Ser Tyr Pro Gln Gly Gly Trp Asp 20 25 30 acg gtc ttc ctg gtg gcc ctg ctg ctc ctt ggg ctg cca gcc aat ggg 144 Thr Val Phe Leu Val Ala Leu Leu Leu Leu Gly Leu Pro Ala Asn Gly 35 40 45 ttg atg gcg tgg ctg gcc ggc tcc cag gcc cgg cat gga gct ggc acg 192 Leu Met Ala Trp Leu Ala Gly Ser Gln Ala Arg His Gly Ala Gly Thr 50 55 60 cgt ctg gcg ctg ctc ctg ctc agc ctg gcc ctc tct gac ttc ttg ttc 240 Arg Leu Ala Leu Leu Leu Leu Ser Leu Ala Leu Ser Asp Phe Leu Phe 65 70 75 80 ctg gca gca gcg gcc ttc cag atc cta gag atc cgg cat ggg gga cac 288 Leu Ala Ala Ala Ala Phe Gln Ile Leu Glu Ile Arg His Gly Gly His 85 90 95 tgg ccg ctg ggg aca gct gcc tgc cgc ttc tac tac ttc cta tgg ggc 336 Trp Pro Leu Gly Thr Ala Ala Cys Arg Phe Tyr Tyr Phe Leu Trp Gly 100 105 110 gtg tcc tac tcc tcc ggc ctc ttc ctg ctg gcc gcc ctc agc ctc gac 384 Val Ser Tyr Ser Ser Gly Leu Phe Leu Leu Ala Ala Leu Ser Leu Asp 115 120 125 cgc tgc ctg ctg gcg ctg tgc cca cac tgg tac cct ggg cac cgc cca 432 Arg Cys Leu Leu Ala Leu Cys Pro His Trp Tyr Pro Gly His Arg Pro 130 135 140 gtc cgc ctg ccc ctc tgg gtc tgc gcc ggt gtc tgg gtg ctg gcc aca 480 Val Arg Leu Pro Leu Trp Val Cys Ala Gly Val Trp Val Leu Ala Thr 145 150 155 160 ctc ttc agc gtg ccc tgg ctg gtc ttc ccc gag gct gcc gtc tgg tgg 528 Leu Phe Ser Val Pro Trp Leu Val Phe Pro Glu Ala Ala Val Trp Trp 165 170 175 tac gac ctg gtc atc tgc ctg gac ttc tgg gac agc gag gag ctg tcg 576 Tyr Asp Leu Val Ile Cys Leu Asp Phe Trp Asp Ser Glu Glu Leu Ser 180 185 190 ctg agg atg ctg gag gtc ctg ggg ggc ttc ctg cct ttc ctc ctg ctg 624 Leu Arg Met Leu Glu Val Leu Gly Gly Phe Leu Pro Phe Leu Leu Leu 195 200 205 ctc gtc tgc cac gtg ctc acc cag gcc aca gcc tgt cgc acc tgc cac 672 Leu Val Cys His Val Leu Thr Gln Ala Thr Ala Cys Arg Thr Cys His 210 215 220 cgc caa cag cag ccc gca gcc tgc cgg ggc ttc gcc cgt gtg gcc agg 720 Arg Gln Gln Gln Pro Ala Ala Cys Arg Gly Phe Ala Arg Val Ala Arg 225 230 235 240 acc att ctg tca gcc tat gtg gtc ctg agg ctg ccc tac cag ctg gcc 768 Thr Ile Leu Ser Ala Tyr Val Val Leu Arg Leu Pro Tyr Gln Leu Ala 245 250 255 cag ctg ctc tac ctg gcc ttc ctg tgg gac gtc tac tct ggc tac ctg 816 Gln Leu Leu Tyr Leu Ala Phe Leu Trp Asp Val Tyr Ser Gly Tyr Leu 260 265 270 ctc tgg gag gcc ctg gtc tac tcc gac tac ctg atc cta ctc aac agc 864 Leu Trp Glu Ala Leu Val Tyr Ser Asp Tyr Leu Ile Leu Leu Asn Ser 275 280 285 tgc ctc agc ccc ttc ctc tgc ctc atg gcc agt gcc gac ctc cgg acc 912 Cys Leu Ser Pro Phe Leu Cys Leu Met Ala Ser Ala Asp Leu Arg Thr 290 295 300 ctg ctg cgc tcc gtg ctc tcg tcc ttc gcg gca gct ctc tgc gag gag 960 Leu Leu Arg Ser Val Leu Ser Ser Phe Ala Ala Ala Leu Cys Glu Glu 305 310 315 320 cgg ccg ggc agc ttc acg ccc act gag cca cag acc cag cta gat tct 1008 Arg Pro Gly Ser Phe Thr Pro Thr Glu Pro Gln Thr Gln Leu Asp Ser 325 330 335 gag ggt cca act ctg cca gag ccg atg gca gag gcc cag tca cag atg 1056 Glu Gly Pro Thr Leu Pro Glu Pro Met Ala Glu Ala Gln Ser Gln Met 340 345 350 gat cct gtg gcc cag cct cag gtg aac ccc aca ctc cag cca cga tcg 1104 Asp Pro Val Ala Gln Pro Gln Val Asn Pro Thr Leu Gln Pro Arg Ser 355 360 365 gat ccc aca gct cag cca cag ctg aac cct acg gcc cag cca cag tcg 1152 Asp Pro Thr Ala Gln Pro Gln Leu Asn Pro Thr Ala Gln Pro Gln Ser 370 375 380 gat ccc aca gcc cag cca cag ctg aac ctc atg gcc cag cca cag tca 1200 Asp Pro Thr Ala Gln Pro Gln Leu Asn Leu Met Ala Gln Pro Gln Ser 385 390 395 400 gat tct gtg gcc cag cca cag gca gac act aac gtc cag acc cct gca 1248 Asp Ser Val Ala Gln Pro Gln Ala Asp Thr Asn Val Gln Thr Pro Ala 405 410 415 cct gct gcc agt tct gtg ccc agt ccc tgt gat gaa gct tcc cca acc 1296 Pro Ala Ala Ser Ser Val Pro Ser Pro Cys Asp Glu Ala Ser Pro Thr 420 425 430 cca tcc tcg cat cct acc cca ggg gcc ctt gag gac cca gcc aca cct 1344 Pro Ser Ser His Pro Thr Pro Gly Ala Leu Glu Asp Pro Ala Thr Pro 435 440 445 cct gcc tct gaa gga gaa agc ccc agc agc acc ccg cca gag gcg gcc 1392 Pro Ala Ser Glu Gly Glu Ser Pro Ser Ser Thr Pro Pro Glu Ala Ala 450 455 460 ccg ggc gca ggc ccc acg tga 1413 Pro Gly Ala Gly Pro Thr 465 470 <210> 10 <211> 470 <212> PRT <213> Homo sapiens <400> 10 Met Asp Thr Thr Met Glu Ala Asp Leu Gly Ala Thr Gly His Arg Pro 1 5 10 15 Arg Thr Glu Leu Asp Asp Glu Asp Ser Tyr Pro Gln Gly Gly Trp Asp 20 25 30 Thr Val Phe Leu Val Ala Leu Leu Leu Leu Gly Leu Pro Ala Asn Gly 35 40 45 Leu Met Ala Trp Leu Ala Gly Ser Gln Ala Arg His Gly Ala Gly Thr 50 55 60 Arg Leu Ala Leu Leu Leu Leu Ser Leu Ala Leu Ser Asp Phe Leu Phe 65 70 75 80 Leu Ala Ala Ala Ala Phe Gln Ile Leu Glu Ile Arg His Gly Gly His 85 90 95 Trp Pro Leu Gly Thr Ala Ala Cys Arg Phe Tyr Tyr Phe Leu Trp Gly 100 105 110 Val Ser Tyr Ser Ser Gly Leu Phe Leu Leu Ala Ala Leu Ser Leu Asp 115 120 125 Arg Cys Leu Leu Ala Leu Cys Pro His Trp Tyr Pro Gly His Arg Pro 130 135 140 Val Arg Leu Pro Leu Trp Val Cys Ala Gly Val Trp Val Leu Ala Thr 145 150 155 160 Leu Phe Ser Val Pro Trp Leu Val Phe Pro Glu Ala Ala Val Trp Trp 165 170 175 Tyr Asp Leu Val Ile Cys Leu Asp Phe Trp Asp Ser Glu Glu Leu Ser 180 185 190 Leu Arg Met Leu Glu Val Leu Gly Gly Phe Leu Pro Phe Leu Leu Leu 195 200 205 Leu Val Cys His Val Leu Thr Gln Ala Thr Ala Cys Arg Thr Cys His 210 215 220 Arg Gln Gln Gln Pro Ala Ala Cys Arg Gly Phe Ala Arg Val Ala Arg 225 230 235 240 Thr Ile Leu Ser Ala Tyr Val Val Leu Arg Leu Pro Tyr Gln Leu Ala 245 250 255 Gln Leu Leu Tyr Leu Ala Phe Leu Trp Asp Val Tyr Ser Gly Tyr Leu 260 265 270 Leu Trp Glu Ala Leu Val Tyr Ser Asp Tyr Leu Ile Leu Leu Asn Ser 275 280 285 Cys Leu Ser Pro Phe Leu Cys Leu Met Ala Ser Ala Asp Leu Arg Thr 290 295 300 Leu Leu Arg Ser Val Leu Ser Ser Phe Ala Ala Ala Leu Cys Glu Glu 305 310 315 320 Arg Pro Gly Ser Phe Thr Pro Thr Glu Pro Gln Thr Gln Leu Asp Ser 325 330 335 Glu Gly Pro Thr Leu Pro Glu Pro Met Ala Glu Ala Gln Ser Gln Met 340 345 350 Asp Pro Val Ala Gln Pro Gln Val Asn Pro Thr Leu Gln Pro Arg Ser 355 360 365 Asp Pro Thr Ala Gln Pro Gln Leu Asn Pro Thr Ala Gln Pro Gln Ser 370 375 380 Asp Pro Thr Ala Gln Pro Gln Leu Asn Leu Met Ala Gln Pro Gln Ser 385 390 395 400 Asp Ser Val Ala Gln Pro Gln Ala Asp Thr Asn Val Gln Thr Pro Ala 405 410 415 Pro Ala Ala Ser Ser Val Pro Ser Pro Cys Asp Glu Ala Ser Pro Thr 420 425 430 Pro Ser Ser His Pro Thr Pro Gly Ala Leu Glu Asp Pro Ala Thr Pro 435 440 445 Pro Ala Ser Glu Gly Glu Ser Pro Ser Ser Thr Pro Pro Glu Ala Ala 450 455 460 Pro Gly Ala Gly Pro Thr 465 470 <210> 11 <211> 1119 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1119) <400> 11 atg tta gcc aac agc tcc tca acc aac agt tct gtt ctc ccg tgt cct 48 Met Leu Ala Asn Ser Ser Ser Thr Asn Ser Ser Val Leu Pro Cys Pro 1 5 10 15 gac tac cga cct acc cac cgc ctg cac ttg gtg gtc tac agc ttg gtg 96 Asp Tyr Arg Pro Thr His Arg Leu His Leu Val Val Tyr Ser Leu Val 20 25 30 ctg gct gcc ggg ctc ccc ctc aac gcg cta gcc ctc tgg gtc ttc ctg 144 Leu Ala Ala Gly Leu Pro Leu Asn Ala Leu Ala Leu Trp Val Phe Leu 35 40 45 cgc gcg ctg cgc gtg cac tcg gtg gtg agc gtg tac atg tgt aac ctg 192 Arg Ala Leu Arg Val His Ser Val Val Ser Val Tyr Met Cys Asn Leu 50 55 60 gcg gcc agc gac ctg ctc ttc acc ctc tcg ctg ccc gtt cgt ctc tcc 240 Ala Ala Ser Asp Leu Leu Phe Thr Leu Ser Leu Pro Val Arg Leu Ser 65 70 75 80 tac tac gca ctg cac cac tgg ccc ttc ccc gac ctc ctg tgc cag acg 288 Tyr Tyr Ala Leu His His Trp Pro Phe Pro Asp Leu Leu Cys Gln Thr 85 90 95 acg ggc gcc atc ttc cag atg aac atg tac ggc agc tgc atc ttc ctg 336 Thr Gly Ala Ile Phe Gln Met Asn Met Tyr Gly Ser Cys Ile Phe Leu 100 105 110 atg ctc atc aac gtg gac cgc tac gcc gcc atc gtg cac ccg ctg cga 384 Met Leu Ile Asn Val Asp Arg Tyr Ala Ala Ile Val His Pro Leu Arg 115 120 125 ctg cgc cac ctg cgg cgg ccc cgc gtg gcg cgg ctg ctc tgc ctg ggc 432 Leu Arg His Leu Arg Arg Pro Arg Val Ala Arg Leu Leu Cys Leu Gly 130 135 140 gtg tgg gcg ctc atc ctg gtg ttt gcc gtg ccc gcc gcc cgc gtg cac 480 Val Trp Ala Leu Ile Leu Val Phe Ala Val Pro Ala Ala Arg Val His 145 150 155 160 agg ccc tcg cgt tgc cgc tac cgg gac ctc gag gtg cgc cta tgc ttc 528 Arg Pro Ser Arg Cys Arg Tyr Arg Asp Leu Glu Val Arg Leu Cys Phe 165 170 175 gag agc ttc agc gac gag ctg tgg aaa ggc agg ctg ctg ccc ctc gtg 576 Glu Ser Phe Ser Asp Glu Leu Trp Lys Gly Arg Leu Leu Pro Leu Val 180 185 190 ctg ctg gcc gag gcg ctg ggc ttc ctg ctg ccc ctg gcg gcg gtg gtc 624 Leu Leu Ala Glu Ala Leu Gly Phe Leu Leu Pro Leu Ala Ala Val Val 195 200 205 tac tcg tcg ggc cga gtc ttc tgg acg ctg gcg cgc ccc gac gcc acg 672 Tyr Ser Ser Gly Arg Val Phe Trp Thr Leu Ala Arg Pro Asp Ala Thr 210 215 220 cag agc cag cgg cgg cgg aag acc gtg cgc ctc ctg ctg gct aac ctc 720 Gln Ser Gln Arg Arg Arg Lys Thr Val Arg Leu Leu Leu Ala Asn Leu 225 230 235 240 gtc atc ttc ctg ctg tgc ttc gtg ccc tac aac agc acg ctg gcg gtc 768 Val Ile Phe Leu Leu Cys Phe Val Pro Tyr Asn Ser Thr Leu Ala Val 245 250 255 tac ggg ctg ctg cgg agc aag ctg gtg gcg gcc agc gtg cct gcc cgc 816 Tyr Gly Leu Leu Arg Ser Lys Leu Val Ala Ala Ser Val Pro Ala Arg 260 265 270 gat cgc gtg cgc ggg gtg ctg atg gtg atg gtg ctg ctg gcc ggc gcc 864 Asp Arg Val Arg Gly Val Leu Met Val Met Val Leu Leu Ala Gly Ala 275 280 285 aac tgc gtg ctg gac ccg ctg gtg tac tac ttt agc gcc gag ggc ttc 912 Asn Cys Val Leu Asp Pro Leu Val Tyr Tyr Phe Ser Ala Glu Gly Phe 290 295 300 cgc aac acc ctg cgc ggc ctg ggc act ccg cac cgg gcc agg acc tcg 960 Arg Asn Thr Leu Arg Gly Leu Gly Thr Pro His Arg Ala Arg Thr Ser 305 310 315 320 gcc acc aac ggg acg cgg gcg gcg ctc gcg caa tcc gaa agg tcc gcc 1008 Ala Thr Asn Gly Thr Arg Ala Ala Leu Ala Gln Ser Glu Arg Ser Ala 325 330 335 gtc acc acc gac gcc acc agg ccg gat gcc gcc agt cag ggg ctg ctc 1056 Val Thr Thr Asp Ala Thr Arg Pro Asp Ala Ala Ser Gln Gly Leu Leu 340 345 350 cga ccc tcc gac tcc cac tct ctg tct tcc ttc aca cag tgt ccc cag 1104 Arg Pro Ser Asp Ser His Ser Leu Ser Ser Phe Thr Gln Cys Pro Gln 355 360 365 gat tcc gcc ctc tga 1119 Asp Ser Ala Leu 370 <210> 12 <211> 372 <212> PRT <213> Homo sapiens <400> 12 Met Leu Ala Asn Ser Ser Ser Thr Asn Ser Ser Val Leu Pro Cys Pro 1 5 10 15 Asp Tyr Arg Pro Thr His Arg Leu His Leu Val Val Tyr Ser Leu Val 20 25 30 Leu Ala Ala Gly Leu Pro Leu Asn Ala Leu Ala Leu Trp Val Phe Leu 35 40 45 Arg Ala Leu Arg Val His Ser Val Val Ser Val Tyr Met Cys Asn Leu 50 55 60 Ala Ala Ser Asp Leu Leu Phe Thr Leu Ser Leu Pro Val Arg Leu Ser 65 70 75 80 Tyr Tyr Ala Leu His His Trp Pro Phe Pro Asp Leu Leu Cys Gln Thr 85 90 95 Thr Gly Ala Ile Phe Gln Met Asn Met Tyr Gly Ser Cys Ile Phe Leu 100 105 110 Met Leu Ile Asn Val Asp Arg Tyr Ala Ala Ile Val His Pro Leu Arg 115 120 125 Leu Arg His Leu Arg Arg Pro Arg Val Ala Arg Leu Leu Cys Leu Gly 130 135 140 Val Trp Ala Leu Ile Leu Val Phe Ala Val Pro Ala Ala Arg Val His 145 150 155 160 Arg Pro Ser Arg Cys Arg Tyr Arg Asp Leu Glu Val Arg Leu Cys Phe 165 170 175 Glu Ser Phe Ser Asp Glu Leu Trp Lys Gly Arg Leu Leu Pro Leu Val 180 185 190 Leu Leu Ala Glu Ala Leu Gly Phe Leu Leu Pro Leu Ala Ala Val Val 195 200 205 Tyr Ser Ser Gly Arg Val Phe Trp Thr Leu Ala Arg Pro Asp Ala Thr 210 215 220 Gln Ser Gln Arg Arg Arg Lys Thr Val Arg Leu Leu Leu Ala Asn Leu 225 230 235 240 Val Ile Phe Leu Leu Cys Phe Val Pro Tyr Asn Ser Thr Leu Ala Val 245 250 255 Tyr Gly Leu Leu Arg Ser Lys Leu Val Ala Ala Ser Val Pro Ala Arg 260 265 270 Asp Arg Val Arg Gly Val Leu Met Val Met Val Leu Leu Ala Gly Ala 275 280 285 Asn Cys Val Leu Asp Pro Leu Val Tyr Tyr Phe Ser Ala Glu Gly Phe 290 295 300 Arg Asn Thr Leu Arg Gly Leu Gly Thr Pro His Arg Ala Arg Thr Ser 305 310 315 320 Ala Thr Asn Gly Thr Arg Ala Ala Leu Ala Gln Ser Glu Arg Ser Ala 325 330 335 Val Thr Thr Asp Ala Thr Arg Pro Asp Ala Ala Ser Gln Gly Leu Leu 340 345 350 Arg Pro Ser Asp Ser His Ser Leu Ser Ser Phe Thr Gln Cys Pro Gln 355 360 365 Asp Ser Ala Leu 370 <210> 13 <211> 1014 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1014) <400> 13 atg aat gag cca cta gac tat tta gca aat gct tct gat ttc ccc gat 48 Met Asn Glu Pro Leu Asp Tyr Leu Ala Asn Ala Ser Asp Phe Pro Asp 1 5 10 15 tat gca gct gct ttt gga aat tgc act gat gaa aac atc cca ctc aag 96 Tyr Ala Ala Ala Phe Gly Asn Cys Thr Asp Glu Asn Ile Pro Leu Lys 20 25 30 atg cac tac ctc cct gtt att tat ggc att atc ttc ctc gtg gga ttt 144 Met His Tyr Leu Pro Val Ile Tyr Gly Ile Ile Phe Leu Val Gly Phe 35 40 45 cca ggc aat gca gta gtg ata tcc act tac att ttc aaa atg aga cct 192 Pro Gly Asn Ala Val Val Ile Ser Thr Tyr Ile Phe Lys Met Arg Pro 50 55 60 tgg aag agc agc acc atc att atg ctg aac ctg gcc tgc aca gat ctg 240 Trp Lys Ser Ser Thr Ile Ile Met Leu Asn Leu Ala Cys Thr Asp Leu 65 70 75 80 ctg tat ctg acc agc ctc ccc ttc ctg att cac tac tat gcc agt ggc 288 Leu Tyr Leu Thr Ser Leu Pro Phe Leu Ile His Tyr Tyr Ala Ser Gly 85 90 95 gaa aac tgg atc ttt gga gat ttc atg tgt aag ttt atc cgc ttc agc 336 Glu Asn Trp Ile Phe Gly Asp Phe Met Cys Lys Phe Ile Arg Phe Ser 100 105 110 ttc cat ttc aac ctg tat agc agc atc ctc ttc ctc acc tgt ttc agc 384 Phe His Phe Asn Leu Tyr Ser Ser Ile Leu Phe Leu Thr Cys Phe Ser 115 120 125 atc ttc cgc tac tgt gtg atc att cac cca atg agc tgc ttt tcc att 432 Ile Phe Arg Tyr Cys Val Ile Ile His Pro Met Ser Cys Phe Ser Ile 130 135 140 cac aaa act cga tgt gca gtt gta gcc tgt gct gtg gtg tgg atc att 480 His Lys Thr Arg Cys Ala Val Val Ala Cys Ala Val Val Trp Ile Ile 145 150 155 160 tca ctg gta gct gtc att ccg atg acc ttc ttg atc aca tca acc aac 528 Ser Leu Val Ala Val Ile Pro Met Thr Phe Leu Ile Thr Ser Thr Asn 165 170 175 agg acc aac aga tca gcc tgt ctc gac ctc acc agt tcg gat gaa ctc 576 Arg Thr Asn Arg Ser Ala Cys Leu Asp Leu Thr Ser Ser Asp Glu Leu 180 185 190 aat act att aag tgg tac aac ctg att ttg act gca act act ttc tgc 624 Asn Thr Ile Lys Trp Tyr Asn Leu Ile Leu Thr Ala Thr Thr Phe Cys 195 200 205 ctc ccc ttg gtg ata gtg aca ctt tgc tat acc acg att atc cac act 672 Leu Pro Leu Val Ile Val Thr Leu Cys Tyr Thr Thr Ile Ile His Thr 210 215 220 ctg acc cat gga ctg caa act gac agc tgc ctt aag cag aaa gca cga 720 Leu Thr His Gly Leu Gln Thr Asp Ser Cys Leu Lys Gln Lys Ala Arg 225 230 235 240 agg cta acc att ctg cta ctc ctt gca ttt tac gta tgt ttt tta ccc 768 Arg Leu Thr Ile Leu Leu Leu Leu Ala Phe Tyr Val Cys Phe Leu Pro 245 250 255 ttc cat atc ttg agg gtc att cgg atc gaa tct cgc ctg ctt tca atc 816 Phe His Ile Leu Arg Val Ile Arg Ile Glu Ser Arg Leu Leu Ser Ile 260 265 270 agt tgt tcc att gag aat cag atc cat gaa gct tac atc gtt tct aga 864 Ser Cys Ser Ile Glu Asn Gln Ile His Glu Ala Tyr Ile Val Ser Arg 275 280 285 cca tta gct gct ctg aac acc ttt ggt aac ctg tta cta tat gtg gtg 912 Pro Leu Ala Ala Leu Asn Thr Phe Gly Asn Leu Leu Leu Tyr Val Val 290 295 300 gtc agc gac aac ttt cag cag gct gtc tgc tca aca gtg aga tgc aaa 960 Val Ser Asp Asn Phe Gln Gln Ala Val Cys Ser Thr Val Arg Cys Lys 305 310 315 320 gta agc ggg aac ctt gag caa gca aag aaa att agt tac tca aac aac 1008 Val Ser Gly Asn Leu Glu Gln Ala Lys Lys Ile Ser Tyr Ser Asn Asn 325 330 335 cct tga 1014 Pro <210> 14 <211> 337 <212> PRT <213> Homo sapiens <400> 14 Met Asn Glu Pro Leu Asp Tyr Leu Ala Asn Ala Ser Asp Phe Pro Asp 1 5 10 15 Tyr Ala Ala Ala Phe Gly Asn Cys Thr Asp Glu Asn Ile Pro Leu Lys 20 25 30 Met His Tyr Leu Pro Val Ile Tyr Gly Ile Ile Phe Leu Val Gly Phe 35 40 45 Pro Gly Asn Ala Val Val Ile Ser Thr Tyr Ile Phe Lys Met Arg Pro 50 55 60 Trp Lys Ser Ser Thr Ile Ile Met Leu Asn Leu Ala Cys Thr Asp Leu 65 70 75 80 Leu Tyr Leu Thr Ser Leu Pro Phe Leu Ile His Tyr Tyr Ala Ser Gly 85 90 95 Glu Asn Trp Ile Phe Gly Asp Phe Met Cys Lys Phe Ile Arg Phe Ser 100 105 110 Phe His Phe Asn Leu Tyr Ser Ser Ile Leu Phe Leu Thr Cys Phe Ser 115 120 125 Ile Phe Arg Tyr Cys Val Ile Ile His Pro Met Ser Cys Phe Ser Ile 130 135 140 His Lys Thr Arg Cys Ala Val Val Ala Cys Ala Val Val Trp Ile Ile 145 150 155 160 Ser Leu Val Ala Val Ile Pro Met Thr Phe Leu Ile Thr Ser Thr Asn 165 170 175 Arg Thr Asn Arg Ser Ala Cys Leu Asp Leu Thr Ser Ser Asp Glu Leu 180 185 190 Asn Thr Ile Lys Trp Tyr Asn Leu Ile Leu Thr Ala Thr Thr Phe Cys 195 200 205 Leu Pro Leu Val Ile Val Thr Leu Cys Tyr Thr Thr Ile Ile His Thr 210 215 220 Leu Thr His Gly Leu Gln Thr Asp Ser Cys Leu Lys Gln Lys Ala Arg 225 230 235 240 Arg Leu Thr Ile Leu Leu Leu Leu Ala Phe Tyr Val Cys Phe Leu Pro 245 250 255 Phe His Ile Leu Arg Val Ile Arg Ile Glu Ser Arg Leu Leu Ser Ile 260 265 270 Ser Cys Ser Ile Glu Asn Gln Ile His Glu Ala Tyr Ile Val Ser Arg 275 280 285 Pro Leu Ala Ala Leu Asn Thr Phe Gly Asn Leu Leu Leu Tyr Val Val 290 295 300 Val Ser Asp Asn Phe Gln Gln Ala Val Cys Ser Thr Val Arg Cys Lys 305 310 315 320 Val Ser Gly Asn Leu Glu Gln Ala Lys Lys Ile Ser Tyr Ser Asn Asn 325 330 335 Pro <210> 15 <211> 993 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(993) <400> 15 atg gat cca acc acc ccg gcc tgg gga aca gaa agt aca aca gtg aat 48 Met Asp Pro Thr Thr Pro Ala Trp Gly Thr Glu Ser Thr Thr Val Asn 1 5 10 15 gga aat gac caa gcc ctt ctt ctg ctt tgt ggc aag gag acc ctg atc 96 Gly Asn Asp Gln Ala Leu Leu Leu Leu Cys Gly Lys Glu Thr Leu Ile 20 25 30 ccg gtc ttc ctg atc ctt ttc att gcc ctg gtc ggg ctg gta gga aac 144 Pro Val Phe Leu Ile Leu Phe Ile Ala Leu Val Gly Leu Val Gly Asn 35 40 45 ggg ttt gtg ctc tgg ctc ctg ggc ttc cgc atg cgc agg aac gcc ttc 192 G ly Phe Val Leu Trp Leu Leu Gly Phe Arg Met Arg Arg Asn Ala Phe 50 55 60 tct gtc tac gtc ctc agc ctg gcc ggg gcc gac ttc ctc ttc ctc tgc 240 Ser Val Tyr Val Leu Ser Leu Ala Gly Ala Asp Phe Leu Phe Leu Cys 65 70 75 80 ttc cag att ata aat tgc ctg gtg tac ctc agt aac ttc ttc tgt tcc 288 Phe Gln Ile Ile Asn Cys Leu Val Tyr Leu Ser Asn Phe Phe Cys Ser 85 90 95 atc tcc atc aat ttc cct agc ttc ttc acc act gtg atg acc tgt gcc 336 Ile Ser Ile Asn Phe Pro Ser Phe Phe Thr Thr Val Met Thr Cys Ala 100 105 110 tac ctt gca ggc ctg agc atg ctg agc acc gtc agc acc gag cgc tgc 384 Tyr Leu Ala Gly Leu Ser Met Leu Ser Thr Val Ser Thr Glu Arg Cys 115 120 125 ctg tcc gtc ctg tgg ccc atc tgg tat cgc tgc cgc cgc ccc aga cac 432 Leu Ser Val Leu Trp Pro Ile Trp Tyr Arg Cys Arg Arg Pro Arg His 130 135 140 ctg tca gcg gtc gtg tgt gtc ctg ctc tgg gcc ctg tcc cta ctg ctg 480 Leu Ser Ala Val Val Cys Val Leu Leu Trp Ala Leu Ser Leu Leu Leu 145 150 155 160 agc atc ttg gaa ggg aag ttc tgt ggc ttc tta ttt agt gat ggt gac 528 Ser Ile Leu Glu Gly Lys Phe Cys Gly Phe Leu Phe Ser Asp Gly Asp 165 170 175 tct ggt tgg tgt cag aca ttt gat ttc atc act gca gcg tgg ctg att 576 Ser Gly Trp Cys Gln Thr Phe Asp Phe Ile Thr Ala Ala Trp Leu Ile 180 185 190 ttt tta ttc atg gtt ctc tgt ggg tcc agt ctg gcc ctg ctg gtc agg 624 Phe Leu Phe Met Val Leu Cys Gly Ser Ser Leu Ala Leu Leu Val Arg 195 200 205 atc ctc tgt ggc tcc agg ggt ctg cca ctg acc agg ctg tac ctg acc 672 Ile Leu Cys Gly Ser Arg Gly Leu Pro Leu Thr Arg Leu Tyr Leu Thr 210 215 220 atc ctg ctc aca gtg ctg gtg ttc ctc ctc tgc ggc ctg ccc ttt ggc 720 Ile Leu Leu Thr Val Leu Val Phe Leu Leu Cys Gly Leu Pro Phe Gly 225 230 235 240 att cag tgg ttc cta ata tta tgg atc tgg aag gat tct gat gtc tta 768 Ile Gln Trp Phe Leu Ile Leu Trp Ile Trp Lys Asp Ser Asp Val Leu 245 250 255 ttt tgt cat att cat cca gtt tca gtt gtc ctg tca tct ctt aac agc 816 Phe Cys His Ile His Pro Val Ser Val Val Leu Ser Ser Leu Asn Ser 260 265 270 agt gcc aac ccc atc att tac ttc ttc gtg ggc tct ttt agg aag cag 864 Ser Ala Asn Pro Ile Ile Tyr Phe Phe Val Gly Ser Phe Arg Lys Gln 275 280 285 tgg cgg ctg cag cag ccg atc ctc aag ctg gct ctc cag agg gct ctg 912 Trp Arg Leu Gln Gln Pro Ile Leu Lys Leu Ala Leu Gln Arg Ala Leu 290 295 300 cag gac att gct gag gtg gat cac agt gaa gga tgc ttc cgt cag ggc 960 Gln Asp Ile Ala Glu Val Asp His Ser Glu Gly Cys Phe Arg Gln Gly 305 310 315 320 acc ccg gag atg tcg aga agc agt ctg gtg tag 993 Thr Pro Glu Met Ser Arg Ser Ser Leu Val 325 330 <210> 16 <211> 330 <212> PRT <213> Homo sapiens <400> 16 Met Asp Pro Thr Thr Pro Ala Trp Gly Thr Glu Ser Thr Thr Val Asn 1 5 10 15 Gly Asn Asp Gln Ala Leu Leu Leu Leu Cys Gly Lys Glu Thr Leu Ile 20 25 30 Pro Val Phe Leu Ile Leu Phe Ile Ala Leu Val Gly Leu Val Gly Asn 35 40 45 Gly Phe Val Leu Trp Leu Leu Gly Phe Arg Met Arg Arg Asn Ala Phe 50 55 60 Ser Val Tyr Val Leu Ser Leu Ala Gly Ala Asp Phe Leu Phe Leu Cys 65 70 75 80 Phe Gln Ile Ile Asn Cys Leu Val Tyr Leu Ser Asn Phe Phe Cys Ser 85 90 95 Ile Ser Ile Asn Phe Pro Ser Phe Phe Thr Thr Val Met Thr Cys Ala 100 105 110 Tyr Leu Ala Gly Leu Ser Met Leu Ser Thr Val Ser Thr Glu Arg Cys 115 120 125 Leu Ser Val Leu Trp Pro Ile Trp Tyr Arg Cys Arg Arg Pro Arg His 130 135 140 Leu Ser Ala Val Val Cys Val Leu Leu Trp Ala Leu Ser Leu Leu Leu 145 150 155 160 Ser Ile Leu Glu Gly Lys Phe Cys Gly Phe Leu Phe Ser Asp Gly Asp 165 170 175 Ser Gly Trp Cys Gln Thr Phe Asp Phe Ile Thr Ala Ala Trp Leu Ile 180 185 190 Phe Leu Phe Met Val Leu Cys Gly Ser Ser Leu Ala Leu Leu Val Arg 195 200 205 Ile Leu Cys Gly Ser Arg Gly Leu Pro Leu Thr Arg Leu Tyr Leu Thr 210 215 220 Ile Leu Leu Thr Val Leu Val Phe Leu Leu Cys Gly Leu Pro Phe Gly 225 230 235 240 Ile Gln Trp Phe Leu Ile Leu Trp Ile Trp Lys Asp Ser Asp Val Leu 245 250 255 Phe Cys His Ile His Pro Val Ser Val Val Leu Ser Ser Leu Asn Ser 260 265 270 Ser Ala Asn Pro Ile Ile Tyr Phe Phe Val Gly Ser Phe Arg Lys Gln 275 280 285 Trp Arg Leu Gln Gln Pro Ile Leu Lys Leu Ala Leu Gln Arg Ala Leu 290 295 300 Gln Asp Ile Ala Glu Val Asp His Ser Glu Gly Cys Phe Arg Gln Gly 305 310 315 320 Thr Pro Glu Met Ser Arg Ser Ser Leu Val 325 330 <210> 17 <211> 1011 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1011) <400> 17 atg aac aac aat aca aca tgt att caa cca tct atg atc tct tcc atg 48 Met Asn Asn Asn Thr Thr Cys Ile Gln Pro Ser Met Ile Ser Ser Met 1 5 10 15 gct tta cca atc att tac atc ctc ctt tgt att gtt ggt gtt ttt gga 96 Ala Leu Pro Ile Ile Tyr Ile Leu Leu Cys Ile Val Gly Val Phe Gly 20 25 30 aac act ctc tct caa tgg ata ttt tta aca aaa ata ggt aaa aaa aca 144 Asn Thr Leu Ser Gln Trp Ile Phe Leu Thr Lys Ile Gly Lys Lys Thr 35 40 45 tca acg cac atc tac ctg tca cac ctt gtg act gca aac tta ctt gtg 192 Ser Thr His Ile Tyr Leu Ser His Leu Val Thr Ala Asn Leu Leu Val 50 55 60 tgc agt gcc atg cct ttc atg agt atc tat ttc ctg aaa ggt ttc caa 240 Cys Ser Ala Met Pro Phe Met Ser Ile Tyr Phe Leu Lys Gly Phe Gln 65 70 75 80 tgg gaa tat caa tct gct caa tgc aga gtg gtc aat ttt ctg gga act 288 Trp Glu Tyr Gln Ser Ala Gln Cys Arg Val Val Asn Phe Leu Gly Thr 85 90 95 cta tcc atg cat gca agt atg ttt gtc agt ctc tta att tta agt tgg 336 Leu Ser Met His Ala Ser Met Phe Val Ser Leu Leu Ile Leu Ser Trp 100 105 110 att gcc ata agc cgc tat gct acc tta atg caa aag gat tcc tcg caa 384 Ile Ala Ile Ser Arg Tyr Ala Thr Leu Met Gln Lys Asp Ser Ser Gln 115 120 125 gag act act tca tgc tat gag aaa ata ttt tat ggc cat tta ctg aaa 432 Glu Thr Thr Ser Cys Tyr Glu Lys Ile Phe Tyr Gly His Leu Leu Lys 130 135 140 aaa ttt cgc cag ccc aac ttt gct aga aaa cta tgc att tac ata tgg 480 Lys Phe Arg Gln Pro Asn Phe Ala Arg Lys Leu Cys Ile Tyr Ile Trp 145 150 155 160 gga gtt gta ctg ggc ata atc att cca gtt acc gta tac tac tca gtc 528 Gly Val Val Leu Gly Ile Ile Ile Pro Val Thr Val Tyr Tyr Ser Val 165 170 175 ata gag gct aca gaa gga gaa gag agc cta tgc tac aat cgg cag atg 576 Ile Glu Ala Thr Glu Gly Glu Glu Ser Leu Cys Tyr Asn Arg Gln Met 180 185 190 gaa cta gga gcc atg atc tct cag att gca ggt ctc att gga acc aca 624 Glu Leu Gly Ala Met Ile Ser Gln Ile Ala Gly Leu Ile Gly Thr Thr 195 200 205 ttt att gga ttt tcc ttt tta gta gta cta aca tca tac tac tct ttt 672 Phe Ile Gly Phe Ser Phe Leu Val Val Leu Thr Ser Tyr Tyr Ser Phe 210 215 220 gta agc cat ctg aga aaa ata aga acc tgt acg tcc att atg gag aaa 720 Val Ser His Leu Arg Lys Ile Arg Thr Cys Thr Ser Ile Met Glu Lys 225 230 235 240 gat ttg act tac agt tct gtg aaa aga cat ctt ttg gtc atc cag att 768 Asp Leu Thr Tyr Ser Ser Val Lys Arg His Leu Leu Val Ile Gln Ile 245 250 255 cta cta ata gtt tgc ttc ctt cct tat agt att ttt aaa ccc att ttt 816 Leu Leu Ile Val Cys Phe Leu Pro Tyr Ser Ile Phe Lys Pro Ile Phe 260 265 270 tat gtt cta cac caa aga gat aac tgt cag caa ttg aat tat tta ata 864 Tyr Val Leu His Gln Arg Asp Asn Cys Gln Gln Leu Asn Tyr Leu Ile 275 280 285 gaa aca aaa aac att ctc acc tgt ctt gct tcg gcc aga agt agc aca 912 Glu Thr Lys Asn Ile Leu Thr Cys Leu Ala Ser Ala Arg Ser Ser Thr 290 295 300 gac ccc att ata ttt ctt tta tta gat aaa aca ttc aag aag aca cta 960 Asp Pro Ile Ile Phe Leu Leu Leu Asp Lys Thr Phe Lys Lys Thr Leu 305 310 315 320 tat aat ctc ttt aca aag tct aat tca gca cat atg caa tca tat ggt 1008 Tyr Asn Leu Phe Thr Lys Ser Asn Ser Ala His Met Gln Ser Tyr Gly 325 330 335 tga 1011 <210> 18 <211> 336 <212> PRT <213> Homo sapiens <400> 18 Met Asn Asn Asn Thr Thr Cys Ile Gln Pro Ser Met Ile Ser Ser Met 1 5 10 15 Ala Leu Pro Ile Ile Tyr Ile Leu Leu Cys Ile Val Gly Val Phe Gly 20 25 30 Asn Thr Leu Ser Gln Trp Ile Phe Leu Thr Lys Ile Gly Lys Lys Thr 35 40 45 Ser Thr His Ile Tyr Leu Ser His Leu Val Thr Ala Asn Leu Leu Val 50 55 60 Cys Ser Ala Met Pro Phe Met Ser Ile Tyr Phe Leu Lys Gly Phe Gln 65 70 75 80 Trp Glu Tyr Gln Ser Ala Gln Cys Arg Val Val Asn Phe Leu Gly Thr 85 90 95 Leu Ser Met His Ala Ser Met Phe Val Ser Leu Leu Ile Leu Ser Trp 100 105 110 Ile Ala Ile Ser Arg Tyr Ala Thr Leu Met Gln Lys Asp Ser Ser Gln 115 120 125 Glu Thr Thr Ser Cys Tyr Glu Lys Ile Phe Tyr Gly His Leu Leu Lys 130 135 140 Lys Phe Arg Gln Pro Asn Phe Ala Arg Lys Leu Cys Ile Tyr Ile Trp 145 150 155 160 Gly Val Val Leu Gly Ile Ile Ile Pro Val Thr Val Tyr Tyr Ser Val 165 170 175 Ile Glu Ala Thr Glu Gly Glu Glu Ser Leu Cys Tyr Asn Arg Gln Met 180 185 190 Glu Leu Gly Ala Met Ile Ser Gln Ile Ala Gly Leu Ile Gly Thr Thr 195 200 205 Phe Ile Gly Phe Ser Phe Leu Val Val Leu Thr Ser Tyr Tyr Ser Phe 210 215 220 Val Ser His Leu Arg Lys Ile Arg Thr Cys Thr Ser Ile Met Glu Lys 225 230 235 240 Asp Leu Thr Tyr Ser Ser Val Lys Arg His Leu Leu Val Ile Gln Ile 245 250 255 Leu Leu Ile Val Cys Phe Leu Pro Tyr Ser Ile Phe Lys Pro Ile Phe 260 265 270 Tyr Val Leu His Gln Arg Asp Asn Cys Gln Gln Leu Asn Tyr Leu Ile 275 280 285 Glu Thr Lys Asn Ile Leu Thr Cys Leu Ala Ser Ala Arg Ser Ser Thr 290 295 300 Asp Pro Ile Ile Phe Leu Leu Leu Asp Lys Thr Phe Lys Lys Thr Leu 305 310 315 320 Tyr Asn Leu Phe Thr Lys Ser Asn Ser Ala His Met Gln Ser Tyr Gly 325 330 335 <210> 19 <211> 1044 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1044) <400> 19 atg ggg gat gag ctg gca cct tgc cct gtg ggc act aca gct tgg ccg 48 Met Gly Asp Glu Leu Ala Pro Cys Pro Val Gly Thr Thr Ala Trp Pro 1 5 10 15 gcc ctg atc cag ctc atc agc aag aca ccc tgc atg ccc caa gca gcc 96 Ala Leu Ile Gln Leu Ile Ser Lys Thr Pro Cys Met Pro Gln Ala Ala 20 25 30 agc aac act tcc ttg ggc ctg ggg gac ctc agg gtg ccc agc tcc atg 144 Ser Asn Thr Ser Leu Gly Leu Gly Asp Leu Arg Val Pro Ser Ser Met 35 40 45 ctg tac tgg ctt ttc ctt ccc tca agc ctg ctg gct gca gcc aca ctg 192 Leu Tyr Trp Leu Phe Leu Pro Ser Ser Leu Leu Ala Ala Ala Thr Leu 50 55 60 gct gtc agc ccc ctg ctg ctg gtg acc atc ctg cgg aac caa cgg ctg 240 Ala Val Ser Pro Leu Leu Leu Val Thr Ile Leu Arg Asn Gln Arg Leu 65 70 75 80 cga cag gag ccc cac tac ctg ctc ccg gct aac atc ctg ctc tca gac 288 Arg Gln Glu Pro His Tyr Leu Leu Pro Ala Asn Ile Leu Leu Ser Asp 85 90 95 ctg gcc tac att ctc ctc cac atg ctc atc tcc tcc agc agc ctg ggt 336 Leu Ala Tyr Ile Leu Leu His Met Leu Ile Ser Ser Ser Ser Leu Gly 100 105 110 ggc tgg gag ctg ggc cgc atg gcc tgt ggc att ctc act gat gct gtc 384 Gly Trp Glu Leu Gly Arg Met Ala Cys Gly Ile Leu Thr Asp Ala Val 115 120 125 ttc gcc gcc tgc acc agc acc atc ctg tcc ttc acc gcc att gtg ctg 432 Phe Ala Ala Cys Thr Ser Thr Ile Leu Ser Phe Thr Ala Ile Val Leu 130 135 140 cac acc tac ctg gca gtc atc cat cca ctg cgc tac ctc tcc ttc atg 480 His Thr Tyr Leu Ala Val Ile His Pro Leu Arg Tyr Leu Ser Phe Met 145 150 155 160 tcc cat ggg gct gcc tgg aag gca gtg gcc ctc atc tgg ctg gtg gcc 528 Ser His Gly Ala Ala Trp Lys Ala Val Ala Leu Ile Trp Leu Val Ala 165 170 175 tgc tgc ttc ccc aca ttc ctt att tgg ctc agc aag tgg cag gat gcc 576 Cys Cys Phe Pro Thr Phe Leu Ile Trp Leu Ser Lys Trp Gln Asp Ala 180 185 190 cag ctg gag gag caa gga gct tca tac atc cta cca cca agc atg ggc 624 Gln Leu Glu Glu Gln Gly Ala Ser Tyr Ile Leu Pro Pro Ser Met Gly 195 200 205 acc cag ccg gga tgt ggc ctc ctg gtc att gtt acc tac acc tcc att 672 Thr Gln Pro Gly Cys Gly Leu Leu Val Ile Val Thr Tyr Thr Ser Ile 210 215 220 ctg tgc gtt ctg ttc ctc tgc aca gct ctc att gcc aac tgt ttc tgg 720 Leu Cys Val Leu Phe Leu Cys Thr Ala Leu Ile Ala Asn Cys Phe Trp 225 230 235 240 agg atc tat gca gag gcc aag act tca ggc atc tgg ggg cag ggc tat 768 Arg Ile Tyr Ala Glu Ala Lys Thr Ser Gly Ile Trp Gly Gln Gly Tyr 245 250 255 tcc cgg gcc agg ggc acc ctg ctg atc cac tca gtg ctg atc aca ttg 816 Ser Arg Ala Arg Gly Thr Leu Leu Ile His Ser Val Leu Ile Thr Leu 260 265 270 ta c gtg agc aca ggg gtg gtg ttc tcc ctg gac atg gtg ctg acc agg 864 Tyr Val Ser Thr Gly Val Val Phe Ser Leu Asp Met Val Leu Thr Arg 275 280 285 tac cac cac att gac tct ggg act cac aca tgg ctc ctg gca gct aac 912 Tyr His His Ile Asp Ser Gly Thr His Thr Trp Leu Leu Ala Ala Asn 290 295 300 agt gag gta ctc atg atg ctt ccc cgt gcc atg ctc aca tac ctg tac 960 Ser Glu Val Leu Met Met Leu Pro Arg Ala Met Leu Thr Tyr Leu Tyr 305 310 315 320 ctg ctc cgc tac cgg cag ctg ttg ggc atg gtc cgg ggc cac ctc cca 1008 Leu Leu Arg Tyr Arg Gln Leu Leu Gly Met Val Arg Gly His Leu Pro 325 330 335 tcc agg agg cac cag gcc atc ttt acc att tcc tag 1044 Ser Arg Arg His Gln Ala Ile Phe Thr Ile Ser 340 345 <210> 20 <211> 347 <212> PRT <213> Homo sapiens <400> 20 Met Gly Asp Glu Leu Ala Pro Cys Pro Val Gly Thr Thr Ala Trp Pro 1 5 10 15 Ala Leu Ile Gln Leu Ile Ser Lys Thr Pro Cys Met Pro Gln Ala Ala 20 25 30 Ser Asn Thr Ser Leu Gly Leu Gly Asp Leu Arg Val Pro Ser Ser Met 35 40 45 Leu Tyr Trp Leu Phe Leu Pro Ser Ser Leu Leu Ala Ala Ala Thr Leu 50 55 60 Ala Val Ser Pro Leu Leu Leu Val Thr Ile Leu Arg Asn Gln Arg Leu 65 70 75 80 Arg Gln Glu Pro His Tyr Leu Leu Pro Ala Asn Ile Leu Leu Ser Asp 85 90 95 Leu Ala Tyr Ile Leu Leu His Met Leu Ile Ser Ser Ser Ser Leu Gly 100 105 110 Gly Trp Glu Leu Gly Arg Met Ala Cys Gly Ile Leu Thr Asp Ala Val 115 120 125 Phe Ala Ala Cys Thr Ser Thr Ile Leu Ser Phe Thr Ala Ile Val Leu 130 135 140 His Thr Tyr Leu Ala Val Ile His Pro Leu Arg Tyr Leu Ser Phe Met 145 150 155 160 Ser His Gly Ala Ala Trp Lys Ala Val Ala Leu Ile Trp Leu Val Ala 165 170 175 Cys Cys Phe Pro Thr Phe Leu Ile Trp Leu Ser Lys Trp Gln Asp Ala 180 185 190 Gln Leu Glu Glu Gln Gly Ala Ser Tyr Ile Leu Pro Pro Ser Met Gly 195 200 205 Thr Gln Pro Gly Cys Gly Leu Leu Val Ile Val Thr Tyr Thr Ser Ile 210 215 220 Leu Cys Val Leu Phe Leu Cys Thr Ala Leu Ile Ala Asn Cys Phe Trp 225 230 235 240 Arg Ile Tyr Ala Glu Ala Lys Thr Ser Gly Ile Trp Gly Gln Gly Tyr 245 250 255 Ser Arg Ala Arg Gly Thr Leu Leu Ile His Ser Val Leu Ile Thr Leu 260 265 270 Tyr Val Ser Thr Gly Val Val Phe Ser Leu Asp Met Val Leu Thr Arg 275 280 285 Tyr His His Ile Asp Ser Gly Thr His Thr Trp Leu Leu Ala Ala Asn 290 295 300 Ser Glu Val Leu Met Met Leu Pro Arg Ala Met Leu Thr Tyr Leu Tyr 305 310 315 320 Leu Leu Arg Tyr Arg Gln Leu Leu Gly Met Val Arg Gly His Leu Pro 325 330 335 Ser Arg Arg His Gln Ala Ile Phe Thr Ile Ser 340 345 <210> 21 <211> 1158 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1158) <400> 21 atg gag agg tct ttt ctt tcc gcc gcg gcc gag caa ttg tgt nnn nnn 48 Met Glu Arg Ser Phe Leu Ser Ala Ala Ala Glu Gln Leu Cys Xaa Xaa 1 5 10 15 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 96 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 20 25 30 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn ntg 144 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 35 40 45 agg tcc ctg cct agg ccc cat agg agc caa cga agt cat ctt tgc ttc 192 Arg Ser Leu Pro Arg Pro His Arg Ser Gln Arg Ser His Leu Cys Phe 50 55 60 aga gct aaa cca gtt ttt ctt ctc tcc aca gca aat atc ttg aca gtg 240 Arg Ala Lys Pro Val Phe Leu Leu Ser Thr Ala Asn Ile Leu Thr Val 65 70 75 80 atc atc ctc tcc cag ctg gtg gca aga aga cag aag tcc tcc tac aac 288 Ile Ile Leu Ser Gln Leu Val Ala Arg Arg Gln Lys Ser Ser Tyr Asn 85 90 95 tat ctc ttg gca ctc gct gct gcc gac atc ttg gtc ctc ttt ttc ata 336 Tyr Leu Leu Ala Leu Ala Ala Ala Asp Ile Leu Val Leu Phe Phe Ile 100 105 110 gtg ttt gtg gac ttc ctg ttg gaa gat ttc atc ttg aac atg cag atg 384 Val Phe Val Asp Phe Leu Leu Glu Asp Phe Ile Leu Asn Met Gln Met 115 120 125 cct cag gtc ccc gac aag atc ata gaa gtg ctg gaa ttc tca tcc atc 432 Pro Gln Val Pro Asp Lys Ile Ile Glu Val Leu Glu Phe Ser Ser Ile 130 135 140 cac acc tcc ata tgg att act gta ccg tta acc att gac agg tat atc 480 His Thr Ser Ile Trp Ile Thr Val Pro Leu Thr Ile Asp Arg Tyr Ile 145 150 155 160 gct gtc tgc cac ccg ctc aag tac cac acg gtc tca tac cca gcc cgc 528 Ala Val Cys His Pro Leu Lys Tyr His Thr Val Ser Tyr Pro Ala Arg 165 170 175 acc cgg aaa gtc att gta agt gtt tac atc acc tgc ttc ctg acc agc 576 Thr Arg Lys Val Ile Val Ser Val Tyr Ile Thr Cys Phe Leu Thr Ser 180 185 190 atc ccc tat tac tgg tgg ccc aac atc tgg act gaa gac tac atc agc 624 Ile Pro Tyr Tyr Trp Trp Pro Asn Ile Trp Thr Glu Asp Tyr Ile Ser 195 200 205 acc tct gtg cat cac gtc ctc atc tgg atc cac tgc ttc acc gtc tac 672 Thr Ser Val His His Val Leu Ile Trp Ile His Cys Phe Thr Val Tyr 210 215 220 ctg gtg ccc tgc tcc atc ttc ttc atc ttg aac tca atc att gtg tac 720 Leu Val Pro Cys Ser Ile Phe Phe Ile Leu Asn Ser Ile Ile Val Tyr 225 230 235 240 aag ctc agg agg aag agc aat ttt cgt ctc cgt ggc tac tcc acg ggg 768 Lys Leu Arg Arg Lys Ser Asn Phe Arg Leu Arg Gly Tyr Ser Thr Gly 245 250 255 aag acc acc gcc atc ttg ttc acc att acc tcc atc ttt gcc aca ctt 816 Lys Thr Thr Ala Ile Leu Phe Thr Ile Thr Ser Ile Phe Ala Thr Leu 260 265 270 tgg gcc ccc cgc atc atc atg att ctt tac cac ctc tat ggg gcg ccc 864 Trp Ala Pro Arg Ile Ile Met Ile Leu Tyr His Leu Tyr Gly Ala Pro 275 280 285 atc cag aac cgc tgg ctg gta cac atc atg tcc gac att gcc aac atg 912 Ile Gln Asn Arg Trp Leu Val His Ile Met Ser Asp Ile Ala Asn Met 290 295 300 cta gcc ctt ctg aac aca gcc atc aac ttc ttc ctc tac tgc ttc atc 960 Leu Ala Leu Leu Asn Thr Ala Ile Asn Phe Phe Leu Tyr Cys Phe Ile 305 310 315 320 agc aag cgg ttc cgc acc atg gca gcc gcc acg ctc aag gct ttc ttc 1008 Ser Lys Arg Phe Arg Thr Met Ala Ala Ala Thr Leu Lys Ala Phe Phe 325 330 335 aag tgc cag aag caa cct gta cag ttc tac acc aat cat aac ttt tcc 1056 Lys Cys Gln Lys Gln Pro Val Gln Phe Tyr Thr Asn His Asn Phe Ser 340 345 350 ata aca agt agc ccc tgg atc tcg ccg gca aac tca cac tgc atc aag 1104 Ile Thr Ser Ser Pro Trp Ile Ser Pro Ala Asn Ser His Cys Ile Lys 355 360 365 atg ctg gtg tac cag tat gac aaa aat gga aaa cct ata aaa gta tcc 1152 Met Leu Val Tyr Gln Tyr Asp Lys Asn Gly Lys Pro Ile Lys Val Ser 370 375 380 ccg tga 1158 Pro 385 <210> 22 <211> 385 <212> PRT <213> Homo sapiens <400> 22 Met Glu Arg Ser Phe Leu Ser Ala Ala Ala Glu Gln Leu Cys Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 20 25 30 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 35 40 45 Arg Ser Leu Pro Arg Pro His Arg Ser Gln Arg Ser His Leu Cys Phe 50 55 60 Arg Ala Lys Pro Val Phe Leu Leu Ser Thr Ala Asn Ile Leu Thr Val 65 70 75 80 Ile Ile Leu Ser Gln Leu Val Ala Arg Arg Gln Lys Ser Ser Tyr Asn 85 90 95 Tyr Leu Leu Ala Leu Ala Ala Ala Asp Ile Leu Val Leu Phe Phe Ile 100 105 110 Val Phe Val Asp Phe Leu Leu Glu Asp Phe Ile Leu Asn Met Gln Met 115 120 125 Pro Gln Val Pro Asp Lys Ile Ile Glu Val Leu Glu Phe Ser Ser Ile 130 135 140 Hi s Thr Ser Ile Trp Ile Thr Val Pro Leu Thr Ile Asp Arg Tyr Ile 145 150 155 160 Ala Val Cys His Pro Leu Lys Tyr His Thr Val Ser Tyr Pro Ala Arg 165 170 175 Thr Arg Lys Val Ile Val Ser Val Tyr Ile Thr Cys Phe Leu Thr Ser 180 185 190 Ile Pro Tyr Tyr Trp Trp Pro Asn Ile Trp Thr Glu Asp Tyr Ile Ser 195 200 205 Thr Ser Val His His Val Leu Ile Trp Ile His Cys Phe Thr Val Tyr 210 215 220 Leu Val Pro Cys Ser Ile Phe Phe Ile Leu Asn Ser Ile Ile Val Tyr 225 230 235 240 Lys Leu Arg Arg Lys Ser Asn Phe Arg Leu Arg Gly Tyr Ser Thr Gly 245 250 255 Lys Thr Thr Ala Ile Leu Phe Thr Ile Thr Ser Ile Phe Ala Thr Leu 260 265 270 Trp Ala Pro Arg Ile Ile Met Ile Leu Tyr His Leu Tyr Gly Ala Pro 275 280 285 Ile Gln Asn Arg Trp Leu Val His Ile Met Ser Asp Ile Ala Asn Met 290 295 300 Leu Ala Leu Leu Asn Thr Ala Ile Asn Phe Phe Leu Tyr Cys Phe Ile 305 310 315 320 Ser Lys Arg Phe Arg Thr Met Ala Ala Ala Thr Leu Lys Ala Phe Phe 325 330 335 Lys Cys Gln Lys Gln Pro Val Gln Phe Tyr Thr Asn His Asn Phe Ser 340 345 350 Ile Thr Ser Ser Pro Trp Ile Ser Pro Ala Asn Ser His Cys Ile Lys 355 360 365 Met Leu Val Tyr Gln Tyr Asp Lys Asn Gly Lys Pro Ile Lys Val Ser 370 375 380 Pro 385 <210> 23 <211> 1197 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1197) <400> 23 atg gag tcg ggg ctg ctg cgg ccg gcg ccg gtg agc gag gtc atc gtc 48 Met Glu Ser Gly Leu Leu Arg Pro Ala Pro Val Ser Glu Val Ile Val 1 5 10 15 ctg cat tac aac tac acc ggc aag ctc cgc ggt gcg cgc tac cag ccg 96 Leu His Tyr Asn Tyr Thr Gly Lys Leu Arg Gly Ala Arg Tyr Gln Pro 20 25 30 ggt gcc ggc ctg cgc gcc gac gcc gtg gtg tgc ctg gcg gtg tgc gcc 144 Gly Ala Gly Leu Arg Ala Asp Ala Val Val Cys Leu Ala Val Cys Ala 35 40 45 tt c atc gtg cta gag aat cta gcc gtg ttg ttg gtg ctc gga cgc cac 192 Phe Ile Val Leu Glu Asn Leu Ala Val Leu Leu Val Leu Gly Arg His 50 55 60 ccg cgc ttc cac gct ccc atg ttc ctg ctc ctg ggc agc ctc acg ttg 240 Pro Arg Phe His Ala Pro Met Phe Leu Leu Leu Gly Ser Leu Thr Leu 65 70 75 80 tcg gat ctg ctg gca ggc gcc gcc tac gcc gcc aac atc cta ctg tcg 288 Ser Asp Leu Leu Ala Gly Ala Ala Tyr Ala Ala Asn Ile Leu Leu Ser 85 90 95 ggg ccg ctc acg ctg aaa ctg tcc ccc gcg ctc tgg ttc gca cgg gag 336 Gly Pro Leu Thr Leu Lys Leu Ser Pro Ala Leu Trp Phe Ala Arg Glu 100 105 110 gga ggc gtc ttc gtg gca ctc act gcg tcc gtg ctg agc ctc ctg gcc 384 Gly Gly Val Phe Val Ala Leu Thr Ala Ser Val Leu Ser Leu Leu Ala 115 120 125 atc gcg ctg gag cgc agc ctc acc atg gcg cgc agg ggg ccc gcg ccc 432 Ile Ala Leu Glu Arg Ser Leu Thr Met Ala Arg Arg Gly Pro Ala Pro 130 135 140 gtc tcc agt cgg ggg cgc acg ctg gcg atg gca gcc gcg gcc tgg ggc 480 Val Ser Ser Arg Gly Arg Thr Leu Ala Met Ala Ala Ala Ala Trp Gly 145 150 155 160 gtg tcg ctg ctc ctc ggg ctc ctg cca gcg ctg ggc tgg aat tgc ctg 528 Val Ser Leu Leu Leu Gly Leu Leu Pro Ala Leu Gly Trp Asn Cys Leu 165 170 175 ggt cgc ctg gac gct tgc tcc act gtc ttg ccg ctc tac gcc aag gcc 576 Gly Arg Leu Asp Ala Cys Ser Thr Val Leu Pro Leu Tyr Ala Lys Ala 180 185 190 tac gtg ctc ttc tgc gtg ctc gcc ttc gtg ggc atc ctg gcc gct atc 624 Tyr Val Leu Phe Cys Val Leu Ala Phe Val Gly Ile Leu Ala Ala Ile 195 200 205 tgt gca ctc tac gcg cgc atc tac tgc cag gta cgc gcc aac gcg cgg 672 Cys Ala Leu Tyr Ala Arg Ile Tyr Cys Gln Val Arg Ala Asn Ala Arg 210 215 220 cgc ctg ccg gca cgg ccc ggg act gcg ggg acc acc tcg acc cgg gcg 720 Arg Leu Pro Ala Arg Pro Gly Thr Ala Gly Thr Thr Ser Thr Arg Ala 225 230 235 240 cgt cgc aag ccg cgc tcg ctg gcc ttg ctg cgc acg ctc agc gtg gtg 768 Arg Arg Lys Pro Arg Ser Leu Ala Leu Leu Arg Thr Leu Ser Val Val 245 250 255 ctc ctg gcc ttt gtg gca tgt tgg ggc ccc ctc ttc ctg ctg ctg ttg 816 Leu Leu Ala Phe Val Ala Cys Trp Gly Pro Leu Phe Leu Leu Leu Leu 260 265 270 ctc gac gtg gcg tgc ccg gcg cgc acc tgt cct gta ctc ctg cag gcc 864 Leu Asp Val Ala Cys Pro Ala Arg Thr Cys Pro Val Leu Leu Gln Ala 275 280 285 gat ccc ttc ctg gga ctg gcc atg gcc aac tca ctt ctg aac ccc atc 912 Asp Pro Phe Leu Gly Leu Ala Met Ala Asn Ser Leu Leu Asn Pro Ile 290 295 300 atc tac acg ctc acc aac cgc gac ctg cgc cac gcg ctc ctg cgc ctg 960 Ile Tyr Thr Leu Thr Asn Arg Asp Leu Arg His Ala Leu Leu Arg Leu 305 310 315 320 gtc tgc tgc gga cgc cac tcc tgc ggc aga gac ccg agt ggc tcc cag 1008 Val Cys Cys Gly Arg His Ser Cys Gly Arg Asp Pro Ser Gly Ser Gln 325 330 335 cag tcg gcg agc gcg gct gag gct tcc ggg ggc ctg cgc cgc tgc ctg 1056 Gln Ser Ala Ser Ala Ala Glu Ala Ser Gly Gly Leu Arg Arg Cys Leu 340 345 350 ccc ccg ggc ctt gat ggg agc ttc agc ggc tcg gag cgc tca tcg ccc 1104 Pro Pro Gly Leu Asp Gly Ser Phe Ser Gly Ser Glu Arg Ser Ser Pro 355 360 365 cag cgc gac ggg ctg gac acc agc ggc tcc aca ggc agc ccc ggt gca 1152 Gln Arg Asp Gly Leu Asp Thr Ser Gly Ser Thr Gly Ser Pro Gly Ala 370 375 380 ccc aca gcc gcc cgg act ctg gta tca gaa ccg gct gca gac tga 1197 Pro Thr Ala Ala Arg Thr Leu Val Ser Glu Pro Ala Ala Asp 385 390 395 <210> 24 <211> 398 <212> PRT <213> Homo sapiens <400> 24 Met Glu Ser Gly Leu Leu Arg Pro Ala Pro Val Ser Glu Val Ile Val 1 5 10 15 Leu His Tyr Asn Tyr Thr Gly Lys Leu Arg Gly Ala Arg Tyr Gln Pro 20 25 30 Gly Ala Gly Leu Arg Ala Asp Ala Val Val Cys Leu Ala Val Cys Ala 35 40 45 Phe Ile Val Leu Glu Asn Leu Ala Val Leu Leu Val Leu Gly Arg His 50 55 60 Pro Arg Phe His Ala Pro Met Phe Leu Leu Leu Gly Ser Leu Thr Leu 65 70 75 80 Ser Asp Leu Leu Ala Gly Ala Ala Tyr Ala Ala Asn Ile Leu Leu Ser 85 90 95 Gly Pro Leu Thr Leu Lys Leu Ser Pro Ala Leu Trp Phe Ala Arg Glu 100 105 110 Gly Gly Val Phe Val Ala Leu Thr Ala Ser Val Leu Ser Leu Leu Ala 115 120 125 Ile Ala Leu Glu Arg Ser Leu Thr Met Ala Arg Arg Gly Pro Ala Pro 130 135 140 Val Ser Ser Arg Gly Arg Thr Leu Ala Met Ala Ala Ala Ala Trp Gly 145 150 155 160 Val Ser Leu Leu Leu Gly Leu Leu Pro Ala Leu Gly Trp Asn Cys Leu 165 170 175 Gly Arg Leu Asp Ala Cys Ser Thr Val Leu Pro Leu Tyr Ala Lys Ala 180 185 190 Tyr Val Leu Phe Cys Val Leu Ala Phe Val Gly Ile Leu Ala Ala Ile 195 200 205 Cys Ala Leu Tyr Ala Arg Ile Tyr Cys Gln Val Arg Ala Asn Ala Arg 210 215 220 Arg Leu Pro Ala Arg Pro Gly Thr Ala Gly Thr Thr Ser Thr Arg Ala 225 230 235 240 Arg Arg Lys Pro Arg Ser Leu Ala Leu Leu Arg Thr Leu Ser Val Val 245 250 255 Leu Leu Ala Phe Val Ala Cys Trp Gly Pro Leu Phe Leu Leu Leu Leu 260 265 270 Leu Asp Val Ala Cys Pro Ala Arg Thr Cys Pro Val Leu Leu Gln Ala 275 280 285 Asp Pro Phe Leu Gly Leu Ala Met Ala Asn Ser Leu Leu Asn Pro Ile 290 295 300 Ile Tyr Thr Leu Thr Asn Arg Asp Leu Arg His Ala Leu Leu Arg Leu 305 310 315 320 Val Cys Cys Gly Arg His Ser Cys Gly Arg Asp Pro Ser Gly Ser Gln 325 330 335 Gln Ser Ala Ser Ala Ala Glu Ala Ser Gly Gly Leu Arg Arg Cys Leu 340 345 350 Pro Pro Gly Leu Asp Gly Ser Phe Ser Gly Ser Glu Arg Ser Ser Pro 355 360 365 Gln Arg Asp Gly Leu Asp Thr Ser Gly Ser Thr Gly Ser Pro Gly Ala 370 375 380 Pro Thr Ala Ala Arg Thr Leu Val Ser Glu Pro Ala Ala Asp 385 390 395 <210> 25 <211> 1029 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1029) <400> 25 atg caa gcc gtc gac aac ctc acc tct gcg cct ggt aac acc agt ctg 48 Met Gln Ala Val Asp Asn Leu Thr Ser Ala Pro Gly Asn Thr Ser Leu 1 5 10 15 tgc acc aga gac tac aaa atc acc cag gtc ctc ttc cca ctg ctc tac 96 Cys Thr Arg Asp Tyr Lys Ile Thr Gln Val Leu Phe Pro Leu Leu Tyr 20 25 30 act gtc ctg ttt ttt gtt gga ctt atc aca aat ggc ctg gcg atg agg 144 Thr Val Leu Phe Phe Val Gly Leu Ile Thr Asn Gly Leu Ala Met Arg 35 40 45 att ttc ttt caa atc cgg agt aaa tca aac ttt att att ttt ctt aag 192 Ile Phe Phe Gln Ile Arg Ser Lys Ser Asn Phe Ile Ile Phe Leu Lys 50 55 60 aac aca gtc att tct gat ctt ctc atg att ctg act ttt cca ttc aaa 240 Asn Thr Val Ile Ser Asp Leu Leu Met Ile Leu Thr Phe Pro Phe Lys 65 70 75 80 att ctt agt gat gcc aaa ctg gga aca gga cca ctg aga act ttt gtg 288 Ile Leu Ser Asp Ala Lys Leu Gly Thr Gly Pro Leu Arg Thr Phe Val 85 90 95 tgt caa gtt acc tcc gtc ata ttt tat ttc aca atg tat atc agt att 336 Cys Gln Val Thr Ser Val Ile Phe Tyr Phe Thr Met Tyr Ile Ser Ile 100 105 110 tca ttc ctg gga ctg ata act atc gat cgc tac cag aag acc acc agg 384 Ser Phe Leu Gly Leu Ile Thr Ile Asp Arg Tyr Gln Lys Thr Thr Arg 115 120 125 cca ttt aaa aca tcc aac ccc aaa aat ctc ttg ggg gct aag att ctc 432 Pro Phe Lys Thr Ser Asn Pro Lys Asn Leu Leu Gly Ala Lys Ile Leu 130 135 140 tct gtt gtc atc tgg gca ttc atg ttc tta ctc tct ttg cct aac atg 480 Ser Val Val Ile Trp Ala Phe Met Phe Leu Leu Ser Leu Pro Asn Met 145 150 155 160 att ctg acc aac agg cag ccg aga gac aag aat gtg aag aaa tgc tct 528 Ile Leu Thr Asn Arg Gln Pro Arg Asp Lys Asn Val Lys Lys Cys Ser 165 170 175 ttc ctt aaa tca gag ttc ggt cta gtc tgg cat gaa ata gta aat tac 576 Phe Leu Lys Ser Glu Phe Gly Leu Val Trp His Glu Ile Val Asn Tyr 180 185 190 atc tgt caa gtc att ttc tgg att aat ttc tta att gtt att gta tgt 624 Ile Cys Gln Val Ile Phe Trp Ile Asn Phe Leu Ile Val Ile Val Cys 195 200 205 tat aca ctc att aca aaa gaa ctg tac cgg tca tac gta aga acg agg 672 Tyr Thr Leu Ile Thr Lys Glu Leu Tyr Arg Ser Tyr Val Arg Thr Arg 210 215 220 ggt gta ggt aaa gtc ccc agg aaa aag gtg aac gtc aaa gtt ttc att 720 Gly Val Gly Lys Val Pro Arg Lys Lys Val Asn Val Lys Val Phe Ile 225 230 235 240 atc att gct gta ttc ttt att tgt ttt gtt cct ttc cat ttt gcc cga 768 Ile Ile Ala Val Phe Phe Ile Cys Phe Val Pro Phe His Phe Ala Arg 245 250 255 att cct tac acc ctg agc caa acc cgg gat gtc ttt gac tgc act gct 816 Ile Pro Tyr Thr Leu Ser Gln Thr Arg Asp Val Phe Asp Cys Thr Ala 260 265 270 gaa aat act ctg ttc tat gtg aaa gag agc act ctg tgg tta act tcc 864 Glu Asn Thr Leu Phe Tyr Val Lys Glu Ser Thr Leu Trp Leu Thr Ser 275 280 285 tta aat gca tgc ctg gat ccg ttc atc tat ttt ttc ctt tgc aag tcc 912 Leu Asn Ala Cys Leu Asp Pro Phe Ile Tyr Phe Phe Leu Cys Lys Ser 290 295 300 ttc aga aat tcc ttg ata agt atg ctg aag tgc ccc aat tct gca aca 960 Phe Arg Asn Ser Leu Ile Ser Met Leu Lys Cys Pro Asn Ser Ala Thr 305 310 315 320 tct ctg tcc cag gac aat agg aaa aaa gaa cag gat ggt ggt gac cca 1008 Ser Leu Ser Gln Asp Asn Arg Lys Lys Glu Gln Asp Gly Gly Asp Pro 325 330 335 aat gaa gag act cca atg taa 1029 Asn Glu Glu Thr Pro Met 340 <210> 26 <211> 342 <212> PRT <213> Homo sapiens <400> 26 Met Gln Ala Val Asp Asn Leu Thr Ser Ala Pro Gly Asn Thr Ser Leu 1 5 10 15 Cys Thr Arg Asp Tyr Lys Ile Thr Gln Val Leu Phe Pro Leu Leu Tyr 20 25 30 Thr Val Leu Phe Phe Val Gly Leu Ile Thr Asn Gly Leu Ala Met Arg 35 40 45 Ile Phe Phe Gln Ile Arg Ser Lys Ser Asn Phe Ile Ile Phe Leu Lys 50 55 60 Asn Thr Val Ile Ser Asp Leu Leu Met Ile Leu Thr Phe Pro Phe Lys 65 70 75 80 Ile Leu Ser Asp Ala Lys Leu Gly Thr Gly Pro Leu Arg Thr Phe Val 85 90 95 Cys Gln Val Thr Ser Val Ile Phe Tyr Phe Thr Met Tyr Ile Ser Ile 100 105 110 Ser Phe Leu Gly Leu Ile Thr Ile Asp Arg Tyr Gln Lys Thr Thr Arg 115 120 125 Pro Phe Lys Thr Ser Asn Pro Lys Asn Leu Leu Gly Ala Lys Ile Leu 130 135 140 Ser Val Val Ile Trp Ala Phe Met Phe Leu Leu Ser Leu Pro Asn Met 145 150 155 160 Ile Leu Thr Asn Arg Gln Pro Arg Asp Lys Asn Val Lys Lys Cys Ser 165 170 175 Phe Leu Lys Ser Glu Phe Gly Leu Val Trp His Glu Ile Val Asn Tyr 180 185 190 Ile Cys Gln Val Ile Phe Trp Ile Asn Phe Leu Ile Val Ile Val Cys 195 200 205 Tyr Thr Leu Ile Thr Lys Glu Leu Tyr Arg Ser Tyr Val Arg Thr Arg 210 215 220 Gly Val Gly Lys Val Pro Arg Lys Lys Val Asn Val Lys Val Phe Ile 225 230 235 240 Ile Ile Ala Val Phe Phe Ile Cys Phe Val Pro Phe His Phe Ala Arg 245 250 255 Ile Pro Tyr Thr Leu Ser Gln Thr Arg Asp Val Phe Asp Cys Thr Ala 260 265 270 Glu Asn Thr Leu Phe Tyr Val Lys Glu Ser Thr Leu Trp Leu Thr Ser 275 280 285 Leu Asn Ala Cys Leu Asp Pro Phe Ile Tyr Phe Phe Leu Cys Lys Ser 290 295 300 Ph e Arg Asn Ser Leu Ile Ser Met Leu Lys Cys Pro Asn Ser Ala Thr 305 310 315 320 Ser Leu Ser Gln Asp Asn Arg Lys Lys Glu Gln Asp Gly Gly Asp Pro 325 330 335 Asn Glu Glu Thr Pro Met 340 <210> 27 <211> 1260 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1260) <400> 27 atg ctg gca gct gcc ttt gca gac tct aac tcc agc agc atg aat gtg 48 Met Leu Ala Ala Ala Phe Ala Asp Ser Asn Ser Ser Ser Met Asn Val 1 5 10 15 tcc ttt gct cac ctc cac ttt gcc gga ggg tac ctg ccc tct gat tcc 96 S er Phe Ala His Leu His Phe Ala Gly Gly Tyr Leu Pro Ser Asp Ser 20 25 30 cag gac tgg aga acc atc atc ccg gct ctc ttg gtg gct gtc tgc ctg 144 Gln Asp Trp Arg Thr Ile Ile Pro Ala Leu Leu Val Ala Val Cys Leu 35 40 45 gtg ggc ttc gtg gga aac ctg tgt gtg att ggc atc ctc ctt cac aat 192 Val Gly Phe Val Gly Asn Leu Cys Val Ile Gly Ile Leu Leu His Asn 50 55 60 gct tgg aaa gga aag cca tcc atg atc cac tcc ctg att ctg aat ctc 240 Ala Trp Lys Gly Lys Pro Ser Met Ile His Ser Leu Ile Leu Asn Leu 65 70 75 80 agc ctg gct gat ctc tcc ctc ctg ctg ttt tct gca cct atc cga gct 288 Ser Leu Ala Asp Leu Ser Leu Leu Leu Phe Ser Ala Pro Ile Arg Ala 85 90 95 acg gcg tac tcc aaa agt gtt tgg gat cta ggc tgg ttt gtc tgc aag 336 Thr Ala Tyr Ser Lys Ser Val Trp Asp Leu Gly Trp Phe Val Cys Lys 100 105 110 tcc tct gac tgg ttt atc cac aca tgc atg gca gcc aag agc ctg aca 384 Ser Ser Asp Trp Phe Ile His Thr Cys Met Ala Ala Lys Ser Leu Thr 115 120 125 atc gtt gtg gtg gcc aaa gta tgc ttc atg tat gca agt gac cca gcc 432 Ile Val Val Val Ala Lys Val Cys Phe Met Tyr Ala Ser Asp Pro Ala 130 135 140 aag caa gtg agt atc cac aac tac acc atc tgg tca gtg ctg gtg gcc 480 Lys Gln Val Ser Ile His Asn Tyr Thr Ile Trp Ser Val Leu Val Ala 145 150 155 160 atc tgg act gtg gct agc ctg tta ccc ctg ccg gaa tgg ttc ttt agc 528 Ile Trp Thr Val Ala Ser Leu Leu Pro Leu Pro Glu Trp Phe Phe Ser 165 170 175 acc atc agg cat cat gaa ggt gtg gaa atg tgc ctc gtg gat gta cca 576 Thr Ile Arg His His Glu Gly Val Glu Met Cys Leu Val Asp Val Pro 180 185 190 gct gtg gct gaa gag ttt atg tcg atg ttt ggt aag ctc tac cca ctc 624 Ala Val Ala Glu Glu Phe Met Ser Met Phe Gly Lys Leu Tyr Pro Leu 195 200 205 ctg gca ttt ggc ctt cca tta ttt ttt gcc agc ttt tat ttc tgg aga 672 Leu Ala Phe Gly Leu Pro Leu Phe Phe Ala Ser Phe Tyr Phe Trp Arg 210 215 220 gct tat gac caa tgt aaa aaa cga gga act aag act caa aat ctt aga 720 Ala Tyr Asp Gln Cys Lys Lys Arg Gly Thr Lys Thr Gln Asn Leu Arg 225 230 235 240 aac cag ata cgc tca aag caa gtc aca gtg atg ctg ctg agc att gcc 768 Asn Gln Ile Arg Ser Lys Gln Val Thr Val Met Leu Leu Ser Ile Ala 245 250 255 atc atc tct gct ctc ttg tgg ctc ccc gaa tgg gta gct tgg ctg tgg 816 Ile Ile Ser Ala Leu Leu Trp Leu Pro Glu Trp Val Ala Trp Leu Trp 260 265 270 gta tgg cat ctg aag gct gca ggc ccg gcc cca cca caa ggt ttc ata 864 Val Trp His Leu Lys Ala Ala Gly Pro Ala Pro Pro Gln Gly Phe Ile 275 280 285 gcc ctg tct caa gtc ttg atg ttt tcc atc tct tca gca aat cct ctc 912 Ala Leu Ser Gln Val Leu Met Phe Ser Ile Ser Ser Ala Asn Pro Leu 290 295 300 att ttt ctt gtg atg tcg gaa gag ttc agg gaa ggc ttg aaa ggt gta 960 Ile Phe Leu Val Met Ser Glu Glu Phe Arg Glu Gly Leu Lys Gly Val 305 310 315 320 tgg aaa tgg atg ata acc aaa aaa cct cca act gtc tca gag tct cag 1008 Trp Lys Trp Met Ile Thr Lys Lys Pro Pro Thr Val Ser Glu Ser Gln 325 330 335 gaa aca cca gct ggc aac tca gag ggt ctt cct gac aag gtt cca tct 1056 Glu Thr Pro Ala Gly Asn Ser Glu Gly Leu Pro Asp Lys Val Pro Ser 340 345 350 cca gaa tcc cca gca tcc ata cca gaa aaa gag aaa ccc agc tct ccc 1104 Pro Glu Ser Pro Ala Ser Ile Pro Glu Lys Glu Lys Pro Ser Ser Pro 355 360 365 tcc tct ggc aaa ggg aaa act gag aag gca gag att ccc atc ctt cct 1152 Ser Ser Gly Lys Gly Lys Thr Glu Lys Ala Glu Ile Pro Ile Leu Pro 370 375 380 gac gta gag cag ttt tgg cat gag agg gac aca gtc cct tct gta cag 1200 Asp Val Glu Gln Phe Trp His Glu Arg Asp Thr Val Pro Ser Val Gln 385 390 395 400 gac aat gac cct atc ccc tgg gaa cat gaa gat caa gag aca ggg gaa 1248 Asp Asn Asp Pro Ile Pro Trp Glu His Glu Asp Gln Glu Thr Gly Glu 405 410 415 ggt gtt aaa tag 1260 Gly Val Lys 420 <210> 28 <211> 419 <212> PRT <213> Homo sapiens <400> 28 Met Leu Ala Ala Ala Phe Ala Asp Ser Asn Ser Ser Ser Met Asn Val 1 5 10 15 Ser Phe Ala His Leu His Phe Ala Gly Gly Tyr Leu Pro Ser Asp Ser 20 25 30 Gln Asp Trp Arg Thr Ile Ile Pro Ala Leu Leu Val Ala Val Cys Leu 35 40 45 Val Gly Phe Val Gly Asn Leu Cys Val Ile Gly Ile Leu Leu His Asn 50 55 60 Ala Trp Lys Gly Lys Pro Ser Met Ile His Ser Leu Ile Leu Asn Leu 65 70 75 80 Ser Leu Ala Asp Leu Ser Leu Leu Leu Phe Ser Ala Pro Ile Arg Ala 85 90 95 Thr Ala Tyr Ser Lys Ser Val Trp Asp Leu Gly Trp Phe Val Cys Lys 100 105 110 Ser Ser Asp Trp Phe Ile His Thr Cys Met Ala Ala Lys Ser Leu Thr 115 120 125 Ile Val Val Val Ala Lys Val Cys Phe Met Tyr Ala Ser Asp Pro Ala 130 135 140 Lys Gln Val Ser Ile His Asn Tyr Thr Ile Trp Ser Val Leu Val Ala 145 150 155 160 Ile Trp Thr Val Ala Ser Leu Leu Pro Leu Pro Glu Trp Phe Phe Ser 165 170 175 Thr Ile Arg His His Glu Gly Val Glu Met Cys Leu Val Asp Val Pro 180 185 190 Ala Val Ala Glu Glu Phe Met Ser Met Phe Gly Lys Leu Tyr Pro Leu 195 200 205 Leu Ala Phe Gly Leu Pro Leu Phe Phe Ala Ser Phe Tyr Phe Trp Arg 210 215 220 Ala Tyr Asp Gln Cys Lys Lys Arg Gly Thr Lys Thr Gln Asn Leu Arg 225 230 235 240 Asn Gln Ile Arg Ser Lys Gln Val Thr Val Met Leu Leu Ser Ile Ala 245 250 255 Ile Ile Ser Ala Leu Leu Trp Leu Pro Glu Trp Val Ala Trp Leu Trp 260 265 270 Val Trp His Leu Lys Ala Ala Gly Pro Ala Pro Pro Gln Gly Phe Ile 275 280 285 Ala Leu Ser Gln Val Leu Met Phe Ser Ile Ser Ser Ala Asn Pro Leu 290 295 300 Ile Phe Leu Val Met Ser Glu Glu Phe Arg Glu Gly Leu Lys Gly Val 305 310 315 320 Trp Lys Trp Met Ile Thr Lys Lys Pro Pro Thr Val Ser Glu Ser Gln 325 330 335 Glu Thr Pro Ala Gly Asn Ser Glu Gly Leu Pro Asp Lys Val Pro Ser 340 345 350 Pro Glu Ser Pro Ala Ser Ile Pro Glu Lys Glu Lys Pro Ser Ser Pro 355 360 365 Ser Ser Gly Lys Gly Lys Thr Glu Lys Ala Glu Ile Pro Ile Leu Pro 370 375 380 Asp Val Glu Gln Phe Trp His Glu Arg Asp Thr Val Pro Ser Val Gln 385 390 395 400 Asp Asn Asp Pro Ile Pro Trp Glu His Glu Asp Gln Glu Thr Gly Glu 405 410 415 Gly Val Lys <210> 29 <211> 1356 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1356) <400> 29 atg gag tcc tca ccc atc ccc cag tca tca ggg aac tct tcc act ttg 48 Met Glu Ser Ser Pro Ile Pro Gln Ser Ser Gly Asn Ser Ser Thr Leu 1 5 10 15 ggg agg gtc cct caa acc cca ggt ccc tct act gcc agt ggg gtc ccg 96 Gly Arg Val Pro Gln Thr Pro Gly Pro Ser Thr Ala Ser Gly Val Pro 20 25 30 gag gtg ggg cta cgg gat gtt gct tcg gaa tct gtg gcc ctc ttc ttc 144 Glu Val Gly Leu Arg Asp Val Ala Ser Glu Ser Val Ala Leu Phe Phe 35 40 45 atg ctc ctg ctg gac ttg act gct gtg gct ggc aat gcc gct gtg atg 192 Met Leu Leu Leu Asp Leu Thr Ala Val Ala Gly Asn Ala Ala Val Met 50 55 60 gcc gtg atc gcc aag acg cct gcc ctc cga aaa ttt gtc ttc gtc ttc 240 Ala Val Ile Ala Lys Thr Pro Ala Leu Arg Lys Phe Val Phe Val Phe 65 70 75 80 cac ctc tgc ctg gtg gac ctg ctg gct gcc ctg acc ctc atg ccc ctg 288 His Leu Cys Leu Val Asp Leu Leu Ala Ala Leu Thr Leu Met Pro Leu 85 90 95 gcc atg ctc tcc agc tct gcc ctc ttt gac cac gcc ctc ttt ggg gag 336 Ala Met Leu Ser Ser Ser Ala Leu Phe Asp His Ala Leu Phe Gly Glu 100 105 110 gtg gcc tgc cgc ctc tac ttg ttt ctg agc gtg tgc ttt gtc agc ctg 384 Val Ala Cys Arg Leu Tyr Leu Phe Leu Ser Val Cys Phe Val Ser Leu 115 120 125 gcc atc ctc tcg gtg tca gcc atc aat gtg gag cgc tac tat tac gta 432 Ala Ile Leu Ser Val Ser Ala Ile Asn Val Glu Arg Tyr Tyr Tyr Val 130 135 140 gtc cac ccc atg cgc tac gag gtg cgc atg acg ctg ggg ctg gtg gcc 480 Val His Pro Met Arg Tyr Glu Val Arg Met Thr Leu Gly Leu Val Ala 145 150 155 160 tct gtg ctg gtg ggt gtg tgg gtg aag gcc ttg gcc atg gct tct gtg 528 Ser Val Leu Val Gly Val Trp Val Lys Ala Leu Ala Met Ala Ser Val 165 170 175 cca gtg ttg gga agg gtc tcc tgg gag gaa gga gct ccc agt gtc ccc 576 Pro Val Leu Gly Arg Val Ser Trp Glu Glu Gly Ala Pro Ser Val Pro 180 185 190 cca ggc tgt tca ctc cag tgg agc cac agt gcc tac tgc cag ctt ttt 624 Pro Gly Cys Ser Leu Gln Trp Ser His Ser Ala Tyr Cys Gln Leu Phe 195 200 205 gtg gtg gtc ttt gct gtc ctt tac ttt ctg ttg ccc ctg ctc ctc ata 672 Val Val Val Phe Ala Val Leu Tyr Phe Leu Leu Pro Leu Leu Leu Ile 210 215 220 ctt gtg gtc tac tgc agc atg ttc cga gtg gcc cgc gtg gct gcc atg 720 Leu Val Val Tyr Cys Ser Met Phe Arg Val Ala Arg Val Ala Ala Met 225 230 235 240 c ag cac ggg ccg ctg ccc acg tgg atg gag aca ccc cgg caa cgc tcc 768 Gln His Gly Pro Leu Pro Thr Trp Met Glu Thr Pro Arg Gln Arg Ser 245 250 255 gaa tct ctc agc agc cgc tcc acg atg gtc acc agc tcg ggg gcc ccc 816 Glu Ser Leu Ser Ser Arg Ser Thr Met Val Thr Ser Ser Gly Ala Pro 260 265 270 cag acc acc cca cac cgg acg ttt ggg gga ggg aaa gca gca gtg gtt 864 Gln Thr Thr Pro His Arg Thr Phe Gly Gly Gly Lys Ala Ala Val Val 275 280 285 ctc ctg gct gtg ggg gga cag ttc ctg ctc tgt tgg ttg ccc tac ttc 912 Leu Leu Ala Val Gly Gly Gln Phe Leu Leu Cys Trp Leu Pro Tyr Phe 290 295 300 tct ttc cac ctc tat gtt gcc ctg agt gct cag ccc att tca act ggg 960 Ser Phe His Leu Tyr Val Ala Leu Ser Ala Gln Pro Ile Ser Thr Gly 305 310 315 320 cag gtg gag agt gtg gtc acc tgg att ggc tac ttt tgc ttc act tcc 1008 Gln Val Glu Ser Val Val Thr Trp Ile Gly Tyr Phe Cys Phe Thr Ser 325 330 335 aac cct ttc ttc tat gga tgt ctc aac cgg cag atc cgg ggg gag ctc 1056 Asn Pro Phe Phe Tyr Gly Cys Leu Asn Arg Gln Ile Arg Gly Glu Leu 340 345 350 agc aag cag ttt gtc tgc ttc ttc aag cca gct cca gag gag gag ctg 1104 Ser Lys Gln Phe Val Cys Phe Phe Lys Pro Ala Pro Glu Glu Glu Leu 355 360 365 agg ctg cct agc cgg gag ggc tcc att gag gag aac ttc ctg cag ttc 1152 Arg Leu Pro Ser Arg Glu Gly Ser Ile Glu Glu Asn Phe Leu Gln Phe 370 375 380 ctt cag ggg act ggc tgt cct tct gag tcc tgg gtt tcc cga ccc cta 1200 Leu Gln Gly Thr Gly Cys Pro Ser Glu Ser Trp Val Ser Arg Pro Leu 385 390 395 400 ccc agc ccc aag cag gag cca cct gct gtt gac ttt cga atc cca ggc 1248 Pro Ser Pro Lys Gln Glu Pro Pro Ala Val Asp Phe Arg Ile Pro Gly 405 410 415 cag ata gct gag gag acc tct gag ttc ctg gag cag caa ctc acc agc 1296 Gln Ile Ala Glu Glu Thr Ser Glu Phe Leu Glu Gln Gln Leu Thr Ser 420 425 430 gac atc atc atg tca gac agc tac ctc cgt cct gcc gcc tca ccc cgg 1344 Asp Ile Ile Met Ser Asp Ser Tyr Leu Arg Pro Ala Ala Ser Pro Arg 435 440 445 ctg gag tca tga 1356 Leu Glu Ser 450 <210> 30 <211> 451 <212> PRT <213> Homo sapiens <400> 30 Met Glu Ser Ser Pro Ile Pro Gln Ser Ser Gly Asn Ser Ser Thr Leu 1 5 10 15 Gly Arg Val Pro Gln Thr Pro Gly Pro Ser Thr Ala Ser Gly Val Pro 20 25 30 Glu Val Gly Leu Arg Asp Val Ala Ser Glu Ser Val Ala Leu Phe Phe 35 40 45 Met Leu Leu Leu Asp Leu Thr Ala Val Ala Gly Asn Ala Ala Val Met 50 55 60 Al a Val Ile Ala Lys Thr Pro Ala Leu Arg Lys Phe Val Phe Val Phe 65 70 75 80 His Leu Cys Leu Val Asp Leu Leu Ala Ala Leu Thr Leu Met Pro Leu 85 90 95 Ala Met Leu Ser Ser Ser Ala Leu Phe Asp His Ala Leu Phe Gly Glu 100 105 110 Val Ala Cys Arg Leu Tyr Leu Phe Leu Ser Val Cys Phe Val Ser Leu 115 120 125 Ala Ile Leu Ser Val Ser Ala Ile Asn Val Glu Arg Tyr Tyr Tyr Val 130 135 140 Val His Pro Met Arg Tyr Glu Val Arg Met Thr Leu Gly Leu Val Ala 145 150 155 160 Ser Val Leu Val Gly Val Trp Val Lys Ala Leu Ala Met Ala Ser Val 165 170 175 Pro Val Leu Gly Arg Val Ser Trp Glu Glu Gly Ala Pro Ser Val Pro 180 185 190 Pro Gly Cys Ser Leu Gln Trp Ser His Ser Ala Tyr Cys Gln Leu Phe 195 200 205 Val Val Val Phe Ala Val Leu Tyr Phe Leu Leu Pro Leu Leu Leu Ile 210 215 220 Leu Val Val Tyr Cys Ser Met Phe Arg Val Ala Arg Val Ala Ala Met 225 230 235 240 Gln His Gly Pro Leu Pro Thr Trp Met Glu Thr Pro Arg Gln Arg Ser 245 250 255 Glu Ser Leu Ser Ser Arg Ser Thr Met Val Thr Ser Ser Gly Ala Pro 260 265 270 Gln Thr Thr Pro His Arg Thr Phe Gly Gly Gly Lys Ala Ala Val Val 275 280 285 Leu Leu Ala Val Gly Gly Gln Phe Leu Leu Cys Trp Leu Pro Tyr Phe 290 295 300 Ser Phe His Leu Tyr Val Ala Leu Ser Ala Gln Pro Ile Ser Thr Gly 305 310 315 320 Gln Val Glu Ser Val Val Thr Trp Ile Gly Tyr Phe Cys Phe Thr Ser 325 330 335 Asn Pro Phe Phe Tyr Gly Cys Leu Asn Arg Gln Ile Arg Gly Glu Leu 340 345 350 Ser Lys Gln Phe Val Cys Phe Phe Lys Pro Ala Pro Glu Glu Glu Leu 355 360 365 Arg Leu Pro Ser Arg Glu Gly Ser Ile Glu Glu Asn Phe Leu Gln Phe 370 375 380 Leu Gln Gly Thr Gly Cys Pro Ser Glu Ser Trp Val Ser Arg Pro Leu 385 390 395 400 Pro Ser Pro Lys Gln Glu Pro Pro Ala Val Asp Phe Arg Ile Pro Gly 405 410 415 Gln Ile Ala Glu Glu Thr Ser Glu Phe Leu Glu Gln Gln Leu Thr Ser 420 425 430 Asp Ile Ile Met Ser Asp Ser Tyr Leu Arg Pro Ala Ala Ser Pro Arg 435 440 445 Leu Glu Ser 450 <210> 31 <211> 1251 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1251) <400> 31 atg ggc acc acc ata tct gga gat aac att gga aaa aat ttc act ttt 48 Met Gly Thr Thr Ile Ser Gly Asp Asn Ile Gly Lys Asn Phe Thr Phe 1 5 10 15 tct atg aga att aat gat acc agc aat gaa gtc act ggg aga gtg ttg 96 Ser Met Arg Ile Asn Asp Thr Ser Asn Glu Val Thr Gly Arg Val Leu 20 25 30 atc agc aga gat gaa ctt cgg aag gtg cct tcc cct tct cag gtc atc 144 Ile Ser Arg Asp Glu Leu Arg Lys Val Pro Ser Pro Ser Gln Val Ile 35 40 45 agc att gca ttt cca act att ggg gct att ttg gaa gcc agt ctt ttg 192 Ser Ile Ala Phe Pro Thr Ile Gly Ala Ile Leu Glu Ala Ser Leu Leu 50 55 60 gaa aat gtt act gta aat ggg ctt gtc ctg tct gcc att ttg ccc aag 240 Glu Asn Val Thr Val Asn Gly Leu Val Leu Ser Ala Ile Leu Pro Lys 65 70 75 80 gaa ctt aaa aga atc tca ctg att ttt gaa aag atc agc aag tca gag 288 Glu Leu Lys Arg Ile Ser Leu Ile Phe Glu Lys Ile Ser Lys Ser Glu 85 90 95 gag agg agg aca cag tgt gtt ggc tgg cac tct gtg gag aac aga tgg 336 Glu Arg Arg Thr Gln Cys Val Gly Trp His Ser Val Glu Asn Arg Trp 100 105 110 gac cag cag gcc tgc aaa atg att caa gaa aac tcc cag caa gct gtt 384 Asp Gln Gln Ala Cys Lys Met Ile Gln Glu Asn Ser Gln Gln Ala Val 115 120 125 tgc aaa tgt agg cca agc aaa ttg ttt acc tct ttc tca att ctt atg 432 Cys Lys Cys Arg Pro Ser Lys Leu Phe Thr Ser Phe Ser Ile Leu Met 130 135 140 tca cct cac atc tta gag agt ctg att ctg act tac atc aca tat gta 480 Ser Pro His Ile Leu Glu Ser Leu Ile Leu Thr Tyr Ile Thr Tyr Val 145 150 155 160 ggc ctg ggc att tct att tgc agc ctg atc ctt tgc ttg tcc att gag 528 Gly Leu Gly Ile Ser Ile Cys Ser Leu Ile Leu Cys Leu Ser Ile Glu 165 170 175 gtc cta gtc tgg agc caa gtg aca aag aca gag atc acc tat tta cgc 576 Val Leu Val Trp Ser Gln Val Thr Lys Thr Glu Ile Thr Tyr Leu Arg 180 185 190 cat gtg tgc att gtt aac att gca gcc act ttg ctg atg gca gat gtg 624 His Val Cys Ile Val Asn Ile Ala Ala Thr Leu Leu Met Ala Asp Val 195 200 205 tgg ttc att gtg gct tcc ttt ctt agt ggc cca ata aca cac cac aag 672 Trp Phe Ile Val Ala Ser Phe Leu Ser Gly Pro Ile Thr His His Lys 210 215 220 gga tgt gtg gca gcc aca ttt ttt gtt cat ttc ttt tac ctt tct gta 720 Gly Cys Val Ala Ala Thr Phe Phe Val His Phe Phe Tyr Leu Ser Val 225 230 235 240 ttt ttc tgg atg ctt gcc aag gca ctc ctt atc ctc tat gga atc atg 768 Phe Phe Trp Met Leu Ala Lys Ala Leu Leu Ile Leu Tyr Gly Ile Met 245 250 255 att gtt ttc cat acc ttg ccc aag tca gtc ctg gtg gca tct ctg ttt 816 Ile Val Phe His Thr Leu Pro Lys Ser Val Leu Val Ala Ser Leu Phe 260 265 270 tca gtg ggc tat gga tgc cct ttg gcc att gct gcc atc act gtt gct 864 Ser Val Gly Tyr Gly Cys Pro Leu Ala Ile Ala Ala Ile Thr Val Ala 275 280 285 gcc act gaa cct ggc aaa ggc tat cta cga cct gag atc tgc tgg ctc 912 Ala Thr Glu Pro Gly Lys Gly Tyr Leu Arg Pro Glu Ile Cys Trp Leu 290 295 300 aac tgg gac atg acc aaa gcc ctc ctg gcc ttc gtg atc cca gct ttg 960 Asn Trp Asp Met Thr Lys Ala Leu Leu Ala Phe Val Ile Pro Ala Leu 305 310 315 320 gcc atc gtg gta gta aac ctg atc aca gtc aca ctg gtg att gtc aag 1008 Ala Ile Val Val Val Asn Leu Ile Thr Val Thr Leu Val Ile Val Lys 325 330 335 acc cag cga gct gcc att ggc aat tcc atg ttc cag gaa gtg aga gcc 1056 Thr Gln Arg Ala Ala Ile Gly Asn Ser Met Phe Gln Glu Val Arg Ala 340 345 350 att gtg aga atc agc aag aac atc gcc atc ctc aca cca ctt ctg gga 1104 Ile Val Arg Ile Ser Lys Asn Ile Ala Ile Leu Thr Pro Leu Leu Gly 355 360 365 ctg acc tgg gga ttt gga gta gcc act gtc atc gat gac aga tcc ctg 1152 Leu Thr Trp Gly Phe Gly Val Ala Thr Val Ile Asp Asp Arg Ser Leu 370 375 380 gcc ttc cac att atc ttc tcc ctg ctc aat gca ttc cag gta agt cca 1200 Ala Phe His Ile Ile Phe Ser Leu Leu Asn Ala Phe Gln Val Ser Pro 385 390 395 400 ga t gct tct gac caa gtg caa agt gag aga att cat gaa gat gtt ctg 1248 Asp Ala Ser Asp Gln Val Gln Ser Glu Arg Ile His Glu Asp Val Leu 405 410 415 tga 1251 <210> 32 <211> 416 <212> PRT <213> Homo sapiens <400> 32 Met Gly Thr Thr Ile Ser Gly Asp Asn Ile Gly Lys Asn Phe Thr Phe 1 5 10 15 Ser Met Arg Ile Asn Asp Thr Ser Asn Glu Val Thr Gly Arg Val Leu 20 25 30 Ile Ser Arg Asp Glu Leu Arg Lys Val Pro Ser Pro Ser Gln Val Ile 35 40 45 Ser Ile Ala Phe Pro Thr Ile Gly Ala Ile Leu Glu Ala Ser Leu Leu 50 55 60 Glu Asn Val Thr Val Asn Gly Leu Val Leu Ser Ala Ile Leu Pro Lys 65 70 75 80 Glu Leu Lys Arg Ile Ser Leu Ile Phe Glu Lys Ile Ser Lys Ser Glu 85 90 95 Glu Arg Arg Thr Gln Cys Val Gly Trp His Ser Val Glu Asn Arg Trp 100 105 110 Asp Gln Gln Ala Cys Lys Met Ile Gln Glu Asn Ser Gln Gln Ala Val 115 120 125 Cys Lys Cys Arg Pro Ser Lys Leu Phe Thr Ser Phe Ser Ile Leu Met 130 135 140 Ser Pro His Ile Leu Glu Ser Leu Ile Leu Thr Tyr Ile Thr Tyr Val 145 150 155 160 Gly Leu Gly Ile Ser Ile Cys Ser Leu Ile Leu Cys Leu Ser Ile Glu 165 170 175 Val Leu Val Trp Ser Gln Val Thr Lys Thr Glu Ile Thr Tyr Leu Arg 180 185 190 His Val Cys Ile Val Asn Ile Ala Ala Thr Leu Leu Met Ala Asp Val 195 200 205 Trp Phe Ile Val Ala Ser Phe Leu Ser Gly Pro Ile Thr His His Lys 210 215 220 Gly Cys Val Ala Ala Thr Phe Phe Val His Phe Phe Tyr Leu Ser Val 225 230 235 240 Phe Phe Trp Met Leu Ala Lys Ala Leu Leu Ile Leu Tyr Gly Ile Met 245 250 255 Ile Val Phe His Thr Leu Pro Lys Ser Val Leu Val Ala Ser Leu Phe 260 265 270 Ser Val Gly Tyr Gly Cys Pro Leu Ala Ile Ala Ala Ile Thr Val Ala 275 280 285 Ala Thr Glu Pro Gly Lys Gly Tyr Leu Arg Pro Glu Ile Cys Trp Leu 290 295 300 Asn Trp Asp Met Thr Lys Ala Leu Leu Ala Phe Val Ile Pro Ala Leu 305 310 315 320 Ala Ile Val Val Val Asn Leu Ile Thr Val Thr Leu Val Ile Val Lys 325 330 335 Thr Gln Arg Ala Ala Ile Gly Asn Ser Met Phe Gln Glu Val Arg Ala 340 345 350 Ile Val Arg Ile Ser Lys Asn Ile Ala Ile Leu Thr Pro Leu Leu Gly 355 360 365 Leu Thr Trp Gly Phe Gly Val Ala Thr Val Ile Asp Asp Arg Ser Leu 370 375 380 Ala Phe His Ile Ile Phe Ser Leu Leu Asn Ala Phe Gln Val Ser Pro 385 390 395 400 Asp Ala Ser Asp Gln Val Gln Ser Glu Arg Ile His Glu Asp Val Leu 405 410 415 <210> 33 <211> 1026 <212> DNA <213> Homo sapiens <220> <22 1> CDS <222> (1)..(1026) <400> 33 atg gag tcc tca ccc atc ccc cag tca tca ggg aac tct tcc act ttg 48 Met Glu Ser Ser Pro Ile Pro Gln Ser Ser Gly Asn Ser Ser Thr Leu 1 5 10 15 ggg agg gtc cct caa acc cca ggt ccc tct act gcc agt ggg gtc ccg 96 Gly Arg Val Pro Gln Thr Pro Gly Pro Ser Thr Ala Ser Gly Val Pro 20 25 30 gag gtg ggg cta cgg gat gtt gct tcg gaa tct gtg gcc ctc ttc ttc 144 Glu Val Gly Leu Arg Asp Val Ala Ser Glu Ser Val Ala Leu Phe Phe 35 40 45 atg ctc ctg ctg gac ttg act gct gtg gct ggc aat gcc gct gtg atg 192 Met Leu Leu Leu Asp Leu Thr Ala Val Ala Gly Asn Ala Ala Val Met 50 55 60 gcc gtg atc gcc aag acg cct gcc ctc cga aaa ttt gtc ttc gtc ttc 240 Ala Val Ile Ala Lys Thr Pro Ala Leu Arg Lys Phe Val Phe Val Phe 65 70 75 80 cac ctc tgc ctg gtg gac ctg ctg gct gcc ctg acc ctc atg ccc ctg 288 His Leu Cys Leu Val Asp Leu Leu Ala Ala Leu Thr Leu Met Pro Leu 85 90 95 gcc atg ctc tcc agc tct gcc ctc ttt gac cac gcc ctc ttt ggg gag 336 Ala Met Leu Ser Ser Ser Ala Leu Phe Asp His Ala Leu Phe Gly Glu 100 105 110 gtg gcc tgc cgc ctc tac ttg ttt ctg agc gtg tgc ttt gtc agc ctg 384 Val Ala Cys Arg Leu Tyr Leu Phe Leu Ser Val Cys Phe Val Ser Leu 115 120 125 gcc atc ctc tcg gtg tca gcc atc aat gtg gag cgc tac tat tac gta 432 Ala Ile Leu Ser Val Ser Ala Ile Asn Val Glu Arg Tyr Tyr Tyr Val 130 135 140 gtc cac ccc atg cgc tac gag gtg cgc atg acg ctg ggg ctg gtg gcc 480 Val His Pro Met Arg Tyr Glu Val Arg Met Thr Leu Gly Leu Val Ala 145 150 155 160 tct gtg ctg gtg ggt gtg tgg gtg aag gcc ttg gcc atg gct tct gtg 528 Ser Val Leu Val Gly Val Trp Val Lys Ala Leu Ala Met Ala Ser Val 165 170 175 cca gtg ttg gga agg gtc tcc tgg gag gaa gga gct ccc agt gtc ccc 576 Pro Val Leu Gly Arg Val Ser Trp Glu Glu Gly Ala Pro Ser Val Pro 180 185 190 cca ggc tgt tca ctc cag tgg agc cac agt gcc tac tgc cag ctt ttt 624 Pro Gly Cys Ser Leu Gln Trp Ser His Ser Ala Tyr Cys Gln Leu Phe 195 200 205 gtg gtg gtc ttt gct gtc ctt tac ttt ctg ttg ccc ctg ctc ctc ata 672 Val Val Val Phe Ala Val Leu Tyr Phe Leu Leu Pro Leu Leu Leu Ile 210 215 220 ctt gtg gtc tac tgc agc atg ttc cga gtg gcc cgc gtg gct gcc atg 720 Leu Val Val Tyr Cys Ser Met Phe Arg Val Ala Arg Val Ala Ala Met 225 230 235 240 cag cac ggg ccg ctg ccc acg tgg atg gag aca ccc cgg caa cgc tcc 768 Gln His Gly Pro Leu Pro Thr Trp Met Glu Thr Pro Arg Gln Arg Ser 245 250 255 gaa tct ctc agc agc cgc tcc acg atg gtc acc agc tcg ggg gcc ccc 816 Glu Ser Leu Ser Ser Arg Ser Thr Met Val Thr Ser Ser Gly Ala Pro 260 265 270 cag acc acc cca cac cgg acg ttt ggg gga ggg aaa gca gca gtg gtt 864 Gln Thr Thr Pro His Arg Thr Phe Gly Gly Gly Lys Ala Ala Val Val 275 280 285 ctc ctg gct gtg ggg gga cag ttc ctg cta tgt tnn nnn nnn nnn nnn 912 Leu Leu Ala Val Gly Gly Gln Phe Leu Leu Cys Xaa Xaa Xaa Xaa Xaa 290 295 300 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 960 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 305 310 315 320 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nna cac cgg nac 1008 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Arg Xaa 325 330 335 gtt atg ggt gga gtg taa 1026 Va l Met Gly Gly Val 340 <210> 34 <211> 341 <212> PRT <213> Homo sapiens <400> 34 Met Glu Ser Ser Pro Ile Pro Gln Ser Ser Gly Asn Ser Ser Thr Leu 1 5 10 15 Gly Arg Val Pro Gln Thr Pro Gly Pro Ser Thr Ala Ser Gly Val Pro 20 25 30 Glu Val Gly Leu Arg Asp Val Ala Ser Glu Ser Val Ala Leu Phe Phe 35 40 45 Me t Leu Leu Leu Asp Leu Thr Ala Val Ala Gly Asn Ala Ala Val Met 50 55 60 Ala Val Ile Ala Lys Thr Pro Ala Leu Arg Lys Phe Val Phe Val Phe 65 70 75 80 His Leu Cys Leu Val Asp Leu Leu Ala Ala Leu Thr Leu Met Pro Leu 85 90 95 Ala Met Leu Ser Ser Ser Ala Leu Phe Asp His Ala Leu Phe Gly Glu 100 105 110 Val Ala Cys Arg Leu Tyr Leu Phe Leu Ser Val Cys Phe Val Ser Leu 115 120 125 Ala Ile Leu Ser Val Ser Ala Ile Asn Val Glu Arg Tyr Tyr Tyr Val 130 135 140 Val His Pro Met Arg Tyr Glu Val Arg Met Thr Leu Gly Leu Val Ala 145 150 155 160 Ser Val Leu Val Gly Val Trp Val Lys Ala Leu Ala Met Ala Ser Val 165 170 175 Pro Val Leu Gly Arg Val Ser Trp Glu Glu Gly Ala Pro Ser Val Pro 180 185 190 Pro Gly Cys Ser Leu Gln Trp Ser His Ser Ala Tyr Cys Gln Leu Phe 195 200 205 Val Val Val Phe Ala Val Leu Tyr Phe Leu Leu Pro Leu Leu Leu Ile 210 215 220 Leu Val Val Tyr Cys Ser Met Phe Arg Val Ala Arg Val Ala Ala Met 225 230 235 240 Gln His Gly Pro Leu Pro Thr Trp Met Glu Thr Pro Arg Gln Arg Ser 245 250 255 Glu Ser Leu Ser Ser Arg Ser Thr Met Val Thr Ser Ser Gly Ala Pro 260 265 270 Gln Thr Thr Pro His Arg Thr Phe Gly Gly Gly Lys Ala Ala Val Val 275 280 285 Leu Leu Ala Val Gly Gly Gln Phe Leu Leu Cys Xaa Xaa Xaa Xaa Xaa 290 295 300 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 305 310 315 320 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Arg Xaa 325 330 335 Val Met Gly Gly Val 340 <210> 35 <211> 1125 <212> DNA <213> Homo sapiens < 220> <221> CDS <222> (1)..(1125) <400> 35 atg ccc aca ctc aat act tct gcc tct cca ccc aca ttc ttc tgg gcc 48 Met Pro Thr Leu Asn Thr Ser Ala Ser Pro Pro Thr Phe Phe Trp Ala 1 5 10 15 aat gcc tcc gga ggc agt gtg ctg agt gct gat gat gct ccg atg cct 96 Asn Ala Ser Gly Gly Ser Val Leu Ser Ala Asp Asp Ala Pro Met Pro 20 25 30 gtc aaa ttc cta gcc ctg agg ctc atg gtt gcc ctg gcc tat ggg ctt 144 Val Lys Phe Leu Ala Leu Arg Leu Met Val Ala Leu Ala Tyr Gly Leu 35 40 45 gtg ggg gcc att ggc ttg ctg gga aat ttg gcg gtg ctg tgg gta ctg 192 Val Gly Ala Ile Gly Leu Leu Gly Asn Leu Ala Val Leu Trp Val Leu 50 55 60 agt aac tgt gcc cgg aga gcc cct ggc cca cct tca gac acc ttc gtc 240 Ser Asn Cys Ala Arg Arg Ala Pro Gly Pro Pro Ser Asp Thr Phe Val 65 70 75 80 ttc aac ctg gct ctg gcg gac ctg gga ctg gca ctc act ctc ccc ttt 288 Phe Asn Leu Ala Leu Ala Asp Leu Gly Leu Ala Leu Thr Leu Pro Phe 85 90 95 tgg gca gcc gag tcg gca ctg gac ttt cac tgg ccc ttc gga ggt gcc 336 Trp Ala Ala Glu Ser Ala Leu Asp Phe His Trp Pro Phe Gly Gly Ala 100 105 110 ctc tgc aag atg gtt ctg acg gcc act gtc ctc aac gtc tat gcc agc 384 Leu Cys Lys Met Val Leu Thr Ala Thr Val Leu Asn Val Tyr Ala Ser 115 120 125 atc ttc ctc atc aca gcg ctg agc gtt gct cgc tac tgg gtg gtg gcc 432 Ile Phe Leu Ile Thr Ala Leu Ser Val Ala Arg Tyr Trp Val Val Ala 130 135 140 atg gct gcg ggg cca ggc acc cac ctc tca ctc ttc tgg gcc cga ata 480 Met Ala Ala Gly Pro Gly Thr His Leu Ser Leu Phe Trp Ala Arg Ile 145 150 155 160 gcc acc ctg gca gtg tgg gcg gcg gct gcc ctg gtg acg gtg ccc aca 528 Ala Thr Leu Ala Val Trp Ala Ala Ala Ala Leu Val Thr Val Pro Thr 165 170 175 gct gtc ttc ggg gtg gag ggt gag gtg tgt ggt gtg cgc ctt tgc ctg 576 Ala Val Phe Gly Val Glu Gly Glu Val Cys Gly Val Arg Leu Cys Leu 180 185 190 ctg cgt ttc ccc agc agg tac tgg ctg ggg gcc tac cag ctg cag agg 624 Leu Arg Phe Pro Ser Arg Tyr Trp Leu Gly Ala Tyr Gln Leu Gln Arg 195 200 205 gtg gtg ctg gct ttc atg gtg ccc ttg ggc gtc atc acc acc agc tac 672 Val Val Leu Ala Phe Met Val Pro Leu Gly Val Ile Thr Thr Ser Tyr 210 215 220 ctg ctg ctg ctg gcc ttc ctg cag cgg cgg caa cgg cgg cgg cag gac 720 Leu Leu Leu Leu Ala Phe Leu Gln Arg Arg Gln Arg Arg Arg Gln Asp 225 230 235 240 agc agg gtc gtg gcc cgc tct gtc cgc atc ctg gtg gct tcc ttc ttc 768 Ser Arg Val Val Ala Arg Ser Val Arg Ile Leu Val Ala Ser Phe Phe 245 250 255 ctc tgc tgg ttt ccc aac cat gtg gtc act ctc tgg ggt gtc ctg gtg 816 Leu Cys Trp Phe Pro Asn His Val Val Thr Leu Trp Gly Val Leu Val 260 265 270 aag ttt gac ctg gtg ccc tgg aac agt act ttc tat act atc cag acg 864 Lys Phe Asp Leu Val Pro Trp Asn Ser Thr Phe Tyr Thr Ile Gln Thr 275 280 285 tat gtc ttc cct gtc act act tgc ttg gca cac agc aat agc tgc ctc 912 Tyr Val Phe Pro Val Thr Thr Cys Leu Ala His Ser Asn Ser Cys Leu 290 295 300 aac cct gtg ctg tac tgt ctc ctg agg cgg gag ccc cgg cag gct ctg 960 Asn Pro Val Leu Tyr Cys Leu Leu Arg Arg Glu Pro Arg Gln Ala Leu 305 310 315 320 gca ggc acc ttc agg gat ctg cgg ttg agg ctg tgg ccc cag ggc gga 1008 Ala Gly Thr Phe Arg Asp Leu Arg Leu Arg Leu Trp Pro Gln Gly Gly 325 330 335 ggc tgg gtg caa cag gtg gcc cta aag cag gta ggc agg cgg tgg gtc 1056 Gly Trp Val Gln Gln Val Ala Leu Lys Gln Val Gly Arg Arg Trp Val 340 345 350 gca agc aac ccc cgg gag agc cgc cct tct acc ctg ctc acc aac ctg 1104 Ala Ser Asn Pro Arg Glu Ser Arg Pro Ser Thr Leu Leu Thr Asn Leu 355 360 365 gac aga ggg aca ccc ggg tga 1125 Asp Arg Gly Thr Pro Gly 370 375 <210> 36 <211> 374 <212> PRT <213> Homo sapiens <400> 36 Met Pro Thr Leu Asn Thr Ser Ala Ser Pro Pro Thr Phe Phe Trp Ala 1 5 10 15 Asn Ala Ser Gly Gly Ser Val Leu Ser Ala Asp Asp Ala Pro Met Pro 20 25 30 Val Lys Phe Leu Ala Leu Arg Leu Met Val Ala Leu Ala Tyr Gly Leu 35 40 45 Val Gly Ala Ile Gly Leu Leu Gly Asn Leu Ala Val Leu Trp Val Leu 50 55 60 Ser Asn Cys Ala Arg Arg Ala Pro Gly Pro Pro Ser Asp Thr Phe Val 65 70 75 80 Phe Asn Leu Ala Leu Ala Asp Leu Gly Leu Ala Leu Thr Leu Pro Phe 85 90 95 Trp Ala Ala Glu Ser Ala Leu Asp Phe His Trp Pro Phe Gly Gly Ala 100 105 110 Leu Cys Lys Met Val Leu Thr Ala Thr Val Leu Asn Val Tyr Ala Ser 115 120 125 Ile Phe Leu Ile Thr Ala Leu Ser Val Ala Arg Tyr Trp Val Val Ala 130 135 140 Met Ala Ala Gly Pro Gly Thr His Leu Ser Leu Phe Trp Ala Arg Ile 145 150 155 160 Ala Thr Leu Ala Val Trp Ala Ala Ala Ala Leu Val Thr Val Pro Thr 165 170 175 Ala Val Phe Gly Val Glu Gly Glu Val Cys Gly Val Arg Leu Cys Leu 180 185 190 Leu Arg Phe Pro Ser Arg Tyr Trp Leu Gly Ala Tyr Gln Leu Gln Arg 195 200 205 Val Val Leu Ala Phe Met Val Pro Leu Gly Val Ile Thr Thr Ser Tyr 210 215 220 Leu Leu Leu Leu Ala Phe Leu Gln Arg Arg Gln Arg Arg Arg Gln Asp 225 230 235 240 Ser Arg Val Val Ala Arg Ser Val Arg Ile Leu Val Ala Ser Phe Phe 245 250 255 Leu Cys Trp Phe Pro Asn His Val Val Thr Leu Trp Gly Val Leu Val 260 265 270 Lys Phe Asp Leu Val Pro Trp Asn Ser Thr Phe Tyr Thr Ile Gln Thr 275 280 285 Tyr Val Phe Pro Val Thr Thr Cys Leu Ala His Ser Asn Ser Cys Leu 290 295 300 Asn Pro Val Leu Tyr Cys Leu Leu Arg Arg Glu Pro Arg Gln Ala Leu 305 310 315 320 Ala Gly Thr Phe Arg Asp Leu Arg Leu Arg Leu Trp Pro Gln Gly Gly 325 330 335 Gly Trp Val Gln Gln Val Ala Leu Lys Gln Val Gly Arg Arg Trp Val 340 345 350 Ala Ser Asn Pro Arg Glu Ser Arg Pro Ser Thr Leu Leu Thr Asn Leu 355 360 365 Asp Arg Gly Thr Pro Gly 370 <210> 37 <211> 1008 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1008) <400> 37 atg gaa tca tct ttc tca ttt gga gtg atc ctt gct gtc ctg gcc tcc 48 Met Glu Ser Ser Phe Ser Phe Gly Val Ile Leu Ala Val Leu Ala Ser 1 5 10 15 ctc atc att gct act aac aca cta gtg gct gtg gct gtg ctg ctg ttg 96 Leu Ile Ile Ala Thr Asn Thr Leu Val Ala Val Ala Val Leu Leu Leu 20 25 30 atc cac aag aat gat ggt gtc agt ctc tgc ttc acc ttg aat ctg gct 144 Ile His Lys Asn Asp Gly Val Ser Leu Cys Phe Thr Leu Asn Leu Ala 35 40 45 gtg gct gac acc ttg att ggt gtg gcc atc tct ggc cta ctc aca gac 192 Val Ala Asp Thr Leu Ile Gly Val Ala Ile Ser Gly Leu Leu Thr Asp 50 55 60 cag ctc tcc agc cct tct cgg ccc aca cag aag acc ctg tgc agc ctg 240 Gln Leu Ser Ser Pro Ser Arg Pro Thr Gln Lys Thr Leu Cys Ser Leu 65 70 75 80 cgg atg gca ttt gtc act tcc tcc gca gct gcc tct gtc ctc acg gtc 288 Arg Met Ala Phe Val Thr Ser Ser Ala Ala Ala Ser Val Leu Thr Val 85 90 95 atg ctg atc acc ttt gac agg tac ctt gcc atc aag cag ccc ttc cgc 336 Met Leu Ile Thr Phe Asp Arg Tyr Leu Ala Ile Lys Gln Pro Phe Arg 100 105 110 tac ttg aag atc atg agt ggg ttc gtg gcc ggg gcc tgc att gcc ggg 384 Tyr Leu Lys Ile Met Ser Gly Phe Val Ala Gly Ala Cys Ile Ala Gly 115 120 125 ctg tgg tta gtg tct tac ctc att ggc ttc ctc cca ctc gga atc ccc 432 Leu Trp Leu Val Ser Tyr Leu Ile Gly Phe Leu Pro Leu Gly Ile Pro 130 135 140 atg ttc cag cag act gcc tac aaa ggg cag tgc agc ttc ttt gct gta 480 Met Phe Gln Gln Thr Ala Tyr Lys Gly Gln Cys Ser Phe Phe Ala Val 145 150 155 160 ttt cac cct cac ttc gtg ctg acc ctc tcc tgc gtt ggc ttc ttc cca 528 Phe His Pro His Phe Val Leu Thr Leu Ser Cys Val Gly Phe Phe Pro 165 170 175 gcc atg ctc ctc ttt gtc ttc ttc tac tgc gac atg ctc aag att gcc 576 Ala Met Leu Leu Phe Val Phe Phe Tyr Cys Asp Met Leu Lys Ile Ala 180 185 190 tcc atg cac agc cag cag att cga aag atg gaa cat gca gga gcc atg 624 Ser Met His Ser Gln Gln Ile Arg Lys Met Glu His Ala Gly Ala Met 195 200 205 gct gga ggt tat cga tcc cca cgg act ccc agc gac ttc aaa gct ctc 672 Ala Gly Gly Tyr Arg Ser Pro Arg Thr Pro Ser Asp Phe Lys Ala Leu 210 215 220 cgt act gtg tct gtt ctc att ggg agc ttt gct cta tcc tgg acc ccc 720 Arg Thr Val Ser Val Leu Ile Gly Ser Phe Ala Leu Ser Trp Thr Pro 225 230 235 240 ttc ctt atc act ggc att gtg cag gtg gcc tgc cag gag tgt cac ctc 768 Phe Leu Ile Thr Gly Ile Val Gln Val Ala Cys Gln Glu Cys His Leu 245 250 255 tac cta gtg ctg gaa cgg tac ctg tgg ctg ctc ggc gtg ggc aac tcc 816 Tyr Leu Val Leu Glu Arg Tyr Leu Trp Leu Leu Gly Val Gly Asn Ser 260 265 270 ctg ctc aac cca ctc atc tat gcc tat tgg cag aag gag gtg cga ctg 864 Leu Leu Asn Pro Leu Ile Tyr Ala Tyr Trp Gln Lys Glu Val Arg Leu 275 280 285 cag ctc tac cac atg gcc cta gga gtg aag aag gtg ctc acc tca ttc 912 Gln Leu Tyr His Met Ala Leu Gly Val Lys Lys Val Leu Thr Ser Phe 290 295 300 ctc ctc ttt ctc tcg gcc agg aat tgt ggc cca gag agg ccc agg gaa 960 Leu Leu Phe Leu Ser Ala Arg Asn Cys Gly Pro Glu Arg Pro Arg Glu 305 310 315 320 agt tcc tgt cac atc gtc act atc tcc agc tca gag ttt gat ggc taa 1008 Ser Ser Cys His Ile Val Thr Ile Ser Ser Ser Glu Phe Asp Gly 325 330 335 <210> 38 <211> 335 <212> PRT <213> Homo sapiens <400> 38 Met Glu Ser Ser Phe Ser Phe Gly Val Ile Leu Ala Val Leu Ala Ser 1 5 10 15 Leu Ile Ile Ala Thr Asn Thr Leu Val Ala Val Ala Val Leu Leu Leu 20 25 30 Ile His Lys Asn Asp Gly Val Ser Leu Cys Phe Thr Leu Asn Leu Ala 35 40 45 Val Ala Asp Thr Leu Ile Gly Val Ala Ile Ser Gly Leu Leu Thr Asp 50 55 60 Gln Leu Ser Ser Pro Ser Arg Pro Thr Gln Lys Thr Leu Cys Ser Leu 65 70 75 80 Arg Met Ala Phe Val Thr Ser Ser Ala Ala Ala Ser Val Leu Thr Val 85 90 95 Met Leu Ile Thr Phe Asp Arg Tyr Leu Ala Ile Lys Gln Pro Phe Arg 100 105 110 Tyr Leu Lys Ile Met Ser Gly Phe Val Ala Gly Ala Cys Ile Ala Gly 115 120 125 Leu Trp Leu Val Ser Tyr Leu Ile Gly Phe Leu Pro Leu Gly Ile Pro 130 135 140 Met Phe Gln Gln Thr Ala Tyr Lys Gly Gln Cys Ser Phe Phe Ala Val 145 150 155 160 Phe His Pro His Phe Val Leu Thr Leu Ser Cys Val Gly Phe Phe Pro 165 170 175 Ala Met Leu Leu Phe Val Phe Phe Tyr Cys Asp Met Leu Lys Ile Ala 180 185 190 Ser Met His Ser Gln Gln Ile Arg Lys Met Glu His Ala Gly Ala Met 195 200 205 Ala Gly Gly Tyr Arg Ser Pro Arg Thr Pro Ser Asp Phe Lys Ala Leu 210 215 220 Arg Thr Val Ser Val Leu Ile Gly Ser Phe Ala Leu Ser Trp Thr Pro 225 230 235 240 Phe Leu Ile Thr Gly Ile Val Gln Val Ala Cys Gln Glu Cys His Leu 245 250 255 Tyr Leu Val Leu Glu Arg Tyr Leu Trp Leu Leu Gly Val Gly Asn Ser 260 265 270 Leu Leu Asn Pro Leu Ile Tyr Ala Tyr Trp Gln Lys Glu Val Arg Leu 275 280 285 Gln Leu Tyr His Met Ala Leu Gly Val Lys Lys Val Leu Thr Ser Phe 290 295 300 Leu Leu Phe Leu Ser Ala Arg Asn Cys Gly Pro Glu Arg Pro Arg Glu 305 310 315 320 Se r Ser Cys His Ile Val Thr Ile Ser Ser Ser Glu Phe Asp Gly 325 330 335 <210> 39 <211> 822 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(822) <400> 39 atg ttg gca caa gat cca agg agt ttg gga ggt ggt ttt ttt ttt ttt 48 Met Leu Ala Gln Asp Pro Arg Ser Leu Gly Gly Gly Phe Phe Phe Phe 1 5 10 15 ttt ttt ttt ttt tcg ctc ccc ccc ctg gtg ggg ctg ttg ggg gcg gat 96 Phe Phe Phe Phe Ser Leu Pro Pro Leu Val Gly Leu Leu Gly Ala Asp 20 25 30 tct gtg ttt tgt gtt ngn gcg ctc ttt tgc gtc tgg gcc tgt gct tct 144 Ser Val Phe Cys Val Xaa Ala Leu Phe Cys Val Trp Ala Cys Ala Ser 35 40 45 ggg ggg gtt ctg ctt ggg cct gct ttg ttg ttt ttt ctc ccg cgt tcg 192 Gly Gly Val Leu Leu Gly Pro Ala Leu Leu Phe Phe Leu Pro Arg Ser 50 55 60 ggc gcc ctg ccc tgt ggt gtg ccc tgg cgc gtt gcg ctt tcg gcg gct 240 Gly Ala Leu Pro Cys Gly Val Pro Trp Arg Val Ala Leu Ser Ala Ala 65 70 75 80 tat ttg ttg ggc ggt ccg ccc cac cgt ggt ggg ttc cgg tcg ctg ttg 288 Tyr Leu Leu Gly Gly Pro Pro His Arg Gly Gly Phe Arg Ser Leu Leu 85 90 95 tgc ctc ttt ccg ggc gcc gtg gct tgg cgt gtg ggg tgg tcc gcg gct 336 Cys Leu Phe Pro Gly Ala Val Ala Trp Arg Val Gly Trp Ser Ala Ala 100 105 110 gtg tct tct ccc cgg gtg ctc ttc ggg gcg tct ccc ttc ggg cgc ctc 384 Val Ser Ser Pro Arg Val Leu Phe Gly Ala Ser Pro Phe Gly Arg Leu 115 120 125 tct ggg ggg ccg tgt gcg ggc gcg tgc ggc tcg tcg cgc tcc ctc cca 432 Ser Gly Gly Pro Cys Ala Gly Ala Cys Gly Ser Ser Arg Ser Leu Pro 130 135 140 ctg ttt gtg tgg ggc ggc ggc ttc ttg ccg cgc cgc gtt cgc cgg tgt 480 Leu Phe Val Trp Gly Gly Gly Phe Leu Pro Arg Arg Val Arg Arg Cys 145 150 155 160 gtt gtg cgc ggt ctc tcc cgc gct ttg cgt ctc tta aga tta ncg gtt 528 Val Val Arg Gly Leu Ser Arg Ala Leu Arg Leu Leu Arg Leu Xaa Val 165 170 175 gcg gct gcg cga gcg ggc gtc ggc ggc gtg cgg cgg tct gcg cgc ggg 576 Ala Ala Ala Arg Ala Gly Val Gly Gly Val Arg Arg Ser Ala Arg Gly 180 185 190 ggc ggt cgc gct ata aat aca gat aga gag aaa aac acg aaa gaa agt 624 Gly Gly Arg Ala Ile Asn Thr Asp Arg Glu Lys Asn Thr Lys Glu Ser 195 200 205 att tta aaa gag act cag act tgc atg ncc gnt tcc gct act cta gng 672 Ile Leu Lys Glu Thr Gln Thr Cys Met Xaa Xaa Ser Ala Thr Leu Xaa 210 215 220 aat ccc tgt atg tct gtc ctt aag tta ata ttc cat tct ctt cat ttt 720 Asn Pro Cys Met Ser Val Leu Lys Leu Ile Phe His Ser Leu His Phe 225 230 235 240 tat cac ata gta aat tta aaa tca ggt agg gca agt ctt cca act tct 768 Tyr His Ile Val Asn Leu Lys Ser Gly Arg Ala Ser Leu Pro Thr Ser 245 250 255 ttc ata ttt tat aaa ggt ttt ttg ttc ttc ttt tgc att tcc ata tac 816 Phe Ile Phe Tyr Lys Gly Phe Leu Phe Phe Phe Cys Ile Ser Ile Tyr 260 265 270 att tag 822 Ile <210> 40 <211> 273 <212> PRT <213> Homo sapiens <400> 40 Met Leu Ala Gln Asp Pro Arg Ser Leu Gly Gly Gly Phe Phe Phe Phe 1 5 10 15 Phe Phe Phe Phe Ser Leu Pro Pro Leu Val Gly Leu Leu Gly Ala Asp 20 25 30 Ser Val Phe Cys Val Xaa Ala Leu Phe Cys Val Trp Ala Cys Ala Ser 35 40 45 Gly Gly Val Leu Leu Gly Pro Ala Leu Leu Phe Phe Leu Pro Arg Ser 50 55 60 Gly Ala Leu Pro Cys Gly Val Pro Trp Arg Val Ala Leu Ser Ala Ala 65 70 75 80 Tyr Leu Leu Gly Gly Pro Pro His Arg Gly Gly Phe Arg Ser Leu Leu 85 90 95 Cys Leu Phe Pro Gly Ala Val Ala Trp Arg Val Gly Trp Ser Ala Ala 100 105 110 Val Ser Ser Pro Arg Val Leu Phe Gly Ala Ser Pro Phe Gly Arg Leu 115 120 125 Ser Gly Gly Pro Cys Ala Gly Ala Cys Gly Ser Ser Arg Ser Leu Pro 130 135 140 Leu Phe Val Trp Gly Gly Gly Phe Leu Pro Arg Arg Val Arg Arg Cys 145 150 155 160 Val Val Arg Gly Leu Ser Arg Ala Leu Arg Leu Leu Arg Leu Xaa Val 165 170 175 Ala Ala Ala Arg Ala Gly Val Gly Gly Val Arg Arg Ser Ala Arg Gly 180 185 190 Gly Gly Arg Ala Ile Asn Thr Asp Arg Glu Lys Asn Thr Lys Glu Ser 195 200 205 Ile Leu Lys Glu Thr Gln Thr Cys Met Xaa Xaa Ser Ala Thr Leu Xaa 210 215 220 Asn Pro Cys Met Ser Val Leu Lys Leu Ile Phe His Ser Leu His Phe 225 230 235 240 Tyr His Ile Val Asn Leu Lys Ser Gly Arg Ala Ser Leu Pro Thr Ser 245 250 255 Phe Ile Phe Tyr Lys Gly Phe Leu Phe Phe Phe Cys Ile Ser Ile Tyr 260 265 270 Ile <210> 41 <211> 966 <21 2> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(966) <400> 41 atg aac cag act ttg aat agc agt ggg acc gtg gag tca gcc cta aac 48 Met Asn Gln Thr Leu Asn Ser Ser Gly Thr Val Glu Ser Ala Leu Asn 1 5 10 15 tat tcc aga ggg agc aca gtg cac acg gcc tac ctg gtg ctg agc tcc 96 Tyr Ser Arg Gly Ser Thr Val His Thr Ala Tyr Leu Val Leu Ser Ser 20 25 30 ctg gcc atg ttc acc tgc ctg tgc ggg atg gca ggc aac agc atg gtg 144 Leu Ala Met Phe Thr Cys Leu Cys Gly Met Ala Gly Asn Ser Met Val 35 40 45 atc tgg ctg ctg ggc ttt cga atg cac agg aac ccc ttc tgc atc tat 192 Ile Trp Leu Leu Gly Phe Arg Met His Arg Asn Pro Phe Cys Ile Tyr 50 55 60 atc ctc aac ctg gcg gca gcc gac ctc ctc ttc ctc ttc agc atg gct 240 Ile Leu Asn Leu Ala Ala Ala Asp Leu Leu Phe Leu Phe Ser Met Ala 65 70 75 80 tcc acg ctc agc ctg gaa acc cag ccc ctg gtc aat acc act gac aag 288 Ser Thr Leu Ser Leu Glu Thr Gln Pro Leu Val Asn Thr Thr Asp Lys 85 90 95 gtc cac gag ctg atg aag aga ctg atg tac ttt gcc tac aca gtg ggc 336 Val His Glu Leu Met Lys Arg Leu Met Tyr Phe Ala Tyr Thr Val Gly 100 105 110 ctg agc ctg ctg acg gcc atc agc acc cag cgc tgt ctc tct gtc ctc 384 Leu Ser Leu Leu Thr Ala Ile Ser Thr Gln Arg Cys Leu Ser Val Leu 115 120 125 ttc cct atc tgg ttc aag tgt cac cgg ccc agg cac ctg tca gcc tgg 432 Phe Pro Ile Trp Phe Lys Cys His Arg Pro Arg His Leu Ser Ala Trp 130 135 140 gtg tgt ggc ctg ctg tgg aca ctc tgt ctc ctg atg aac ggg ttg acc 480 Val Cys Gly Leu Leu Trp Thr Leu Cys Leu Leu Met Asn Gly Leu Thr 145 150 155 160 tct tcc ttc tgc agc aag ttc ttg aaa ttc aat gaa gat cgg tgc ttc 528 Ser Ser Phe Cys Ser Lys Phe Leu Lys Phe Asn Glu Asp Arg Cys Phe 165 170 175 agg gtg gac atg gtc cag gcc gcc ctc atc atg ggg gtc tta acc cca 576 Arg Val Asp Met Val Gln Ala Ala Leu Ile Met Gly Val Leu Thr Pro 180 185 190 gtg atg act ctg tcc agc ctg acc ctc ttt gtc tgg gtg cgg agg agc 624 Val Met Thr Leu Ser Ser Leu Thr Leu Phe Val Trp Val Arg Arg Ser 195 200 205 tcc cag cag tgg cgg cgg cag ccc aca cgg ctg ttc gtg gtg gtc ctg 672 Ser Gln Gln Trp Arg Arg Gln Pro Thr Arg Leu Phe Val Val Val Leu 210 215 220 gcc tct gtc ctg gtg ttc ctc atc tgt tcc ctg cct ctg agc atc tac 720 Ala Ser Val Leu Val Phe Leu Ile Cys Ser Leu Pro Leu Ser Ile Tyr 225 230 235 240 tgg ttt gtg ctc tac tgg ttg agc ctg ccg ccc gag atg cag gtc ctg 768 Trp Phe Val Leu Tyr Trp Leu Ser Leu Pro Pro Glu Met Gln Val Leu 245 250 255 tgc ttc agc ttg tca cgc ctc tcc tcg tcc gta agc agc agc gcc aac 816 Cys Phe Ser Leu Ser Arg Leu Ser Ser Ser Val Ser Ser Ser Ala Asn 260 265 270 ccc gtc atc tac ttc ctg gtg ggc agc cgg agg agc cac agg ctg ccc 864 Pro Val Ile Tyr Phe Leu Val Gly Ser Arg Arg Ser His Arg Leu Pro 275 280 285 acc agg tcc ctg ggg act gtg ctc caa cag gcg ctt cgc gag gag ccc 912 Thr Arg Ser Leu Gly Thr Val Leu Gln Gln Ala Leu Arg Glu Glu Pro 290 295 300 gag ctg gaa ggt ggg gag acg ccc acc gtg ggc acc aat gag atg ggg 960 Glu Leu Glu Gly Gly Glu Thr Pro Thr Val Gly Thr Asn Glu Met Gly 305 310 315 320 gct tga 966 Ala <210> 42 <211> 321 <212> PRT <213> Homo sapiens <400> 42 Met Asn Gln Thr Leu Asn Ser Ser Gly Thr Val Glu Ser Ala Leu Asn 1 5 10 15 Tyr Ser Arg Gly Ser Thr Val His Thr Ala Tyr Leu Val Leu Ser Ser 20 25 30 Leu Ala Met Phe Thr Cys Leu Cys Gly Met Ala Gly Asn Ser Met Val 35 40 45 Ile Trp Leu Leu Gly Phe Arg Met His Arg Asn Pro Phe Cys Ile Tyr 50 55 60 Ile Leu Asn Leu Ala Ala Ala Asp Leu Leu Phe Leu Phe Ser Met Ala 65 70 75 80 Ser Thr Leu Ser Leu Glu Thr Gln Pro Leu Val Asn Thr Thr Asp Lys 85 90 95 Val His Glu Leu Met Lys Arg Leu Met Tyr Phe Ala Tyr Thr Val Gly 100 105 110 Leu Ser Leu Leu Thr Ala Ile Ser Thr Gln Arg Cys Leu Ser Val Leu 115 120 125 Phe Pro Ile Trp Phe Lys Cys His Arg Pro Arg His Leu Ser Ala Trp 130 135 140 Val Cys Gly Leu Leu Trp Thr Leu Cys Leu Leu Met Asn Gly Leu Thr 145 150 155 160 Ser Ser Phe Cys Ser Lys Phe Leu Lys Phe Asn Glu Asp Arg Cys Phe 165 170 175 Arg Val Asp Met Val Gln Ala Ala Leu Ile Met Gly Val Leu Thr Pro 180 185 190 Val Met Thr Leu Ser Ser Leu Thr Leu Phe Val Trp Val Arg Arg Ser 195 200 205 Ser Gln Gln Trp Arg Arg Gln Pro Thr Arg Leu Phe Val Val Val Leu 210 215 220 Ala Ser Val Leu Val Phe Leu Ile Cys Ser Leu Pro Leu Ser Ile Tyr 225 230 235 240 Trp Phe Val Leu Tyr Trp Leu Ser Leu Pro Pro Glu Met Gln Val Leu 245 250 255 Cys Phe Ser Leu Ser Arg Leu Ser Ser Ser Val Ser Ser Ser Ala Asn 260 265 270 Pro Val Ile Tyr Phe Leu Val Gly Ser Arg Arg Ser His Arg Leu Pro 275 280 285 Thr Arg Ser Leu Gly Thr Val Leu Gln Gln Ala Leu Arg Glu Glu Pro 290 295 300 Glu Leu Glu Gly Gly Glu Thr Pro Thr Val Gly Thr Asn Glu Met Gly 305 310 315 320 Ala <210> 43 <211> 969 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(969) <400> 43 atg gat cca acc atc tca acc ttg gac aca gaa ctg aca cca atc aac 48 Met Asp Pro Thr Ile Ser Thr Leu Asp Thr Glu Leu Thr Pro Ile Asn 1 5 10 15 gga act gag gag act ctt tgc tac aag cag acc ttg agc ctc acg gtg 96 Gly Thr Glu Glu Thr Leu Cys Tyr Lys Gln Thr Leu Ser Leu Thr Val 20 25 30 ctg acg tgc atc gtt tcc ctt gtc ggg ctg aca gga aac gca gtt gtg 144 Leu Thr Cys Ile Val Ser Leu Val Gly Leu Thr Gly Asn Ala Val Val 35 40 45 ctc tgg ctc ctg ggc tgc cgc atg cgc agg aac gcc ttc tcc atc tac 192 Leu Trp Leu Leu Gly Cys Arg Met Arg Arg Asn Ala Phe Ser Ile Tyr 50 55 60 atc ctc aac ttg gcc gca gca gac ttc ctc ttc ctc agc ggc cgc ctt 240 Ile Leu Asn Leu Ala Ala Ala Asp Phe Leu Phe Leu Ser Gly Arg Leu 65 70 75 80 ata tat tcc ctg tta agc ttc atc agt atc ccc cat acc atc tct aaa 288 Ile Tyr Ser Leu Leu Ser Phe Ile Ser Ile Pro His Thr Ile Ser Lys 85 90 95 atc ctc tat cct gtg atg atg ttt tcc tac ttt gca ggc ctg agc ttt 336 Ile Leu Tyr Pro Val Met Met Phe Ser Tyr Phe Ala Gly Leu Ser Phe 100 105 110 ctg agt gcc gtg agc acc gag cgc tgc ctg tcc gtc ctg tgg ccc atc 384 Leu Ser Ala Val Ser Thr Glu Arg Cys Leu Ser Val Leu Trp Pro Ile 115 120 125 tgg tac cgc tgc cac cgc ccc aca cac ctg tca gcg gtg gtg tgt gtc 432 Trp Tyr Arg Cys His Arg Pro Thr His Leu Ser Ala Val Val Cys Val 130 135 140 ctg ctc tgg gcc ctg tcc ctg ctg cgg agc atc ctg gag tgg atg tta 480 Leu Leu Trp Ala Leu Ser Leu Leu Arg Ser Ile Leu Glu Trp Met Leu 145 150 155 160 tgt ggc ttc ctg ttc agt ggt gct gat tct gct tgg tgt caa aca tca 528 Cys Gly Phe Leu Phe Ser Gly Ala Asp Ser Ala Trp Cys Gln Thr Ser 165 170 175 gat ttc atc aca gtc gcg tgg ctg att ttt tta tgt gtg gtt ctc tgt 576 Asp Phe Ile Thr Val Ala Trp Leu Ile Phe Leu Cys Val Val Leu Cys 180 185 190 ggg tcc agc ctg gtc ctg ctg atc agg att ctc tgt gga tcc cgg aag 624 Gly Ser Ser Leu Val Leu Leu Ile Arg Ile Leu Cys Gly Ser Arg Lys 195 200 205 ata ccg ctg acc agg ctg tac gtg acc atc ctg ctc aca gta ctg gtc 672 Ile Pro Leu Thr Arg Leu Tyr Val Thr Ile Leu Leu Thr Val Leu Val 210 215 220 ttc ctc ctc tgt ggc ctg ccc ttt ggc att cag ttt ttc cta ttt tta 720 Phe Leu Leu Cys Gly Leu Pro Phe Gly Ile Gln Phe Phe Leu Phe Leu 225 230 235 240 tgg atc cac gtg gac agg gaa gtc tta ttt tgt cat gtt cat cta gtt 768 Trp Ile His Val Asp Arg Glu Val Leu Phe Cys His Val His Leu Val 245 250 255 tct att ttc ctg tcc gct ctt aac agc agt gcc aac ccc atc att tac 816 Ser Ile Phe Leu Ser Ala Leu Asn Ser Ser Ala Asn Pro Ile Ile Tyr 260 265 270 ttc ttc gtg ggc tcc ttt agg cag cgt caa aat agg cag aac ctg aag 864 Phe Phe Val Gly Ser Phe Arg Gln Arg Gln Asn Arg Gln Asn Leu Lys 275 280 285 ctg gtt ctc cag agg gct ctg cag gac gcg tct gag gtg gat gaa ggt 912 Leu Val Leu Gln Arg Ala Leu Gln Asp Ala Ser Glu Val Asp Glu Gly 290 295 300 gga ggg cag ctt cct gag gaa atc ctg gag ctg tcg gga agc aga ttg 960 Gly Gly Gln Leu Pro Glu Glu Ile Leu Glu Leu Ser Gly Ser Arg Leu 305 310 315 320 gag cag tga 969 Glu Gln <210> 44 <211> 322 <212> PRT <213> Homo sapiens <400> 44 Met Asp Pro Thr Ile Ser Thr Leu Asp Thr Glu Leu Thr Pro Ile Asn 1 5 10 15 Gly Thr Glu Glu Thr Leu Cys Tyr Lys Gln Thr Leu Ser Leu Thr Val 20 25 30 L eu Thr Cys Ile Val Ser Leu Val Gly Leu Thr Gly Asn Ala Val Val 35 40 45 Leu Trp Leu Leu Gly Cys Arg Met Arg Arg Asn Ala Phe Ser Ile Tyr 50 55 60 Ile Leu Asn Leu Ala Ala Ala Asp Phe Leu Phe Leu Ser Gly Arg Leu 65 70 75 80 Ile Tyr Ser Leu Leu Ser Phe Ile Ser Ile Pro His Thr Ile Ser Lys 85 90 95 Ile Leu Tyr Pro Val Met Met Phe Ser Tyr Phe Ala Gly Leu Ser Phe 100 105 110 Leu Ser Ala Val Ser Thr Glu Arg Cys Leu Ser Val Leu Trp Pro Ile 115 120 125 Trp Tyr Arg Cys His Arg Pro Thr His Leu Ser Ala Val Val Cys Val 130 135 140 Leu Leu Trp Ala Leu Ser Leu Leu Arg Ser Ile Leu Glu Trp Met Leu 145 150 155 160 Cys Gly Phe Leu Phe Ser Gly Ala Asp Ser Ala Trp Cys Gln Thr Ser 165 170 175 Asp Phe Ile Thr Val Ala Trp Leu Ile Phe Leu Cys Val Val Leu Cys 180 185 190 Gly Ser Ser Leu Val Leu Leu Ile Arg Ile Leu Cys Gly Ser Arg Lys 195 200 205 Ile Pro Leu Thr Arg Leu Tyr Val Thr Ile Leu Leu Thr Val Leu Val 210 215 220 Phe Leu Leu Cys Gly Leu Pro Phe Gly Ile Gln Phe Phe Leu Phe Leu 225 230 235 240 Trp Ile His Val Asp Arg Glu Val Leu Phe Cys His Val His Leu Val 245 250 255 Ser Ile Phe Leu Ser Ala Leu Asn Ser Ser Ala Asn Pro Ile Ile Tyr 260 265 270 Phe Phe Val Gly Ser Phe Arg Gln Arg Gln Asn Arg Gln Asn Leu Lys 275 280 285 Leu Val Leu Gln Arg Ala Leu Gln Asp Ala Ser Glu Val Asp Glu Gly 290 295 300 Gly Gly Gln Leu Pro Glu Glu Ile Leu Glu Leu Ser Gly Ser Arg Leu 305 310 315 320 Glu Gln <210> 45 <211> 1191 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1191) <400> 45 atg tgg aac agc tct gac gcc aac ttc tcc tgc tac cat gag tct gtg 48 Met Trp Asn Ser Ser Asp Ala Asn Phe Ser Cys Tyr His Glu Ser Val 1 5 10 15 ctg ggc tat cgt tat gtt gca gtt agc tgg ggg gtg gtg gtg gct gtg 96 Leu Gly Tyr Arg Tyr Val Ala Val Ser Trp Gly Val Val Val Ala Val 20 25 30 aca ggc acc gtg ggc aat gtg ctc acc cta ctg gcc ttg gcc atc cag 144 Thr Gly Thr Val Gly Asn Val Leu Thr Leu Leu Ala Leu Ala Ile Gln 35 40 45 ccc aag ctc cgt acc cga ttc aac ctg ctc ata gcc aac ctc aca ctg 192 Pro Lys Leu Arg Thr Arg Phe Asn Leu Leu Ile Ala Asn Leu Thr Leu 50 55 60 gct gat ctc ctc tac tgc acg ctc ctt cag ccc ttc tct gtg gac acc 240 Ala Asp Leu Leu Tyr Cys Thr Leu Leu Gln Pro Phe Ser Val Asp Thr 65 70 75 80 tac ctc cac ctg cac tgg cgc acc ggt gcc acc ttc tgc agg gta ttt 288 Tyr Leu His Leu His Trp Arg Thr Gly Ala Thr Phe Cys Arg Val Phe 85 90 95 ggg ctc ctc ctt ttt gcc tcc aat tct gtc tcc atc ctg acc ctc tgc 336 Gly Leu Leu Leu Phe Ala Ser Asn Ser Val Ser Ile Leu Thr Leu Cys 100 105 110 ctc atc gca ctg gga cgc tac ctc ctc att gcc cac cct aag ctt ttt 384 Leu Ile Ala Leu Gly Arg Tyr Leu Leu Ile Ala His Pro Lys Leu Phe 115 120 125 ccc caa gtt ttc agt gcc aag ggg ata gtg ctg gca ctg gtg agc acc 432 Pro Gln Val Phe Ser Ala Lys Gly Ile Val Leu Ala Leu Val Ser Thr 130 135 140 tgg gtt gtg ggc gtg gcc agc ttt gct ccc ctc tgg cct att tat atc 480 Trp Val Val Gly Val Ala Ser Phe Ala Pro Leu Trp Pro Ile Tyr Ile 145 150 155 160 ctg gta cct gta gtc tgc acc tgc agc ttt gac cgc atc cga ggc cgg 528 Leu Val Pro Val Val Cys Thr Cys Ser Phe Asp Arg Ile Arg Gly Arg 165 170 175 cct tac acc acc atc ctc atg ggc atc tac ttt gtg ctt ggg ctc agc 576 Pro Tyr Thr Thr Ile Leu Met Gly Ile Tyr Phe Val Leu Gly Leu Ser 180 185 190 agt gtt ggc atc ttc tat tgc ctc atc cac cgc cag gtc aaa cga gca 624 Ser Val Gly Ile Phe Tyr Cys Leu Ile His Arg Gln Val Lys Arg Ala 195 200 205 gca cag gca ctg gac caa tac aag ttg cga cag gca agc atc cac tcc 672 Ala Gln Ala Leu Asp Gln Tyr Lys Leu Arg Gln Ala Ser Ile His Ser 210 215 220 aac cat gtg gcc agg act gat gag gcc atg cct ggt cgt ttc cag gag 720 Asn His Val Ala Arg Thr Asp Glu Ala Met Pro Gly Arg Phe Gln Glu 225 230 235 240 ctg gac agc agg tta gca tca gga gga ccc agt gag ggg att tca tct 768 Leu Asp Ser Arg Leu Ala Ser Gly Gly Pro Ser Glu Gly Ile Ser Ser 245 250 255 gag cca gtc agt gct gcc acc acc cag acc ctg gaa ggg gac tca tca 816 Glu Pro Val Ser Ala Ala Thr Thr Gln Thr Leu Glu Gly Asp Ser Ser 260 265 270 gaa gtg gga gac cag atc aac agc aag aga gct aag cag atg gca gag 864 Glu Val Gly Asp Gln Ile Asn Ser Lys Arg Ala Lys Gln Met Ala Glu 275 280 285 aaa agc cct cca gaa gca tct gcc aaa gcc cag cca att aaa gga gcc 912 Lys Ser Pro Pro Glu Ala Ser Ala Lys Ala Gln Pro Ile Lys Gly Ala 290 295 300 aga aga gct ccg gat tct tca tcg gaa ttt ggg aag gtg act cga atg 960 Arg Arg Ala Pro Asp Ser Ser Ser Glu Phe Gly Lys Val Thr Arg Met 305 310 315 320 tgt ttt gct gtg ttc ctc tgc ttt gcc ctg agc tac atc ccc ttc ttg 1008 Cys Phe Ala Val Phe Leu Cys Phe Ala Leu Ser Tyr Ile Pro Phe Leu 325 330 335 ctg ctc aac att ctg gat gcc aga gtc cag gct ccc cgg gtg gtc cac 1056 Leu Leu Asn Ile Leu Asp Ala Arg Val Gln Ala Pro Arg Val Val His 340 345 350 atg ctt gct gcc aac ctc acc tgg ctc aat ggt tgc atc aac cct gtg 1104 Met Leu Ala Ala Asn Leu Thr Trp Leu Asn Gly Cys Ile Asn Pro Val 355 360 365 ctc tat gca gcc atg aac cgc caa ttc cgc caa gca tat ggc tcc att 1152 Leu Tyr Ala Ala Met Asn Arg Gln Phe Arg Gln Ala Tyr Gly Ser Ile 370 375 380 tta aaa aga ggg ccc cgg agt ttc cat agg ctc cat tag 1191 Leu Lys Arg Gly Pro Arg Ser Phe His Arg Leu His 385 390 395 <210> 46 <211> 396 <212> PRT <213> Homo sapiens <400> 46 Met Trp Asn Ser Ser Asp Ala Asn Phe Ser Cys Tyr His Glu Ser Val 1 5 10 15 Leu Gly Tyr Arg Tyr Val Ala Val Ser Trp Gly Val Val Val Ala Val 20 25 30 Thr Gly Thr Val Gly Asn Val Leu Thr Leu Leu Ala Leu Ala Ile Gln 35 40 45 Pro Lys Leu Arg Thr Arg Phe Asn Leu Leu Ile Ala Asn Leu Thr Leu 50 55 60 Ala Asp Leu Leu Tyr Cys Thr Leu Leu Gln Pro Phe Ser Val Asp Thr 65 70 75 80 Tyr Leu His Leu His Trp Arg Thr Gly Ala Thr Phe Cys Arg Val Phe 85 90 95 Gly Leu Leu Leu Phe Ala Ser Asn Ser Val Ser Ile Leu Thr Leu Cys 100 105 110 Leu Ile Ala Leu Gly Arg Tyr Leu Leu Ile Ala His Pro Lys Leu Phe 115 120 125 Pro Gln Val Phe Ser Ala Lys Gly Ile Val Leu Ala Leu Val Ser Thr 130 135 140 Trp Val Val Gly Val Ala Ser Phe Ala Pro Leu Trp Pro Ile Tyr Ile 145 150 155 160 Leu Val Pro Val Val Cys Thr Cys Ser Phe Asp Arg Ile Arg Gly Arg 165 170 175 Pro Tyr Thr Thr Ile Leu Met Gly Ile Tyr Phe Val Leu Gly Leu Ser 180 185 190 Ser Val Gly Ile Phe Tyr Cys Leu Ile His Arg Gln Val Lys Arg Ala 195 200 205 Ala Gln Ala Leu Asp Gln Tyr Lys Leu Arg Gln Ala Ser Ile His Ser 210 215 220 Asn His Val Ala Arg Thr Asp Glu Ala Met Pro Gly Arg Phe Gln Glu 225 230 235 240 Leu Asp Ser Arg Leu Ala Ser Gly Gly Pro Ser Glu Gly Ile Ser Ser 245 250 255 Glu Pro Val Ser Ala Ala Thr Thr Gln Thr Leu Glu Gly Asp Ser Ser 260 265 270 Glu Val Gly Asp Gln Ile Asn Ser Lys Arg Ala Lys Gln Met Ala Glu 275 280 285 Lys Ser Pro Pro Glu Ala Ser Ala Lys Ala Gln Pro Ile Lys Gly Ala 290 295 300 Arg Arg Ala Pro Asp Ser Ser Ser Glu Phe Gly Lys Val Thr Arg Met 305 310 315 320 Cys Phe Ala Val Phe Leu Cys Phe Ala Leu Ser Tyr Ile Pro Phe Leu 325 330 335 Leu Leu Asn Ile Leu Asp Ala Arg Val Gln Ala Pro Arg Val Val His 340 345 350 Met Leu Ala Ala Asn Leu Thr Trp Leu Asn Gly Cys Ile Asn Pro Val 355 360 365 Leu Tyr Ala Ala Met Asn Arg Gln Phe Arg Gln Ala Tyr Gly Ser Ile 370 375 380 Leu Lys Arg Gly Pro Arg Ser Phe His Arg Leu His 385 390 395 <210> 47 <211> 921 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(921) <400> 47 atg tat ttt aaa agt gat gag cta gag ttt gca aaa agt ttt att gga 48 Met Tyr Phe Lys Ser Asp Glu Leu Glu Phe Ala Lys Ser Phe Ile Gly 1 5 10 15 aca gtt tca ata ttt tgt ctt tgt gca act ctg ttc aca ttc ctt act 96 Thr Val Ser Ile Phe Cys Leu Cys Ala Thr Leu Phe Thr Phe Leu Thr 20 25 30 ttt tta att gat gtt aga aga ttc aga tac cca gag aga cca att ata 144 Phe Leu Ile Asp Val Arg Arg Phe Arg Tyr Pro Glu Arg Pro Ile Ile 35 40 45 tat tac tct gtc tgt tac agc att gta tct ctt atg tac ttc att gga 192 Tyr Tyr Ser Val Cys Tyr Ser Ile Val Ser Leu Met Tyr Phe Ile Gly 50 55 60 ttt ttg cta ggc gat agc aca gcc tgc aat aag gca gat gag aag cta 240 Phe Leu Leu Gly Asp Ser Thr Ala Cys Asn Lys Ala Asp Glu Lys Leu 65 70 75 80 gaa ctt ggt gac act gtt gtc cta ggc tct caa aat aag gct tgc acc 288 Glu Leu Gly Asp Thr Val Val Leu Gly Ser Gln Asn Lys Ala Cys Thr 85 90 95 gtt ttg ttc atg ctt ttg tat ttt ttc aca atg gct ggc act gtg tgg 336 Val Leu Phe Met Leu Leu Tyr Phe Phe Thr Met Ala Gly Thr Val Trp 100 105 110 tgg gtg att ctt acc att act tgg ttc tta gct gca gga aga aaa tgg 384 Trp Val Ile Leu Thr Ile Thr Trp Phe Leu Ala Ala Gly Arg Lys Trp 115 120 125 agt tgt gaa gcc atc gag caa aaa gca gtg tgg ttt cat gct gtt gca 432 Ser Cys Glu Ala Ile Glu Gln Lys Ala Val Trp Phe His Ala Val Ala 130 135 140 tgg gga aca cca ggt ttc ctg act gtt atg ctt ctt gct atg aac aaa 480 Trp Gly Thr Pro Gly Phe Leu Thr Val Met Leu Leu Ala Met Asn Lys 145 150 155 160 gtt gaa gga gac aac att agt gga gtt tgc ttt gtt ggc ctt tat gac 528 Val Glu Gly Asp Asn Ile Ser Gly Val Cys Phe Val Gly Leu Tyr Asp 165 170 175 ctg gat gct tct cgc tac ttt gta ctc ttg cca ctg tgc ctt tgt gtg 576 Leu Asp Ala Ser Arg Tyr Phe Val Leu Leu Pro Leu Cys Leu Cys Val 180 185 190 ttt gtt ggg ctc tct ctt ctt tta gct ggc att att tcc tta aat cat 624 Phe Val Gly Leu Ser Leu Leu Leu Ala Gly Ile Ile Ser Leu Asn His 195 200 205 gtt cga caa gtc ata caa cat gat ggc cgg aac caa gaa aaa cta aag 672 Val Arg Gln Val Ile Gln His Asp Gly Arg Asn Gln Glu Lys Leu Lys 210 215 220 aaa ttt atg att cga att gga gtc ttc agc ggc ttg tat ctt gtg cca 720 Lys Phe Met Ile Arg Ile Gly Val Phe Ser Gly Leu Tyr Leu Val Pro 225 230 235 240 tta gtg aca ctt ctc gga tgt tac gtc tat gag caa gtg aac agg att 768 Leu Val Thr Leu Leu Gly Cys Tyr Val Tyr Glu Gln Val Asn Arg Ile 245 250 255 acc tgg gag ata act tgg gtc tct gat cat tgt cgt cag tac cat atc 816 Thr Trp Glu Ile Thr Trp Val Ser Asp His Cys Arg Gln Tyr His Ile 260 265 270 cca tgt cct tat cag gta aaa gct atc act tgg att atg tct cta ttt 864 Pro Cys Pro Tyr Gln Val Lys Ala Ile Thr Trp Ile Met Ser Leu Phe 275 280 285 aca ttt aat gta gaa aat gtt tca tgg aaa tat act tgt cat gga tgt 912 Thr Phe Asn Val Glu Asn Val Ser Trp Lys Tyr Thr Cys His Gly Cys 290 295 300 aaa agt tga 921 Lys Ser 305 <210> 48 <211> 306 <212> PRT <213> Homo sapiens <400> 48 Met Tyr Phe Lys Ser Asp Glu Leu Glu Phe Ala Lys Ser Phe Ile Gly 1 5 10 15 Thr Val Ser Ile Phe Cys Leu Cys Ala Thr Leu Phe Thr Phe Leu Thr 20 25 30 Phe Leu Ile Asp Val Arg Arg Phe Arg Tyr Pro Glu Arg Pro Ile Ile 35 40 45 Tyr Tyr Ser Val Cys Tyr Ser Ile Val Ser Leu Met Tyr Phe Ile Gly 50 55 60 Phe Leu Leu Gly Asp Ser Thr Ala Cys Asn Lys Ala Asp Glu Lys Leu 65 70 75 80 Glu Leu Gly Asp Thr Val Val Leu Gly Ser Gln Asn Lys Ala Cys Thr 85 90 95 Val Leu Phe Met Leu Leu Tyr Phe Phe Thr Met Ala Gly Thr Val Trp 100 105 110 Trp Val Ile Leu Thr Ile Thr Trp Phe Leu Ala Ala Gly Arg Lys Trp 115 120 125 Ser Cys Glu Ala Ile Glu Gln Lys Ala Val Trp Phe His Ala Val Ala 130 135 140 Trp Gly Thr Pro Gly Phe Leu Thr Val Met Leu Leu Ala Met Asn Lys 145 150 155 160 Val Glu Gly Asp Asn Ile Ser Gly Val Cys Phe Val Gly Leu Tyr Asp 165 170 175 Leu Asp Ala Ser Arg Tyr Phe Val Leu Leu Pro Leu Cys Leu Cys Val 180 185 190 Phe Val Gly Leu Ser Leu Leu Leu Ala Gly Ile Ile Ser Leu Asn His 195 200 205 Val Arg Gln Val Ile Gln His Asp Gly Arg Asn Gln Glu Lys Leu Lys 210 215 220 Lys Phe Met Ile Arg Ile Gly Val Phe Ser Gly Leu Tyr Leu Val Pro 225 230 235 240 Leu Val Thr Leu Leu Gly Cys Tyr Val Tyr Glu Gln Val Asn Arg Ile 245 250 255 Thr Trp Glu Ile Thr Trp Val Ser Asp His Cys Arg Gln Tyr His Ile 260 265 270 Pro Cys Pro Tyr Gln Val Lys Ala Ile Thr Trp Ile Met Ser Leu Phe 275 280 285 T hr Phe Asn Val Glu Asn Val Ser Trp Lys Tyr Thr Cys His Gly Cys 290 295 300 Lys Ser 305 <210> 49 <211> 1257 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1257) <400> 49 atg acc ctg aca tgg cct cct ccc ttc cct gca ggt tgg agc ctc ccc 48 Met Thr Leu Thr Trp Pro Pro Pro Phe Pro Ala Gly Trp Ser Leu Pro 1 5 10 15 tct tac gtc tct gtg ctt gtg gct ctg ggg aac ctg ggt ctg ctg gtg 96 Ser Tyr Val Ser Val Leu Val Ala Leu Gly Asn Leu Gly Leu Leu Val 20 25 30 gtg acc ctc tgg agg agg ctg gcc cca gga aag gac gag cag gtc ccc 144 Val Thr Leu Trp Arg Arg Leu Ala Pro Gly Lys Asp Glu Gln Val Pro 35 40 45 atc cgg gtg gtg cag gtg ctg ggc atg gtg ggc aca gcc ctg ctg gcc 192 Ile Arg Val Val Gln Val Leu Gly Met Val Gly Thr Ala Leu Leu Ala 50 55 60 tct ctg tgg cac cat gtg gcc cca gtg gca gga cag ttg cat tct gtg 240 Ser Leu Trp His His Val Ala Pro Val Ala Gly Gln Leu His Ser Val 65 70 75 80 gcc ttc tta gca ctg gcc ttt gtg ctg gca ctg gca tgc tgt gcc tcg 288 Ala Phe Leu Ala Leu Ala Phe Val Leu Ala Leu Ala Cys Cys Ala Ser 85 90 95 aat gtc act ttc ctg ccc ttc ttg agc cac ctg cca cct cgc ttc tta 336 Asn Val Thr Phe Leu Pro Phe Leu Ser His Leu Pro Pro Arg Phe Leu 100 105 110 cgg tca ttc ttc ctg ggt caa ggc ctg agt gcc ctg ctg ccc tgc gtg 384 Arg Ser Phe Phe Leu Gly Gln Gly Leu Ser Ala Leu Leu Pro Cys Val 115 120 125 ctg gcc cta gtg cag ggt gtg ggc cgc ctc gag tgc ccg cca gcc ccc 432 Leu Ala Leu Val Gln Gly Val Gly Arg Leu Glu Cys Pro Pro Ala Pro 130 135 140 atc aac ggc acc cct ggc ccc ccg ctc gac ttc ctt gag cgt ttt ccc 480 Ile Asn Gly Thr Pro Gly Pro Pro Leu Asp Phe Leu Glu Arg Phe Pro 145 150 155 160 gcc agc acc ttc ttc tgg gca ctg act gcc ctt ctg gtc gct tca gct 528 Ala Ser Thr Phe Phe Trp Ala Leu Thr Ala Leu Leu Val Ala Ser Ala 165 170 175 gct gcc ttc cag ggt ctt ctg ctg ctg ttg ccg cca cca cca tct gta 576 Ala Ala Phe Gln Gly Leu Leu Leu Leu Leu Pro Pro Pro Pro Ser Val 180 185 190 ccc aca ggg gag tta gga tca ggc ctc cag gtg gga gcc cca gga gca 624 Pro Thr Gly Glu Leu Gly Ser Gly Leu Gln Val Gly Ala Pro Gly Ala 195 200 205 gag gaa gag gtg gaa gag tcc tca cca ctg caa gag cca cca agc cag 672 Glu Glu Glu Val Glu Glu Ser Ser Pro Leu Gln Glu Pro Pro Ser Gln 210 215 220 gca gca ggc acc acc cct ggt cca gac cct aag gcc tat cag ctt cta 720 Ala Ala Gly Thr Thr Pro Gly Pro Asp Pro Lys Ala Tyr Gln Leu Leu 22 5 230 235 240 tca gcc cgc agt gcc tgc ctg ctg ggc ctg ttg gcc gcc acc aac gcg 768 Ser Ala Arg Ser Ala Cys Leu Leu Gly Leu Leu Ala Ala Thr Asn Ala 245 250 255 ctg acc aat ggc gtg ctg cct gcc gtg cag agc ttt tcc tgc tta ccc 816 Leu Thr Asn Gly Val Leu Pro Ala Val Gln Ser Phe Ser Cys Leu Pro 260 265 270 tac ggg cgt ctg gcc tac cac ctg gct gtg gtg ctg ggc agt gct gcc 864 Tyr Gly Arg Leu Ala Tyr His Leu Ala Val Val Leu Gly Ser Ala Ala 275 280 285 aat ccc ctg gcc tgc ttc ctg gcc atg ggt gtg ctg tgc agg tac aca 912 Asn Pro Leu Ala Cys Phe Leu Ala Met Gly Val Leu Cys Arg Tyr Thr 290 295 300 agg acc ccc agc ccc tgt gcg ggt gga act cag ggc tgg gag cca ggt 960 Arg Thr Pro Ser Pro Cys Ala Gly Gly Thr Gln Gly Trp Glu Pro Gly 305 310 315 320 cct ggc gca gtc agc cct gac att ctg ctc gct cac tgc agg tcc ttg 1008 Pro Gly Ala Val Ser Pro Asp Ile Leu Leu Ala His Cys Arg Ser Leu 325 330 335 gca ggg ctg ggc ggc ctc tct ctg ctg ggc gtg ttc tgt ggg ggc tac 1056 Ala Gly Leu Gly Gly Leu Ser Leu Leu Gly Val Phe Cys Gly Gly Tyr 340 345 350 ctg atg gcg ctg gca gtc ctg agc ccc tgc ccg ccc ctg gtg ggc acc 1104 Leu Met Ala Leu Ala Val Leu Ser Pro Cys Pro Pro Leu Val Gly Thr 355 360 365 tcg gcg ggg gtg gtc ctc gtg gtg agc aca ggg gga cat gaa gtg ggg 1152 Ser Ala Gly Val Val Leu Val Val Ser Thr Gly Gly His Glu Val Gly 370 375 380 tgg ggg ggc gtt gcc ctg gag cag gca cat ctc acg ctc agc tgg tgc 1200 Trp Gly Gly Val Ala Leu Glu Gln Ala His Leu Thr Leu Ser Trp Cys 385 390 395 400 tgt gtc ccc ctc agg tgc tgt cgt ggg tgc tgt gtc ttg gcg tgt tct 1248 Cys Val Pro Leu Arg Cys Cys Arg Gly Cys Cys Val Leu Ala Cys Ser 405 410 415 cct acg tga 1257 Pro Thr <210> 50 <211> 418 <212> PRT <213> Homo sapiens <400> 50 Met Thr Leu Thr Trp Pro Pro Pro Phe Pro Ala Gly Trp Ser Leu Pro 1 5 10 15 Ser Tyr Val Ser Val Leu Val Ala Leu Gly Asn Leu Gly Leu Leu Val 20 25 30 Val Thr Leu Trp Arg Arg Leu Ala Pro Gly Lys Asp Glu Gln Val Pro 35 40 45 Ile Arg Val Val Gln Val Leu Gly Met Val Gly Thr Ala Leu Leu Ala 50 55 60 Ser Leu Trp His His Val Ala Pro Val Ala Gly Gln Leu His Ser Val 65 70 75 80 Ala Phe Leu Ala Leu Ala Phe Val Leu Ala Leu Ala Cys Cys Ala Ser 85 90 95 Asn Val Thr Phe Leu Pro Phe Leu Ser His Leu Pro Pro Arg Phe Leu 100 105 110 Arg Ser Phe Phe Leu Gly Gln Gly Leu Ser Ala Leu Leu Pro Cys Val 115 120 125 Leu Ala Leu Val Gln Gly Val Gly Arg Leu Glu Cys Pro Pro Ala Pro 130 135 140 Ile Asn Gly Thr Pro Gly Pro Pro Leu Asp Phe Leu Glu Arg Phe Pro 145 150 155 160 Ala Ser Thr Phe Phe Trp Ala Leu Thr Ala Leu Leu Val Ala Ser Ala 165 170 175 Ala Ala Phe Gln Gly Leu Leu Leu Leu Leu Pro Pro Pro Pro Ser Val 180 185 190 Pro Thr Gly Glu Leu Gly Ser Gly Leu Gln Val Gly Ala Pro Gly Ala 195 200 205 Glu Glu Glu Val Glu Glu Ser Ser Pro Leu Gln Glu Pro Pro Ser Gln 210 215 220 Ala Ala Gly Thr Thr Pro Gly Pro Asp Pro Lys Ala Tyr Gln Leu Leu 225 230 235 240 Ser Ala Arg Ser Ala Cys Leu Leu Gly Leu Leu Ala Ala Thr Asn Ala 245 250 255 Leu Thr Asn Gly Val Leu Pro Ala Val Gln Ser Phe Ser Cys Leu Pro 260 265 270 Tyr Gly Arg Leu Ala Tyr His Leu Ala Val Val Leu Gly Ser Ala Ala 275 280 285 Asn Pro Leu Ala Cys Phe Leu Ala Met Gly Val Leu Cys Arg Tyr Thr 290 295 300 Arg Thr Pro Ser Pro Cys Ala Gly Gly Thr Gln Gly Trp Glu Pro Gly 305 310 315 320 Pro Gly Ala Val Ser Pro Asp Ile Leu Leu Ala His Cys Arg Ser Leu 325 330 335 Ala Gly Leu Gly Gly Leu Ser Leu Leu Gly Val Phe Cys Gly Gly Tyr 340 345 350 Leu Met Ala Leu Ala Val Leu Ser Pro Cys Pro Pro Leu Val Gly Thr 355 360 365 Ser Ala Gly Val Val Leu Val Val Ser Thr Gly Gly His Glu Val Gly 370 375 380 Trp Gly Gly Val Ala Leu Glu Gln Ala His Leu Thr Leu Ser Trp Cys 385 390 395 400 Cys Val Pro Leu Arg Cys Cys Arg Gly Cys Cys Val Leu Ala Cys Ser 405 410 415 Pro Thr <210> 51 <211> 1098 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1098) <400> 51 atg agg gct ctg gga tat tca cag tgg aag ggg aca att gga ttt ctt 48 Met Arg Ala Leu Gly Tyr Ser Gln Trp Lys Gly Thr Ile Gly Phe Leu 1 5 10 15 tac agt caa ttc tct gtt ctt cgt tca ata ggt gaa agg gag tgt gaa 96 Tyr Ser Gln Phe Ser Val Leu Arg Ser Ile Gly Glu Arg Glu Cys Glu 20 25 30 caa tgt ggt gaa gac tat tgg tca aat gca caa aag agc gag tgt gtg 144 Gln Cys Gly Glu Asp Tyr Trp Ser Asn Ala Gln Lys Ser Glu Cys Val 35 40 45 ctg aaa gag gtg gaa tac ctt gct tat gat gag gcc ctg gga ttc aca 192 Leu Lys Glu Val Glu Tyr Leu Ala Tyr Asp Glu Ala Leu Gly Phe Thr 50 55 60 ctt gtc att ctt tct gtc ttt ggg gca ttt gtg gtc ttg gca gtc aca 240 Leu Val Ile Leu Ser Val Phe Gly Ala Phe Val Val Leu Ala Val Thr 65 70 75 80 gct gtg tat gtg ata cac agg cac act ccc ctg gtg aac gcc agt gac 288 Ala Val Tyr Val Ile His Arg His Thr Pro Leu Val Asn Ala Ser Asp 85 90 95 tgg cag ctg ggc ttt ctc att cag gtt tct ctg atc atc atg ctg ctg 336 Trp Gln Leu Gly Phe Leu Ile Gln Val Ser Leu Ile Ile Met Leu Leu 100 105 110 tcg tcc atg ctt ttc att gac aag cca cac aac tgg tcc tgc atg gct 384 Ser Ser Met Leu Phe Ile Asp Lys Pro His Asn Trp Ser Cys Met Ala 115 120 125 ggc cag gtc act ctg gca ctg ggc ttt tct ctt tgc ctg tct tgc ctt 432 Gly Gln Val Thr Leu Ala Leu Gly Phe Ser Leu Cys Leu Ser Cys Leu 130 135 140 ctt gga aag act agt tca ctg ttt tta gcc tac aga att tcc aaa tcc 480 Leu Gly Lys Thr Ser Ser Leu Phe Leu Ala Tyr Arg Ile Ser Lys Ser 145 150 155 160 aaa act caa ctt aca tcc atg cac ccc ctt tat cgg aaa atc att gtg 528 Lys Thr Gln Leu Thr Ser Met His Pro Leu Tyr Arg Lys Ile Ile Val 165 170 175 cta atc tct gtt cta gcg gag att ggc ata tgt aca gcc tac ttg ata 576 Leu Ile Ser Val Leu Ala Glu Ile Gly Ile Cys Thr Ala Tyr Leu Ile 180 185 190 ttg gaa cct ccc atg gta tac aag aac atg gaa tct caa aat aca aag 624 Leu Glu Pro Pro Met Val Tyr Lys Asn Met Glu Ser Gln Asn Thr Lys 195 200 205 atc att ctg gga tgc aat gaa att tcc ata gag ttt ttg tac tcg atg 672 Ile Ile Leu Gly Cys Asn Glu Ile Ser Ile Glu Phe Leu Tyr Ser Met 210 215 220 ttt gga att gat gcc ttc tta gcc ttg cta tgc ttt ctt aca act ttt 720 Phe Gly Ile Asp Ala Phe Leu Ala Leu Leu Cys Phe Leu Thr Thr Phe 225 230 235 240 gtg gct cgc cag tta cca gat aat tac tat gaa gga aaa tgc atc acc 768 Val Ala Arg Gln Leu Pro Asp Asn Tyr Tyr Glu Gly Lys Cys Ile Thr 245 250 255 ttt ggg atg ctt gtc ttt ttc atc att tgg atg tct ttt gtc cct gtt 816 Phe Gly Met Leu Val Phe Phe Ile Ile Trp Met Ser Phe Val Pro Val 260 265 270 tat ttg agc acc aaa ggc aag ttc aaa atg gct gtg gaa ata ttt gca 864 Tyr Leu Ser Thr Lys Gly Lys Phe Lys Met Ala Val Glu Ile Phe Ala 275 280 285 atc ttg gca tcc agc cat ggc ttg ttg ggt tgt ata ttt gct cct aag 912 Ile Leu Ala Ser Ser His Gly Leu Leu Gly Cys Ile Phe Ala Pro Lys 290 295 300 tgc ctc att att ttg ctg agg cca gag agg aac acc agt gaa att gtt 960 Cys Leu Ile Ile Leu Leu Arg Pro Glu Arg Asn Thr Ser Glu Ile Val 305 310 315 320 tgt gga aga gtc tcc acc aca gat aat tgc atc caa ctg acc tca gct 1008 Cys Gly Arg Val Ser Thr Thr Asp Asn Cys Ile Gln Leu Thr Ser Ala 325 330 335 ttt gtg agc agt gag ctt aac aat acc aca gtg tca act gtt ctg gat 1056 Phe Val Ser Ser Glu Leu Asn Asn Thr Thr Val Ser Thr Val Leu Asp 340 345 350 gac aga gtt ttg att tac atg tgt cct ttg aag ctg caa tga 1098 Asp Arg Val Leu Ile Tyr Met Cys Pro Leu Lys Leu Gln 355 360 365 <210> 52 <211> 365 <212> PRT <213> Homo sapiens <400> 52 Met Arg Ala Leu Gly Tyr Ser Gln Trp Lys Gly Thr Ile Gly Phe Leu 1 5 10 15 Tyr Ser Gln Phe Ser Val Leu Arg Ser Ile Gly Glu Arg Glu Cys Glu 20 25 30 Gln Cys Gly Glu Asp Tyr Trp Ser Asn Ala Gln Lys Ser Glu Cys Val 35 40 45 Leu Lys Glu Val Glu Tyr Leu Ala Tyr Asp Glu Ala Leu Gly Phe Thr 50 55 60 Leu Val Ile Leu Ser Val Phe Gly Ala Phe Val Val Leu Ala Val Thr 65 70 75 80 Ala Val Tyr Val Ile His Arg His Thr Pro Leu Val Asn Ala Ser Asp 85 90 95 Trp Gln Leu Gly Phe Leu Ile Gln Val Ser Leu Ile Ile Met Leu Leu 100 105 110 Ser Ser Met Leu Phe Ile Asp Lys Pro His Asn Trp Ser Cys Met Ala 115 120 125 Gly Gln Val Thr Leu Ala Leu Gly Phe Ser Leu Cys Leu Ser Cys Leu 130 135 140 Leu Gly Lys Thr Ser Ser Leu Phe Leu Ala Tyr Arg Ile Ser Lys Ser 145 150 155 160 Lys Thr Gln Leu Thr Ser Met His Pro Leu Tyr Arg Lys Ile Ile Val 165 170 175 Leu Ile Ser Val Leu Ala Glu Ile Gly Ile Cys Thr Ala Tyr Leu Ile 180 185 190 Leu Glu Pro Pro Met Val Tyr Lys Asn Met Glu Ser Gln Asn Thr Lys 195 200 205 Ile Ile Leu Gly Cys Asn Glu Ile Ser Ile Glu Phe Leu Tyr Ser Met 210 215 220 Phe Gly Ile Asp Ala Phe Leu Ala Leu Leu Cys Phe Leu Thr Thr Phe 225 230 235 240 Val Ala Arg Gln Leu Pro Asp Asn Tyr Tyr Glu Gly Lys Cys Ile Thr 245 250 255 Phe Gly Met Leu Val Phe Phe Ile Ile Trp Met Ser Phe Val Pro Val 260 265 270 Tyr Leu Ser Thr Lys Gly Lys Phe Lys Met Ala Val Glu Ile Phe Ala 275 280 285 Ile Leu Ala Ser Ser His Gly Leu Leu Gly Cys Ile Phe Ala Pro Lys 290 295 300 Cys Leu Ile Ile Leu Leu Arg Pro Glu Arg Asn Thr Ser Glu Ile Val 305 310 315 320 Cys Gly Arg Val Ser Thr Thr Asp Asn Cys Ile Gln Leu Thr Ser Ala 325 330 335 Phe Val Ser Ser Glu Leu Asn Asn Thr Thr Val Ser Thr Val Leu Asp 340 345 350 Asp Arg Val Leu Ile Tyr Met Cys Pro Leu Lys Leu Gln 355 360 365 <210> 53 <211> 885 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(885) <400> 53 atg anc ctg gtc ggc tct agn aga tcc cca gta att agc cag ttc agt 48 Met Xaa Leu Val Gly Ser Xaa Arg Ser Pro Val Ile Ser Gln Phe Ser 1 5 10 15 ctt tct gtt act cgt aaa ctc tct ccc tgt tgg ctg cac tgc atc agt 96 Leu Ser Val Thr Arg Lys Leu Ser Pro Cys Trp Leu His Cys Ile Ser 20 25 30 aag cag agg gct gtg tgg cat gtc aaa gct aat gag gag ggc tgc ctg 144 Lys Gln Arg Ala Val Trp His Val Lys Ala Asn Glu Glu Gly Cys Leu 35 40 45 ctg ggt aag aat gtt gtt ggt ggc aga gcc gtt ttg tgc tct gct gtt 192 Leu Gly Lys Asn Val Val Gly Gly Arg Ala Val Leu Cys Ser Ala Val 50 55 60 gag aat gcc ggg tac att cac aag acg ttt cct gcg tgt ggt ggg aac 240 Glu Asn Ala Gly Tyr Ile His Lys Thr Phe Pro Ala Cys Gly Gly Asn 65 70 75 80 tgc tct can gca cca att tca tat tgt gtc cta tca gtg ggt ttc tgt 288 Cys Ser Thr Ala Pro Ile Ser Tyr Cys Val Leu Ser Val Gly Phe Cys 85 90 95 ctc ttc gtt ctg tcn nnc tcg cgg tct tcc cgt tgg tna agt cct att 336 Leu Phe Val Leu Xaa Xaa Ser Arg Ser Ser Arg Trp Xaa Ser Pro Ile 100 105 110 tac ttt tgt gtc ggt gtg ttc gcg ttg gtg tcn gtt ccg ttt ctc gtg 384 Tyr Phe Cys Val Gly Val Phe Ala Leu Val Xaa Val Pro Phe Leu Val 115 120 125 gtg tgt ggt ctc gcc ctg ggt tgt ggg ggc ttc ctt ctg ctg ttc gtg 432 Val Cys Gly Leu Ala Leu Gly Cys Gly Gly Phe Leu Leu Leu Phe Val 130 135 140 tgc tgg tgc ggt cgt ccg tgt ctt cct gtg gtc gct ggg agt tgg ggt 480 Cys Trp Cys Gly Arg Pro Cys Leu Pro Val Val Ala Gly Ser Trp Gly 145 150 155 160 ccc ctg ggg tcc ttt ttt tgg gcc gag cct ccc tcc ttt tgc cag tgc 528 Pro Leu Gly Ser Phe Phe Trp Ala Glu Pro Pro Ser Phe Cys Gln Cys 165 170 175 tct tgn ggt gng ttt ttt cct ttg ggc ttt gtg ggt ccc tgg tgt ggt 576 Ser Xaa Gly Xaa Phe Phe Pro Leu Gly Phe Val Gly Pro Trp Cys Gly 180 185 190 gcg ttg tgg tgc ccg tct tcc ttc tcc tgg ttg ctc tgc gcc gcc ctg 624 Ala Leu Trp Cys Pro Ser Ser Phe Ser Trp Leu Leu Cys Ala Ala Leu 195 200 205 cgg tgn tgt tct ctg tct gtc ctc gtg cct tgc ttt tgg ctt ctt gtc 672 Arg Xaa Cys Ser Leu Ser Val Leu Val Pro Cys Phe Trp Leu Leu Val 210 215 220 gtc ggc cgc tcg ctt ttg tcg ctt gtc ctt tgc tcc ccc gtt cct ccg 720 Val Gly Arg Ser Leu Leu Ser Leu Val Leu Cys Ser Pro Val Pro Pro 225 230 235 240 ttg ctt tnt tgg ttc ttt ttt tcg cgg cct gtc cgt cgt cgc tct tcc 768 Leu Leu Xaa Trp Phe Phe Phe Ser Arg Pro Val Arg Arg Arg Ser Ser 245 250 255 tct tgt ttt tgg ttt cgt tcc ggg tgt tgt ttc cgc gct cgg tcc ttc 816 Ser Cys Phe Trp Phe Arg Ser Gly Cys Cys Phe Arg Ala Arg Ser Phe 260 265 270 gcg ctt ttc ttt ttt cgt ctt tgt tcg tgg tgt cgt gct cta gtg ggc 864 Ala Leu Phe Phe Phe Arg Leu Cys Ser Trp Cys Arg Ala Leu Val Gly 275 280 285 tgt aca gtc ttg tat ata taa 885 Cys Thr Val Leu Tyr Ile 290 295 <210> 54 <211> 294 <212> PRT <213> Homo sapiens <400> 54 Met Xaa Leu Val Gly Ser Xaa Arg Ser Pro Val Ile Ser Gln Phe Ser 1 5 10 15 Leu Ser Val Thr Arg Lys Leu Ser Pro Cys Trp Leu His Cys Ile Ser 20 25 30 Lys Gln Arg Ala Val Trp His Val Lys Ala Asn Glu Glu Gly Cys Leu 35 40 45 Leu Gly Lys Asn Val Val Gly Gly Arg Ala Val Leu Cys Ser Ala Val 50 55 60 Glu Asn Ala Gly Tyr Ile His Lys Thr Phe Pro Ala Cys Gly Gly Asn 65 70 75 80 Cys Ser Thr Ala Pro Ile Ser Tyr Cys Val Leu Ser Val Gly Phe Cys 85 90 95 Leu Phe Val Leu Xaa Xaa Ser Arg Ser Ser Arg Trp Xaa Ser Pro Ile 100 105 110 Tyr Phe Cys Val Gly Val Phe Ala Leu Val Xaa Val Pro Phe Leu Val 115 120 125 Val Cys Gly Leu Ala Leu Gly Cys Gly Gly Phe Leu Leu Leu Phe Val 130 135 140 Cys Trp Cys Gly Arg Pro Cys Leu Pro Val Val Ala Gly Ser Trp Gly 145 150 155 160 Pro Leu Gly Ser Phe Phe Trp Ala Glu Pro Pro Ser Phe Cys Gln Cys 165 170 175 Ser Xaa Gly Xaa Phe Phe Pro Leu Gly Phe Val Gly Pro Trp Cys Gly 180 185 190 Ala Leu Trp Cys Pro Ser Ser Phe Ser Trp Leu Leu Cys Ala Ala Leu 195 200 205 Arg Xaa Cys Ser Leu Ser Val Leu Val Pro Cys Phe Trp Leu Leu Val 210 215 220 Val Gly Arg Ser Leu Leu Ser Leu Val Leu Cys Ser Pro Val Pro Pro 225 230 235 240 Leu Leu Xaa Trp Phe Phe Phe Ser Arg Pro Val Arg Arg Arg Ser Ser 245 250 255 Ser Cys Phe Trp Phe Arg Ser Gly Cys Cys Phe Arg Ala Arg Ser Phe 260 265 270 Ala Leu Phe Phe Phe Arg Leu Cys Ser Trp Cys Arg Ala Leu Val Gly 275 280 285 Cys Thr Val Leu Tyr Ile 290 <210> 55 <211> 903 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(903) <400> 55 atg aaa agt gct tgc aca gca aca agc aca cgg cct ggg gtg tgg ctg 48 Met Lys Ser Ala Cys Thr Ala Thr Ser Thr Arg Pro Gly Val Trp Leu 1 5 10 15 cga ggt ggg agc agg gac cct cac cat cag cac tgc aaa gta ggt caa 96 Arg Gly Gly Ser Arg Asp Pro His His Gln His Cys Lys Val Gly Gln 20 25 30 gtg gtt gca gaa gca gga tgt ttg ggt ttc tct cct gac ggg ctc aca 144 Val Val Ala Glu Ala Gly Cys Leu Gly Phe Ser Pro Asp Gly Leu Thr 35 40 45 ccc agc act gct cca atg ccc cgg gct gct cac tgt gga ggg gac agc 192 Pro Ser Thr Ala Pro Met Pro Arg Ala Ala His Cys Gly Gly Asp Ser 50 55 60 gcg ggg ctc cna tct cgt cca gtc ctc ctg gac ccc tct gtg tcc tcc 240 Ala Gly Leu Xaa Ser Arg Pro Val Leu Leu Asp Pro Ser Val Ser Ser 65 70 75 80 ccc ttt ngc tcg act gtg tca ttc ttc ctc ccg gcc ctc ctc tng cct 288 Pro Phe Xaa Ser Thr Val Ser Phe Phe Leu Pro Ala Leu Leu Xaa Pro 85 90 95 gcc gtc gct ctc tct tcg agg tgc tcc ttt ctc ctg gct gcc ctc tgt 336 Ala Val Ala Leu Ser Ser Arg Cys Ser Phe Leu Leu Ala Ala Leu Cys 100 105 110 gtt ttt cct cgc ctc ttc ccc ccc gct ggt ctc tct ttc tct tcc ccc 384 Val Phe Pro Arg Leu Phe Pro Pro Ala Gly Leu Ser Phe Ser Ser Pro 115 120 125 ttc tcg ttc tgg cct ttt gct cct gct ttc ttt cct gtg tgg tct tcg 432 Phe Ser Phe Trp Pro Phe Ala Pro Ala Phe Phe Pro Val Trp Ser Ser 130 135 140 tcc ccc gcc ccc tcc ttt gcg tct tcc tct ctt tct gct gtg gcc ctc 480 Ser Pro Ala Pro Ser Phe Ala Ser Ser Ser Leu Ser Ala Val Ala Leu 145 150 155 160 ttc gct gtg ttg gtt cgt ttg ccg cgc tgg ctg tgc ttc ccc ttt tcc 528 Phe Ala Val Leu Val Arg Leu Pro Arg Trp Leu Cys Phe Pro Phe Ser 165 170 175 cgc ttg ttg ttc ttc ttc ttt cgt ccg gtc tgc ggt gcg ctc tct ctc 576 Arg Leu Leu Phe Phe Phe Phe Arg Pro Val Cys Gly Ala Leu Ser Leu 180 185 190 gtt tgc gtc ctc tcc tgg tcc tcg ctt cgt ttc ctt cgt ccg tct ttc 624 Val Cys Val Leu Ser Trp Ser Ser Leu Arg Phe Leu Arg Pro Ser Phe 195 200 205 ccc ccn cgg ttg tgg ttg gtg gct gcc ggt ccc ggc ggt gcg tgg tgc 672 Pro Pro Arg Leu Trp Leu Val Ala Ala Gly Pro Gly Gly Ala Trp Cys 210 215 220 gcg ggt tgg cgt gcg ctg tgt tct gtt cct ttt gtg cgt tgt gct tgc 720 Ala Gly Trp Arg Ala Leu Cys Ser Val Pro Phe Val Arg Cys Ala Cys 225 230 235 240 ggc gtg tgt gtg tgc ggc gcg ttt ttg ttt tgt ttg ncg cgc cct gtc 768 Gly Val Cys Val Cys Gly Ala Phe Leu Phe Cys Leu Xaa Arg Pro Val 245 250 255 ctt cgt cct gng tgt ttg gtt tcc ttt ttc gtc aag aat aaa ata aga 816 Leu Arg Pro Xaa Cys Leu Val Ser Phe Phe Val Lys Asn Lys Ile Arg 260 265 270 gac aaa acg cta nag ctt ngc agc cct cgc cgt gcg gct cta gta gat 864 A sp Lys Thr Leu Xaa Leu Xaa Ser Pro Arg Arg Ala Ala Leu Val Asp 275 280 285 aac tat gtc tgt ccc ttc ccc agg ata aac tgg cgt tga 903 Asn Tyr Val Cys Pro Phe Pro Arg Ile Asn Trp Arg 290 295 300 <210> 56 <211> 300 <212> PRT <213> Homo sapiens <400> 56 Met Lys Ser Ala Cys Thr Ala Thr Ser Thr Arg Pro Gly Val Trp Leu 1 5 10 15 Arg Gly Gly Ser Arg Asp Pro His His Gln His Cys Lys Val Gly Gln 20 25 30 Val Val Ala Glu Ala Gly Cys Leu Gly Phe Ser Pro Asp Gly Leu Thr 35 40 45 Pro Ser Thr Ala Pro Met Pro Arg Ala Ala His Cys Gly Gly Asp Ser 50 55 60 Ala Gly Leu Xaa Ser Arg Pro Val Leu Leu Asp Pro Ser Val Ser Ser 65 70 75 80 Pro Phe Xaa Ser Thr Val Ser Phe Phe Leu Pro Ala Leu Leu Xaa Pro 85 90 95 Ala Val Ala Leu Ser Ser Arg Cys Ser Phe Leu Leu Ala Ala Leu Cys 100 105 110 Val Phe Pro Arg Leu Phe Pro Pro Ala Gly Leu Ser Phe Ser Ser Pro 115 120 125 Phe Ser Phe Trp Pro Phe Ala Pro Ala Phe Phe Pro Val Trp Ser Ser 130 135 140 Ser Pro Ala Pro Ser Phe Ala Ser Ser Ser Leu Ser Ala Val Ala Leu 145 150 155 160 Phe Ala Val Leu Val Arg Leu Pro Arg Trp Leu Cys Phe Pro Phe Ser 165 170 175 Arg Leu Leu Phe Phe Phe Phe Arg Pro Val Cys Gly Ala Leu Ser Leu 180 185 190 Val Cys Val Leu Ser Trp Ser Ser Leu Arg Phe Leu Arg Pro Ser Phe 195 200 205 Pro Pro Arg Leu Trp Leu Val Ala Ala Gly Pro Gly Gly Ala Trp Cys 210 215 220 Ala Gly Trp Arg Ala Leu Cys Ser Val Pro Phe Val Arg Cys Ala Cys 225 230 235 240 Gly Val Cys Val Cys Gly Ala Phe Leu Phe Cys Leu Xaa Arg Pro Val 245 250 255 Leu Arg Pro Xaa Cys Leu Val Ser Phe Phe Val Lys Asn Lys Ile Arg 260 265 270 Asp Lys Thr Leu Xaa Leu Xaa Ser Pro Arg Arg Ala Ala Leu Val Asp 275 280 285 Asn Tyr Val Cys Pro Phe Pro Arg Ile Asn Trp Arg 290 295 300 <210> 57 <211> 1041 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1041) <400> 57 atg gag aga aaa ttt atg tcc ttg caa cca tcc atc tcc gta tca gaa 48 Met Glu Arg Lys Phe Met Ser Leu Gln Pro Ser Ile Ser Val Ser Glu 1 5 10 15 atg gaa cca aat ggc acc ttc agc aat aac aac agc agg aac tgc aca 96 Met Glu Pro Asn Gly Thr Phe Ser Asn Asn Asn Ser Arg Asn Cys Thr 20 25 30 att gaa aac ttc aag aga gaa ttt ttc cca att gta tat ctg ata ata 144 Ile Glu Asn Phe Lys Arg Glu Phe Phe Pro Ile Val Tyr Leu Ile Ile 35 40 45 ttt ttc tgg gga gtc ttg gga aat ggg ttg tcc ata tat gtt ttc ctg 192 Phe Phe Trp Gly Val Leu Gly Asn Gly Leu Ser Ile Tyr Val Phe Leu 50 55 60 cag cct tat aag aag tcc aca tct gtg aac gtt ttc atg cta aat ctg 240 Gln Pro Tyr Lys Lys Ser Thr Ser Val Asn Val Phe Met Leu Asn Leu 65 70 75 80 gcc att tca gat ctc ctg ttc ata agc acg ctt ccc ttc agg gct gac 288 Ala Ile Ser Asp Leu Leu Phe Ile Ser Thr Leu Pro Phe Arg Ala Asp 85 90 95 tat tat ctt aga ggc tcc aat tgg ata ttt gga gac ctg gcc tgc agg 336 Tyr Tyr Leu Arg Gly Ser Asn Trp Ile Phe Gly Asp Leu Ala Cys Arg 100 105 110 att atg tct tat tcc ttg tat gtc aac atg tac agc agt att tat ttc 384 Ile Met Ser Tyr Ser Leu Tyr Val Asn Met Tyr Ser Ser Ile Tyr Phe 115 120 125 ctg acc gtg ctg agt gtt gtg cgt ttc ctg gca atg gtt cac ccc ttt 432 Leu Thr Val Leu Ser Val Val Arg Phe Leu Ala Met Val His Pro Phe 130 135 140 cgg ctt ctg cat gtc acc agc atc agg agt gcc tgg atc ctc tgt ggg 480 Arg Leu Leu His Val Thr Ser Ile Arg Ser Ala Trp Ile Leu Cys Gly 145 150 155 160 atc ata tgg atc ctt atc atg gct tcc tca ata atg ctc ctg gac agt 528 Ile Ile Trp Ile Leu Ile Met Ala Ser Ser Ile Met Leu Leu Asp Ser 165 170 175 ggc tct gag cag aac ggc agt gtc aca tca tgc tta gag ctg aat ctc 576 Gly Ser Glu Gln Asn Gly Ser Val Thr Ser Cys Leu Glu Leu Asn Leu 180 185 190 tat aaa att gct aag ctg cag acc atg aac tat att gcc ttg gtg gtg 624 Tyr Lys Ile Ala Lys Leu Gln Thr Met Asn Tyr Ile Ala Leu Val Val 195 200 205 ggc tgc ctg ctg cca ttt ttc aca ctc agc atc tgt tat ctg ctg atc 672 Gly Cys Leu Leu Pro Phe Phe Thr Leu Ser Ile Cys Tyr Leu Leu Ile 210 215 220 att cgg gtt ctg tta aaa gtg gag gtc cca gaa tcg ggg ctg cgg gtt 720 Ile Arg Val Leu Leu Lys Val Glu Val Pro Glu Ser Gly Leu Arg Val 225 230 235 240 tct cac agg aag gca ctg acc acc atc atc atc acc ttg atc atc ttc 768 Ser His Arg Lys Ala Leu Thr Thr Ile Ile Ile Thr Leu Ile Ile Phe 245 250 255 ttc ttg tgt ttc ctg ccc tat cac aca ctg agg acc gtc cac ttg acg 816 Phe Leu Cys Phe Leu Pro Tyr His Thr Leu Arg Thr Val His Leu Thr 260 265 270 aca tgg aaa gtg ggt tta tgc aaa gac aga ctg cat aaa gct ttg gtt 864 Thr Trp Lys Val Gly Leu Cys Lys Asp Arg Leu His Lys Ala Leu Val 275 280 285 atc aca ctg gcc ttg gca gca gcc aat gcc tgc ttc aat cct ctg ctc 912 Ile Thr Leu Ala Leu Ala Ala Ala Asn Ala Cys Phe Asn Pro Leu Leu 290 295 300 tat tac ttt gct ggg gag aat ttt aag gac aga cta aag tct gca ctc 960 Tyr Tyr Phe Ala Gly Glu Asn Phe Lys Asp Arg Leu Lys Ser Ala Leu 305 310 315 320 aga aaa ggc cat cca cag aag gca aag aca aag tgt gtt ttc cct gtt 1008 Arg Lys Gly His Pro Gln Lys Ala Lys Thr Lys Cys Val Phe Pro Val 325 330 335 agt gtg tgg ttg aga aag gaa aca aga gta taa 1041 Ser Val Trp Leu Arg Lys Glu Thr Arg Val 340 345 <210> 58 <211> 346 <212> PRT <21 3> Homo sapiens <400> 58 Met Glu Arg Lys Phe Met Ser Leu Gln Pro Ser Ile Ser Val Ser Glu 1 5 10 15 Met Glu Pro Asn Gly Thr Phe Ser Asn Asn Asn Ser Arg Asn Cys Thr 20 25 30 Ile Glu Asn Phe Lys Arg Glu Phe Phe Pro Ile Val Tyr Leu Ile Ile 35 40 45 Phe Phe Trp Gly Val Leu Gly Asn Gly Leu Ser Ile Tyr Val Phe Leu 50 55 60 Gln Pro Tyr Lys Lys Ser Thr Ser Val Asn Val Phe Met Leu Asn Leu 65 70 75 80 Ala Ile Ser Asp Leu Leu Phe Ile Ser Thr Leu Pro Phe Arg Ala Asp 85 90 95 Tyr Tyr Leu Arg Gly Ser Asn Trp Ile Phe Gly Asp Leu Ala Cys Arg 100 105 110 Ile Met Ser Tyr Ser Leu Tyr Val Asn Met Tyr Ser Ser Ile Tyr Phe 115 120 125 Leu Thr Val Leu Ser Val Val Arg Phe Leu Ala Met Val His Pro Phe 130 135 140 Arg Leu Leu His Val Thr Ser Ile Arg Ser Ala Trp Ile Leu Cys Gly 145 150 155 160 Ile Ile Trp Ile Leu Ile Met Ala Ser Ser Ile Met Leu Leu Asp Ser 165 170 175 Gly Ser Glu Gln Asn Gly Ser Val Thr Ser Cys Leu Glu Leu Asn Leu 180 185 190 Tyr Lys Ile Ala Lys Leu Gln Thr Met Asn Tyr Ile Ala Leu Val Val 195 200 205 Gly Cys Leu Leu Pro Phe Phe Thr Leu Ser Ile Cys Tyr Leu Leu Ile 210 215 220 Ile Arg Val Leu Leu Lys Val Glu Val Pro Glu Ser Gly Leu Arg Val 225 230 235 240 Ser His Arg Lys Ala Leu Thr Thr Ile Ile Ile Thr Leu Ile Ile Phe 245 250 255 Phe Leu Cys Phe Leu Pro Tyr His Thr Leu Arg Thr Val His Leu Thr 260 265 270 Thr Trp Lys Val Gly Leu Cys Lys Asp Arg Leu His Lys Ala Leu Val 275 280 285 Ile Thr Leu Ala Leu Ala Ala Ala Asn Ala Cys Phe Asn Pro Leu Leu 290 295 300 Tyr Tyr Phe Ala Gly Glu Asn Phe Lys Asp Arg Leu Lys Ser Ala Leu 305 310 315 320 Arg Lys Gly His Pro Gln Lys Ala Lys Thr Lys Cys Val Phe Pro Val 325 330 335 Ser Val Trp Leu Arg Lys Glu Thr Arg Val 340 345 <210> 59 <211> 1107 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1107) <400> 59 atg gcc aac tcc aca ggg ctg aac gcc tca gaa gtc gca ggc tcg ttg 48 Met Ala Asn Ser Thr Gly Leu Asn Ala Ser Glu Val Ala Gly Ser Leu 1 5 10 15 ggg ttg atc ctg gca gct gtc gtg gag gtg ggg gca ctg ctg ggc aac 96 Gly Leu Ile Leu Ala Ala Val Val Glu Val Gly Ala Leu Leu Gly Asn 20 25 30 ggc gcg ctg ctg gtc gtg gtg ctg cgc acg ccg gga ctg cgc gac gcg 144 Gly Ala Leu Leu Val Val Val Leu Arg Thr Pro Gly Leu Arg Asp Ala 35 40 45 ctc tac ctg gcg cac ctg tgc gtc gtg gac ctg ctg gcg gcc gcc tcc 192 Leu Tyr Leu Ala His Leu Cys Val Val Asp Leu Leu Ala Ala Ala Ser 50 55 60 atc atg ccg ctg ggc ctg ctg gcc gca ccg ccg ccc ggg ctg ggc cgc 240 Ile Met Pro Leu Gly Leu Leu Ala Ala Pro Pro Pro Gly Leu Gly Arg 65 70 75 80 gtg cgc ctg ggc ccc gcg cca tgc cgc gcc gct cgc ttc ctc tcc gcc 288 Val Arg Leu Gly Pro Ala Pro Cys Arg Ala Ala Arg Phe Leu Ser Ala 85 90 95 gct ctg ctg ccg gcc tgc acg ctc ggg gtg gcc gca ctt ggc ctg gca 336 Ala Leu Leu Pro Ala Cys Thr Leu Gly Val Ala Ala Leu Gly Leu Ala 100 105 110 cgc tac cgc ctc atc gtg cac ccg ctg cgg cca ggc tcg cgg ccg ccg 384 Arg Tyr Arg Leu Ile Val His Pro Leu Arg Pro Gly Ser Arg Pro Pro 115 120 125 cct gtg ctc gtg ctc acc gcc gtg tgg gcc gcg gcg gga ctg ctg ggc 432 Pro Val Leu Val Leu Thr Ala Val Trp Ala Ala Ala Gly Leu Leu Gly 130 135 140 gcg ctc tcc ctg ctc ggc ccg ccg ccc gca ccg ccc cct gct cct gct 480 Ala Leu Ser Leu Leu Gly Pro Pro Pro Ala Pro Pro Pro Ala Pro Ala 145 150 155 160 cgc tgc tcg gtc ctg gct ggg ggc ctc ggg ccc ttc cgg ccg ctc tgg 528 Arg Cys Ser Val Leu Ala Gly Gly Leu Gly Pro Phe Arg Pro Leu Trp 165 170 175 gcc ctg ctg gcc ttc gcg ctg ccc gcc ctc ctg ctg ctc ggc gcc tac 576 Ala Leu Leu Ala Phe Ala Leu Pro Ala Leu Leu Leu Leu Gly Ala Tyr 180 185 190 ggc ggc atc ttc gtg gtg gcg cgt cgc gct gcc ctg agg ccc cca cgg 624 Gly Gly Ile Phe Val Val Ala Arg Arg Ala Ala Leu Arg Pro Pro Arg 195 200 205 ccg gcg cgc ggg tcc cga ctc cgc tcg gac tct ctg gat agc cgc ctt 672 Pro Ala Arg Gly Ser Arg Leu Arg Ser Asp Ser Leu Asp Ser Arg Leu 210 215 220 tcc atc ttg ccg ccg ctc cgg cct cgc ctg ccc ggg ggc aag gcg gcc 720 Ser Ile Leu Pro Pro Leu Arg Pro Arg Leu Pro Gly Gly Lys Ala Ala 225 230 235 240 ctg gcc cca gcg ctg gcc gtg ggc caa ttt gca gcc tgc tgg ctg cct 768 Leu Ala Pro Ala Leu Ala Val Gly Gln Phe Ala Ala Cys Trp Leu Pro 245 250 255 tat ggc tgc gcg tgc ctg gcg ccc gca gcg cgg gcc gcg gaa gcc gaa 816 Tyr Gly Cys Ala Cys Leu Ala Pro Ala Ala Arg Ala Ala Glu Ala Glu 260 265 270 gcg gct gtc acc tgg gtc gcc tac tcg gcc ttc gcg gct cac ccc ttc 864 Ala Ala Val Thr Trp Val Ala Tyr Ser Ala Phe Ala Ala His Pro Phe 275 280 285 ctg tac ggg ctg ctg cag cgc ccc gtg cgc ttg gca ctg ggc cgc ctc 912 Leu Tyr Gly Leu Leu Gln Arg Pro Val Arg Leu Ala Leu Gly Arg Leu 290 295 300 tct cgc cgt gca ctg cct gga cct gtg cgg gcc tgc act ccg caa gcc 960 Ser Arg Arg Ala Leu Pro Gly Pro Val Arg Ala Cys Thr Pro Gln Ala 305 310 315 320 tgg cac ccg cgg gca ctc ttg caa tgc ctc cag aga ccc cca gag ggc 1008 Trp His Pro Arg Ala Leu Leu Gln Cys Leu Gln Arg Pro Pro Glu Gly 325 330 335 cct gcc gta ggc cct tct gag gct cca gaa cag acc ccc gag ttg gca 1056 Pro Ala Val Gly Pro Ser Glu Ala Pro Glu Gln Thr Pro Glu Leu Ala 340 345 350 gga ggg cgg agc ccc gca tac cag ggg cca cct gag agt tct ctc tcc 1104 Gly Gly Arg Ser Pro Ala Tyr Gln Gly Pro Pro Glu Ser Ser Leu Ser 355 360 365 tga 1107 <210> 60 <211> 368 <212> PRT <213> Homo sapiens <400> 60 Met Ala Asn Ser Thr Gly Leu Asn Ala Ser Glu Val Ala Gly Ser Leu 1 5 10 15 Gly Leu Ile Leu Ala Ala Val Val Glu Val Gly Ala Leu Leu Gly Asn 20 25 30 Gly Ala Leu Leu Val Val Val Leu Arg Thr Pro Gly Leu Arg Asp Ala 35 40 45 Leu Tyr Leu Ala His Leu Cys Val Val Asp Leu Leu Ala Ala Ala Ser 50 55 60 Ile Met Pro Leu Gly Leu Leu Ala Ala Pro Pro Pro Gly Leu Gly Arg 65 70 75 80 Val Arg Leu Gly Pro Ala Pro Cys Arg Ala Ala Arg Phe Leu Ser Ala 85 90 95 Ala Leu Leu Pro Ala Cys Thr Leu Gly Val Ala Ala Leu Gly Leu Ala 100 105 110 Arg Tyr Arg Leu Ile Val His Pro Leu Arg Pro Gly Ser Arg Pro Pro 115 120 125 Pro Val Leu Val Leu Thr Ala Val Trp Ala Ala Ala Gly Leu Leu Gly 130 135 140 Ala Leu Ser Leu Leu Gly Pro Pro Pro Ala Pro Pro Pro Ala Pro Ala 145 150 155 160 Arg Cys Ser Val Leu Ala Gly Gly Leu Gly Pro Phe Arg Pro Leu Trp 165 170 175 Ala Leu Leu Ala Phe Ala Leu Pro Ala Leu Leu Leu Leu Gly Ala Tyr 180 185 190 Gly Gly Ile Phe Val Val Ala Arg Arg Ala Ala Leu Arg Pro Pro Arg 195 200 205 Pro Ala Arg Gly Ser Arg Leu Arg Ser Asp Ser Leu Asp Ser Arg Leu 210 215 220 Ser Ile Leu Pro Pro Leu Arg Pro Arg Leu Pro Gly Gly Lys Ala Ala 225 230 235 240 Leu Ala Pro Ala Leu Ala Val Gly Gln Phe Ala Ala Cys Trp Leu Pro 245 250 255 Tyr Gly Cys Ala Cys Leu Ala Pro Ala Ala Arg Ala Ala Glu Ala Glu 260 265 270 Ala Ala Val Thr Trp Val Ala Tyr Ser Ala Phe Ala Ala His Pro Phe 275 280 285 Leu Tyr Gly Leu Leu Gln Arg Pro Val Arg Leu Ala Leu Gly Arg Leu 290 295 300 Ser Arg Arg Ala Leu Pro Gly Pro Val Arg Ala Cys Thr Pro Gln Ala 305 310 315 320 Trp His Pro Arg Ala Leu Leu Gln Cys Leu Gln Arg Pro Pro Glu Gly 325 330 335 Pro Ala Val Gly Pro Ser Glu Ala Pro Glu Gln Thr Pro Glu Leu Ala 340 345 350 Gly Gly Arg Ser Pro Ala Tyr Gln Gly Pro Pro Glu Ser Ser Leu Ser 355 360 365 <210> 61 <211> 702 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(702) <400> 61 atg gag ccc aat gct acg ttc acc acg cag ctc acg gcc aca cct gag 48 Met Glu Pro Asn Ala Thr Phe Thr Thr Gln Leu Thr Ala Thr Pro Glu 1 5 10 15 cga ctg ctc cga ctc atc tct gct ggg gtc tgt ggc ctc atc ctg ctg 96 Arg Leu Leu Arg Leu Ile Ser Ala Gly Val Cys Gly Leu Ile Leu Leu 20 25 30 gtg ggg ctg tca gct aat ggg ctc atg ctg ctg gtg gtg ggc cgg ggc 144 Val Gly Leu Ser Ala Asn Gly Leu Met Leu Leu Val Val Gly Arg Gly 35 40 45 ccg ggc tcc ccc cac ccg ctc cac tcc ctg acc cac agc ctc atg atg 192 Pro Gly Ser Pro His Pro Leu His Ser Leu Thr His Ser Leu Met Met 50 55 60 aac atc acg cca tct gac ctg ctc ttc ctg gcc tgc gtg gtg cct gtg 240 Asn Ile Thr Pro Ser Asp Leu Leu Phe Leu Ala Cys Val Val Pro Val 65 70 75 80 ctg ctg ctg agc ttc ctg cag cac aac tgg tgg ctg ggc cct gcc atc 288 Leu Leu Leu Ser Phe Leu Gln His Asn Trp Trp Leu Gly Pro Ala Ile 85 90 95 tgc acc att agc cag gcc acc aac aca gcc acc acg ttc tgc atc ttc 336 Cys Thr Ile Ser Gln Ala Thr Asn Thr Ala Thr Thr Phe Cys Ile Phe 100 105 110 tat agc atg gtg gcc aca gct ctc ctg cgc cat gtg gct gtg gcc cgg 384 Tyr Ser Met Val Ala Thr Ala Leu Leu Arg His Val Ala Val Ala Arg 115 120 125 cct gac ctg gcc ttc cca gcc ggc tgg ggc acc ctc ttg ctg ctc tgt 432 Pro Asp Leu Ala Phe Pro Ala Gly Trp Gly Thr Leu Leu Leu Leu Cys 130 135 140 ggg gcc atg tgg gcc ctg ggc ctt aca gaa tcc ctg ccc aac tgg ctg 480 Gly Ala Met Trp Ala Leu Gly Leu Thr Glu Ser Leu Pro Asn Trp Leu 145 150 155 160 ttc cag agg gtg gca gtg gag gag gag aca gcg ggg gct ccc aag acc 528 Phe Gln Arg Val Ala Val Glu Glu Glu Thr Ala Gly Ala Pro Lys Thr 165 170 175 cag gcc tgc ctc ttg ctc ctg agc cct gct ggg acc tcc tgc tac atc 576 Gln Ala Cys Leu Leu Leu Leu Ser Pro Ala Gly Thr Ser Cys Tyr Ile 180 185 190 agc ctg ctg gga gcc ctg gcc ttc ctg cca tgc acg ctg ggg ctg ggc 624 Ser Leu Leu Gly Ala Leu Ala Phe Leu Pro Cys Thr Leu Gly Leu Gly 195 200 205 tgc tct ttc agc cac gtg ggc tgg ctc ctg tgg acc cag ccc caa ggt 672 Cys Ser Phe Ser His Val Gly Trp Leu Leu Trp Thr Gln Pro Gln Gly 210 215 220 ccc atg gga gag agc atc cag gag cat taa 702 Pro Met Gly Glu Ser Ile Gln Glu His 225 230 <210> 62 <211> 233 <212> PRT <213> Homo sapiens <400> 62 Met Glu Pro Asn Ala Thr Phe Thr Thr Gln Leu Thr Ala Thr Pro Glu 1 5 10 15 Arg Leu Leu Arg Leu Ile Ser Ala Gly Val Cys Gly Leu Ile Leu Leu 20 25 30 Val Gly Leu Ser Ala Asn Gly Leu Met Leu Leu Val Val Gly Arg Gly 35 40 45 Pro Gly Ser Pro His Pro Leu His Ser Leu Thr His Ser Leu Met Met 50 55 60 Asn Ile Thr Pro Ser Asp Leu Leu Phe Leu Ala Cys Val Val Pro Val 65 70 75 80 Leu Leu Leu Ser Phe Leu Gln His Asn Trp Trp Leu Gly Pro Ala Ile 85 90 95 Cys Thr Ile Ser Gln Ala Thr Asn Thr Ala Thr Thr Phe Cys Ile Phe 100 105 110 Tyr Ser Met Val Ala Thr Ala Leu Leu Arg His Val Ala Val Ala Arg 115 120 125 Pro Asp Leu Ala Phe Pro Ala Gly Trp Gly Thr Leu Leu Leu Leu Cys 130 135 140 Gly Ala Met Trp Ala Leu Gly Leu Thr Glu Ser Leu Pro Asn Trp Leu 145 150 155 160 Phe Gln Arg Val Ala Val Glu Glu Glu Thr Ala Gly Ala Pro Lys Thr 165 170 175 Gln Ala Cys Leu Leu Leu Leu Ser Pro Ala Gly Thr Ser Cys Tyr Ile 180 185 190 Ser Leu Leu Gly Ala Leu Ala Phe Leu Pro Cys Thr Leu Gly Leu Gly 195 200 205 Cys Ser Phe Ser His Val Gly Trp Leu Leu Trp Thr Gln Pro Gln Gly 210 215 220 Pro Met Gly Glu Ser Ile Gln Glu His 225 230 <210> 63 <211> 1188 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1188) <400> 63 atg act cac act ctt tac cct acc cct ttt gct ttg tat cca ata aat 48 Met Thr His Thr Leu Tyr Pro Thr Pro Phe Ala Leu Tyr Pro Ile Asn 1 5 10 15 atc agc gca gcc tgg cat ttg ggg cca cta cca gtc tcc tgc ttt gta 96 Ile Ser Ala Ala Trp His Leu Gly Pro Leu Pro Val Ser Cys Phe Val 20 25 30 tcc aat aaa tat cag cgc agc ctg gca ttc ggg gcc act acc ggt ctc 144 Ser Asn Lys Tyr Gln Arg Ser Leu Ala Phe Gly Ala Thr Thr Gly Leu 35 40 45 cgc gtc ttg gtg gta gtg gtc ccc cag aca cag ctg tct ttt ctt tca 192 Arg Val Leu Val Val Val Val Pro Gln Thr Gln Leu Ser Phe Leu Ser 50 55 60 tct ctt tgt ctt gtg tct tta ttt cta cac tct ctt gtc tct gca cac 240 Ser Leu Cys Leu Val Ser Leu Phe Leu His Ser Leu Val Ser Ala His 65 70 75 80 gga gag aaa ccc acc aaa cct gtg ggg ctg gac cct aca cta ttc cag 288 Gly Glu Lys Pro Thr Lys Pro Val Gly Leu Asp Pro Thr Leu Phe Gln 85 90 95 gta gtt gtt gga atc ctg ggg aat ttt tca ctc tta tat tat tat atg 336 Val Val Val Gly Ile Leu Gly Asn Phe Ser Leu Leu Tyr Tyr Tyr Met 100 105 110 ttc ctt tac ttt agg gga tac aag cca aga tcc aca gat ttg att ctc 384 Phe Leu Tyr Phe Arg Gly Tyr Lys Pro Arg Ser Thr Asp Leu Ile Leu 115 120 125 agg cac ctg act gta gct gac tcc ttg gtt atc cta tct aaa aga atc 432 Arg His Leu Thr Val Ala Asp Ser Leu Val Ile Leu Ser Lys Arg Ile 130 135 140 cca gag acc atg gca act ttt ggg ttg aaa cat ttt gac aat tat ttt 480 Pro Glu Thr Met Ala Thr Phe Gly Leu Lys His Phe Asp Asn Tyr Phe 145 150 155 160 gga tgc aaa ttt ctt ttg tat gca cac agg gta ggc agg ggt gtg tcc 528 Gly Cys Lys Phe Leu Leu Tyr Ala His Arg Val Gly Arg Gly Val Ser 165 170 175 att gga agc acc tgc ctc ttg agt gtc ttc cag gtg atc acc atc aac 576 Ile Gly Ser Thr Cys Leu Leu Ser Val Phe Gln Val Ile Thr Ile Asn 180 185 190 cct agg aac tcc agg tgg gca gag atg aaa gta aaa gcc ccg aca tac 624 Pro Arg Asn Ser Arg Trp Ala Glu Met Lys Val Lys Ala Pro Thr Tyr 195 200 205 att ggt ctc tcc aat atc ctg tgc tgg gcc ttc cac atg ctg gta aat 672 Ile Gly Leu Ser Asn Ile Leu Cys Trp Ala Phe His Met Leu Val Asn 210 215 220 gcc att ttt cct att tat aca act ggc aaa tgg agc aac aac aac atc 720 Ala Ile Phe Pro Ile Tyr Thr Thr Gly Lys Trp Ser Asn Asn Asn Ile 225 230 235 240 aca aag aaa gga gat ttg gga tat tgt tct gcc cca ctt agt gat gaa 768 Thr Lys Lys Gly Asp Leu Gly Tyr Cys Ser Ala Pro Leu Ser Asp Glu 245 250 255 gtc aca aag tca gta tat gca gca ttg aca tcc ttc cat gat gtt ttg 816 Val Thr Lys Ser Val Tyr Ala Ala Leu Thr Ser Phe His Asp Val Leu 260 265 270 tgt ctg ggg ctc atg ctc tgg gcc agc agc tcc atc gtt ttg gtc ttg 864 Cys Leu Gly Leu Met Leu Trp Ala Ser Ser Ser Ile Val Leu Val Leu 275 280 285 tac agg cac aaa cag cag gta caa cac atc tgt agg aac aat ctc tac 912 Tyr Arg His Lys Gln Gln Val Gln His Ile Cys Arg Asn Asn Leu Tyr 290 295 300 ccc aac tct tct cct ggg aac aga gcc atc caa agc atc ctt gca ttg 960 Pro Asn Ser Ser Pro Gly Asn Arg Ala Ile Gln Ser Ile Leu Ala Leu 305 310 315 320 gtg agc acc ttt gca tta tgt tac gcc ctt tcc ttc atc acc tac gtt 1008 Val Ser Thr Phe Ala Leu Cys Tyr Ala Leu Ser Phe Ile Thr Tyr Val 325 330 335 tat tta gct ctc ttc gat aat tcc agt tgg tgg cta gtg aac act gct 1056 Tyr Leu Ala Leu Phe Asp Asn Ser Ser Trp Trp Leu Val Asn Thr Ala 340 345 350 gca cta atc att gcc tgt ttt cca act att agc cct ttt gtt ctc atg 1104 Ala Leu Ile Ile Ala Cys Phe Pro Thr Ile Ser Pro Phe Val Leu Met 355 360 365 tgc cgt gac ccc agc aga tcc agg ctc tgc agt atc tgc tgc aga aga 1152 Cys Arg Asp Pro Ser Arg Ser Arg Leu Cys Ser Ile Cys Cys Arg Arg 370 375 380 aat aga cga ttc ttt cat gat ttc agg aaa atg tga 1188 Asn Arg Arg Phe Phe His Asp Phe Arg Lys Met 385 390 395 <210> 64 <211> 395 <212> PRT <213> Homo sapiens <400> 64 Met Thr His Thr Leu Tyr Pro Thr Pro Phe Ala Leu Tyr Pro Ile Asn 1 5 10 15 Ile Ser Ala Ala Trp His Leu Gly Pro Leu Pro Val Ser Cys Phe Val 20 25 30 Ser Asn Lys Tyr Gln Arg Ser Leu Ala Phe Gly Ala Thr Thr Gly Leu 35 40 45 Arg Val Leu Val Val Val Val Pro Gln Thr Gln Leu Ser Phe Leu Ser 50 55 60 Ser Leu Cys Leu Val Ser Leu Phe Leu His Ser Leu Val Ser Ala His 65 70 75 80 Gly Glu Lys Pro Thr Lys Pro Val Gly Leu Asp Pro Thr Leu Phe Gln 85 90 95 Val Val Val Gly Ile Leu Gly Asn Phe Ser Leu Leu Tyr Tyr Tyr Met 100 105 110 Phe Leu Tyr Phe Arg Gly Tyr Lys Pro Arg Ser Thr Asp Leu Ile Leu 115 120 125 Arg His Leu Thr Val Ala Asp Ser Leu Val Ile Leu Ser Lys Arg Ile 130 135 140 Pro Glu Thr Met Ala Thr Phe Gly Leu Lys His Phe Asp Asn Tyr Phe 145 150 155 160 Gly Cys Lys Phe Leu Leu Tyr Ala His Arg Val Gly Arg Gly Val Ser 165 170 175 Ile Gly Ser Thr Cys Leu Leu Ser Val Phe Gln Val Ile Thr Ile Asn 180 185 190 Pro Arg Asn Ser Arg Trp Ala Glu Met Lys Val Lys Ala Pro Thr Tyr 195 200 205 Ile Gly Leu Ser Asn Ile Leu Cys Trp Ala Phe His Met Leu Val Asn 210 215 220 Ala Ile Phe Pro Ile Tyr Thr Thr Gly Lys Trp Ser Asn Asn Asn Ile 225 230 235 240 Thr Lys Lys Gly Asp Leu Gly Tyr Cys Ser Ala Pro Leu Ser Asp Glu 245 250 255 Val Thr Lys Ser Val Tyr Ala Ala Leu Thr Ser Phe His Asp Val Leu 260 265 270 Cys Leu Gly Leu Met Leu Trp Ala Ser Ser Ser Ile Val Leu Val Leu 275 280 285 Tyr Arg His Lys Gln Gln Val Gln His Ile Cys Arg Asn Asn Leu Tyr 290 295 300 Pro Asn Ser Ser Pro Gly Asn Arg Ala Ile Gln Ser Ile Leu Ala Leu 305 310 315 320 Val Ser Thr Phe Ala Leu Cys Tyr Ala Leu Ser Phe Ile Thr Tyr Val 325 330 335 Tyr Leu Ala Leu Phe Asp Asn Ser Ser Trp Trp Leu Val Asn Thr Ala 340 345 350 Ala Leu Ile Ile Ala Cys Phe Pro Thr Ile Ser Pro Phe Val Leu Met 355 360 365 Cys Arg Asp Pro Ser Arg Ser Arg Leu Cys Ser Ile Cys Cys Arg Arg 370 375 380 Asn Arg Arg Phe Phe His Asp Phe Arg Lys Met 385 390 395 <210> 65 <211> 1173 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1173) <400> 65 atg cgt tct atg ttc tgg tgt att gag agg agg gtt agg gtt cac ccc 48 Met Arg Ser Met Phe Trp Cys Ile Glu Arg Arg Val Arg Val His Pro 1 5 10 15 act tgc agc tct tcg gaa gaa gag tcg tgt atg tcc cac agc tgg gag 96 Thr Cys Ser Ser Ser Glu Glu Glu Ser Cys Met Ser His Ser Trp Glu 20 25 30 ttc tct aag gtg aga gaa cct cca act tgg agt tct ctg ggg cca gaa 144 Phe Ser Lys Val Arg Glu Pro Pro Thr Trp Ser Ser Leu Gly Pro Glu 35 40 45 aca ggg tca gcc tcc ctt aga ctg gga gtt ttc cga ggg caa ggg cca 192 Thr Gly Ser Ala Ser Leu Arg Leu Gly Val Phe Arg Gly Gln Gly Pro 50 55 60 tgt tca tct ctt ttg att gga aat tct ctg aat aca gag gct gac ctt 240 Cys Ser Ser Leu Leu Ile Gly Asn Ser Leu Asn Thr Glu Ala Asp Leu 65 70 75 80 ggt cct gaa gac ctg gtc cca cca tcc tct ggc cca ggg tta atg tct 288 Gly Pro Glu Asp Leu Val Pro Pro Ser Ser Gly Pro Gly Leu Met Ser 85 90 95 gat ctc tct aca ggc ccc ttc aag ccc tgt gag tac ctc ttt gaa agc 336 Asp Leu Ser Thr Gly Pro Phe Lys Pro Cys Glu Tyr Leu Phe Glu Ser 100 105 110 tgg ggc atc cgc ctg gcc gtg tgg gcc atc gtg ttg ctc tcc gtg ctc 384 Trp Gly Ile Arg Leu Ala Val Trp Ala Ile Val Leu Leu Ser Val Leu 115 120 125 tgc aat gga ctg gtg ctg ctg acc gtg ttc gct ggc ggg cct gtc ccc 432 Cys Asn Gly Leu Val Leu Leu Thr Val Phe Ala Gly Gly Pro Val Pro 130 135 140 ctg ccc ccg gtc aag ttt gtg gta ggt gcg att gca ggc gcc aac acc 480 Leu Pro Pro Val Lys Phe Val Val Gly Ala Ile Ala Gly Ala Asn Thr 145 150 155 160 ttg act ggc att tcc tgt ggc ctt cta gcc tca gtc gat gcc ctg acc 528 Leu Thr Gly Ile Ser Cys Gly Leu Leu Ala Ser Val Asp Ala Leu Thr 165 170 175 ttt ggt cag ttc tct gag tac gga gcc cgc tgg gag acg ggg cta ggc 576 Phe Gly Gln Phe Ser Glu Tyr Gly Ala Arg Trp Glu Thr Gly Leu Gly 180 185 190 tgc cgg gcc act ggc ttc ctg gca gta ctt ggg tcg gag gca tcg gtg 624 Cys Arg Ala Thr Gly Phe Leu Ala Val Leu Gly Ser Glu Ala Ser Val 195 200 205 ctg ctg ctc act ctg gcc gca gtg cag tgc agc gtc tcc gtc tcc tgt 672 Leu Leu Leu Thr Leu Ala Ala Val Gln Cys Ser Val Ser Val Ser Cys 210 215 220 gtc cgg gcc tat ggg aag tcc ccc tcc ctg ggc agc gtt cga gca ggg 720 Val Arg Ala Tyr Gly Lys Ser Pro Ser Leu Gly Ser Val Arg Ala Gly 225 230 235 240 gtc cta ggc tgc ctg gca ctg gca ggg ctg gcc gcc gcg ctg ccc ctg 768 Val Leu Gly Cys Leu Ala Leu Ala Gly Leu Ala Ala Ala Leu Pro Leu 245 250 255 gcc tca gtg gga gaa tac ggg gcc tcc cca ctc tgc ctg ccc tac gcg 816 Ala Ser Val Gly Glu Tyr Gly Ala Ser Pro Leu Cys Leu Pro Tyr Ala 260 265 270 cca cct gag ggt cag cca gca gcc ctg gga ttc acc gtg gcc ctg gtg 864 Pro Pro Glu Gly Gln Pro Ala Ala Leu Gly Phe Thr Val Ala Leu Val 275 280 285 atg atg aac tca ttc tgt ttt ctg gtt gtg gcc ggt gcc tac atc aaa 912 Met Met Asn Ser Phe Cys Phe Leu Val Val Ala Gly Ala Tyr Ile Lys 290 295 300 gag tat tgt gac atg acg cgg gcc gac ttt gag gcc gtg tgg gac tgc 960 Glu Tyr Cys Asp Met Thr Arg Ala Asp Phe Glu Ala Val Trp Asp Cys 305 310 315 320 gcc atg gtc agg caa gtg acc tgg ctc atc ttc gca atc ggg ctc ctc 1008 Ala Met Val Arg Gln Val Thr Trp Leu Ile Phe Ala Ile Gly Leu Leu 325 330 335 cag tgt acg gtg aca atc ccc agc tct gcc tcc atg gtt ggc ctc tcc 1056 Gln Cys Thr Val Thr Ile Pro Ser Ser Ala Ser Met Val Gly Leu Ser 340 345 350 cct atc acg ccg gan nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 1104 Pro Ile Thr Pro Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 355 360 365 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 1152 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 370 375 380 nnn nnn nnn nnn nnn nnn tga 1173 Xaa Xaa Xaa Xaa Xaa Xaa 385 390 <210> 66 <211> 390 <212> PRT <213> Homo sapiens <400> 66 Met Arg Ser Met Phe Trp Cys Ile Glu Arg Arg Val Arg Val His Pro 1 5 10 15 Thr Cys Ser Ser Ser Glu Glu Glu Ser Cys Met Ser His Ser Trp Glu 20 25 30 Phe Ser Lys Val Arg Glu Pro Pro Thr Trp Ser Ser Leu Gly Pro Glu 35 40 45 Thr Gly Ser Ala Ser Leu Arg Leu Gly Val Phe Arg Gly Gln Gly Pro 50 55 60 Cys Ser Ser Leu Leu Ile Gly Asn Ser Leu Asn Thr Glu Ala Asp Leu 65 70 75 80 Gly Pro Glu Asp Leu Val Pro Pro Ser Ser Gly Pro Gly Leu Met Ser 85 90 95 Asp Leu Ser Thr Gly Pro Phe Lys Pro Cys Glu Tyr Leu Phe Glu Ser 100 105 110 Trp Gly Ile Arg Leu Ala Val Trp Ala Ile Val Leu Leu Ser Val Leu 115 120 125 Cys Asn Gly Leu Val Leu Leu Thr Val Phe Ala Gly Gly Pro Val Pro 130 135 140 Leu Pro Pro Val Lys Phe Val Val Gly Ala Ile Ala Gly Ala Asn Thr 145 150 155 160 Leu Thr Gly Ile Ser Cys Gly Leu Leu Ala Ser Val Asp Ala Leu Thr 165 170 175 Phe Gly Gln Phe Ser Glu Tyr Gly Ala Arg Trp Glu Thr Gly Leu Gly 180 185 190 Cys Arg Ala Thr Gly Phe Leu Ala Val Leu Gly Ser Glu Ala Ser Val 195 200 205 Leu Leu Leu Thr Leu Ala Ala Val Gln Cys Ser Val Ser Val Ser Cys 210 215 220 Val Arg Ala Tyr Gly Lys Ser Pro Ser Leu Gly Ser Val Arg Ala Gly 225 230 235 240 Val Leu Gly Cys Leu Ala Leu Ala Gly Leu Ala Ala Ala Leu Pro Leu 245 250 255 Ala Ser Val Gly Glu Tyr Gly Ala Ser Pro Leu Cys Leu Pro Tyr Ala 260 265 270 Pro Pro Glu Gly Gln Pro Ala Ala Leu Gly Phe Thr Val Ala Leu Val 275 280 285 Met Met Asn Ser Phe Cys Phe Leu Val Val Ala Gly Ala Tyr Ile Lys 290 295 300 Glu Tyr Cys Asp Met Thr Arg Ala Asp Phe Glu Ala Val Trp Asp Cys 305 310 315 320 Ala Met Val Arg Gln Val Thr Trp Leu Ile Phe Ala Ile Gly Leu Leu 325 330 335 Gln Cys Thr Val Thr Ile Pro Ser Ser Ala Ser Met Val Gly Leu Ser 340 345 350 Pr o Ile Thr Pro Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 355 360 365 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 370 375 380 Xaa Xaa Xaa Xaa Xaa Xaa 385 390 <210> 67 <211> 1425 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1425) <400> 67 atg tct tcc gcc ccc ctc cac ctc cct ccc tct ctt aca cac aca ttt 48 Met Ser Ser Ala Pro Leu His Leu Pro Pro Ser Leu Thr His Thr Phe 1 5 10 15 gcc ccc gcc gat gtc gct tct cgc acg ggt gca cct gtg tgt gtg ccc 96 A la Pro Ala Asp Val Ala Ser Arg Thr Gly Ala Pro Val Cys Val Pro 20 25 30 cgg atg tac tca tat ctt gtt ctc ctt cgc ttc gtg ttg tac ttg ggg 144 Arg Met Tyr Ser Tyr Leu Val Leu Leu Arg Phe Val Leu Tyr Leu Gly 35 40 45 ttt cac gtt cat tgg cca gca ctt cgt aac ggc cgt gta gct gtg ttc 192 Phe His Val His Trp Pro Ala Leu Arg Asn Gly Arg Val Ala Val Phe 50 55 60 tca ccc cct tcc ttt cct ctc cgc cga att ctg ccg cct ttt cgg agc 240 Ser Pro Pro Ser Phe Pro Leu Arg Arg Ile Leu Pro Pro Phe Arg Ser 65 70 75 80 gtc ttt tct tca ccc cct ccg cac gcg tgc acc ctc gac gtg cat gtc 288 Val Phe Ser Ser Pro Pro Pro His Ala Cys Thr Leu Asp Val His Val 85 90 95 tcc gtc tcc gtg tgt gta tgt atg ctt gct gcc gta tac ctt ttt ctc 336 Ser Val Ser Val Cys Val Cys Met Leu Ala Ala Val Tyr Leu Phe Leu 100 105 110 tct tgc ctg cac gta ctc atc gtc acg cgc ctg gag cga acc gcc aga 384 Ser Cys Leu His Val Leu Ile Val Thr Arg Leu Glu Arg Thr Ala Arg 115 120 125 ggc aca tct gca aaa tac cga aca aaa acg aaa aga tac cag cag tac 432 Gly Thr Ser Ala Lys Tyr Arg Thr Lys Thr Lys Arg Tyr Gln Gln Tyr 130 135 140 aag ccg tgc gct tat aga tgg tgc acg agg agg cga gcg gtg ggc ggg 480 Lys Pro Cys Ala Tyr Arg Trp Cys Thr Arg Arg Arg Ala Val Gly Gly 145 150 155 160 cga gga ggt gcg tgt ggt tgt tgt tgc ctc tcg cct cct gct gtt gtt 528 Arg Gly Gly Ala Cys Gly Cys Cys Cys Leu Ser Pro Pro Ala Val Val 165 170 175 tcc ata ctc ttc tca ttc tcg cct gcc cta ctc tcc tcg ccc gcc acg 576 Ser Ile Leu Phe Ser Phe Ser Pro Ala Leu Leu Ser Ser Pro Ala Thr 180 185 190 acc gcg ggg ctt gag tgt tgc cac aaa ccg cag ggg acg ctt tcc tcc 624 Thr Ala Gly Leu Glu Cys Cys His Lys Pro Gln Gly Thr Leu Ser Ser 195 200 205 ctg ctt ctg tct cac cac ggg cgt acc gcg ccg cgg ttt ctt gtc acg 672 Leu Leu Leu Ser His His Gly Arg Thr Ala Pro Arg Phe Leu Val Thr 210 215 220 tgg ctg gac atc cgc agc gcg cat aca acg gct cgg gga gag agt gac 720 Trp Leu Asp Ile Arg Ser Ala His Thr Thr Ala Arg Gly Glu Ser Asp 225 230 235 240 atg ctc tat acc gcc cgg cta cat ata tgt gcg ctt cac ggg tgg agt 768 Met Leu Tyr Thr Ala Arg Leu His Ile Cys Ala Leu His Gly Trp Ser 245 250 255 ctc tcg cca agt cct ccc cat cta ctg atg cat acc tct ctc tct ctt 816 Leu Ser Pro Ser Pro Pro His Leu Leu Met His Thr Ser Leu Ser Leu 260 265 270 tgt gtg tgt gtg tgt gtg tgt gtg tct cat gtg tca cac ggg aac gcc 864 Cys Val Cys Val Cys Val Cys Val Ser His Val Ser His Gly Asn Ala 275 280 285 cca atg tgg cgt ggg ggc atc atc act ttc tcc tgc ctc ctc ctc ttg 912 Pro Met Trp Arg Gly Gly Ile Ile Thr Phe Ser Cys Leu Leu Leu Leu 290 295 300 cgc ctc gcg atc gat gga agg caa ata gaa acg cgt gtt ttc tcc tct 960 Arg Leu Ala Ile Asp Gly Arg Gln Ile Glu Thr Arg Val Phe Ser Ser 305 310 315 320 tgg cgc gcg gtg tgc aac cga aga aga gca cgt ccg tac gcc ctc ctc 1008 Trp Arg Ala Val Cys Asn Arg Arg Arg Ala Arg Pro Tyr Ala Leu Leu 325 330 335 gcg tct gct cac tcc gag acg ctc acg cgt gcg tgt ttg atc tac cgt 1056 Ala Ser Ala His Ser Glu Thr Leu Thr Arg Ala Cys Leu Ile Tyr Arg 340 345 350 cgc agc act gta cgt ggg cgt ttc tgt ctt tcc ctt ttt ttt cgt tgt 1104 Arg Ser Thr Val Arg Gly Arg Phe Cys Leu Ser Leu Phe Phe Arg Cys 355 360 365 tcc gct tgg ctc acc atg cat cgc agt ttt gtg cgc tgc agc tcc att 1152 Ser Ala Trp Leu Thr Met His Arg Ser Phe Val Arg Cys Ser Ser Ile 370 375 380 ttc cac tcc aaa gga gcg gcc gat gaa tgg ttc ggc cgc act acc tcc 1200 Phe His Ser Lys Gly Ala Ala Asp Glu Trp Phe Gly Arg Thr Thr Ser 385 390 395 400 gcg acc aca tgg cga ggc gcc ttc acc tcc ttt gcc ttg tgc ctg ctc 1248 Ala Thr Thr Trp Arg Gly Ala Phe Thr Ser Phe Ala Leu Cys Leu Leu 405 410 415 ggc att gcc gtc att aac cag ttc tgc cgc ggc aac ccc atg ggg cgg 1296 Gly Ile Ala Val Ile Asn Gln Phe Cys Arg Gly Asn Pro Met Gly Arg 420 425 430 tgc gag tac gaa aac gag atc gtg atg ccg ctg cag cga acc tgg ttg 1344 Cys Glu Tyr Glu Asn Glu Ile Val Met Pro Leu Gln Arg Thr Trp Leu 435 440 445 ccg ccg ccg gac acc cac gga ttt gtc gat gct gag tcg gag gag gga 1392 Pro Pro Pro Asp Thr His Gly Phe Val Asp Ala Glu Ser Glu Glu Gly 450 455 460 agg cag aag ccg ccg cct gta cct cga cgt tga 1425 Arg Gln Lys Pro Pro Pro Val Pro Arg Arg 465 470 475 <210> 68 <211> 474 <212> PRT <213> Homo sapiens <400> 68 Met Ser Ser Ala Pro Leu His Leu Pro Pro Ser Leu Thr His Thr Phe 1 5 10 15 Ala Pro Ala Asp Val Ala Ser Arg Thr Gly Ala Pro Val Cys Val Pro 20 25 30 Arg Met Tyr Ser Tyr Leu Val Leu Leu Arg Phe Val Leu Tyr Leu Gly 35 40 45 Phe His Val His Trp Pro Ala Leu Arg Asn Gly Arg Val Ala Val Phe 50 55 60 Ser Pro Pro Ser Phe Pro Leu Arg Arg Ile Leu Pro Pro Phe Arg Ser 65 70 75 80 Val Phe Ser Ser Pro Pro Pro His Ala Cys Thr Leu Asp Val His Val 85 90 95 Ser Val Ser Val Cys Val Cys Met Leu Ala Ala Val Tyr Leu Phe Leu 100 105 110 Ser Cys Leu His Val Leu Ile Val Thr Arg Leu Glu Arg Thr Ala Arg 115 120 125 Gly Thr Ser Ala Lys Tyr Arg Thr Lys Thr Lys Arg Tyr Gln Gln Tyr 130 135 140 Lys Pro Cys Ala Tyr Arg Trp Cys Thr Arg Arg Arg Ala Val Gly Gly 145 150 155 160 Arg Gly Gly Ala Cys Gly Cys Cys Cys Leu Ser Pro Pro Ala Val Val 165 170 175 Ser Ile Leu Phe Ser Phe Ser Pro Ala Leu Leu Ser Ser Pro Ala Thr 180 185 190 Thr Ala Gly Leu Glu Cys Cys His Lys Pro Gln Gly Thr Leu Ser Ser 195 200 205 Leu Leu Leu Ser His His Gly Arg Thr Ala Pro Arg Phe Leu Val Thr 210 215 220 Trp Leu Asp Ile Arg Ser Ala His Thr Thr Ala Arg Gly Glu Ser Asp 225 230 235 240 Met Leu Tyr Thr Ala Arg Leu His Ile Cys Ala Leu His Gly Trp Ser 245 250 255 Leu Ser Pro Ser Pro Pro His Leu Leu Met His Thr Ser Leu Ser Leu 260 265 270 Cys Val Cys Val Cys Val Cys Val Ser His Val Ser His Gly Asn Ala 275 280 285 Pro Met Trp Arg Gly Gly Ile Ile Thr Phe Ser Cys Leu Leu Leu Leu 290 295 300 Arg Leu Ala Ile Asp Gly Arg Gln Ile Glu Thr Arg Val Phe Ser Ser 305 310 315 320 Trp Arg Ala Val Cys Asn Arg Arg Arg Ala Arg Pro Tyr Ala Leu Leu 325 330 335 Ala Ser Ala His Ser Glu Thr Leu Thr Arg Ala Cys Leu Ile Tyr Arg 340 345 350 Arg Ser Thr Val Arg Gly Arg Phe Cys Leu Ser Leu Phe Phe Arg Cys 355 360 365 Ser Ala Trp Leu Thr Met His Arg Ser Phe Val Arg Cys Ser Ser Ile 370 375 380 Phe His Ser Lys Gly Ala Ala Asp Glu Trp Phe Gly Arg Thr Thr Ser 385 390 395 400 Ala Thr Thr Trp Arg Gly Ala Phe Thr Ser Phe Ala Leu Cys Leu Leu 405 410 415 Gly Ile Ala Val Ile Asn Gln Phe Cys Arg Gly Asn Pro Met Gly Arg 420 425 430 Cys Glu Tyr Glu Asn Glu Ile Val Met Pro Leu Gln Arg Thr Trp Leu 435 440 445 Pro Pro Pro Asp Thr His Gly Phe Val Asp Ala Glu Ser Glu Glu Gly 450 455 460 Arg Gln Lys Pro Pro Pro Val Pro Arg Arg 465 470 <210> 69 <211> 1074 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1074) <400> 69 atg ttg aaa ttg gtt att att gag aac atg gca gaa att atg cta ttc 48 Met Leu Lys Leu Val Ile Ile Glu Asn Met Ala Glu Ile Met Leu Phe 1 5 10 15 tca tta gat ctc ttg ctt ttc tcc aca gat atc ctt tgc ttt aat ttt 96 Ser Leu Asp Leu Leu Leu Phe Ser Thr Asp Ile Leu Cys Phe Asn Phe 20 25 30 cct tct aag atg atc aaa ctt cct ggt ttt att acc ata caa atc ttc 144 Pro Ser Lys Met Ile Lys Leu Pro Gly Phe Ile Thr Ile Gln Ile Phe 35 40 45 ttt tat cca caa gcc agc ttt gga att tca gca aac acc atc ctt ctt 192 Phe Tyr Pro Gln Ala Ser Phe Gly Ile Ser Ala Asn Thr Ile Leu Leu 50 55 60 ctt tac cac atc ttc acc ttt gtt ttc agt cac agg tct aag tcc att 240 Le u Tyr His Ile Phe Thr Phe Val Phe Ser His Arg Ser Lys Ser Ile 65 70 75 80 gac atg ata att agt cac ctg tct ctc atc cac ata ctg ctg ctc ttc 288 Asp Met Ile Ile Ser His Leu Ser Leu Ile His Ile Leu Leu Leu Phe 85 90 95 act cag gca ata ttg gtg tcc tta gac ttc ttt ggt tca cag aat act 336 Thr Gln Ala Ile Leu Val Ser Leu Asp Phe Phe Gly Ser Gln Asn Thr 100 105 110 cag gat gat ctt agg tat aag gtc att gtc ttt tta aac aag gtg atg 384 Gln Asp Asp Leu Arg Tyr Lys Val Ile Val Phe Leu Asn Lys Val Met 115 120 125 agg ggc ctc tcc atc tgc acc ccc tgc ctc ctg agt gtg ctc cag gcc 432 Arg Gly Leu Ser Ile Cys Thr Pro Cys Leu Leu Ser Val Leu Gln Ala 130 135 140 atc atc agc ccc agc atc ttc tcc ttg gca aag ctc aaa cat cct tct 480 Ile Ile Ser Pro Ser Ile Phe Ser Leu Ala Lys Leu Lys His Pro Ser 145 150 155 160 gca agt cac atc tta gga ttc ttc ctt ttc tca tgg gtc ctc aac atg 528 Ala Ser His Ile Leu Gly Phe Phe Leu Phe Ser Trp Val Leu Asn Met 165 170 175 ttc att ggt gta atc ttc tgc tgt aca ctg cgg cta ccc cca gtg aaa 576 Phe Ile Gly Val Ile Phe Cys Cys Thr Leu Arg Leu Pro Pro Val Lys 180 185 190 cgg ggc cag tct tct gtt tgt cat aca gca ctg ttc ctt ttt gcc cat 624 Arg Gly Gln Ser Ser Val Cys His Thr Ala Leu Phe Leu Phe Ala His 195 200 205 gag cta cac cca cag gag act gtt ttt cac act aat gac ttt gag gga 672 Glu Leu His Pro Gln Glu Thr Val Phe His Thr Asn Asp Phe Glu Gly 210 215 220 tgt cac ctt tat agg gtt cat ggt cct ctc aag agg cta cat ggt gat 720 Cys His Leu Tyr Arg Val His Gly Pro Leu Lys Arg Leu His Gly Asp 225 230 235 240 tat ttt ata cag aca ata aga ggc tat ctc agt gcc ttc aca cag cca 768 Tyr Phe Ile Gln Thr Ile Arg Gly Tyr Leu Ser Ala Phe Thr Gln Pro 245 250 255 gcc tgt ccc cga gtc tca cca gtg aaa aga gcc tcc cag gct atc tta 816 Ala Cys Pro Arg Val Ser Pro Val Lys Arg Ala Ser Gln Ala Ile Leu 260 265 270 ctg ctg gtg agt ttt gtc ttc aca tac tgg gtg gac ttt acg ttc tca 864 Leu Leu Val Ser Phe Val Phe Thr Tyr Trp Val Asp Phe Thr Phe Ser 275 280 285 ttt tca gga ggt gtg aca tgg ata aat gat tct ctg cta gtg tgg ctc 912 Phe Ser Gly Gly Val Thr Trp Ile Asn Asp Ser Leu Leu Val Trp Leu 290 295 300 cag gtt att gtg gcc aat agc tat gcc gca att agt cct ttg atg cta 960 Gln Val Ile Val Ala Asn Ser Tyr Ala Ala Ile Ser Pro Leu Met Leu 305 310 315 320 att tat gct gat aac caa ata ttc aag act ctg caa atg tta tgg ttt 1008 Ile Tyr Ala Asp Asn Gln Ile Phe Lys Thr Leu Gln Met Leu Trp Phe 325 330 335 aaa tat ttg tct cct cca aag ctc atg ttg aaa ttt aat cgc caa tgt 1056 Lys Tyr Leu Ser Pro Pro Lys Leu Met Leu Lys Phe Asn Arg Gln Cys 340 345 350 ggc agt act aag aag tga 1074 Gly Ser Thr Lys Lys 355 <210> 70 <211> 357 <212> PRT <213> Homo sapiens <400> 70 Met Leu Lys Leu Val Ile Ile Glu Asn Met Ala Glu Ile Met Leu Phe 1 5 10 15 Ser Leu Asp Leu Leu Leu Phe Ser Thr Asp Ile Leu Cys Phe Asn Phe 20 25 30 Pro Ser Lys Met Ile Lys Leu Pro Gly Phe Ile Thr Ile Gln Ile Phe 35 40 45 Phe Tyr Pro Gln Ala Ser Phe Gly Ile Ser Ala Asn Thr Ile Leu Leu 50 55 60 Leu Tyr His Ile Phe Thr Phe Val Phe Ser His Arg Ser Lys Ser Ile 65 70 75 80 Asp Met Ile Ile Ser His Leu Ser Leu Ile His Ile Leu Leu Leu Phe 85 90 95 Thr Gln Ala Ile Leu Val Ser Leu Asp Phe Phe Gly Ser Gln Asn Thr 100 105 110 Gln Asp Asp Leu Arg Tyr Lys Val Ile Val Phe Leu Asn Lys Val Met 115 120 125 Arg Gly Leu Ser Ile Cys Thr Pro Cys Leu Leu Ser Val Leu Gln Ala 130 135 140 Ile Ile Ser Pro Ser Ile Phe Ser Leu Ala Lys Leu Lys His Pro Ser 145 150 155 160 Ala Ser His Ile Leu Gly Phe Phe Leu Phe Ser Trp Val Leu Asn Met 165 170 175 Phe Ile Gly Val Ile Phe Cys Cys Thr Leu Arg Leu Pro Pro Val Lys 180 185 190 Arg Gly Gln Ser Ser Val Cys His Thr Ala Leu Phe Leu Phe Ala His 195 200 205 Glu Leu His Pro Gln Glu Thr Val Phe His Thr Asn Asp Phe Glu Gly 210 215 220 Cys His Leu Tyr Arg Val His Gly Pro Leu Lys Arg Leu His Gly Asp 225 230 235 240 Tyr Phe Ile Gln Thr Ile Arg Gly Tyr Leu Ser Ala Phe Thr Gln Pro 245 250 255 Ala Cys Pro Arg Val Ser Pro Val Lys Arg Ala Ser Gln Ala Ile Leu 260 265 270 Leu Leu Val Ser Phe Val Phe Thr Tyr Trp Val Asp Phe Thr Phe Ser 275 280 285 Phe Ser Gly Gly Val Thr Trp Ile Asn Asp Ser Leu Leu Val Trp Leu 290 295 300 Gln Val Ile Val Ala Asn Ser Tyr Ala Ala Ile Ser Pro Leu Met Leu 305 310 315 320 Ile Tyr Ala Asp Asn Gln Ile Phe Lys Thr Leu Gln Met Leu Trp Phe 325 330 335 Lys Tyr Leu Ser Pro Pro Lys Leu Met Leu Lys Phe Asn Arg Gln Cys 340 345 350 Gl y Ser Thr Lys Lys 355 <210> 71 <211> 627 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(627) <400> 71 atg gaa atg acc aag ctt ttc agc tat att gtc att aaa aat gtt tat 48 Met Glu Met Thr Lys Leu Phe Ser Tyr Ile Val Ile Lys Asn Val Tyr 1 5 10 15 tac cct caa gtc agc ttt gga atc tca gca aac acc ttc ctc ctt ctt 96 Tyr Pro Gln Val Ser Phe Gly Ile Ser Ala Asn Thr Phe Leu Leu Leu 20 25 30 ttc cac atc ttc act ttt gct tat act cac agg ctt aag ccc att gac 144 Phe His Ile Phe Thr Phe Ala Tyr Thr His Arg Leu Lys Pro Ile Asp 35 40 45 atg acc att agt cac ttg ccc cta atc cac ata ctg cta ctc ttc act 192 Met Thr Ile Ser His Leu Pro Leu Ile His Ile Leu Leu Leu Phe Thr 50 55 60 cag gcg ata ctg gtg tcc tcc gac tta ttt gaa tca tgg aat att cag 240 Gln Ala Ile Leu Val Ser Ser Asp Leu Phe Glu Ser Trp Asn Ile Gln 65 70 75 80 aac aat gat cta aag tgt aag atc atc aca ttt tta aac agg gtg atg 288 Asn Asn Asp Leu Lys Cys Lys Ile Ile Thr Phe Leu Asn Arg Val Met 85 90 95 agg gga gtc tcc atc tgc acc act tgc ctc cta agc gtg ctc cag gcc 336 Arg Gly Val Ser Ile Cys Thr Thr Cys Leu Leu Ser Val Leu Gln Ala 100 105 110 atc acc atc agc ccc agc acc tcc ttc ttg gaa aag ttt aaa cat att 384 Ile Thr Ile Ser Pro Ser Thr Ser Phe Leu Glu Lys Phe Lys His Ile 115 120 125 tct gca aat cac acc tta ggc ttc atc ctc ttc tca tgg gtc ctc aac 432 Ser Ala Asn His Thr Leu Gly Phe Ile Leu Phe Ser Trp Val Leu Asn 130 135 140 atg ttc att act aat aac ctt ttg ctt ttc att gtg cct acc ccg aat 480 Met Phe Ile Thr Asn Asn Leu Leu Leu Phe Ile Val Pro Thr Pro Asn 145 150 155 160 agg att ggg gcc agt ctt ttg ttt gtc act gag cac tgt tat gtt ttg 528 Arg Ile Gly Ala Ser Leu Leu Phe Val Thr Glu His Cys Tyr Val Leu 165 170 175 ccc atg agc tac acc cac agg agc ctg ttt ttc ata cta atg gtt ttg 576 Pro Met Ser Tyr Thr His Arg Ser Leu Phe Phe Ile Leu Met Val Leu 180 185 190 agg gat gtc atc ttc ata gga ctc atg gtc ctc tca agt ggc tat ggg 624 Arg Asp Val Ile Phe Ile Gly Leu Met Val Leu Ser Ser Gly Tyr Gly 195 200 205 tga 627 <210> 72 <211> 208 <212> PRT <213> Homo sapiens <400> 72 Met Glu Met Thr Lys Leu Phe Ser Tyr Ile Val Ile Lys Asn Val Tyr 1 5 10 15 Tyr Pro Gln Val Ser Phe Gly Ile Ser Ala Asn Thr Phe Leu Leu Leu 20 25 30 Phe His Ile Phe Thr Phe Ala Tyr Thr His Arg Leu Lys Pro Ile Asp 35 40 45 Met Thr Ile Ser His Leu Pro Leu Ile His Ile Leu Leu Leu Phe Thr 50 55 60 Gln Ala Ile Leu Val Ser Ser Asp Leu Phe Glu Ser Trp Asn Ile Gln 65 70 75 80 Asn Asn Asp Leu Lys Cys Lys Ile Ile Thr Phe Leu Asn Arg Val Met 85 90 95 Arg Gly Val Ser Ile Cys Thr Thr Cys Leu Leu Ser Val Leu Gln Ala 100 105 110 Ile Thr Ile Ser Pro Ser Thr Ser Phe Leu Glu Lys Phe Lys His Ile 115 120 125 Ser Ala Asn His Thr Leu Gly Phe Ile Leu Phe Ser Trp Val Leu Asn 130 135 140 Met Phe Ile Thr Asn Asn Leu Leu Leu Phe Ile Val Pro Thr Pro Asn 145 150 155 160 Arg Ile Gly Ala Ser Leu Leu Phe Val Thr Glu His Cys Tyr Val Leu 165 170 175 Pro Met Ser Tyr Thr His Arg Ser Leu Phe Phe Ile Leu Met Val Leu 180 185 190 Arg Asp Val Ile Phe Ile Gly Leu Met Val Leu Ser Ser Gly Tyr Gly 195 200 205 <210> 73 <211> 993 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(993) <400> 73 atg acg ccc aac agc act ggc gag gtg ccc agc ccc att ccc aag ggg 48 Met Thr Pro Asn Ser Thr Gly Glu Val Pro Ser Pro Ile Pro Lys Gly 1 5 10 15 gct ttg ggg ctc tcc ctg gcc ctg gca agc ctc atc atc acc gcg aac 96 Ala Leu Gly Leu Ser Leu Ala Leu Ala Ser Leu Ile Ile Thr Ala Asn 20 25 30 ctg ctc cta gcc ctg ggc atc gcc tgg gac cgc cgc ctg cgc agc cca 144 Leu Leu Leu Ala Leu Gly Ile Ala Trp Asp Arg Arg Leu Arg Ser Pro 35 40 45 cct gct ggc tgc ttc ttc ctg agc cta ctg ctg gct ggg ctg ctc acg 192 Pro Ala Gly Cys Phe Phe Leu Ser Leu Leu Leu Ala Gly Leu Leu Thr 50 55 60 ggt ctg gca ttg ccc aca ttg cca ggg ctg tgg aac cag agt cgc cgg 240 Gly Leu Ala Leu Pro Thr Leu Pro Gly Leu Trp Asn Gln Ser Arg Arg 65 70 75 80 ggt tac tgg tcc tgc ctc ctc gtc tac ttg gct ccc aac ttc tcc ttc 288 Gly Tyr Trp Ser Cys Leu Leu Val Tyr Leu Ala Pro Asn Phe Ser Phe 85 90 95 ctc tcc ctg ctt gcc aac ctc ttg ctg gtg cac ggg gag cgc tac atg 336 Leu Ser Leu Leu Ala Asn Leu Leu Leu Val His Gly Glu Arg Tyr Met 100 105 110 gca gtc ctg agg cca ctc cag ccc cct ggg agc att cgg ctg gcc ctg 384 Ala Val Leu Arg Pro Leu Gln Pro Pro Gly Ser Ile Arg Leu Ala Leu 115 120 125 ctc ctc acc tgg gct ggt ccc ctg ctc ttt gcc agt ctg ccc gct ctg 432 Leu Leu Thr Trp Ala Gly Pro Leu Leu Phe Ala Ser Leu Pro Ala Leu 130 135 140 ggg tgg aac cac tgg acc cct ggt gcc aac tgc agc tcc cag gct atc 480 Gly Trp Asn His Trp Thr Pro Gly Ala Asn Cys Ser Ser Gln Ala Ile 145 150 155 160 ttc cca gcc ccc tac ctg tac ctc gaa gtc tat ggg ctc ctg ctg ccc 528 Phe Pro Ala Pro Tyr Leu Tyr Leu Glu Val Tyr Gly Leu Leu Leu Pro 165 170 175 gcc gtg ggt gct gct gcc ttc ctc tct gtc cgc gtg ctg gcc act gcc 576 Ala Val Gly Ala Ala Ala Phe Leu Ser Val Arg Val Leu Ala Thr Ala 180 185 190 cac cgc cag ctg cag gac atc tgc cgg ctg gag cgg gca gtg tgc cgc 624 His Arg Gln Leu Gln Asp Ile Cys Arg Leu Glu Arg Ala Val Cys Arg 195 200 205 gat gag ccc tcc gcc ctg gcc cgg gcc ctt acc tgg agg cag gca agg 672 Asp Glu Pro Ser Ala Leu Ala Arg Ala Leu Thr Trp Arg Gln Ala Arg 210 215 220 gca cag gct gga gcc atg ctg ctc ttc ggg ctg tgc tgg ggg ccc tac 720 Ala Gln Ala Gly Ala Met Leu Leu Phe Gly Leu Cys Trp Gly Pro Tyr 225 230 235 240 gtg gcc aca ctg ctc ctc tca gtc ctg gcc tat gag cag cgc ccg cca 768 Val Ala Thr Leu Leu Leu Ser Val Leu Ala Tyr Glu Gln Arg Pro Pro 245 250 255 ctg ggg cct ggg aca ctg ttg tcc ctc ctc tcc cta gga agt gcc agt 816 Leu Gly Pro Gly Thr Leu Leu Ser Leu Leu Ser Leu Gly Ser Ala Ser 260 265 270 gca gcg gca gtg ccc gta gcc atg ggg ctg ggc gat cag cgc tac aca 864 Ala Ala Ala Val Pro Val Ala Met Gly Leu Gly Asp Gln Arg Tyr Thr 275 280 285 gcc ccc tgg agg gca gcc gcc caa agg tgc ctg cag ggg ctg tgg gga 912 Ala Pro Trp Arg Ala Ala Ala Gln Arg Cys Leu Gln Gly Leu Trp Gly 290 295 300 aga gcc tcc cgg gac agt ccc ggc ccc agc att gcc tac cac cca agc 960 Arg Ala Ser Arg Asp Ser Pro Gly Pro Ser Ile Ala Tyr His Pro Ser 305 310 315 320 agc caa agc agt gtc gac ctg gac ttg aac taa 993 Ser Gln Ser Ser Val Asp Leu Asp Leu Asn 325 330 <210> 74 <211> 330 <212> PRT <213> Homo sapiens <400> 74 Met Thr Pro Asn Ser Thr Gly Glu Val Pro Ser Pro Ile Pro Lys Gly 1 5 10 15 Ala Leu Gly Leu Ser Leu Ala Leu Ala Ser Leu Ile Ile Thr Ala Asn 20 25 30 Leu Leu Leu Ala Leu Gly Ile Ala Trp Asp Arg Arg Leu Arg Ser Pro 35 40 45 Pro Ala Gly Cys Phe Phe Leu Ser Leu Leu Leu Ala Gly Leu Leu Thr 50 55 60 Gly Leu Ala Leu Pro Thr Leu Pro Gly Leu Trp Asn Gln Ser Arg Arg 65 70 75 80 Gly Tyr Trp Ser Cys Leu Leu Val Tyr Leu Ala Pro Asn Phe Ser Phe 85 90 95 Leu Ser Leu Leu Ala Asn Leu Leu Leu Val His Gly Glu Arg Tyr Met 100 105 110 Ala Val Leu Arg Pro Leu Gln Pro Pro Gly Ser Ile Arg Leu Ala Leu 115 120 125 Leu Leu Thr Trp Ala Gly Pro Leu Leu Phe Ala Ser Leu Pro Ala Leu 130 135 140 Gly Trp Asn His Trp Thr Pro Gly Ala Asn Cys Ser Ser Gln Ala Ile 145 150 155 160 Phe Pro Ala Pro Tyr Leu Tyr Leu Glu Val Tyr Gly Leu Leu Leu Pro 165 170 175 Ala Val Gly Ala Ala Ala Phe Leu Ser Val Arg Val Leu Ala Thr Ala 180 185 190 His Arg Gln Leu Gln Asp Ile Cys Arg Leu Glu Arg Ala Val Cys Arg 195 200 205 Asp Glu Pro Ser Ala Leu Ala Arg Ala Leu Thr Trp Arg Gln Ala Arg 210 215 220 Ala Gln Ala Gly Ala Met Leu Leu Phe Gly Leu Cys Trp Gly Pro Tyr 225 230 235 240 Val Ala Thr Leu Leu Leu Ser Val Leu Ala Tyr Glu Gln Arg Pro Pro 245 250 255 Leu Gly Pro Gly Thr Leu Leu Ser Leu Leu Ser Leu Gly Ser Ala Ser 260 265 270 Ala Ala Ala Val Pro Val Ala Met Gly Leu Gly Asp Gln Arg Tyr Thr 275 280 285 Ala Pro Trp Arg Ala Ala Ala Gln Arg Cys Leu Gln Gly Leu Trp Gly 290 295 300 Arg Ala Ser Arg Asp Ser Pro Gly Pro Ser Ile Ala Tyr His Pro Ser 305 310 315 320 Ser Gln Ser Ser Val Asp Leu Asp Leu Asn 325 330 <210> 75 <211> 1002 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1002) <400> 75 atg cct gct aat tac acg tgt acc agg cca gat gga gac aat aca gat 48 Met Pro Ala Asn Tyr Thr Cys Thr Arg Pro Asp Gly Asp Asn Thr Asp 1 5 10 15 ttt cga tac ttt att tat gca gtg aca tac act gtc att ctt gtg cca 96 Phe Arg Tyr Phe Ile Tyr Ala Val Thr Tyr Thr Val Ile Leu Val Pro 20 25 30 ggt ctc ata ggg aat ata tta gcc ctg tgg gta ttc tat ggt tat atg 144 Gly Leu Ile Gly Asn Ile Leu Ala Leu Trp Val Phe Tyr Gly Tyr Met 35 40 45 aaa gaa aca aaa cga gct gtg ata ttt atg ata aac tta gcc att gct 192 Lys Glu Thr Lys Arg Ala Val Ile Phe Met Ile Asn Leu Ala Ile Ala 50 55 60 gac tta cta caa gtt ctt tcc ttg cca ctg agg atc ttc tac tac ttg 240 Asp Leu Leu Gln Val Leu Ser Leu Pro Leu Arg Ile Phe Tyr Tyr Leu 65 70 75 80 aat cat gac tgg cca ttt ggg cct ggt ctc tgc atg ttc tgt ttc tac 288 Asn His Asp Trp Pro Phe Gly Pro Gly Leu Cys Met Phe Cys Phe Tyr 85 90 95 ctg aag tat gtc aac atg tat gca agc atc tac ttc ttg gtc tgc atc 336 Leu Lys Tyr Val Asn Met Tyr Ala Ser Ile Tyr Phe Leu Val Cys Ile 100 105 110 agt gtg cga cga ttt tgg ttt ctc atg tac ccc ttt cgc ttc cat gac 384 Ser Val Arg Arg Phe Trp Phe Leu Met Tyr Pro Phe Arg Phe His Asp 115 120 125 tgc aaa cag aaa tat gac ctg tac atc agc att gct ggc tgg ctg atc 432 Cys Lys Gln Lys Tyr Asp Leu Tyr Ile Ser Ile Ala Gly Trp Leu Ile 130 135 140 atc tgc ctt gcc tgt gta ctc ttt cca ctc ctc aga acc agt gat gat 480 Ile Cys Leu Ala Cys Val Leu Phe Pro Leu Leu Arg Thr Ser Asp Asp 145 150 155 160 acc tct ggc aat agg acc aaa tgc ttt gtg gat ctt cct acc agg aat 528 Thr Ser Gly Asn Arg Thr Lys Cys Phe Val Asp Leu Pro Thr Arg Asn 165 170 175 gtc aac ctg gcc cag tcc gtt gtt atg atg acc att ggc gag ttg att 576 Val Asn Leu Ala Gln Ser Val Val Met Met Thr Ile Gly Glu Leu Ile 180 185 190 ggg ttt gta act ccg ctt ctg att gtc cta tat tgt acc tgg aag acg 624 Gly Phe Val Thr Pro Leu Leu Ile Val Leu Tyr Cys Thr Trp Lys Thr 195 200 205 gtt tta tca ctg caa gat aaa tat ccc atg gcc caa gat ctt gga gag 672 Val Leu Ser Leu Gln Asp Lys Tyr Pro Met Ala Gln Asp Leu Gly Glu 210 215 220 aaa cag aaa gcc ttg aag atg att cta acc tgt gca ggg gta ttc cta 720 Lys Gln Lys Ala Leu Lys Met Ile Leu Thr Cys Ala Gly Val Phe Leu 225 230 235 240 att tgc ttt gca cct tat cat ttc agt ttt cct tta gat ttc ctg gtg 768 Ile Cys Phe Ala Pro Tyr His Phe Ser Phe Pro Leu Asp Phe Leu Val 245 250 255 aag tcc aat gaa att aaa agc tgc cta gcc aga agg gtg att cta ata 816 Lys Ser Asn Glu Ile Lys Ser Cys Leu Ala Arg Arg Val Ile Leu Ile 260 265 270 ttt cat tct gtg gca ttg tgt ctt gct agt ctg aat tca tgt ctt gac 864 Phe His Ser Val Ala Leu Cys Leu Ala Ser Leu Asn Ser Cys Leu Asp 275 280 285 cca gtc ata tac tac ttt tcc act aat gag ttc cga aga cgg ctt tca 912 Pro Val Ile Tyr Tyr Phe Ser Thr Asn Glu Phe Arg Arg Arg Leu Ser 290 295 300 aga caa gat ttg cat gac agc atc caa ctc cat gca aaa tcc ttt gtg 960 Arg Gln Asp Leu His Asp Ser Ile Gln Leu His Ala Lys Ser Phe Val 305 310 315 320 agt aac cat aca gct tcc acc atg aca cct gaa tta tgc taa 1002 Ser Asn His Thr Ala Ser Thr Met Thr Pro Glu Leu Cys 325 330 <210> 76 <211> 333 <212> PRT <213> Homo sapiens <400> 76 Met Pro Ala Asn Tyr Thr Cys Thr Arg Pro Asp Gly Asp Asn Thr Asp 1 5 10 15 Phe Arg Tyr Phe Ile Tyr Ala Val Thr Tyr Thr Val Ile Leu Val Pro 20 25 30 Gly Leu Ile Gly Asn Ile Leu Ala Leu Trp Val Phe Tyr Gly Tyr Met 35 40 45 Lys Glu Thr Lys Arg Ala Val Ile Phe Met Ile Asn Leu Ala Ile Ala 50 55 60 Asp Leu Leu Gln Val Leu Ser Leu Pro Leu Arg Ile Phe Tyr Tyr Leu 65 70 75 80 Asn His Asp Trp Pro Phe Gly Pro Gly Leu Cys Met Phe Cys Phe Tyr 85 90 95 Leu Lys Tyr Val Asn Met Tyr Ala Ser Ile Tyr Phe Leu Val Cys Ile 100 105 110 Ser Val Arg Arg Phe Trp Phe Leu Met Tyr Pro Phe Arg Phe His Asp 115 120 125 Cys Lys Gln Lys Tyr Asp Leu Tyr Ile Ser Ile Ala Gly Trp Leu Ile 130 135 140 Ile Cys Leu Ala Cys Val Leu Phe Pro Leu Leu Arg Thr Ser Asp Asp 145 150 155 160 Thr Ser Gly Asn Arg Thr Lys Cys Phe Val Asp Leu Pro Thr Arg Asn 165 170 175 Val Asn Leu Ala Gln Ser Val Val Met Met Thr Ile Gly Glu Leu Ile 180 185 190 Gly Phe Val Thr Pro Leu Leu Ile Val Leu Tyr Cys Thr Trp Lys Thr 195 200 205 Val Leu Ser Leu Gln Asp Lys Tyr Pro Met Ala Gln Asp Leu Gly Glu 210 215 220 Lys Gln Lys Ala Leu Lys Met Ile Leu Thr Cys Ala Gly Val Phe Leu 225 230 235 240 Ile Cys Phe Ala Pro Tyr His Phe Ser Phe Pro Leu Asp Phe Leu Val 245 250 255 Lys Ser Asn Glu Ile Lys Ser Cys Leu Ala Arg Arg Val Ile Leu Ile 260 265 270 Phe His Ser Val Ala Leu Cys Leu Ala Ser Leu Asn Ser Cys Leu Asp 275 280 285 Pro Val Ile Tyr Tyr Phe Ser Thr Asn Glu Phe Arg Arg Arg Leu Ser 290 295 300 Arg Gln Asp Leu His Asp Ser Ile Gln Leu His Ala Lys Ser Phe Val 305 310 315 320 Ser Asn His Thr Ala Ser Thr Met Thr Pro Glu Leu Cys 325 330 <210> 77 <211> 1002 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1002) <400> 77 atg aac acc aca gtg atg caa ggc ttc aac aga tct gag cgg tgc ccc 48 Met Asn Thr Thr Val Met Gln Gly Phe Asn Arg Ser Glu Arg Cys Pro 1 5 10 15 aga gac act cgg ata gta cag ctg gta ttc cca gcc ctc tac aca gtg 96 Arg Asp Thr Arg Ile Val Gln Leu Val Phe Pro Ala Leu Tyr Thr Val 20 25 30 gtt ttc ttg acc ggc atc ctg ctg aat act ttg gct ctg tgg gtg ttt 144 Val Phe Leu Thr Gly Ile Leu Leu Asn Thr Leu Ala Leu Trp Val Phe 35 40 45 gtt cac atc ccc agc tcc tcc acc ttc atc atc tac ctc aaa aac act 192 Val His Ile Pro Ser Ser Ser Thr Phe Ile Ile Tyr Leu Lys Asn Thr 50 55 60 ttg gtg gcc gac ttg ata atg aca ctc atg ctt cct ttc aaa atc ctc 240 Leu Val Ala Asp Leu Ile Met Thr Leu Met Leu Pro Phe Lys Ile Leu 65 70 75 80 tct gac tca cac ctg gca ccc tgg cag ctc aga gct ttt gtg tgt cgt 288 Ser Asp Ser His Leu Ala Pro Trp Gln Leu Arg Ala Phe Val Cys Arg 85 90 95 ttt tct tcg gtg ata ttt tat gag acc atg tat gtg ggc atc gtg ctg 336 Phe Ser Ser Val Ile Phe Tyr Glu Thr Met Tyr Val Gly Ile Val Leu 100 105 110 tta ggg ctc ata gcc ttt gac aga ttc ctc aag atc atc aga cct ttg 384 Leu Gly Leu Ile Ala Phe Asp Arg Phe Leu Lys Ile Ile Arg Pro Leu 115 120 125 aga aat att ttt cta aaa aaa cct gtt ttt gca aaa acg gtc tca atc 432 Arg Asn Ile Phe Leu Lys Lys Pro Val Phe Ala Lys Thr Val Ser Ile 130 135 140 ttc atc tgg ttc ttt ttg ttc ttc atc tcc ctg cca aat acg atc ttg 480 Phe Ile Trp Phe Phe Leu Phe Phe Ile Ser Leu Pro Asn Thr Ile Leu 145 150 155 160 agc aac aag gaa gca aca cca tcg tct gtg aaa aag tgt gct tcc tta 528 Ser Asn Lys Glu Ala Thr Pro Ser Ser Val Lys Lys Cys Ala Ser Leu 165 170 175 aag ggg cct ctg ggg ctg aaa tgg cat caa atg gta aat aac ata tgc 576 Lys Gly Pro Leu Gly Leu Lys Trp His Gln Met Val Asn Asn Ile Cys 180 185 190 cag ttt att ttc tgg act gtt ttt atc cta atg ctt gtg ttt tat gtg 624 Gln Phe Ile Phe Trp Thr Val Phe Ile Leu Met Leu Val Phe Tyr Val 195 200 205 gtt att gca aaa aaa gta tat gat tct tat aga aag tcc aaa agt aag 672 Val Ile Ala Lys Lys Val Tyr Asp Ser Tyr Arg Lys Ser Lys Ser Lys 210 215 220 gac aga aaa aac aac aaa aag ctg gaa ggc aaa gta ttt gtt gtc gtg 720 Asp Arg Lys Asn Asn Lys Lys Leu Glu Gly Lys Val Phe Val Val Val 225 230 235 240 gct gtc ttc ttt gtg tgt ttt gct cca ttt cat ttt gcc aga gtt cca 768 Ala Val Phe Phe Val Cys Phe Ala Pro Phe His Phe Ala Arg Val Pro 245 250 255 tat act cac agt caa acc aac aat aag act gac tgt aga ctg caa aat 816 Tyr Thr His Ser Gln Thr Asn Asn Lys Thr Asp Cys Arg Leu Gln Asn 260 265 270 caa ctg ttt att gct aaa gaa aca act ctc ttt ttg gca gca act aac 864 Gln Leu Phe Ile Ala Lys Glu Thr Thr Leu Phe Leu Ala Ala Thr Asn 275 280 285 att tgt atg gat ccc tta ata tac ata ttc tta tgt aaa aaa ttc aca 912 Ile Cys Met Asp Pro Leu Ile Tyr Ile Phe Leu Cys Lys Lys Phe Thr 290 295 300 gaa aag cta cca tgt atg caa ggg aga aag acc aca gca tca agc caa 960 Glu Lys Leu Pro Cys Met Gln Gly Arg Lys Thr Thr Ala Ser Ser Gln 305 310 315 320 gaa aat cat agc agt cag aca gac aac ata acc tta ggc tga 1002 Glu Asn His Ser Ser Gln Thr Asp Asn Ile Thr Leu Gly 325 330 <210> 78 <211> 333 <212> PRT <213> Homo sapiens <400> 78 Met Asn Thr Thr Val Met Gln Gly Phe Asn Arg Ser Glu Arg Cys Pro 1 5 10 15 Arg Asp Thr Arg Ile Val Gln Leu Val Phe Pro Ala Leu Tyr Thr Val 20 25 30 Val Phe Leu Thr Gly Ile Leu Leu Asn Thr Leu Ala Leu Trp Val Phe 35 40 45 Val His Ile Pro Ser Ser Ser Thr Phe Ile Ile Tyr Leu Lys Asn Thr 50 55 60 Leu Val Ala Asp Leu Ile Met Thr Leu Met Leu Pro Phe Lys Ile Leu 65 70 75 80 Ser Asp Ser His Leu Ala Pro Trp Gln Leu Arg Ala Phe Val Cys Arg 85 90 95 Phe Ser Ser Val Ile Phe Tyr Glu Thr Met Tyr Val Gly Ile Val Leu 100 105 110 Leu Gly Leu Ile Ala Phe Asp Arg Phe Leu Lys Ile Ile Arg Pro Leu 115 120 125 Arg Asn Ile Phe Leu Lys Lys Pro Val Phe Ala Lys Thr Val Ser Ile 130 135 140 Phe Ile Trp Phe Phe Leu Phe Phe Ile Ser Leu Pro Asn Thr Ile Leu 145 150 155 160 Ser Asn Lys Glu Ala Thr Pro Ser Ser Val Lys Lys Cys Ala Ser Leu 165 170 175 Lys Gly Pro Leu Gly Leu Lys Trp His Gln Met Val Asn Asn Ile Cys 180 185 190 Gln Phe Ile Phe Trp Thr Val Phe Ile Leu Met Leu Val Phe Tyr Val 195 200 205 Val Ile Ala Lys Lys Val Tyr Asp Ser Tyr Arg Lys Ser Lys Ser Lys 210 215 220 Asp Arg Lys Asn Asn Lys Lys Leu Glu Gly Lys Val Phe Val Val Val 225 230 235 240 Ala Val Phe Phe Val Cys Phe Ala Pro Phe His Phe Ala Arg Val Pro 245 250 255 Tyr Thr His Ser Gln Thr Asn Asn Lys Thr Asp Cys Arg Leu Gln Asn 260 265 270 Gln Leu Phe Ile Ala Lys Glu Thr Thr Leu Phe Leu Ala Ala Thr Asn 275 280 285 Ile Cys Met Asp Pro Leu Ile Tyr Ile Phe Leu Cys Lys Lys Phe Thr 290 295 300 Glu Lys Leu Pro Cys Met Gln Gly Arg Lys Thr Thr Ala Ser Ser Gln 305 310 315 320 Glu Asn His Ser Ser Gln Thr Asp Asn Ile Thr Leu Gly 325 330 <210> 79 <211> 1539 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1539) <400> 79 atg tgg ttc gtg act gag cca att ctc tgg gca ttt ttc cta ttc tta 48 Met Trp Phe Val Thr Glu Pro Ile Leu Trp Ala Phe Phe Leu Phe Leu 1 5 10 15 atg cta atg act atc cac tgc tgg tcc tct tat ctg ttt act caa aaa 96 Met Leu Met Thr Ile His Cys Trp Ser Ser Tyr Leu Phe Thr Gln Lys 20 25 30 cac aaa ctg act ctc atc ctt gtg ttt cag gat gtc atc agt ata gct 144 His Lys Leu Thr Leu Ile Leu Val Phe Gln Asp Val Ile Ser Ile Ala 35 40 45 gac aat atc ctt aat tca gcc tca gta acc aac tgg aca gtc tta ctg 192 Asp Asn Ile Leu Asn Ser Ala Ser Val Thr Asn Trp Thr Val Leu Leu 50 55 60 cgg gaa gaa aag tat gcc agc tca cgg tta cta gag aca tta gaa aac 240 Arg Glu Glu Lys Tyr Ala Ser Ser Arg Leu Leu Glu Thr Leu Glu Asn 65 70 75 80 atc agc act ctg gtg cct ccg aca gct ctt cct ctg aat ttt tct cgg 288 Ile Ser Thr Leu Val Pro Pro Thr Ala Leu Pro Leu Asn Phe Ser Arg 85 90 95 aaa ttc att gac tgg aaa ggg att cca gtg aac aaa agc caa ctc aaa 336 Lys Phe Ile Asp Trp Lys Gly Ile Pro Val Asn Lys Ser Gln Leu Lys 100 105 110 agg ggt tac agc tat cag att aaa atg tgt ccc caa aat aca tct att 384 Arg Gly Tyr Ser Tyr Gln Ile Lys Met Cys Pro Gln Asn Thr Ser Ile 115 120 125 ccc atc aga ggc cgt gtg tta att ggg tca gac caa ttc cag aga tcc 432 Pro Ile Arg Gly Arg Val Leu Ile Gly Ser Asp Gln Phe Gln Arg Ser 130 135 140 ctt cca gaa act att atc agc atg gcc tcg ttg act ctg ggg aac att 480 Leu Pro Glu Thr Ile Ile Ser Met Ala Ser Leu Thr Leu Gly Asn Ile 145 150 155 160 cta ccc gtt tcc aaa aat gga aat gct cag gtc aat gga cct gtg ata 528 Leu Pro Val Ser Lys Asn Gly Asn Ala Gln Val Asn Gly Pro Val Ile 165 170 175 tcc acg gtt att caa aac tat tcc ata aat gaa gtt ttc cta ttt ttt 576 Ser Thr Val Ile Gln Asn Tyr Ser Ile Asn Glu Val Phe Leu Phe Phe 180 185 190 tcc aag ata gag tca aac ctg agc cag cct cat tgt gtg ttt tgg gat 624 Ser Lys Ile Glu Ser Asn Leu Ser Gln Pro His Cys Val Phe Trp Asp 195 200 205 ttc agt cat ttg cag tgg aac gat gca ggc tgc cac cta gtg aat gaa 672 Phe Ser His Leu Gln Trp Asn Asp Ala Gly Cys His Leu Val Asn Glu 210 215 220 act caa gac atc gtg acg tgc caa tgt act cac ttg acc tcc ttc tcc 720 Thr Gln Asp Ile Val Thr Cys Gln Cys Thr His Leu Thr Ser Phe Ser 225 230 235 240 atg ttg atg tca cct ttt gtc ccc tct aca atc ttc ccc gtt gta aaa 768 Met Leu Met Ser Pro Phe Val Pro Ser Thr Ile Phe Pro Val Val Lys 245 250 255 tgg atc acc tat gtg gga ctg ggt atc tcc att gga agt ctc att tta 816 Trp Ile Thr Tyr Val Gly Leu Gly Ile Ser Ile Gly Ser Leu Ile Leu 260 265 270 tgc ctg atc atc gag gct ttg ttt tgg aag cag att aaa aaa agc caa 864 Cys Leu Ile Ile Glu Ala Leu Phe Trp Lys Gln Ile Lys Lys Ser Gln 275 280 285 acc tct cac aca cgt cgt att tgc atg gtg aac ata gcc ctg tcc ctc 912 Thr Ser His Thr Arg Arg Ile Cys Met Val Asn Ile Ala Leu Ser Leu 290 295 300 ttg att gct gat gtc tgg ttt att gtt ggt gcc aca gtg gac acc acg 960 Leu Ile Ala Asp Val Trp Phe Ile Val Gly Ala Thr Val Asp Thr Thr 305 310 315 320 gtg aac cct tct gga gtc tgc aca gct gct gtg ttc ttt aca cac ttc 1008 Val Asn Pro Ser Gly Val Cys Thr Ala Ala Val Phe Phe Thr His Phe 325 330 335 ttc tac ctc tct ttg ttc ttc tgg atg ctc atg ctt ggc atc ctg ctg 1056 Phe Tyr Leu Ser Leu Phe Phe Trp Met Leu Met Leu Gly Ile Leu Leu 340 345 350 gc t tac cgg atc atc ctc gtg ttc cat cac atg gcc cag cat ttg atg 1104 Ala Tyr Arg Ile Ile Leu Val Phe His His Met Ala Gln His Leu Met 355 360 365 atg gct gtt gga ttt tgc ctg ggt tat ggg tgc cct ctc att ata tct 1152 Met Ala Val Gly Phe Cys Leu Gly Tyr Gly Cys Pro Leu Ile Ile Ser 370 375 380 gtc att acc att gct gtc acg caa cct agc aat acc tac aaa agg aaa 1200 Val Ile Thr Ile Ala Val Thr Gln Pro Ser Asn Thr Tyr Lys Arg Lys 385 390 395 400 gat gtg tgt tgg ctt aac tgg tcc aat gga agc aaa cca ctc ctg gct 1248 Asp Val Cys Trp Leu Asn Trp Ser Asn Gly Ser Lys Pro Leu Leu Ala 405 410 415 ttt gtt gtc cct gca ctg gct att gtg gct gtg aac ttc gtt gtg gtg 1296 Phe Val Val Pro Ala Leu Ala Ile Val Ala Val Asn Phe Val Val Val 420 425 430 ctg cta gtt ctc aca aag ctc tgg agg ccg act gtt ggg gaa aga ctg 1344 Leu Leu Val Leu Thr Lys Leu Trp Arg Pro Thr Val Gly Glu Arg Leu 435 440 445 agt cgg gat gac aag gcc acc atc gtc cgc gtg ggg aag agc ctc ctc 1392 Ser Arg Asp Asp Lys Ala Thr Ile Val Arg Val Gly Lys Ser Leu Leu 450 455 460 att ctg acc cct ctg cta ggg ctc acc tgg ggc ttt gga ata gga aca 1440 Ile Leu Thr Pro Leu Leu Gly Leu Thr Trp Gly Phe Gly Ile Gly Thr 465 470 475 480 ata gtg gac agc cag aat ctg gct tgg cat gtt att ttt gct tta ctc 1488 Ile Val Asp Ser Gln Asn Leu Ala Trp His Val Ile Phe Ala Leu Leu 485 490 495 aat gca ttc cag gtg aga aca gta aca ata acc tat tgt att gtc aag 1536 Asn Ala Phe Gln Val Arg Thr Val Thr Ile Thr Tyr Cys Ile Val Lys 500 505 510 tga 1539 <210> 80 <211> 512 <212> PRT <213> Homo sapiens <400> 80 Met Trp Phe Val Thr Glu Pro Ile Leu Trp Ala Phe Phe Leu Phe Leu 1 5 10 15 Met Leu Met Thr Ile His Cys Trp Ser Ser Tyr Leu Phe Thr Gln Lys 20 25 30 His Lys Leu Thr Leu Ile Leu Val Phe Gln Asp Val Ile Ser Ile Ala 35 40 45 A sp Asn Ile Leu Asn Ser Ala Ser Val Thr Asn Trp Thr Val Leu Leu 50 55 60 Arg Glu Glu Lys Tyr Ala Ser Ser Arg Leu Leu Glu Thr Leu Glu Asn 65 70 75 80 Ile Ser Thr Leu Val Pro Pro Thr Ala Leu Pro Leu Asn Phe Ser Arg 85 90 95 Lys Phe Ile Asp Trp Lys Gly Ile Pro Val Asn Lys Ser Gln Leu Lys 100 105 110 Arg Gly Tyr Ser Tyr Gln Ile Lys Met Cys Pro Gln Asn Thr Ser Ile 115 120 125 Pro Ile Arg Gly Arg Val Leu Ile Gly Ser Asp Gln Phe Gln Arg Ser 130 135 140 Leu Pro Glu Thr Ile Ile Ser Met Ala Ser Leu Thr Leu Gly Asn Ile 145 150 155 160 Leu Pro Val Ser Lys Asn Gly Asn Ala Gln Val Asn Gly Pro Val Ile 165 170 175 Ser Thr Val Ile Gln Asn Tyr Ser Ile Asn Glu Val Phe Leu Phe Phe 180 185 190 Ser Lys Ile Glu Ser Asn Leu Ser Gln Pro His Cys Val Phe Trp Asp 195 200 205 Phe Ser His Leu Gln Trp Asn Asp Ala Gly Cys His Leu Val Asn Glu 210 215 220 Thr Gln Asp Ile Val Thr Cys Gln Cys Thr His Leu Thr Ser Phe Ser 225 230 235 240 Met Leu Met Ser Pro Phe Val Pro Ser Thr Ile Phe Pro Val Val Lys 245 250 255 Trp Ile Thr Tyr Val Gly Leu Gly Ile Ser Ile Gly Ser Leu Ile Leu 260 265 270 Cys Leu Ile Ile Glu Ala Leu Phe Trp Lys Gln Ile Lys Lys Ser Gln 275 280 285 Thr Ser His Thr Arg Arg Ile Cys Met Val Asn Ile Ala Leu Ser Leu 290 295 300 Leu Ile Ala Asp Val Trp Phe Ile Val Gly Ala Thr Val Asp Thr Thr 305 310 315 320 Val Asn Pro Ser Gly Val Cys Thr Ala Ala Val Phe Phe Thr His Phe 325 330 335 Phe Tyr Leu Ser Leu Phe Phe Trp Met Leu Met Leu Gly Ile Leu Leu 340 345 350 Ala Tyr Arg Ile Ile Leu Val Phe His His Met Ala Gln His Leu Met 355 360 365 Met Ala Val Gly Phe Cys Leu Gly Tyr Gly Cys Pro Leu Ile Ile Ser 370 375 380 Val Ile Thr Ile Ala Val Thr Gln Pro Ser Asn Thr Tyr Lys Arg Lys 385 390 395 400 Asp Val Cys Trp Leu Asn Trp Ser Asn Gly Ser Lys Pro Leu Leu Ala 405 410 415 Phe Val Val Pro Ala Leu Ala Ile Val Ala Val Asn Phe Val Val Val 420 425 430 Leu Leu Val Leu Thr Lys Leu Trp Arg Pro Thr Val Gly Glu Arg Leu 435 440 445 Ser Arg Asp Asp Lys Ala Thr Ile Val Arg Val Gly Lys Ser Leu Leu 450 455 460 Ile Leu Thr Pro Leu Leu Gly Leu Thr Trp Gly Phe Gly Ile Gly Thr 465 470 475 480 Ile Val Asp Ser Gln Asn Leu Ala Trp His Val Ile Phe Ala Leu Leu 485 490 495 Asn Ala Phe Gln Val Arg Thr Val Thr Ile Thr Tyr Cys Ile Val Lys 500 505 510 <210> 81 < 211> 1143 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1143) <400> 81 atg ggc tcc tgg gct gct gtg aac ggg atc tgg gtg gag ctg cct gtg 48 Met Gly Ser Trp Ala Ala Val Asn Gly Ile Trp Val Glu Leu Pro Val 1 5 10 15 gtg gta aaa gac ctt cca gag ggt gag tgg gag gga ggt aca ggg aag 96 Val Val Lys Asp Leu Pro Glu Gly Glu Trp Glu Gly Gly Thr Gly Lys 20 25 30 cgt ggg gca ggt atg ccc aga aag gtg gcc tgt ggc agc tct ttg tcc 144 Arg Gly Ala Gly Met Pro Arg Lys Val Ala Cys Gly Ser Ser Leu Ser 35 40 45 ctt agc cac tgt gct cct gac atg gca tca ttc ctt ccc tgc agg ttg 192 Leu Ser His Cys Ala Pro Asp Met Ala Ser Phe Leu Pro Cys Arg Leu 50 55 60 gag ccn tcc cct cat acc tct ctg tgg ttg tgg cgc tgg gaa acc tgg 240 Glu Pro Ser Pro His Thr Ser Leu Trp Leu Trp Arg Trp Glu Thr Trp 65 70 75 80 ngt ctg ctg gtg gtg acc ctg tgg agg cag ctg gcc ccg ggc aag ggc 288 Xaa Leu Leu Val Val Thr Leu Trp Arg Gln Leu Ala Pro Gly Lys Gly 85 90 95 gag cag gtc ccc atc cag gtg gta cag gtg ctg agt gta gtg ggc aca 336 Glu Gln Val Pro Ile Gln Val Val Gln Val Leu Ser Val Val Gly Thr 100 105 110 gcc ctg ctg gcc cct ctg tgg cac cac gtg gcc cca gtg gca ggg cag 384 Ala Leu Leu Ala Pro Leu Trp His His Val Ala Pro Val Ala Gly Gln 115 120 125 ctc cac tct gtg gcc ttc cta act ctg gcc ttg gtg ttg gca atg gcc 432 Leu His Ser Val Ala Phe Leu Thr Leu Ala Leu Val Leu Ala Met Ala 130 135 140 tgt tgt acc tct aat gtc act ttc ctg ccc ttc ctg agc cac ctg cca 480 Cys Cys Thr Ser Asn Val Thr Phe Leu Pro Phe Leu Ser His Leu Pro 145 150 155 160 cct cct ttc tta cgg tct ttc ttc ctg ggt cag ggt ctc agt gcc cta 528 Pro Pro Phe Leu Arg Ser Phe Phe Leu Gly Gln Gly Leu Ser Ala Leu 165 170 175 ctc ccc tgt gtg ctg gcc cta gtg caa ggt gtg ggc cgc ctc gag tgc 576 Leu Pro Cys Val Leu Ala Leu Val Gln Gly Val Gly Arg Leu Glu Cys 180 185 190 cca cca gcg ccc acc aat ggc acc tct ggg cct ccc ctc gac ttc cct 624 Pro Pro Ala Pro Thr Asn Gly Thr Ser Gly Pro Pro Leu Asp Phe Pro 195 200 205 gag cgt ttt cct gcc agc acc ttc ttc tgg gca ctg act gcc ctt ctg 672 Glu Arg Phe Pro Ala Ser Thr Phe Phe Trp Ala Leu Thr Ala Leu Leu 210 215 220 gtc act tca gct gcc gcc ttc cgg ggt ctc ctg ttg ctg ttg cca tca 720 Val Thr Ser Ala Ala Ala Phe Arg Gly Leu Leu Leu Leu Leu Pro Ser 225 230 235 240 cta ccc tct gta acc aca ggg ggc tca ggg cct gaa ctt caa ctg gga 768 Leu Pro Ser Val Thr Thr Gly Gly Ser Gly Pro Glu Leu Gln Leu Gly 245 250 255 tcc cca gga gca gag gag gaa gag aag gag gaa gaa gag gct ttg cca 816 Ser Pro Gly Ala Glu Glu Glu Glu Lys Glu Glu Glu Glu Ala Leu Pro 260 265 270 ttg cag gag cca ccg agc cag gca gca ggc acc atc cct ggc cca gac 864 Leu Gln Glu Pro Pro Ser Gln Ala Ala Gly Thr Ile Pro Gly Pro Asp 275 280 285 cct gag gcc cat cag ctg ttc tca gcc cat ggt gcc ttc ctg ctg ggc 912 Pro Glu Ala His Gln Leu Phe Ser Ala His Gly Ala Phe Leu Leu Gly 290 295 300 ctg atg gcc ttc acc agt gcc gtg acc aat ggc gtg ctg cct tct gtg 960 Leu Met Ala Phe Thr Ser Ala Val Thr Asn Gly Val Leu Pro Ser Val 305 310 315 320 cag agc ttt tcc tgt ttg ccc tat ggg cgc ctg gcc tac cac ctg gct 1008 Gln Ser Phe Ser Cys Leu Pro Tyr Gly Arg Leu Ala Tyr His Leu Ala 325 330 335 gtg gtg ctg ggc agt gcc gcc aac ccc ctt gcc tgc ttc ctg gcc atg 1056 Val Val Leu Gly Ser Ala Ala Asn Pro Leu Ala Cys Phe Leu Ala Met 340 345 350 ggc gtg ctg tgc agg tgc aaa agg gtc ccc agg ctt ggt ggg tgg aac 1104 Gly Val Leu Cys Arg Cys Lys Arg Val Pro Arg Leu Gly Gly Trp Asn 355 360 365 tta agg ttg ggg tcc agg tcc cag aac agc cag ccc tga 1143 Leu Arg Leu Gly Ser Arg Ser Gln Asn Ser Gln Pro 370 375 380 <210> 82 <211> 380 <212> PRT <213> Homo sapiens <400> 82 Met Gly Ser Trp Ala Ala Val Asn Gly Ile Trp Val Glu Leu Pro Val 1 5 10 15 Val Val Lys Asp Leu Pro Glu Gly Glu Trp Glu Gly Gly Thr Gly Lys 20 25 30 Arg Gly Ala Gly Met Pro Arg Lys Val Ala Cys Gly Ser Ser Leu Ser 35 40 45 Leu Ser His Cys Ala Pro Asp Met Ala Ser Phe Leu Pro Cys Arg Leu 50 55 60 Glu Pro Ser Pro His Thr Ser Leu Trp Leu Trp Arg Trp Glu Thr Trp 65 70 75 80 Xaa Leu Leu Val Val Thr Leu Trp Arg Gln Leu Ala Pro Gly Lys Gly 85 90 95 Glu Gln Val Pro Ile Gln Val Val Gln Val Leu Ser Val Val Gly Thr 100 105 110 Ala Leu Leu Ala Pro Leu Trp His His Val Ala Pro Val Ala Gly Gln 115 120 125 Leu His Ser Val Ala Phe Leu Thr Leu Ala Leu Val Leu Ala Met Ala 130 135 140 Cys Cys Thr Ser Asn Val Thr Phe Leu Pro Phe Leu Ser His Leu Pro 145 150 155 160 Pro Pro Phe Leu Arg Ser Phe Phe Leu Gly Gln Gly Leu Ser Ala Leu 165 170 175 Leu Pro Cys Val Leu Ala Leu Val Gln Gly Val Gly Arg Leu Glu Cys 180 185 190 Pro Pro Ala Pro Thr Asn Gly Thr Ser Gly Pro Pro Leu Asp Phe Pro 195 200 205 Glu Arg Phe Pro Ala Ser Thr Phe Phe Trp Ala Leu Thr Ala Leu Leu 210 215 220 Val Thr Ser Ala Ala Ala Phe Arg Gly Leu Leu Leu Leu Leu Pro Ser 225 230 235 240 Leu Pro Ser Val Thr Thr Gly Gly Ser Gly Pro Glu Leu Gln Leu Gly 245 250 255 Ser Pro Gly Ala Glu Glu Glu Glu Lys Glu Glu Glu Glu Ala Leu Pro 260 265 270 Leu Gln Glu Pro Pro Ser Gln Ala Ala Gly Thr Ile Pro Gly Pro Asp 275 280 285 Pro Glu Ala His Gln Leu Phe Ser Ala His Gly Ala Phe Leu Leu Gly 290 295 300 Leu Met Ala Phe Thr Ser Ala Val Thr Asn Gly Val Leu Pro Ser Val 305 310 315 320 Gln Ser Phe Ser Cys Leu Pro Tyr Gly Arg Leu Ala Tyr His Leu Ala 325 330 335 Val Val Leu Gly Ser Ala Ala Asn Pro Leu Ala Cys Phe Leu Ala Met 340 345 350 Gly Val Leu Cys Arg Cys Lys Arg Val Pro Arg Leu Gly Gly Trp Asn 355 360 365 Leu Arg Leu Gly Ser Arg Ser Gln Asn Ser Gln Pro 370 375 380 <210> 83 <211> 1353 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1353) <400> 83 atg gac acc agg tct ctg tgg acc ctg gcc caa gcc cgg aag ccc tgg 48 Met Asp Thr Arg Ser Leu Trp Thr Leu Ala Gln Ala Arg Lys Pro Trp 1 5 10 15 gca ggc tcg act ctc ctg ctg gct gtg gag acc ctg gca tgc agc ctg 96 Ala Gly Ser Thr Leu Leu Leu Ala Val Glu Thr Leu Ala Cys Ser Leu 20 25 30 tgc cca cag gac cac ccc ttc gcc ttc agc tta ccc aat gtg ctg ctg 144 Cys Pro Gln Asp His Pro Phe Ala Phe Ser Leu Pro Asn Val Leu Leu 35 40 45 cag agc cag ctg ttt gga ccc acg ttt cct gct gac tac agc atc tcc 192 Gln Ser Gln Leu Phe Gly Pro Thr Phe Pro Ala Asp Tyr Ser Ile Ser 50 55 60 ttc cct act cgg ccc cca ctg cag gct cag att ccc agg cac tca ctg 240 Phe Pro Thr Arg Pro Pro Leu Gln Ala Gln Ile Pro Arg His Ser Leu 65 70 75 80 gcc cca ttg gtc cgt aat gga act gaa ata agt att act agc ctg gtg 288 Ala Pro Leu Val Arg Asn Gly Thr Glu Ile Ser Ile Thr Ser Leu Val 85 90 95 ctg cga aaa ctg gac cac ctt ctg ccc tca aac tat gga caa ggg ctg 336 Leu Arg Lys Leu Asp His Leu Leu Pro Ser Asn Tyr Gly Gln Gly Leu 100 105 110 ggg gat tcc ctc tat gcc act cct ggc ctg gtc ctt gtc att tcc atc 384 Gly Asp Ser Leu Tyr Ala Thr Pro Gly Leu Val Leu Val Ile Ser Ile 115 120 125 atg gca ggt gac cgg gcc ttc agc cag gga gag gtc atc atg gac ttt 432 Met Ala Gly Asp Arg Ala Phe Ser Gln Gly Glu Val Ile Met Asp Phe 130 135 140 ggg aac aca gat ggt tcc cct cac tgt gtc ttc tgg gat cac agt ctc 480 Gly Asn Thr Asp Gly Ser Pro His Cys Val Phe Trp Asp His Ser Leu 145 150 155 160 ttc cag ggc agg ggg ggt tgg tcc aaa gaa ggg tgc cag gca cag gtg 528 Phe Gln Gly Arg Gly Gly Trp Ser Lys Glu Gly Cys Gln Ala Gln Val 165 170 175 gcc agt gcc agc ccc act gct cag tgc ctc tgc cag cac ctc act gcc 576 Ala Ser Ala Ser Pro Thr Ala Gln Cys Leu Cys Gln His Leu Thr Ala 180 185 190 ttc tcc gtc ctc atg tcc cca cac act gtt ccg gaa gaa ccc gct ctg 624 Phe Ser Val Leu Met Ser Pro His Thr Val Pro Glu Glu Pro Ala Leu 195 200 205 gcg ctg ctg act caa gtg ggc ttg gga gct tcc ata ctg gcg ctg ctt 672 Ala Leu Leu Thr Gln Val Gly Leu Gly Ala Ser Ile Leu Ala Leu Leu 210 215 220 gtg tgc ctg ggt gtg tac tgg ctg gtg tgg aga gtc gtg gtg cgg aac 720 Val Cys Leu Gly Val Tyr Trp Leu Val Trp Arg Val Val Val Arg Asn 225 230 235 240 aag atc tcc tat ttc cgc cac gcc gcc ctg ctc aac atg gtg ttc tgc 768 Lys Ile Ser Tyr Phe Arg His Ala Ala Leu Leu Asn Met Val Phe Cys 245 250 255 ttg ctg gcc gca gac act tgc ttc ctg ggc gcc cca ttc ctc tct cca 816 Leu Leu Ala Ala Asp Thr Cys Phe Leu Gly Ala Pro Phe Leu Ser Pro 260 265 270 ggg ccc cga agc ccg ctc tgc ctt gtg ccg cct tcc tct gtc att tcc 864 Gly Pro Arg Ser Pro Leu Cys Leu Val Pro Pro Ser Ser Val Ile Ser 275 280 285 tct acc tgg cca cct ttt tct gga tgt ggc gca ggc cct ggt gtt ggc 912 Ser Thr Trp Pro Pro Phe Ser Gly Cys Gly Ala Gly Pro Gly Val Gly 290 295 300 cca cca gct gct ctt tgt ctt tca cca gct ggc aaa gca ccg agt tct 960 Pro Pro Ala Ala Leu Cys Leu Ser Pro Ala Gly Lys Ala Pro Ser Ser 305 310 315 320 ccc cct cat ggt gct cct ggg cta cct gtg ccc act ggg gtt ggc agg 1008 Pro Pro His Gly Ala Pro Gly Leu Pro Val Pro Thr Gly Val Gly Arg 325 330 335 tgt cac cct ggg gct cta cct acc tca agg gca ata cct gag gga ggg 1056 Cys His Pro Gly Ala Leu Pro Thr Ser Arg Ala Ile Pro Glu Gly Gly 340 345 350 gga atg ctg gtt gga tgg gaa ggg agg ggc gtt ata cac ctt cgt ggg 1104 Gly Met Leu Val Gly Trp Glu Gly Arg Gly Val Ile His Leu Arg Gly 355 360 365 cca gtg ctg gcc atc ata ggc gtg aat ggg ctg gta cta gcc atg gcc 1152 Pro Val Leu Ala Ile Ile Gly Val Asn Gly Leu Val Leu Ala Met Ala 370 375 380 atg ctg aag ttg ctg aga cct tcg ctg tca gag gga ccc cca gca gag 1200 Met Leu Lys Leu Leu Arg Pro Ser Leu Ser Glu Gly Pro Pro Ala Glu 385 390 395 400 aag cgc caa gct ctg ctg ggg gtg atc aaa gcc ctg ctc att ctt aca 1248 Lys Arg Gln Ala Leu Leu Gly Val Ile Lys Ala Leu Leu Ile Leu Thr 405 410 415 ccc atc ttt ggc ctc acc tgg ggc tgg cct ggc cac tct gtt aga gga 1296 P ro Ile Phe Gly Leu Thr Trp Gly Trp Pro Gly His Ser Val Arg Gly 420 425 430 agt ctc cac ggt ccc tca tta cat ctt cac cat tct caa cac cct cca 1344 Ser Leu His Gly Pro Ser Leu His Leu His His Ser Gln His Pro Pro 435 440 445 ggt agg tga 1353 Gly Arg 450 <210> 84 <211> 450 <212> PRT <213> Homo sapiens <400> 84 Met Asp Thr Arg Ser Leu Trp Thr Leu Ala Gln Ala Arg Lys Pro Trp 1 5 10 15 Ala Gly Ser Thr Leu Leu Leu Ala Val Glu Thr Leu Ala Cys Ser Leu 20 25 30 Cys Pro Gln Asp His Pro Phe Ala Phe Ser Leu Pro Asn Val Leu Leu 35 40 45 Gln Ser Gln Leu Phe Gly Pro Thr Phe Pro Ala Asp Tyr Ser Ile Ser 50 55 60 P he Pro Thr Arg Pro Pro Leu Gln Ala Gln Ile Pro Arg His Ser Leu 65 70 75 80 Ala Pro Leu Val Arg Asn Gly Thr Glu Ile Ser Ile Thr Ser Leu Val 85 90 95 Leu Arg Lys Leu Asp His Leu Leu Pro Ser Asn Tyr Gly Gln Gly Leu 100 105 110 Gly Asp Ser Leu Tyr Ala Thr Pro Gly Leu Val Leu Val Ile Ser Ile 115 120 125 Met Ala Gly Asp Arg Ala Phe Ser Gln Gly Glu Val Ile Met Asp Phe 130 135 140 Gly Asn Thr Asp Gly Ser Pro His Cys Val Phe Trp Asp His Ser Leu 145 150 155 160 Phe Gln Gly Arg Gly Gly Trp Ser Lys Glu Gly Cys Gln Ala Gln Val 165 170 175 Ala Ser Ala Ser Pro Thr Ala Gln Cys Leu Cys Gln His Leu Thr Ala 180 185 190 Phe Ser Val Leu Met Ser Pro His Thr Val Pro Glu Glu Pro Ala Leu 195 200 205 Ala Leu Leu Thr Gln Val Gly Leu Gly Ala Ser Ile Leu Ala Leu Leu 210 215 220 Val Cys Leu Gly Val Tyr Trp Leu Val Trp Arg Val Val Val Arg Asn 225 230 235 240 Lys Ile Ser Tyr Phe Arg His Ala Ala Leu Leu Asn Met Val Phe Cys 245 250 255 Leu Leu Ala Ala Asp Thr Cys Phe Leu Gly Ala Pro Phe Leu Ser Pro 260 265 270 Gly Pro Arg Ser Pro Leu Cys Leu Val Pro Pro Ser Ser Val Ile Ser 275 280 285 Ser Thr Trp Pro Pro Phe Ser Gly Cys Gly Ala Gly Pro Gly Val Gly 290 295 300 Pro Pro Ala Ala Leu Cys Leu Ser Pro Ala Gly Lys Ala Pro Ser Ser 305 310 315 320 Pro Pro His Gly Ala Pro Gly Leu Pro Val Pro Thr Gly Val Gly Arg 325 330 335 Cys His Pro Gly Ala Leu Pro Thr Ser Arg Ala Ile Pro Glu Gly Gly 340 345 350 Gly Met Leu Val Gly Trp Glu Gly Arg Gly Val Ile His Leu Arg Gly 355 360 365 Pro Val Leu Ala Ile Ile Gly Val Asn Gly Leu Val Leu Ala Met Ala 370 375 380 Met Leu Lys Leu Leu Arg Pro Ser Leu Ser Glu Gly Pro Pro Ala Glu 385 390 395 400 Lys Arg Gln Ala Leu Leu Gly Val Ile Lys Ala Leu Leu Ile Leu Thr 405 410 415 Pro Ile Phe Gly Leu Thr Trp Gly Trp Pro Gly His Ser Val Arg Gly 420 425 430 Ser Leu His Gly Pro Ser Leu His Leu His His Ser Gln His Pro Pro 435 440 445 Gly Arg 450 <210> 85 <211> 882 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(882) <400> 85 atg tct att ttc act ttt ctc tcc tct ccc gtt ctc ttt ttt cct ctt 48 Met Ser Ile Phe Thr Phe Leu Ser Ser Pro Val Leu Phe Phe Pro Leu 1 5 10 15 cct ggt tcg ttg tct tct cgc gcc gtc ccc ccg ccc gcc ccg tcg ttc 96 Pro Gly Ser Leu Ser Ser Arg Ala Val Pro Pro Pro Ala Pro Ser Phe 20 25 30 tct ttt tta ttg tat gcc gcg tct ttt ccg ctt cct cta ttt ctt cct 144 Ser Phe Leu Leu Tyr Ala Ala Ser Phe Pro Leu Pro Leu Phe Leu Pro 35 40 45 ccc ctc tgc cct tct ttt tcc gcc gtc cgg att gtt tcg ctc ccg ctt 192 Pro Leu Cys Pro Ser Phe Ser Ala Val Arg Ile Val Ser Leu Pro Leu 50 55 60 ctt tct gtc gct gct ctt cgt gtc ttc cgc tcg ccc cgt cgt ctt ttt 240 Leu Ser Val Ala Ala Leu Arg Val Phe Arg Ser Pro Arg Arg Leu Phe 65 70 75 80 ttg gtc cga ctt ttg tcc cgc tgt tct gtc cct cct cat ctc ctt tct 288 Leu Val Arg Leu Leu Ser Arg Cys Ser Val Pro Pro His Leu Leu Ser 85 90 95 c tc gtc gtc cct ctc cac ttc gct ctc gcc gtc ctt ttt cct cct ctc 336 Leu Val Val Pro Leu His Phe Ala Leu Ala Val Leu Phe Pro Pro Leu 100 105 110 ccc ttc ctc ccg ctc ctt cct ccg ttc cgc ttg tcg ccg ctg ttg ttt 384 Pro Phe Leu Pro Leu Leu Pro Pro Phe Arg Leu Ser Pro Leu Leu Phe 115 120 125 gtt ctt tgt gcg ccc ctc tgt ttt ttc ccc tat tgt tgt ttc tcc tcg 432 Val Leu Cys Ala Pro Leu Cys Phe Phe Pro Tyr Cys Cys Phe Ser Ser 130 135 140 tct tgt cct ttc tgc tct ctg cgt gcg atc cgc cgc ccc ttt ttc ctc 480 Ser Cys Pro Phe Cys Ser Leu Arg Ala Ile Arg Arg Pro Phe Phe Leu 145 150 155 160 gcc ccc tct tat ttc gtc tct ttt ttt ctc cgc ctc gtc ccg ttc gtg 528 Ala Pro Ser Tyr Phe Val Ser Phe Phe Leu Arg Leu Val Pro Phe Val 165 170 175 ccg cgt tat cct tcg gcc ttg ttt ctt cgc gct tct ttt ttc cga cct 576 Pro Arg Tyr Pro Ser Ala Leu Phe Leu Arg Ala Ser Phe Phe Arg Pro 180 185 190 ccg ttt tcg tgt tcg ctt tca tct ccc ctt ttt ttc acc ttt tcc tct 624 Pro Phe Ser Cys Ser Leu Ser Ser Pro Leu Phe Phe Thr Phe Ser Ser 195 200 205 ntt ctt cgt ctg ccc ccg gtc tcc tcc ttg tnt ctt tnn nnn nnn nnn 672 Xaa Leu Arg Leu Pro Pro Val Ser Ser Leu Xaa Leu Xaa Xaa Xaa Xaa 210 215 220 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 720 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 225 230 235 240 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn ttg cat 768 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu His 245 250 255 gca ttg nnc atn ngn nnn nnn ngc ttn aaa ngn ncn nnt ntg gcn aan 816 Ala Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Xaa Xaa Xaa Xaa Ala Xaa 260 265 270 ttt ttg naa tat tat nnn ttt ttt cag aca aaa aac acc aaa aaa att 864 Phe Leu Xaa Tyr Tyr Xaa Phe Phe Gln Thr Lys Asn Thr Lys Lys Ile 275 280 285 ttt tgg ggc ccc aca taa 882 Phe Trp Gly Pro Thr 290 <210> 86 <211> 293 <212> PRT <213> Homo sapiens <400> 86 Met Ser Ile Phe Thr Phe Leu Ser Ser Pro Val Leu Phe Phe Pro Leu 1 5 10 15 Pro Gly Ser Leu Ser Ser Arg Ala Val Pro Pro Pro Ala Pro Ser Phe 20 25 30 Ser Phe Leu Leu Tyr Ala Ala Ser Phe Pro Leu Pro Leu Phe Leu Pro 35 40 45 Pro Leu Cys Pro Ser Phe Ser Ala Val Arg Ile Val Ser Leu Pro Leu 50 55 60 Leu Ser Val Ala Ala Leu Arg Val Phe Arg Ser Pro Arg Arg Leu Phe 65 70 75 80 Leu Val Arg Leu Leu Ser Arg Cys Ser Val Pro Pro His Leu Leu Ser 85 90 95 Leu Val Val Pro Leu His Phe Ala Leu Ala Val Leu Phe Pro Pro Leu 100 105 110 Pro Phe Leu Pro Leu Leu Pro Pro Phe Arg Leu Ser Pro Leu Leu Phe 115 120 125 Val Leu Cys Ala Pro Leu Cys Phe Phe Pro Tyr Cys Cys Phe Ser Ser 130 135 140 Ser Cys Pro Phe Cys Ser Leu Arg Ala Ile Arg Arg Pro Phe Phe Leu 145 150 155 160 Ala Pro Ser Tyr Phe Val Ser Phe Phe Leu Arg Leu Val Pro Phe Val 165 170 175 Pro Arg Tyr Pro Ser Ala Leu Phe Leu Arg Ala Ser Phe Phe Arg Pro 180 185 190 Pro Phe Ser Cys Ser Leu Ser Ser Pro Leu Phe Phe Thr Phe Ser Ser 195 200 205 Xaa Leu Arg Leu Pro Pro Val Ser Ser Leu Xaa Leu Xaa Xaa Xaa Xaa 210 215 220 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 225 230 235 240 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu His 245 250 255 Ala Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Xaa Xaa Xaa Xaa Ala Xaa 260 265 270 Phe Leu Xaa Tyr Tyr Xaa Phe Phe Gln Thr Lys Asn Thr Lys Lys Ile 275 280 285 Phe Trp Gly Pro Thr 290 <210> 87 <211> 735 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(735) <400> 87 atg aat gct tcc aga tgc ctg tct gag gaa gtg ggg tcc ctc cgc cct 48 Met Asn Ala Ser Arg Cys Leu Ser Glu Glu Val Gly Ser Leu Arg Pro 1 5 10 15 cta acc atg gct gtc ctg tct gcc tcc ttt gtc gtc gga gtg ctg ggc 96 Leu Thr Met Ala Val Leu Ser Ala Ser Phe Val Val Gly Val Leu Gly 20 25 30 aat ggg ctg gtg ccg tgg gtg act gtc ttc cgc atg gcc cgc aca gtc 144 Asn Gly Leu Val Pro Trp Val Thr Val Phe Arg Met Ala Arg Thr Val 35 40 45 tcc acc gtc tgc ttc ttc cac ctg gcc ctt gcc gat ttc atg ctc tca 192 Ser Thr Val Cys Phe Phe His Leu Ala Leu Ala Asp Phe Met Leu Ser 50 55 60 ctg tct ctg ccc atc ctc gtg tac tat att gtc tcc agg cag tgg ctc 240 Leu Ser Leu Pro Ile Leu Val Tyr Tyr Ile Val Ser Arg Gln Trp Leu 65 70 75 80 ctt gga gag tgg gcc tgc aaa ctc tac acc ggt ttt gtg ttc ctc acc 288 Leu Gly Glu Trp Ala Cys Lys Leu Tyr Thr Gly Phe Val Phe Leu Thr 85 90 95 ttc tcc acc agt aac tgc ctc ctg gtc ctc atc tct gtg gac cgt tgc 336 Phe Ser Thr Ser Asn Cys Leu Leu Val Leu Ile Ser Val Asp Arg Cys 100 105 110 atc tct gtc ctc tac ccc gtc tgg gcc ctg aac cac cgc act gag cag 384 Ile Ser Val Leu Tyr Pro Val Trp Ala Leu Asn His Arg Thr Glu Gln 115 120 125 agg gcg agc tgg ctg gcc ttc ggg gtg tgg ctc ctg gcc gcc gcc ttg 432 Arg Ala Ser Trp Leu Ala Phe Gly Val Trp Leu Leu Ala Ala Ala Leu 130 135 140 tgc tct gcg cac ctg aaa ttc cgg aca acc aga aaa tgg aat ggc tgt 480 Cys Ser Ala His Leu Lys Phe Arg Thr Thr Arg Lys Trp Asn Gly Cys 145 150 155 160 atg cag tgc tac tta cag ttc aac ttg gag aat gag act gcc cag atg 528 Met Gln Cys Tyr Leu Gln Phe Asn Leu Glu Asn Glu Thr Ala Gln Met 165 170 175 tgg act cag gag gtc ttt ggg aga caa atg gcg gtg atc atg gcc cac 576 Trp Thr Gln Glu Val Phe Gly Arg Gln Met Ala Val Ile Met Ala His 180 185 190 ttc ctg ctg ggc ttc ctg ggg ccc tta gca atc ata ggc acc tgc gcc 624 Phe Leu Leu Gly Phe Leu Gly Pro Leu Ala Ile Ile Gly Thr Cys Ala 195 200 205 cac ctc atc cgg gcc aag ctc ttg cgg gag ggc tgg gtc cat gcc aac 672 His Leu Ile Arg Ala Lys Leu Leu Arg Glu Gly Trp Val His Ala Asn 210 215 220 cgg ccc aag agg ctg ctg ctg gtg ctg gtg agc gct tta tct gct ggt 720 Arg Pro Lys Arg Leu Leu Leu Val Leu Val Ser Ala Leu Ser Ala Gly 225 230 235 240 tcc cat tta acg tga 735 Ser His Leu Thr 245 <210> 88 <211> 244 <212> PRT <213> Homo sapiens <400> 88 Met Asn Ala Ser Arg Cys Leu Ser Glu Glu Val Gly Ser Leu Arg Pro 1 5 10 15 Leu Thr Met Ala Val Leu Ser Ala Ser Phe Val Val Gly Val Leu Gly 20 25 30 Asn Gly Leu Val Pro Trp Val Thr Val Phe Arg Met Ala Arg Thr Val 35 40 45 Ser Thr Val Cys Phe Phe His Leu Ala Leu Ala Asp Phe Met Leu Ser 50 55 60 Leu Ser Leu Pro Ile Leu Val Tyr Tyr Ile Val Ser Arg Gln Trp Leu 65 70 75 80 Leu Gly Glu Trp Ala Cys Lys Leu Tyr Thr Gly Phe Val Phe Leu Thr 85 90 95 Phe Ser Thr Ser Asn Cys Leu Leu Val Leu Ile Ser Val Asp Arg Cys 100 105 110 Ile Ser Val Leu Tyr Pro Val Trp Ala Leu Asn His Arg Thr Glu Gln 115 120 125 Arg Ala Ser Trp Leu Ala Phe Gly Val Trp Leu Leu Ala Ala Ala Leu 130 135 140 Cys Ser Ala His Leu Lys Phe Arg Thr Thr Arg Lys Trp Asn Gly Cys 145 150 155 160 Met Gln Cys Tyr Leu Gln Phe Asn Leu Glu Asn Glu Thr Ala Gln Met 165 170 175 Trp Thr Gln Glu Val Phe Gly Arg Gln Met Ala Val Ile Met Ala His 180 185 190 Phe Leu Leu Gly Phe Leu Gly Pro Leu Ala Ile Ile Gly Thr Cys Ala 195 200 205 His Leu Ile Arg Ala Lys Leu Leu Arg Glu Gly Trp Val His Ala Asn 210 215 220 Arg Pro Lys Arg Leu Leu Leu Val Leu Val Ser Ala Leu Ser Ala Gly 225 230 235 240 Ser His Leu Thr <210> 89 <211> 1527 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1527) <400> 89 atg acg tcc acc tgc acc aac agc acg cgc gag agt aac agc agc cac 48 Met Thr Ser Thr Cys Thr Asn Ser Thr Arg Glu Ser Asn Ser Ser His 1 5 10 15 acg tgc atg ccc ctc tcc aaa atg ccc atc agc ctg gcc cac ggc atc 96 Thr Cys Met Pro Leu Ser Lys Met Pro Ile Ser Leu Ala His Gly Ile 20 25 30 atc cgc tca acc gtg ctg gtt atc ttc ctc gcc gcc tct ttc gtc ggc 144 Ile Arg Ser Thr Val Leu Val Ile Phe Leu Ala Ala Ser Phe Val Gly 35 40 45 aac ata gtg ctg gcg cta gtg ttg cag cgc aag ccg cag ctg ctg cag 192 Asn Ile Val Leu Ala Leu Val Leu Gln Arg Lys Pro Gln Leu Leu Gln 50 55 60 gtg acc aac cgt ttt atc ttt aac ctc ctc gtc acc gac ctg ctg cag 240 Val Thr Asn Arg Phe Ile Phe Asn Leu Leu Val Thr Asp Leu Leu Gln 65 70 75 80 att tcg ctc gtg gcc ccc tgg gtg gtg gcc acc tct gtg cct ctc ttc 288 Ile Ser Leu Val Ala Pro Trp Val Val Ala Thr Ser Val Pro Leu Phe 85 90 95 tgg ccc ctc aac agc cac ttc tgc acg gcc ctg gtt agc ctc acc cac 336 Trp Pro Leu Asn Ser His Phe Cys Thr Ala Leu Val Ser Leu Thr His 100 105 110 ctg ttc gcc ttc gcc agc gtc aac acc att gtc gtg gtg tca gtg gat 384 Leu Phe Ala Phe Ala Ser Val Asn Thr Ile Val Val Val Ser Val Asp 115 120 125 cgc tac ttg tcc atc atc cac cct ctc tcc tac ccg tcc aag atg acc 432 Arg Tyr Leu Ser Ile Ile His Pro Leu Ser Tyr Pro Ser Lys Met Thr 130 135 140 cag cgc cgc ggt tac ctg ctc ctc tat ggc acc tgg att gtg gcc atc 480 Gln Arg Arg Gly Tyr Leu Leu Leu Tyr Gly Thr Trp Ile Val Ala Ile 145 150 155 160 ctg cag agc act cct cca ctc tac ggc tgg ggc cag gct gcc ttt gat 528 Leu Gln Ser Thr Pro Pro Leu Tyr Gly Trp Gly Gln Ala Ala Phe Asp 165 170 175 gag cgc aat gct ctc tgc tcc atg atc tgg ggg gcc agc ccc agc tac 576 Glu Arg Asn Ala Leu Cys Ser Met Ile Trp Gly Ala Ser Pro Ser Tyr 180 185 190 act att ctc agc gtg gtg tcc ttc atc gtc att cca ctg att gtc atg 624 Thr Ile Leu Ser Val Val Ser Phe Ile Val Ile Pro Leu Ile Val Met 195 200 205 att gcc tgc tac tcc gtg gtg ttc tgt gca gcc cgg agg cag cat gct 672 Ile Ala Cys Tyr Ser Val Val Phe Cys Ala Ala Arg Arg Gln His Ala 210 215 220 ctg ctg tac aat gtc aag aga cac agc ttg gaa gtg cga gtc aag gac 720 Leu Leu Tyr Asn Val Lys Arg His Ser Leu Glu Val Arg Val Lys Asp 225 230 235 240 tgt gtg gag aat gag gat gaa gag gga gca gag aag aag gag gag ttc 768 Cys Val Glu Asn Glu Asp Glu Glu Gly Ala Glu Lys Lys Glu Glu Phe 245 250 255 cag gat gag agt gag ttt cgc cgc cag cat gaa ggt gag gtc aag gcc 816 Gln Asp Glu Ser Glu Phe Arg Arg Gln His Glu Gly Glu Val Lys Ala 260 265 270 aag gag ggc aga atg gaa gcc aag gac ggc agc ctg aag gcc aag gaa 864 Ly s Glu Gly Arg Met Glu Ala Lys Asp Gly Ser Leu Lys Ala Lys Glu 275 280 285 gga agc acg ggg acc agt gag agt agt gta gag gcc agg ggc agc gag 912 Gly Ser Thr Gly Thr Ser Glu Ser Ser Val Glu Ala Arg Gly Ser Glu 290 295 300 gag gtc aga gag agc agc acg gtg gcc agc gac ggc agc atg gag ggt 960 Glu Val Arg Glu Ser Ser Thr Val Ala Ser Asp Gly Ser Met Glu Gly 305 310 315 320 aag gaa ggc agc acc aaa gtt gag gag aac agc atg aag gca gac aag 1008 Lys Glu Gly Ser Thr Lys Val Glu Glu Asn Ser Met Lys Ala Asp Lys 325 330 335 ggt cgc aca gag gtc aac cag tgc agc att gac ttg ggt gaa gat gac 1056 Gly Arg Thr Glu Val Asn Gln Cys Ser Ile Asp Leu Gly Glu Asp Asp 340 345 350 atg gag ttt ggt gaa gac gac atc aat ttc agt gag gat gac gtc gag 1104 Met Glu Phe Gly Glu Asp Asp Ile Asn Phe Ser Glu Asp Asp Val Glu 355 360 365 gca gtg aac atc ccg gag agc ctc cca ccc agt cgt cgt aac agc aac 1152 Ala Val Asn Ile Pro Glu Ser Leu Pro Pro Ser Arg Arg Asn Ser Asn 370 375 380 agc aac cct cct ctg ccc agg tgc tac cag tgc aaa gct gct aaa gtg 1200 Ser Asn Pro Pro Leu Pro Arg Cys Tyr Gln Cys Lys Ala Ala Lys Val 385 390 395 400 atc ttc atc atc att ttc tcc tat gtg cta tcc ctg ggg ccc tac tgc 1248 Ile Phe Ile Ile Ile Phe Ser Tyr Val Leu Ser Leu Gly Pro Tyr Cys 405 410 415 ttt tta gca gtc ctg gcc gtg tgg gtg gat gtc gaa acc cag gta ccc 1296 Phe Leu Ala Val Leu Ala Val Trp Val Asp Val Glu Thr Gln Val Pro 420 425 430 cag tgg gtg atc acc ata atc atc tgg ctt ttc ttc ctg cag tgc tgc 1344 Gln Trp Val Ile Thr Ile Ile Ile Trp Leu Phe Phe Leu Gln Cys Cys 435 440 445 atc cac ccc tat gtc tat ggc tac atg cac aag acc att aag aag gaa 1392 Ile His Pro Tyr Val Tyr Gly Tyr Met His Lys Thr Ile Lys Lys Glu 450 455 460 atc cag gac atg ctg aag aag ttc ttc tgc aag gaa aag ccc ccg aaa 1440 Ile Gln Asp Met Leu Lys Lys Phe Phe Cys Lys Glu Lys Pro Pro Lys 465 470 475 480 gaa gat agc cac cca gac ctg ccc gga aca gag ggt ggg act gaa ggc 1488 Glu Asp Ser His Pro Asp Leu Pro Gly Thr Glu Gly Gly Thr Glu Gly 485 490 495 aag att gtc cct tcc tac gat tct gct act ttt cct tga 1527 Lys Ile Val Pro Ser Tyr Asp Ser Ala Thr Phe Pro 500 505 <210> 90 <211> 508 <212> PRT <213> Homo sapiens <400> 90 Met Thr Ser Thr Cys Thr Asn Ser Thr Arg Glu Ser Asn Ser Ser His 1 5 10 15 Thr Cys Met Pro Leu Ser Lys Met Pro Ile Ser Leu Ala His Gly Ile 20 25 30 Ile Arg Ser Thr Val Leu Val Ile Phe Leu Ala Ala Ser Phe Val Gly 35 40 45 Asn Ile Val Leu Ala Leu Val Leu Gln Arg Lys Pro Gln Leu Leu Gln 50 55 60 Val Thr Asn Arg Phe Ile Phe Asn Leu Leu Val Thr Asp Leu Leu Gln 65 70 75 80 Ile Ser Leu Val Ala Pro Trp Val Val Ala Thr Ser Val Pro Leu Phe 85 90 95 Trp Pro Leu Asn Ser His Phe Cys Thr Ala Leu Val Ser Leu Thr His 100 105 110 Leu Phe Ala Phe Ala Ser Val Asn Thr Ile Val Val Val Ser Val Asp 115 120 125 Arg Tyr Leu Ser Ile Ile His Pro Leu Ser Tyr Pro Ser Lys Met Thr 130 135 140 Gln Arg Arg Gly Tyr Leu Leu Leu Tyr Gly Thr Trp Ile Val Ala Ile 145 150 155 160 Leu Gln Ser Thr Pro Pro Leu Tyr Gly Trp Gly Gln Ala Ala Phe Asp 165 170 175 Glu Arg Asn Ala Leu Cys Ser Met Ile Trp Gly Ala Ser Pro Ser Tyr 180 185 190 Thr Ile Leu Ser Val Val Ser Phe Ile Val Ile Pro Leu Ile Val Met 195 200 205 Ile Ala Cys Tyr Ser Val Val Phe Cys Ala Ala Arg Arg Gln His Ala 210 215 220 Leu Leu Tyr Asn Val Lys Arg His Ser Leu Glu Val Arg Val Lys Asp 225 230 235 240 Cys Val Glu Asn Glu Asp Glu Glu Gly Ala Glu Lys Lys Glu Glu Phe 245 250 255 Gln Asp Glu Ser Glu Phe Arg Arg Gln His Glu Gly Glu Val Lys Ala 260 265 270 Lys Glu Gly Arg Met Glu Ala Lys Asp Gly Ser Leu Lys Ala Lys Glu 275 280 285 Gl y Ser Thr Gly Thr Ser Glu Ser Ser Val Glu Ala Arg Gly Ser Glu 290 295 300 Glu Val Arg Glu Ser Ser Thr Val Ala Ser Asp Gly Ser Met Glu Gly 305 310 315 320 Lys Glu Gly Ser Thr Lys Val Glu Glu Asn Ser Met Lys Ala Asp Lys 325 330 335 Gly Arg Thr Glu Val Asn Gln Cys Ser Ile Asp Leu Gly Glu Asp Asp 340 345 350 Met Glu Phe Gly Glu Asp Asp Ile Asn Phe Ser Glu Asp Asp Val Glu 355 360 365 Ala Val Asn Ile Pro Glu Ser Leu Pro Pro Ser Arg Arg Asn Ser Asn 370 375 380 Ser Asn Pro Pro Leu Pro Arg Cys Tyr Gln Cys Lys Ala Ala Lys Val 385 390 395 400 Ile Phe Ile Ile Ile Phe Ser Tyr Val Leu Ser Leu Gly Pro Tyr Cys 405 410 415 Phe Leu Ala Val Leu Ala Val Trp Val Asp Val Glu Thr Gln Val Pro 420 425 430 Gln Trp Val Ile Thr Ile Ile Ile Trp Leu Phe Phe Leu Gln Cys Cys 435 440 445 Ile His Pro Tyr Val Tyr Gly Tyr Met His Lys Thr Ile Lys Lys Glu 450 455 460 Ile Gln Asp Met Leu Lys Lys Phe Phe Cys Lys Glu Lys Pro Pro Lys 465 470 475 480 Glu Asp Ser His Pro Asp Leu Pro Gly Thr Glu Gly Gly Thr Glu Gly 485 490 495 Lys Ile Val Pro Ser Tyr Asp Ser Ala Thr Phe Pro 500 505 <210> 91 <211> 1263 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1263) <400> 91 atg gtt ctc tgt tgt aga ggt tct ctg ttg tgg atg gtt ctc tgt tgt 48 Met Val Leu Cys Cys Arg Gly Ser Leu Leu Trp Met Val Leu Cys Cys 1 5 10 15 gga tgg ttc tct gtt aca gag ggt ctc tgt tgt gga ggg tct ctg ttg 96 Gly Trp Phe Ser Val Thr Glu Gly Leu Cys Cys Gly Gly Ser Leu Leu 20 25 30 tgg atg gtt ctc tgt tgt ggg tgg gtc tct gtt gtg ggt ggg tct ctg 144 Trp Met Val Leu Cys Cys Gly Trp Val Ser Val Val Gly Gly Ser Leu 35 40 45 ttg tgg agg gtt ctc tgt tgt gga ggg ttc tct gtt gtg gag ggt tct 192 Leu Trp Arg Val Leu Cys Cys Gly Gly Phe Ser Val Val Glu Gly Ser 50 55 60 ctg ttg tgg agg gtc tct gtt ggg gat ggt tct ctg ttg tgg agg ctc 240 Leu Leu Trp Arg Val Ser Val Gly Asp Gly Ser Leu Leu Trp Arg Leu 65 70 75 80 tct gtt gtg gag gtt ctc tgt tgt gga gga tct ctg ttg tgg atg gtt 288 Ser Val Val Glu Val Leu Cys Cys Gly Gly Ser Leu Leu Trp Met Val 85 90 95 ctg tgt tgt gga ggg ttc tgt gtt gtg gag ggt tct ctg ttg tgg agg 336 Leu Cys Cys Gly Gly Phe Cys Val Val Glu Gly Ser Leu Leu Trp Arg 100 105 110 gtc tct gtt gtg gat ggt tct ctg tcg tgg agg ctc tct gtc gtg gag 384 Val Ser Val Val Asp Gly Ser Leu Ser Trp Arg Leu Ser Val Val Glu 115 120 125 gct ccc tgt cgt gga ggc tct ctg tcg tgg agg gtc tct gtc gtg ggt 432 Ala Pro Cys Arg Gly Gly Ser Leu Ser Trp Arg Val Ser Val Val Gly 130 135 140 ggt tct ttg ttg tgg agg gtc tct gtt gtg gat ggt tct ctg ttg tgg 480 Gly Ser Leu Leu Trp Arg Val Ser Val Val Asp Gly Ser Leu Leu Trp 145 150 155 160 agg gtc tct gtt gtg gag ggt ctc tgt tgt gga ggg ttc tct gtt gtg 528 Arg Val Ser Val Val Glu Gly Leu Cys Cys Gly Gly Phe Ser Val Val 165 170 175 gag ggt ctc tgt tgt gga ggg ttc tct gtt gtg gag ggt tgt ctg ttg 576 Glu Gly Leu Cys Cys Gly Gly Phe Ser Val Val Glu Gly Cys Leu Leu 180 185 190 tgg agg gtt ctc tgt tgt gga gcg tct ctg ttg tgg aga gtc tct gtt 624 Trp Arg Val Leu Cys Cys Gly Ala Ser Leu Leu Trp Arg Val Ser Val 195 200 205 gtg gag ggt tct ctg ttg tgg aga gtc tgt tgt gga ggg ttc tct gtt 672 Val Glu Gly Ser Leu Leu Trp Arg Val Cys Cys Gly Gly Phe Ser Val 210 215 220 gtg gag agt ctc tgt tgt gga tgg ttc tct gtt gtg gag ggt tct ctg 720 Val Glu Ser Leu Cys Cys Gly Trp Phe Ser Val Val Glu Gly Ser Leu 225 230 235 240 ttg tgg agg gtt ctc tgt tgt gga tgg ttc tct gtt atg gag ggt tct 768 Leu Trp Arg Val Leu Cys Cys Gly Trp Phe Ser Val Met Glu Gly Ser 245 250 255 ctg ttg tgg agg gtt ctc tct tgt gga tgg ttc tct gtt gtg gat ggt 816 Leu Leu Trp Arg Val Leu Ser Cys Gly Trp Phe Ser Val Val Asp Gly 260 265 270 tct ctg tta tgg agg gtc tct gtt gtg gag ggt ctc tgt tgt gga gag 864 Ser Leu Leu Trp Arg Val Ser Val Val Glu Gly Leu Cys Cys Gly Glu 275 280 285 tct gtt gtg gat ggt tct ctg ttg tgg aga gtc tct gtt gtg gag ggt 912 Ser Val Val Asp Gly Ser Leu Leu Trp Arg Val Ser Val Val Glu Gly 290 295 300 ctc tgt tgt ggg tgg ttc ttt gtt gtg ggt ggt tct ctg ttg tgg atg 960 Leu Cys Cys Gly Trp Phe Phe Val Val Gly Gly Ser Leu Leu Trp Met 305 310 315 320 gtt ctt tgt tgt ggg tgg ttc tct gtt gtg aat ggt tct ttg ttg tgg 1008 Val Leu Cys Cys Gly Trp Phe Ser Val Val Asn Gly Ser Leu Leu Trp 325 330 335 atg ggt ctc tgt tgt gga ggg ttc tct gtt gtg gat ggg tct ctg ttg 1056 Met Gly Leu Cys Cys Gly Gly Phe Ser Val Val Asp Gly Ser Leu Leu 340 345 350 tgg atg gtt ctc tgt tgt gga tgg gtc tct gtt gtg gat ggg tct ctg 1104 Trp Met Val Leu Cys Cys Gly Trp Val Ser Val Val Asp Gly Ser Leu 355 360 365 ttg tgg agg gtc tct gtt gtg gat ggt tct ctg ttt tgg atg ggt ctc 1152 Leu Trp Arg Val Ser Val Val Asp Gly Ser Leu Phe Trp Met Gly Leu 370 375 380 tgt tgt gga ggt tct ctg ttg tgg aag ttc ttt gtt gta ttt gct gca 1200 Cys Cys Gly Gly Ser Leu Leu Trp Lys Phe Phe Val Val Phe Ala Ala 385 390 395 400 aat atg cat gat aag atg ctt agg agc atc tac cca cta gat gtc agt 1248 Asn Met His Asp Lys Met Leu Arg Ser Ile Tyr Pro Leu Asp Val Ser 405 410 415 agc agc ccc act tag 1263 Ser Ser Pro Thr 420 <210> 92 <211> 420 <212> PRT <213> Homo sapiens <400> 92 Met Val Leu Cys Cys Arg Gly Ser Leu Leu Trp Met Val Leu Cys Cys 1 5 10 15 Gly Trp Phe Ser Val Thr Glu Gly Leu Cys Cys Gly Gly Ser Leu Leu 20 25 30 Trp Met Val Leu Cys Cys Gly Trp Val Ser Val Val Gly Gly Ser Leu 35 40 45 Leu Trp Arg Val Leu Cys Cys Gly Gly Phe Ser Val Val Glu Gly Ser 50 55 60 Leu Leu Trp Arg Val Ser Val Gly Asp Gly Ser Leu Leu Trp Arg Leu 65 70 75 80 Ser Val Val Glu Val Leu Cys Cys Gly Gly Ser Leu Leu Trp Met Val 85 90 95 Leu Cys Cys Gly Gly Phe Cys Val Val Glu Gly Ser Leu Leu Trp Arg 100 105 110 Val Ser Val Val Asp Gly Ser Leu Ser Trp Arg Leu Ser Val Val Glu 115 120 125 Ala Pro Cys Arg Gly Gly Ser Leu Ser Trp Arg Val Ser Val Val Gly 130 135 140 Gly Ser Leu Leu Trp Arg Val Ser Val Val Asp Gly Ser Leu Leu Trp 145 150 155 160 Arg Val Ser Val Val Glu Gly Leu Cys Cys Gly Gly Phe Ser Val Val 165 170 175 Glu Gly Leu Cys Cys Gly Gly Phe Ser Val Val Glu Gly Cys Leu Leu 180 185 190 Trp Arg Val Leu Cys Cys Gly Ala Ser Leu Leu Trp Arg Val Ser Val 195 200 205 Val Glu Gly Ser Leu Leu Trp Arg Val Cys Cys Gly Gly Phe Ser Val 210 215 220 Val Glu Ser Leu Cys Cys Gly Trp Phe Ser Val Val Glu Gly Ser Leu 225 230 235 240 Leu Trp Arg Val Leu Cys Cys Gly Trp Phe Ser Val Met Glu Gly Ser 245 250 255 Leu Leu Trp Arg Val Leu Ser Cys Gly Trp Phe Ser Val Val Asp Gly 260 265 270 Ser Leu Leu Trp Arg Val Ser Val Val Glu Gly Leu Cys Cys Gly Glu 275 280 285 Ser Val Val Asp Gly Ser Leu Leu Trp Arg Val Ser Val Val Glu Gly 290 295 300 Leu Cys Cys Gly Trp Phe Phe Val Val Gly Gly Ser Leu Leu Trp Met 305 310 315 320 Val Leu Cys Cys Gly Trp Phe Ser Val Val Asn Gly Ser Leu Leu Trp 325 330 335 Met Gly Leu Cys Cys Gly Gly Phe Ser Val Val Asp Gly Ser Leu Leu 340 345 350 Trp Met Val Leu Cys Cys Gly Trp Val Ser Val Val Asp Gly Ser Leu 355 360 365 Leu Trp Arg Val Ser Val Val Asp Gly Ser Leu Phe Trp Met Gly Leu 370 375 380 Cys Cys Gly Gly Ser Leu Leu Trp Lys Phe Phe Val Val Phe Ala Ala 385 390 395 400 Asn Met His Asp Lys Met Leu Arg Ser Ile Tyr Pro Leu Asp Val Ser 405 410 415 Ser Ser Pro Thr 420 <210> 93 <211> 984 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(984) <400> 93 atg acg ccc aac agc act ggc gag gtg ccc agc ccc att ccc aag ggg 48 Met Thr Pro Asn Ser Thr Gly Glu Val Pro Ser Pro Ile Pro Lys Gly 1 5 10 15 gct ttg ggg ctc tcc ctg gcc ctg gca agc ctc atc atc acc gcg aac 96 Ala Leu Gly Leu Ser Leu Ala Leu Ala Ser Leu Ile Ile Thr Ala Asn 20 25 30 ctg ctc cta gcc ctg ggc atc gct ggg acc gcc gcc tgc gca gcc acc 144 Leu Leu Leu Ala Leu Gly Ile Ala Gly Thr Ala Ala Cys Ala Ala Thr 35 40 45 tgc tgg ctg ctt ctt cct gag cct act gct ggc tgg gct gct cac ggg 192 Cys Trp Leu Leu Leu Pro Glu Pro Thr Ala Gly Trp Ala Ala His Gly 50 55 60 tct ggc att gcc aca ttg cca ggg ctg tgg aac cag agt cgc cgg ggt 240 Ser Gly Ile Ala Thr Leu Pro Gly Leu Trp Asn Gln Ser Arg Arg Gly 65 70 75 80 tac tgg tcc tgc ctc ctc gtc tac ttg gct ccc aac ttc tcc ttc ctc 288 Tyr Trp Ser Cys Leu Leu Val Tyr Leu Ala Pro Asn Phe Ser Phe Leu 85 90 95 tcc ctg ctt gcc aac ctc ttg ctg gtg cac ggg gag cgc tac atg gca 336 Ser Leu Leu Ala Asn Leu Leu Leu Val His Gly Glu Arg Tyr Met Ala 100 105 110 gtc ctg agg cca ctc cag ccc cct ggg agc att cgg ctg gcc ctg ctc 384 Val Leu Arg Pro Leu Gln Pro Pro Gly Ser Ile Arg Leu Ala Leu Leu 115 120 125 ctc acc tgg gct ggt ccc ctg ctc ttt gcc agt ctg ccc gct ctg ggg 432 Leu Thr Trp Ala Gly Pro Leu Leu Phe Ala Ser Leu Pro Ala Leu Gly 130 135 140 tgg aac cac tgg acc cct ggt gcc aac tgc agc tcc cag gct atc ttc 480 Trp Asn His Trp Thr Pro Gly Ala Asn Cys Ser Ser Gln Ala Ile Phe 145 150 155 160 cca gcc ccc tac ctg tac ctc gaa gtc tat ggg ctc ctg ctg ccc gcc 528 Pro Ala Pro Tyr Leu Tyr Leu Glu Val Tyr Gly Leu Leu Leu Pro Ala 165 170 175 gtg ggt gct gct gcc ttc ctc tct gtc cgc gtg ctg gcc act gcc cac 576 Val Gly Ala Ala Ala Phe Leu Ser Val Arg Val Leu Ala Thr Ala His 180 185 190 cgc cag ctg cag gac atc tgc cgg ctg gag cgg gca gtg tgc cgc gat 624 Arg Gln Leu Gln Asp Ile Cys Arg Leu Glu Arg Ala Val Cys Arg Asp 195 200 205 gag ccc tcc gcc ctg gcc cgg gcc ctt acc tgg agg cag gca agg gca 672 Glu Pro Ser Ala Leu Ala Arg Ala Leu Thr Trp Arg Gln Ala Arg Ala 210 215 220 cag gct gga gcc atg ctg ctc ttc ggg ctg tgc tgg ggg ccc tac gtg 720 Gln Ala Gly Ala Met Leu Leu Phe Gly Leu Cys Trp Gly Pro Tyr Val 225 230 235 240 gcc aca ctg ctc ctc tca gtc ctg gcc tat gag cag cgc ccg cca ctg 768 Ala Thr Leu Leu Leu Ser Val Leu Ala Tyr Glu Gln Arg Pro Pro Leu 245 250 255 ggg cct ggg aca ctg ttg tcc ctc ctc tcc cta gga agt gcc agt gca 816 Gly Pro Gly Thr Leu Leu Ser Leu Leu Ser Leu Gly Ser Ala Ser Ala 260 265 270 gcg gca gtg ccc gta gcc atg ggg ctg ggc gat cag cgc tac aca gcc 864 Ala Ala Val Pro Val Ala Met Gly Leu Gly Asp Gln Arg Tyr Thr Ala 275 280 285 ccc tgg agg cag ccg ccc aaa ggt gcc tgc agg ggc tgt ggg gaa gag 912 Pro Trp Arg Gln Pro Pro Lys Gly Ala Cys Arg Gly Cys Gly Glu Glu 290 295 300 cct ccc ggg aca gtc ccg gcc cca gca ttg cct acc acc caa gca gcc 960 Pro Pro Gly Thr Val Pro Ala Pro Ala Leu Pro Thr Thr Gln Ala Ala 305 310 315 320 aaa gca gtg tcg acc tgg act tga 984 Lys Ala Val Ser Thr Trp Thr 325 <210> 94 <211> 327 <212> PRT <213> Homo sapiens <400> 94 Met Thr Pro Asn Ser Thr Gly Glu Val Pro Ser Pro Ile Pro Lys Gly 1 5 10 15 Ala Leu Gly Leu Ser Leu Ala Leu Ala Ser Leu Ile Ile Thr Ala Asn 20 25 30 Leu Leu Leu Ala Leu Gly Ile Ala Gly Thr Ala Ala Cys Ala Ala Thr 35 40 45 Cys Trp Leu Leu Leu Pro Glu Pro Thr Ala Gly Trp Ala Ala His Gly 50 55 60 Ser Gly Ile Ala Thr Leu Pro Gly Leu Trp Asn Gln Ser Arg Arg Gly 65 70 75 80 Tyr Trp Ser Cys Leu Leu Val Tyr Leu Ala Pro Asn Phe Ser Phe Leu 85 90 95 Ser Leu Leu Ala Asn Leu Leu Leu Val His Gly Glu Arg Tyr Met Ala 100 105 110 Val Leu Arg Pro Leu Gln Pro Pro Gly Ser Ile Arg Leu Ala Leu Leu 115 120 125 Leu Thr Trp Ala Gly Pro Leu Leu Phe Ala Ser Leu Pro Ala Leu Gly 130 135 140 Trp Asn His Trp Thr Pro Gly Ala Asn Cys Ser Ser Gln Ala Ile Phe 145 150 155 160 Pro Ala Pro Tyr Leu Tyr Leu Glu Val Tyr Gly Leu Leu Leu Pro Ala 165 170 175 Val Gly Ala Ala Ala Phe Leu Ser Val Arg Val Leu Ala Thr Ala His 180 185 190 Arg Gln Leu Gln Asp Ile Cys Arg Leu Glu Arg Ala Val Cys Arg Asp 195 200 205 Glu Pro Ser Ala Leu Ala Arg Ala Leu Thr Trp Arg Gln Ala Arg Ala 210 215 220 Gln Ala Gly Ala Met Leu Leu Phe Gly Leu Cys Trp Gly Pro Tyr Val 225 230 235 240 Ala Thr Leu Leu Leu Ser Val Leu Ala Tyr Glu Gln Arg Pro Pro Leu 245 250 255 Gly Pro Gly Thr Leu Leu Ser Leu Leu Ser Leu Gly Ser Ala Ser Ala 260 265 270 Ala Ala Val Pro Val Ala Met Gly Leu Gly Asp Gln Arg Tyr Thr Ala 275 280 285 Pro Trp Arg Gln Pro Pro Lys Gly Ala Cys Arg Gly Cys Gly Glu Glu 290 295 300 Pro Pro Gly Thr Val Pro Ala Pro Ala Leu Pro Thr Thr Gln Ala Ala 305 310 315 320 Lys Ala Val Ser Thr Trp Thr 325 <210> 95 <211> 909 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(909) <400> 95 atg tct cct gca gct gct gct gag cca gat ggg gac cag cag gac aga 48 Met Ser Pro Ala Ala Ala Ala Glu Pro Asp Gly Asp Gln Gln Asp Arg 1 5 10 15 cac gtc agc aaa ctc atc ttc tgc ttc ttt gtc ttc ggc gcc gtc ttg 96 His Val Ser Lys Leu Ile Phe Cys Phe Phe Val Phe Gly Ala Val Leu 20 25 30 ttg tgt gtg gga gtc ctg ctc tcc atc ttt ggg ttc cag gca tgc caa 144 Leu Cys Val Gly Val Leu Leu Ser Ile Phe Gly Phe Gln Ala Cys Gln 35 40 45 tat aag ccc ctc cca gac tgc ccc atg gtg ctc aag gtg gcg ggg cct 192 Tyr Lys Pro Leu Pro Asp Cys Pro Met Val Leu Lys Val Ala Gly Pro 50 55 60 gca tgt gcc gtg gtt ggg ctt ggg gct gtg atc ctg gcc cgc tcc cgg 240 Ala Cys Ala Val Val Gly Leu Gly Ala Val Ile Leu Ala Arg Ser Arg 65 70 75 80 gcg caa ctt cag ctc ggt gca ggg ctg cag aga ggt cag cag atg gac 288 Ala Gln Leu Gln Leu Gly Ala Gly Leu Gln Arg Gly Gln Gln Met Asp 85 90 95 ccc gac cga gcc ttc atc tgt gga gag agc cgc cag ttt gcc cag tgc 336 Pro Asp Arg Ala Phe Ile Cys Gly Glu Ser Arg Gln Phe Ala Gln Cys 100 105 110 ctt atc ttt ggg ttt ctg ttc ttg aca agc ggc atg ctc atc agc gtc 384 Leu Ile Phe Gly Phe Leu Phe Leu Thr Ser Gly Met Leu Ile Ser Val 115 120 125 ctg ggc att tgg gtc cct gga tgt ggc tcc aaa tgg gcg cag gaa ccg 432 Leu Gly Ile Trp Val Pro Gly Cys Gly Ser Lys Trp Ala Gln Glu Pro 130 135 140 cta aac gag aca gac act ggc gac tca gag ccc cgg atg tgt ggg ttc 480 Leu Asn Glu Thr Asp Thr Gly Asp Ser Glu Pro Arg Met Cys Gly Phe 145 150 155 160 ctt tct ctg cag atc atg ggg ccc ttg att gtg ctt gtg gga ttg tgt 528 Leu Ser Leu Gln Ile Met Gly Pro Leu Ile Val Leu Val Gly Leu Cys 165 170 175 ttc ttc gtg gtt gcc cat gtt aag aag aga aac acg ctg aat gct ggc 576 Phe Phe Val Val Ala His Val Lys Lys Arg Asn Thr Leu Asn Ala Gly 180 185 190 cag gat gcc tct gag aga gaa gag gga cag atc cag att atg gag cct 624 Gln Asp Ala Ser Glu Arg Glu Glu Gly Gln Ile Gln Ile Met Glu Pro 195 200 205 gtc cag gtc act gta ggt ggg ttg ctg tta ttt gcg ttc tgc ttc tat 672 Val Gln Val Thr Val Gly Gly Leu Leu Leu Phe Ala Phe Cys Phe Tyr 210 215 220 cac agt ggc ttt gca gca ggg ttt cac cag ctg ctc ttg gtt ctc gtc 720 His Ser Gly Phe Ala Ala Gly Phe His Gln Leu Leu Leu Val Leu Val 225 230 235 240 tgg att ctc ttt ctc aat tct tcc atc tct cac aca tgt gtg tgc aca 768 Trp Ile Leu Phe Leu Asn Ser Ser Ile Ser His Thr Cys Val Cys Thr 245 250 255 cgc aca cac ccc cat cat gtg tac ata cac aat ggt gct gct gtg gga 816 Arg Thr His Pro His His Val Tyr Ile His Asn Gly Ala Ala Val Gly 260 265 270 agc ccc gta gga acc ttg tat aca tct ttt ccc ccc cag caa ctc ttt 864 Ser Pro Val Gly Thr Leu Tyr Thr Ser Phe Pro Pro Gln Gln Leu Phe 275 280 285 cct act ttg caa agc att ggg ata tta agt agt gac ctt gac tga 909 Pro Thr Leu Gln Ser Ile Gly Ile Leu Ser Ser Asp Leu Asp 290 295 300 <210> 96 <211> 302 <212> PRT <213> Homo sapiens <400> 96 Met Ser Pro Ala Ala Ala Ala Glu Pro Asp Gly Asp Gln Gln Asp Arg 1 5 10 15 His Val Ser Lys Leu Ile Phe Cys Phe Phe Val Phe Gly Ala Val Leu 20 25 30 Leu Cys Val Gly Val Leu Leu Ser Ile Phe Gly Phe Gln Ala Cys Gln 35 40 45 Tyr Lys Pro Leu Pro Asp Cys Pro Met Val Leu Lys Val Ala Gly Pro 50 55 60 Ala Cys Ala Val Val Gly Leu Gly Ala Val Ile Leu Ala Arg Ser Arg 65 70 75 80 Ala Gln Leu Gln Leu Gly Ala Gly Leu Gln Arg Gly Gln Gln Met Asp 85 90 95 Pro Asp Arg Ala Phe Ile Cys Gly Glu Ser Arg Gln Phe Ala Gln Cys 100 105 110 Leu Ile Phe Gly Phe Leu Phe Leu Thr Ser Gly Met Leu Ile Ser Val 115 120 125 Leu Gly Ile Trp Val Pro Gly Cys Gly Ser Lys Trp Ala Gln Glu Pro 130 135 140 Leu Asn Glu Thr Asp Thr Gly Asp Ser Glu Pro Arg Met Cys Gly Phe 145 150 155 160 Leu Ser Leu Gln Ile Met Gly Pro Leu Ile Val Leu Val Gly Leu Cys 165 170 175 Phe Phe Val Val Ala His Val Lys Lys Arg Asn Thr Leu Asn Ala Gly 180 185 190 Gln Asp Ala Ser Glu Arg Glu Glu Gly Gln Ile Gln Ile Met Glu Pro 195 200 205 Val Gln Val Thr Val Gly Gly Leu Leu Leu Phe Ala Phe Cys Phe Tyr 210 215 220 His Ser Gly Phe Ala Ala Gly Phe His Gln Leu Leu Leu Val Leu Val 225 230 235 240 Trp Ile Leu Phe Leu Asn Ser Ser Ile Ser His Thr Cys Val Cys Thr 245 250 255 Arg Thr His Pro His His Val Tyr Ile His Asn Gly Ala Ala Val Gly 260 265 270 Ser Pro Val Gly Thr Leu Tyr Thr Ser Phe Pro Pro Gln Gln Leu Phe 275 280 285 Pro Thr Leu Gln Ser Ile Gly Ile Leu Ser Ser Asp Leu Asp 290 295 300 <210> 97 <211> 708 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(708) <400> 97 atg gac tac aag tcc cgg cag gcc ccg ctc tgg ctc gga ctc tgg gtg 48 Met Asp Tyr Lys Ser Arg Gln Ala Pro Leu Trp Leu Gly Leu Trp Val 1 5 10 15 ggt ctg ggt ctc cgg ccg act ttc cgt gtc tgc tcc ccg agt ctc tgc 96 Gly Leu Gly Leu Arg Pro Thr Phe Arg Val Cys Ser Pro Ser Leu Cys 20 25 30 ggg ccg ctt tgg ccc cgc tct gcc agt ctg tgt gtg tgg ggg tct gtc 144 Gly Pro Leu Trp Pro Arg Ser Ala Ser Leu Cys Val Trp Gly Ser Val 35 40 45 tct gag act ctt tgc ctg tct ctg ggt ctc tgt ccc tct ttc tcc gcc 192 Ser Glu Thr Leu Cys Leu Ser Leu Gly Leu Cys Pro Ser Phe Ser Ala 50 55 60 gct gac cgg ctg tct cgc ccc agt tgt gcc tgt gtg tgt ggt ggg ggt 240 Ala Asp Arg Leu Ser Arg Pro Ser Cys Ala Cys Val Cys Gly Gly Gly 65 70 75 80 gtc tct gcc tct gcc cct tcc tat ctc tgc ctg tct ccc ttt atc tct 288 Val Ser Ala Ser Ala Pro Ser Tyr Leu Cys Leu Ser Pro Phe Ile Ser 85 90 95 ctg cct ctc att tct ctt gct gcc tgt gcg tct ctg agt ctt ctt tgc 336 Leu Pro Leu Ile Ser Leu Ala Ala Cys Ala Ser Leu Ser Leu Leu Cys 100 105 110 ctg tct ctc cct gcg tgt ctc tct ctc tgt ctc tgt gga gtc tct cga 384 Leu Ser Leu Pro Ala Cys Leu Ser Leu Cys Leu Cys Gly Val Ser Arg 115 120 125 cct ctg tcg ctc act tct gtc tct tta tcc ttt ttc tta ggg gct cca 432 Pro Leu Ser Leu Thr Ser Val Ser Leu Ser Phe Phe Leu Gly Ala Pro 130 135 140 ttg cgt ccc tgc tcg gcc ctt ggg aca gcc ctg ggg ccc ggt ttg ttt 480 Leu Arg Pro Cys Ser Ala Leu Gly Thr Ala Leu Gly Pro Gly Leu Phe 145 150 155 160 tgt gct ttg gca ccc agg agg gtg aga gag tta gtg ggg gcg agg cag 528 Cys Ala Leu Ala Pro Arg Arg Val Arg Glu Leu Val Gly Ala Arg Gln 165 170 175 ctg tgg ggg gtg cgg ctg gga aat ccc ttc aag gag ctt ctc ctt cct 576 Leu Trp Gly Val Arg Leu Gly Asn Pro Phe Lys Glu Leu Leu Leu Pro 180 185 190 tcc ccc act gct cca ggc tct gcc ttg ccc tgc tct gcc ctg ccc ggg 624 Ser Pro Thr Ala Pro Gly Ser Ala Leu Pro Cys Ser Ala Leu Pro Gly 195 200 205 gct ccg agt cca ggg gac atg cct ggc tgt gta cta cac tgc act tcg 672 Ala Pro Ser Pro Gly Asp Met Pro Gly Cys Val Leu His Cys Thr Ser 210 215 220 cat cgt ggg gcc tca gtt tcc cta gct gtg aaa tga 708 His Arg Gly Ala Ser Val Ser Leu Ala Val Lys 225 230 235 <210> 98 <211> 235 <212> PRT <213> Homo sapiens <400> 98 Met Asp Tyr Lys Ser Arg Gln Ala Pro Leu Trp Leu Gly Leu Trp Val 1 5 10 15 Gly Leu Gly Leu Arg Pro Thr Phe Arg Val Cys Ser Pro Ser Leu Cys 20 25 30 Gly Pro Leu Trp Pro Arg Ser Ala Ser Leu Cys Val Trp Gly Ser Val 35 40 45 Ser Glu Thr Leu Cys Leu Ser Leu Gly Leu Cys Pro Ser Phe Ser Ala 50 55 60 Ala Asp Arg Leu Ser Arg Pro Ser Cys Ala Cys Val Cys Gly Gly Gly 65 70 75 80 Val Ser Ala Ser Ala Pro Ser Tyr Leu Cys Leu Ser Pro Phe Ile Ser 85 90 95 Leu Pro Leu Ile Ser Leu Ala Ala Cys Ala Ser Leu Ser Leu Leu Cys 100 105 110 Leu Ser Leu Pro Ala Cys Leu Ser Leu Cys Leu Cys Gly Val Ser Arg 115 120 125 Pro Leu Ser Leu Thr Ser Val Ser Leu Ser Phe Phe Leu Gly Ala Pro 130 135 140 Leu Arg Pro Cys Ser Ala Leu Gly Thr Ala Leu Gly Pro Gly Leu Phe 145 150 155 160 Cys Ala Leu Ala Pro Arg Arg Val Arg Glu Leu Val Gly Ala Arg Gln 165 170 175 Leu Trp Gly Val Arg Leu Gly Asn Pro Phe Lys Glu Leu Leu Leu Pro 180 185 190 Ser Pro Thr Ala Pro Gly Ser Ala Leu Pro Cys Ser Ala Leu Pro Gly 195 200 205 Ala Pro Ser Pro Gly Asp Met Pro Gly Cys Val Leu His Cys Thr Ser 210 215 220 His Arg Gly Ala Ser Val Ser Leu Ala Val Lys 225 230 235 <210> 99 <211> 708 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(708) <400> 99 atg ctg tat ctg ctg gtg cct gga gag tca tct gcc ctg ggc ttc tgc 48 Met Leu Tyr Leu Leu Val Pro Gly Glu Ser Ser Ala Leu Gly Phe Cys 1 5 10 15 gtt ctg gtg tgt gca gtg ctg tat ctg ctg gtg cct gga gag tca tct 96 Val Leu Val Cys Ala Val Leu Tyr Leu Leu Val Pro Gly Glu Ser Ser 20 25 30 gcc ctg ggc ttc ccc gtc ctg gtg tgt gca atg ctg tat ctg ctg gtg 144 Ala Leu Gly Phe Pro Val Leu Val Cys Ala Met Leu Tyr Leu Leu Val 35 40 45 cct gga gag tca tct tcc ctc ggc ttc tgt gtc ctg gtg tgt gca gtg 192 Pro Gly Glu Ser Ser Ser Leu Gly Phe Cys Val Leu Val Cys Ala Val 50 55 60 ctg tat ctg ctg gtg cct gga gag tca tct gcc ctg ggc ttc tgc gtc 240 Leu Tyr Leu Leu Val Pro Gly Glu Ser Ser Ala Leu Gly Phe Cys Val 65 70 75 80 ctg gtg tgt gca atg ctg tat ctg ctg gtg cct gga gtc atc ttc cct 288 Leu Val Cys Ala Met Leu Tyr Leu Leu Val Pro Gly Val Ile Phe Pro 85 90 95 ggg ctt ctg cgt cct ggt gtg tgc agt gct gta tct gct ggt gtc tgg 336 Gly Leu Leu Arg Pro Gly Val Cys Ser Ala Val Ser Ala Gly Val Trp 100 105 110 aga gtc atc tgc cct ggg ctt ctg cgt tct ggt gtg tgc agt gct gta 384 Arg Val Ile Cys Pro Gly Leu Leu Arg Ser Gly Val Cys Ser Ala Val 115 120 125 tct gct ggt gcc tgg agt cat ctg ccc tgg gct tcc gcg tcc tgg tgt 432 Ser Ala Gly Ala Trp Ser His Leu Pro Trp Ala Ser Ala Ser Trp Cys 130 135 140 gtg cag tgc tgt atc tgc tgg tgc ctg gag tca tct gcc ctg ggc ttc 480 Val Gln Cys Cys Ile Cys Trp Cys Leu Glu Ser Ser Ala Leu Gly Phe 145 150 155 160 tgc gtc ctg gtg tct gca atg ctg tat ctg cgg gtg cct gga gag tca 528 Cys Val Leu Val Ser Ala Met Leu Tyr Leu Arg Val Pro Gly Glu Ser 165 170 175 tct gcc ctg ggc ttc cgc gtc ctg gtg tgt gca gtg ctg tat ctg ctg 576 Ser Ala Leu Gly Phe Arg Val Leu Val Cys Ala Val Leu Tyr Leu Leu 180 185 190 gtg cct gga gag tca tct gcc ctg ggc ttc tgc gtc ctg gtg tgt gca 624 Val Pro Gly Glu Ser Ser Ala Leu Gly Phe Cys Val Leu Val Cys Ala 195 200 205 gtg ctg tat ctg ctg gta att atg cag atg gga ttg ccc ttg agg gag 672 Val Leu Tyr Leu Leu Val Ile Met Gln Met Gly Leu Pro Leu Arg Glu 210 215 220 agt cac tgg caa atc ctg tct act acc att tat tga 708 Ser His Trp Gln Ile Leu Ser Thr Thr Ile Tyr 225 230 235 <210> 100 <211> 235 <212> PRT <213> Homo sapiens <400> 100 Met Leu Tyr Leu Leu Val Pro Gly Glu Ser Ser Ala Leu Gly Phe Cys 1 5 10 15 Val Leu Val Cys Ala Val Leu Tyr Leu Leu Val Pro Gly Glu Ser Ser 20 25 30 Ala Leu Gly Phe Pro Val Leu Val Cys Ala Met Leu Tyr Leu Leu Val 35 40 45 Pro Gly Glu Ser Ser Ser Leu Gly Phe Cys Val Leu Val Cys Ala Val 50 55 60 Leu Tyr Leu Leu Val Pro Gly Glu Ser Ser Ala Leu Gly Phe Cys Val 65 70 75 80 Leu Val Cys Ala Met Leu Tyr Leu Leu Val Pro Gly Val Ile Phe Pro 85 90 95 Gly Leu Leu Arg Pro Gly Val Cys Ser Ala Val Ser Ala Gly Val Trp 100 105 110 Arg Val Ile Cys Pro Gly Leu Leu Arg Ser Gly Val Cys Ser Ala Val 115 120 125 Ser Ala Gly Ala Trp Ser His Leu Pro Trp Ala Ser Ala Ser Trp Cys 130 135 140 V al Gln Cys Cys Ile Cys Trp Cys Leu Glu Ser Ser Ala Leu Gly Phe 145 150 155 160 Cys Val Leu Val Ser Ala Met Leu Tyr Leu Arg Val Pro Gly Glu Ser 165 170 175 Ser Ala Leu Gly Phe Arg Val Leu Val Cys Ala Val Leu Tyr Leu Leu 180 185 190 Val Pro Gly Glu Ser Ser Ala Leu Gly Phe Cys Val Leu Val Cys Ala 195 200 205 Val Leu Tyr Leu Leu Val Ile Met Gln Met Gly Leu Pro Leu Arg Glu 210 215 220 Ser His Trp Gln Ile Leu Ser Thr Thr Ile Tyr 225 230 235 <210> 101 <211> 801 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(801) <400> 101 atg gcc tcc cgg tat gtg gca gtg gga atg atc tta tca cag acc gtg 48 Met Ala Ser Arg Tyr Val Ala Val Gly Met Ile Leu Ser Gln Thr Val 1 5 10 15 gtg gga gtc ctg ggg agc ttc tct gtt ctt ctc cat tat ctc tcc ttt 96 Val Gly Val Leu Gly Ser Phe Ser Val Leu Leu His Tyr Leu Ser Phe 20 25 30 tac tgc act ggg tgc agg tta agg tcc aca gat ttg att gtt aag cac 144 Tyr Cys Thr Gly Cys Arg Leu Arg Ser Thr Asp Leu Ile Val Lys His 35 40 45 ctg att gta gcc aac ttc tta gct ctc cgc tgt aaa gga gtc ccc cag 192 Leu Ile Val Ala Asn Phe Leu Ala Leu Arg Cys Lys Gly Val Pro Gln 50 55 60 aca atg gca gct ttt ggg gtt aga tat ttt ctc aat gct ctt ggg tgc 240 Thr Met Ala Ala Phe Gly Val Arg Tyr Phe Leu Asn Ala Leu Gly Cys 65 70 75 80 aaa ctt gtt ttc tat ctc cat aga gtg ggc agg gga gtg tcc att ggc 288 Lys Leu Val Phe Tyr Leu His Arg Val Gly Arg Gly Val Ser Ile Gly 85 90 95 acc acc tgc ctc ttg agt gtc ttc cag gtg atc acg gtc agc tcc agg 336 Thr Thr Cys Leu Leu Ser Val Phe Gln Val Ile Thr Val Ser Ser Arg 100 105 110 a aa tcc agg tgg gca aaa ctt aaa gag aaa gcc ccc aag cat gtt ggc 384 Lys Ser Arg Trp Ala Lys Leu Lys Glu Lys Ala Pro Lys His Val Gly 115 120 125 ttt tct gtt ctc ctg tgc tgg atc gtg tgc atg ttg gta aac atc atc 432 Phe Ser Val Leu Leu Cys Trp Ile Val Cys Met Leu Val Asn Ile Ile 130 135 140 ttt ccc atg tat gtg act ggc aaa tgg aac tac aca aac atc aca gtg 480 Phe Pro Met Tyr Val Thr Gly Lys Trp Asn Tyr Thr Asn Ile Thr Val 145 150 155 160 aac gag gat ttg gga tac tgt tct ggg gga ggc aac aac aaa atc gca 528 Asn Glu Asp Leu Gly Tyr Cys Ser Gly Gly Gly Asn Asn Lys Ile Ala 165 170 175 cag aca ctg cgt gca atg ttg tta tca ttc cct gat gtg ttg tgt ctg 576 Gln Thr Leu Arg Ala Met Leu Leu Ser Phe Pro Asp Val Leu Cys Leu 180 185 190 ggg ctc atg ctc tgg gtc agc agc tcc atg gtt tgc ata ctg cac agg 624 Gly Leu Met Leu Trp Val Ser Ser Ser Met Val Cys Ile Leu His Arg 195 200 205 cac aag cag cgg gtc cag cac att gat agg agc gat ctc tcc ccc aga 672 His Lys Gln Arg Val Gln His Ile Asp Arg Ser Asp Leu Ser Pro Arg 210 215 220 gcc tcc cca gag aac aga gct acg cag agc atc ttc atc ctg gtg agc 720 Ala Ser Pro Glu Asn Arg Ala Thr Gln Ser Ile Phe Ile Leu Val Ser 225 230 235 240 acc ttg tgt ctt ctt aca ctc tct cct gcc ttt tcc aag ttt gta tgg 768 Thr Leu Cys Leu Leu Thr Leu Ser Pro Ala Phe Ser Lys Phe Val Trp 245 250 255 ctc ttt tgg ata atc cca ata gtt tac tgg tga 801 Leu Phe Trp Ile Ile Pro Ile Val Tyr Trp 260 265 <210> 102 <211> 266 <212> PRT <213> Homo sapiens <400> 102 Met Ala Ser Arg Tyr Val Ala Val Gly Met Ile Leu Ser Gln Thr Val 1 5 10 15 Val Gly Val Leu Gly Ser Phe Ser Val Leu Leu His Tyr Leu Ser Phe 20 25 30 Tyr Cys Thr Gly Cys Arg Leu Arg Ser Thr Asp Leu Ile Val Lys His 35 40 45 Leu Ile Val Ala Asn Phe Leu Ala Leu Arg Cys Lys Gly Val Pro Gln 50 55 60 Thr Met Ala Ala Phe Gly Val Arg Tyr Phe Leu Asn Ala Leu Gly Cys 65 70 75 80 Lys Leu Val Phe Tyr Leu His Arg Val Gly Arg Gly Val Ser Ile Gly 85 90 95 Thr Thr Cys Leu Leu Ser Val Phe Gln Val Ile Thr Val Ser Ser Arg 100 105 110 Lys Ser Arg Trp Ala Lys Leu Lys Glu Lys Ala Pro Lys His Val Gly 115 120 125 Phe Ser Val Leu Leu Cys Trp Ile Val Cys Met Leu Val Asn Ile Ile 130 135 140 Phe Pro Met Tyr Val Thr Gly Lys Trp Asn Tyr Thr Asn Ile Thr Val 145 150 155 160 Asn Glu Asp Leu Gly Tyr Cys Ser Gly Gly Gly Asn Asn Lys Ile Ala 165 170 175 Gln Thr Leu Arg Ala Met Leu Leu Ser Phe Pro Asp Val Leu Cys Leu 180 185 190 Gly Leu Met Leu Trp Val Ser Ser Ser Met Val Cys Ile Leu His Arg 195 200 205 His Lys Gln Arg Val Gln His Ile Asp Arg Ser Asp Leu Ser Pro Arg 210 215 220 Ala Ser Pro Glu Asn Arg Ala Thr Gln Ser Ile Phe Ile Leu Val Ser 225 230 235 240 Thr Leu Cys Leu Leu Thr Leu Ser Pro Ala Phe Ser Lys Phe Val Trp 245 250 255 Leu Phe Trp Ile Ile Pro Ile Val Tyr Trp 260 265 <210> 103 <211> 1029 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1029) <400> 103 atg atg tcc ttc tgt gta att ttt gaa agt tgt aag gct ttc ctt ttg 48 Met Met Ser Phe Cys Val Ile Phe Glu Ser Cys Lys Ala Phe Leu Leu 1 5 10 15 ata ttt cta aat aca aca cat gta gaa ttt att ttt atg aat gat gag 96 Ile Phe Leu Asn Thr Thr His Val Glu Phe Ile Phe Met Asn Asp Glu 20 25 30 gta agg tca agg cat att ttt tgn nnn nnn nnn nnn nnn nnn nnn nnn 144 Val Arg Ser Arg His Ile Phe Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 35 40 45 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 192 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 50 55 60 nnn nnn nnn nnn nnn nnn nnn nnn nnn ttt cat ggc tgg att tcc atg 240 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Phe His Gly Trp Ile Ser Met 65 70 75 80 ccc ttt tgc tgt att tac ttg atg cct ctg ctg agc aat gct aca att 288 Pro Phe Cys Cys Ile Tyr Leu Met Pro Leu Leu Ser Asn Ala Thr Ile 85 90 95 cta ctg aca atc tgg tct gat cgt act ctt cgg gac cct atg ttc tac 336 Leu Leu Thr Ile Trp Ser Asp Arg Thr Leu Arg Asp Pro Met Phe Tyr 100 105 110 ttt cta gcc atc tta tca gcc ata gac cta gcc ctc tca aca tcc tca 384 Phe Leu Ala Ile Leu Ser Ala Ile Asp Leu Ala Leu Ser Thr Ser Ser 115 120 125 gtg cct cgt atg ttg ggt atc ttc tgg ttt gat gca cat aaa att ggc 432 Val Pro Arg Met Leu Gly Ile Phe Trp Phe Asp Ala His Lys Ile Gly 130 135 140 ttt gga gcc tgg gta gcc cag atg ttt ctg ata cac act ttc aca gga 480 Phe Gly Ala Trp Val Ala Gln Met Phe Leu Ile His Thr Phe Thr Gly 145 150 155 160 atg gag tcc act gtg ctg ctg gca atg gcc ttt gac cgc tat gtg gcc 528 Met Glu Ser Thr Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala 165 170 175 atc tgt aca tca ctc cac tat acc tct act ctg aca ccc cga gta ttg 576 Ile Cys Thr Ser Leu His Tyr Thr Ser Thr Leu Thr Pro Arg Val Leu 180 185 190 gca ggc att ggt gtg agc att ata atg cgc cca gtc ctg ctc atg ttg 624 Ala Gly Ile Gly Val Ser Ile Ile Met Arg Pro Val Leu Leu Met Leu 195 200 205 ccc att ctc tac cta acc cat cgt ctg ccc ttc tgt gag gct cgg att 672 Pro Ile Leu Tyr Leu Thr His Arg Leu Pro Phe Cys Glu Ala Arg Ile 210 215 220 att gcc cac tcc tac tgt gag cac atg ggt att gct aag ttg gcc tgt 720 Ile Ala His Ser Tyr Cys Glu His Met Gly Ile Ala Lys Leu Ala Cys 225 230 235 240 gc t agc att cac atc aat gct att tat ggg ctt ttt gtg gct tct tat 768 Ala Ser Ile His Ile Asn Ala Ile Tyr Gly Leu Phe Val Ala Ser Tyr 245 250 255 ttt gga tgt cgc act tgt tgg aat ctc cta tac cta cat tct ccg agc 816 Phe Gly Cys Arg Thr Cys Trp Asn Leu Leu Tyr Leu His Ser Pro Ser 260 265 270 tgt ttt cca cct ccc atc tca aga cgc tcg tca caa agc act gag aac 864 Cys Phe Pro Pro Pro Ile Ser Arg Arg Ser Ser Gln Ser Thr Glu Asn 275 280 285 gtg tgg ctc aca tgt tgg ggt cat gtg tgt ttt cta tac acc ctc cct 912 Val Trp Leu Thr Cys Trp Gly His Val Cys Phe Leu Tyr Thr Leu Pro 290 295 300 ctt ctc ctt cct cac cta ccg att tcg caa aaa aaa ttc ccc gtt atg 960 Leu Leu Leu Pro His Leu Pro Ile Ser Gln Lys Lys Phe Pro Val Met 305 310 315 320 tcc aca ttc ttg ttg cca acc tct atg tgg tca ttc cac ctg ccc tca 1008 Ser Thr Phe Leu Leu Pro Thr Ser Met Trp Ser Phe His Leu Pro Ser 325 330 335 atc cta tta tct atg gtg tga 1029 Ile Leu Leu Ser Met Val 340 <210> 104 <211> 342 <212> PRT <213> Homo sapiens <400> 104 Met Met Ser Phe Cys Val Ile Phe Glu Ser Cys Lys Ala Phe Leu Leu 1 5 10 15 Ile Phe Leu Asn Thr Thr His Val Glu Phe Ile Phe Met Asn Asp Glu 20 25 30 Val Arg Ser Arg His Ile Phe Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 35 40 45 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 50 55 60 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Phe His Gly Trp Ile Ser Met 65 70 75 80 Pro Phe Cys Cys Ile Tyr Leu Met Pro Leu Leu Ser Asn Ala Thr Ile 85 90 95 Leu Leu Thr Ile Trp Ser Asp Arg Thr Leu Arg Asp Pro Met Phe Tyr 100 105 110 Phe Leu Ala Ile Leu Ser Ala Ile Asp Leu Ala Leu Ser Thr Ser Ser 115 120 125 Val Pro Arg Met Leu Gly Ile Phe Trp Phe Asp Ala His Lys Ile Gly 130 135 140 Phe Gly Ala Trp Val Ala Gln Met Phe Leu Ile His Thr Phe Thr Gly 145 150 155 160 Met Glu Ser Thr Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala 165 170 175 Ile Cys Thr Ser Leu His Tyr Thr Ser Thr Leu Thr Pro Arg Val Leu 180 185 190 Ala Gly Ile Gly Val Ser Ile Ile Met Arg Pro Val Leu Leu Met Leu 195 200 205 Pro Ile Leu Tyr Leu Thr His Arg Leu Pro Phe Cys Glu Ala Arg Ile 210 215 220 Ile Ala His Ser Tyr Cys Glu His Met Gly Ile Ala Lys Leu Ala Cys 225 230 235 240 Ala Ser Ile His Ile Asn Ala Ile Tyr Gly Leu Phe Val Ala Ser Tyr 245 250 255 Phe Gly Cys Arg Thr Cys Trp Asn Leu Leu Tyr Leu His Ser Pro Ser 260 265 270 Cys Phe Pro Pro Pro Ile Ser Arg Arg Ser Ser Gln Ser Thr Glu Asn 275 280 285 Val Trp Leu Thr Cys Trp Gly His Val Cys Phe Leu Tyr Thr Leu Pro 290 295 300 Leu Leu Leu Pro His Leu Pro Ile Ser Gln Lys Lys Phe Pro Val Met 305 310 315 320 Ser Thr Phe Leu Leu Pro Thr Ser Met Trp Ser Phe His Leu Pro Ser 325 330 335 Ile Leu Leu Ser Met Val 340 <210> 105 <211> 795 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(795) <400> 105 atg gcc atg tat tct tcc tct caa tgc tgn cng tca tgg aca tcn tgc 48 Met Ala Met Tyr Ser Ser Ser Gln Cys Xaa Xaa Ser Trp Thr Xaa Cys 1 5 10 15 tgt cta cca cac tgt gcc caa ggc cnt agc atc ttt tgg ctt caa gca 96 Cys Leu Pro His Cys Ala Gln Gly Xaa Ser Ile Phe Trp Leu Gln Ala 20 25 30 cat aac att gct ttt gat gcc tgt gtc acc caa ggc ttc ttt gtc cat 144 His Asn Ile Ala Phe Asp Ala Cys Val Thr Gln Gly Phe Phe Val His 35 40 45 atg atg ttt gtg ggg gag tca gct atc ctg tta gcc atg gcc ttt gat 192 Met Met Phe Val Gly Glu Ser Ala Ile Leu Leu Ala Met Ala Phe Asp 50 55 60 cgc ttt gtg gcc att tgt gcc cca ctg aga tat aca aca gtg cta aca 240 Arg Phe Val Ala Ile Cys Ala Pro Leu Arg Tyr Thr Thr Val Leu Thr 65 70 75 80 tgg cct gtt gtg ggg agg att gct ctg gcc gtc atc acc cga agc ttc 288 Trp Pro Val Val Gly Arg Ile Ala Leu Ala Val Ile Thr Arg Ser Phe 85 90 95 tgc atc atc ttc cca gtc ata ttc ttg ctg aag cgg ctg ccc ttc tgc 336 Cys Ile Ile Phe Pro Val Ile Phe Leu Leu Lys Arg Leu Pro Phe Cys 100 105 110 cta acc aac att gtt cct cac tcc tac tgt gag cat att gga gtg gct 384 Leu Thr Asn Ile Val Pro His Ser Tyr Cys Glu His Ile Gly Val Ala 115 120 125 cgt tta gcc tgt gct gac atc act gtt aac att tgg tat ggc ttc tca 432 Arg Leu Ala Cys Ala Asp Ile Thr Val Asn Ile Trp Tyr Gly Phe Ser 130 135 140 gtg ccc att gtc atg gtc atc ttg gat gtt atc ctc atc gct gtg tct 480 Val Pro Ile Val Met Val Ile Leu Asp Val Ile Leu Ile Ala Val Ser 145 150 155 160 tac tca ctg atc ctc cga gca gtg ttt cgt ttg ccc tcc cag gat gct 528 Tyr Ser Leu Ile Leu Arg Ala Val Phe Arg Leu Pro Ser Gln Asp Ala 165 170 175 cgg cac aag gcc ctc agc act tgt ggc tcc cac ctc tgt gtc atc ctt 576 Arg His Lys Ala Leu Ser Thr Cys Gly Ser His Leu Cys Val Ile Leu 180 185 190 atg ttt tat gtt cca tcc ttc ttt acc tta ttg acc cat cat ttt ggg 624 Met Phe Tyr Val Pro Ser Phe Phe Thr Leu Leu Thr His His Phe Gly 195 200 205 cgt aat att cct caa cat gtc cat atc ttg ctg gcc aat ctt tat gtg 672 Arg Asn Ile Pro Gln His Val His Ile Leu Leu Ala Asn Leu Tyr Val 210 215 220 gca gtg cca cca atg ctg aac ccc att gtc tat ggt gtg aag act aag 720 Ala Val Pro Pro Met Leu Asn Pro Ile Val Tyr Gly Val Lys Thr Lys 225 230 235 240 cag ata cgt gag ggt gta gcc cac cgg ttc ttt gac atc aag act tgg 768 Gln Ile Arg Glu Gly Val Ala His Arg Phe Phe Asp Ile Lys Thr Trp 245 250 255 tgc tgt acc tcc cct ctg ggc tca tga 795 Cys Cys Thr Ser Pro Leu Gly Ser 260 265 <210> 106 <211> 264 <212> PRT <213> Homo sapiens <400> 106 Met Ala Met Tyr Ser Ser Ser Gln Cys Xaa Xaa Ser Trp Thr Xaa Cys 1 5 10 15 Cys Leu Pro His Cys Ala Gln Gly Xaa Ser Ile Phe Trp Leu Gln Ala 20 25 30 His Asn Ile Ala Phe Asp Ala Cys Val Thr Gln Gly Phe Phe Val His 35 40 45 Met Met Phe Val Gly Glu Ser Ala Ile Leu Leu Ala Met Ala Phe Asp 50 55 60 Arg Phe Val Ala Ile Cys Ala Pro Leu Arg Tyr Thr Thr Val Leu Thr 65 70 75 80 Trp Pro Val Val Gly Arg Ile Ala Leu Ala Val Ile Thr Arg Ser Phe 85 90 95 Cys Ile Ile Phe Pro Val Ile Phe Leu Leu Lys Arg Leu Pro Phe Cys 100 105 110 Leu Thr Asn Ile Val Pro His Ser Tyr Cys Glu His Ile Gly Val Ala 115 120 125 Arg Leu Ala Cys Ala Asp Ile Thr Val Asn Ile Trp Tyr Gly Phe Ser 130 135 140 Val Pro Ile Val Met Val Ile Leu Asp Val Ile Leu Ile Ala Val Ser 145 150 155 160 Tyr Ser Leu Ile Leu Arg Ala Val Phe Arg Leu Pro Ser Gln Asp Ala 165 170 175 Arg His Lys Ala Leu Ser Thr Cys Gly Ser His Leu Cys Val Ile Leu 180 185 190 Met Phe Tyr Val Pro Ser Phe Phe Thr Leu Leu Thr His His Phe Gly 195 200 205 Arg Asn Ile Pro Gln His Val His Ile Leu Leu Ala Asn Leu Tyr Val 210 215 220 Ala Val Pro Pro Met Leu Asn Pro Ile Val Tyr Gly Val Lys Thr Lys 225 230 235 240 Gln Ile Arg Glu Gly Val Ala His Arg Phe Phe Asp Ile Lys Thr Trp 245 250 255 Cys Cys Thr Ser Pro Leu Gly Ser 260 <210> 107 <211> 762 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(762) <400> 107 atg tat ttc ttc ctt aat tac ctc gca ctc tca gat ctt tgc tac ata 48 Met Tyr Phe Phe Leu Asn Tyr Leu Ala Leu Ser Asp Leu Cys Tyr Ile 1 5 10 15 tcc act gtg gcc ccc aag cta atg att gac cta cta aca gaa agg aag 96 Ser Thr Val Ala Pro Lys Leu Met Ile Asp Leu Leu Thr Glu Arg Lys 20 25 30 atc gtt tcc tat aat aac tgc atg ata cag cta ttt atc act cac ttc 144 Ile Val Ser Tyr Asn Asn Cys Met Ile Gln Leu Phe Ile Thr His Phe 35 40 45 ctt gga gac att gag atc ttc ata ctc aaa gca atg gcc tat gac cac 192 Leu Gly Asp Ile Glu Ile Phe Ile Leu Lys Ala Met Ala Tyr Asp His 50 55 60 tac ata gcc atc tgc aag cac ctg cac tac acc atc atc acg acc aag 240 Tyr Ile Ala Ile Cys Lys His Leu His Tyr Thr Ile Ile Thr Thr Lys 65 70 75 80 caa agc tgt aac acc atc atc ata gct tgt tgt act ggg gga ttt ata 288 Gln Ser Cys Asn Thr Ile Ile Ile Ala Cys Cys Thr Gly Gly Phe Ile 85 90 95 cac tct gcc agt cag ttt ctt ctt acc atc ttc tta ccg ttc tgt ggt 336 His Ser Ala Ser Gln Phe Leu Leu Thr Ile Phe Leu Pro Phe Cys Gly 100 105 110 ctt aat gag ata gat cag tac ttc tgc tat gtg tat cct ctg ctg aag 384 Leu Asn Glu Ile Asp Gln Tyr Phe Cys Tyr Val Tyr Pro Leu Leu Lys 115 120 125 ttg gct cgc att gat ata tac aga att ggt ttc ttg gta att gtt aat 432 Leu Ala Arg Ile Asp Ile Tyr Arg Ile Gly Phe Leu Val Ile Val Asn 130 135 140 tca ggc ctg att tct ttg ttg gct ttt gtg att ttg atg gtg tct tat 480 Ser Gly Leu Ile Ser Leu Leu Ala Phe Val Ile Leu Met Val Ser Tyr 145 150 155 160 tat ttg ata tta tcc acc atc agg gtt tac tct gct gag agt cat acc 528 Tyr Leu Ile Leu Ser Thr Ile Arg Val Tyr Ser Ala Glu Ser His Thr 165 170 175 aaa gct ctt tca acc tgt agc tct cac ata ata gtt gtg gtc cta ttc 576 Lys Ala Leu Ser Thr Cys Ser Ser His Ile Ile Val Val Val Leu Phe 180 185 190 ttt gtg cct gcc ctc ttc att tac atc aga cca gcc ata act ttt cca 624 Phe Val Pro Ala Leu Phe Ile Tyr Ile Arg Pro Ala Ile Thr Phe Pro 195 200 205 gaa gat aaa gtg ttt gtt ctc ttc tgt gcc atc att gct ccc atg ttc 672 Glu Asp Lys Val Phe Val Leu Phe Cys Ala Ile Ile Ala Pro Met Phe 210 215 220 agt ctt ctt atc tac atg ctg aga aag gtg gag atg aag aac gct gta 720 Ser Leu Leu Ile Tyr Met Leu Arg Lys Val Glu Met Lys Asn Ala Val 225 230 235 240 agg aaa atg tgg tgt cat caa ttg ctt ctg gca agg aag taa 762 Arg Lys Met Trp Cys His Gln Leu Leu Leu Ala Arg Lys 245 250 <210> 108 <211> 253 <212> PRT <213> Homo sapiens <400> 108 Met Tyr Phe Phe Leu Asn Tyr Leu Ala Leu Ser Asp Leu Cys Tyr Ile 1 5 10 15 Ser Thr Val Ala Pro Lys Leu Met Ile Asp Leu Leu Thr Glu Arg Lys 20 25 30 Ile Val Ser Tyr Asn Asn Cys Met Ile Gln Leu Phe Ile Thr His Phe 35 40 45 Leu Gly Asp Ile Glu Ile Phe Ile Leu Lys Ala Met Ala Tyr Asp His 50 55 60 Tyr Ile Ala Ile Cys Lys His Leu His Tyr Thr Ile Ile Thr Thr Lys 65 70 75 80 Gln Ser Cys Asn Thr Ile Ile Ile Ala Cys Cys Thr Gly Gly Phe Ile 85 90 95 His Ser Ala Ser Gln Phe Leu Leu Thr Ile Phe Leu Pro Phe Cys Gly 100 105 110 Leu Asn Glu Ile Asp Gln Tyr Phe Cys Tyr Val Tyr Pro Leu Leu Lys 115 120 125 Leu Ala Arg Ile Asp Ile Tyr Arg Ile Gly Phe Leu Val Ile Val Asn 130 135 140 Ser Gly Leu Ile Ser Leu Leu Ala Phe Val Ile Leu Met Val Ser Tyr 145 150 155 160 Tyr Leu Ile Leu Ser Thr Ile Arg Val Tyr Ser Ala Glu Ser His Thr 165 170 175 Lys Ala Leu Ser Thr Cys Ser Ser His Ile Ile Val Val Val Leu Phe 180 185 190 Phe Val Pro Ala Leu Phe Ile Tyr Ile Arg Pro Ala Ile Thr Phe Pro 195 200 205 Glu Asp Lys Val Phe Val Leu Phe Cys Ala Ile Ile Ala Pro Met Phe 210 215 220 Ser Leu Leu Ile Tyr Met Leu Arg Lys Val Glu Met Lys Asn Ala Val 225 230 235 240 Arg Lys Met Trp Cys His Gln Leu Leu Leu Ala Arg Lys 245 250 <210> 109 <211> 675 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(675) <400> 109 atg ttc tcc tgc aac acc agc act tct ggt cag tct acc ttc ctc ctc 48 Met Phe Ser Cys Asn Thr Ser Thr Ser Gly Gln Ser Thr Phe Leu Leu 1 5 10 15 act ggt ttt cca ggc ctg gaa gcc tct cat cat tgg gtt tcc atc ccc 96 Thr Gly Phe Pro Gly Leu Glu Ala Ser His His Trp Val Ser Ile Pro 20 25 30 atc aac ctc ttc tgt gtg gtt tcc atc ctg ggt aat aat atc atc ctc 144 Ile Asn Leu Phe Cys Val Val Ser Ile Leu Gly Asn Asn Ile Ile Leu 35 40 45 ttc ctg atc cac aca gat cca gcc tta cat gaa ccc atg tat atc ttc 192 Phe Leu Ile His Thr Asp Pro Ala Leu His Glu Pro Met Tyr Ile Phe 50 55 60 ctg tcc atg ttg gca gcc tct gat ctg ggc ctc tgt gcc tct acc ttc 240 Leu Ser Met Leu Ala Ala Ser Asp Leu Gly Leu Cys Ala Ser Thr Phe 65 70 75 80 ccc act atg gtg cgt ctc ttc tgg ctg gga gct cgt gag ctg ccc ttt 288 Pro Thr Met Val Arg Leu Phe Trp Leu Gly Ala Arg Glu Leu Pro Phe 85 90 95 gat ctc tgt gca gca cag atg ttc ttc atc cat acc ttc acc tat gtg 336 Asp Leu Cys Ala Ala Gln Met Phe Phe Ile His Thr Phe Thr Tyr Val 100 105 110 gag tcc ggt gta ctg ctg gcc atg gcc ttc gat cgc ttt att gcc atc 384 Glu Ser Gly Val Leu Leu Ala Met Ala Phe Asp Arg Phe Ile Ala Ile 115 120 125 cgg gac cct ctg cat tat gcc ata atc att acc tgc tca gtc aca gcc 432 Arg Asp Pro Leu His Tyr Ala Ile Ile Ile Thr Cys Ser Val Thr Ala 130 135 140 gag gtg gga act gcc att ctg gtg agg gct gtt ctg ctc aac ctc ccg 480 Glu Val Gly Thr Ala Ile Leu Val Arg Ala Val Leu Leu Asn Leu Pro 145 150 155 160 gga cct atc ctc ctg cag cag ctg ctc ttt ccc aag atc agc gct ctc 528 Gly Pro Ile Leu Leu Gln Gln Leu Leu Phe Pro Lys Ile Ser Ala Leu 165 170 175 tgt cac tgc tac tgc ctg cac tgt gac ctt gtg ggg ttg gcc tgc tca 576 Cys His Cys Tyr Cys Leu His Cys Asp Leu Val Gly Leu Ala Cys Ser 180 185 190 gac acc cag atc aat agc ctg gtt ggc ctg gtt tcc atc ctc ttc tca 624 Asp Thr Gln Ile Asn Ser Leu Val Gly Leu Val Ser Ile Leu Phe Ser 195 200 205 ctg tgc ctt gac tcc ttc ctc atc atg ctt tca tat gcc ctg atc cta 672 Leu Cys Leu Asp Ser Phe Leu Ile Met Leu Ser Tyr Ala Leu Ile Leu 210 215 220 tga 675 225 <210> 110 <211> 224 <212> PRT <213> Homo sapiens <400> 110 Met Phe Ser Cys Asn Thr Ser Thr Ser Gly Gln Ser Thr Phe Leu Leu 1 5 10 15 Thr Gly Phe Pro Gly Leu Glu Ala Ser His His Trp Val Ser Ile Pro 20 25 30 Ile Asn Leu Phe Cys Val Val Ser Ile Leu Gly Asn Asn Ile Ile Leu 35 40 45 Phe Leu Ile His Thr Asp Pro Ala Leu His Glu Pro Met Tyr Ile Phe 50 55 60 Leu Ser Met Leu Ala Ala Ser Asp Leu Gly Leu Cys Ala Ser Thr Phe 65 70 75 80 Pro Thr Met Val Arg Leu Phe Trp Leu Gly Ala Arg Glu Leu Pro Phe 85 90 95 Asp Leu Cys Ala Ala Gln Met Phe Phe Ile His Thr Phe Thr Tyr Val 100 105 110 Glu Ser Gly Val Leu Leu Ala Met Ala Phe Asp Arg Phe Ile Ala Ile 115 120 125 Arg Asp Pro Leu His Tyr Ala Ile Ile Ile Thr Cys Ser Val Thr Ala 130 135 140 Glu Val Gly Thr Ala Ile Leu Val Arg Ala Val Leu Leu Asn Leu Pro 145 150 155 160 Gly Pro Ile Leu Leu Gln Gln Leu Leu Phe Pro Lys Ile Ser Ala Leu 165 170 175 Cys His Cys Tyr Cys Leu His Cys Asp Leu Val Gly Leu Ala Cys Ser 180 185 190 Asp Thr Gln Ile Asn Ser Leu Val Gly Leu Val Ser Ile Leu Phe Ser 195 200 205 Leu Cys Leu Asp Ser Phe Leu Ile Met Leu Ser Tyr Ala Leu Ile Leu 210 215 220 <210> 111 <211> 957 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(957) <400> 111 atg cct act gta aac cac agt ggc act agc cac aca gtc ttc cac ttg 48 Met Pro Thr Val Asn His Ser Gly Thr Ser His Thr Val Phe His Leu 1 5 10 15 ctg ggc atc cct ggc cta cag gac cag cac atg tgg att tct atc cca 96 Leu Gly Ile Pro Gly Leu Gln Asp Gln His Met Trp Ile Ser Ile Pro 20 25 30 ttc ttc att tcc tat gtc acc gcc ctt ctt ggg aac agc ctg ctc atc 144 Phe Phe Ile Ser Tyr Val Thr Ala Leu Leu Gly Asn Ser Leu Leu Ile 35 40 45 ttc att atc ctc aca aag cgc agc ctc cat gaa ccc atg tac ctc ttc 192 Phe Ile Ile Leu Thr Lys Arg Ser Leu His Glu Pro Met Tyr Leu Phe 50 55 60 ctc tgc atg ctg gct gga gca gac att gtc ctc tcc acg tgc acc att 240 Leu Cys Met Leu Ala Gly Ala Asp Ile Val Leu Ser Thr Cys Thr Ile 65 70 75 80 cct cag gcc tta gct atc ttc tgg ttc cgt gct ggg gac atc tcc ctg 288 Pro Gln Ala Leu Ala Ile Phe Trp Phe Arg Ala Gly Asp Ile Ser Leu 85 90 95 gat cgt tgc atc act cag ctc ttc ttc atc cat tcc acc ttc atc tct 336 Asp Arg Cys Ile Thr Gln Leu Phe Phe Ile His Ser Thr Phe Ile Ser 100 105 110 gag tca ggg atc ttg ctg gtg atg gcc ttt gac cac tat att gcc ata 384 Glu Ser Gly Ile Leu Leu Val Met Ala Phe Asp His Tyr Ile Ala Ile 115 120 125 tgc tac cca ctg agg tac acc acc att ctt aca aat gct ctg atc aag 432 Cys Tyr Pro Leu Arg Tyr Thr Thr Ile Leu Thr Asn Ala Leu Ile Lys 130 135 140 aaa att tgt gtg act gtc tct ctg aga agt tat ggt aca att ttc cct 480 Lys Ile Cys Val Thr Val Ser Leu Arg Ser Tyr Gly Thr Ile Phe Pro 145 150 155 160 atc ata ttt ctt tta aaa aga ttg act ttc tgc cag aat aat att att 528 Ile Ile Phe Leu Leu Lys Arg Leu Thr Phe Cys Gln Asn Asn Ile Ile 165 170 175 cca cac acc ttt tgt gaa cac att ggc cta gcc aaa tat gca tgt aat 576 Pro His Thr Phe Cys Glu His Ile Gly Leu Ala Lys Tyr Ala Cys Asn 180 185 190 gac att cga ata aac att tgg tat ggg ttt tcc att cta atg tcg acg 624 Asp Ile Arg Ile Asn Ile Trp Tyr Gly Phe Ser Ile Leu Met Ser Thr 195 200 205 gtg gtc tta gat gtt gta cta att ttt att tcc tat atg ctg att ctc 672 Val Val Leu Asp Val Val Leu Ile Phe Ile Ser Tyr Met Leu Ile Leu 210 215 220 cat gct gtc ttc cac atg cct tct cca gat gct tgc cac aaa gct ctc 720 His Ala Val Phe His Met Pro Ser Pro Asp Ala Cys His Lys Ala Leu 225 230 235 240 aac aca ttt ggc tcc cat gtc tgc atc atc atc ctc ttt tat ggg tct 768 Asn Thr Phe Gly Ser His Val Cys Ile Ile Ile Leu Phe Tyr Gly Ser 245 250 255 ggc atc ttc aca atc ctt acc cag agg ttt gga cgc cac att cca cct 816 Gly Ile Phe Thr Ile Leu Thr Gln Arg Phe Gly Arg His Ile Pro Pro 260 265 270 tgt atc cac atc ccg ttg gct aat gtc tgc att ctg gct cca cct atg 864 Cys Ile His Ile Pro Leu Ala Asn Val Cys Ile Leu Ala Pro Pro Met 275 280 285 ctg aat ccc att att tat ggg atc aaa acc aag caa atc cag gaa cag 912 Leu Asn Pro Ile Ile Tyr Gly Ile Lys Thr Lys Gln Ile Gln Glu Gln 290 295 300 gtg gtt cag ttt ttg ttt ata aaa cag aaa ata act ttg gtt taa 957 Val Val Gln Phe Leu Phe Ile Lys Gln Lys Ile Thr Leu Val 305 310 315 <210> 112 <211> 318 <212> PRT <213> Homo sapiens <400> 112 Met Pro Thr Val Asn His Ser Gly Thr Ser His Thr Val Phe His Leu 1 5 10 15 Leu Gly Ile Pro Gly Leu Gln Asp Gln His Met Trp Ile Ser Ile Pro 20 25 30 Phe Phe Ile Ser Tyr Val Thr Ala Leu Leu Gly Asn Ser Leu Leu Ile 35 40 45 Phe Ile Ile Leu Thr Lys Arg Ser Leu His Glu Pro Met Tyr Leu Phe 50 55 60 Leu Cys Met Leu Ala Gly Ala Asp Ile Val Leu Ser Thr Cys Thr Ile 65 70 75 80 Pro Gln Ala Leu Ala Ile Phe Trp Phe Arg Ala Gly Asp Ile Ser Leu 85 90 95 Asp Arg Cys Ile Thr Gln Leu Phe Phe Ile His Ser Thr Phe Ile Ser 100 105 110 Glu Ser Gly Ile Leu Leu Val Met Ala Phe Asp His Tyr Ile Ala Ile 115 120 125 Cys Tyr Pro Leu Arg Tyr Thr Thr Ile Leu Thr Asn Ala Leu Ile Lys 130 135 140 Lys Ile Cys Val Thr Val Ser Leu Arg Ser Tyr Gly Thr Ile Phe Pro 145 150 155 160 Ile Ile Phe Leu Leu Lys Arg Leu Thr Phe Cys Gln Asn Asn Ile Ile 165 170 175 Pro His Thr Phe Cys Glu His Ile Gly Leu Ala Lys Tyr Ala Cys Asn 180 185 190 Asp Ile Arg Ile Asn Ile Trp Tyr Gly Phe Ser Ile Leu Met Ser Thr 195 200 205 Val Val Leu Asp Val Val Leu Ile Phe Ile Ser Tyr Met Leu Ile Leu 210 215 220 His Ala Val Phe His Met Pro Ser Pro Asp Ala Cys His Lys Ala Leu 225 230 235 240 Asn Thr Phe Gly Ser His Val Cys Ile Ile Ile Leu Phe Tyr Gly Ser 245 250 255 Gly Ile Phe Thr Ile Leu Thr Gln Arg Phe Gly Arg His Ile Pro Pro 260 265 270 Cys Ile His Ile Pro Leu Ala Asn Val Cys Ile Leu Ala Pro Pro Met 275 280 285 Leu Asn Pro Ile Ile Tyr Gly Ile Lys Thr Lys Gln Ile Gln Glu Gln 290 295 300 Val Val Gln Phe Leu Phe Ile Lys Gln Lys Ile Thr Leu Val 305 310 315 <210> 113 <211> 951 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(951) <400> 113 atg aag ata gca aac aac aca gta gtg aca gaa ttt atc ctc ctt ggt 48 Met Lys Ile Ala Asn Asn Thr Val Val Thr Glu Phe Ile Leu Leu Gly 1 5 10 15 ctg act cag tct caa gat att cag ctc ttg gtc ttt gtg ctg atc tta 96 Leu Thr Gln Ser Gln Asp Ile Gln Leu Leu Val Phe Val Leu Ile Leu 20 25 30 att ttc tac ctt atc atc ctc cct gga aat ttt ctc att att ttc acc 144 Ile Phe Tyr Leu Ile Ile Leu Pro Gly Asn Phe Leu Ile Ile Phe Thr 35 40 45 ata agg tca gac cct ggg ctc aca gcc ccc ctc tat ttc ttt ctg ggc 192 Ile Arg Ser Asp Pro Gly Leu Thr Ala Pro Leu Tyr Phe Phe Leu Gly 50 55 60 aac ttg gcc ttc ctg gat gca tcc tac tcc ttc att gtg gct ccc agg 240 Asn Leu Ala Phe Leu Asp Ala Ser Tyr Ser Phe Ile Val Ala Pro Arg 65 70 75 80 atg ttg gtg gac ttc ttc tct gag aag aag gta atc tcc tac aga ggc 288 Met Leu Val Asp Phe Phe Ser Glu Lys Lys Val Ile Ser Tyr Arg Gly 85 90 95 t gc atc act cag ctc ttt ttc ttg cac ttc ctt gga gga ggg gag gga 336 Cys Ile Thr Gln Leu Phe Phe Leu His Phe Leu Gly Gly Gly Glu Gly 100 105 110 tta ctc ctt gtt gtg atg gcc ttt gac cgc tac atc gcc atc tgc cgg 384 Leu Leu Leu Val Val Met Ala Phe Asp Arg Tyr Ile Ala Ile Cys Arg 115 120 125 cct ctg cac tgt tca act gtc atg aac cct aga gcc tgc tat gca atg 432 Pro Leu His Cys Ser Thr Val Met Asn Pro Arg Ala Cys Tyr Ala Met 130 135 140 atg ttg gct ctg tgg ctt ggg ggt ttt gtc cac tcc att atc cag gtg 480 Met Leu Ala Leu Trp Leu Gly Gly Phe Val His Ser Ile Ile Gln Val 145 150 155 160 gtc ctc atc ctc cgc ttg cct ttt tgt ggc cca aac cag ctg gac aac 528 Val Leu Ile Leu Arg Leu Pro Phe Cys Gly Pro Asn Gln Leu Asp Asn 165 170 175 ttc ttc tgt gat gtc cga cag gtc atc aag ctg gct tgc acc gac atg 576 Phe Phe Cys Asp Val Arg Gln Val Ile Lys Leu Ala Cys Thr Asp Met 180 185 190 ttt gtg gtg gag ctt ctg atg gtc ttc aac agt ggc ctg atg aca ctc 624 Phe Val Val Glu Leu Leu Met Val Phe Asn Ser Gly Leu Met Thr Leu 195 200 205 ctg tgc ttt ctg ggg ctt ctg gct tcc tat gca gtc atc ctc tgc cat 672 Leu Cys Phe Leu Gly Leu Leu Ala Ser Tyr Ala Val Ile Leu Cys His 210 215 220 gtt cgt agg gca gct tct gaa ggg aag aac aag gcc atg tcc atg tgc 720 Val Arg Arg Ala Ala Ser Glu Gly Lys Asn Lys Ala Met Ser Met Cys 225 230 235 240 acc act cgt gtc att att ata ctt ctt atg ttt gga cct gct atc ttc 768 Thr Thr Arg Val Ile Ile Ile Leu Leu Met Phe Gly Pro Ala Ile Phe 245 250 255 atc tac atg tgc cct ttc agg gcc tta cca gct gac aag atg gtt tct 816 Ile Tyr Met Cys Pro Phe Arg Ala Leu Pro Ala Asp Lys Met Val Ser 260 265 270 ctc ttt cac aca gtg atc ttt cca ttg atg aat cct atg att tat acc 864 Leu Phe His Thr Val Ile Phe Pro Leu Met Asn Pro Met Ile Tyr Thr 275 280 285 ctt cgc aac cag gaa gtg aaa act tcc atg aag agg tta ttg agt cga 912 Leu Arg Asn Gln Glu Val Lys Thr Ser Met Lys Arg Leu Leu Ser Arg 290 295 300 cat gta gtc tgt caa gtg gat ttt ata ata aga aac tga 951 His Val Val Cys Gln Val Asp Phe Ile Ile Arg Asn 305 310 315 <210> 114 <2 11> 316 <212> PRT <213> Homo sapiens <400> 114 Met Lys Ile Ala Asn Asn Thr Val Val Thr Glu Phe Ile Leu Leu Gly 1 5 10 15 Leu Thr Gln Ser Gln Asp Ile Gln Leu Leu Val Phe Val Leu Ile Leu 20 25 30 Ile Phe Tyr Leu Ile Ile Leu Pro Gly Asn Phe Leu Ile Ile Phe Thr 35 40 45 Ile Arg Ser Asp Pro Gly Leu Thr Ala Pro Leu Tyr Phe Phe Leu Gly 50 55 60 Asn Leu Ala Phe Leu Asp Ala Ser Tyr Ser Phe Ile Val Ala Pro Arg 65 70 75 80 Met Leu Val Asp Phe Phe Ser Glu Lys Lys Val Ile Ser Tyr Arg Gly 85 90 95 Cys Ile Thr Gln Leu Phe Phe Leu His Phe Leu Gly Gly Gly Glu Gly 100 105 110 Leu Leu Leu Val Val Met Ala Phe Asp Arg Tyr Ile Ala Ile Cys Arg 115 120 125 Pro Leu His Cys Ser Thr Val Met Asn Pro Arg Ala Cys Tyr Ala Met 130 135 140 Met Leu Ala Leu Trp Leu Gly Gly Phe Val His Ser Ile Ile Gln Val 145 150 155 160 Val Leu Ile Leu Arg Leu Pro Phe Cys Gly Pro Asn Gln Leu Asp Asn 165 170 175 Phe Phe Cys Asp Val Arg Gln Val Ile Lys Leu Ala Cys Thr Asp Met 180 185 190 Phe Val Val Glu Leu Leu Met Val Phe Asn Ser Gly Leu Met Thr Leu 195 200 205 Leu Cys Phe Leu Gly Leu Leu Ala Ser Tyr Ala Val Ile Leu Cys His 210 215 220 Val Arg Arg Ala Ala Ser Glu Gly Lys Asn Lys Ala Met Ser Met Cys 225 230 235 240 Thr Thr Arg Val Ile Ile Ile Leu Leu Met Phe Gly Pro Ala Ile Phe 245 250 255 Ile Tyr Met Cys Pro Phe Arg Ala Leu Pro Ala Asp Lys Met Val Ser 260 265 270 Leu Phe His Thr Val Ile Phe Pro Leu Met Asn Pro Met Ile Tyr Thr 275 280 285 Leu Arg Asn Gln Glu Val Lys Thr Ser Met Lys Arg Leu Leu Ser Arg 290 295 300 His Val Val Cys Gln Val Asp Phe Ile Ile Arg Asn 305 310 315 <210> 115 <211> 684 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(684) <400> 115 atg ttg gtg gac ttc ctc tct gag aag aag gta atc tcc tac aga ggc 48 Met Leu Val Asp Phe Leu Ser Glu Lys Lys Val Ile Ser Tyr Arg Gly 1 5 10 15 tgc atc act cag ctc ttt ttc ttg cac ttc ctt gga gga ggg gag gga 96 Cys Ile Thr Gln Leu Phe Phe Leu His Phe Leu Gly Gly Gly Glu Gly 20 25 30 tta ctc ctt gtt gtg atg gcc ttt gac tgc tac atc acc atc tgc ctg 144 Leu Leu Leu Val Val Met Ala Phe Asp Cys Tyr Ile Thr Ile Cys Leu 35 40 45 cct ctg cag tat tca act gtc atg aac tct aga gcc tgc tat gca atg 192 Pro Leu Gln Tyr Ser Thr Val Met Asn Ser Arg Ala Cys Tyr Ala Met 50 55 60 atg ttg gct ctg tgg ctt ggg ggt ttt gtc cac tcc att atc cag gtg 240 Met Leu Ala Leu Trp Leu Gly Gly Phe Val His Ser Ile Ile Gln Val 65 70 75 80 gtc ctc atc atc cgc ttg cct ttt tgt ggc cca aac cag ctg gac aac 288 Val Leu Ile Ile Arg Leu Pro Phe Cys Gly Pro Asn Gln Leu Asp Asn 85 90 95 ttc ttc tgt gat gtc cga cag gtc atc aag ctg gct tgc acc gac atg 336 Phe Phe Cys Asp Val Arg Gln Val Ile Lys Leu Ala Cys Thr Asp Met 100 105 110 ttt gtg gtg gag ctt ctg atg gtc ttc aat agt ggc ctg atg aca ctc 384 Phe Val Val Glu Leu Leu Met Val Phe Asn Ser Gly Leu Met Thr Leu 115 120 125 atg tgc ttt ctg gga ctt ctg gcc tcc tat gca gtc att ctt tgt cgc 432 Met Cys Phe Leu Gly Leu Leu Ala Ser Tyr Ala Val Ile Leu Cys Arg 130 135 140 ata cga gcg tct tct tct gag gca aaa aac aag gcc atg tcc aca tgc 480 Ile Arg Ala Ser Ser Ser Glu Ala Lys Asn Lys Ala Met Ser Thr Cys 145 150 155 160 acc acc cat atc att gtt ata ttc ttc atg ttt gga cct ggc atc ttc 528 Thr Thr His Ile Ile Val Ile Phe Phe Met Phe Gly Pro Gly Ile Phe 165 170 175 atc tac acg tgc ccc ttc agg gct ttc cca gcc gac aag gtg gtt tct 576 Ile Tyr Thr Cys Pro Phe Arg Ala Phe Pro Ala Asp Lys Val Val Ser 180 185 190 ctc ttc cac aca gtg att ctt cct ttg ttg aat cct gtc att tat acc 624 Leu Phe His Thr Val Ile Leu Pro Leu Leu Asn Pro Val Ile Tyr Thr 195 200 205 ctt cat aac cag gaa gtg aaa gct tcc atg aaa aag gtg ttt aat aaa 672 Leu His Asn Gln Glu Val Lys Ala Ser Met Lys Lys Val Phe Asn Lys 210 215 220 cac ata gcc tga 684 His Ile Ala 225 <210> 116 <211> 227 <212> PRT <213> Homo sapiens <400> 116 Met Leu Val Asp Phe Leu Ser Glu Lys Lys Val Ile Ser Tyr Arg Gly 1 5 10 15 Cys Ile Thr Gln Leu Phe Phe Leu His Phe Leu Gly Gly Gly Glu Gly 20 25 30 Leu Leu Leu Val Val Met Ala Phe Asp Cys Tyr Ile Thr Ile Cys Leu 35 40 45 Pro Leu Gln Tyr Ser Thr Val Met Asn Ser Arg Ala Cys Tyr Ala Met 50 55 60 Met Leu Ala Leu Trp Leu Gly Gly Phe Val His Ser Ile Ile Gln Val 65 70 75 80 Val Leu Ile Ile Arg Leu Pro Phe Cys Gly Pro Asn Gln Leu Asp Asn 85 90 95 Phe Phe Cys Asp Val Arg Gln Val Ile Lys Leu Ala Cys Thr Asp Met 100 105 110 Phe Val Val Glu Leu Leu Met Val Phe Asn Ser Gly Leu Met Thr Leu 115 120 125 Met Cys Phe Leu Gly Leu Leu Ala Ser Tyr Ala Val Ile Leu Cys Arg 130 135 140 Ile Arg Ala Ser Ser Ser Glu Ala Lys Asn Lys Ala Met Ser Thr Cys 145 150 155 160 Thr Thr His Ile Ile Val Ile Phe Phe Met Phe Gly Pro Gly Ile Phe 165 170 175 Ile Tyr Thr Cys Pro Phe Arg Ala Phe Pro Ala Asp Lys Val Val Ser 180 185 190 Leu Phe His Thr Val Ile Leu Pro Leu Leu Asn Pro Val Ile Tyr Thr 195 200 205 Leu His Asn Gln Glu Val Lys Ala Ser Met Lys Lys Val Phe Asn Lys 210 215 220 His Ile Ala 225 <210> 117 <211> 942 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(942) <400> 117 atg gaa act gca aat tac acc aag gtg aca gaa ttt gtt ctc act ggc 48 Met Glu Thr Ala Asn Tyr Thr Lys Val Thr Glu Phe Val Leu Thr Gly 1 5 10 15 cta tcc cag act cca gag gtc caa cta gtc cta ttt gtt ata ttt cta 96 Leu Ser Gln Thr Pro Glu Val Gln Leu Val Leu Phe Val Ile Phe Leu 20 25 30 tcc ttc tat ttg ttc atc cta cca gga aat atc ctt atc att tgc acc 144 Ser Phe Tyr Leu Phe Ile Leu Pro Gly Asn Ile Leu Ile Ile Cys Thr 35 40 45 atc agt cta gac cct cat ctg acc tct cct atg tat ttc ctg ttg gct 192 Ile Ser Leu Asp Pro His Leu Thr Ser Pro Met Tyr Phe Leu Leu Ala 50 55 60 aat ctg gcc ttc ctt gat att tgg tac tct tcc att aca gcc cct gaa 240 Asn Leu Ala Phe Leu Asp Ile Trp Tyr Ser Ser Ile Thr Ala Pro Glu 65 70 75 80 atg ctc ata gac ttc ttt gtg gag agg aag ata att tct ttt gat gga 288 Me t Leu Ile Asp Phe Phe Val Glu Arg Lys Ile Ile Ser Phe Asp Gly 85 90 95 tgc att gca cag ctc ttc ttc tta cac ttt gct ggg gct tcg gag atg 336 Cys Ile Ala Gln Leu Phe Phe Leu His Phe Ala Gly Ala Ser Glu Met 100 105 110 ttc ttg ctc aca gtg atg gcc ttt gac ctc tac act gct atc tgc cga 384 Phe Leu Leu Thr Val Met Ala Phe Asp Leu Tyr Thr Ala Ile Cys Arg 115 120 125 ccc ctc cac tat gct acc atc atg aat caa cgt ctc tgc tgt atc ctg 432 Pro Leu His Tyr Ala Thr Ile Met Asn Gln Arg Leu Cys Cys Ile Leu 130 135 140 gtg gct ctc tcc tgg agg ggg ggc ttc att cat tct atc ata cag gtg 480 Val Ala Leu Ser Trp Arg Gly Gly Phe Ile His Ser Ile Ile Gln Val 145 150 155 160 gct ctc att gtt cga ctt cct ttc tgt ggg ccc aat gag tta gac agt 528 Ala Leu Ile Val Arg Leu Pro Phe Cys Gly Pro Asn Glu Leu Asp Ser 165 170 175 tac ttc tgt gac atc aca cag gtt gtc cgg att gcc tgt gcc aac acc 576 Tyr Phe Cys Asp Ile Thr Gln Val Val Arg Ile Ala Cys Ala Asn Thr 180 185 190 ttc cca gag gag tta gtg atg atc tgt agt agt ggt ctg atc tct gtg 624 Phe Pro Glu Glu Leu Val Met Ile Cys Ser Ser Gly Leu Ile Ser Val 195 200 205 gtg tgt ttg att gct ctg tta atg tcc tat gcc ttc ctt ctg gcc ttg 672 Val Cys Leu Ile Ala Leu Leu Met Ser Tyr Ala Phe Leu Leu Ala Leu 210 215 220 ttc aag aaa ctt tca ggc tca ggt gag aat acc aac agg gcc atg tcc 720 Phe Lys Lys Leu Ser Gly Ser Gly Glu Asn Thr Asn Arg Ala Met Ser 225 230 235 240 acc tgc tat tcc cac att acc att gtg gtg cta atg ttt ggg cca tcc 768 Thr Cys Tyr Ser His Ile Thr Ile Val Val Leu Met Phe Gly Pro Ser 245 250 255 atc tac att tat gct cgc cca ttt gac tcg ttt tcc cta gat aaa gtg 816 Ile Tyr Ile Tyr Ala Arg Pro Phe Asp Ser Phe Ser Leu Asp Lys Val 260 265 270 gtg tct gtg ttc aat act tta ata ttc cct tta cgt aat ccc att att 864 Val Ser Val Phe Asn Thr Leu Ile Phe Pro Leu Arg Asn Pro Ile Ile 275 280 285 tac aca ttg aga aac aag gaa gta aag gca gcc atg agg aag ttg gtc 912 Tyr Thr Leu Arg Asn Lys Glu Val Lys Ala Ala Met Arg Lys Leu Val 290 295 300 acc aaa tat att ttg tgt aaa gag aag tga 942 Thr Lys Tyr Ile Leu Cys Lys Glu Lys 305 310 <210> 118 <211> 313 <212> PRT <213> Homo sapiens <400> 118 Met Glu Thr Ala Asn Tyr Thr Lys Val Thr Glu Phe Val Leu Thr Gly 1 5 10 15 Leu Ser Gln Thr Pro Glu Val Gln Leu Val Leu Phe Val Ile Phe Leu 20 25 30 Ser Phe Tyr Leu Phe Ile Leu Pro Gly Asn Ile Leu Ile Ile Cys Thr 35 40 45 Ile Ser Leu Asp Pro His Leu Thr Ser Pro Met Tyr Phe Leu Leu Ala 50 55 60 Asn Leu Ala Phe Leu Asp Ile Trp Tyr Ser Ser Ile Thr Ala Pro Glu 65 70 75 80 Met Leu Ile Asp Phe Phe Val Glu Arg Lys Ile Ile Ser Phe Asp Gly 85 90 95 Cys Ile Ala Gln Leu Phe Phe Leu His Phe Ala Gly Ala Ser Glu Met 100 105 110 Phe Leu Leu Thr Val Met Ala Phe Asp Leu Tyr Thr Ala Ile Cys Arg 115 120 125 Pro Leu His Tyr Ala Thr Ile Met Asn Gln Arg Leu Cys Cys Ile Leu 130 135 140 Val Ala Leu Ser Trp Arg Gly Gly Phe Ile His Ser Ile Ile Gln Val 145 150 155 160 Ala Leu Ile Val Arg Leu Pro Phe Cys Gly Pro Asn Glu Leu Asp Ser 165 170 175 Tyr Phe Cys Asp Ile Thr Gln Val Val Arg Ile Ala Cys Ala Asn Thr 180 185 190 Phe Pro Glu Glu Leu Val Met Ile Cys Ser Ser Gly Leu Ile Ser Val 195 200 205 Val Cys Leu Ile Ala Leu Leu Met Ser Tyr Ala Phe Leu Leu Ala Leu 210 215 220 Phe Lys Lys Leu Ser Gly Ser Gly Glu Asn Thr Asn Arg Ala Met Ser 225 230 235 240 Thr Cys Tyr Ser His Ile Thr Ile Val Val Leu Met Phe Gly Pro Ser 245 250 255 Ile Tyr Ile Tyr Ala Arg Pro Phe Asp Ser Phe Ser Leu Asp Lys Val 260 265 270 Val Ser Val Phe Asn Thr Leu Ile Phe Pro Leu Arg Asn Pro Ile Ile 275 280 285 Tyr Thr Leu Arg Asn Lys Glu Val Lys Ala Ala Met Arg Lys Leu Val 290 295 300 Thr Lys Tyr Ile Leu Cys Lys Glu Lys 305 310 <210> 119 <21 1> 807 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(807) <400> 119 atg gat gac gaa aat gca aca ttg ctg aca gag ttt gtt ctc aca gga 48 Met Asp Asp Glu Asn Ala Thr Leu Leu Thr Glu Phe Val Leu Thr Gly 1 5 10 15 ctt aca tat caa tca gag tgg aaa ata ccc ctg ttc ctg gca ttc ttg 96 Leu Thr Tyr Gln Ser Glu Trp Lys Ile Pro Leu Phe Leu Ala Phe Leu 20 25 30 gta ata tat ctc atc acc atc atg gca aat ctt ggt ctg att gct gtc 144 Val Ile Tyr Leu Ile Thr Ile Met Ala Asn Leu Gly Leu Ile Ala Val 35 40 45 atc tgg aaa gac tca cac ctt cac att cca atg tac tta ttc ctt ggg 192 Ile Trp Lys Asp Ser His Leu His Ile Pro Met Tyr Leu Phe Leu Gly 50 55 60 agt tta gcc ttt gtg gat gct tgg tta tca tcc tca gtg acc cct aag 240 Ser Leu Ala Phe Val Asp Ala Trp Leu Ser Ser Ser Val Thr Pro Lys 65 70 75 80 atg ctg atc agc ttt tta gct aag agt atg att att tct gtc tct gaa 288 Met Leu Ile Ser Phe Leu Ala Lys Ser Met Ile Ile Ser Val Ser Glu 85 90 95 tgc aag ata caa ttt ttt tcc ttt gga atc agt gga acc aca gaa tgt 336 Cys Lys Ile Gln Phe Phe Ser Phe Gly Ile Ser Gly Thr Thr Glu Cys 100 105 110 ttt ctc ttg gca aca atg gca tat gat cgc tat gta gcc ata tgc aaa 384 Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys 115 120 125 cct tta ctt tat cca gtc att atg acc aat gga ctg tgt atc tgg cta 432 Pro Leu Leu Tyr Pro Val Ile Met Thr Asn Gly Leu Cys Ile Trp Leu 130 135 140 tta gtc ttg tca ttt ata ggt ggc ttt ctt cat gcc tta att cat gaa 480 Leu Val Leu Ser Phe Ile Gly Gly Phe Leu His Ala Leu Ile His Glu 145 150 155 160 ggt att tta ttc aga tta acc ttc tgt aat tcc aac ata ata cat cac 528 Gly Ile Leu Phe Arg Leu Thr Phe Cys Asn Ser Asn Ile Ile His His 165 170 175 ttt tac tgt gac att atc cca ttg tta aag att tcc tgt act gac cct 576 Phe Tyr Cys Asp Ile Ile Pro Leu Leu Lys Ile Ser Cys Thr Asp Pro 180 185 190 tct att aat ttt tta atg ctt ttt att ttg tct ggt tca ata cag gta 624 Ser Ile Asn Phe Leu Met Leu Phe Ile Leu Ser Gly Ser Ile Gln Val 195 200 205 ttc act att ttg act gtt ctt gtc tct tat aca ttt gtc ctc ttt aca 672 Phe Thr Ile Leu Thr Val Leu Val Ser Tyr Thr Phe Val Leu Phe Thr 210 215 220 atc tta aaa aaa aaa gtc tgc caa aga cat aag gaa agc ctt ttc cac 720 Ile Leu Lys Lys Lys Val Cys Gln Arg His Lys Glu Ser Leu Phe His 225 230 235 240 ctg tgg agc cca tct ctt atc tgt ttc ttt ata cta tgg ccc cct tct 768 Leu Trp Ser Pro Ser Leu Ile Cys Phe Phe Ile Leu Trp Pro Pro Ser 245 250 255 ctt cat gta tgt gca ccc tgc atc tcc aca agc aga tga 807 Leu His Val Cys Ala Pro Cys Ile Ser Thr Ser Arg 260 265 <210> 120 <211> 268 <212> PRT <213> Homo sapiens <400> 120 Met Asp Asp Glu Asn Ala Thr Leu Leu Thr Glu Phe Val Leu Thr Gly 1 5 10 15 Leu Thr Tyr Gln Ser Glu Trp Lys Ile Pro Leu Phe Leu Ala Phe Leu 20 25 30 Val Ile Tyr Leu Ile Thr Ile Met Ala Asn Leu Gly Leu Ile Ala Val 35 40 45 Ile Trp Lys Asp Ser His Leu His Ile Pro Met Tyr Leu Phe Leu Gly 50 55 60 Ser Leu Ala Phe Val Asp Ala Trp Leu Ser Ser Ser Val Thr Pro Lys 65 70 75 80 Met Leu Ile Ser Phe Leu Ala Lys Ser Met Ile Ile Ser Val Ser Glu 85 90 95 Cys Lys Ile Gln Phe Phe Ser Phe Gly Ile Ser Gly Thr Thr Glu Cys 100 105 110 Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys 115 120 125 Pro Leu Leu Tyr Pro Val Ile Met Thr Asn Gly Leu Cys Ile Trp Leu 130 135 140 Leu Val Leu Ser Phe Ile Gly Gly Phe Leu His Ala Leu Ile His Glu 145 150 155 160 Gly Ile Leu Phe Arg Leu Thr Phe Cys Asn Ser Asn Ile Ile His His 165 170 175 Phe Tyr Cys Asp Ile Ile Pro Leu Leu Lys Ile Ser Cys Thr Asp Pro 180 185 190 Ser Ile Asn Phe Leu Met Leu Phe Ile Leu Ser Gly Ser Ile Gln Val 195 200 205 Phe Thr Ile Leu Thr Val Leu Val Ser Tyr Thr Phe Val Leu Phe Thr 210 215 220 Ile Leu Lys Lys Lys Val Cys Gln Arg His Lys Glu Ser Leu Phe His 225 230 235 240 Leu Trp Ser Pro Ser Leu Ile Cys Phe Phe Ile Leu Trp Pro Pro Ser 245 250 255 Leu His Val Cys Ala Pro Cys Ile Ser Thr Ser Arg 260 265 <210> 121 <211> 1098 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1098) <400> 121 atg atg aca gtg att tta aaa act tta ttg gga cag ata cag ggc ctc 48 Met Met Thr Val Ile Leu Lys Thr Leu Leu Gly Gln Ile Gln Gly Leu 1 5 10 15 agt gga aac cca cac tct act acg tct aga atg tac ttt tta tgt ttc 96 Ser Gly Asn Pro His Ser Thr Thr Ser Arg Met Tyr Phe Leu Cys Phe 20 25 30 tgt act tct cta cta ggt ttt aag gta cac tgg gtc tcc aga ttg atc 144 Cys Thr Ser Leu Leu Gly Phe Lys Val His Trp Val Ser Arg Leu Ile 35 40 45 ang aaa ctt tac atg gca tct ccc aac aat gac tcc act gcc cca gtc 192 Xaa Lys Leu Tyr Met Ala Ser Pro Asn Asn Asp Ser Thr Ala Pro Val 50 55 60 tct gaa ttc ctc ctc atc tgc ttc ccc aac ttc cag agc tgg cag cac 240 Ser Glu Phe Leu Leu Ile Cys Phe Pro Asn Phe Gln Ser Trp Gln His 65 70 75 80 tgg ttg tct ctg ccc ctc agc ctt ctc ttc ctc ctg gcc atg gga gct 288 Trp Leu Ser Leu Pro Leu Ser Leu Leu Phe Leu Leu Ala Met Gly Ala 85 90 95 aac acc acc ctc ctg atc acc atc cag ctg gag gcc tct ctg cac cag 336 Asn Thr Thr Leu Leu Ile Thr Ile Gln Leu Glu Ala Ser Leu His Gln 100 105 110 ccc ctg tac tac ctg ctc agc ctc ctc tcc ctg ctg gac atc gtg ctc 384 Pro Leu Tyr Tyr Leu Leu Ser Leu Leu Ser Leu Leu Asp Ile Val Leu 115 120 125 tgc ctc acc gtc atc ccc aag gtc ctg gcc atc ttc tgg ttt gac ctc 432 Cys Leu Thr Val Ile Pro Lys Val Leu Ala Ile Phe Trp Phe Asp Leu 130 135 140 agg tcg atc agc ttc cca gcc tgc ttc ctc cag atg ttc atc atg aac 480 Arg Ser Ile Ser Phe Pro Ala Cys Phe Leu Gln Met Phe Ile Met Asn 145 150 155 160 agt ttt ttg acc atg gag tcc tgc acg ttc atg gtc atg gcc tat gac 528 Ser Phe Leu Thr Met Glu Ser Cys Thr Phe Met Val Met Ala Tyr Asp 165 170 175 cgt tat gtg gcc atc tgc cat cca ttg aga tac ccg tct atc atc act 576 Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr Pro Ser Ile Ile Thr 180 185 190 gac cag ttt gtg gct agg gcc gtg gtc ttt gtt ata gcc cgg aat gcc 624 Asp Gln Phe Val Ala Arg Ala Val Val Phe Val Ile Ala Arg Asn Ala 195 200 205 ttt gtt tct ctt cct gtt ccc atg ctt tct gcc agg ctc aga tac tgt 672 Phe Val Ser Leu Pro Val Pro Met Leu Ser Ala Arg Leu Arg Tyr Cys 210 215 220 gca gga aac ata atc aag aac tgc atc tgc agt aac ctg tct gtg tcc 720 Ala Gly Asn Ile Ile Lys Asn Cys Ile Cys Ser Asn Leu Ser Val Ser 225 230 235 240 aaa ctc tct tgt gat gac atc act ttc aat cag ctc tac cag ttt gtg 768 Lys Leu Ser Cys Asp Asp Ile Thr Phe Asn Gln Leu Tyr Gln Phe Val 245 250 255 gca ggc tgg act ctg ttg ggc tct gat ctt atc ctt att gtt atc tcc 816 Ala Gly Trp Thr Leu Leu Gly Ser Asp Leu Ile Leu Ile Val Ile Ser 260 265 270 tat tct ttt ata ttg aaa gtt gtg ctt agg atc aag gcc gag ggt gct 864 Tyr Ser Phe Ile Leu Lys Val Val Leu Arg Ile Lys Ala Glu Gly Ala 275 280 285 gtg gcc aag gcc ttg agc acg tgt ggt tcc cac ttc atc ctc atc ctc 912 Val Ala Lys Ala Leu Ser Thr Cys Gly Ser His Phe Ile Leu Ile Leu 290 295 300 ttc ttc agc aca gtc ctg ctg gtt ctg gtc atc act aac ctg gcc agg 960 Phe Phe Ser Thr Val Leu Leu Val Leu Val Ile Thr Asn Leu Ala Arg 305 310 315 320 aag aga att cct cca gat gtc ccc atc ctg ctc aac atc ctg cac cac 1008 Lys Arg Ile Pro Pro Asp Val Pro Ile Leu Leu Asn Ile Leu His His 325 330 335 ctc att ccc cca gct ctg aac ccc att gtt tat ggt gtg aga acc aag 1056 Leu Ile Pro Pro Ala Leu Asn Pro Ile Val Tyr Gly Val Arg Thr Lys 340 345 350 gag atc aag cag gga atc caa aac ctg ctg aag agg ttg taa 1098 Glu Ile Lys Gln Gly Ile Gln Asn Leu Leu Lys Arg Leu 355 360 365 <210> 122 <211> 365 <212> PRT <213> Homo sapiens <400> 122 Met Met Thr Val Ile Leu Lys Thr Leu Leu Gly Gln Ile Gln Gly Leu 1 5 10 15 Ser Gly Asn Pro His Ser Thr Thr Ser Arg Met Tyr Phe Leu Cys Phe 20 25 30 Cys Thr Ser Leu Leu Gly Phe Lys Val His Trp Val Ser Arg Leu Ile 35 40 45 Xaa Lys Leu Tyr Met Ala Ser Pro Asn Asn Asp Ser Thr Ala Pro Val 50 55 60 Ser Glu Phe Leu Leu Ile Cys Phe Pro Asn Phe Gln Ser Trp Gln His 65 70 75 80 Trp Leu Ser Leu Pro Leu Ser Leu Leu Phe Leu Leu Ala Met Gly Ala 85 90 95 Asn Thr Thr Leu Leu Ile Thr Ile Gln Leu Glu Ala Ser Leu His Gln 100 105 110 Pro Leu Tyr Tyr Leu Leu Ser Leu Leu Ser Leu Leu Asp Ile Val Leu 115 120 125 Cys Leu Thr Val Ile Pro Lys Val Leu Ala Ile Phe Trp Phe Asp Leu 130 135 140 Arg Ser Ile Ser Phe Pro Ala Cys Phe Leu Gln Met Phe Ile Met Asn 145 150 155 160 Ser Phe Leu Thr Met Glu Ser Cys Thr Phe Met Val Met Ala Tyr Asp 165 170 175 Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr Pro Ser Ile Ile Thr 180 185 190 Asp Gln Phe Val Ala Arg Ala Val Val Phe Val Ile Ala Arg Asn Ala 195 200 205 Phe Val Ser Leu Pro Val Pro Met Leu Ser Ala Arg Leu Arg Tyr Cys 210 215 220 Ala Gly Asn Ile Ile Lys Asn Cys Ile Cys Ser Asn Leu Ser Val Ser 225 230 235 240 Lys Leu Ser Cys Asp Asp Ile Thr Phe Asn Gln Leu Tyr Gln Phe Val 245 250 255 Ala Gly Trp Thr Leu Leu Gly Ser Asp Leu Ile Leu Ile Val Ile Ser 260 265 270 Tyr Ser Phe Ile Leu Lys Val Val Leu Arg Ile Lys Ala Glu Gly Ala 275 280 285 Val Ala Lys Ala Leu Ser Thr Cys Gly Ser His Phe Ile Leu Ile Leu 290 295 300 Phe Phe Ser Thr Val Leu Leu Val Leu Val Ile Thr Asn Leu Ala Arg 305 310 315 320 Lys Arg Ile Pro Pro Asp Val Pro Ile Leu Leu Asn Ile Leu His His 325 330 335 Leu Ile Pro Pro Ala Leu Asn Pro Ile Val Tyr Gly Val Arg Thr Lys 340 345 350 Glu Ile Lys Gln Gly Ile Gln Asn Leu Leu Lys Arg Leu 355 360 365 <210> 123 <211> 957 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(957) <400> 123 atg att cag cct atg gcg tca ccc agc aac agc tcc act gtc cca gtc 48 Met Ile Gln Pro Met Ala Ser Pro Ser Asn Ser Ser Thr Val Pro Val 1 5 10 15 tct gaa ttc ctc ctc acc tgc ttc ccc aac ttc cag agt tgg cag cac 96 Ser Glu Phe Leu Leu Thr Cys Phe Pro Asn Phe Gln Ser Trp Gln His 20 25 30 tgg ctc tcc ctg ccc ctc agc ctt ctc ttc ctc ctg gcc atg gga gct 144 Trp Leu Ser Leu Pro Leu Ser Leu Leu Phe Leu Leu Ala Met Gly Ala 35 40 45 aac acc acc ctc ctg atc acc atc cag ctg gag gcc tct ctg cac cag 192 Asn Thr Thr Leu Leu Ile Thr Ile Gln Leu Glu Ala Ser Leu His Gln 50 55 60 ccc ctg tac tac ctg ctc agc ctc ctc tcc ctg ctg gac atc gtg ctc 240 Pro Leu Tyr Tyr Leu Leu Ser Leu Leu Ser Leu Leu Asp Ile Val Leu 65 70 75 80 tgc ctc acc gtc atc ccc aag gtc ctg gcc atc ttc tgg tat gat ctt 288 Cys Leu Thr Val Ile Pro Lys Val Leu Ala Ile Phe Trp Tyr Asp Leu 85 90 95 agg tcg atc agc ttc cct gcc tgc ttc ctc cag atg ttc atc atg aac 336 Arg Ser Ile Ser Phe Pro Ala Cys Phe Leu Gln Met Phe Ile Met Asn 100 105 110 agt ttc ctc ccc atg gag tcc tgc acg ttt atg gtc atg gcc tat gac 384 Ser Phe Leu Pro Met Glu Ser Cys Thr Phe Met Val Met Ala Tyr Asp 115 120 125 cgt tat gtg gcc atc tgc cac cca ctg cgg tac cca tcc atc atc act 432 Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr Pro Ser Ile Ile Thr 130 135 140 aat caa ttt gtg gcc aaa gct agt gtc ttc att gtg gtg cgg aat gcg 480 Asn Gln Phe Val Ala Lys Ala Ser Val Phe Ile Val Val Arg Asn Ala 145 150 155 160 ctt ctt act gca ccc att cct atc ctc act tcc ctg ctc cat tac tgt 528 Leu Leu Thr Ala Pro Ile Pro Ile Leu Thr Ser Leu Leu His Tyr Cys 165 170 175 ggg gaa aat gtc att gag aac tgc atc tgt gcc aac ttg tct gtg tcc 576 Gly Glu Asn Val Ile Glu Asn Cys Ile Cys Ala Asn Leu Ser Val Ser 180 185 190 agg ctc tcc tgt gat aat ttc acc ctt aac aga atc tac caa ttt gtg 624 Arg Leu Ser Cys Asp Asn Phe Thr Leu Asn Arg Ile Tyr Gln Phe Val 195 200 205 gct ggt tgg acc ttg ctg ggc tca gat tta ttc ctc atc ttc ctc tct 672 Ala Gly Trp Thr Leu Leu Gly Ser Asp Leu Phe Leu Ile Phe Leu Ser 210 215 220 tac acc ttc att cta aga gct gtg ctt aga ttc aaa gca gag ggg gcg 720 T yr Thr Phe Ile Leu Arg Ala Val Leu Arg Phe Lys Ala Glu Gly Ala 225 230 235 240 gca gtg aag gcc ctg agc aca tgt ggc tcc cac ttc atc ctc att ctt 768 Ala Val Lys Ala Leu Ser Thr Cys Gly Ser His Phe Ile Leu Ile Leu 245 250 255 ttc ttc agc acc ata ctg ctg gtt gtg gtg ttg aca aac gtg gcc aga 816 Phe Phe Ser Thr Ile Leu Leu Val Val Val Leu Thr Asn Val Ala Arg 260 265 270 aag aag gtc ccc atg gac atc ctg atc ctg ctg aac gtc ctt cat cac 864 Lys Lys Val Pro Met Asp Ile Leu Ile Leu Leu Asn Val Leu His His 275 280 285 ctt att cct cct gcg ttg aac cct att gtg tat ggg gtt cgg acc aaa 912 Leu Ile Pro Pro Ala Leu Asn Pro Ile Val Tyr Gly Val Arg Thr Lys 290 295 300 gag ata aaa cag gga att cag aag tta ctg cag aga ggg agg tga 957 Glu Ile Lys Gln Gly Ile Gln Lys Leu Leu Gln Arg Gly Arg 305 310 315 <210> 124 <211> 318 <212> PRT <213> Homo sapiens <400> 124 Met Ile Gln Pro Met Ala Ser Pro Ser Asn Ser Ser Thr Val Pro Val 1 5 10 15 Ser Glu Phe Leu Leu Thr Cys Phe Pro Asn Phe Gln Ser Trp Gln His 20 25 30 Trp Leu Ser Leu Pro Leu Ser Leu Leu Phe Leu Leu Ala Met Gly Ala 35 40 45 Asn Thr Thr Leu Leu Ile Thr Ile Gln Leu Glu Ala Ser Leu His Gln 50 55 60 Pro Leu Tyr Tyr Leu Leu Ser Leu Leu Ser Leu Leu Asp Ile Val Leu 65 70 75 80 Cys Leu Thr Val Ile Pro Lys Val Leu Ala Ile Phe Trp Tyr Asp Leu 85 90 95 Arg Ser Ile Ser Phe Pro Ala Cys Phe Leu Gln Met Phe Ile Met Asn 100 105 110 Ser Phe Leu Pro Met Glu Ser Cys Thr Phe Met Val Met Ala Tyr Asp 115 120 125 Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr Pro Ser Ile Ile Thr 130 135 140 Asn Gln Phe Val Ala Lys Ala Ser Val Phe Ile Val Val Arg Asn Ala 145 150 155 160 Leu Leu Thr Ala Pro Ile Pro Ile Leu Thr Ser Leu Leu His Tyr Cys 165 170 175 Gly Glu Asn Val Ile Glu Asn Cys Ile Cys Ala Asn Leu Ser Val Ser 180 185 190 Arg Leu Ser Cys Asp Asn Phe Thr Leu Asn Arg Ile Tyr Gln Phe Val 195 200 205 Ala Gly Trp Thr Leu Leu Gly Ser Asp Leu Phe Leu Ile Phe Leu Ser 210 215 220 Tyr Thr Phe Ile Leu Arg Ala Val Leu Arg Phe Lys Ala Glu Gly Ala 225 230 235 240 Ala Val Lys Ala Leu Ser Thr Cys Gly Ser His Phe Ile Leu Ile Leu 245 250 255 Phe Phe Ser Thr Ile Leu Leu Val Val Val Leu Thr Asn Val Ala Arg 260 265 270 Lys Lys Val Pro Met Asp Ile Leu Ile Leu Leu Asn Val Leu His His 275 280 285 Leu Ile Pro Pro Ala Leu Asn Pro Ile Val Tyr Gly Val Arg Thr Lys 290 295 300 Glu Ile Lys Gln Gly Ile Gln Lys Leu Leu Gln Arg Gly Arg 305 310 315 <210> 125 <211> 786 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(786) <400> 125 atg aca tta ccc agc gat gac tcc act gtc cca gtc tct gaa ttc ctc 48 Met Thr Leu Pro Ser Asp Asp Ser Thr Val Pro Val Ser Glu Phe Leu 1 5 10 15 ctc atc tgc ttc ccc aac ttt cag agt tgg cag cac ttg ctg tcc ctg 96 Leu Ile Cys Phe Pro Asn Phe Gln Ser Trp Gln His Leu Leu Ser Leu 20 25 30 ccc ctc agc ctc att tcc tcc tgg cca tgg gga cca aca ccc acc ccc 144 Pro Leu Ser Leu Ile Ser Ser Trp Pro Trp Gly Pro Thr Pro Thr Pro 35 40 45 ccc atc acc atc cac ctg gag gcc tct ctg cac ctg ccc ctg tac tac 192 Pro Ile Thr Ile His Leu Glu Ala Ser Leu His Leu Pro Leu Tyr Tyr 50 55 60 ctg ccc agc ctc ctc tcc ctg ctg gac atc gtg ctc tgc ctc acc gtc 240 Leu Pro Ser Leu Leu Ser Leu Leu Asp Ile Val Leu Cys Leu Thr Val 65 70 75 80 atc ccc aag gtc ctg gcc atc ttc tgg ttt gat ctt agg tcg atc ggc 288 Ile Pro Lys Val Leu Ala Ile Phe Trp Phe Asp Leu Arg Ser Ile Gly 85 90 95 ttc cct gcc tgc ttc ctt cag atg ttc atc atg aac agt ttc ctc ccc 336 Phe Pro Ala Cys Phe Leu Gln Met Phe Ile Met Asn Ser Phe Leu Pro 100 105 110 atg gag tcc tgc aca ttc atg gtc aag gac tat gat cat tat gtg gcc 384 Met Glu Ser Cys Thr Phe Met Val Lys Asp Tyr Asp His Tyr Val Ala 115 120 125 atc tgc cac cca ctg cag tac ctg tcc atc atc act cat caa ttt gtg 432 Ile Cys His Pro Leu Gln Tyr Leu Ser Ile Ile Thr His Gln Phe Val 130 135 140 gcc aaa gct agt gtc ttc att gtg gtg cag aat gct ttg ctg ctt tca 480 Ala Lys Ala Ser Val Phe Ile Val Val Gln Asn Ala Leu Leu Leu Ser 145 150 155 160 cct gtt cct att ctc tct gcc cag ctc cat tac tgt agg aaa aat gtg 528 Pro Val Pro Ile Leu Ser Ala Gln Leu His Tyr Cys Arg Lys Asn Val 165 170 175 att gag aac tgc atc tgt gcc aac ctg tct gtg tcc agg ctc tcc tgt 576 Ile Glu Asn Cys Ile Cys Ala Asn Leu Ser Val Ser Arg Leu Ser Cys 180 185 190 gat aat ttc acc ctt aac aga ctc tac caa ttt gtg gct ggt tgg acc 624 Asp Asn Phe Thr Leu Asn Arg Leu Tyr Gln Phe Val Ala Gly Trp Thr 195 200 205 ttc ctg ggc tcg gat ttc atc ctc atc ttc ctc tcc tac acc ttc att 672 Phe Leu Gly Ser Asp Phe Ile Leu Ile Phe Leu Ser Tyr Thr Phe Ile 210 215 220 cta aga gct gtg ctt aga ttc aag gtg gag ggg gtg gca gtg aag gcc 720 Leu Arg Ala Val Leu Arg Phe Lys Val Glu Gly Val Ala Val Lys Ala 225 230 235 240 ctg agc aca tgt ggc tcc cac ttt atc ctc atc ctc ttc ttc agc acc 768 Leu Ser Thr Cys Gly Ser His Phe Ile Leu Ile Leu Phe Phe Ser Thr 245 250 255 tgc tgg ttg tgg tgt tga 786 Cys Trp Leu Trp Cys 260 <210> 126 <211> 261 <212> PRT <213> Homo sapiens <400> 126 Met Thr Leu Pro Ser Asp Asp Ser Thr Val Pro Val Ser Glu Phe Leu 1 5 10 15 Leu Ile Cys Phe Pro Asn Phe Gln Ser Trp Gln His Leu Leu Ser Leu 20 25 30 Pro Leu Ser Leu Ile Ser Ser Trp Pro Trp Gly Pro Thr Pro Thr Pro 35 40 45 Pro Ile Thr Ile His Leu Glu Ala Ser Leu His Leu Pro Leu Tyr Tyr 50 55 60 Leu Pro Ser Leu Leu Ser Leu Leu Asp Ile Val Leu Cys Leu Thr Val 65 70 75 80 Ile Pro Lys Val Leu Ala Ile Phe Trp Phe Asp Leu Arg Ser Ile Gly 85 90 95 Phe Pro Ala Cys Phe Leu Gln Met Phe Ile Met Asn Ser Phe Leu Pro 100 105 110 Met Glu Ser Cys Thr Phe Met Val Lys Asp Tyr Asp His Tyr Val Ala 115 120 125 Ile Cys His Pro Leu Gln Tyr Leu Ser Ile Ile Thr His Gln Phe Val 130 135 140 Ala Lys Ala Ser Val Phe Ile Val Val Gln Asn Ala Leu Leu Leu Ser 145 150 155 160 Pro Val Pro Ile Leu Ser Ala Gln Leu His Tyr Cys Arg Lys Asn Val 165 170 175 Ile Glu Asn Cys Ile Cys Ala Asn Leu Ser Val Ser Arg Leu Ser Cys 180 185 190 Asp Asn Phe Thr Leu Asn Arg Leu Tyr Gln Phe Val Ala Gly Trp Thr 195 200 205 Phe Leu Gly Ser Asp Phe Ile Leu Ile Phe Leu Ser Tyr Thr Phe Ile 210 215 220 Leu Arg Ala Val Leu Arg Phe Lys Val Glu Gly Val Ala Val Lys Ala 225 230 235 240 Leu Ser Thr Cys Gly Ser His Phe Ile Leu Ile Leu Phe Phe Ser Thr 245 250 255 Cys Trp Leu Trp Cys 260 <210> 127 <211> 939 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(939) <400> 127 atg gat gaa gcc aat cac tct gtg gtc tct gag ttt gtg ttc ctg gga 48 Met Asp Glu Ala Asn His Ser Val Val Ser Glu Phe Val Phe Leu Gly 1 5 10 15 ctc tct gac tcg cgg aag atc cag ctc ctc ctc ttc ctc ttt ttc tca 96 Leu Ser Asp Ser Arg Lys Ile Gln Leu Leu Leu Phe Leu Phe Phe Ser 20 25 30 gtg ttc tat gtg tca agc ctg atg gga aat ctc ctc att gtg cta act 144 Val Phe Tyr Val Ser Ser Leu Met Gly Asn Leu Leu Ile Val Leu Thr 35 40 45 gtg acc tct gac cct cgt tta cag tcc ccc atg tac ttc ctg ctg gcc 192 Val Thr Ser Asp Pro Arg Leu Gln Ser Pro Met Tyr Phe Leu Leu Ala 50 55 60 aac ctt tcc atc atc aat ttg gta ttt tgt tcc tcc aca gct ccc aag 240 Asn Leu Ser Ile Ile Asn Leu Val Phe Cys Ser Ser Thr Ala Pro Lys 65 70 75 80 atg att tat gac ctt ttc agg aag cac aag acc atc tct ttt ggg ggc 288 Met Ile Tyr Asp Leu Phe Arg Lys His Lys Thr Ile Ser Phe Gly Gly 85 90 95 tgt gta gtt cag atc ttc ttt atc cat gca gtt ggg gga act gag atg 336 Cys Val Val Gln Ile Phe Phe Ile His Ala Val Gly Gly Thr Glu Met 100 105 110 gtg ctg ctc ata gcc atg gct ttt gac cga tat gtg gcc ata tgt aag 384 Val Leu Leu Ile Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Lys 115 120 125 cct ctc cac tac ctg acc atc atg aac cca caa agg tgc att ttg ttt 432 Pro Leu His Tyr Leu Thr Ile Met Asn Pro Gln Arg Cys Ile Leu Phe 130 135 140 tta gtc att tcc tgg att ata ggt att att cac tca gtg att cag ttg 480 Leu Val Ile Ser Trp Ile Ile Gly Ile Ile His Ser Val Ile Gln Leu 145 150 155 160 gct ttt gtt gta gac ctg ctg ttc tgt ggc cct aat gaa tta gat agt 528 Ala Phe Val Val Asp Leu Leu Phe Cys Gly Pro Asn Glu Leu Asp Ser 165 170 175 ttc ttt tgt gat ctt cct cga ttt atc aaa ctg gct tgc ata gag acc 576 Phe Phe Cys Asp Leu Pro Arg Phe Ile Lys Leu Ala Cys Ile Glu Thr 180 185 190 tac aca ttg gga ttc atg gtt act gcc aat agt gga ttt att tct ctg 624 Tyr Thr Leu Gly Phe Met Val Thr Ala Asn Ser Gly Phe Ile Ser Leu 195 200 205 gct tct ttt tta att ctc ata atc tct tac atc ttt att ttg gtg act 672 Ala Ser Phe Leu Ile Leu Ile Ile Ser Tyr Ile Phe Ile Leu Val Thr 210 215 220 gtt cag aaa aaa tct tca ggt ggt ata ttc aag gct ttc tct atg ctg 720 Val Gln Lys Lys Ser Ser Gly Gly Ile Phe Lys Ala Phe Ser Met Leu 225 230 235 240 tca gct cat gtc att gtg gtg gtt ttg gtc ttt ggg cca tta atc ttt 768 Ser Ala His Val Ile Val Val Val Leu Val Phe Gly Pro Leu Ile Phe 245 250 255 ttc tat att ttt cca ttt ccc aca tca cat ctt gat aaa ttc ctt gcc 816 Phe Tyr Ile Phe Pro Phe Pro Thr Ser His Leu Asp Lys Phe Leu Ala 260 265 270 atc ttt gat gca gtt atc act ccc gtt ttg aat cca gtc atc tat act 864 Ile Phe Asp Ala Val Ile Thr Pro Val Leu Asn Pro Val Ile Tyr Thr 275 280 285 ttt aga aat aaa gag atg atg gtg gca atg aga aga cga tgc tct cag 912 Phe Arg Asn Lys Glu Met Met Val Ala Met Arg Arg Arg Cys Ser Gln 290 295 300 ttt gtg aat tac agt aaa atc ttt taa 939 Phe Val Asn Tyr Ser Lys Ile Phe 305 310 <210> 128 <211> 312 <212> PRT <213> Homo sapiens <400> 128 Met Asp Glu Ala Asn His Ser Val Val Ser Glu Phe Val Phe Leu Gly 1 5 10 15 Leu Ser Asp Ser Arg Lys Ile Gln Leu Leu Leu Phe Leu Phe Phe Ser 20 25 30 Val Phe Tyr Val Ser Ser Leu Met Gly Asn Leu Leu Ile Val Leu Thr 35 40 45 Val Thr Ser Asp Pro Arg Leu Gln Ser Pro Met Tyr Phe Leu Leu Ala 50 55 60 Asn Leu Ser Ile Ile Asn Leu Val Phe Cys Ser Ser Thr Ala Pro Lys 65 70 75 80 Met Ile Tyr Asp Leu Phe Arg Lys His Lys Thr Ile Ser Phe Gly Gly 85 90 95 Cys Val Val Gln Ile Phe Phe Ile His Ala Val Gly Gly Thr Glu Met 100 105 110 Val Leu Leu Ile Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Lys 115 120 125 Pro Leu His Tyr Leu Thr Ile Met Asn Pro Gln Arg Cys Ile Leu Phe 130 135 140 Leu Val Ile Ser Trp Ile Ile Gly Ile Ile His Ser Val Ile Gln Leu 145 150 155 160 Ala Phe Val Val Asp Leu Leu Phe Cys Gly Pro Asn Glu Leu Asp Ser 165 170 175 Phe Phe Cys Asp Leu Pro Arg Phe Ile Lys Leu Ala Cys Ile Glu Thr 180 185 190 Tyr Thr Leu Gly Phe Met Val Thr Ala Asn Ser Gly Phe Ile Ser Leu 195 200 205 Ala Ser Phe Leu Ile Leu Ile Ile Ser Tyr Ile Phe Ile Leu Val Thr 210 215 220 Val Gln Lys Lys Ser Ser Gly Gly Ile Phe Lys Ala Phe Ser Met Leu 225 230 235 240 Ser Ala His Val Ile Val Val Val Leu Val Phe Gly Pro Leu Ile Phe 245 250 255 Phe Tyr Ile Phe Pro Phe Pro Thr Ser His Leu Asp Lys Phe Leu Ala 260 265 270 Ile Phe Asp Ala Val Ile Thr Pro Val Leu Asn Pro Val Ile Tyr Thr 275 280 285 Phe Arg Asn Lys Glu Met Met Val Ala Met Arg Arg Arg Cys Ser Gln 290 295 300 Phe Val Asn Tyr Ser Lys Ile Phe 305 310 <210> 129 <211> 939 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(939) <400> 129 atg tct gtt ctc aat aac tcc gaa gtc aag ctt ttc ctt ctg att ggg 48 Met Ser Val Leu Asn Asn Ser Glu Val Lys Leu Phe Leu Leu Ile Gly 1 5 10 15 atc cca gga ctg gaa cat gcc cac att tgg ttc tcc atc ccc att tgc 96 Ile Pro Gly Leu Glu His Ala His Ile Trp Phe Ser Ile Pro Ile Cys 20 25 30 ctc atg tac ctg ctt gcc atc atg ggc aac tgc acc att ctc ttt att 144 Leu Met Tyr Leu Leu Ala Ile Met Gly Asn Cys Thr Ile Leu Phe Ile 35 40 45 ata aag aca gag ccc tcg ctt cat gag ccc atg tat tat ttc ctt gcc 192 Ile Lys Thr Glu Pro Ser Leu His Glu Pro Met Tyr Tyr Phe Leu Ala 50 55 60 atg ttg gct gtc tct gac atg ggc ctg tcc ctc tcc tcc ctt cct acc 240 Met Leu Ala Val Ser Asp Met Gly Leu Ser Leu Ser Ser Leu Pro Thr 65 70 75 80 atg ttg agg gtc ttc ttg ttc aat gcc atg gga att tca cct aat gcc 288 Met Leu Arg Val Phe Leu Phe Asn Ala Met Gly Ile Ser Pro Asn Ala 85 90 95 tgc ttt gct caa gaa ttc ttc att cat gga ttc act gtc atg gaa tcc 336 Cys Phe Ala Gln Glu Phe Phe Ile His Gly Phe Thr Val Met Glu Ser 100 105 110 tca gta ctt cta att atg tct ttg gac cgc ttt ctt gcc att cac aat 384 Ser Val Leu Leu Ile Met Ser Leu Asp Arg Phe Leu Ala Ile His Asn 115 120 125 ccc tta aga tac agt tct atc ctc act agc aac agg gtt gct aaa atg 432 Pro Leu Arg Tyr Ser Ser Ile Leu Thr Ser Asn Arg Val Ala Lys Met 130 135 140 gga ctt att tta gcc att agg agc att ctc tta gtg att cca ttt ccc 480 Gly Leu Ile Leu Ala Ile Arg Ser Ile Leu Leu Val Ile Pro Phe Pro 145 150 155 160 ttc acc tta agg aga tta aaa tat tgt caa aag aat ctt ctt tct cac 528 Phe Thr Leu Arg Arg Leu Lys Tyr Cys Gln Lys Asn Leu Leu Ser His 165 170 175 tca tac tgt ctt cat cag gat acc atg aag ctg gcc tgc tct gac aac 576 Ser Tyr Cys Leu His Gln Asp Thr Met Lys Leu Ala Cys Ser Asp Asn 180 185 190 aag acc aat gtc atc tat ggc ttc ttc att gct ctc tgt act atg ctg 624 Lys Thr Asn Val Ile Tyr Gly Phe Phe Ile Ala Leu Cys Thr Met Leu 195 200 205 gac ttg gca ctg att gtt ttg tct tat gtg ctg atc ttg aag act ata 672 Asp Leu Ala Leu Ile Val Leu Ser Tyr Val Leu Ile Leu Lys Thr Ile 210 215 220 ctc agc att gca tct ttg gca gag agg ctt aag gcc cta aat acc tgt 720 Leu Ser Ile Ala Ser Leu Ala Glu Arg Leu Lys Ala Leu Asn Thr Cys 225 230 235 240 gtc tcc cac atc tgt gct gtg ctc acc ttc tat gtg ccc atc atc acc 768 Val Ser His Ile Cys Ala Val Leu Thr Phe Tyr Val Pro Ile Ile Thr 245 250 255 ctg gct gcc atg cat cac ttt gcc aag cac aaa agc cct ctt gtt gtg 816 Leu Ala Ala Met His His Phe Ala Lys His Lys Ser Pro Leu Val Val 260 265 270 atc ctt att gca gat atg ttc ttg ttg gtg ccg ccc ctt atg aac ccc 864 Ile Leu Ile Ala Asp Met Phe Leu Leu Val Pro Pro Leu Met Asn Pro 275 280 285 att gtg tac tgt gta aag act cga caa atc tgg gag aag atc ttg ggg 912 Ile Val Tyr Cys Val Lys Thr Arg Gln Ile Trp Glu Lys Ile Leu Gly 290 295 300 aag ttg ctt aat gta tgt ggg aga taa 939 Lys Leu Leu Asn Val Cys Gly Arg 305 310 <2 10> 130 <211> 312 <212> PRT <213> Homo sapiens <400> 130 Met Ser Val Leu Asn Asn Ser Glu Val Lys Leu Phe Leu Leu Ile Gly 1 5 10 15 Ile Pro Gly Leu Glu His Ala His Ile Trp Phe Ser Ile Pro Ile Cys 20 25 30 Leu Met Tyr Leu Leu Ala Ile Met Gly Asn Cys Thr Ile Leu Phe Ile 35 40 45 Ile Lys Thr Glu Pro Ser Leu His Glu Pro Met Tyr Tyr Phe Leu Ala 50 55 60 Met Leu Ala Val Ser Asp Met Gly Leu Ser Leu Ser Ser Leu Pro Thr 65 70 75 80 Met Leu Arg Val Phe Leu Phe Asn Ala Met Gly Ile Ser Pro Asn Ala 85 90 95 Cys Phe Ala Gln Glu Phe Phe Ile His Gly Phe Thr Val Met Glu Ser 100 105 110 Ser Val Leu Leu Ile Met Ser Leu Asp Arg Phe Leu Ala Ile His Asn 115 120 125 Pro Leu Arg Tyr Ser Ser Ile Leu Thr Ser Asn Arg Val Ala Lys Met 130 135 140 Gly Leu Ile Leu Ala Ile Arg Ser Ile Leu Leu Val Ile Pro Phe Pro 145 150 155 160 Phe Thr Leu Arg Arg Leu Lys Tyr Cys Gln Lys Asn Leu Leu Ser His 165 170 175 Ser Tyr Cys Leu His Gln Asp Thr Met Lys Leu Ala Cys Ser Asp Asn 180 185 190 Lys Thr Asn Val Ile Tyr Gly Phe Phe Ile Ala Leu Cys Thr Met Leu 195 200 205 Asp Leu Ala Leu Ile Val Leu Ser Tyr Val Leu Ile Leu Lys Thr Ile 210 215 220 Leu Ser Ile Ala Ser Leu Ala Glu Arg Leu Lys Ala Leu Asn Thr Cys 225 230 235 240 Va l Ser His Ile Cys Ala Val Leu Thr Phe Tyr Val Pro Ile Ile Thr 245 250 255 Leu Ala Ala Met His His Phe Ala Lys His Lys Ser Pro Leu Val Val 260 265 270 Ile Leu Ile Ala Asp Met Phe Leu Leu Val Pro Pro Leu Met Asn Pro 275 280 285 Ile Val Tyr Cys Val Lys Thr Arg Gln Ile Trp Glu Lys Ile Leu Gly 290 295 300 Lys Leu Leu Asn Val Cys Gly Arg 305 310 <210> 131 <211> 909 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(909) <400> 131 atg acg aac ttg aat gca tca cag gcc aac cac cgt aac ttc att ctg 48 Met Thr Asn Leu Asn Ala Ser Gln Ala Asn His Arg Asn Phe Ile Leu 1 5 10 15 aca ggt atc cca gga acg cca gac aag aac cca tgg ttg gcc ttt ccc 96 Thr Gly Ile Pro Gly Thr Pro Asp Lys Asn Pro Trp Leu Ala Phe Pro 20 25 30 ctg gga ttt ctc tac aca ctc aca ctc ctg gga aat ggt acc atc cta 144 Leu Gly Phe Leu Tyr Thr Leu Thr Leu Leu Gly Asn Gly Thr Ile Leu 35 40 45 gct gtc atc aag gtg gag cca agt ctc cat gag ccc acg tat tac ttc 192 Ala Val Ile Lys Val Glu Pro Ser Leu His Glu Pro Thr Tyr Tyr Phe 50 55 60 ctt tct atc ttg gct ctc act gac gtt agt ctc tcc atg tcc acc ttg 240 Leu Ser Ile Leu Ala Leu Thr Asp Val Ser Leu Ser Met Ser Thr Leu 65 70 75 80 ccc tcc atg ctc agc atc tac tgg ttt aat gcc cct cag att gtt ttt 288 Pro Ser Met Leu Ser Ile Tyr Trp Phe Asn Ala Pro Gln Ile Val Phe 85 90 95 gat gca tgc atc atg cag atg ttc ttc atc cat gta ttt gga ata gta 336 Asp Ala Cys Ile Met Gln Met Phe Phe Ile His Val Phe Gly Ile Val 100 105 110 gaa tca gga gtc cta gtg tcc atg gcc ttt gac aga ttt gtg gcc atc 384 Glu Ser Gly Val Leu Val Ser Met Ala Phe Asp Arg Phe Val Ala Ile 115 120 125 cga aac cca tta cac tat gtt tcc atc ctc act cac gat gtt att cga 432 Arg Asn Pro Leu His Tyr Val Ser Ile Leu Thr His Asp Val Ile Arg 130 135 140 aag act gga ata tct gtc ctc acc cgg gca gtc tgt gtg gta ttc cct 480 Lys Thr Gly Ile Ser Val Leu Thr Arg Ala Val Cys Val Val Phe Pro 145 150 155 160 gtg ccc ttc ctt ata aag tgc cta ccc ttc tgc cat tcc aat gtc ttg 528 Val Pro Phe Leu Ile Lys Cys Leu Pro Phe Cys His Ser Asn Val Leu 165 170 175 tct cat tca tac tgt ctt cac caa aac atg atg cgg cta gct tgt gcc 576 Ser His Ser Tyr Cys Leu His Gln Asn Met Met Arg Leu Ala Cys Ala 180 185 190 agc acc cgc atc aac agc ctc tac ggc ctc atc gtc gtc atc ttc aca 624 Ser Thr Arg Ile Asn Ser Leu Tyr Gly Leu Ile Val Val Ile Phe Thr 195 200 205 ctg ggg ctc gat gtt ctc ctc act cta ctg tct tat gta ctc acc ctg 672 Leu Gly Leu Asp Val Leu Leu Thr Leu Leu Ser Tyr Val Leu Thr Leu 210 215 220 aag act gtg ctg ggc att gtc tcc aga ggt gaa agg ctg aaa acc ctc 720 Lys Thr Val Leu Gly Ile Val Ser Arg Gly Glu Arg Leu Lys Thr Leu 225 230 235 240 agc aca tgc ctc tct cac atg tct acc gtg ctc ctc ttc tat gtt cct 768 Ser Thr Cys Leu Ser His Met Ser Thr Val Leu Leu Phe Tyr Val Pro 245 250 255 ttt atg ggt gct gcc tcc atg atc cac aga ttt tgg gag cat tta tca 816 Phe Met Gly Ala Ala Ser Met Ile His Arg Phe Trp Glu His Leu Ser 260 265 270 cca gta gtg cac atg gtc atg gct gat ata tac cta ctg ctc ccg cct 864 Pro Val Val His Met Val Met Ala Asp Ile Tyr Leu Leu Leu Pro Pro 275 280 285 gtg cta aac ccc att gtc tac agt gtg aag acc aag caa att tga 909 Val Leu Asn Pro Ile Val Tyr Ser Val Lys Thr Lys Gln Ile 290 295 300 <210> 132 <211> 302 <212> PRT <213> Homo sapiens <400> 132 Met Thr Asn Leu Asn Ala Ser Gln Ala Asn His Arg Asn Phe Ile Leu 1 5 10 15 Thr Gly Ile Pro Gly Thr Pro Asp Lys Asn Pro Trp Leu Ala Phe Pro 20 25 30 Leu Gly Phe Leu Tyr Thr Leu Thr Leu Leu Gly Asn Gly Thr Ile Leu 35 40 45 Ala Val Ile Lys Val Glu Pro Ser Leu His Glu Pro Thr Tyr Tyr Phe 50 55 60 Leu Ser Ile Leu Ala Leu Thr Asp Val Ser Leu Ser Met Ser Thr Leu 65 70 75 80 Pro Ser Met Leu Ser Ile Tyr Trp Phe Asn Ala Pro Gln Ile Val Phe 85 90 95 Asp Ala Cys Ile Met Gln Met Phe Phe Ile His Val Phe Gly Ile Val 100 105 110 Glu Ser Gly Val Leu Val Ser Met Ala Phe Asp Arg Phe Val Ala Ile 115 120 125 Arg Asn Pro Leu His Tyr Val Ser Ile Leu Thr His Asp Val Ile Arg 130 135 140 Lys Thr Gly Ile Ser Val Leu Thr Arg Ala Val Cys Val Val Phe Pro 145 150 155 160 Val Pro Phe Leu Ile Lys Cys Leu Pro Phe Cys His Ser Asn Val Leu 165 170 175 Ser His Ser Tyr Cys Leu His Gln Asn Met Met Arg Leu Ala Cys Ala 180 185 190 Ser Thr Arg Ile Asn Ser Leu Tyr Gly Leu Ile Val Val Ile Phe Thr 195 200 205 Leu Gly Leu Asp Val Leu Leu Thr Leu Leu Ser Tyr Val Leu Thr Leu 210 215 220 Lys Thr Val Leu Gly Ile Val Ser Arg Gly Glu Arg Leu Lys Thr Leu 225 230 235 240 Ser Thr Cys Leu Ser His Met Ser Thr Val Leu Leu Phe Tyr Val Pro 245 250 255 Phe Met Gly Ala Ala Ser Met Ile His Arg Phe Trp Glu His Leu Ser 260 265 270 Pro Val Val His Met Val Met Ala Asp Ile Tyr Leu Leu Leu Pro Pro 275 280 285 Val Leu Asn Pro Ile Val Tyr Ser Val Lys Thr Lys Gln Ile 290 295 300 <2 10> 133 <211> 765 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(765) <400> 133 atg tac ctc ttt ctg gcc atg ctg gcc atc act gac ctg gtc ctc tcc 48 Met Tyr Leu Phe Leu Ala Met Leu Ala Ile Thr Asp Leu Val Leu Ser 1 5 10 15 tcc tcc act caa cct aag atg ttg gcc ata ttc tgg ttt cat gct cat 96 Ser Ser Thr Gln Pro Lys Met Leu Ala Ile Phe Trp Phe His Ala His 20 25 30 gag att cag tac cat gcc tgc ctc atc cag gtg ttc ttc atc cat gcc 144 Glu Ile Gln Tyr His Ala Cys Leu Ile Gln Val Phe Phe Ile His Ala 35 40 45 ttt tct tct gtg gag tct ggg gtg ctc atg gct atg gcc ctg gac tgc 192 Phe Ser Ser Val Glu Ser Gly Val Leu Met Ala Met Ala Leu Asp Cys 50 55 60 tac gtg gct acc tgc ttc cca ctc cga cac tct agc atc ctg acc cca 240 Tyr Val Ala Thr Cys Phe Pro Leu Arg His Ser Ser Ile Leu Thr Pro 65 70 75 80 tcg gtc gtg atc aaa ctg ggg acc atc gtg atg ctg aga ggg ctg ctg 288 Ser Val Val Ile Lys Leu Gly Thr Ile Val Met Leu Arg Gly Leu Leu 85 90 95 tgg gtg agc ccc ttc tgc ttc atg gtg tct agg atg ccc ttc tgc caa 336 Trp Val Ser Pro Phe Cys Phe Met Val Ser Arg Met Pro Phe Cys Gln 100 105 110 cac caa gcc att ccc cag tca tac tgt gag cac atg gct gtg ctg aag 384 His Gln Ala Ile Pro Gln Ser Tyr Cys Glu His Met Ala Val Leu Lys 115 120 125 ttg gtg tgt gct gat aca agc ata agt cgt ggg tat ggg ctc ttt gtg 432 Leu Val Cys Ala Asp Thr Ser Ile Ser Arg Gly Tyr Gly Leu Phe Val 130 135 140 gcc ttc tct gtg gct ggc ttt gat atg att gtc att ggt atg tca tac 480 Ala Phe Ser Val Ala Gly Phe Asp Met Ile Val Ile Gly Met Ser Tyr 145 150 155 160 gtg atg att ttg aga gct gtg ctt cag ttg ccc tca ggt gaa gcc cgc 528 Val Met Ile Leu Arg Ala Val Leu Gln Leu Pro Ser Gly Glu Ala Arg 165 170 175 ctc aaa gct ttt agc aca cgt gcc tcc cat atc tgt gtc atc ttg gct 576 Leu Lys Ala Phe Ser Thr Arg Ala Ser His Ile Cys Val Ile Leu Ala 180 185 190 ctt tat atc cca gcc ctt ttt tct ttc ctc acc tac cgc ttt ggc cat 624 Leu Tyr Ile Pro Ala Leu Phe Ser Phe Leu Thr Tyr Arg Phe Gly His 195 200 205 gat gtg ccc cga gtt gta cac atc ctg ttt gct aat ctc tat cta ctg 672 Asp Val Pro Arg Val Val His Ile Leu Phe Ala Asn Leu Tyr Leu Leu 210 215 220 ata cct ccc atg ctc aac ccc atc att tat gga gtt aga acc aaa cag 720 Ile Pro Pro Met Leu Asn Pro Ile Ile Tyr Gly Val Arg Thr Lys Gln 225 230 235 240 atc ggg gac agg gtt atc caa gga tgt tgt gga aac atc ccc tga 765 Ile Gly Asp Arg Val Ile Gln Gly Cys Cys Gly Asn Ile Pro 245 250 255 <210> 134 <211> 254 <212> PRT <213> Homo sapiens <400> 134 Met Tyr Leu Phe Leu Ala Met Leu Ala Ile Thr Asp Leu Val Leu Ser 1 5 10 15 Ser Ser Thr Gln Pro Lys Met Leu Ala Ile Phe Trp Phe His Ala His 20 25 30 Glu Ile Gln Tyr His Ala Cys Leu Ile Gln Val Phe Phe Ile His Ala 35 40 45 Phe Ser Ser Val Glu Ser Gly Val Leu Met Ala Met Ala Leu Asp Cys 50 55 60 Tyr Val Ala Thr Cys Phe Pro Leu Arg His Ser Ser Ile Leu Thr Pro 65 70 75 80 Ser Val Val Ile Lys Leu Gly Thr Ile Val Met Leu Arg Gly Leu Leu 85 90 95 Trp Val Ser Pro Phe Cys Phe Met Val Ser Arg Met Pro Phe Cys Gln 100 105 110 His Gln Ala Ile Pro Gln Ser Tyr Cys Glu His Met Ala Val Leu Lys 115 120 125 Leu Val Cys Ala Asp Thr Ser Ile Ser Arg Gly Tyr Gly Leu Phe Val 130 135 140 Ala Phe Ser Val Ala Gly Phe Asp Met Ile Val Ile Gly Met Ser Tyr 145 150 155 160 Val Met Ile Leu Arg Ala Val Leu Gln Leu Pro Ser Gly Glu Ala Arg 165 170 175 Leu Lys Ala Phe Ser Thr Arg Ala Ser His Ile Cys Val Ile Leu Ala 180 185 190 Leu Tyr Ile Pro Ala Leu Phe Ser Phe Leu Thr Tyr Arg Phe Gly His 195 200 205 Asp Val Pro Arg Val Val His Ile Leu Phe Ala Asn Leu Tyr Leu Leu 210 215 220 Ile Pro Pro Met Leu Asn Pro Ile Ile Tyr Gly Val Arg Thr Lys Gln 225 230 235 240 Ile Gly Asp Arg Val Ile Gln Gly Cys Cys Gly Asn Ile Pro 245 250 <210> 135 <211> 972 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(972) <400> 135 atg tca aca tta cca act cag ata gcc ccc aat agc agc act tca atg 48 Met Ser Thr Leu Pro Thr Gln Ile Ala Pro Asn Ser Ser Thr Ser Met 1 5 10 15 gcc ccc acc ttc ttg ctg gtg ggc atg cca ggc cta tca ggt gca ccc 96 Ala Pro Thr Phe Leu Leu Val Gly Met Pro Gly Leu Ser Gly Ala Pro 20 25 30 tcc tgg tgg aca ttg ccc ctc att gct gtc tac ctt ctc tct gca ctg 144 Ser Trp Trp Thr Leu Pro Leu Ile Ala Val Tyr Leu Leu Ser Ala Leu 35 40 45 gga aat ggc acc atc ctc tgg atc att gcc ctg cag ccc gcc ctg cac 192 Gly Asn Gly Thr Ile Leu Trp Ile Ile Ala Leu Gln Pro Ala Leu His 50 55 60 cgc cca atg cac ttc ttc ctc ttc ttg ctt agt gtg tct gat att gga 240 Arg Pro Met His Phe Phe Leu Phe Leu Leu Ser Val Ser Asp Ile Gly 65 70 75 80 ttg gtc act gcc ctg atg ccc aca ctg ctg ggc atc gcc ctt gct ggt 288 Leu Val Thr Ala Leu Met Pro Thr Leu Leu Gly Ile Ala Leu Ala Gly 85 90 95 gct cac act gtc cct gcc tca gcc tgc ctt cta cag atg gtt ttt atc 336 Ala His Thr Val Pro Ala Ser Ala Cys Leu Leu Gln Met Val Phe Ile 100 105 110 cat gtc ttt tct gtc atg gag tcc tct gtc ttg ctc gcc atg tcc att 384 His Val Phe Ser Val Met Glu Ser Ser Val Leu Leu Ala Met Ser Ile 115 120 125 gat cgg gca ctg gcc atc tgc cga cct ctc cac tac cca gcg ctc ctc 432 Asp Arg Ala Leu Ala Ile Cys Arg Pro Leu His Tyr Pro Ala Leu Leu 130 135 140 acc aat ggt gta att agc aaa atc agc ctg gcc att tct ttt cga tgc 480 Thr Asn Gly Val Ile Ser Lys Ile Ser Leu Ala Ile Ser Phe Arg Cys 145 150 155 160 ctg ggt ctc cat ctg ccc ctg cca ttc ctg ctg gcc tac atg ccc tac 528 Leu Gly Leu His Leu Pro Leu Pro Phe Leu Leu Ala Tyr Met Pro Tyr 165 170 175 tgc ctc cca cag gtc cta acc cat tct tat tgc ttg cat cca gat gtg 576 Cys Leu Pro Gln Val Leu Thr His Ser Tyr Cys Leu His Pro Asp Val 180 185 190 gct cgt ttg gcc tgc cca gaa gct tgg ggt gca gcc tac agc cta ttt 624 Ala Arg Leu Ala Cys Pro Glu Ala Trp Gly Ala Ala Tyr Ser Leu Phe 195 200 205 gtg gtt ctt tca gcc atg ggt ttg gac ccc ctg ctt att ttc ttc tcc 672 Val Val Leu Ser Ala Met Gly Leu Asp Pro Leu Leu Ile Phe Phe Ser 210 215 220 tat ggc ctg att ggc aag gtg ttg caa ggt gtg gag tcc aga gag gat 720 Tyr Gly Leu Ile Gly Lys Val Leu Gln Gly Val Glu Ser Arg Glu Asp 225 230 235 240 cgc tgg aag gct ggt caa acc tgt gct gcc cac ctc tct gca gtg ctc 768 Arg Trp Lys Ala Gly Gln Thr Cys Ala Ala His Leu Ser Ala Val Leu 245 250 255 ctc ttc tat atc cct atg atc ctc ctg gca ctg att aac cat cct gag 816 Leu Phe Tyr Ile Pro Met Ile Leu Leu Ala Leu Ile Asn His Pro Glu 260 265 270 ctg cca atc act cag cat acc cat act ctt cta tcc tat gtc cat ttc 864 Leu Pro Ile Thr Gln His Thr His Thr Leu Leu Ser Tyr Val His Phe 275 280 285 ctt ctt cct cca ttg ata aac cct att ctc tat agt gtc aag atg aag 912 Leu Leu Pro Pro Leu Ile Asn Pro Ile Leu Tyr Ser Val Lys Met Lys 290 295 300 gag att aga aag aga ata ctc aac agg ttg cag ccc agg aag gtg ggt 960 Glu Ile Arg Lys Arg Ile Leu Asn Arg Leu Gln Pro Arg Lys Val Gly 305 310 315 320 ggt gct cag tga 972 Gly Ala Gln < 210> 136 <211> 323 <212> PRT <213> Homo sapiens <400> 136 Met Ser Thr Leu Pro Thr Gln Ile Ala Pro Asn Ser Ser Thr Ser Met 1 5 10 15 Ala Pro Thr Phe Leu Leu Val Gly Met Pro Gly Leu Ser Gly Ala Pro 20 25 30 Ser Trp Trp Thr Leu Pro Leu Ile Ala Val Tyr Leu Leu Ser Ala Leu 35 40 45 Gly Asn Gly Thr Ile Leu Trp Ile Ile Ala Leu Gln Pro Ala Leu His 50 55 60 Arg Pro Met His Phe Phe Leu Phe Leu Leu Ser Val Ser Asp Ile Gly 65 70 75 80 Leu Val Thr Ala Leu Met Pro Thr Leu Leu Gly Ile Ala Leu Ala Gly 85 90 95 Ala His Thr Val Pro Ala Ser Ala Cys Leu Leu Gln Met Val Phe Ile 100 105 110 His Val Phe Ser Val Met Glu Ser Ser Val Leu Leu Ala Met Ser Ile 115 120 125 Asp Arg Ala Leu Ala Ile Cys Arg Pro Leu His Tyr Pro Ala Leu Leu 130 135 140 Thr Asn Gly Val Ile Ser Lys Ile Ser Leu Ala Ile Ser Phe Arg Cys 145 150 155 160 Leu Gly Leu His Leu Pro Leu Pro Phe Leu Leu Ala Tyr Met Pro Tyr 165 170 175 Cys Leu Pro Gln Val Leu Thr His Ser Tyr Cys Leu His Pro Asp Val 180 185 190 Ala Arg Leu Ala Cys Pro Glu Ala Trp Gly Ala Ala Tyr Ser Leu Phe 195 200 205 Val Val Leu Ser Ala Met Gly Leu Asp Pro Leu Leu Ile Phe Phe Ser 210 215 220 Tyr Gly Leu Ile Gly Lys Val Leu Gln Gly Val Glu Ser Arg Glu Asp 225 230 235 240 A rg Trp Lys Ala Gly Gln Thr Cys Ala Ala His Leu Ser Ala Val Leu 245 250 255 Leu Phe Tyr Ile Pro Met Ile Leu Leu Ala Leu Ile Asn His Pro Glu 260 265 270 Leu Pro Ile Thr Gln His Thr His Thr Leu Leu Ser Tyr Val His Phe 275 280 285 Leu Leu Pro Pro Leu Ile Asn Pro Ile Leu Tyr Ser Val Lys Met Lys 290 295 300 Glu Ile Arg Lys Arg Ile Leu Asn Arg Leu Gln Pro Arg Lys Val Gly 305 310 315 320 Gly Ala Gln <210> 137 <211> 1065 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1065) <400> 137 atg act aat aaa atg tat gct ata tat ata aag aat ctt aat tat ttt 48 Met Thr Asn Lys Met Tyr Ala Ile Tyr Ile Lys Asn Leu Asn Tyr Phe 1 5 10 15 tct ttc ctc ata gtt cag tgt ctt caa cca acc atg gca ata ttc aat 96 Ser Phe Leu Ile Val Gln Cys Leu Gln Pro Thr Met Ala Ile Phe Asn 20 25 30 aac acc act tcg tct tcc tca aac ttc ctc ctc act gca ttc cct ggg 144 Asn Thr Thr Ser Ser Ser Ser Asn Phe Leu Leu Thr Ala Phe Pro Gly 35 40 45 ctg gaa tgt gct cat gtc tgg atc tcc att cca gtc tgc tgt ctc tac 192 Leu Glu Cys Ala His Val Trp Ile Ser Ile Pro Val Cys Cys Leu Tyr 50 55 60 acc att gcc ctc ttg gga aac agt atg atc ttt ctt gtc atc att act 240 Thr Ile Ala Leu Leu Gly Asn Ser Met Ile Phe Leu Val Ile Ile Thr 65 70 75 80 aag cgg aga ctc cac aaa ccc atg tat tat ttc ctc tcc atg ctg gca 288 Lys Arg Arg Leu His Lys Pro Met Tyr Tyr Phe Leu Ser Met Leu Ala 85 90 95 gct gtt gat cta tgt ctg acc att acg acc ctt ccc act gtg ctt ggt 336 Ala Val Asp Leu Cys Leu Thr Ile Thr Thr Leu Pro Thr Val Leu Gly 100 105 110 gtt ctc tgg ttt cat gcc cgg gag atc agc ttt aaa gct tgc ttc att 384 Val Leu Trp Phe His Ala Arg Glu Ile Ser Phe Lys Ala Cys Phe Ile 115 120 125 caa atg ttc ttt gtg cat gct ttc tcc ttg ctg gag tcc tcg gtg ctg 432 Gln Met Phe Phe Val His Ala Phe Ser Leu Leu Glu Ser Ser Val Leu 130 135 140 gta gcc atg gcc ttt gac cgc ttc gtg gct atc tgt aac cca ctg aac 480 Val Ala Met Ala Phe Asp Arg Phe Val Ala Ile Cys Asn Pro Leu Asn 145 150 155 160 tat gct act atc ctc aca gac agg atg gtc ctg gtg ata ggg ctg gtc 528 Tyr Ala Thr Ile Leu Thr Asp Arg Met Val Leu Val Ile Gly Leu Val 165 170 175 atc tgc att aga cca gca gtt ttc tta ctt ccc ctt ctt gta gcc ata 576 Ile Cys Ile Arg Pro Ala Val Phe Leu Leu Pro Leu Leu Val Ala Ile 180 185 190 aac act gtg tct ttt cat ggg ggt cac gag ctt tcc cat cca ttt tgc 624 Asn Thr Val Ser Phe His Gly Gly His Glu Leu Ser His Pro Phe Cys 195 200 205 tac cac cca gaa gtg atc aaa tac aca tat tcc aaa cct tgg atc agc 672 Tyr His Pro Glu Val Ile Lys Tyr Thr Tyr Ser Lys Pro Trp Ile Ser 210 215 220 agt ttt tgg gga ctg ttt ctt cag ctc tac ctg aat ggc act gac gta 720 Ser Phe Trp Gly Leu Phe Leu Gln Leu Tyr Leu Asn Gly Thr Asp Val 225 230 235 240 ttg ttt att ctt ttc tcc tat gtc ctg atc ctc cgt act gtt ctg ggc 768 Leu Phe Ile Leu Phe Ser Tyr Val Leu Ile Leu Arg Thr Val Leu Gly 245 250 255 att gtg gcc cga aag aag caa caa aaa gct ctc agc act tgt gtc tgt 816 Ile Val Ala Arg Lys Lys Gln Gln Lys Ala Leu Ser Thr Cys Val Cys 260 265 270 cac atc tgt gca gtc act att ttc tat gtg cca ctg atc agc ctc tct 864 His Ile Cys Ala Val Thr Ile Phe Tyr Val Pro Leu Ile Ser Leu Ser 275 280 285 ttg gca cac cgc ctc ttc cac tcc acc cca agg gtg ctc tgt agc act 912 Leu Ala His Arg Leu Phe His Ser Thr Pro Arg Val Leu Cys Ser Thr 290 295 300 ttg gcc aat att tat ctg ctc tta cca cct gtg ctg aac cct atc att 960 Leu Ala Asn Ile Tyr Leu Leu Leu Pro Pro Val Leu Asn Pro Ile Ile 305 310 315 320 tac agc ttg aag acc aag aca atc cgc cag gct atg ttc cag ctg ctc 1008 Tyr Ser Leu Lys Thr Lys Thr Ile Arg Gln Ala Met Phe Gln Leu Leu 325 330 335 caa tcc aag ggt tca tgg ggt ttt aat gtg agg ggt ctt agg gga aga 1056 Gln Ser Lys Gly Ser Trp Gly Phe Asn Val Arg Gly Leu Arg Gly Arg 340 345 350 tgg gat tga 1065 Trp Asp 355 <210> 138 <211> 354 <212> PRT <213> Homo sapiens <400> 138 Met Thr Asn Lys Met Tyr Ala Ile Tyr Ile Lys Asn Leu Asn Tyr Phe 1 5 10 15 Ser Phe Leu Ile Val Gln Cys Leu Gln Pro Thr Met Ala Ile Phe Asn 20 25 30 Asn Thr Thr Ser Ser Ser Ser Asn Phe Leu Leu Thr Ala Phe Pro Gly 35 40 45 Leu Glu Cys Ala His Val Trp Ile Ser Ile Pro Val Cys Cys Leu Tyr 50 55 60 Thr Ile Ala Leu Leu Gly Asn Ser Met Ile Phe Leu Val Ile Ile Thr 65 70 75 80 Lys Arg Arg Leu His Lys Pro Met Tyr Tyr Phe Leu Ser Met Leu Ala 85 90 95 Ala Val Asp Leu Cys Leu Thr Ile Thr Thr Leu Pro Thr Val Leu Gly 100 105 110 Val Leu Trp Phe His Ala Arg Glu Ile Ser Phe Lys Ala Cys Phe Ile 115 120 125 Gln Met Phe Phe Val His Ala Phe Ser Leu Leu Glu Ser Ser Val Leu 130 135 140 Val Ala Met Ala Phe Asp Arg Phe Val Ala Ile Cys Asn Pro Leu Asn 145 150 155 160 Tyr Ala Thr Ile Leu Thr Asp Arg Met Val Leu Val Ile Gly Leu Val 165 170 175 Ile Cys Ile Arg Pro Ala Val Phe Leu Leu Pro Leu Leu Val Ala Ile 180 185 190 Asn Thr Val Ser Phe His Gly Gly His Glu Leu Ser His Pro Phe Cys 195 200 205 Tyr His Pro Glu Val Ile Lys Tyr Thr Tyr Ser Lys Pro Trp Ile Ser 210 215 220 Ser Phe Trp Gly Leu Phe Leu Gln Leu Tyr Leu Asn Gly Thr Asp Val 225 230 235 240 Leu Phe Ile Leu Phe Ser Tyr Val Leu Ile Leu Arg Thr Val Leu Gly 245 250 255 Ile Val Ala Arg Lys Lys Gln Gln Lys Ala Leu Ser Thr Cys Val Cys 260 265 270 His Ile Cys Ala Val Thr Ile Phe Tyr Val Pro Leu Ile Ser Leu Ser 275 280 285 Leu Ala His Arg Leu Phe His Ser Thr Pro Arg Val Leu Cys Ser Thr 290 295 300 Leu Ala Asn Ile Tyr Leu Leu Leu Pro Pro Val Leu Asn Pro Ile Ile 305 310 315 320 Tyr Ser Leu Lys Thr Lys Thr Ile Arg Gln Ala Met Phe Gln Leu Leu 325 330 335 Gln Ser Lys Gly Ser Trp Gly Phe Asn Val Arg Gly Leu Arg Gly Arg 340 345 350 Trp Asp <210> 139 <211> 942 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(942) <400> 139 atg tcc att atc aac aca tca tat gtt gaa atc acc acc ttc ttc ttg 48 Met Ser Ile Ile Asn Thr Ser Tyr Val Glu Ile Thr Thr Phe Phe Leu 1 5 10 15 gtt ggg atg cca ggg cta gaa tat gca cac atc tgg atc tct atc ccc 96 Val Gly Met Pro Gly Leu Glu Tyr Ala His Ile Trp Ile Ser Ile Pro 20 25 30 atc tgc agc atg tat ctt att gct att cta gga aat tgc acc att ctt 144 Ile Cys Ser Met Tyr Leu Ile Ala Ile Leu Gly Asn Cys Thr Ile Leu 35 40 45 ttt atc atc aag aca gag ccc tcc ttg cat gag ccc atg tac tat ttt 192 Phe Ile Ile Lys Thr Glu Pro Ser Leu His Glu Pro Met Tyr Tyr Phe 50 55 60 ctt tcc atg ttg gct atg tca gac ttg ggt ttg tct tta tca tct ctg 240 Leu Ser Met Leu Ala Met Ser Asp Leu Gly Leu Ser Leu Ser Ser Leu 65 70 75 80 ccc act gtg tta agc atc ttc ctg ttc aat gct cct gaa att tca tcc 288 Pro Thr Val Leu Ser Ile Phe Leu Phe Asn Ala Pro Glu Ile Ser Ser 85 90 95 aat gcc tgc ttt gcc cag gaa ttc ttc att cat gga ttc tca gta ctg 336 Asn Ala Cys Phe Ala Gln Glu Phe Phe Ile His Gly Phe Ser Val Leu 100 105 110 gag tcc tca gtc ctc ctg atc atg tca ttt gat aga ttc cta gcc atc 384 Glu Ser Ser Val Leu Leu Ile Met Ser Phe Asp Arg Phe Leu Ala Ile 115 120 125 cac aac cct ctg aga tac acc tca atc ctg aca act gtc aga gtt gcc 432 His Asn Pro Leu Arg Tyr Thr Ser Ile Leu Thr Thr Val Arg Val Ala 130 135 140 caa ata ggg ata gta ttc tcc ttt aag agc atg ctc ctg gtt ctt ccc 480 Gln Ile Gly Ile Val Phe Ser Phe Lys Ser Met Leu Leu Val Leu Pro 145 150 155 160 ttc cct ttc act tta aga aac ttg aga tat tgc aag aaa aac caa tta 528 Phe Pro Phe Thr Leu Arg Asn Leu Arg Tyr Cys Lys Lys Asn Gln Leu 165 170 175 tcc cat tcc tac tgt ctc cac cag gat gtc atg aag ttg gcc tgt tct 576 Ser His Ser Tyr Cys Leu His Gln Asp Val Met Lys Leu Ala Cys Ser 180 185 190 gac aac aga att gat gtt atc tat ggc ttt ttt gga gca ctc tgc ctt 624 Asp Asn Arg Ile Asp Val Ile Tyr Gly Phe Phe Gly Ala Leu Cys Leu 195 200 205 atg gta gac ttt att ctc att gct gtg tct tac acc ctg atc ctc aag 672 Met Val Asp Phe Ile Leu Ile Ala Val Ser Tyr Thr Leu Ile Leu Lys 210 215 220 act gta ccg gga att gca tcc aaa aag gag cag ctt aag gct ctc aat 720 Thr Val Pro Gly Ile Ala Ser Lys Lys Glu Gln Leu Lys Ala Leu Asn 225 230 235 240 act tgt gtt tca cac atc tgt gca gtg atc atc ttc tac ctg ccc atc 768 Thr Cys Val Ser His Ile Cys Ala Val Ile Ile Phe Tyr Leu Pro Ile 245 250 255 atc aac ctg gcc gtt gtc cac cgc ttt gcc cgg cat gtc tct ccc ctc 816 Ile Asn Leu Ala Val Val His Arg Phe Ala Arg His Val Ser Pro Leu 260 265 270 att aat gtt ctc atg gca aat gtt ctc cta ctt gta cct cca ctg atg 864 Ile Asn Val Leu Met Ala Asn Val Leu Leu Leu Val Pro Pro Leu Met 275 280 285 aac cca att gtt tat tgt gta aaa act aaa cag att aga gtg aga gtt 912 Asn Pro Ile Val Tyr Cys Val Lys Thr Lys Gln Ile Arg Val Arg Val 290 295 300 gta gca aaa ttg tgt caa cgg aag att taa 942 Val Ala Lys Leu Cys Gln Arg Lys Ile 305 310 <210> 140 <211> 313 <212> PRT <213> Homo sapiens <400> 140 Met Ser Ile Ile Asn Thr Ser Tyr Val Glu Ile Thr Thr Phe Phe Leu 1 5 10 15 Val Gly Met Pro Gly Leu Glu Tyr Ala His Ile Trp Ile Ser Ile Pro 20 25 30 Ile Cys Ser Met Tyr Leu Ile Ala Ile Leu Gly Asn Cys Thr Ile Leu 35 40 45 Phe Ile Ile Lys Thr Glu Pro Ser Leu His Glu Pro Met Tyr Tyr Phe 50 55 60 Leu Ser Met Leu Ala Met Ser Asp Leu Gly Leu Ser Leu Ser Ser Leu 65 70 75 80 Pro Thr Val Leu Ser Ile Phe Leu Phe Asn Ala Pro Glu Ile Ser Ser 85 90 95 Asn Ala Cys Phe Ala Gln Glu Phe Phe Ile His Gly Phe Ser Val Leu 100 105 110 Glu Ser Ser Val Leu Leu Ile Met Ser Phe Asp Arg Phe Leu Ala Ile 115 120 125 His Asn Pro Leu Arg Tyr Thr Ser Ile Leu Thr Thr Val Arg Val Ala 130 135 140 Gln Ile Gly Ile Val Phe Ser Phe Lys Ser Met Leu Leu Val Leu Pro 145 150 155 160 Phe Pro Phe Thr Leu Arg Asn Leu Arg Tyr Cys Lys Lys Asn Gln Leu 165 170 175 Ser His Ser Tyr Cys Leu His Gln Asp Val Met Lys Leu Ala Cys Ser 180 185 190 Asp Asn Arg Ile Asp Val Ile Tyr Gly Phe Phe Gly Ala Leu Cys Leu 195 200 205 Met Val Asp Phe Ile Leu Ile Ala Val Ser Tyr Thr Leu Ile Leu Lys 210 215 220 Thr Val Pro Gly Ile Ala Ser Lys Lys Glu Gln Leu Lys Ala Leu Asn 225 230 235 240 Thr Cys Val Ser His Ile Cys Ala Val Ile Ile Phe Tyr Leu Pro Ile 245 250 255 Ile Asn Leu Ala Val Val His Arg Phe Ala Arg His Val Ser Pro Leu 260 265 270 Ile Asn Val Leu Met Ala Asn Val Leu Leu Leu Val Pro Pro Leu Met 275 280 285 Asn Pro Ile Val Tyr Cys Val Lys Thr Lys Gln Ile Arg Val Arg Val 290 295 300 Val Ala Lys Leu Cys Gln Arg Lys Ile 305 310 <210> 141 <211> 945 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(945) <400> 141 atg acc ctg gga tcc ctg gga aac agc agc agc agc gtt tct gct acc 48 Met Thr Leu Gly Ser Leu Gly Asn Ser Ser Ser Ser Val Ser Ala Thr 1 5 10 15 ttc ctg ctg agt ggc atc cct ggg ctg gag cgc atg cac atc tgg atc 96 Phe Leu Leu Ser Gly Ile Pro Gly Leu Glu Arg Met His Ile Trp Ile 20 25 30 tcc atc cca ctg tgc ttc atg tat ctg gtt tcc atc ccg ggc aac tgc 144 Ser Ile Pro Leu Cys Phe Met Tyr Leu Val Ser Ile Pro Gly Asn Cys 35 40 45 aca att ctt ttt atc att aaa aca gag cgc tca ctt cat gaa cct atg 192 Thr Ile Leu Phe Ile Ile Lys Thr Glu Arg Ser Leu His Glu Pro Met 50 55 60 tat ctc ttc ctg tcc atg ctg gct ctg att gac ctg ggt ctc tcc ctt 240 Tyr Leu Phe Leu Ser Met Leu Ala Leu Ile Asp Leu Gly Leu Ser Leu 65 70 75 80 tgc act ctc cct aca gtc ctg ggc atc ttt tgg gtt gga gca cga gaa 288 Cys Thr Leu Pro Thr Val Leu Gly Ile Phe Trp Val Gly Ala Arg Glu 85 90 95 att agc cat gat gcc tgc ttt gct cag ctc ttt ttc att cac tgc ttc 336 Ile Ser His Asp Ala Cys Phe Ala Gln Leu Phe Phe Ile His Cys Phe 100 105 110 tcc ttc ctc gag tcc tct gtg cta ctg tct atg gcc ttt gac cgc ttt 384 Ser Phe Leu Glu Ser Ser Val Leu Leu Ser Met Ala Phe Asp Arg Phe 115 120 125 gtg gct atc tgc cac ccc ttg cac tat gtt tcc att ctc acc aac aca 432 Val Ala Ile Cys His Pro Leu His Tyr Val Ser Ile Leu Thr Asn Thr 130 135 140 gtc att ggc agg att ggc ctg gtc tct ctg ggt cgt agt gta gca ctc 480 Val Ile Gly Arg Ile Gly Leu Val Ser Leu Gly Arg Ser Val Ala Leu 145 150 155 160 att ttt cca tta cct ttt atg ctc aaa aga ttc ccc tat tgt ggc tcc 528 Ile Phe Pro Leu Pro Phe Met Leu Lys Arg Phe Pro Tyr Cys Gly Ser 165 170 175 cca gtt ctc tca cat tct tat tgt ctc cac caa gaa gtg atg aaa ttg 576 Pro Val Leu Ser His Ser Tyr Cys Leu His Gln Glu Val Met Lys Leu 180 185 190 gcc tgt gcc gac atg aag gcc aac agc atc tac ggc atg ttt gtc atc 624 Ala Cys Ala Asp Met Lys Ala Asn Ser Ile Tyr Gly Met Phe Val Ile 195 200 205 gtc tct aca gtg ggt ata gac tca ctg ctc atc ctc ttc tct tat gct 672 Val Ser Thr Val Gly Ile Asp Ser Leu Leu Ile Leu Phe Ser Tyr Ala 210 215 220 ctg atc ctg cgc acc gtg ctg tcc atc gcc tcc agg gct gag aga ttc 720 Leu Ile Leu Arg Thr Val Leu Ser Ile Ala Ser Arg Ala Glu Arg Phe 225 230 235 240 aag gcc ctt aac acc tgt gtt tcc cac atc tgt gct gtg ctg ctc ttc 768 Lys Ala Leu Asn Thr Cys Val Ser His Ile Cys Ala Val Leu Leu Phe 245 250 255 tac act ccc atg att ggc ctc tct gtc atc cat cgc ttt gga aag cag 816 Tyr Thr Pro Met Ile Gly Leu Ser Val Ile His Arg Phe Gly Lys Gln 260 265 270 gca ccc cac ctg gtc cag gtg gtc atg ggt ttc atg tat ctt ctc ttt 864 Ala Pro His Leu Val Gln Val Val Met Gly Phe Met Tyr Leu Leu Phe 275 280 285 cct cct gtg atg aat ccc att gtc tac agt gtg aag acc aaa cag atc 912 Pro Pro Val Met Asn Pro Ile Val Tyr Ser Val Lys Thr Lys Gln Ile 290 295 300 cgg gat cga gtg acg cat gcc ttt tgt tac taa 945 Arg Asp Arg Val Thr His Ala Phe Cys Tyr 305 310 315 <210> 142 <211> 314 <212> PRT <213> Homo sapiens <400> 142 Met Thr Leu Gly Ser Leu Gly Asn Ser Ser Ser Ser Val Ser Ala Thr 1 5 10 15 Phe Leu Leu Ser Gly Ile Pro Gly Leu Glu Arg Met His Ile Trp Ile 20 25 30 Ser Ile Pro Leu Cys Phe Met Tyr Leu Val Ser Ile Pro Gly Asn Cys 35 40 45 Thr Ile Leu Phe Ile Ile Lys Thr Glu Arg Ser Leu His Glu Pro Met 50 55 60 Tyr Leu Phe Leu Ser Met Leu Ala Leu Ile Asp Leu Gly Leu Ser Leu 6 5 70 75 80 Cys Thr Leu Pro Thr Val Leu Gly Ile Phe Trp Val Gly Ala Arg Glu 85 90 95 Ile Ser His Asp Ala Cys Phe Ala Gln Leu Phe Phe Ile His Cys Phe 100 105 110 Ser Phe Leu Glu Ser Ser Val Leu Leu Ser Met Ala Phe Asp Arg Phe 115 120 125 Val Ala Ile Cys His Pro Leu His Tyr Val Ser Ile Leu Thr Asn Thr 130 135 140 Val Ile Gly Arg Ile Gly Leu Val Ser Leu Gly Arg Ser Val Ala Leu 145 150 155 160 Ile Phe Pro Leu Pro Phe Met Leu Lys Arg Phe Pro Tyr Cys Gly Ser 165 170 175 Pro Val Leu Ser His Ser Tyr Cys Leu His Gln Glu Val Met Lys Leu 180 185 190 Ala Cys Ala Asp Met Lys Ala Asn Ser Ile Tyr Gly Met Phe Val Ile 195 200 205 Val Ser Thr Val Gly Ile Asp Ser Leu Leu Ile Leu Phe Ser Tyr Ala 210 215 220 Leu Ile Leu Arg Thr Val Leu Ser Ile Ala Ser Arg Ala Glu Arg Phe 225 230 235 240 Lys Ala Leu Asn Thr Cys Val Ser His Ile Cys Ala Val Leu Leu Phe 245 250 255 Tyr Thr Pro Met Ile Gly Leu Ser Val Ile His Arg Phe Gly Lys Gln 260 265 270 Ala Pro His Leu Val Gln Val Val Met Gly Phe Met Tyr Leu Leu Phe 275 280 285 Pro Pro Val Met Asn Pro Ile Val Tyr Ser Val Lys Thr Lys Gln Ile 290 295 300 Arg Asp Arg Val Thr His Ala Phe Cys Tyr 305 310 < 210> 143 <211> 966 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(966) <400> 143 atg aca att ctt ctt aat agc agc ctc caa aga gcc act ttc ttc ctg 48 Met Thr Ile Leu Leu Asn Ser Ser Leu Gln Arg Ala Thr Phe Phe Leu 1 5 10 15 acg ggc ttc caa ggt cta gaa ggt ctc cat ggc tgg atc tct att ccc 96 Thr Gly Phe Gln Gly Leu Glu Gly Leu His Gly Trp Ile Ser Ile Pro 20 25 30 ttc tgc ttc atc tac ctg aca gtt atc ttg ggg aac ctc acc att ctc 144 Phe Cys Phe Ile Tyr Leu Thr Val Ile Leu Gly Asn Leu Thr Ile Leu 35 40 45 cac gtc att tgt act gat gcc act ctc cat gga ccc atg tac tat ttc 192 His Val Ile Cys Thr Asp Ala Thr Leu His Gly Pro Met Tyr Tyr Phe 50 55 60 ttg ggc atg cta gct gtc aca gac tta ggc ctt tgc ctt tcc aca ctg 240 Leu Gly Met Leu Ala Val Thr Asp Leu Gly Leu Cys Leu Ser Thr Leu 65 70 75 80 ccc act gtg ctg ggc att ttc tgg ttt gat acc aga gag att ggc atc 288 Pro Thr Val Leu Gly Ile Phe Trp Phe Asp Thr Arg Glu Ile Gly Ile 85 90 95 cct gcc tgt ttc act cag ctc ttc ttc atc cac acc ttg tct tca atg 336 Pro Ala Cys Phe Thr Gln Leu Phe Phe Ile His Thr Leu Ser Ser Met 100 105 110 gag tca tca gtt ctg tta tcc atg tcc att gac cgc tcc gtg gcc gtc 384 Glu Ser Ser Val Leu Leu Ser Met Ser Ile Asp Arg Ser Val Ala Val 115 120 125 tgc aac cca ctg cat gac tcc acc gtc ctg aca cct gca tgt att gtc 432 Cys Asn Pro Leu His Asp Ser Thr Val Leu Thr Pro Ala Cys Ile Val 130 135 140 aag atg ggg cta agc tca gtg ctt aga agt gct ctc ctc atc ctc ccc 480 Lys Met Gly Leu Ser Ser Val Leu Arg Ser Ala Leu Leu Ile Leu Pro 145 150 155 160 ttg cca ttc ctc ctg aag cgc ttc caa tac tgc cac tcc cat gtg ctg 528 Leu Pro Phe Leu Leu Lys Arg Phe Gln Tyr Cys His Ser His Val Leu 165 170 175 gct cat gct tat tgt ctt cac ctg gag atc atg aag ctg gcc tgc tct 576 Ala His Ala Tyr Cys Leu His Leu Glu Ile Met Lys Leu Ala Cys Ser 180 185 190 agc atc att gtc aat cac atc tat ggg ctc ttt gtt gtg gcc tgc acc 624 Ser Ile Ile Val Asn His Ile Tyr Gly Leu Phe Val Val Ala Cys Thr 195 200 205 gtg ggt gtg gac tcc ctg ctc atc ttt ctc tca tac gcc ctc atc ctt 672 Val Gly Val Asp Ser Leu Leu Ile Phe Leu Ser Tyr Ala Leu Ile Leu 210 215 220 cgc acc gtg ctc agc att gcc tcc cac cag gag cga ctc cga gcc ctc 720 Arg Thr Val Leu Ser Ile Ala Ser His Gln Glu Arg Leu Arg Ala Leu 225 230 235 240 aac acc tgt gtc tct cat atc tgt gct gta ctg ctc ttc tac atc ccc 768 Asn Thr Cys Val Ser His Ile Cys Ala Val Leu Leu Phe Tyr Ile Pro 245 250 255 at g att ggc ttg tct ctt gtg cat cgc ttt ggt gaa cat ctg ccc cgc 816 Met Ile Gly Leu Ser Leu Val His Arg Phe Gly Glu His Leu Pro Arg 260 265 270 gtt gta cac ctc ttc atg tcc tat gtg tat ctg ctg gta cca ccc ctt 864 Val Val His Leu Phe Met Ser Tyr Val Tyr Leu Leu Val Pro Pro Leu 275 280 285 atg aac ccc atc atc tac agc atc aag acc aag caa att cgc cag cgc 912 Met Asn Pro Ile Ile Tyr Ser Ile Lys Thr Lys Gln Ile Arg Gln Arg 290 295 300 atc att aag aag ttt cag ttt ata aag tca ctt agg tgt ttt tgg aag 960 Ile Ile Lys Lys Phe Gln Phe Ile Lys Ser Leu Arg Cys Phe Trp Lys 305 310 315 320 gat taa 966 Asp <210> 144 <211> 321 <212> PRT <213> Homo sapiens <400> 144 Met Thr Ile Leu Leu Asn Ser Ser Leu Gln Arg Ala Thr Phe Phe Leu 1 5 10 15 Thr Gly Phe Gln Gly Leu Glu Gly Leu His Gly Trp Ile Ser Ile Pro 20 25 30 Phe Cys Phe Ile Tyr Leu Thr Val Ile Leu Gly Asn Leu Thr Ile Leu 35 40 45 His Val Ile Cys Thr Asp Ala Thr Leu His Gly Pro Met Tyr Tyr Phe 50 55 60 Leu Gly Met Leu Ala Val Thr Asp Leu Gly Leu Cys Leu Ser Thr Leu 65 70 75 80 Pro Thr Val Leu Gly Ile Phe Trp Phe Asp Thr Arg Glu Ile Gly Ile 85 90 95 Pro Ala Cys Phe Thr Gln Leu Phe Phe Ile His Thr Leu Ser Ser Met 100 105 110 Glu Ser Ser Val Leu Leu Ser Met Ser Ile Asp Arg Ser Val Ala Val 115 120 125 Cys Asn Pro Leu His Asp Ser Thr Val Leu Thr Pro Ala Cys Ile Val 130 135 140 Lys Met Gly Leu Ser Ser Val Leu Arg Ser Ala Leu Leu Ile Leu Pro 145 150 155 160 Leu Pro Phe Leu Leu Lys Arg Phe Gln Tyr Cys His Ser His Val Leu 165 170 175 Ala His Ala Tyr Cys Leu His Leu Glu Ile Met Lys Leu Ala Cys Ser 180 185 190 Ser Ile Ile Val Asn His Ile Tyr Gly Leu Phe Val Val Ala Cys Thr 195 200 205 Val Gly Val Asp Ser Leu Leu Ile Phe Leu Ser Tyr Ala Leu Ile Leu 210 215 220 Arg Thr Val Leu Ser Ile Ala Ser His Gln Glu Arg Leu Arg Ala Leu 225 230 235 240 Asn Thr Cys Val Ser His Ile Cys Ala Val Leu Leu Phe Tyr Ile Pro 245 250 255 Met Ile Gly Leu Ser Leu Val His Arg Phe Gly Glu His Leu Pro Arg 260 265 270 Val Val His Leu Phe Met Ser Tyr Val Tyr Leu Leu Val Pro Pro Leu 275 280 285 Met Asn Pro Ile Ile Tyr Ser Ile Lys Thr Lys Gln Ile Arg Gln Arg 290 295 300 Ile Ile Lys Lys Phe Gln Phe Ile Lys Ser Leu Arg Cys Phe Trp Lys 305 310 315 320 Asp <210> 145 <211> 765 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(765) <400> 145 atg tac tat ttc ctc tcc atg ctg tcc gcc act gac ctc ggc ctg tcc 48 Met Tyr Tyr Phe Leu Ser Met Leu Ser Ala Thr Asp Leu Gly Leu Ser 1 5 10 15 ata tcc act ctg gtc acc atg ctg agt ata ttc tgg ttc aat gtg agg 96 Ile Ser Thr Leu Val Thr Met Leu Ser Ile Phe Trp Phe Asn Val Arg 20 25 30 gaa atc agc ttt aat gcc tgc ttg tcc cac atg ttc ttt att aaa ttc 144 Glu Ile Ser Phe Asn Ala Cys Leu Ser His Met Phe Phe Ile Lys Phe 35 40 45 ttc act gtc atg gaa tcc tca gtg ctg ttg gcc atg gct ttt gat cgt 192 Phe Thr Val Met Glu Ser Ser Val Leu Leu Ala Met Ala Phe Asp Arg 50 55 60 ttt gtg gcc gtc tct aat ccc ctt agg tat gcc atg att tta act gac 240 Phe Val Ala Val Ser Asn Pro Leu Arg Tyr Ala Met Ile Leu Thr Asp 65 70 75 80 tcc aga ata gct caa att gga gtg gca agt gtc atc agg ggg ctc cta 288 Ser Arg Ile Ala Gln Ile Gly Val Ala Ser Val Ile Arg Gly Leu Leu 85 90 95 atg ctg aca cca atg gta gca ctt ctt ata aga ctt tcc tac tgc cac 336 Met Leu Thr Pro Met Val Ala Leu Leu Ile Arg Leu Ser Tyr Cys His 100 105 110 agc caa gta ctc cac cac tcc tac tgc tac cac cct gat gtg atg aag 384 Ser Gln Val Leu His His Ser Tyr Cys Tyr His Pro Asp Val Met Lys 115 120 125 ctc tca tgc aca gac acc aga atc aac agt gca gtt ggg ctg act gcc 432 Leu Ser Cys Thr Asp Thr Arg Ile Asn Ser Ala Val Gly Leu Thr Ala 130 135 140 atg ttc tct act gtt ggt gta gac tta ctt ctc atc ctc ctt tct tat 480 Met Phe Ser Thr Val Gly Val Asp Leu Leu Leu Ile Leu Leu Ser Tyr 145 150 155 160 gtt ttg atc att agg act gtc ctt agc gtt gct tcc cca gaa gag agg 528 Val Leu Ile Ile Arg Thr Val Leu Ser Val Ala Ser Pro Glu Glu Arg 165 170 175 aag gaa acc ttc agt aca tgt gtc tcc cac att gtg gct ttt gct ata 576 Lys Glu Thr Phe Ser Thr Cys Val Ser His Ile Val Ala Phe Ala Ile 180 185 190 tat tac att cca ttg atc agt ctg tcc att gtt cac aga ttt ggg aaa 624 Tyr Tyr Ile Pro Leu Ile Ser Leu Ser Ile Val His Arg Phe Gly Lys 195 200 205 caa gcc cca gcc tat gta cat act atg att gct aac acc tac ctg ctg 672 Gln Ala Pro Ala Tyr Val His Thr Met Ile Ala Asn Thr Tyr Leu Leu 210 215 220 atc tcc cct ttg atg aac cct gtc atc tac agt gtg aaa acc aaa cag 720 Ile Ser Pro Leu Met Asn Pro Val Ile Tyr Ser Val Lys Thr Lys Gln 225 230 235 240 ata cgt aga gct gtg ata aaa att ctc cat tcc aaa gaa aca taa 765 Ile Arg Arg Ala Val Ile Lys Ile Leu His Ser Lys Glu Thr 245 250 255 <210> 146 <211> 254 <212> PRT <213> Homo sapiens <400> 146 Met Tyr Tyr Phe Leu Ser Met Leu Ser Ala Thr Asp Leu Gly Leu Ser 1 5 10 15 Ile Ser Thr Leu Val Thr Met Leu Ser Ile Phe Trp Phe Asn Val Arg 20 25 30 Glu Ile Ser Phe Asn Ala Cys Leu Ser His Met Phe Phe Ile Lys Phe 35 40 45 Phe Thr Val Met Glu Ser Ser Val Leu Leu Ala Met Ala Phe Asp Arg 50 55 60 Phe Val Ala Val Ser Asn Pro Leu Arg Tyr Ala Met Ile Leu Thr Asp 65 70 75 80 Ser Arg Ile Ala Gln Ile Gly Val Ala Ser Val Ile Arg Gly Leu Leu 85 90 95 Met Leu Thr Pro Met Val Ala Leu Leu Ile Arg Leu Ser Tyr Cys His 100 105 110 Ser Gln Val Leu His His Ser Tyr Cys Tyr His Pro Asp Val Met Lys 115 120 125 Leu Ser Cys Thr Asp Thr Arg Ile Asn Ser Ala Val Gly Leu Thr Ala 130 135 140 Met Phe Ser Thr Val Gly Val Asp Leu Leu Leu Ile Leu Leu Ser Tyr 145 150 155 160 Val Leu Ile Ile Arg Thr Val Leu Ser Val Ala Ser Pro Glu Glu Arg 165 170 175 Lys Glu Thr Phe Ser Thr Cys Val Ser His Ile Val Ala Phe Ala Ile 180 185 190 Tyr Tyr Ile Pro Leu Ile Ser Leu Ser Ile Val His Arg Phe Gly Lys 195 200 205 Gln Ala Pro Ala Tyr Val His Thr Met Ile Ala Asn Thr Tyr Leu Leu 210 215 220 Ile Ser Pro Leu Met Asn Pro Val Ile Tyr Ser Val Lys Thr Lys Gln 225 230 235 240 Ile Arg Arg Ala Val Ile Lys Ile Leu His Ser Lys Glu Thr 245 250 <210> 147 <211> 612 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(612) <400> 147 atg aat gtc ttt cta ctg aca ggc atc ctg gca atg tcc tcc tat cta 48 Met Asn Val Phe Leu Leu Thr Gly Ile Leu Ala Met Ser Ser Tyr Leu 1 5 10 15 ctc aga ttg aag aac tca cat ctc tcc aga gcc ttc ggc tgc ctc cct 96 Leu Arg Leu Lys Asn Ser His Leu Ser Arg Ala Phe Gly Cys Leu Pro 20 25 30 agg atg ctc cct tcc cag acc tat gtc aac atc tcc ttc ttc caa ccg 144 Arg Met Leu Pro Ser Gln Thr Tyr Val Asn Ile Ser Phe Phe Gln Pro 35 40 45 cct gct ctt ctc atg att ggc atc cca ggg ctg gag gcg gtt cat ggc 192 Pro Ala Leu Leu Met Ile Gly Ile Pro Gly Leu Glu Ala Val His Gly 50 55 60 tgg ctc gcc atc ccc ttc tcc tcc atg tac act gtg gcc ctc cct ggg 240 Trp Leu Ala Ile Pro Phe Ser Ser Met Tyr Thr Val Ala Leu Pro Gly 65 70 75 80 aac tgc ctg atc ctc ctg gct gtg aag agg aac ccc agc ctg cac cag 288 Asn Cys Leu Ile Leu Leu Ala Val Lys Arg Asn Pro Ser Leu His Gln 85 90 95 ccc atg tgc tac ttc ctg tcc atg ctg gcg ctc ccc aaa gcg ggc ctc 336 Pro Met Cys Tyr Phe Leu Ser Met Leu Ala Leu Pro Lys Ala Gly Leu 100 105 110 acc ttg tcc aca ctg ccc atc acc ttg gct gtg ctc tgg ttt gac cac 384 T hr Leu Ser Thr Leu Pro Ile Thr Leu Ala Val Leu Trp Phe Asp His 115 120 125 cgg ctc atg ggc ttc aat gcc tgc ctg gtc cag atg ttc ttc ctg cac 432 Arg Leu Met Gly Phe Asn Ala Cys Leu Val Gln Met Phe Phe Leu His 130 135 140 tcc tct gtg gtg gag tcc tca gtg ctc ctg gcc ata tcc ttt gac cac 480 Ser Ser Val Val Glu Ser Ser Val Leu Leu Ala Ile Ser Phe Asp His 145 150 155 160 ttt gtg gcc atc tcc aac ccc ctg cac tat gca gct gtc ctc aca aat 528 Phe Val Ala Ile Ser Asn Pro Leu His Tyr Ala Ala Val Leu Thr Asn 165 170 175 agt gtc atc atc agg att ggg ctg gcc att gtg gct caa gtt acc ttg 576 Ser Val Ile Ile Arg Ile Gly Leu Ala Ile Val Ala Gln Val Thr Leu 180 185 190 tgc ctc ttc ctg tgc cat ttc cgg tta aga gtc taa 612 Cys Leu Phe Leu Cys His Phe Arg Leu Arg Val 195 200 <210> 148 <211> 203 <212> PRT <213> Homo sapiens <400> 148 Met Asn Val Phe Leu Leu Thr Gly Ile Leu Ala Met Ser Ser Tyr Leu 1 5 10 15 Leu Arg Leu Lys Asn Ser His Leu Ser Arg Ala Phe Gly Cys Leu Pro 20 25 30 Arg Met Leu Pro Ser Gln Thr Tyr Val Asn Ile Ser Phe Phe Gln Pro 35 40 45 Pro Ala Leu Leu Met Ile Gly Ile Pro Gly Leu Glu Ala Val His Gly 50 55 60 Trp Leu Ala Ile Pro Phe Ser Ser Met Tyr Thr Val Ala Leu Pro Gly 65 70 75 80 Asn Cys Leu Ile Leu Leu Ala Val Lys Arg Asn Pro Ser Leu His Gln 85 90 95 Pro Met Cys Tyr Phe Leu Ser Met Leu Ala Leu Pro Lys Ala Gly Leu 100 105 110 Thr Leu Ser Thr Leu Pro Ile Thr Leu Ala Val Leu Trp Phe Asp His 115 120 125 Arg Leu Met Gly Phe Asn Ala Cys Leu Val Gln Met Phe Phe Leu His 130 135 140 Ser Ser Val Val Glu Ser Ser Val Leu Leu Ala Ile Ser Phe Asp His 145 150 155 160 Phe Val Ala Ile Ser Asn Pro Leu His Tyr Ala Ala Val Leu Thr Asn 165 170 175 Ser Val Ile Ile Arg Ile Gly Leu Ala Ile Val Ala Gln Val Thr Leu 180 185 190 Cys Leu Phe Leu Cys His Phe Arg Leu Arg Val 195 200 <210> 149 <211> 975 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(975) <400> 149 atg ctg ggt cca gct tac aac cac aca atg gaa acc cct gcc tcc ttc 48 Met Leu Gly Pro Ala Tyr Asn His Thr Met Glu Thr Pro Ala Ser Phe 1 5 10 15 ctc ctt gtg ggt atc cca gga ctg caa tct tca cat ctt tgg ctg gct 96 Leu Leu Val Gly Ile Pro Gly Leu Gln Ser Ser His Leu Trp Leu Ala 20 25 30 atc tca ctg agt gcc atg tac atc aca gcc ctg tta gga aac acc ctc 144 Ile Ser Leu Ser Ala Met Tyr Ile Thr Ala Leu Leu Gly Asn Thr Leu 35 40 45 atc gtg act gca atc tgg atg gat tcc act cgg cat gag ccc atg tat 192 Ile Val Thr Ala Ile Trp Met Asp Ser Thr Arg His Glu Pro Met Tyr 50 55 60 tgc ttt ctg tgt gtt ctg gct gct gtg gac att gtt atg gcc tcc tcc 240 Cys Phe Leu Cys Val Leu Ala Ala Val Asp Ile Val Met Ala Ser Ser 65 70 75 80 gtg gta ccc aag atg gtg agc atc ttc tgc tcg gga gac agc tcc atc 288 Val Val Pro Lys Met Val Ser Ile Phe Cys Ser Gly Asp Ser Ser Ile 85 90 95 agc ttt agt gct tgt ttc act cag atg ttt ttt gtc cac tta gcc aca 336 Ser Phe Ser Ala Cys Phe Thr Gln Met Phe Phe Val His Leu Ala Thr 100 105 110 gct gtg gag acg ggg ctg ctg ctg acc atg gct ttt gac cgc tat gta 384 Ala Val Glu Thr Gly Leu Leu Leu Thr Met Ala Phe Asp Arg Tyr Val 115 120 125 gcc atc tgc aag cct cta cac tac aag aga att ctc acg cct caa gtg 432 Ala Ile Cys Lys Pro Leu His Tyr Lys Arg Ile Leu Thr Pro Gln Val 130 135 140 atg ctg gga atg agt atg gcc gtc acc atc aga gct gtc aca ttc atg 480 Met Leu Gly Met Ser Met Ala Val Thr Ile Arg Ala Val Thr Phe Met 145 150 155 160 act cca ctg agt tgg atg atg aat cat cta cct ttc tgt ggc tcc aat 528 Thr Pro Leu Ser Trp Met Met Asn His Leu Pro Phe Cys Gly Ser Asn 165 170 175 gtg gtt gtc cac tcc tac tgt aag cac ata gct ttg gcc agg tta gca 576 Val Val Val His Ser Tyr Cys Lys His Ile Ala Leu Ala Arg Leu Ala 180 185 190 tgt gct gac ccc gtg ccc agc agt ctc tac agt ctg att ggt tcc tct 624 Cys Ala Asp Pro Val Pro Ser Ser Leu Tyr Ser Leu Ile Gly Ser Ser 195 200 205 ctt atg gtg ggc tct gat gtg gcc ttc att gct gcc tcc tat atc tta 672 Leu Met Val Gly Ser Asp Val Ala Phe Ile Ala Ala Ser Tyr Ile Leu 210 215 220 att ctc agg gca gta ttt gat ctc tcc tca aag act gct cag ttg aaa 720 Ile Leu Arg Ala Val Phe Asp Leu Ser Ser Lys Thr Ala Gln Leu Lys 225 230 235 240 gca tta agc aca tgt ggc tcc cat gtg ggg gtt atg gct ttg tac tat 768 Ala Leu Ser Thr Cys Gly Ser His Val Gly Val Met Ala Leu Tyr Tyr 245 250 255 cta cct ggg atg gca tcc atc tat gcg gcc tgg ttg ggg cag gat ata 816 Leu Pro Gly Met Ala Ser Ile Tyr Ala Ala Trp Leu Gly Gln Asp Ile 260 265 270 gtg ccc ttg cac acc caa gtg ctg cta gct gac ctg tac gtg atc atc 864 Val Pro Leu His Thr Gln Val Leu Leu Ala Asp Leu Tyr Val Ile Ile 275 280 285 cca gcc act tta aat ccc atc atc tat ggc atg agg acc aaa caa ttg 912 Pro Ala Thr Leu Asn Pro Ile Ile Tyr Gly Met Arg Thr Lys Gln Leu 290 295 300 ctg gag gga ata tgg agt tat ctg atg cac ttc ctc ttt gac cac tcc 960 Leu Glu Gly Ile Trp Ser Tyr Leu Met His Phe Leu Phe Asp His Ser 305 310 315 320 aac ctg ggt tca tga 975 Asn Leu Gly Ser 325 <210> 150 <211> 324 <212> PRT <213> Homo sapiens <400> 150 Met Leu Gly Pro Ala Tyr Asn His Thr Met Glu Thr Pro Ala Ser Phe 1 5 10 15 Leu Leu Val Gly Ile Pro Gly Leu Gln Ser Ser His Leu Trp Leu Ala 20 25 30 Ile Ser Leu Ser Ala Met Tyr Ile Thr Ala Leu Leu Gly Asn Thr Leu 35 40 45 Ile Val Thr Ala Ile Trp Met Asp Ser Thr Arg His Glu Pro Met Tyr 50 55 60 Cys Phe Leu Cys Val Leu Ala Ala Val Asp Ile Val Met Ala Ser Ser 65 70 75 80 Val Val Pro Lys Met Val Ser Ile Phe Cys Ser Gly Asp Ser Ser Ile 85 90 95 Ser Phe Ser Ala Cys Phe Thr Gln Met Phe Phe Val His Leu Ala Thr 100 105 110 Ala Val Glu Thr Gly Leu Leu Leu Thr Met Ala Phe Asp Arg Tyr Val 115 120 125 Ala Ile Cys Lys Pro Leu His Tyr Lys Arg Ile Leu Thr Pro Gln Val 130 135 140 Met Leu Gly Met Ser Met Ala Val Thr Ile Arg Ala Val Thr Phe Met 145 150 155 160 Thr Pro Leu Ser Trp Met Met Asn His Leu Pro Phe Cys Gly Ser Asn 165 170 175 Val Val Val His Ser Tyr Cys Lys His Ile Ala Leu Ala Arg Leu Ala 180 185 190 Cys Ala Asp Pro Val Pro Ser Ser Leu Tyr Ser Leu Ile Gly Ser Ser 195 200 205 Leu Met Val Gly Ser Asp Val Ala Phe Ile Ala Ala Ser Tyr Ile Leu 210 215 220 Ile Leu Arg Ala Val Phe Asp Leu Ser Ser Lys Thr Ala Gln Leu Lys 225 230 235 240 Ala Leu Ser Thr Cys Gly Ser His Val Gly Val Met Ala Leu Tyr Tyr 245 250 255 Leu Pro Gly Met Ala Ser Ile Tyr Ala Ala Trp Leu Gly Gln Asp Ile 260 265 270 Val Pro Leu His Thr Gln Val Leu Leu Ala Asp Leu Tyr Val Ile Ile 275 280 285 Pro Ala Thr Leu Asn Pro Ile Ile Tyr Gly Met Arg Thr Lys Gln Leu 290 295 300 Leu Glu Gly Ile Trp Ser Tyr Leu Met His Phe Leu Phe Asp His Ser 305 310 315 320 Asn Leu Gly Ser <210> 151 <211> 963 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(963) <400> 151 atg agt tcc tgc aac ttc aca cat gcc acc ttt gtg ctt att ggt atc 48 Met Ser Ser Cys Asn Phe Thr His Ala Thr Phe Val Leu Ile Gly Ile 1 5 10 15 cca gga tta gag aaa gcc cat ttc tgg gtt ggc ttc ccc ctc ctt tcc 96 Pro Gly Leu Glu Lys Ala His Phe Trp Val Gly Phe Pro Leu Leu Ser 20 25 30 atg tat gta gtg gca atg ttt gga aac tgc atc gtg gtc ttc atc gta 144 Met Tyr Val Val Ala Met Phe Gly Asn Cys Ile Val Val Phe Ile Val 35 40 45 agg acg gaa cgc agc ctg cac gct ccg atg tac ctc ttt ctc tgc atg 192 Arg Thr Glu Arg Ser Leu His Ala Pro Met Tyr Leu Phe Leu Cys Met 50 55 60 ctt gca gcc att gac ctg gcc tta tcc aca tcc acc atg cct aag atc 240 Leu Ala Ala Ile Asp Leu Ala Leu Ser Thr Ser Thr Met Pro Lys Ile 65 70 75 80 ctt gcc ctt ttc tgg ttt gat tcc cga gag att agc ttt gag gcc tgt 288 Leu Ala Leu Phe Trp Phe Asp Ser Arg Glu Ile Ser Phe Glu Ala Cys 85 90 95 ctt acc cag atg ttc ttt att cat gcc ctc tca gcc att gaa tcc acc 336 Leu Thr Gln Met Phe Phe Ile His Ala Leu Ser Ala Ile Glu Ser Thr 100 105 110 atc ctg ctg gcc atg gcc ttt gac cgt tat gtg gcc atc tgc cac cca 384 Ile Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys His Pro 115 120 125 ctg cgc cat gct gca gtg ctc aac aat aca gta aca gcc cag att ggc 432 Leu Arg His Ala Ala Val Leu Asn Asn Thr Val Thr Ala Gln Ile Gly 130 135 140 atc gtg gct gtg gtc cgc gga tcc ctc ttt ttt ttc cca ctg cct ctg 480 Ile Val Ala Val Val Arg Gly Ser Leu Phe Phe Phe Pro Leu Pro Leu 145 150 155 160 ctg atc aag cgg ctg gcc ttc tgc cac tcc aat gtc ctc tcg cac tcc 528 Leu Ile Lys Arg Leu Ala Phe Cys His Ser Asn Val Leu Ser His Ser 165 170 175 tat tgt gtc cac cag gat gta atg aag ttg gcc tat gca gac act ttg 576 Tyr Cys Val His Gln Asp Val Met Lys Leu Ala Tyr Ala Asp Thr Leu 180 185 190 ccc aat gtg gta tat ggt ctt act gcc att ctg ctg gtc atg ggc gtg 624 Pro Asn Val Val Tyr Gly Leu Thr Ala Ile Leu Leu Val Met Gly Val 195 200 205 gac gta atg ttc atc tcc ttg tcc tat ttt ctg ata ata cga acg gtt 672 Asp Val Met Phe Ile Ser Leu Ser Tyr Phe Leu Ile Ile Arg Thr Val 210 215 220 ctg caa ctg cct tcc aag tca gag cgg gcc aag gcc ttt gga acc tgt 720 Leu Gln Leu Pro Ser Lys Ser Glu Arg Ala Lys Ala Phe Gly Thr Cys 225 230 235 240 gtg tca cac att ggt gtg gta ctc gcc ttc tat gtg cca ctt att ggc 768 Val Ser His Ile Gly Val Val Leu Ala Phe Tyr Val Pro Leu Ile Gly 245 250 255 ctc tca gtg gta cac cgc ttt gga aac agc ctt cat ccc att gtg cgt 816 Leu Ser Val Val His Arg Phe Gly Asn Ser Leu His Pro Ile Val Arg 260 265 270 gtt gtc atg ggt gac atc tac ctg ctg ctg cct cct gtc atc aat ccc 864 Val Val Met Gly Asp Ile Tyr Leu Leu Leu Pro Pro Val Ile Asn Pro 275 280 285 atc atc tat ggt gcc aaa acc aaa cag atc aga aca cgg gtg ctg gct 912 Ile Ile Tyr Gly Ala Lys Thr Lys Gln Ile Arg Thr Arg Val Leu Ala 290 295 300 atg ttc aag atc agc tgt gac aag gac ttg cag gct gtg gga ggc aag 960 Met Phe Lys Ile Ser Cys Asp Lys Asp Leu Gln Ala Val Gly Gly Lys 305 310 315 320 tga 963 <210> 152 <211> 320 <212> PRT <213> Homo sapiens <400> 152 Met Ser Ser Cys Asn Phe Thr His Ala Thr Phe Val Leu Ile Gly Ile 1 5 10 15 P ro Gly Leu Glu Lys Ala His Phe Trp Val Gly Phe Pro Leu Leu Ser 20 25 30 Met Tyr Val Val Ala Met Phe Gly Asn Cys Ile Val Val Phe Ile Val 35 40 45 Arg Thr Glu Arg Ser Leu His Ala Pro Met Tyr Leu Phe Leu Cys Met 50 55 60 Leu Ala Ala Ile Asp Leu Ala Leu Ser Thr Ser Thr Met Pro Lys Ile 65 70 75 80 Leu Ala Leu Phe Trp Phe Asp Ser Arg Glu Ile Ser Phe Glu Ala Cys 85 90 95 Leu Thr Gln Met Phe Phe Ile His Ala Leu Ser Ala Ile Glu Ser Thr 100 105 110 Ile Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys His Pro 115 120 125 Leu Arg His Ala Ala Val Leu Asn Asn Thr Val Thr Ala Gln Ile Gly 130 135 140 Ile Val Ala Val Val Arg Gly Ser Leu Phe Phe Phe Pro Leu Pro Leu 145 150 155 160 Leu Ile Lys Arg Leu Ala Phe Cys His Ser Asn Val Leu Ser His Ser 165 170 175 Tyr Cys Val His Gln Asp Val Met Lys Leu Ala Tyr Ala Asp Thr Leu 180 185 190 Pro Asn Val Val Tyr Gly Leu Thr Ala Ile Leu Leu Val Met Gly Val 195 200 205 Asp Val Met Phe Ile Ser Leu Ser Tyr Phe Leu Ile Ile Arg Thr Val 210 215 220 Leu Gln Leu Pro Ser Lys Ser Glu Arg Ala Lys Ala Phe Gly Thr Cys 225 230 235 240 Val Ser His Ile Gly Val Val Leu Ala Phe Tyr Val Pro Leu Ile Gly 245 250 255 Leu Ser Val Val His Arg Phe Gly Asn Ser Leu His Pro Ile Val Arg 260 265 270 Val Val Met Gly Asp Ile Tyr Leu Leu Leu Pro Pro Val Ile Asn Pro 275 280 285 Ile Ile Tyr Gly Ala Lys Thr Lys Gln Ile Arg Thr Arg Val Leu Ala 290 295 300 Met Phe Lys Ile Ser Cys Asp Lys Asp Leu Gln Ala Val Gly Gly Lys 305 310 315 320 <210> 153 <211> 954 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(954) <400> 153 atg ctc act ttt cat aat gtc tgc tca gta ccc agc tcc ttc tgg ctc 48 Met Leu Thr Phe His Asn Val Cys Ser Val Pro Ser Ser Phe Trp Leu 1 5 10 15 act ggc atc cca ggg ctg gag tcc cta cac gtc tgg ctc tcc atc ccc 96 Thr Gly Ile Pro Gly Leu Glu Ser Leu His Val Trp Leu Ser Ile Pro 20 25 30 ttt ggc tcc atg tac ctg gtg gct gtg gtg ggg aat gtg acc atc ctg 144 Phe Gly Ser Met Tyr Leu Val Ala Val Val Gly Asn Val Thr Ile Leu 35 40 45 gct gtg gta aag ata gaa cgc agc ctg cac cag ccc atg tac ttt ttc 192 Ala Val Val Lys Ile Glu Arg Ser Leu His Gln Pro Met Tyr Phe Phe 50 55 60 ttg tgc atg ttg gct gcc att gac ctg gtt ctg tct act tcc act ata 240 Leu Cys Met Leu Ala Ala Ile Asp Leu Val Leu Ser Thr Ser Thr Ile 65 70 75 80 ccc aaa ctt ctg gga atc ttc tgg ttc ggt gct tgt gac att ggc ctg 288 Pro Lys Leu Leu Gly Ile Phe Trp Phe Gly Ala Cys Asp Ile Gly Leu 85 90 95 gac gcc tgc ttg ggc caa atg ttc ctt atc cac tgc ttt gcc act gtt 336 Asp Ala Cys Leu Gly Gln Met Phe Leu Ile His Cys Phe Ala Thr Val 100 105 110 gag tca ggc atc ttc ctt gcc atg gct ttt gat cgc tac gtg gcc atc 384 Glu Ser Gly Ile Phe Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile 115 120 125 tgc aac cca cta cgt cat agc atg gtg ctc act tat aca gtg gtg ggt 432 Cys Asn Pro Leu Arg His Ser Met Val Leu Thr Tyr Thr Val Val Gly 130 135 140 cgt ttg ggg ctt gtt tct ctc ctc cgg ggt gtt ctc tac att gga cct 480 Arg Leu Gly Leu Val Ser Leu Leu Arg Gly Val Leu Tyr Ile Gly Pro 145 150 155 160 ctg cct ctg atg atc cgc ctg cgg ctg ccc ctt tat aaa acc cat gtt 528 Leu Pro Leu Met Ile Arg Leu Arg Leu Pro Leu Tyr Lys Thr His Val 165 170 175 atc tcc cac tcc tac tgt gag cac atg gct gta gtt gcc ttg aca tgt 576 Ile Ser His Ser Tyr Cys Glu His Met Ala Val Val Ala Leu Thr Cys 180 185 190 ggc gac agc agg gtc aat aat gtc tat ggg ctg agc atc ggc ttt ctg 624 Gly Asp Ser Arg Val Asn Asn Val Tyr Gly Leu Ser Ile Gly Phe Leu 195 200 205 gtg ttg atc ctg gac tca gtg gct att gct gca tcc tat gtg atg att 672 Val Leu Ile Leu Asp Ser Val Ala Ile Ala Ala Ser Tyr Val Met Ile 210 215 220 ttc agg gcc gtg atg ggg tta gcc act cct gag gct agg ctt aaa acc 720 Phe Arg Ala Val Met Gly Leu Ala Thr Pro Glu Ala Arg Leu Lys Thr 225 230 235 240 ctg ggg aca tgc gct tct cac ctc tgt gcc atc ctg atc ttt tat gtt 768 Leu Gly Thr Cys Ala Ser His Leu Cys Ala Ile Leu Ile Phe Tyr Val 245 250 255 ccc att gct gtt tct tcc ctg att cac cga ttt ggt cag tgt gtg cct 816 Pro Ile Ala Val Ser Ser Leu Ile His Arg Phe Gly Gln Cys Val Pro 260 265 270 cct cca gtc cac act ctg ctg gcc aac ttc tat ctc ctc att cct cca 864 Pro Pro Val His Thr Leu Leu Ala Asn Phe Tyr Leu Leu Ile Pro Pro 275 280 285 atc ctc aat ccc att gtc tat gct gtt cgc acc aag cag atc cga gag 912 Ile Leu Asn Pro Ile Val Tyr Ala Val Arg Thr Lys Gln Ile Arg Glu 290 295 300 agc ctt ctc caa ata cca agg ata gaa atg aag att aga tga 954 Ser Leu Leu Gln Ile Pro Arg Ile Glu Met Lys Ile Arg 305 310 315 <210> 154 <211> 317 <212> PRT <213> Homo sapiens <400> 154 Met Leu Thr Phe His Asn Val Cys Ser Val Pro Ser Ser Phe Trp Leu 1 5 10 15 Thr Gly Ile Pro Gly Leu Glu Ser Leu His Val Trp Leu Ser Ile Pro 20 25 30 Phe Gly Ser Met Tyr Leu Val Ala Val Val Gly Asn Val Thr Ile Leu 35 40 45 Ala Val Val Lys Ile Glu Arg Ser Leu His Gln Pro Met Tyr Phe Phe 50 55 60 Leu Cys Met Leu Ala Ala Ile Asp Leu Val Leu Ser Thr Ser Thr Ile 65 70 75 80 Pro Lys Leu Leu Gly Ile Phe Trp Phe Gly Ala Cys Asp Ile Gly Leu 85 90 95 Asp Ala Cys Leu Gly Gln Met Phe Leu Ile His Cys Phe Ala Thr Val 100 105 110 Glu Ser Gly Ile Phe Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile 115 120 125 Cys Asn Pro Leu Arg His Ser Met Val Leu Thr Tyr Thr Val Val Gly 130 135 140 Arg Leu Gly Leu Val Ser Leu Leu Arg Gly Val Leu Tyr Ile Gly Pro 145 150 155 160 Leu Pro Leu Met Ile Arg Leu Arg Leu Pro Leu Tyr Lys Thr His Val 165 170 175 Ile Ser His Ser Tyr Cys Glu His Met Ala Val Val Ala Leu Thr Cys 180 185 190 Gly Asp Ser Arg Val Asn Asn Val Tyr Gly Leu Ser Ile Gly Phe Leu 195 200 205 Val Leu Ile Leu Asp Ser Val Ala Ile Ala Ala Ser Tyr Val Met Ile 210 215 220 Phe Arg Ala Val Met Gly Leu Ala Thr Pro Glu Ala Arg Leu Lys Thr 225 230 235 240 Leu Gly Thr Cys Ala Ser His Leu Cys Ala Ile Leu Ile Phe Tyr Val 245 250 255 Pro Ile Ala Val Ser Ser Leu Ile His Arg Phe Gly Gln Cys Val Pro 260 265 270 Pro Pro Val His Thr Leu Leu Ala Asn Phe Tyr Leu Leu Ile Pro Pro 275 280 285 Ile Leu Asn Pro Ile Val Tyr Ala Val Arg Thr Lys Gln Ile Arg Glu 290 295 300 Ser Leu Leu Gln Ile Pro Arg Ile Glu Met Lys Ile Arg 305 310 315 <210> 155 <211> 975 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(975) <400> 155 atg cag aag ccc cag ctc ttg gtc cct atc ata gcc act tca aat gga 48 Met Gln Lys Pro Gln Leu Leu Val Pro Ile Ile Ala Thr Ser Asn Gly 1 5 10 15 aat ctg gtc cac gca gca tac ttc ctt ttg gtg ggt atc cct ggc ctg 96 Asn Leu Val His Ala Ala Tyr Phe Leu Leu Val Gly Ile Pro Gly Leu 20 25 30 ggg cct acc ata cac ttt tgg ctg gct ttc cca ctg tgt ttt atg tat 144 Gly Pro Thr Ile His Phe Trp Leu Ala Phe Pro Leu Cys Phe Met Tyr 35 40 45 gcc ttg gcc acc ctg ggt aac ctg acc att gtc ctc atc att cgt gtg 192 Ala Leu Ala Thr Leu Gly Asn Leu Thr Ile Val Leu Ile Ile Arg Val 50 55 60 gag agg cga ctg cat gag ccc atg tac ctc ttc ctg gcc atg ctt tcc 240 Glu Arg Arg Leu His Glu Pro Met Tyr Leu Phe Leu Ala Met Leu Ser 65 70 75 80 act att gac cta gtc ctc tcc tct atc acc atg ccc aag atg gcc agt 288 Thr Ile Asp Leu Val Leu Ser Ser Ile Thr Met Pro Lys Met Ala Ser 85 90 95 ctt ttc ctg atg ggc atc cag gag atc gag ttc aac att tgc ctg gcc 336 Leu Phe Leu Met Gly Ile Gln Glu Ile Glu Phe Asn Ile Cys Leu Ala 100 105 110 cag atg ttc ctt atc cat gct ctg tca gcc gtg gag tca gct gtc ctg 384 Gln Met Phe Leu Ile His Ala Leu Ser Ala Val Glu Ser Ala Val Leu 115 120 125 ctg gcc atg gct ttt gac cgc ttt gtg gcc att tgc cac cca ttg cgc 432 Leu Ala Met Ala Phe Asp Arg Phe Val Ala Ile Cys His Pro Leu Arg 130 135 140 cat gct tct gtg ctg aca ggg tgt act gtg gcc aag att gga cta tct 480 His Ala Ser Val Leu Thr Gly Cys Thr Val Ala Lys Ile Gly Leu Ser 145 150 155 160 gcc ctg acc agg ggg ttt gta ttc ttc ttc cca ctg ccc ttc atc ctc 528 Ala Leu Thr Arg Gly Phe Val Phe Phe Phe Pro Leu Pro Phe Ile Leu 165 170 175 aag tgg ttg tcc tac tgc caa aca cat act gtc aca cac tcc ttc tgt 576 Lys Trp Leu Ser Tyr Cys Gln Thr His Thr Val Thr His Ser Phe Cys 180 185 190 ctg cac caa gat att atg aag ctg tcc tgt act gac acc agg gtc aat 624 Leu His Gln Asp Ile Met Lys Leu Ser Cys Thr Asp Thr Arg Val Asn 195 200 205 gtg gtt tat gga ctc ttc atc atc ctc tca gtc atg ggt gtg gac tct 672 Val Val Tyr Gly Leu Phe Ile Ile Leu Ser Val Met Gly Val Asp Ser 210 215 220 ctc ttc att ggc ttc tca tat atc ctc atc ctg tgg gct gtt ttg gag 720 Leu Phe Ile Gly Phe Ser Tyr Ile Leu Ile Leu Trp Ala Val Leu Glu 225 230 235 240 ctg tcc tct cgg agg gca gca ctc aag gct ttc aac acc tgc atc tcc 768 Leu Ser Ser Arg Arg Ala Ala Leu Lys Ala Phe Asn Thr Cys Ile Ser 245 250 255 cac ctc tgt gct gtt ctg gtc ttc tat gta ccc ctc att ggg ctc tcg 816 His Leu Cys Ala Val Leu Val Phe Tyr Val Pro Leu Ile Gly Leu Ser 260 265 270 gtg gtg cat agg ctg ggt ggt ccc acc tcc ctc ctc cat gtg gtt atg 864 Val Val His Arg Leu Gly Gly Pro Thr Ser Leu Leu His Val Val Met 275 280 285 gct aat acc tac ttg ctg cta cca cct gta gtc aac ccc ctt gtc tat 912 Ala Asn Thr Tyr Leu Leu Leu Pro Pro Val Val Asn Pro Leu Val Tyr 290 295 300 gga gcc aag acc aaa gag atc tgt tca agg gtc ctc tgt atg ttc tca 960 Gly Ala Lys Thr Lys Glu Ile Cys Ser Arg Val Leu Cys Met Phe Ser 305 310 315 320 caa ggt ggc aag tga 975 Gln Gly Gly Lys 325 <210> 156 <211> 324 <212> PRT <213> Homo sapiens <400> 156 Met Gln Lys Pro Gln Leu Leu Val Pro Ile Ile Ala Thr Ser Asn Gly 1 5 10 15 Asn Leu Val His Ala Ala Tyr Phe Leu Leu Val Gly Ile Pro Gly Leu 20 25 30 Gly Pro Thr Ile His Phe Trp Leu Ala Phe Pro Leu Cys Phe Met Tyr 35 40 45 Ala Leu Ala Thr Leu Gly Asn Leu Thr Ile Val Leu Ile Ile Arg Val 50 55 60 Glu Arg Arg Leu His Glu Pro Met Tyr Leu Phe Leu Ala Met Leu Ser 65 70 75 80 Thr Ile Asp Leu Val Leu Ser Ser Ile Thr Met Pro Lys Met Ala Ser 85 90 95 Leu Phe Leu Met Gly Ile Gln Glu Ile Glu Phe Asn Ile Cys Leu Ala 100 105 110 Gln Met Phe Leu Ile His Ala Leu Ser Ala Val Glu Ser Ala Val Leu 115 120 125 Leu Ala Met Ala Phe Asp Arg Phe Val Ala Ile Cys His Pro Leu Arg 130 135 140 H is Ala Ser Val Leu Thr Gly Cys Thr Val Ala Lys Ile Gly Leu Ser 145 150 155 160 Ala Leu Thr Arg Gly Phe Val Phe Phe Phe Pro Leu Pro Phe Ile Leu 165 170 175 Lys Trp Leu Ser Tyr Cys Gln Thr His Thr Val Thr His Ser Phe Cys 180 185 190 Leu His Gln Asp Ile Met Lys Leu Ser Cys Thr Asp Thr Arg Val Asn 195 200 205 Val Val Tyr Gly Leu Phe Ile Ile Leu Ser Val Met Gly Val Asp Ser 210 215 220 Leu Phe Ile Gly Phe Ser Tyr Ile Leu Ile Leu Trp Ala Val Leu Glu 225 230 235 240 Leu Ser Ser Arg Arg Ala Ala Leu Lys Ala Phe Asn Thr Cys Ile Ser 245 250 255 His Leu Cys Ala Val Leu Val Phe Tyr Val Pro Leu Ile Gly Leu Ser 260 265 270 Val Val His Arg Leu Gly Gly Pro Thr Ser Leu Leu His Val Val Met 275 280 285 Ala Asn Thr Tyr Leu Leu Leu Pro Pro Val Val Asn Pro Leu Val Tyr 290 295 300 Gly Ala Lys Thr Lys Glu Ile Cys Ser Arg Val Leu Cys Met Phe Ser 305 310 315 320 Gln Gly Gly Lys <210> 157 <211> 957 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(957) <400> 157 atg atg gtg gat ccc aat ggc aat gaa tcc agt gct aca tac ttc atc 48 Met Met Val Asp Pro Asn Gly Asn Glu Ser Ser Ala Thr Tyr Phe Ile 1 5 10 15 cta ata ggc ctc cct ggt tta gaa gag gct cag ttc tgg ttg gcc ttc 96 Leu Ile Gly Leu Pro Gly Leu Glu Glu Ala Gln Phe Trp Leu Ala Phe 20 25 30 cca ttg tgc tcc ctc tac ctt att gct gtg cta ggt aac ttg aca atc 144 Pro Leu Cys Ser Leu Tyr Leu Ile Ala Val Leu Gly Asn Leu Thr Ile 35 40 45 atc tac att gtg cgg act gag cac agc ctg cat gag ccc atg tat ata 192 Ile Tyr Ile Val Arg Thr Glu His Ser Leu His Glu Pro Met Tyr Ile 50 55 60 ttt ctt tgc atg ctt tca ggc att gac atc ctc atc tcc acc tca tcc 240 Phe Leu Cys Met Leu Ser Gly Ile Asp Ile Leu Ile Ser Thr Ser Ser 65 70 75 80 atg ccc aaa atg ctg gcc atc ttc tgg ttc aat tcc act acc atc cag 288 Met Pro Lys Met Leu Ala Ile Phe Trp Phe Asn Ser Thr Thr Ile Gln 85 90 95 ttt gat gct tgt ctg cta cag atg ttt gcc atc cac tcc tta tct ggc 336 Phe Asp Ala Cys Leu Leu Gln Met Phe Ala Ile His Ser Leu Ser Gly 100 105 110 atg gaa tcc aca gtg ctg ctg gcc atg gct ttt gac cgc tat gtg gcc 384 Met Glu Ser Thr Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala 115 120 125 atc tgt cac cca ctg cgc cat gcc aca gta ctt acg ttg cct cgt gtc 432 Ile Cys His Pro Leu Arg His Ala Thr Val Leu Thr Leu Pro Arg Val 130 135 140 acc aaa att ggt gtg gct gct gtg gtg cgg ggg gct gca ctg atg gca 480 Thr Lys Ile Gly Val Ala Ala Val Val Arg Gly Ala Ala Leu Met Ala 145 150 155 160 ccc ctt cct gtc ttc atc aag cag ctg ccc ttc tgc cgc tcc aat atc 528 Pro Leu Pro Val Phe Ile Lys Gln Leu Pro Phe Cys Arg Ser Asn Ile 165 170 175 ctt tcc cat tcc tac tgc cta cac caa gat gtc atg aag ctg gcc tgt 576 Leu Ser His Ser Tyr Cys Leu His Gln Asp Val Met Lys Leu Ala Cys 180 185 190 gat gat atc cgg gtc aat gtc gtc tat ggc ctt atc gtc atc atc tcc 624 Asp Asp Ile Arg Val Asn Val Val Tyr Gly Leu Ile Val Ile Ile Ser 195 200 205 gcc att ggc ctg gac tca ctt ctc atc tcc ttc tca tat ctg ctt att 672 Ala Ile Gly Leu Asp Ser Leu Leu Ile Ser Phe Ser Tyr Leu Leu Ile 210 215 220 ctt aag act gtg ttg ggc ttg aca cgt gaa gcc cag gcc aag gca ttt 720 Leu Lys Thr Val Leu Gly Leu Thr Arg Glu Ala Gln Ala Lys Ala Phe 225 230 235 240 ggc act tgc gtc tct cat gtg tgt gct gtg ttc ata ttc tat gta cct 768 Gly Thr Cys Val Ser His Val Cys Ala Val Phe Ile Phe Tyr Val Pro 245 250 255 ttc att gga ttg tcc atg gtg cat cgc ttt agc aag cgg cgt gac tct 816 Phe Ile Gly Leu Ser Met Val His Arg Phe Ser Lys Arg Arg Asp Ser 260 265 270 ccg ctg ccc gtc atc ttg gcc aat atc tat ctg ctg gtt cct cct gtg 864 Pro Leu Pro Val Ile Leu Ala Asn Ile Tyr Leu Leu Val Pro Pro Val 275 280 285 ctc aac cca att gtc tat gga gtg aag aca aag gag att cga cag cgc 912 Leu Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Glu Ile Arg Gln Arg 290 295 300 atc ctt cga ctt ttc cat gtg gcc aca cac gct tca gag ccc tag 957 Ile Leu Arg Leu Phe His Val Ala Thr His Ala Ser Glu Pro 305 310 315 <210> 158 <211> 318 <212> PRT <213> Homo sapiens <400> 158 Met Met Val Asp Pro Asn Gly Asn Glu Ser Ser Ala Thr Tyr Phe Ile 1 5 10 15 Leu Ile Gly Leu Pro Gly Leu Glu Glu Ala Gln Phe Trp Leu Ala Phe 20 25 30 Pro Leu Cys Ser Leu Tyr Leu Ile Ala Val Leu Gly Asn Leu Thr Ile 35 40 45 Ile Tyr Ile Val Arg Thr Glu His Ser Leu His Glu Pro Met Tyr Ile 50 55 60 Phe Leu Cys Met Leu Ser Gly Ile Asp Ile Leu Ile Ser Thr Ser Ser 65 70 75 80 Met Pro Lys Met Leu Ala Ile Phe Trp Phe Asn Ser Thr Thr Ile Gln 85 90 95 Phe Asp Ala Cys Leu Leu Gln Met Phe Ala Ile His Ser Leu Ser Gly 100 105 110 Met Glu Ser Thr Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala 115 120 125 Ile Cys His Pro Leu Arg His Ala Thr Val Leu Thr Leu Pro Arg Val 130 135 140 Thr Lys Ile Gly Val Ala Ala Val Val Arg Gly Ala Ala Leu Met Ala 145 150 155 160 Pro Leu Pro Val Phe Ile Lys Gln Leu Pro Phe Cys Arg Ser Asn Ile 165 170 175 Leu Ser His Ser Tyr Cys Leu His Gln Asp Val Met Lys Leu Ala Cys 180 185 190 Asp Asp Ile Arg Val Asn Val Val Tyr Gly Leu Ile Val Ile Ile Ser 195 200 205 Ala Ile Gly Leu Asp Ser Leu Leu Ile Ser Phe Ser Tyr Leu Leu Ile 210 215 220 Leu Lys Thr Val Leu Gly Leu Thr Arg Glu Ala Gln Ala Lys Ala Phe 225 230 235 240 Gly Thr Cys Val Ser His Val Cys Ala Val Phe Ile Phe Tyr Val Pro 245 250 255 Phe Ile Gly Leu Ser Met Val His Arg Phe Ser Lys Arg Arg Asp Ser 260 265 270 Pro Leu Pro Val Ile Leu Ala Asn Ile Tyr Leu Leu Val Pro Pro Val 275 280 285 Leu Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Glu Ile Arg Gln Arg 290 295 300 Ile Leu Arg Leu Phe His Val Ala Thr His Ala Ser Glu Pro 305 310 315 <210> 159 <211> 945 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(945) <400> 159 atg ctt ccc tct aat atc acc tca aca cat cca gct gtc ttt ttg ttg 48 Met Leu Pro Ser Asn Ile Thr Ser Thr His Pro Ala Val Phe Leu Leu 1 5 10 15 gta gga att cct ggt ttg gaa cac ctg cat gcc tgg atc tcc atc ccc 96 Val Gly Ile Pro Gly Leu Glu His Leu His Ala Trp Ile Ser Ile Pro 20 25 30 ttc tgc ttt gct tat act ctg gcc ctg cta ggc aac tgt acc ctt ctc 144 Phe Cys Phe Ala Tyr Thr Leu Ala Leu Leu Gly Asn Cys Thr Leu Leu 35 40 45 ttc att atc cag gct gat gca gcc ctc cat gaa ccc atg tac ctc ttt 192 Phe Ile Ile Gln Ala Asp Ala Ala Leu His Glu Pro Met Tyr Leu Phe 50 55 60 ctg gcc atg ttg gca acc att gac ttg gtt ctt tct tct aca acg ctg 240 Leu Ala Met Leu Ala Thr Ile Asp Leu Val Leu Ser Ser Thr Thr Leu 65 70 75 80 ccc aaa atg ctt gcc ata ttc tgg ttc agg gat cag gag atc aac ttc 288 Pro Lys Met Leu Ala Ile Phe Trp Phe Arg Asp Gln Glu Ile Asn Phe 85 90 95 ttt gcc tgt ctg gtc cag atg ttc ttc ctt cac tcc ttc tcc atc atg 336 Phe Ala Cys Leu Val Gln Met Phe Phe Leu His Ser Phe Ser Ile Met 100 105 110 gag tca gca gtg ctg ctg gcc atg gcc ttt gac cgc tat gtg gcc atc 384 Glu Ser Ala Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile 115 120 125 tgc aag cca ttg cac tac acg acg gtc ctg act ggg tcc ctc atc acc 432 Cys Lys Pro Leu His Tyr Thr Thr Val Leu Thr Gly Ser Leu Ile Thr 130 135 140 aag att ggc atg gct gct gtg gcc cgg gct gtg aca cta atg act cca 480 Lys Ile Gly Met Ala Ala Val Ala Arg Ala Val Thr Leu Met Thr Pro 145 150 155 160 ctc ccc ttc ctg ctc aga cgc ttc cac tac tgc cga ggc cca gtg att 528 Leu Pro Phe Leu Leu Arg Arg Phe His Tyr Cys Arg Gly Pro Val Ile 165 170 175 gcc cat tgc tac tgt gaa cac atg gct gtg gta agg ctg gcg tgt ggg 576 Ala His Cys Tyr Cys Glu His Met Ala Val Val Arg Leu Ala Cys Gly 180 185 190 gac act agc ttc aac aat atc tat ggc att gct gtg gcc atg ttt agt 624 Asp Thr Ser Phe Asn Asn Ile Tyr Gly Ile Ala Val Ala Met Phe Ser 195 200 205 gtg gtg ttg gac ctg ctc ttt gtt atc ctg tct tat gtc ttc atc ctt 672 Val Val Leu Asp Leu Leu Phe Val Ile Leu Ser Tyr Val Phe Ile Leu 210 215 220 cag gca gtt ctc cag ctt gcc tct cag gag gcc cgc tac aaa gca ttt 720 Gln Ala Val Leu Gln Leu Ala Ser Gln Glu Ala Arg Tyr Lys Ala Phe 225 230 235 240 ggg aca tgt gtg tct cac ata ggt gcc atc ctg tcc acc tac act cca 768 Gly Thr Cys Val Ser His Ile Gly Ala Ile Leu Ser Thr Tyr Thr Pro 245 250 255 gta gtc atc tct tca gtc atg cac cgt gta gcc cgc cat gct gcc cct 816 Val Val Ile Ser Ser Val Met His Arg Val Ala Arg His Ala Ala Pro 260 265 270 cgt gtc cac ata ctc ctt gct att ttc tat ctc ctt ttc cca ccc atg 864 Arg Val His Ile Leu Leu Ala Ile Phe Tyr Leu Leu Phe Pro Pro Met 275 280 285 gtc aat cct atc ata tat gga gtc aag acc aag cag att cgt gag tat 912 Val Asn Pro Ile Ile Tyr Gly Val Lys Thr Lys Gln Ile Arg Glu Tyr 290 295 300 gtg ctc agt cta ttc cag aga aag aac atg tag 945 Val Leu Ser Leu Phe Gln Arg Lys Asn Met 305 310 315 <210> 160 <211> 314 <212> PRT <213> Homo sapiens <400> 160 Met Leu Pro Ser Asn Ile Thr Ser Thr His Pro Ala Val Phe Leu Leu 1 5 10 15 Val Gly Ile Pro Gly Leu Glu His Leu His Ala Trp Ile Ser Ile Pro 20 25 30 Phe Cys Phe Ala Tyr Thr Leu Ala Leu Leu Gly Asn Cys Thr Leu Leu 35 40 45 Phe Ile Ile Gln Ala Asp Ala Ala Leu His Glu Pro Met Tyr Leu Phe 50 55 60 Leu Ala Met Leu Ala Thr Ile Asp Leu Val Leu Ser Ser Thr Thr Leu 65 70 75 80 Pro Lys Met Leu Ala Ile Phe Trp Phe Arg Asp Gln Glu Ile Asn Phe 85 90 95 Phe Ala Cys Leu Val Gln Met Phe Phe Leu His Ser Phe Ser Ile Met 100 105 110 Glu Ser Ala Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile 115 120 125 Cys Lys Pro Leu His Tyr Thr Thr Val Leu Thr Gly Ser Leu Ile Thr 130 135 140 Lys Ile Gly Met Ala Ala Val Ala Arg Ala Val Thr Leu Met Thr Pro 145 150 155 160 Leu Pro Phe Leu Leu Arg Arg Phe His Tyr Cys Arg Gly Pro Val Ile 165 170 175 Ala His Cys Tyr Cys Glu His Met Ala Val Val Arg Leu Ala Cys Gly 180 185 190 Asp Thr Ser Phe Asn Asn Ile Tyr Gly Ile Ala Val Ala Met Phe Ser 195 200 205 Val Val Leu Asp Leu Leu Phe Val Ile Leu Ser Tyr Val Phe Ile Leu 210 215 220 Gln Ala Val Leu Gln Leu Ala Ser Gln Glu Ala Arg Tyr Lys Ala Phe 225 230 235 240 Gly Thr Cys Val Ser His Ile Gly Ala Ile Leu Ser Thr Tyr Thr Pro 245 250 255 Val Val Ile Ser Ser Val Met His Arg Val Ala Arg His Ala Ala Pro 260 265 270 Arg Val His Ile Leu Leu Ala Ile Phe Tyr Leu Leu Phe Pro Pro Met 275 280 285 Val Asn Pro Ile Ile Tyr Gly Val Lys Thr Lys Gln Ile Arg Glu Tyr 290 295 300 Val Leu Ser Leu Phe Gln Arg Lys Asn Met 305 310 <210> 161 <211> 945 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(945) <400> 161 atg tca gcc tcc aat atc acc tta aca cat cca act gcc ttc ttg ttg 48 Met Ser Ala Ser Asn Ile Thr Leu Thr His Pro Thr Ala Phe Leu Leu 1 5 10 15 gtg ggg att cca ggc ctg gaa cac ctg cac atc tgg atc tcc atc cct 96 Val Gly Ile Pro Gly Leu Glu His Leu His Ile Trp Ile Ser Ile Pro 20 25 30 ttc tgc tta gca tat aca ctg gcc ctg ctt gga aac tgc act ctc ctt 144 Phe Cys Leu Ala Tyr Thr Leu Ala Leu Leu Gly Asn Cys Thr Leu Leu 35 40 45 ctc atc atc cag gct gat gca gcc ctc cat gaa ccc atg tac ctc ttt 192 Leu Ile Ile Gln Ala Asp Ala Ala Leu His Glu Pro Met Tyr Leu Phe 50 55 60 ctg gcc atg ttg gca gcc atc gac ctg gtc ctt tcc tcc tca gca ctg 240 Leu Ala Met Leu Ala Ala Ile Asp Leu Val Leu Ser Ser Ser Ala Leu 65 70 75 80 ccc aaa atg ctt gcc ata ttc tgg ttc agg gat cgg gag ata aac ttc 288 Pro Lys Met Leu Ala Ile Phe Trp Phe Arg Asp Arg Glu Ile Asn Phe 85 90 95 ttt gcc tgt ctg gcc cag atg ttc ttc ctt cac tcc ttc tcc atc atg 336 Phe Ala Cys Leu Ala Gln Met Phe Phe Leu His Ser Phe Ser Ile Met 100 105 110 gag tca gca gtg ctg ctg gcc atg gcc ttt gac cgc tat gtg gct atc 384 Glu Ser Ala Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile 115 120 125 tgc aag cca ctg cac tac acc aag gtc ctg act ggg tcc ctc atc acc 432 Cys Lys Pro Leu His Tyr Thr Lys Val Leu Thr Gly Ser Leu Ile Thr 130 135 140 aag att ggc atg gct gct gtg gcc cgg gct gtg aca cta atg act cca 480 Lys Ile Gly Met Ala Ala Val Ala Arg Ala Val Thr Leu Met Thr Pro 145 150 155 160 ctc ccc ttc ctg ctg aga tgt ttc cac tac tgc cga ggc cca gtg atc 528 Leu Pro Phe Leu Leu Arg Cys Phe His Tyr Cys Arg Gly Pro Val Ile 165 170 175 gct cac tgc tac tgt gaa cac atg gct gtg gtg agg ctg gcg tgt ggg 576 Ala His Cys Tyr Cys Glu His Met Ala Val Val Arg Leu Ala Cys Gly 180 185 190 gac act agc ttc aac aat atc tat ggc atc gct gtg gcc atg ttt att 624 Asp Thr Ser Phe Asn Asn Ile Tyr Gly Ile Ala Val Ala Met Phe Ile 195 200 205 gtg gtg ttg gac ctg ctc ctt gtt atc ctg tct tat atc ttt att ctt 672 Val Val Leu Asp Leu Leu Leu Val Ile Leu Ser Tyr Ile Phe Ile Leu 210 215 220 cag gca gtt cta ctg ctt gcc tct cag gag gcc cgc tac aag gca ttt 720 Gln Ala Val Leu Leu Leu Ala Ser Gln Glu Ala Arg Tyr Lys Ala Phe 225 230 235 240 ggg aca tgt gtc tct cat ata ggt gcc atc tta gcc ttc tac aca act 768 Gly Thr Cys Val Ser His Ile Gly Ala Ile Leu Ala Phe Tyr Thr Thr 245 250 255 gtg gtc atc tct tca gtc atg cac cgt gta gcc cgc cat gct gcc cct 816 Val Val Ile Ser Ser Val Met His Arg Val Ala Arg His Ala Ala Pro 260 265 270 cat gtc cac atc ctc ctt gcc aat ttc tat ctg ctc ttc cca ccc atg 864 His Val His Ile Leu Leu Ala Asn Phe Tyr Leu Leu Phe Pro Pro Met 275 280 285 gtc aat ccc ata atc tat ggt gtc aag acc aag caa atc cgt gag agc 912 Val Asn Pro Ile Ile Tyr Gly Val Lys Thr Lys Gln Ile Arg Glu Ser 290 295 300 atc ttg gga gta ttc cca aga aag gat atg tag 945 Ile Leu Gly Val Phe Pro Arg Lys Asp Met 305 310 315 <210> 162 <211> 314 <212> PRT <213> Homo sapiens <400> 162 Met Ser Ala Ser Asn Ile Thr Leu Thr His Pro Thr Ala Phe Leu Leu 1 5 10 15 Val Gly Ile Pro Gly Leu Glu His Leu His Ile Trp Ile Ser Ile Pro 20 25 30 Phe Cys Leu Ala Tyr Thr Leu Ala Leu Leu Gly Asn Cys Thr Leu Leu 35 40 45 Leu Ile Ile Gln Ala Asp Ala Ala Leu His Glu Pro Met Tyr Leu Phe 50 55 60 Leu Ala Met Leu Ala Ala Ile Asp Leu Val Leu Ser Ser Ser Ala Leu 65 70 75 80 Pro Lys Met Leu Ala Ile Phe Trp Phe Arg Asp Arg Glu Ile Asn Phe 85 90 95 Phe Ala Cys Leu Ala Gln Met Phe Phe Leu His Ser Phe Ser Ile Met 100 105 110 Glu Ser Ala Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile 115 120 125 Cys Lys Pro Leu His Tyr Thr Lys Val Leu Thr Gly Ser Leu Ile Thr 130 135 140 Lys Ile Gly Met Ala Ala Val Ala Arg Ala Val Thr Leu Met Thr Pro 145 150 155 160 Leu Pro Phe Leu Leu Arg Cys Phe His Tyr Cys Arg Gly Pro Val Ile 165 170 175 Ala His Cys Tyr Cys Glu His Met Ala Val Val Arg Leu Ala Cys Gly 180 185 190 Asp Thr Ser Phe Asn Asn Ile Tyr Gly Ile Ala Val Ala Met Phe Ile 195 200 205 Val Val Leu Asp Leu Leu Leu Val Ile Leu Ser Tyr Ile Phe Ile Leu 210 215 220 Gln Ala Val Leu Leu Leu Ala Ser Gln Glu Ala Arg Tyr Lys Ala Phe 225 230 235 240 Gly Thr Cys Val Ser His Ile Gly Ala Ile Leu Ala Phe Tyr Thr Thr 245 250 255 Val Val Ile Ser Ser Val Met His Arg Val Ala Arg His Ala Ala Pro 260 265 270 His Val His Ile Leu Leu Ala Asn Phe Tyr Leu Leu Phe Pro Pro Met 275 280 285 Val Asn Pro Ile Ile Tyr Gly Val Lys Thr Lys Gln Ile Arg Glu Ser 290 295 300 Ile Leu Gly Val Phe Pro Arg Lys Asp Met 305 310 <210> 163 <211> 963 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(963) <400> 163 atg gca gaa act cta caa ctc aat tcc acc ttc cta cac cca aac ttc 48 Met Ala Glu Thr Leu Gln Leu Asn Ser Thr Phe Leu His Pro Asn Phe 1 5 10 15 tt c ata ctg act ggc ttt cca ggg cta gga agt gcc cag act tgg ctg 96 Phe Ile Leu Thr Gly Phe Pro Gly Leu Gly Ser Ala Gln Thr Trp Leu 20 25 30 aca ctg gtc ttt ggg ccc att tat ctg ctg gcc ctg ctg ggc aat gga 144 Thr Leu Val Phe Gly Pro Ile Tyr Leu Leu Ala Leu Leu Gly Asn Gly 35 40 45 gca ctg ccg gca gtg gtg tgg ata gac tcc aca ctg cac cag ccc atg 192 Ala Leu Pro Ala Val Val Trp Ile Asp Ser Thr Leu His Gln Pro Met 50 55 60 ttt cta ctg ttg gcc atc ctg gca gcc aca gac ctg ggc tta gcc aca 240 Phe Leu Leu Leu Ala Ile Leu Ala Ala Thr Asp Leu Gly Leu Ala Thr 65 70 75 80 tct ata gcc cca ggg ttg ctg gct gtg ctg tgg ctt ggg ccc cga tct 288 Ser Ile Ala Pro Gly Leu Leu Ala Val Leu Trp Leu Gly Pro Arg Ser 85 90 95 gtg cca tat gct gtg tgc ctg gtc cag atg ttc ttt gta cat gca ctg 336 Val Pro Tyr Ala Val Cys Leu Val Gln Met Phe Phe Val His Ala Leu 100 105 110 act gcc atg gaa tca ggt gtg ctt ttg gcc atg gcc tgt gat cgt gct 384 Thr Ala Met Glu Ser Gly Val Leu Leu Ala Met Ala Cys Asp Arg Ala 115 120 125 gcg gca ata ggg cgt cca ctg cac tac cct gtc ctg gtc acc aaa gcc 432 Ala Ala Ile Gly Arg Pro Leu His Tyr Pro Val Leu Val Thr Lys Ala 130 135 140 tgt gtg ggt tat gca gcc ttg gcc ctg gca ctg aaa gct gtg gct att 480 Cys Val Gly Tyr Ala Ala Leu Ala Leu Ala Leu Lys Ala Val Ala Ile 145 150 155 160 gtt gta cct ttc cca ctg ctg gtg gca aag ttt gag cac ttc caa gcc 528 Val Val Pro Phe Pro Leu Leu Val Ala Lys Phe Glu His Phe Gln Ala 165 170 175 aag acc ata ggc cat acc tat tgt gca cac atg gca gtg gta gaa ctg 576 Lys Thr Ile Gly His Thr Tyr Cys Ala His Met Ala Val Val Glu Leu 180 185 190 gtg gtg ggt aac aca cag gcc acc aac tta tat ggt ctg gca ctt tca 624 Val Val Gly Asn Thr Gln Ala Thr Asn Leu Tyr Gly Leu Ala Leu Ser 195 200 205 ctg gcc atc tca ggt atg gat att ctg ggt atc act ggc tcc tat gga 672 Leu Ala Ile Ser Gly Met Asp Ile Leu Gly Ile Thr Gly Ser Tyr Gly 210 215 220 ctc att gcc cat gct gtg ctg cag cta cct acc cgg gag gcc cat gcc 720 Leu Ile Ala His Ala Val Leu Gln Leu Pro Thr Arg Glu Ala His Ala 225 230 235 240 aag gcc ttt ggt aca tgt agt tct cac atc tgt gtc att ctg gcc ttc 768 Lys Ala Phe Gly Thr Cys Ser Ser His Ile Cys Val Ile Leu Ala Phe 245 250 255 tac ata cct ggt ctc ttc tcc tac ctc aca cac cgc ttt ggt cat cac 816 Tyr Ile Pro Gly Leu Phe Ser Tyr Leu Thr His Arg Phe Gly His His 260 265 270 act gtc cca aag cct gtg cac atc ctt ctc tcc aac atc tac ttg ctg 864 Thr Val Pro Lys Pro Val His Ile Leu Leu Ser Asn Ile Tyr Leu Leu 275 280 285 ctg cca cct gcc ctc aac ccc ctc atc tat ggg gcc cgc acc aag cag 912 Leu Pro Pro Ala Leu Asn Pro Leu Ile Tyr Gly Ala Arg Thr Lys Gln 290 295 300 atc aga gac cga ctc ctg gaa acc ttc aca ttc aga aaa agc ccg ttg 960 Ile Arg Asp Arg Leu Leu Glu Thr Phe Thr Phe Arg Lys Ser Pro Leu 305 310 315 320 taa 963 <210> 164 <211> 320 <212> PRT <213> Homo sapiens <400> 164 Met Ala Glu Thr Leu Gln Leu Asn Ser Thr Phe Leu His Pro Asn Phe 1 5 10 15 Phe Ile Leu Thr Gly Phe Pro Gly Leu Gly Ser Ala Gln Thr Trp Leu 20 25 30 Thr Leu Val Phe Gly Pro Ile Tyr Leu Leu Ala Leu Leu Gly Asn Gly 35 40 45 Ala Leu Pro Ala Val Val Trp Ile Asp Ser Thr Leu His Gln Pro Met 50 55 60 Phe Leu Leu Leu Ala Ile Leu Ala Ala Thr Asp Leu Gly Leu Ala Thr 65 70 75 80 Ser Ile Ala Pro Gly Leu Leu Ala Val Leu Trp Leu Gly Pro Arg Ser 85 90 95 Val Pro Tyr Ala Val Cys Leu Val Gln Met Phe Phe Val His Ala Leu 100 105 110 Thr Ala Met Glu Ser Gly Val Leu Leu Ala Met Ala Cys Asp Arg Ala 115 120 125 Ala Ala Ile Gly Arg Pro Leu His Tyr Pro Val Leu Val Thr Lys Ala 130 135 140 Cys Val Gly Tyr Ala Ala Leu Ala Leu Ala Leu Lys Ala Val Ala Ile 145 150 155 160 Val Val Pro Phe Pro Leu Leu Val Ala Lys Phe Glu His Phe Gln Ala 165 170 175 Lys Thr Ile Gly His Thr Tyr Cys Ala His Met Ala Val Val Glu Leu 180 185 190 Val Val Gly Asn Thr Gln Ala Thr Asn Leu Tyr Gly Leu Ala Leu Ser 195 200 205 Leu Ala Ile Ser Gly Met Asp Ile Leu Gly Ile Thr Gly Ser Tyr Gly 210 215 220 Leu Ile Ala His Ala Val Leu Gln Leu Pro Thr Arg Glu Ala His Ala 225 230 235 240 Lys Ala Phe Gly Thr Cys Ser Ser His Ile Cys Val Ile Leu Ala Phe 245 250 255 Tyr Ile Pro Gly Leu Phe Ser Tyr Leu Thr His Arg Phe Gly His His 260 265 270 Thr Val Pro Lys Pro Val His Ile Leu Leu Ser Asn Ile Tyr Leu Leu 275 280 285 Leu Pro Pro Ala Leu Asn Pro Leu Ile Tyr Gly Ala Arg Thr Lys Gln 290 295 300 Ile Arg Asp Arg Leu Leu Glu Thr Phe Thr Phe Arg Lys Ser Pro Leu 305 310 315 320 <210> 165 <211> 813 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(813) <400> 165 atg ttc ttt agt ctt cat aga gag act cca aaa gaa ggc atg ttt ggt 48 Met Phe Phe Ser Leu His Arg Glu Thr Pro Lys Glu Gly Met Phe Gly 1 5 10 15 gct aat ctc acc acc ttc cat ccc act cta ttc att ctc ctt ggc atc 96 Ala Asn Leu Thr Thr Phe His Pro Thr Leu Phe Ile Leu Leu Gly Ile 20 25 30 cca gga ctg gag caa tac cac atc tgg ctt tcc att cct ttc tac ctt 144 Pro Gly Leu Glu Gln Tyr His Ile Trp Leu Ser Ile Pro Phe Tyr Leu 35 40 45 atg tac atc act gca gtc ttg gga aat gga gcc ctc atc cta gtt gtc 192 Met Tyr Ile Thr Ala Val Leu Gly Asn Gly Ala Leu Ile Leu Val Val 50 55 60 ctc agt gaa cac acc ctc cat gtc ttc cta tcc atg ctg gct ggc act 240 Leu Ser Glu His Thr Leu His Val Phe Leu Ser Met Leu Ala Gly Thr 65 70 75 80 gat atc ctg cta tcc acc acc act gtg cct aag gcc ttg gcg atc ttc 288 Asp Ile Leu Leu Ser Thr Thr Thr Val Pro Lys Ala Leu Ala Ile Phe 85 90 95 tgg gtc cac gct ggg gag ata gcc ttt gat gcc tgc att act cag atg 336 Trp Val His Ala Gly Glu Ile Ala Phe Asp Ala Cys Ile Thr Gln Met 100 105 110 ttt ttc att cat gtt gcc ttt gtg gct gag tca gga atc ctg ctg gcc 384 Phe Phe Ile His Val Ala Phe Val Ala Glu Ser Gly Ile Leu Leu Ala 115 120 125 atg gca ttt gac agt tat gta gcc att tgt act ccc ttg aga tac act 432 Met Ala Phe Asp Ser Tyr Val Ala Ile Cys Thr Pro Leu Arg Tyr Thr 130 135 140 acc atc tta act tct atg gta aat gga aaa atg acc ctg aca atc tgg 480 Thr Ile Leu Thr Ser Met Val Asn Gly Lys Met Thr Leu Thr Ile Trp 145 150 155 160 gga caa agc att ggg aca att ttt cct gtc ata ttc ctg ctg aag agg 528 Gly Gln Ser Ile Gly Thr Ile Phe Pro Val Ile Phe Leu Leu Lys Arg 165 170 175 ctg cca tac tgt cag acc aat atc atc ccc cac tca tac tgt gag cac 576 Leu Pro Tyr Cys Gln Thr Asn Ile Ile Pro His Ser Tyr Cys Glu His 180 185 190 att ggg gtg gcc caa ttg gcc tgt gct gac ata act gtc aat atc tgg 624 Ile Gly Val Ala Gln Leu Ala Cys Ala Asp Ile Thr Val Asn Ile Trp 195 200 205 tat ggc ttt tca gtg cca atg gca tcg gtt ttg gta gat gtt gca ttc 672 Tyr Gly Phe Ser Val Pro Met Ala Ser Val Leu Val Asp Val Ala Phe 210 215 220 att ggt ttt tcc tac act ttg atc ctc cag gct gtg ttt aga ctt cct 720 Ile Gly Phe Ser Tyr Thr Leu Ile Leu Gln Ala Val Phe Arg Leu Pro 225 230 235 240 tcc cag gag tcc cag cac aaa gct ctt aac acc tgt ggt tct aca ttg 768 Ser Gln Glu Ser Gln His Lys Ala Leu Asn Thr Cys Gly Ser Thr Leu 245 250 255 gag ttg ttc tcc tct tct tca tcc cat cat ttt tta ctt tcc tga 813 Glu Leu Phe Ser Ser Ser Ser Ser His His Phe Leu Leu Ser 260 265 270 <210> 166 <211> 270 <212> PRT <213> Homo sapiens <400> 166 Met Phe Phe Ser Leu His Arg Glu Thr Pro Lys Glu Gly Met Phe Gly 1 5 10 15 Ala Asn Leu Thr Thr Phe His Pro Thr Leu Phe Ile Leu Leu Gly Ile 20 25 30 Pro Gly Leu Glu Gln Tyr His Ile Trp Leu Ser Ile Pro Phe Tyr Leu 35 40 45 Met Tyr Ile Thr Ala Val Leu Gly Asn Gly Ala Leu Ile Leu Val Val 50 55 60 Leu Ser Glu His Thr Leu His Val Phe Leu Ser Met Leu Ala Gly Thr 65 70 75 80 Asp Ile Leu Leu Ser Thr Thr Thr Val Pro Lys Ala Leu Ala Ile Phe 85 90 95 Trp Val His Ala Gly Glu Ile Ala Phe Asp Ala Cys Ile Thr Gln Met 100 105 110 Phe Phe Ile His Val Ala Phe Val Ala Glu Ser Gly Ile Leu Leu Ala 115 120 125 Met Ala Phe Asp Ser Tyr Val Ala Ile Cys Thr Pro Leu Arg Tyr Thr 130 135 140 Thr Ile Leu Thr Ser Met Val Asn Gly Lys Met Thr Leu Thr Ile Trp 145 150 155 160 Gly Gln Ser Ile Gly Thr Ile Phe Pro Val Ile Phe Leu Leu Lys Arg 165 170 175 Leu Pro Tyr Cys Gln Thr Asn Ile Ile Pro His Ser Tyr Cys Glu His 180 185 190 Ile Gly Val Ala Gln Leu Ala Cys Ala Asp Ile Thr Val Asn Ile Trp 195 200 205 Tyr Gly Phe Ser Val Pro Met Ala Ser Val Leu Val Asp Val Ala Phe 210 215 220 Ile Gly Phe Ser Tyr Thr Leu Ile Leu Gln Ala Val Phe Arg Leu Pro 225 230 235 240 Ser Gln Glu Ser Gln His Lys Ala Leu Asn Thr Cys Gly Ser Thr Leu 245 250 255 Glu Leu Phe Ser Ser Ser Ser Ser His His Phe Leu Leu Ser 260 265 270 <210> 167 <211> 960 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(960) <400> 167 atg gat acc tcc acc agt gtt acc tat gac tcc agc ctc cag att tcc 48 Met Asp Thr Ser Thr Ser Val Thr Tyr Asp Ser Ser Leu Gln Ile Ser 1 5 10 15 cag ttc atc ctg atg gga tta cca ggc att cat gag tgg cag cac tgg 96 Gln Phe Ile Leu Met Gly Leu Pro Gly Ile His Glu Trp Gln His Trp 20 25 30 ctc tcc ctg ccc ctg act ctg ctc tac ctc tta gct ctt ggt gcc aac 144 Leu Ser Leu Pro Leu Thr Leu Leu Tyr Leu Leu Ala Leu Gly Ala Asn 35 40 45 ctc ctc atc ata atc acc att caa cat gag acc gtg cta cat gaa ccc 192 Leu Leu Ile Ile Ile Thr Ile Gln His Glu Thr Val Leu His Glu Pro 50 55 60 atg tac cat ttg ctg ggc ata tta gca gtg gtg gac att ggc ctg gcc 240 Met Tyr His Leu Leu Gly Ile Leu Ala Val Val Asp Ile Gly Leu Ala 65 70 75 80 acc acc atc atg ccc aag atc ctg gcc atc ttc tgg ttt gat gcc aag 288 Thr Thr Ile Met Pro Lys Ile Leu Ala Ile Phe Trp Phe Asp Ala Lys 85 90 95 gcc att agc ctc ccc atg tgt ttt gct cag atc tat gcc atc cac tgc 336 Ala Ile Ser Leu Pro Met Cys Phe Ala Gln Ile Tyr Ala Ile His Cys 100 105 110 ttc ttc tgc ata gag tca ggc atc ttt ctc tgc atg gca gta gac aga 384 Phe Phe Cys Ile Glu Ser Gly Ile Phe Leu Cys Met Ala Val Asp Arg 115 120 125 tac ata gcc atc tgt cgc cct ctt cag tac ccc tcc ata gtc act aaa 432 Tyr Ile Ala Ile Cys Arg Pro Leu Gln Tyr Pro Ser Ile Val Thr Lys 130 135 140 gct ttt gtc ttc aaa gcc aca ggg ttc atc atg ctc agg aat ggc ctg 480 Ala Phe Val Phe Lys Ala Thr Gly Phe Ile Met Leu Arg Asn Gly Leu 145 150 155 160 ttg acc atc cca gtg cct ata ctg gct gcc cag aga cac tac tgt tcc 528 Leu Thr Ile Pro Val Pro Ile Leu Ala Ala Gln Arg His Tyr Cys Ser 165 170 175 agg aat gaa atc gag cac tgc ctc tgc tct aac ttg ggg gtt atc agc 576 Arg Asn Glu Ile Glu His Cys Leu Cys Ser Asn Leu Gly Val Ile Ser 180 185 190 ctg gct tgt gat gac atc act gtg aac aaa ttt tac caa ctg atg cta 624 Leu Ala Cys Asp Asp Ile Thr Val Asn Lys Phe Tyr Gln Leu Met Leu 195 200 205 gca tgg gtc ttg gtt ggg agt gat atg gct ctg gta ttt tct tcc tat 672 Ala Trp Val Leu Val Gly Ser Asp Met Ala Leu Val Phe Ser Ser Tyr 210 215 220 gct gta atc ctt cac tct gtg ctg agg ctg aac tca gca gaa gca atg 720 Ala Val Ile Leu His Ser Val Leu Arg Leu Asn Ser Ala Glu Ala Met 225 230 235 240 tcc aag gct ctg agc act tgt agc tcc cac ctc atc ctc atc ctc ttc 768 Ser Lys Ala Leu Ser Thr Cys Ser Ser His Leu Ile Leu Ile Leu Phe 245 250 255 cac aca ggt atc att gtg ctg tct gtc aca cac ctt gca gag aaa aag 816 His Thr Gly Ile Ile Val Leu Ser Val Thr His Leu Ala Glu Lys Lys 260 265 270 att ccc ctt att cct gtg ttc ctt aat gtg ctg cac aat gtc atc ccc 864 Ile Pro Leu Ile Pro Val Phe Leu Asn Val Leu His Asn Val Ile Pro 275 280 285 cct gca ctc aac ccc ctg gcc tgt gca ctc agg atg cac aaa ctc aga 912 Pro Ala Leu Asn Pro Leu Ala Cys Ala Leu Arg Met His Lys Leu Arg 290 295 300 ctg ggc ttt cag aga ctg ctt gga ctg ggt cag gac gtg tcc aag taa 960 Leu Gly Phe Gln Arg Leu Leu Gly Leu Gly Gln Asp Val Ser Lys 305 310 315 320 <210> 168 <211> 319 <212> PRT <21 3> Homo sapiens <400> 168 Met Asp Thr Ser Thr Ser Val Thr Tyr Asp Ser Ser Leu Gln Ile Ser 1 5 10 15 Gln Phe Ile Leu Met Gly Leu Pro Gly Ile His Glu Trp Gln His Trp 20 25 30 Leu Ser Leu Pro Leu Thr Leu Leu Tyr Leu Leu Ala Leu Gly Ala Asn 35 40 45 Leu Leu Ile Ile Ile Thr Ile Gln His Glu Thr Val Leu His Glu Pro 50 55 60 Met Tyr His Leu Leu Gly Ile Leu Ala Val Val Asp Ile Gly Leu Ala 65 70 75 80 Thr Thr Ile Met Pro Lys Ile Leu Ala Ile Phe Trp Phe Asp Ala Lys 85 90 95 Ala Ile Ser Leu Pro Met Cys Phe Ala Gln Ile Tyr Ala Ile His Cys 100 105 110 Phe Phe Cys Ile Glu Ser Gly Ile Phe Leu Cys Met Ala Val Asp Arg 115 120 125 Tyr Ile Ala Ile Cys Arg Pro Leu Gln Tyr Pro Ser Ile Val Thr Lys 130 135 140 Ala Phe Val Phe Lys Ala Thr Gly Phe Ile Met Leu Arg Asn Gly Leu 145 150 155 160 Leu Thr Ile Pro Val Pro Ile Leu Ala Ala Gln Arg His Tyr Cys Ser 165 170 175 Arg Asn Glu Ile Glu His Cys Leu Cys Ser Asn Leu Gly Val Ile Ser 180 185 190 Leu Ala Cys Asp Asp Ile Thr Val Asn Lys Phe Tyr Gln Leu Met Leu 195 200 205 Ala Trp Val Leu Val Gly Ser Asp Met Ala Leu Val Phe Ser Ser Tyr 210 215 220 Ala Val Ile Leu His Ser Val Leu Arg Leu Asn Ser Ala Glu Ala Met 225 230 235 240 Ser Lys Ala Leu Ser Thr Cys Ser Ser His Leu Ile Leu Ile Leu Phe 245 250 255 His Thr Gly Ile Ile Val Leu Ser Val Thr His Leu Ala Glu Lys Lys 260 265 270 Ile Pro Leu Ile Pro Val Phe Leu Asn Val Leu His Asn Val Ile Pro 275 280 285 Pro Ala Leu Asn Pro Leu Ala Cys Ala Leu Arg Met His Lys Leu Arg 290 295 300 Leu Gly Phe Gln Arg Leu Leu Gly Leu Gly Gln Asp Val Ser Lys 305 310 315 <210> 169 <211> 867 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(867) <400> 169 atg gat att ggc ctg agt ata gcc aat agc tca ggg ttt caa ctg tct 48 Met Asp Ile Gly Leu Ser Ile Ala Asn Ser Ser Gly Phe Gln Leu Ser 1 5 10 15 gag ttc att ctg ata ggg ttc cca ggc att cat gag tgg cag cac tgg 96 Glu Phe Ile Leu Ile Gly Phe Pro Gly Ile His Glu Trp Gln His Trp 20 25 30 ctc tcc ctg ccc tta gct ctt ggt gcc aat ctc ctc atc ata atc acc 144 Leu Ser Leu Pro Leu Ala Leu Gly Ala Asn Leu Leu Ile Ile Ile Thr 35 40 45 att caa cat gag acc atg cta cat gaa ccc atg tac cat ttg ctg ggc 192 Ile Gln His Glu Thr Met Leu His Glu Pro Met Tyr His Leu Leu Gly 50 55 60 ata tta gca gtg gtg gac att ggc ctg gcc acc acc atc atg ccc aag 240 Ile Leu Ala Val Val Asp Ile Gly Leu Ala Thr Thr Ile Met Pro Lys 65 70 75 80 atc ctg gcc atc ttc tgg ttt gat gcc aag gcc atc agc ctc cct gag 288 Ile Leu Ala Ile Phe Trp Phe Asp Ala Lys Ala Ile Ser Leu Pro Glu 85 90 95 tgt ttt gct cag atc tat gcc atc cac tct ttc atg tgc atg gag tca 336 Cys Phe Ala Gln Ile Tyr Ala Ile His Ser Phe Met Cys Met Glu Ser 100 105 110 ggc atc ttc ctc tgc atg gca gtg gat aga tat atg gcc att tgt tat 384 Gly Ile Phe Leu Cys Met Ala Val Asp Arg Tyr Met Ala Ile Cys Tyr 115 120 125 ccc ctt cag tac act tcc ata gtt act gaa gct ttt gtc atc aaa gcc 432 Pro Leu Gln Tyr Thr Ser Ile Val Thr Glu Ala Phe Val Ile Lys Ala 130 135 140 aca ctg tca gta gtg ctc agg aat ggc ctg ttg acc atc cca gtg cca 480 Thr Leu Ser Val Val Leu Arg Asn Gly Leu Leu Thr Ile Pro Val Pro 145 150 155 160 gta ttg gct gcc cag cga cac tac tgc tcc agg aat gag att gat cag 528 Val Leu Ala Ala Gln Arg His Tyr Cys Ser Arg Asn Glu Ile Asp Gln 165 170 175 tgc ctc tgc tct aac ttg ggg gtc aca agt ctg gcc tgt gat gac acc 576 Cys Leu Cys Ser Asn Leu Gly Val Thr Ser Leu Ala Cys Asp Asp Thr 180 185 190 act att aac agg ttt tac cag ctg gcc ttg gtc tgg gtt gtg gtt ggg 624 Thr Ile Asn Arg Phe Tyr Gln Leu Ala Leu Val Trp Val Val Val Gly 195 200 205 agt gac atg ggt ctg gtc ttt gct tcc tat tct ttg att att cac tca 672 Ser Asp Met Gly Leu Val Phe Ala Ser Tyr Ser Leu Ile Ile His Ser 210 215 220 gtg ctg aag ctg aac tct gct aaa gca aca tct aag gcc ctg aat acc 720 Val Leu Lys Leu Asn Ser Ala Lys Ala Thr Ser Lys Ala Leu Asn Thr 225 230 235 240 tgc agc tct cac ctt atc ctc att ctc ttt ttc tac aca gct att att 768 Cys Ser Ser His Leu Ile Leu Ile Leu Phe Phe Tyr Thr Ala Ile Ile 245 250 255 gta gta tct gtc acc acc tgg cag gaa gaa ggg ctc ccc gca tcc ctg 816 Val Val Ser Val Thr Thr Trp Gln Glu Glu Gly Leu Pro Ala Ser Leu 260 265 270 ttc tcc tca atg tgc tgc ata ttg tca tcc cct cag ccc tta acc cca 864 Phe Ser Ser Met Cys Cys Ile Leu Ser Ser Pro Gln Pro Leu Thr Pro 275 280 285 tag 867 <210> 170 <211> 288 <212> PRT <213> Homo sapiens <400> 170 Met Asp Ile Gly Leu Ser Ile Ala Asn Ser Ser Gly Phe Gln Leu Ser 1 5 10 15 Glu Phe Ile Leu Ile Gly Phe Pro Gly Ile His Glu Trp Gln His Trp 20 25 30 Leu Ser Leu Pro Leu Ala Leu Gly Ala Asn Leu Leu Ile Ile Ile Thr 35 40 45 Ile Gln His Glu Thr Met Leu His Glu Pro Met Tyr His Leu Leu Gly 50 55 60 Ile Leu Ala Val Val Asp Ile Gly Leu Ala Thr Thr Ile Met Pro Lys 65 70 75 80 Ile Leu Ala Ile Phe Trp Phe Asp Ala Lys Ala Ile Ser Leu Pro Glu 85 90 95 Cys Phe Ala Gln Ile Tyr Ala Ile His Ser Phe Met Cys Met Glu Ser 100 105 110 Gly Ile Phe Leu Cys Met Ala Val Asp Arg Tyr Met Ala Ile Cys Tyr 115 120 125 Pro Leu Gln Tyr Thr Ser Ile Val Thr Glu Ala Phe Val Ile Lys Ala 130 135 140 Thr Leu Ser Val Val Leu Arg Asn Gly Leu Leu Thr Ile Pro Val Pro 145 150 155 160 Val Leu Ala Ala Gln Arg His Tyr Cys Ser Arg Asn Glu Ile Asp Gln 165 170 175 Cys Leu Cys Ser Asn Leu Gly Val Thr Ser Leu Ala Cys Asp Asp Thr 180 185 190 Thr Ile Asn Arg Phe Tyr Gln Leu Ala Leu Val Trp Val Val Val Gly 195 200 205 Ser Asp Met Gly Leu Val Phe Ala Ser Tyr Ser Leu Ile Ile His Ser 210 215 220 Val Leu Lys Leu Asn Ser Ala Lys Ala Thr Ser Lys Ala Leu Asn Thr 225 230 235 240 Cys Ser Ser His Leu Ile Leu Ile Leu Phe Phe Tyr Thr Ala Ile Ile 245 250 255 Val Val Ser Val Thr Thr Trp Gln Glu Glu Gly Leu Pro Ala Ser Leu 260 265 270 Phe Ser Ser Met Cys Cys Ile Leu Ser Ser Pro Gln Pro Leu Thr Pro 275 280 285 <210> 171 <211> 738 <212> DNA <21 3> Homo sapiens <220> <221> CDS <222> (1)..(738) <400> 171 atg tca gcc tcc agt atc acc tca aca cat cca act tcc ttc ttg ttg 48 Met Ser Ala Ser Ser Ile Thr Ser Thr His Pro Thr Ser Phe Leu Leu 1 5 10 15 atg ggg att cca ggc ctg gag cac ctg cac atc tgg atc tcc atc ccc 96 Met Gly Ile Pro Gly Leu Glu His Leu His Ile Trp Ile Ser Ile Pro 20 25 30 ttc tca gca tat aca ctg gcc ctg ctt gga aac tgc acc ctc ctt ctc 144 Phe Ser Ala Tyr Thr Leu Ala Leu Leu Gly Asn Cys Thr Leu Leu Leu 35 40 45 atc atc cag gct gat gca gcc ctc cat gag ccc ata tac ctc ttt ctg 192 Ile Ile Gln Ala Asp Ala Ala Leu His Glu Pro Ile Tyr Leu Phe Leu 50 55 60 gcc atg ttg gca gcc atc gac ctg gtc ctt tcc tcc tca gca ttg ccc 240 Ala Met Leu Ala Ala Ile Asp Leu Val Leu Ser Ser Ser Ala Leu Pro 65 70 75 80 aaa atg ctt gcc ata ttc tgg ttc agg gat cgg gag atc aac ttt ttt 288 Lys Met Leu Ala Ile Phe Trp Phe Arg Asp Arg Glu Ile Asn Phe Phe 85 90 95 gcc tgt ctg gtc cag atg ttc ttc ctt cac tcc ttc tcc atc atg gag 336 Ala Cys Leu Val Gln Met Phe Phe Leu His Ser Phe Ser Ile Met Glu 100 105 110 tca gca gtg ctg ctg gcc atg gcc ttt gac cgc tat gtg gcc atc tgc 384 Ser Ala Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys 115 120 125 aag cca ctg cac tac acc acg gtc ctg act ggg tcc ctc atc acc aag 432 Lys Pro Leu His Tyr Thr Thr Val Leu Thr Gly Ser Leu Ile Thr Lys 130 135 140 att ggc atg gct gct gtg gcc cgg gct gtg aca cta atg act cca ctc 480 Ile Gly Met Ala Ala Val Ala Arg Ala Val Thr Leu Met Thr Pro Leu 145 150 155 160 ccc ttc ctg ctg aga tgt ttc cac tac tgc cga ggc cca gtg att gcc 528 Pro Phe Leu Leu Arg Cys Phe His Tyr Cys Arg Gly Pro Val Ile Ala 165 170 175 cgc tgc tac tgt gaa cac atg gct gtg gtc agg ctg gct gtg gga aca 576 Arg Cys Tyr Cys Glu His Met Ala Val Val Arg Leu Ala Val Gly Thr 180 185 190 cta gct tca aca ata tct atg gca ttg ctg tgg cca tgt tta ttg gag 624 L eu Ala Ser Thr Ile Ser Met Ala Leu Leu Trp Pro Cys Leu Leu Glu 195 200 205 tgt tgg atc tat tct tta tca tcc tat ctt ata tct tta tcc ttc agg 672 Cys Trp Ile Tyr Ser Leu Ser Ser Tyr Leu Ile Ser Leu Ser Phe Arg 210 215 220 cag ttc tac aac tct cct ctc agg agg ccc gct aca aag cat ttg gga 720 Gln Phe Tyr Asn Ser Pro Leu Arg Arg Pro Ala Thr Lys His Leu Gly 225 230 235 240 cat gtg tct ctc aca tag 738 His Val Ser Leu Thr 245 <210> 172 <211> 245 <212> PRT <213> Homo sapiens <400> 172 Met Ser Ala Ser Ser Ile Thr Ser Thr His Pro Thr Ser Phe Leu Leu 1 5 10 15 Met Gly Ile Pro Gly Leu Glu His Leu His Ile Trp Ile Ser Ile Pro 20 25 30 Phe Ser Ala Tyr Thr Leu Ala Leu Leu Gly Asn Cys Thr Leu Leu Leu 35 40 45 Ile Ile Gln Ala Asp Ala Ala Leu His Glu Pro Ile Tyr Leu Phe Leu 50 55 60 Ala Met Leu Ala Ala Ile Asp Leu Val Leu Ser Ser Ser Ala Leu Pro 65 70 75 80 Lys Met Leu Ala Ile Phe Trp Phe Arg Asp Arg Glu Ile Asn Phe Phe 85 90 95 Ala Cys Leu Val Gln Met Phe Phe Leu His Ser Phe Ser Ile Met Glu 100 105 110 Ser Ala Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys 115 120 125 Lys Pro Leu His Tyr Thr Thr Val Leu Thr Gly Ser Leu Ile Thr Lys 130 135 140 Ile Gly Met Ala Ala Val Ala Arg Ala Val Thr Leu Met Thr Pro Leu 145 150 155 160 Pro Phe Leu Leu Arg Cys Phe His Tyr Cys Arg Gly Pro Val Ile Ala 165 170 175 Arg Cys Tyr Cys Glu His Met Ala Val Val Arg Leu Ala Val Gly Thr 180 185 190 Leu Ala Ser Thr Ile Ser Met Ala Leu Leu Trp Pro Cys Leu Leu Glu 195 200 205 Cys Trp Ile Tyr Ser Leu Ser Ser Tyr Leu Ile Ser Leu Ser Phe Arg 210 215 220 Gln Phe Tyr Asn Ser Pro Leu Arg Arg Pro Ala Thr Lys His Leu Gly 225 230 235 240 His Val Ser Leu Thr 245 <210> 173 <211> 615 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(615) <400> 173 atg gtt tta aag aca aaa tgc tgc aac gta gta cta aat cca tat cta 48 Met Val Leu Lys Thr Lys Cys Cys Asn Val Val Leu Asn Pro Tyr Leu 1 5 10 15 ctt tca att tct ttc ttt ctg ctt ttc ctt cct gac ctt cag cta ctg 96 Leu Ser Ile Ser Phe Phe Leu Leu Phe Leu Pro Asp Leu Gln Leu Leu 20 25 30 caa aag agt tgc tca tcc tct gta ctc cca cag cct ttg gtg tgt gtc 144 Gln Lys Ser Cys Ser Ser Ser Val Leu Pro Gln Pro Leu Val Cys Val 35 40 45 cta gcc tca gtg tta cta gag ata tat gtg ttc cag gtt ttt ctg act 192 Leu Ala Ser Val Leu Leu Glu Ile Tyr Val Phe Gln Val Phe Leu Thr 50 55 60 gtg tca agt gtt tta cat aaa gtt aga gtg gga gca ttt ggg aga ctg 240 Val Ser Ser Val Leu His Lys Val Arg Val Gly Ala Phe Gly Arg Leu 65 70 75 80 gca agt ctt ggc tgc ctc ccc cta tta ttt tat ggt gca agg aga aag 288 Ala Ser Leu Gly Cys Leu Pro Leu Leu Phe Tyr Gly Ala Arg Arg Lys 85 90 95 gaa act tcc ttg ata acc atg gca ggt ttc cat ttg act gcc tcc act 336 Glu Thr Ser Leu Ile Thr Met Ala Gly Phe His Leu Thr Ala Ser Thr 100 105 110 ttc ctt att cgg gct ttg cca ctc aat gcc cag cat gct tcc ctt gtc 384 Phe Leu Ile Arg Ala Leu Pro Leu Asn Ala Gln His Ala Ser Leu Val 115 120 125 gtc aga ctg tat gtc tgt gca ttc tct cat ggg ctt att cgc tgt gga 432 Val Arg Leu Tyr Val Cys Ala Phe Ser His Gly Leu Ile Arg Cys Gly 130 135 140 gtg cta ctg cat ctc aga aac tcc agc tac gcc ctc caa agg cag agc 480 Val Leu Leu His Leu Arg Asn Ser Ser Tyr Ala Leu Gln Arg Gln Ser 145 150 155 160 tct tca cat ctt ttt gtt gct att gtt gtt gtt tgt ttt cgc ata cct 528 Ser Ser His Leu Phe Val Ala Ile Val Val Val Cys Phe Arg Ile Pro 165 170 175 ctc gag cct agc act agt tct tcc att ctc atc ata ttt tta ttc aca 576 Leu Glu Pro Ser Thr Ser Ser Ser Ile Leu Ile Ile Phe Leu Phe Thr 180 185 190 gga ttt ttg tcc tac cta atc act cta cat atg ctc tga 615 Gly Phe Leu Ser Tyr Leu Ile Thr Leu His Met Leu 195 200 205 <210> 174 <211> 204 <212> PRT <213> Homo sapiens <400> 174 Met Val Leu Lys Thr Lys Cys Cys Asn Val Val Leu Asn Pro Tyr Leu 1 5 10 15 Leu Ser Ile Ser Phe Phe Leu Leu Phe Leu Pro Asp Leu Gln Leu Leu 20 25 30 Gln Lys Ser Cys Ser Ser Ser Val Leu Pro Gln Pro Leu Val Cys Val 35 40 45 Leu Ala Ser Val Leu Leu Glu Ile Tyr Val Phe Gln Val Phe Leu Thr 50 55 60 Val Ser Ser Val Leu His Lys Val Arg Val Gly Ala Phe Gly Arg Leu 65 70 75 80 Ala Ser Leu Gly Cys Leu Pro Leu Leu Phe Tyr Gly Ala Arg Arg Lys 85 90 95 Glu Thr Ser Leu Ile Thr Met Ala Gly Phe His Leu Thr Ala Ser Thr 100 105 110 Phe Leu Ile Arg Ala Leu Pro Leu Asn Ala Gln His Ala Ser Leu Val 115 120 125 Val Arg Leu Tyr Val Cys Ala Phe Ser His Gly Leu Ile Arg Cys Gly 130 135 140 Val Leu Leu His Leu Arg Asn Ser Ser Tyr Ala Leu Gln Arg Gln Ser 145 150 155 160 Ser Ser His Leu Phe Val Ala Ile Val Val Val Cys Phe Arg Ile Pro 165 170 175 Leu Glu Pro Ser Thr Ser Ser Ser Ile Leu Ile Ile Phe Leu Phe Thr 180 185 190 Gly Phe Leu Ser Tyr Leu Ile Thr Leu His Met Leu 195 200 <210> 175 <211> 765 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(765) <400> 175 atg ttc ttc ttt ctc tcc atg ctg gcc atg act gac ctc atc ttg tcc 48 Met Phe Phe Phe Leu Ser Met Leu Ala Met Thr Asp Leu Ile Leu Ser 1 5 10 15 aca gct ggt gtg cct aaa gca ctc agt atc ttt tgg cta ggg gct cgc 96 Thr Ala Gly Val Pro Lys Ala Leu Ser Ile Phe Trp Leu Gly Ala Arg 20 25 30 gaa atc aca ttc cca gga tgc ctt aca caa atg ttc ttc ctt cac tat 144 Glu Ile Thr Phe Pro Gly Cys Leu Thr Gln Met Phe Phe Leu His Tyr 35 40 45 aac ttt gtc ctg gat tca gcc att ctg atg gcc atg gca ttt gat cac 192 Asn Phe Val Leu Asp Ser Ala Ile Leu Met Ala Met Ala Phe Asp His 50 55 60 tat gta gct atc tgt tct ccc ttg aga tat acc acc atc ttg act ccc 240 Tyr Val Ala Ile Cys Ser Pro Leu Arg Tyr Thr Thr Ile Leu Thr Pro 65 70 75 80 aag acc atc atc aag agt gct atg ggc atc tcc ttt cga agc ttc tgc 288 Lys Thr Ile Ile Lys Ser Ala Met Gly Ile Ser Phe Arg Ser Phe Cys 85 90 95 atc atc ctg cca gat gta ttc ttg ctg aca tgc ctg cct ttc tgc agg 336 I le Ile Leu Pro Asp Val Phe Leu Leu Thr Cys Leu Pro Phe Cys Arg 100 105 110 aca cgc atc ata ccc cac aca tac tgt gag cat ata ggt gtt gcc cag 384 Thr Arg Ile Ile Pro His Thr Tyr Cys Glu His Ile Gly Val Ala Gln 115 120 125 ctc gcc tgt gct gat atc tcc atc aac ttc tgg tat ggc ttt tgt gtt 432 Leu Ala Cys Ala Asp Ile Ser Ile Asn Phe Trp Tyr Gly Phe Cys Val 130 135 140 ccc atc atg acg gtc atc tca gat gtg att ctc att gct gtt tcc tac 480 Pro Ile Met Thr Val Ile Ser Asp Val Ile Leu Ile Ala Val Ser Tyr 145 150 155 160 gca cac atc ctc tgt gct gtc ttt ggc ctt ccc tcc caa gat gcc tgc 528 Ala His Ile Leu Cys Ala Val Phe Gly Leu Pro Ser Gln Asp Ala Cys 165 170 175 cag aaa gcc ctc ggc act tgt ggt tct cat gtc tgt gtc atc ctc atg 576 Gln Lys Ala Leu Gly Thr Cys Gly Ser His Val Cys Val Ile Leu Met 180 185 190 ttt tat aca cct gcc ttt ttc tcc atc ctc gcc cat cgc ttt gga cac 624 Phe Tyr Thr Pro Ala Phe Phe Ser Ile Leu Ala His Arg Phe Gly His 195 200 205 aat gtc tct cgc acc ttc cac atc atg ttt gcc aat ctc tac att gtt 672 Asn Val Ser Arg Thr Phe His Ile Met Phe Ala Asn Leu Tyr Ile Val 210 215 220 atc cca cct gca ctc aac ccc atg gtt tac gga gtg aag acc aag cag 720 Ile Pro Pro Ala Leu Asn Pro Met Val Tyr Gly Val Lys Thr Lys Gln 225 230 235 240 atc aga gat aag gtt ata ctt ttg ttt tct aag ggt aca gga tga 765 Ile Arg Asp Lys Val Ile Leu Leu Phe Ser Lys Gly Thr Gly 245 250 255 <210> 176 <211> 254 <212> PRT <213> Homo sapiens <400> 176 Met Phe Phe Phe Leu Ser Met Leu Ala Met Thr Asp Leu Ile Leu Ser 1 5 10 15 Thr Ala Gly Val Pro Lys Ala Leu Ser Ile Phe Trp Leu Gly Ala Arg 20 25 30 Glu Ile Thr Phe Pro Gly Cys Leu Thr Gln Met Phe Phe Leu His Tyr 35 40 45 Asn Phe Val Leu Asp Ser Ala Ile Leu Met Ala Met Ala Phe Asp His 50 55 60 Tyr Val Ala Ile Cys Ser Pro Leu Arg Tyr Thr Thr Ile Leu Thr Pro 65 70 75 80 Lys Thr Ile Ile Lys Ser Ala Met Gly Ile Ser Phe Arg Ser Phe Cys 85 90 95 Ile Ile Leu Pro Asp Val Phe Leu Leu Thr Cys Leu Pro Phe Cys Arg 100 105 110 Thr Arg Ile Ile Pro His Thr Tyr Cys Glu His Ile Gly Val Ala Gln 115 120 125 Leu Ala Cys Ala Asp Ile Ser Ile Asn Phe Trp Tyr Gly Phe Cys Val 130 135 140 Pro Ile Met Thr Val Ile Ser Asp Val Ile Leu Ile Ala Val Ser Tyr 145 150 155 160 A la His Ile Leu Cys Ala Val Phe Gly Leu Pro Ser Gln Asp Ala Cys 165 170 175 Gln Lys Ala Leu Gly Thr Cys Gly Ser His Val Cys Val Ile Leu Met 180 185 190 Phe Tyr Thr Pro Ala Phe Phe Ser Ile Leu Ala His Arg Phe Gly His 195 200 205 Asn Val Ser Arg Thr Phe His Ile Met Phe Ala Asn Leu Tyr Ile Val 210 215 220 Ile Pro Pro Ala Leu Asn Pro Met Val Tyr Gly Val Lys Thr Lys Gln 225 230 235 240 Ile Arg Asp Lys Val Ile Leu Leu Phe Ser Lys Gly Thr Gly 245 250 <210> 177 <211> 939 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(939) <400> 177 atg ggg ttg ttc aat gtc act cac cct gca ttc ttc ctc ctg act ggt 48 Met Gly Leu Phe Asn Val Thr His Pro Ala Phe Phe Leu Leu Thr Gly 1 5 10 15 atc cct ggt ctg gag agc tct cac tcc tgg ctg tca ggg ccc ctc tgc 96 Ile Pro Gly Leu Glu Ser Ser His Ser Trp Leu Ser Gly Pro Leu Cys 20 25 30 gtg atg tat gct gtg gcc ctt ggg gga aat aca gtg atc ctg cag gct 144 Val Met Tyr Ala Val Ala Leu Gly Gly Asn Thr Val Ile Leu Gln Ala 35 40 45 gtg cga gtg gag ccc agc ctc cat gag ccc atg tac tac ttc ctg tcc 192 Val Arg Val Glu Pro Ser Leu His Glu Pro Met Tyr Tyr Phe Leu Ser 50 55 60 atg ttg tcc ttc agt gat gtg gcc ata tcc atg gcc aca ctg ccc act 240 Met Leu Ser Phe Ser Asp Val Ala Ile Ser Met Ala Thr Leu Pro Thr 65 70 75 80 gta ctc cga acc ttc tgc ctc aat gcc cgc aac atc act ttt gat gcc 288 Val Leu Arg Thr Phe Cys Leu Asn Ala Arg Asn Ile Thr Phe Asp Ala 85 90 95 tgt cta att cag atg ttt ctt att cac ttc ttc tcc atg atg gaa tca 336 Cys Leu Ile Gln Met Phe Leu Ile His Phe Phe Ser Met Met Glu Ser 100 105 110 g gt att ctg ctg gcc atg agt ttt gac cgc tat gtg gcc att tgt gac 384 Gly Ile Leu Leu Ala Met Ser Phe Asp Arg Tyr Val Ala Ile Cys Asp 115 120 125 ccc ttg cgc tat gca act gtg ctc acc act gaa gtc att gct gca atg 432 Pro Leu Arg Tyr Ala Thr Val Leu Thr Thr Glu Val Ile Ala Ala Met 130 135 140 ggt tta ggt gca gct gct cga agc ttc atc acc ctt ttc cct ctt ccc 480 Gly Leu Gly Ala Ala Ala Arg Ser Phe Ile Thr Leu Phe Pro Leu Pro 145 150 155 160 ttt ctt att aag agg ctg cct atc tgc aga tcc aat gtt ctt tct cac 528 Phe Leu Ile Lys Arg Leu Pro Ile Cys Arg Ser Asn Val Leu Ser His 165 170 175 tcc tac tgc ctg cac cca gac atg atg agg ctt gcc tgt gct gat atc 576 Ser Tyr Cys Leu His Pro Asp Met Met Arg Leu Ala Cys Ala Asp Ile 180 185 190 agt atc aac agc atc tat gga ctc ttt gtt ctt gta tcc acc ttt ggc 624 Ser Ile Asn Ser Ile Tyr Gly Leu Phe Val Leu Val Ser Thr Phe Gly 195 200 205 atg gac ctg ttt ttt atc ttc ctc tcc tat gtg ctc att ctg cgt tct 672 Met Asp Leu Phe Phe Ile Phe Leu Ser Tyr Val Leu Ile Leu Arg Ser 210 215 220 gtc atg gcc act gct tcc cgt gag gaa cgc ctc aaa gct ctc aac aca 720 Val Met Ala Thr Ala Ser Arg Glu Glu Arg Leu Lys Ala Leu Asn Thr 225 230 235 240 tgt gtg tca cat atc ctg gct gta ctt gca ttt tat gtg cca atg att 768 Cys Val Ser His Ile Leu Ala Val Leu Ala Phe Tyr Val Pro Met Ile 245 250 255 ggg gtc tcc aca gtg cac cgc ttt ggg aag cat gtc cca tgc tac ata 816 Gly Val Ser Thr Val His Arg Phe Gly Lys His Val Pro Cys Tyr Ile 260 265 270 cat gtc ctc atg tca aat gtg tac cta ttt gtg cct cct gtg ctc aac 864 His Val Leu Met Ser Asn Val Tyr Leu Phe Val Pro Pro Val Leu Asn 275 280 285 cct ctc att tat agc gcc aag aca aag gaa atc cgc cga gcc att ttc 912 Pro Leu Ile Tyr Ser Ala Lys Thr Lys Glu Ile Arg Arg Ala Ile Phe 290 295 300 cgc atg ttt cac cac atc aaa ata tga 939 Arg Met Phe His His Ile Lys Ile 305 310 <210> 178 <211> 312 <212> PRT <213> Homo sapiens <400> 178 Met Gly Leu Phe Asn Val Thr His Pro Ala Phe Phe Leu Leu Thr Gly 1 5 10 15 Ile Pro Gly Leu Glu Ser Ser His Ser Trp Leu Ser Gly Pro Leu Cys 20 25 30 Val Met Tyr Ala Val Ala Leu Gly Gly Asn Thr Val Ile Leu Gln Ala 35 40 45 Val Arg Val Glu Pro Ser Leu His Glu Pro Met Tyr Tyr Phe Leu Ser 50 55 60 Met Leu Ser Phe Ser Asp Val Ala Ile Ser Met Ala Thr Leu Pro Thr 65 70 75 80 Val Leu Arg Thr Phe Cys Leu Asn Ala Arg Asn Ile Thr Phe Asp Ala 85 90 95 Cys Leu Ile Gln Met Phe Leu Ile His Phe Phe Ser Met Met Glu Ser 100 105 110 Gly Ile Leu Leu Ala Met Ser Phe Asp Arg Tyr Val Ala Ile Cys Asp 115 120 125 Pro Leu Arg Tyr Ala Thr Val Leu Thr Thr Glu Val Ile Ala Ala Met 130 135 140 Gly Leu Gly Ala Ala Ala Arg Ser Phe Ile Thr Leu Phe Pro Leu Pro 145 150 155 160 Phe Leu Ile Lys Arg Leu Pro Ile Cys Arg Ser Asn Val Leu Ser His 165 170 175 Ser Tyr Cys Leu His Pro Asp Met Met Arg Leu Ala Cys Ala Asp Ile 180 185 190 Ser Ile Asn Ser Ile Tyr Gly Leu Phe Val Leu Val Ser Thr Phe Gly 195 200 205 Met Asp Leu Phe Phe Ile Phe Leu Ser Tyr Val Leu Ile Leu Arg Ser 210 215 220 Val Met Ala Thr Ala Ser Arg Glu Glu Arg Leu Lys Ala Leu Asn Thr 225 230 235 240 Cys Val Ser His Ile Leu Ala Val Leu Ala Phe Tyr Val Pro Met Ile 245 250 255 Gly Val Ser Thr Val His Arg Phe Gly Lys His Val Pro Cys Tyr Ile 260 265 270 His Val Leu Met Ser Asn Val Tyr Leu Phe Val Pro Pro Val Leu Asn 275 280 285 Pro Leu Ile Tyr Ser Ala Lys Thr Lys Glu Ile Arg Arg Ala Ile Phe 290 295 300 Arg Met Phe His His Ile Lys Ile 305 310 <210> 179 <211> 981 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(981) <400> 179 atg tca gtc caa tat tcg ctc agt cct caa ttc atg ctg cta tcc aac 48 Met Ser Val Gln Tyr Ser Leu Ser Pro Gln Phe Met Leu Leu Ser Asn 1 5 10 15 att act cag ttt agc ccc ata ttc tat ctc acc agc ttt cct gga ttg 96 Ile Thr Gln Phe Ser Pro Ile Phe Tyr Leu Thr Ser Phe Pro Gly Leu 20 25 30 gaa ggc atc aaa cac tgg att ttc atc ccc ttt ttc ttt atg tac atg 144 Glu Gly Ile Lys His Trp Ile Phe Ile Pro Phe Phe Phe Met Tyr Met 35 40 45 gtt gcc atc tca ggc aat tgt ttc att ctg atc att att aag acc aac 192 Val Ala Ile Ser Gly Asn Cys Phe Ile Leu Ile Ile Ile Lys Thr Asn 50 55 60 cct cgt ctg cac aca ccc atg tac tat cta cta tcc ttg ctg gcc ctc 240 Pro Arg Leu His Thr Pro Met Tyr Tyr Leu Leu Ser Leu Leu Ala Leu 65 70 75 80 act gac ctg ggg ctg tgt gtg tcc acg ttg ccc acc act atg ggg atc 288 Thr Asp Leu Gly Leu Cys Val Ser Thr Leu Pro Thr Thr Met Gly Ile 85 90 95 ttc tgg ttt aac tcc cag agt atc tac ttt gga gcg tgt caa atc cag 336 Phe Trp Phe Asn Ser Gln Ser Ile Tyr Phe Gly Ala Cys Gln Ile Gln 100 105 110 atg ttc tgc atc cac tct ttt tcc ttc atg gag tcc tca gtg ctc ctc 384 Met Phe Cys Ile His Ser Phe Ser Phe Met Glu Ser Ser Val Leu Leu 115 120 125 atg atg tcc ttt gac cgc ttt gtg gcc atc tgc cac cct ctg agg tat 432 Met Met Ser Phe Asp Arg Phe Val Ala Ile Cys His Pro Leu Arg Tyr 130 135 140 tcg gtc att atc act ggc cag caa gtg gtc aga gca ggc cta att gtc 480 Ser Val Ile Ile Thr Gly Gln Gln Val Val Arg Ala Gly Leu Ile Val 145 150 155 160 atc ttc cgg gga cct gtg gcc act atc cct att gtc ctc ctc ctg aag 528 Ile Phe Arg Gly Pro Val Ala Thr Ile Pro Ile Val Leu Leu Leu Lys 165 170 175 gct ttt ccc tac tgt gga tct gtg gtc ctc tcc cac tca ttt tgc ctg 576 Ala Phe Pro Tyr Cys Gly Ser Val Val Leu Ser His Ser Phe Cys Leu 180 185 190 cac cag gaa gtg ata cag ctg gcc tgc aca gat acc acc ttc aat aat 624 His Gln Glu Val Ile Gln Leu Ala Cys Thr Asp Thr Thr Phe Asn Asn 195 200 205 ctg tat gga ctg atg gtg gta gtt ttc act gtg atg ctg gac ctg gtg 672 Leu Tyr Gly Leu Met Val Val Val Phe Thr Val Met Leu Asp Leu Val 210 215 220 ctc atc gca ctg tcc tat gga ctc atc ctg cac aca gta gca ggc ctg 720 Leu Ile Ala Leu Ser Tyr Gly Leu Ile Leu His Thr Val Ala Gly Leu 225 230 235 240 gcc tcc caa gag gag cag cgc cgt gcc ttt cag aca tgc acc gct cat 768 Ala Ser Gln Glu Glu Gln Arg Arg Ala Phe Gln Thr Cys Thr Ala His 245 250 255 ctc tgt gct gtg cta gta ttc ttt gtg ccc atg atg ggg ctg tcc ctg 816 Leu Cys Ala Val Leu Val Phe Phe Val Pro Met Met Gly Leu Ser Leu 260 265 270 gtg cac cgt ttt ggg aag cat gcc cca cct gct att cat ctt ctt atg 864 Val His Arg Phe Gly Lys His Ala Pro Pro Ala Ile His Leu Leu Met 275 280 285 gcc aat gtc tac ctt ttt gtg cct ccc atg ctt aac cca atc ata tac 912 Ala Asn Val Tyr Leu Phe Val Pro Pro Met Leu Asn Pro Ile Ile Tyr 290 295 300 ag c att aag acc aag gag atc cac cgt gcc att atc aaa ctc cta ggt 960 Ser Ile Lys Thr Lys Glu Ile His Arg Ala Ile Ile Lys Leu Leu Gly 305 310 315 320 ctt aaa aag gcc agt aaa tga 981 Leu Lys Lys Ala Ser Lys 325 <210> 180 <211> 326 <212> PRT <213> Homo sapiens <400> 180 Met Ser Val Gln Tyr Ser Leu Ser Pro Gln Phe Met Leu Leu Ser Asn 1 5 10 15 Ile Thr Gln Phe Ser Pro Ile Phe Tyr Leu Thr Ser Phe Pro Gly Leu 20 25 30 Glu Gly Ile Lys His Trp Ile Phe Ile Pro Phe Phe Phe Met Tyr Met 35 40 45 Val Ala Ile Ser Gly Asn Cys Phe Ile Leu Ile Ile Ile Lys Thr Asn 50 55 60 Pro Arg Leu His Thr Pro Met Tyr Tyr Leu Leu Ser Leu Leu Ala Leu 65 70 75 80 Thr Asp Leu Gly Leu Cys Val Ser Thr Leu Pro Thr Thr Met Gly Ile 85 90 95 Phe Trp Phe Asn Ser Gln Ser Ile Tyr Phe Gly Ala Cys Gln Ile Gln 100 105 110 Met Phe Cys Ile His Ser Phe Ser Phe Met Glu Ser Ser Val Leu Leu 115 120 125 Met Met Ser Phe Asp Arg Phe Val Ala Ile Cys His Pro Leu Arg Tyr 130 135 140 Ser Val Ile Ile Thr Gly Gln Gln Val Val Arg Ala Gly Leu Ile Val 145 150 155 160 Ile Phe Arg Gly Pro Val Ala Thr Ile Pro Ile Val Leu Leu Leu Lys 165 170 175 Ala Phe Pro Tyr Cys Gly Ser Val Val Leu Ser His Ser Phe Cys Leu 180 185 190 His Gln Glu Val Ile Gln Leu Ala Cys Thr Asp Thr Thr Phe Asn Asn 195 200 205 Leu Tyr Gly Leu Met Val Val Val Phe Thr Val Met Leu Asp Leu Val 210 215 220 Leu Ile Ala Leu Ser Tyr Gly Leu Ile Leu His Thr Val Ala Gly Leu 225 230 235 240 Ala Ser Gln Glu Glu Gln Arg Arg Ala Phe Gln Thr Cys Thr Ala His 245 250 255 Leu Cys Ala Val Leu Val Phe Phe Val Pro Met Met Gly Leu Ser Leu 260 265 270 Val His Arg Phe Gly Lys His Ala Pro Pro Ala Ile His Leu Leu Met 275 280 285 Ala Asn Val Tyr Leu Phe Val Pro Pro Met Leu Asn Pro Ile Ile Tyr 290 295 300 Ser Ile Lys Thr Lys Glu Ile His Arg Ala Ile Ile Lys Leu Leu Gly 305 310 315 320 Leu Lys Lys Ala Ser Lys 325 <210> 181 <211> 954 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(954) <400> 181 atg tcc cag gtg act aac acc aca caa gaa ggc atc tac ttc atc ctc 48 Met Ser Gln Val Thr Asn Thr Thr Gln Glu Gly Ile Tyr Phe Ile Leu 1 5 10 15 acg gac atc cct gga ttt gag gcc tcc cac atc tgg atc tcc atc ccc 96 Thr Asp Ile Pro Gly Phe Glu Ala Ser His Ile Trp Ile Ser Ile Pro 20 25 30 gtc tgc tgt ctc tac acc atc tcc atc atg ggc aat acc acc atc ctc 144 Val Cys Cys Leu Tyr Thr Ile Ser Ile Met Gly Asn Thr Thr Ile Leu 35 40 45 act gtc att cgc aca gag cca tct gtc cac cag cgc atg tat ctg ttt 192 Thr Val Ile Arg Thr Glu Pro Ser Val His Gln Arg Met Tyr Leu Phe 50 55 60 ctc tcc atg ctg gcc ctg acg gac ctg ggt ctc acc ctc acc acc cta 240 Leu Ser Met Leu Ala Leu Thr Asp Leu Gly Leu Thr Leu Thr Thr Leu 65 70 75 80 ccc aca gtc atg cag ctt ctc tgg ttc aac gtt cgt aga atc agc tct 288 Pro Thr Val Met Gln Leu Leu Trp Phe Asn Val Arg Arg Ile Ser Ser 85 90 95 gag gcc tgt ttt gct cag ttt ttc ttc ctt cat gga ttc tcc ttt atg 336 Glu Ala Cys Phe Ala Gln Phe Phe Phe Leu His Gly Phe Ser Phe Met 100 105 110 gag tct tct gtc ctc ctg gct atg tcc gtt gac tgc tat gtg gcc atc 384 Glu Ser Ser Val Leu Leu Ala Met Ser Val Asp Cys Tyr Val Ala Ile 115 120 125 tgc tgt ccc ctc cat tat gcc tcc atc ctc acc aat gaa gtc att ggt 432 Cys Cys Pro Leu His Tyr Ala Ser Ile Leu Thr Asn Glu Val Ile Gly 130 135 140 aga act ggg tta gcc atc att tgc tgc tgt gtt ctg gcg gtt ctt ccc 480 Arg Thr Gly Leu Ala Ile Ile Cys Cys Cys Val Leu Ala Val Leu Pro 145 150 155 160 tcc ctt ttc tta ctc aag cga ctg cct ttc tgc cac tcc cac ctt ctc 528 Ser Leu Phe Leu Leu Lys Arg Leu Pro Phe Cys His Ser His Leu Leu 165 170 175 tct cgc tcc tat tgc ctc cac cag gat atg atc cgc ctg gtc tgt gct 576 Ser Arg Ser Tyr Cys Leu His Gln Asp Met Ile Arg Leu Val Cys Ala 180 185 190 gac atc agg ctc aac agc tgg tat gga ttt gct ctt gcc ttg ctc att 624 Asp Ile Arg Leu Asn Ser Trp Tyr Gly Phe Ala Leu Ala Leu Leu Ile 195 200 205 att atc gtg gat cct ctg ctc att gtg atc tcc tat aca ctt att ctg 672 Ile Ile Val Asp Pro Leu Leu Ile Val Ile Ser Tyr Thr Leu Ile Leu 210 215 220 aaa aat atc ttg ggc aca gcc acc tgg gct gag cga ctc cgt gcc ctc 720 Lys Asn Ile Leu Gly Thr Ala Thr Trp Ala Glu Arg Leu Arg Ala Leu 225 230 235 240 aat aac tgc ctg tcc cac att cta gct gtc ctg gtc ctc tac att ccc 768 Asn Asn Cys Leu Ser His Ile Leu Ala Val Leu Val Leu Tyr Ile Pro 245 250 255 atg gtt ggt gta tct atg act cat cgc ttt gcc aag cat gcc tct cca 816 Met Val Gly Val Ser Met Thr His Arg Phe Ala Lys His Ala Ser Pro 260 265 270 ctg gtc cat gtt atc atg gcc aat atc tac ctg ctg gca ccc ccg gtg 864 Leu Val His Val Ile Met Ala Asn Ile Tyr Leu Leu Ala Pro Pro Val 275 280 285 atg aac ccc atc att tac agt gta aag aac aag cag atc caa tgg gga 912 Met Asn Pro Ile Ile Tyr Ser Val Lys Asn Lys Gln Ile Gln Trp Gly 290 295 300 atg tta aat ttc ctt tcc ctc aaa aat atg cat tca aga tga 954 Met Leu Asn Phe Leu Ser Leu Lys Asn Met His Ser Arg 305 310 315 <210> 182 <211> 317 <212> PRT <213> Homo sapiens <400> 182 Met Ser Gln Val Thr Asn Thr Thr Gln Glu Gly Ile Tyr Phe Ile Leu 1 5 10 15 Thr Asp Ile Pro Gly Phe Glu Ala Ser His Ile Trp Ile Ser Ile Pro 20 25 30 Val Cys Cys Leu Tyr Thr Ile Ser Ile Met Gly Asn Thr Thr Ile Leu 35 40 45 Thr Val Ile Arg Thr Glu Pro Ser Val His Gln Arg Met Tyr Leu Phe 50 55 60 Leu Ser Met Leu Ala Leu Thr Asp Leu Gly Leu Thr Leu Thr Thr Leu 65 70 75 80 Pro Thr Val Met Gln Leu Leu Trp Phe Asn Val Arg Arg Ile Ser Ser 85 90 95 Glu Ala Cys Phe Ala Gln Phe Phe Phe Leu His Gly Phe Ser Phe Met 100 105 110 Glu Ser Ser Val Leu Leu Ala Met Ser Val Asp Cys Tyr Val Ala Ile 115 120 125 Cys Cys Pro Leu His Tyr Ala Ser Ile Leu Thr Asn Glu Val Ile Gly 130 135 140 Arg Thr Gly Leu Ala Ile Ile Cys Cys Cys Val Leu Ala Val Leu Pro 145 150 155 160 Ser Leu Phe Leu Leu Lys Arg Leu Pro Phe Cys His Ser His Leu Leu 165 170 175 Ser Arg Ser Tyr Cys Leu His Gln Asp Met Ile Arg Leu Val Cys Ala 180 185 190 Asp Ile Arg Leu Asn Ser Trp Tyr Gly Phe Ala Leu Ala Leu Leu Ile 195 200 205 Ile Ile Val Asp Pro Leu Leu Ile Val Ile Ser Tyr Thr Leu Ile Leu 210 215 220 Lys Asn Ile Leu Gly Thr Ala Thr Trp Ala Glu Arg Leu Arg Ala Leu 225 230 235 240 Asn Asn Cys Leu Ser His Ile Leu Ala Val Leu Val Leu Tyr Ile Pro 245 250 255 Met Val Gly Val Ser Met Thr His Arg Phe Ala Lys His Ala Ser Pro 260 265 270 Leu Val His Val Ile Met Ala Asn Ile Tyr Leu Leu Ala Pro Pro Val 275 280 285 Met Asn Pro Ile Ile Tyr Ser Val Lys Asn Lys Gln Ile Gln Trp Gly 290 295 300 Met Leu Asn Phe Leu Ser Leu Lys Asn Met His Ser Arg 305 310 315 <210> 183 <211> 945 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(945) <400> 183 atg ctg ggt ctc aat ggc acc ccc ttc cag cca gca aca ctc cag ctg 48 Met Leu Gly Leu Asn Gly Thr Pro Phe Gln Pro Ala Thr Leu Gln Leu 1 5 10 15 aca ggc att cct ggg ata caa aca ggc ctc acc tgg gtt gcc ctg att 96 Thr Gly Ile Pro Gly Ile Gln Thr Gly Leu Thr Trp Val Ala Leu Ile 20 25 30 ttc tgc atc ctc tac atg atc tcc att gta ggt aac ctc agc att ctc 144 Phe Cys Ile Leu Tyr Met Ile Ser Ile Val Gly Asn Leu Ser Ile Leu 35 40 45 act ctg gtg ttt tgg gag cct gct ctg cat cag ccc atg tac tac ttc 192 Thr Leu Val Phe Trp Glu Pro Ala Leu His Gln Pro Met Tyr Tyr Phe 50 55 60 ctc tct atg ctc gct ctc aat gat ctg gga gtg tcc ttt tct aca ctt 240 Leu Ser Met Leu Ala Leu Asn Asp Leu Gly Val Ser Phe Ser Thr Leu 65 70 75 80 ccc act gtg att tct act ttc tgc ttc aac tac aac cat gtt gcg ttt 288 Pro Thr Val Ile Ser Thr Phe Cys Phe Asn Tyr Asn His Val Ala Phe 85 90 95 aat gct tgc ctg gtc cag atg ttc ttc atc cac act ttc tcc ttc atg 336 Asn Ala Cys Leu Val Gln Met Phe Phe Ile His Thr Phe Ser Phe Met 100 105 110 gag tca ggc ata ctg ctg gcc atg agc ttg gat cgc ttt gtg gct att 384 Glu Ser Gly Ile Leu Leu Ala Met Ser Leu Asp Arg Phe Val Ala Ile 115 120 125 tgt tat cca tta cgc tat gtc act gtg ctc act cac aac cgt ata ttg 432 Cys Tyr Pro Leu Arg Tyr Val Thr Val Leu Thr His Asn Arg Ile Leu 130 135 140 gct atg ggt ctg ggc atc ctt acc aag agt ttc acc act ctc ttc cct 480 Ala Met Gly Leu Gly Ile Leu Thr Lys Ser Phe Thr Thr Leu Phe Pro 145 150 155 160 ttc cct ttt gtg gtg aaa cga ctg ccc ttc tgc aaa ggc aat gtt ttg 528 Phe Pro Phe Val Val Lys Arg Leu Pro Phe Cys Lys Gly Asn Val Leu 165 170 175 cat cac tcc tac tgt ctc cat cca gat ctc atg aaa gta gca tgt gga 576 His His Ser Tyr Cys Leu His Pro Asp Leu Met Lys Val Ala Cys Gly 180 185 190 gac atc cat gtt aac aac att tat ggg ctc ttg gtg atc att ttt acc 624 Asp Ile His Val Asn Asn Ile Tyr Gly Leu Leu Val Ile Ile Phe Thr 195 200 205 tat ggt atg gac tca act ttc atc ctg ctt tcc tac gca ttg atc ctg 672 T yr Gly Met Asp Ser Thr Phe Ile Leu Leu Ser Tyr Ala Leu Ile Leu 210 215 220 aga gcc atg ctg gtc atc ata tcc cag gaa cag cgg ctc aag gca ctc 720 Arg Ala Met Leu Val Ile Ile Ser Gln Glu Gln Arg Leu Lys Ala Leu 225 230 235 240 aac acc tgc atg tca cac atc tgt gca gtg ctg gcc ttt tat gtg ccc 768 Asn Thr Cys Met Ser His Ile Cys Ala Val Leu Ala Phe Tyr Val Pro 245 250 255 ata att gct gtc tcc atg att cac cgc ttc tgg aaa agt gct cca cct 816 Ile Ile Ala Val Ser Met Ile His Arg Phe Trp Lys Ser Ala Pro Pro 260 265 270 gtt gtt cat gtc atg atg tcc aat gtc tac ctg ttt gta cca ccc atg 864 Val Val His Val Met Met Ser Asn Val Tyr Leu Phe Val Pro Pro Met 275 280 285 ctc aac cct atc atc tac agt gtg aaa acc aag gag atc cgc aaa ggg 912 Leu Asn Pro Ile Ile Tyr Ser Val Lys Thr Lys Glu Ile Arg Lys Gly 290 295 300 att ctc aag ttc ttc cat aaa tcc cag gcc tga 945 Ile Leu Lys Phe Phe His Lys Ser Gln Ala 305 310 315 <210> 184 <211> 314 <212> PRT <213> Homo sapiens <400> 184 Met Leu Gly Leu Asn Gly Thr Pro Phe Gln Pro Ala Thr Leu Gln Leu 1 5 10 15 Thr Gly Ile Pro Gly Ile Gln Thr Gly Leu Thr Trp Val Ala Leu Ile 20 25 30 Phe Cys Ile Leu Tyr Met Ile Ser Ile Val Gly Asn Leu Ser Ile Leu 35 40 45 Thr Leu Val Phe Trp Glu Pro Ala Leu His Gln Pro Met Tyr Tyr Phe 50 55 60 Leu Ser Met Leu Ala Leu Asn Asp Leu Gly Val Ser Phe Ser Thr Leu 65 70 75 80 Pro Thr Val Ile Ser Thr Phe Cys Phe Asn Tyr Asn His Val Ala Phe 85 90 95 Asn Ala Cys Leu Val Gln Met Phe Phe Ile His Thr Phe Ser Phe Met 100 105 110 Glu Ser Gly Ile Leu Leu Ala Met Ser Leu Asp Arg Phe Val Ala Ile 115 120 125 Cys Tyr Pro Leu Arg Tyr Val Thr Val Leu Thr His Asn Arg Ile Leu 130 135 140 Ala Met Gly Leu Gly Ile Leu Thr Lys Ser Phe Thr Thr Leu Phe Pro 145 150 155 160 Phe Pro Phe Val Val Lys Arg Leu Pro Phe Cys Lys Gly Asn Val Leu 165 170 175 His His Ser Tyr Cys Leu His Pro Asp Leu Met Lys Val Ala Cys Gly 180 185 190 Asp Ile His Val Asn Asn Ile Tyr Gly Leu Leu Val Ile Ile Phe Thr 195 200 205 Tyr Gly Met Asp Ser Thr Phe Ile Leu Leu Ser Tyr Ala Leu Ile Leu 210 215 220 Arg Ala Met Leu Val Ile Ile Ser Gln Glu Gln Arg Leu Lys Ala Leu 225 230 235 240 Asn Thr Cys Met Ser His Ile Cys Ala Val Leu Ala Phe Tyr Val Pro 245 250 255 Ile Ile Ala Val Ser Met Ile His Arg Phe Trp Lys Ser Ala Pro Pro 260 265 270 Val Val His Val Met Met Ser Asn Val Tyr Leu Phe Val Pro Pro Met 275 280 285 Leu Asn Pro Ile Ile Tyr Ser Val Lys Thr Lys Glu Ile Arg Lys Gly 290 295 300 Ile Leu Lys Phe Phe His Lys Ser Gln Ala 305 310 <210> 185 <211> 975 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(975) <400> 185 atg cct cta ttt aat tca tta tgc tgg ttt cca aca att cat gtg act 48 Met Pro Leu Phe Asn Ser Leu Cys Trp Phe Pro Thr Ile His Val Thr 1 5 10 15 cct cca tct ttt att ctt aat gga ata cct ggt ctg gaa aga gta cat 96 Pro Pro Ser Phe Ile Leu Asn Gly Ile Pro Gly Leu Glu Arg Val His 20 25 30 gta tgg atc tcc ctc cca ctc tgc aca atg tac atc atc ttc ctt gtg 144 Val Trp Ile Ser Leu Pro Leu Cys Thr Met Tyr Ile Ile Phe Leu Val 35 40 45 ggg aat ctt ggt ctt gtg tac ctc att tat tat gag gag tcc tta cat 192 Gly Asn Leu Gly Leu Val Tyr Leu Ile Tyr Tyr Glu Glu Ser Leu His 50 55 60 cat ccg atg tat ttt ttt ttt ggc cat gct ctc tcc ctc att gac ctc 240 His Pro Met Tyr Phe Phe Phe Gly His Ala Leu Ser Leu Ile Asp Leu 65 70 75 80 ctt acc tgc acc acc act cta ccc aat gca ctc tgc atc ttc tgg ttc 288 Leu Thr Cys Thr Thr Thr Leu Pro Asn Ala Leu Cys Ile Phe Trp Phe 85 90 95 agt ctc aaa gaa att aac ttc aat gct tgc ttg gcc cag atg ttc ttt 336 Ser Leu Lys Glu Ile Asn Phe Asn Ala Cys Leu Ala Gln Met Phe Phe 100 105 110 gtt cat ggg ttc aca ggt gtg gag tct ggg gtg ctc atg ctc atg gct 384 Val His Gly Phe Thr Gly Val Glu Ser Gly Val Leu Met Leu Met Ala 115 120 125 cta gac cgc tat ata gcc att tgc tac cct ttg cgt tat gct acc aca 432 Leu Asp Arg Tyr Ile Ala Ile Cys Tyr Pro Leu Arg Tyr Ala Thr Thr 130 135 140 ctc acc aac cct atc att gcc aag gct gag ctt gcc acc ttc ctg agg 480 Leu Thr Asn Pro Ile Ile Ala Lys Ala Glu Leu Ala Thr Phe Leu Arg 145 150 155 160 ggt gta ttg ctg atg att cct ttc cca ttc ttg gtt aag cgt ttg cct 528 Gly Val Leu Leu Met Ile Pro Phe Pro Phe Leu Val Lys Arg Leu Pro 165 170 175 ttc tgc caa agc aat att atc tcc cat acg tac tgc gac cac atg tct 576 Phe Cys Gln Ser Asn Ile Ile Ser His Thr Tyr Cys Asp His Met Ser 180 185 190 gta gta aag cta tct tgt gcc agc atc aag gtc aat gta atc tat ggt 624 Val Val Lys Leu Ser Cys Ala Ser Ile Lys Val Asn Val Ile Tyr Gly 195 200 205 cta atg gtt gct ctc ctg att gga gtg ttt gac att tgt tgt ata tct 672 Leu Met Val Ala Leu Leu Ile Gly Val Phe Asp Ile Cys Cys Ile Ser 210 215 220 ttg tct tac act ttg atc ctc aag gca gcg atc agc ctc tct tca tca 720 Leu Ser Tyr Thr Leu Ile Leu Lys Ala Ala Ile Ser Leu Ser Ser Ser 225 230 235 240 gat gct cgg cag aag gct ttc agc acc tgc act gcc cat ata tct gcc 768 Asp Ala Arg Gln Lys Ala Phe Ser Thr Cys Thr Ala His Ile Ser Ala 245 250 255 atc atc atc acc tat gtt cca gca ttc ttc act ttc ttt gcc cac cgt 816 Ile Ile Ile Thr Tyr Val Pro Ala Phe Phe Thr Phe Phe Ala His Arg 260 265 270 ttt ggg gga cac aca att ccc cct tct ctt cac atc att gtg gct aat 864 Phe Gly Gly His Thr Ile Pro Pro Ser Leu His Ile Ile Val Ala Asn 275 280 285 ctt tat ctt ctt ctt ccc cca act cta aac cct att gtt tat gga gta 912 Leu Tyr Leu Leu Leu Pro Pro Thr Leu Asn Pro Ile Val Tyr Gly Val 290 295 300 aag aca aaa cag ata cgc aag agt gtc ata aag ttc ttc cag ggt gat 960 Lys Thr Lys Gln Ile Arg Lys Ser Val Ile Lys Phe Phe Gln Gly Asp 305 310 315 320 aag ggt gca ggt tga 975 Lys Gly Ala Gly 325 <210> 186 <211> 324 <212> PRT <213> Homo sapiens <400> 186 Met Pro Leu Phe Asn Ser Leu Cys Trp Phe Pro Thr Ile His Val Thr 1 5 10 15 Pro Pro Ser Phe Ile Leu Asn Gly Ile Pro Gly Leu Glu Arg Val His 20 25 30 Val Trp Ile Ser Leu Pro Leu Cys Thr Met Tyr Ile Ile Phe Leu Val 35 40 45 Gly Asn Leu Gly Leu Val Tyr Leu Ile Tyr Tyr Glu Glu Ser Leu His 50 55 60 His Pro Met Tyr Phe Phe Phe Gly His Ala Leu Ser Leu Ile Asp Leu 65 70 75 80 Leu Thr Cys Thr Thr Thr Leu Pro Asn Ala Leu Cys Ile Phe Trp Phe 85 90 95 Ser Leu Lys Glu Ile Asn Phe Asn Ala Cys Leu Ala Gln Met Phe Phe 100 105 110 Val His Gly Phe Thr Gly Val Glu Ser Gly Val Leu Met Leu Met Ala 115 120 125 Leu Asp Arg Tyr Ile Ala Ile Cys Tyr Pro Leu Arg Tyr Ala Thr Thr 130 135 140 Leu Thr Asn Pro Ile Ile Ala Lys Ala Glu Leu Ala Thr Phe Leu Arg 145 150 155 160 Gly Val Leu Leu Met Ile Pro Phe Pro Phe Leu Val Lys Arg Leu Pro 165 170 175 Phe Cys Gln Ser Asn Ile Ile Ser His Thr Tyr Cys Asp His Met Ser 180 185 190 Val Val Lys Leu Ser Cys Ala Ser Ile Lys Val Asn Val Ile Tyr Gly 195 200 205 Leu Met Val Ala Leu Leu Ile Gly Val Phe Asp Ile Cys Cys Ile Ser 210 215 220 Leu Ser Tyr Thr Leu Ile Leu Lys Ala Ala Ile Ser Leu Ser Ser Ser 225 230 235 240 Asp Ala Arg Gln Lys Ala Phe Ser Thr Cys Thr Ala His Ile Ser Ala 245 250 255 Ile Ile Ile Thr Tyr Val Pro Ala Phe Phe Thr Phe Phe Ala His Arg 260 265 270 Phe Gly Gly His Thr Ile Pro Pro Ser Leu His Ile Ile Val Ala Asn 275 280 285 Leu Tyr Leu Leu Leu Pro Pro Thr Leu Asn Pro Ile Val Tyr Gly Val 290 295 300 Lys Thr Lys Gln Ile Arg Lys Ser Val Ile Lys Phe Phe Gln Gly Asp 305 310 315 320 Lys Gly Ala Gly <210> 187 <211> 975 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(975) <400> 187 atg aat cat atg tct gca tct ctc aaa atc tcc aat agc tcc aaa ttc 48 Met Asn His Met Ser Ala Ser Leu Lys Ile Ser Asn Ser Ser Lys Phe 1 5 10 15 cag gtc tct gag ttc atc ctg ctg gga ttc ccg ggc att cac agc tgg 96 Gln Val Ser Glu Phe Ile Leu Leu Gly Phe Pro Gly Ile His Ser Trp 20 25 30 caa cac tgg cta tct ctg ccc ctg gca cta ctg tat ctc tca gca ctt 144 Gln His Trp Leu Ser Leu Pro Leu Ala Leu Leu Tyr Leu Ser Ala Leu 35 40 45 gct gca aac acc ctc atc ctc atc atc atc tgg cag aac cct tct tta 192 Ala Ala Asn Thr Leu Ile Leu Ile Ile Ile Trp Gln Asn Pro Ser Leu 50 55 60 cag cag ccc atg tat att ttc ctt ggc atc ctc tgt atg gta gac atg 240 Gln Gln Pro Met Tyr Ile Phe Leu Gly Ile Leu Cys Met Val Asp Met 65 70 75 80 ggt ctg gcc act act atc atc cct aag atc ctg gcc atc ttc tgg ttt 288 Gly Leu Ala Thr Thr Ile Ile Pro Lys Ile Leu Ala Ile Phe Trp Phe 85 90 95 gat gcc aag gtt att agc ctc cct gag tgc ttt gct cag att tat gcc 336 Asp Ala Lys Val Ile Ser Leu Pro Glu Cys Phe Ala Gln Ile Tyr Ala 100 105 110 att cac ttc ttt gtg ggc atg gag tct ggt atc cta ctc tgc atg gct 384 Ile His Phe Phe Val Gly Met Glu Ser Gly Ile Leu Leu Cys Met Ala 115 120 125 ttt gat aga tat gtg gct att tgt cac cct ctt cgc tat cca tca att 432 Phe Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr Pro Ser Ile 130 135 140 gtc acc agt tcc tta atc tta aaa gct acc ctg ttc atg gtg ctg aga 480 Val Thr Ser Ser Leu Ile Leu Lys Ala Thr Leu Phe Met Val Leu Arg 145 150 155 160 aat ggc tta ttt gtc act cca gtg cct gtg ctt gca gca cag cgt gat 528 Asn Gly Leu Phe Val Thr Pro Val Pro Val Leu Ala Ala Gln Arg Asp 165 170 175 tat tgc tcc aag aat gaa att gaa cac tgc ctg tgc tct aac ctt ggg 576 Tyr Cys Ser Lys Asn Glu Ile Glu His Cys Leu Cys Ser Asn Leu Gly 180 185 190 gtc aca agc ctg gct tgt gat gac agg agg cca aac agc att tgc cag 624 Val Thr Ser Leu Ala Cys Asp Asp Arg Arg Pro Asn Ser Ile Cys Gln 195 200 205 ttg gtt ctg gca tgg ctt gga atg ggg agt gat cta agt ctt att ata 672 Leu Val Leu Ala Trp Leu Gly Met Gly Ser Asp Leu Ser Leu Ile Ile 210 215 220 ctg tca tat att ttg att ctg tac tct gta ctt aga ctg aac tca gct 720 Leu Ser Tyr Ile Leu Ile Leu Tyr Ser Val Leu Arg Leu Asn Ser Ala 225 230 235 240 gaa gct gca gcc aag gcc ctg agc act tgt agt tca cat ctc acc ctc 768 Glu Ala Ala Ala Lys Ala Leu Ser Thr Cys Ser Ser His Leu Thr Leu 245 250 255 atc ctt ttc ttt tac act att gtt gta gtg att tca gtg act cat ctg 816 Ile Leu Phe Phe Tyr Thr Ile Val Val Val Ile Ser Val Thr His Leu 260 265 270 aca gag atg aag gct act ttg att cca gtt cta ctt aat gtg ttg cac 864 Thr Glu Met Lys Ala Thr Leu Ile Pro Val Leu Leu Asn Val Leu His 275 280 285 aac atc atc ccc cct tcc ctc aac cct aca gtt tat gca ctt cag acc 912 Asn Ile Ile Pro Pro Ser Leu Asn Pro Thr Val Tyr Ala Leu Gln Thr 290 295 300 aaa gaa ctt agg gca gcc ttc caa aag gtg ctg ttt gcc ctt aca aaa 960 Lys Glu Leu Arg Ala Ala Phe Gln Lys Val Leu Phe Ala Leu Thr Lys 305 310 315 320 gaa ata aga tct tag 975 Glu Ile Arg Ser 325 <210> 188 <211> 324 <212> PRT <213> Homo sapiens <400> 188 Met Asn His Met Ser Ala Ser Leu Lys Ile Ser Asn Ser Ser Lys Phe 1 5 10 15 Gln Val Ser Glu Phe Ile Leu Leu Gly Phe Pro Gly Ile His Ser Trp 20 25 30 Gln His Trp Leu Ser Leu Pro Leu Ala Leu Leu Tyr Leu Ser Ala Leu 35 40 45 Ala Ala Asn Thr Leu Ile Leu Ile Ile Ile Trp Gln Asn Pro Ser Leu 50 55 60 Gln Gln Pro Met Tyr Ile Phe Leu Gly Ile Leu Cys Met Val Asp Met 65 70 75 80 Gly Leu Ala Thr Thr Ile Ile Pro Lys Ile Leu Ala Ile Phe Trp Phe 85 90 95 Asp Ala Lys Val Ile Ser Leu Pro Glu Cys Phe Ala Gln Ile Tyr Ala 100 105 110 Ile His Phe Phe Val Gly Met Glu Ser Gly Ile Leu Leu Cys Met Ala 115 120 125 Phe Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr Pro Ser Ile 130 135 140 Val Thr Ser Ser Leu Ile Leu Lys Ala Thr Leu Phe Met Val Leu Arg 145 150 155 160 Asn Gly Leu Phe Val Thr Pro Val Pro Val Leu Ala Ala Gln Arg Asp 165 170 175 Tyr Cys Ser Lys Asn Glu Ile Glu His Cys Leu Cys Ser Asn Leu Gly 180 185 190 Val Thr Ser Leu Ala Cys Asp Asp Arg Arg Pro Asn Ser Ile Cys Gln 195 200 205 Leu Val Leu Ala Trp Leu Gly Met Gly Ser Asp Leu Ser Leu Ile Ile 210 215 220 Leu Ser Tyr Ile Leu Ile Leu Tyr Ser Val Leu Arg Leu Asn Ser Ala 225 230 235 240 Glu Ala Ala Ala Lys Ala Leu Ser Thr Cys Ser Ser His Leu Thr Leu 245 250 255 Ile Leu Phe Phe Tyr Thr Ile Val Val Val Ile Ser Val Thr His Leu 260 265 270 Thr Glu Met Lys Ala Thr Leu Ile Pro Val Leu Leu Asn Val Leu His 275 280 285 Asn Ile Ile Pro Pro Ser Leu Asn Pro Thr Val Tyr Ala Leu Gln Thr 290 295 300 Lys Glu Leu Arg Ala Ala Phe Gln Lys Val Leu Phe Ala Leu Thr Lys 305 310 315 320 Glu Ile Arg Ser <210> 189 <211> 966 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(966) <400> 189 atg cta aca ctg aat aaa aca gac cta ata cca gct tca ttt att ctg 48 Met Leu Thr Leu Asn Lys Thr Asp Leu Ile Pro Ala Ser Phe Ile Leu 1 5 10 15 aat gga gtc cca gga ctg gaa gac aca caa ctc tgg att tcc ttc cca 96 Asn Gly Val Pro Gly Leu Glu Asp Thr Gln Leu Trp Ile Ser Phe Pro 20 25 30 ttc tgc tct atg tat gtt gtg gct atg gta ggg aat tgt gga ctc ctc 144 Phe Cys Ser Met Tyr Val Val Ala Met Val Gly Asn Cys Gly Leu Leu 35 40 45 tac ctc att cac tat gag gat gcc ctg cac aaa ccc atg tac tac ttc 192 Tyr Leu Ile His Tyr Glu Asp Ala Leu His Lys Pro Met Tyr Tyr Phe 50 55 60 ttg gcc atg ctt tcc ttt act gac ctt gtt atg tgc tct agt aca atc 240 Leu Ala Met Leu Ser Phe Thr Asp Leu Val Met Cys Ser Ser Thr Ile 65 70 75 80 cct aaa gcc ctc tgc atc ttc tgg ttt cat ctc aag gac att gga ttt 288 Pro Lys Ala Leu Cys Ile Phe Trp Phe His Leu Lys Asp Ile Gly Phe 85 90 95 gat gaa tgc ctt gtc cag atg ttc ttc atc cac acc ttc aca ggg atg 336 Asp Glu Cys Leu Val Gln Met Phe Phe Ile His Thr Phe Thr Gly Met 100 105 110 gag tct ggg gtg ctt atg ctt atg gcc ctg gat cgc tat gtg gcc atc 384 Glu Ser Gly Val Leu Met Leu Met Ala Leu Asp Arg Tyr Val Ala Ile 115 120 125 tgc tac ccc tta cgc tat tca act atc ctc acc aat cct gta att gca 432 Cys Tyr Pro Leu Arg Tyr Ser Thr Ile Leu Thr Asn Pro Val Ile Ala 130 135 140 aag gtt ggg act gcc acc ttc ctg aga ggg gta tta ctc att att ccc 480 Lys Val Gly Thr Ala Thr Phe Leu Arg Gly Val Leu Leu Ile Ile Pro 145 150 155 160 ttt act ttc ctc acc aag cgc ctg ccc tac tgc aga ggc aat ata ctt 528 Phe Thr Phe Leu Thr Lys Arg Leu Pro Tyr Cys Arg Gly Asn Ile Leu 165 170 175 ccc cat acc tac tgt gac cac atg tct gta gcc aaa ttg tcc tgt ggt 576 Pro His Thr Tyr Cys Asp His Met Ser Val Ala Lys Leu Ser Cys Gly 180 185 190 aat gtc aag gtc aat gcc atc tat ggt ctg atg gtt gcc ctc ctg att 624 Asn Val Lys Val Asn Ala Ile Tyr Gly Leu Met Val Ala Leu Leu Ile 195 200 205 ggg ggc ttt gac ata ctg tgt atc acc atc tcc tat acc atg att ctc 672 Gly Gly Phe Asp Ile Leu Cys Ile Thr Ile Ser Tyr Thr Met Ile Leu 210 215 220 cgg gca gtg gtc agc ctc tcc tca gca gat gct cgg cag aag gcc ttt 720 Arg Ala Val Val Ser Leu Ser Ser Ala Asp Ala Arg Gln Lys Ala Phe 225 230 235 240 aat acc tgc act gcc cac att tgt gcc att gtt ttc tcc tat act cca 768 Asn Thr Cys Thr Ala His Ile Cys Ala Ile Val Phe Ser Tyr Thr Pro 245 250 255 gct ttc ttc tcc ttc ttt tcc cac cgc ttt ggg gaa cac ata atc ccc 816 Ala Phe Phe Ser Phe Phe Ser His Arg Phe Gly Glu His Ile Ile Pro 260 265 270 cct tct tgc cac atc att gta gcc aat att tat ctg ctc cta cca ccc 864 Pro Ser Cys His Ile Ile Val Ala Asn Ile Tyr Leu Leu Leu Pro Pro 275 280 285 act atg aac cct att gtc tat ggg gtg aaa acc aaa cag ata cga gac 912 Thr Met Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Gln Ile Arg Asp 290 295 300 tgt gtc ata agg atc ctt tca ggt tct aag gat acc aaa tcc tac agc 960 Cys Val Ile Arg Ile Leu Ser Gly Ser Lys Asp Thr Lys Ser Tyr Ser 305 310 315 320 atg tga 966 Met <210> 190 <211> 321 <212> PRT <213> Homo sapiens <400> 190 Met Leu Thr Leu Asn Lys Thr Asp Leu Ile Pro Ala Ser Phe Ile Leu 1 5 10 15 Asn Gly Val Pro Gly Leu Glu Asp Thr Gln Leu Trp Ile Ser Phe Pro 20 25 30 Phe Cys Ser Met Tyr Val Val Ala Met Val Gly Asn Cys Gly Leu Leu 35 40 45 Tyr Leu Ile His Tyr Glu Asp Ala Leu His Lys Pro Met Tyr Tyr Phe 50 55 60 Leu Ala Met Leu Ser Phe Thr Asp Leu Val Met Cys Ser Ser Thr Ile 65 70 75 80 Pro Lys Ala Leu Cys Ile Phe Trp Phe His Leu Lys Asp Ile Gly Phe 85 90 95 Asp Glu Cys Leu Val Gln Met Phe Phe Ile His Thr Phe Thr Gly Met 100 105 110 Glu Ser Gly Val Leu Met Leu Met Ala Leu Asp Arg Tyr Val Ala Ile 115 120 125 Cys Tyr Pro Leu Arg Tyr Ser Thr Ile Leu Thr Asn Pro Val Ile Ala 130 135 140 Lys Val Gly Thr Ala Thr Phe Leu Arg Gly Val Leu Leu Ile Ile Pro 145 150 155 160 Phe Thr Phe Leu Thr Lys Arg Leu Pro Tyr Cys Arg Gly Asn Ile Leu 165 170 175 Pro His Thr Tyr Cys Asp His Met Ser Val Ala Lys Leu Ser Cys Gly 180 185 190 Asn Val Lys Val Asn Ala Ile Tyr Gly Leu Met Val Ala Leu Leu Ile 195 200 205 Gly Gly Phe Asp Ile Leu Cys Ile Thr Ile Ser Tyr Thr Met Ile Leu 210 215 220 Arg Ala Val Val Ser Leu Ser Ser Ala Asp Ala Arg Gln Lys Ala Phe 225 230 235 240 Asn Thr Cys Thr Ala His Ile Cys Ala Ile Val Phe Ser Tyr Thr Pro 245 250 255 Ala Phe Phe Ser Phe Phe Ser His Arg Phe Gly Glu His Ile Ile Pro 260 265 270 Pro Ser Cys His Ile Ile Val Ala Asn Ile Tyr Leu Leu Leu Pro Pro 275 280 285 Thr Met Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Gln Ile Arg Asp 290 295 300 Cys Val Ile Arg Ile Leu Ser Gly Ser Lys Asp Thr Lys Ser Tyr Ser 305 310 315 320 Met <210> 191 <211> 633 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(633) <400> 191 atg act gct tgc aat gcc tca cag ggc cac cct tct ttc ttc att ctc 48 Met Thr Ala Cys Asn Ala Ser Gln Gly His Pro Ser Phe Phe Ile Leu 1 5 10 15 caa gga att cct ggc atg gag gac aaa cac aga tgg ata tct atc ccc 96 Gln Gly Ile Pro Gly Met Glu Asp Lys His Arg Trp Ile Ser Ile Pro 20 25 30 ttc tcc tcc atg tat ttc att atg gtg ctt ggg aac tgc acc atc ctc 144 Phe Ser Ser Met Tyr Phe Ile Met Val Leu Gly Asn Cys Thr Ile Leu 35 40 45 ctc acc atc tcc aca gag cgc tcc ctg cac aaa ccc atg ttc ctg ctc 192 Leu Thr Ile Ser Thr Glu Arg Ser Leu His Lys Pro Met Phe Leu Leu 50 55 60 ctc tgt ctg ttg gcc ctc aca gac ctg ggc atg tct aca acc acc att 240 Leu Cys Leu Leu Ala Leu Thr Asp Leu Gly Met Ser Thr Thr Thr Ile 65 70 75 80 ccc aag gtg ctg tgc att ttc tgg ttt ggc cag agt gag atc agc tat 288 Pro Lys Val Leu Cys Ile Phe Trp Phe Gly Gln Ser Glu Ile Ser Tyr 85 90 95 gaa gga tgc ctg gtt cag ctg ttc ttc atc cac tcc atc tct gcc atg 336 Glu Gly Cys Leu Val Gln Leu Phe Phe Ile His Ser Ile Ser Ala Met 100 105 110 cag tca gct gtc ctg atg acc atg gcc ttt gac cac tat gtg gcc atc 384 Gln Ser Ala Val Leu Met Thr Met Ala Phe Asp His Tyr Val Ala Ile 115 120 125 tgc aag ccc ttg cgc tat gcc acc atc ctt tcc aat agt tgc act gga 432 Cys Lys Pro Leu Arg Tyr Ala Thr Ile Leu Ser Asn Ser Cys Thr Gly 130 135 140 ctc att ggc tta gtg agt ttg gtg aga gct atc ctc ttt att ctc ccc 480 Leu Ile Gly Leu Val Ser Leu Val Arg Ala Ile Leu Phe Ile Leu Pro 145 150 155 160 atg ccc atc ctc ctt cag caa atg ccc tat cat gcc aat cgt gtc atc 528 Met Pro Ile Leu Leu Gln Gln Met Pro Tyr His Ala Asn Arg Val Ile 165 170 175 ccc acc acc tcc tgt gag cac atg gct gtg gtg aag atg gtt tgt gta 576 Pro Thr Thr Ser Cys Glu His Met Ala Val Val Lys Met Val Cys Val 180 185 190 gat act aca gtc aac agg ata tat ggc ctg gtg gtg gcc ttg ttg gtt 624 Asp Thr Thr Val Asn Arg Ile Tyr Gly Leu Val Val Ala Leu Leu Val 195 200 205 gct ggc tag 633 Ala Gly 210 <210> 192 <211> 210 <212> PRT <213> Homo sapiens <400> 192 Met Thr Ala Cys Asn Ala Ser Gln Gly His Pro Ser Phe Phe Ile Leu 1 5 10 15 Gln Gly Ile Pro Gly Met Glu Asp Lys His Arg Trp Ile Ser Ile Pro 20 25 30 Phe Ser Ser Met Tyr Phe Ile Met Val Leu Gly Asn Cys Thr Ile Leu 35 40 45 Leu Thr Ile Ser Thr Glu Arg Ser Leu His Lys Pro Met Phe Leu Leu 50 55 60 Leu Cys Leu Leu Ala Leu Thr Asp Leu Gly Met Ser Thr Thr Thr Ile 65 70 75 80 Pro Lys Val Leu Cys Ile Phe Trp Phe Gly Gln Ser Glu Ile Ser Tyr 85 90 95 Glu Gly Cys Leu Val Gln Leu Phe Phe Ile His Ser Ile Ser Ala Met 100 105 110 Gln Ser Ala Val Leu Met Thr Met Ala Phe Asp His Tyr Val Ala Ile 115 120 125 Cys Lys Pro Leu Arg Tyr Ala Thr Ile Leu Ser Asn Ser Cys Thr Gly 130 135 140 Leu Ile Gly Leu Val Ser Leu Val Arg Ala Ile Leu Phe Ile Leu Pro 145 150 155 160 Met Pro Ile Leu Leu Gln Gln Met Pro Tyr His Ala Asn Arg Val Ile 165 170 175 Pro Thr Thr Ser Cys Glu His Met Ala Val Val Lys Met Val Cys Val 180 185 190 Asp Thr Thr Val Asn Arg Ile Tyr Gly Leu Val Val Ala Leu Leu Val 195 200 205 Ala Gly 210 <210> 193 <211> 1107 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1107) <400> 193 atg cct cac tgc ctt tta tgc aac aac aaa act cac tgg gcc cct gtt 48 Met Pro His Cys Leu Leu Cys Asn Asn Lys Thr His Trp Ala Pro Val 1 5 10 15 agg agc act atg tgc ttt gaa aag gaa gtg gaa tat ctc aac tgg aat 96 Arg Ser Thr Met Cys Phe Glu Lys Glu Val Glu Tyr Leu Asn Trp Asn 20 25 30 gac tcc ttg gcc atc cta ctc ctg att ctc tcc cta ctg gga atc ata 144 Asp Ser Leu Ala Ile Leu Leu Leu Ile Leu Ser Leu Leu Gly Ile Ile 35 40 45 ttt gtt ctg gtt gtt ggc ata ata ttt aca aga aac ctg aac aca cct 192 Phe Val Leu Val Val Gly Ile Ile Phe Thr Arg Asn Leu Asn Thr Pro 50 55 60 gtt gtg aaa tca tcc ggg gga tta aga gtc tgc tat gtg atc ctt ctc 240 Val Val Lys Ser Ser Gly Gly Leu Arg Val Cys Tyr Val Ile Leu Leu 65 70 75 80 tgt cat ttc ctc aat ttt gcc agc acg agc ttt ttc att gga gaa cca 288 Cys His Phe Leu Asn Phe Ala Ser Thr Ser Phe Phe Ile Gly Glu Pro 85 90 95 caa gac ttc aca tgt aaa acc agg cag aca atg ttt gga gtg agc ttt 336 Gln Asp Phe Thr Cys Lys Thr Arg Gln Thr Met Phe Gly Val Ser Phe 100 105 110 act ctt tgc atc tcc tgc att ttg acg aag tct ctg aaa att ttg cta 384 Thr Leu Cys Ile Ser Cys Ile Leu Thr Lys Ser Leu Lys Ile Leu Leu 115 120 125 gcc ttc agc ttt gat ccc aaa tta cag aaa ttt ctg aag tgc ctc tat 432 Ala Phe Ser Phe Asp Pro Lys Leu Gln Lys Phe Leu Lys Cys Leu Tyr 130 135 140 aga ccg atc ctt att atc ttc act tgc acg ggc atc cag gtt gtc att 480 Arg Pro Ile Leu Ile Ile Phe Thr Cys Thr Gly Ile Gln Val Val Ile 145 150 155 160 tgc aca ctc tgg cta atc ttt gca gca cct act gta gag gtg aat gtc 528 Cys Thr Leu Trp Leu Ile Phe Ala Ala Pro Thr Val Glu Val Asn Val 165 170 175 tcc ttg ccc aga gtc atc atc ctg gag tgt gag gag gga tcc ata ctt 576 Ser Leu Pro Arg Val Ile Ile Leu Glu Cys Glu Glu Gly Ser Ile Leu 180 185 190 gca ttt ggc acc atg ctg ggc tac att gcc atc ctg gcc ttc att tgc 624 Ala Phe Gly Thr Met Leu Gly Tyr Ile Ala Ile Leu Ala Phe Ile Cys 195 200 205 ttc ata ttt gct ttc aaa ggc aaa tat gag aat tac aat gaa gcc aaa 672 Phe Ile Phe Ala Phe Lys Gly Lys Tyr Glu Asn Tyr Asn Glu Ala Lys 210 215 220 ttc att aca ttt ggc atg ctc att tac ttc ata gct tgg atc aca ttc 720 Phe Ile Thr Phe Gly Met Leu Ile Tyr Phe Ile Ala Trp Ile Thr Phe 225 230 235 240 atc cct atc tat gct acc aca ttt ggc aaa tat gta cca gct gtg gag 768 Ile Pro Ile Tyr Ala Thr Thr Phe Gly Lys Tyr Val Pro Ala Val Glu 245 250 255 att att gtc ata tta ata tct aac tat gga atc ctg tat tgc aca ttc 816 Ile Ile Val Ile Leu Ile Ser Asn Tyr Gly Ile Leu Tyr Cys Thr Phe 260 265 270 atc ccc aaa tgc tat gtt att att tgt aag caa gag att aac aca aag 864 Ile Pro Lys Cys Tyr Val Ile Ile Cys Lys Gln Glu Ile Asn Thr Lys 275 280 285 tct gcc ttt ctc aag atg atc tac agt tat tct tcc cat agt gtg agc 912 Ser Ala Phe Leu Lys Met Ile Tyr Ser Tyr Ser Ser His Ser Val Ser 290 295 300 agc att gcc ctg agt cct gct tca ctg gac tcc atg agc ggc aat gtc 960 Ser Ile Ala Leu Ser Pro Ala Ser Leu Asp Ser Met Ser Gly Asn Val 305 310 315 320 aca atg acc aat ccc agc tct agt ggc aag tct gca acc tgg cag aaa 1008 Thr Met Thr Asn Pro Ser Ser Ser Gly Lys Ser Ala Thr Trp Gln Lys 325 330 335 agc aaa gat ctt cag gca caa gca ttt gca cac ata tgc agg gaa aat 1056 Ser Lys Asp Leu Gln Ala Gln Ala Phe Ala His Ile Cys Arg Glu Asn 340 345 350 gcc aca agt gta tct aaa act ttg cct cga aaa aga atg tca agt ata 1104 Ala Thr Ser Val Ser Lys Thr Leu Pro Arg Lys Arg Met Ser Ser Ile 355 360 365 tga 1107 <210> 194 <211> 368 <212> PRT <213> Homo sapiens <400> 194 Met Pro His Cys Leu Leu Cys Asn Asn Lys Thr His Trp Ala Pro Val 1 5 10 15 Arg Ser Thr Met Cys Phe Glu Lys Glu Val Glu Tyr Leu Asn Trp Asn 20 25 30 Asp Ser Leu Ala Ile Leu Leu Leu Ile Leu Ser Leu Leu Gly Ile Ile 35 40 45 Phe Val Leu Val Val Gly Ile Ile Phe Thr Arg Asn Leu Asn Thr Pro 50 55 60 Val Val Lys Ser Ser Gly Gly Leu Arg Val Cys Tyr Val Ile Leu Leu 65 70 75 80 Cys His Phe Leu Asn Phe Ala Ser Thr Ser Phe Phe Ile Gly Glu Pro 85 90 95 Gln Asp Phe Thr Cys Lys Thr Arg Gln Thr Met Phe Gly Val Ser Phe 100 105 110 Thr Leu Cys Ile Ser Cys Ile Leu Thr Lys Ser Leu Lys Ile Leu Leu 115 120 125 Ala Phe Ser Phe Asp Pro Lys Leu Gln Lys Phe Leu Lys Cys Leu Tyr 130 135 140 Arg Pro Ile Leu Ile Ile Phe Thr Cys Thr Gly Ile Gln Val Val Ile 145 150 155 160 Cys Thr Leu Trp Leu Ile Phe Ala Ala Pro Thr Val Glu Val Asn Val 165 170 175 Ser Leu Pro Arg Val Ile Ile Leu Glu Cys Glu Glu Gly Ser Ile Leu 180 185 190 Ala Phe Gly Thr Met Leu Gly Tyr Ile Ala Ile Leu Ala Phe Ile Cys 195 200 205 Phe Ile Phe Ala Phe Lys Gly Lys Tyr Glu Asn Tyr Asn Glu Ala Lys 210 215 220 Phe Ile Thr Phe Gly Met Leu Ile Tyr Phe Ile Ala Trp Ile Thr Phe 225 230 235 240 Ile Pro Ile Tyr Ala Thr Thr Phe Gly Lys Tyr Val Pro Ala Val Glu 245 250 255 Ile Ile Val Ile Leu Ile Ser Asn Tyr Gly Ile Leu Tyr Cys Thr Phe 260 265 270 Ile Pro Lys Cys Tyr Val Ile Ile Cys Lys Gln Glu Ile Asn Thr Lys 275 280 285 Ser Ala Phe Leu Lys Met Ile Tyr Ser Tyr Ser Ser His Ser Val Ser 290 295 300 Ser Ile Ala Leu Ser Pro Ala Ser Leu Asp Ser Met Ser Gly Asn Val 305 310 315 320 Thr Met Thr Asn Pro Ser Ser Ser Gly Lys Ser Ala Thr Trp Gln Lys 325 330 335 Ser Lys Asp Leu Gln Ala Gln Ala Phe Ala His Ile Cys Arg Glu Asn 340 345 350 Ala Thr Ser Val Ser Lys Thr Leu Pro Arg Lys Arg Met Ser Ser Ile 355 360 365 <210> 195 <211> 879 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(879) <400> 195 atg gtg gga aac ctc ctc att tgg gtg act act att ggc agc ccc tcc 48 Met Val Gly Asn Leu Leu Ile Trp Val Thr Thr Ile Gly Ser Pro Ser 1 5 10 15 ttg ggc tcc cta atg tac ttc ttc ctt gcc tac ttg tca ctt atg gat 96 Leu Gly Ser Leu Met Tyr Phe Phe Leu Ala Tyr Leu Ser Leu Met Asp 20 25 30 gcc ata tat tcc act gcc atg tca ccc aaa ttg atg ata gac tta ctc 144 Ala Ile Tyr Ser Thr Ala Met Ser Pro Lys Leu Met Ile Asp Leu Leu 35 40 45 tgt gat aaa atc gct att tcc ttg tca gct tgc atg ggt cag ctc ttc 192 Cys Asp Lys Ile Ala Ile Ser Leu Ser Ala Cys Met Gly Gln Leu Phe 50 55 60 ata gaa cac tta ctt ggt ggt gca gag gtc ttc ctt ttg gtg gtg atg 240 Ile Glu His Leu Leu Gly Gly Ala Glu Val Phe Leu Leu Val Val Met 65 70 75 80 gcc tat gat cgc tat gtg gct atc tct aag ccg ctg cac tat ttg aac 288 Ala Tyr Asp Arg Tyr Val Ala Ile Ser Lys Pro Leu His Tyr Leu Asn 85 90 95 atc atg aat cga ctg gtt tgc atc ctt ctg ttg gtg gtg gcc atg att 336 Ile Met Asn Arg Leu Val Cys Ile Leu Leu Leu Val Val Ala Met Ile 100 105 110 gga ggt ttt gtg cac tct gtg gtt caa att gtc ttt ctg tac agt cta 384 Gly Gly Phe Val His Ser Val Val Gln Ile Val Phe Leu Tyr Ser Leu 115 120 125 cca atc tgt ggc ccc aat gtt att gac cac tct gtc tgt gac atg tac 432 Pro Ile Cys Gly Pro Asn Val Ile Asp His Ser Val Cys Asp Met Tyr 130 135 140 cca ttg ttg gaa ctg ttg tgc ctt gac acc tac ttt ata gga ctc act 480 Pro Leu Leu Glu Leu Leu Cys Leu Asp Thr Tyr Phe Ile Gly Leu Thr 145 150 155 160 gtg gtt gcc aat ggt gga ata att tgt atg gtc atc ttt acc ttt ctg 528 Val Val Ala Asn Gly Gly Ile Ile Cys Met Val Ile Phe Thr Phe Leu 165 170 175 cta atc tcc tgt gga gtc atc cta aac ttc ctt aaa act tac agt cag 576 Leu Ile Ser Cys Gly Val Ile Leu Asn Phe Leu Lys Thr Tyr Ser Gln 180 185 190 gaa gag agg cat aaa gcc ctg cct acc tgc atc tcc cac atc att gtg 624 Glu Glu Arg His Lys Ala Leu Pro Thr Cys Ile Ser His Ile Ile Val 195 200 205 gtt gcc ctc gtt ttt gtt ccc tgt att ttt atg tat gtt aga ccc gtt 672 Val Ala Leu Val Phe Val Pro Cys Ile Phe Met Tyr Val Arg Pro Val 210 215 220 tcc aac ttt ccc ttt gat aaa tta atg act gtg ttt tat tca att atc 720 Ser Asn Phe Pro Phe Asp Lys Leu Met Thr Val Phe Tyr Ser Ile Ile 225 230 235 240 aca ctc atg ttg aat cct tta ata tac tcg ttg aga caa tca gag atg 768 Thr Leu Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Gln Ser Glu Met 245 250 255 aaa aat gct atg aaa aat ctc tgg tgt gaa aag tta agt ata gtt aga 816 Lys Asn Ala Met Lys Asn Leu Trp Cys Glu Lys Leu Ser Ile Val Arg 260 265 270 aaa aga gta tct ccc aca ctg aac ata ttt att cct agt tct aag gca 864 Lys Arg Val Ser Pro Thr Leu Asn Ile Phe Ile Pro Ser Ser Lys Ala 275 280 285 aca aat agg cgg taa 879 Thr Asn Arg Arg 290 <210> 196 <211> 292 <212> PRT <213> Homo sapiens <400> 196 Met Val Gly Asn Leu Leu Ile Trp Val Thr Thr Ile Gly Ser Pro Ser 1 5 10 15 Leu Gly Ser Leu Met Tyr Phe Phe Leu Ala Tyr Leu Ser Leu Met Asp 20 25 30 Ala Ile Tyr Ser Thr Ala Met Ser Pro Lys Leu Met Ile Asp Leu Leu 35 40 45 Cys Asp Lys Ile Ala Ile Ser Leu Ser Ala Cys Met Gly Gln Leu Phe 50 55 60 Ile Glu His Leu Leu Gly Gly Ala Glu Val Phe Leu Leu Val Val Met 65 70 75 80 Ala Tyr Asp Arg Tyr Val Ala Ile Ser Lys Pro Leu His Tyr Leu Asn 85 90 95 Ile Met Asn Arg Leu Val Cys Ile Leu Leu Leu Val Val Ala Met Ile 100 105 110 Gly Gly Phe Val His Ser Val Val Gln Ile Val Phe Leu Tyr Ser Leu 115 120 125 Pro Ile Cys Gly Pro Asn Val Ile Asp His Ser Val Cys Asp Met Tyr 130 135 140 Pro Leu Leu Glu Leu Leu Cys Leu Asp Thr Tyr Phe Ile Gly Leu Thr 145 150 155 160 Val Val Ala Asn Gly Gly Ile Ile Cys Met Val Ile Phe Thr Phe Leu 165 170 175 Leu Ile Ser Cys Gly Val Ile Leu Asn Phe Leu Lys Thr Tyr Ser Gln 180 185 190 Glu Glu Arg His Lys Ala Leu Pro Thr Cys Ile Ser His Ile Ile Val 195 200 205 Val Ala Leu Val Phe Val Pro Cys Ile Phe Met Tyr Val Arg Pro Val 210 215 220 Ser Asn Phe Pro Phe Asp Lys Leu Met Thr Val Phe Tyr Ser Ile Ile 225 230 235 240 Thr Leu Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Gln Ser Glu Met 245 250 255 Lys Asn Ala Met Lys Asn Leu Trp Cys Glu Lys Leu Ser Ile Val Arg 260 265 270 Lys Arg Val Ser Pro Thr Leu Asn Ile Phe Ile Pro Ser Ser Lys Ala 275 280 285 Thr Asn Arg Arg 290 <210> 197 <211> 957 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(957) <400> 197 atg tca gat tcc aac ctc agt gat aac cat ctt cca gac acc ttc ttc 48 Met Ser Asp Ser Asn Leu Ser Asp Asn His Leu Pro Asp Thr Phe Phe 1 5 10 15 tta aca ggg atc cca ggg ctg gag gct gcc cac ttc tgg att gcc atc 96 Leu Thr Gly Ile Pro Gly Leu Glu Ala Ala His Phe Trp Ile Ala Ile 20 25 30 cct ttc tgt gcc atg tat ctt gta gca ctg gtt gga aat gct gcc ctc 144 Pro Phe Cys Ala Met Tyr Leu Val Ala Leu Val Gly Asn Ala Ala Leu 35 40 45 atc ctg gtc att gcc atg gac aat gct ctt cat gca cct atg tac ctc 192 Ile Leu Val Ile Ala Met Asp Asn Ala Leu His Ala Pro Met Tyr Leu 50 55 60 ttc ctc tgc ctt ctc tca ctc aca gac ctg gct ctc agt tct acc act 240 Phe Leu Cys Leu Leu Ser Leu Thr Asp Leu Ala Leu Ser Ser Thr Thr 65 70 75 80 gtg ccc aag atg ctg gcc att ttg tgg ctc cat gct ggt gag att tcc 288 Val Pro Lys Met Leu Ala Ile Leu Trp Leu His Ala Gly Glu Ile Ser 85 90 95 ttt ggt gga tgc ctg gcc cag atg ttt tgt gtc cat tct atc tat gct 336 Phe Gly Gly Cys Leu Ala Gln Met Phe Cys Val His Ser Ile Tyr Ala 100 105 110 ctg gag tcc tcg att cta ctt gcc atg gcc ttt gat agg tat gtg gct 384 Leu Glu Ser Ser Ile Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala 115 120 125 atc tgt aac cca tta agg tat aca acc att ctc aac cat gct gtc ata 432 Ile Cys Asn Pro Leu Arg Tyr Thr Thr Ile Leu Asn His Ala Val Ile 130 135 140 ggc aga att ggc ttt gtt ggg cta ttc cgt agt gtg gct att gtc tcc 480 Gly Arg Ile Gly Phe Val Gly Leu Phe Arg Ser Val Ala Ile Val Ser 145 150 155 160 ccc ttc atc ttc ttg ctg agg cga ctc ccc tac tgt ggt cac cgt gtc 528 Pro Phe Ile Phe Leu Leu Arg Arg Leu Pro Tyr Cys Gly His Arg Val 165 170 175 atg aca cac aca tac tgt gag cat atg ggc atc gcc cga ctg gcc tgt 576 Met Thr His Thr Tyr Cys Glu His Met Gly Ile Ala Arg Leu Ala Cys 180 185 190 gcc aac atc act gtc aat att gtc tat ggg cta act gtg gct ctg ctg 624 Ala Asn Ile Thr Val Asn Ile Val Tyr Gly Leu Thr Val Ala Leu Leu 195 200 205 gcc atg gga ctg gat tcc att ctc att gcc att tcc tat ggc ttt atc 672 Ala Met Gly Leu Asp Ser Ile Leu Ile Ala Ile Ser Tyr Gly Phe Ile 210 215 220 ctc cat gca gtc ttt cac ctt cca tct cat gat gcc cag cac aaa gct 720 Leu His Ala Val Phe His Leu Pro Ser His Asp Ala Gln His Lys Ala 225 230 235 240 ctg agt acc tgt ggc tcc cac att ggc atc atc ctg gtt ttc tac atc 768 Leu Ser Thr Cys Gly Ser His Ile Gly Ile Ile Leu Val Phe Tyr Ile 245 250 255 cct gcc ttc ttc tcc ttc ctc acc cac cgc ttt ggt cac cac gaa gtc 816 Pro Ala Phe Phe Ser Phe Leu Thr His Arg Phe Gly His His Glu Val 260 265 270 ccc aag cat gtg cac atc ttt ctg gct aat ctc tat gtg ctg gtg cct 864 Pro Lys His Val His Ile Phe Leu Ala Asn Leu Tyr Val Leu Val Pro 275 280 285 cct gta ctc aat cct att ctc tat gga gct aga acc aag gag att cgg 912 Pro Val Leu Asn Pro Ile Leu Tyr Gly Ala Arg Thr Lys Glu Ile Arg 290 295 300 agt cga ctt cta aaa ctg ctt cac ctg ggg aag act tca ata tga 957 Ser Arg Leu Leu Lys Leu Leu His Leu Gly Lys Thr Ser Ile 305 310 315 <210> 198 <211> 318 <212> PRT <213> Homo sapiens <400> 198 Met Ser Asp Ser Asn Leu Ser Asp Asn His Leu Pro Asp Thr Phe Phe 1 5 10 15 Leu Thr Gly Ile Pro Gly Leu Glu Ala Ala His Phe Trp Ile Ala Ile 20 25 30 Pro Phe Cys Ala Met Tyr Leu Val Ala Leu Val Gly Asn Ala Ala Leu 35 40 45 Ile Leu Val Ile Ala Met Asp Asn Ala Leu His Ala Pro Met Tyr Leu 50 55 60 Phe Leu Cys Leu Leu Ser Leu Thr Asp Leu Ala Leu Ser Ser Thr Thr 65 70 75 80 Val Pro Lys Met Leu Ala Ile Leu Trp Leu His Ala Gly Glu Ile Ser 85 90 95 Phe Gly Gly Cys Leu Ala Gln Met Phe Cys Val His Ser Ile Tyr Ala 100 105 110 Leu Glu Ser Ser Ile Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala 115 120 125 Il e Cys Asn Pro Leu Arg Tyr Thr Thr Ile Leu Asn His Ala Val Ile 130 135 140 Gly Arg Ile Gly Phe Val Gly Leu Phe Arg Ser Val Ala Ile Val Ser 145 150 155 160 Pro Phe Ile Phe Leu Leu Arg Arg Leu Pro Tyr Cys Gly His Arg Val 165 170 175 Met Thr His Thr Tyr Cys Glu His Met Gly Ile Ala Arg Leu Ala Cys 180 185 190 Ala Asn Ile Thr Val Asn Ile Val Tyr Gly Leu Thr Val Ala Leu Leu 195 200 205 Ala Met Gly Leu Asp Ser Ile Leu Ile Ala Ile Ser Tyr Gly Phe Ile 210 215 220 Leu His Ala Val Phe His Leu Pro Ser His Asp Ala Gln His Lys Ala 225 230 235 240 Leu Ser Thr Cys Gly Ser His Ile Gly Ile Ile Leu Val Phe Tyr Ile 245 250 255 Pro Ala Phe Phe Ser Phe Leu Thr His Arg Phe Gly His His Glu Val 260 265 270 Pro Lys His Val His Ile Phe Leu Ala Asn Leu Tyr Val Leu Val Pro 275 280 285 Pro Val Leu Asn Pro Ile Leu Tyr Gly Ala Arg Thr Lys Glu Ile Arg 290 295 300 Ser Arg Leu Leu Lys Leu Leu His Leu Gly Lys Thr Ser Ile 305 310 315 <210> 199 <211> 729 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(729) <400> 199 atg gct ccg acc aac ctc aca tct gcc ccc gtg ttc ctc ctc ctc ggc 48 Met Ala Pro Thr Asn Leu Thr Ser Ala Pro Val Phe Leu Leu Leu Gly 1 5 10 15 ctg gtg gac gga aca gac gcc cac ccg ctg ctg ttc ctg ctc tgc ctt 96 Leu Val Asp Gly Thr Asp Ala His Pro Leu Leu Phe Leu Leu Cys Leu 20 25 30 ggc atc tat ctg ctc aac gcc ctg agc aac ctg agc atg gtg gcg ctg 144 Gly Ile Tyr Leu Leu Asn Ala Leu Ser Asn Leu Ser Met Val Ala Leu 35 40 45 gtg aga tcc gac ggg gcc ctc cgc tcc ccc atg tat tac ttc ttg ggt 192 Val Arg Ser Asp Gly Ala Leu Arg Ser Pro Met Tyr Tyr Phe Leu Gly 50 55 60 cac ctg agc ctc gtg gac gtc tgc ttt acc acc gtc acg gtc ccc agg 240 His Leu Ser Leu Val Asp Val Cys Phe Thr Thr Val Thr Val Pro Arg 65 70 75 80 ctg ctg gcc ggc ctg ctc cac ccg ggc cag gcc ata tcc ttc cag gcg 288 Leu Leu Ala Gly Leu Leu His Pro Gly Gln Ala Ile Ser Phe Gln Ala 85 90 95 tgc ttt gcc gag atg tac ttc ttc gtg gct ctg ggc atc acc gag agc 336 Cys Phe Ala Glu Met Tyr Phe Phe Val Ala Leu Gly Ile Thr Glu Ser 100 105 110 tac ctc ctg gcg gcc atg tcc tac gac cgc gcg acg gcg gcg tgc cgg 384 Tyr Leu Leu Ala Ala Met Ser Tyr Asp Arg Ala Thr Ala Ala Cys Arg 115 120 125 ccc ctg cgc tac ggc gcg ctg gtg acg cca tgg gcg tgc gcc tcg ctg 432 Pro Leu Arg Tyr Gly Ala Leu Val Thr Pro Trp Ala Cys Ala Ser Leu 130 135 140 gtg cgt gcg tcg tgg gcc gtg acg cac ctg cac tcg ctg ctg cac acg 480 Val Arg Ala Ser Trp Ala Val Thr His Leu His Ser Leu Leu His Thr 145 150 155 160 ctg ctc ctc tcc gcg ctc tcc tac ccc tac ccc acc ccc gtg cgc ccc 528 Leu Leu Leu Ser Ala Leu Ser Tyr Pro Tyr Pro Thr Pro Val Arg Pro 165 170 175 ttc ttt tgc gac atg acg gtg atg ctg agc ttg gcg acc tcg gac acg 576 Phe Phe Cys Asp Met Thr Val Met Leu Ser Leu Ala Thr Ser Asp Thr 180 185 190 tcc gcc gcg gag acg gcc atc ttc tcc gag ggc ctg gcc gtg gtg ttg 624 Ser Ala Ala Glu Thr Ala Ile Phe Ser Glu Gly Leu Ala Val Val Leu 195 200 205 gcc ccg ctg ctc ctc gtg ttc ctt ttc cta cgc gcg cat cct ggt cgc 672 Ala Pro Leu Leu Leu Val Phe Leu Phe Leu Arg Ala His Pro Gly Arg 210 215 220 ggt gct cgg ctt gcc gcg gcc ggc gcc gcg cct tct cct act gcg ggg 720 Gly Ala Arg Leu Ala Ala Ala Gly Ala Ala Pro Ser Pro Thr Ala Gly 225 230 235 240 ccc acc tag 729 Pro Thr <210> 200 <211> 242 <212> PRT <213> Homo sapiens <400> 200 Met Ala Pro Thr Asn Leu Thr Ser Ala Pro Val Phe Leu Leu Leu Gly 1 5 10 15 Leu Val Asp Gly Thr Asp Ala His Pro Leu Leu Phe Leu Leu Cys Leu 20 25 30 Gly Ile Tyr Leu Leu Asn Ala Leu Ser Asn Leu Ser Met Val Ala Leu 35 40 45 Val Arg Ser Asp Gly Ala Leu Arg Ser Pro Met Tyr Tyr Phe Leu Gly 50 55 60 His Leu Ser Leu Val Asp Val Cys Phe Thr Thr Val Thr Val Pro Arg 65 70 75 80 Leu Leu Ala Gly Leu Leu His Pro Gly Gln Ala Ile Ser Phe Gln Ala 85 90 95 Cys Phe Ala Glu Met Tyr Phe Phe Val Ala Leu Gly Ile Thr Glu Ser 100 105 110 Tyr Leu Leu Ala Ala Met Ser Tyr Asp Arg Ala Thr Ala Ala Cys Arg 115 120 125 Pro Leu Arg Tyr Gly Ala Leu Val Thr Pro Trp Ala Cys Ala Ser Leu 130 135 140 Val Arg Ala Ser Trp Ala Val Thr His Leu His Ser Leu Leu His Thr 145 150 155 160 Leu Leu Leu Ser Ala Leu Ser Tyr Pro Tyr Pro Thr Pro Val Arg Pro 165 170 175 Phe Phe Cys Asp Met Thr Val Met Leu Ser Leu Ala Thr Ser Asp Thr 180 185 190 Ser Ala Ala Glu Thr Ala Ile Phe Ser Glu Gly Leu Ala Val Val Leu 195 200 205 Ala Pro Leu Leu Leu Val Phe Leu Phe Leu Arg Ala His Pro Gly Arg 210 215 220 Gly Ala Arg Leu Ala Ala Ala Gly Ala Ala Pro Ser Pro Thr Ala Gly 225 230 235 240 Pro Thr <210> 201 <211> 942 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(942) <400> 201 atg gaa act gca aat tac acc aag gtg aca gaa ttt gtt ctc act ggc 48 Met Glu Thr Ala Asn Tyr Thr Lys Val Thr Glu Phe Val Leu Thr Gly 1 5 10 15 cta tcc cag act cgg gag gtc caa cta gtc cta ttt gtt ata ttt cta 96 Leu Ser Gln Thr Arg Glu Val Gln Leu Val Leu Phe Val Ile Phe Leu 20 25 30 tcc ttc tat ttg ttc atc cta cca gga aat atc ctt atc att tgc acc 144 Ser Phe Tyr Leu Phe Ile Leu Pro Gly Asn Ile Leu Ile Ile Cys Thr 35 40 45 atc agg cta gac cct cat ctg act tct cct atg tat ttc ctg ttg gct 192 Ile Arg Leu Asp Pro His Leu Thr Ser Pro Met Tyr Phe Leu Leu Ala 50 55 60 aat ctg gcc ctc ctt gat att tgg tac tct tcc att aca gcc cct aaa 240 Asn Leu Ala Leu Leu Asp Ile Trp Tyr Ser Ser Ile Thr Ala Pro Lys 65 70 75 80 atg ctc ata gac ttc ttt gtg gag agg aag ata att tcc ttt ggt gga 288 Met Leu Ile Asp Phe Phe Val Glu Arg Lys Ile Ile Ser Phe Gly Gly 85 90 95 tgc att gca cag ctc ttc ttc tta cac ttt gtt ggg gct tcg gag atg 336 Cys Ile Ala Gln Leu Phe Phe Leu His Phe Val Gly Ala Ser Glu Met 100 105 110 ttc ttg ctc ata gtg atg gcc tat gac cgc tat gct gct atc tgc cga 384 Phe Leu Leu Ile Val Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys Arg 115 120 125 ccc ctc cac tat gct acc atc atg aat cga cgt ctc tgc tgt atc ctg 432 Pro Leu His Tyr Ala Thr Ile Met Asn Arg Arg Leu Cys Cys Ile Leu 130 135 140 gtg gct ctc tcc tgg atg ggg ggc ttc att cat tct ata ata cag gtg 480 Val Ala Leu Ser Trp Met Gly Gly Phe Ile His Ser Ile Ile Gln Val 145 150 155 160 gct ctc att gtt cga ctt cct ttc tgt ggg ccc aat gag tta gac agt 528 Ala Leu Ile Val Arg Leu Pro Phe Cys Gly Pro Asn Glu Leu Asp Ser 165 170 175 tac ttc tgt gac atc aca cag gtt gtc cgg att gcc tgt gcc aac acc 576 Tyr Phe Cys Asp Ile Thr Gln Val Val Arg Ile Ala Cys Ala Asn Thr 180 185 190 ttc cca gag gag tta gtg atg atc tgt agt agt ggt ctg atc tct gtg 624 Phe Pro Glu Glu Leu Val Met Ile Cys Ser Ser Gly Leu Ile Ser Val 195 200 205 gtg tgt ttc att gct ctg tta atg tcc tat gcc ttc ctt ctg gcc ttg 672 Val Cys Phe Ile Ala Leu Leu Met Ser Tyr Ala Phe Leu Leu Ala Leu 210 215 220 ctc aag aaa cat tca ggc tca gat gag aat acc aac agg gcc atg tcc 720 Leu Lys Lys His Ser Gly Ser Asp Glu Asn Thr Asn Arg Ala Met Ser 225 230 235 240 acc tgc tat tcc cac att acc att gtg gtg cta atg ttt ggg cca tcc 768 Thr Cys Tyr Ser His Ile Thr Ile Val Val Leu Met Phe Gly Pro Ser 245 250 255 atc tac att tat gct cgc cca ttt gac tca ttt tcc cta gat aaa gtg 816 Ile Tyr Ile Tyr Ala Arg Pro Phe Asp Ser Phe Ser Leu Asp Lys Val 260 265 270 gtg tct gtg ttt cat act gta ata ttc cct tta ctt aat ccc att att 864 Val Ser Val Phe His Thr Val Ile Phe Pro Leu Leu Asn Pro Ile Ile 275 280 285 tac aca ttg aga aac aag gaa gta aag gca gcc atg agg aag gtg gtc 912 Tyr Thr Leu Arg Asn Lys Glu Val Lys Ala Ala Met Arg Lys Val Val 290 295 300 acc aaa tat att ttg tgt gaa gag aag tga 942 Thr Lys Tyr Ile Leu Cys Glu Glu Lys 305 310 <210> 202 <211> 313 <212> PRT <213> Homo sapiens <400> 202 Met Glu Thr Ala Asn Tyr Thr Lys Val Thr Glu Phe Val Leu Thr Gly 1 5 10 15 Leu Ser Gln Thr Arg Glu Val Gln Leu Val Leu Phe Val Ile Phe Leu 20 25 30 Ser Phe Tyr Leu Phe Ile Leu Pro Gly Asn Ile Leu Ile Ile Cys Thr 35 40 45 Ile Arg Leu Asp Pro His Leu Thr Ser Pro Met Tyr Phe Leu Leu Ala 50 55 60 Asn Leu Ala Leu Leu Asp Ile Trp Tyr Ser Ser Ile Thr Ala Pro Lys 65 70 75 80 Met Leu Ile Asp Phe Phe Val Glu Arg Lys Ile Ile Ser Phe Gly Gly 85 90 95 Cys Ile Ala Gln Leu Phe Phe Leu His Phe Val Gly Ala Ser Glu Met 100 105 110 Phe Leu Leu Ile Val Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys Arg 115 120 125 Pro Leu His Tyr Ala Thr Ile Met Asn Arg Arg Leu Cys Cys Ile Leu 130 135 140 Val Ala Leu Ser Trp Met Gly Gly Phe Ile His Ser Ile Ile Gln Val 145 150 155 160 Ala Leu Ile Val Arg Leu Pro Phe Cys Gly Pro Asn Glu Leu Asp Ser 165 170 175 Tyr Phe Cys Asp Ile Thr Gln Val Val Arg Ile Ala Cys Ala Asn Thr 180 185 190 Phe Pro Glu Glu Leu Val Met Ile Cys Ser Ser Gly Leu Ile Ser Val 195 200 205 Val Cys Phe Ile Ala Leu Leu Met Ser Tyr Ala Phe Leu Leu Ala Leu 210 215 220 Leu Lys Lys His Ser Gly Ser Asp Glu Asn Thr Asn Arg Ala Met Ser 225 230 235 240 Thr Cys Tyr Ser His Ile Thr Ile Val Val Leu Met Phe Gly Pro Ser 245 250 255 Ile Tyr Ile Tyr Ala Arg Pro Phe Asp Ser Phe Ser Leu Asp Lys Val 260 265 270 Val Ser Val Phe His Thr Val Ile Phe Pro Leu Leu Asn Pro Ile Ile 275 280 285 Tyr Thr Leu Arg Asn Lys Glu Val Lys Ala Ala Met Arg Lys Val Val 290 295 300 Thr Lys Tyr Ile Leu Cys Glu Glu Lys 305 310 <210> 203 <211> 966 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(966) <400> 203 atg tct ggg gac aac agc tcc agc ctg acc cca gga ttc ttt atc ttg 48 Met Ser Gly Asp Asn Ser Ser Ser Leu Thr Pro Gly Phe Phe Ile Leu 1 5 10 15 aat ggc gtt cct ggg ctg gaa gcc aca cac atc tgg atc tcc ctg cca 96 Asn Gly Val Pro Gly Leu Glu Ala Thr His Ile Trp Ile Ser Leu Pro 20 25 30 ttc tgc ttt atg tac atc att gct gtc gtg ggg aac tgt ggg ctc atc 144 Phe Cys Phe Met Tyr Ile Ile Ala Val Val Gly Asn Cys Gly Leu Ile 35 40 45 tgc ctc atc agc cat gag gag gcc ctg cac cgg ccc atg tac tac ttc 192 Cys Leu Ile Ser His Glu Glu Ala Leu His Arg Pro Met Tyr Tyr Phe 50 55 60 ctg gcc ctg ctc tcc ttc act gat gtc acc ttg tgc acc acc atg gta 240 Leu Ala Leu Leu Ser Phe Thr Asp Val Thr Leu Cys Thr Thr Met Val 65 70 75 80 cct aat atg ctg tgc ata ttc tgg ttc aac ctc aag gag att gac ttt 288 Pro Asn Met Leu Cys Ile Phe Trp Phe Asn Leu Lys Glu Ile Asp Phe 85 90 95 aac gcc tgc ctg gcc cag atg ttt ttt gtc cat atg ctg aca ggg atg 336 Asn Ala Cys Leu Ala Gln Met Phe Phe Val His Met Leu Thr Gly Met 100 105 110 gag tct ggg gtg ctc atg ctc atg gcc ctg gac cgc tat gtg gcc atc 384 Glu Ser Gly Val Leu Met Leu Met Ala Leu Asp Arg Tyr Val Ala Ile 115 120 125 tgc tac ccc tta cgc tat gcc acc atc ctt acc aac cct gtc atc gcc 432 Cys Tyr Pro Leu Arg Tyr Ala Thr Ile Leu Thr Asn Pro Val Ile Ala 130 135 140 aag gct ggt ctt gcc acc ttc ttg agg aat gtg atg ctc atc atc cca 480 Lys Ala Gly Leu Ala Thr Phe Leu Arg Asn Val Met Leu Ile Ile Pro 145 150 155 160 ttc act ctc ctc acc aag cgc ctg ccc tat tgc cgg ggg aac ttc atc 528 Phe Thr Leu Leu Thr Lys Arg Leu Pro Tyr Cys Arg Gly Asn Phe Ile 165 170 175 ccc cac acc tac tgt gac cat atg tct gtg gcc aag gta tcc tgt ggc 576 Pro His Thr Tyr Cys Asp His Met Ser Val Ala Lys Val Ser Cys Gly 180 185 190 aat ttc aag gtc aat gct att tat ggt ctg atg gtt gct ctc ctg att 624 Asn Phe Lys Val Asn Ala Ile Tyr Gly Leu Met Val Ala Leu Leu Ile 195 200 205 ggt gtg ttt gat atc tgc tgt atc tct gta tct tac act atg att ttg 672 Gly Val Phe Asp Ile Cys Cys Ile Ser Val Ser Tyr Thr Met Ile Leu 210 215 220 cag gct gtt atg agc ctg tca tca gca gat gct cgt cac aaa gcc ttc 720 Gln Ala Val Met Ser Leu Ser Ser Ala Asp Ala Arg His Lys Ala Phe 225 230 235 240 agc acc tgc aca tct cac atg tgt tcc att gtg atc acc tat gtt gct 768 Ser Thr Cys Thr Ser His Met Cys Ser Ile Val Ile Thr Tyr Val Ala 245 250 255 gct ttt ttc act ttt ttc act cat cgt ttt gta gga cac aat atc cca 816 Ala Phe Phe Thr Phe Phe Thr His Arg Phe Val Gly His Asn Ile Pro 260 265 270 aac cac ata cac atc atc gtg gcc aac ctt tat ctg cta ctg cct cct 864 Asn His Ile His Ile Ile Val Ala Asn Leu Tyr Leu Leu Leu Pro Pro 275 280 285 acc atg aac cca att gtt tat gga gtc aag acc aag cag att cag gaa 912 Thr Met Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Gln Ile Gln Glu 290 295 300 ggt gta att aaa ttt tta ctt gga gac aag gtt agt ttt acc tat gac 960 Gly Val Ile Lys Phe Leu Leu Gly Asp Lys Val Ser Phe Thr Tyr Asp 305 310 315 320 aaa tga 966 Lys <210> 204 <211> 321 <212> PRT <213> Homo sapiens <400> 204 Met Ser Gly Asp Asn Ser Ser Ser Leu Thr Pro Gly Phe Phe Ile Leu 1 5 10 15 Asn Gly Val Pro Gly Leu Glu Ala Thr His Ile Trp Ile Ser Leu Pro 20 25 30 Phe Cys Phe Met Tyr Ile Ile Ala Val Val Gly Asn Cys Gly Leu Ile 35 40 45 Cys Leu Ile Ser His Glu Glu Ala Leu His Arg Pro Met Tyr Tyr Phe 50 55 60 Leu Ala Leu Leu Ser Phe Thr Asp Val Thr Leu Cys Thr Thr Met Val 65 70 75 80 Pro Asn Met Leu Cys Ile Phe Trp Phe Asn Leu Lys Glu Ile Asp Phe 85 90 95 Asn Ala Cys Leu Ala Gln Met Phe Phe Val His Met Leu Thr Gly Met 100 105 110 Glu Ser Gly Val Leu Met Leu Met Ala Leu Asp Arg Tyr Val Ala Ile 115 120 125 Cys Tyr Pro Leu Arg Tyr Ala Thr Ile Leu Thr Asn Pro Val Ile Ala 130 135 140 Lys Ala Gly Leu Ala Thr Phe Leu Arg Asn Val Met Leu Ile Ile Pro 145 150 155 160 Phe Thr Leu Leu Thr Lys Arg Leu Pro Tyr Cys Arg Gly Asn Phe Ile 165 170 175 Pro His Thr Tyr Cys Asp His Met Ser Val Ala Lys Val Ser Cys Gly 180 185 190 Asn Phe Lys Val Asn Ala Ile Tyr Gly Leu Met Val Ala Leu Leu Ile 195 200 205 Gly Val Phe Asp Ile Cys Cys Ile Ser Val Ser Tyr Thr Met Ile Leu 210 215 220 Gln Ala Val Met Ser Leu Ser Ser Ala Asp Ala Arg His Lys Ala Phe 225 230 235 240 Ser Thr Cys Thr Ser His Met Cys Ser Ile Val Ile Thr Tyr Val Ala 245 250 255 Ala Phe Phe Thr Phe Phe Thr His Arg Phe Val Gly His Asn Ile Pro 260 265 270 Asn His Ile His Ile Ile Val Ala Asn Leu Tyr Leu Leu Leu Pro Pro 275 280 285 Thr Met Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Gln Ile Gln Glu 290 295 300 Gly Val Ile Lys Phe Leu Leu Gly Asp Lys Val Ser Phe Thr Tyr Asp 305 310 315 320 Lys <210> 205 <211> 963 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(963) <400> 205 atg tca ttt cta aat ggc acc agc cta act cca gct tca ttc atc cta 48 Met Ser Phe Leu Asn Gly Thr Ser Leu Thr Pro Ala Ser Phe Ile Leu 1 5 10 15 aat ggc atc cct ggt ttg gaa gat gtg cat ttg tgg atc tcc ttc cca 96 Asn Gly Ile Pro Gly Leu Glu Asp Val His Leu Trp Ile Ser Phe Pro 20 25 30 ctg tgt acc atg tac agc att gct att aca ggg aac ttc ggc ctt atg 144 Leu Cys Thr Met Tyr Ser Ile Ala Ile Thr Gly Asn Phe Gly Leu Met 35 40 45 tac ctc atc tac tgt gat gag gcc tta cac aga cct atg tat gtc ttc 192 Tyr Leu Ile Tyr Cys Asp Glu Ala Leu His Arg Pro Met Tyr Val Phe 50 55 60 ctt gcc ctt ctt tcc ttc aca gat gtg ctc atg tgc acc agc acc ctt 240 Leu Ala Leu Leu Ser Phe Thr Asp Val Leu Met Cys Thr Ser Thr Leu 65 70 75 80 ccc aac act ctc ttc ata ttg tgg ttt aat ctc aag gag att gat ttt 288 Pro Asn Thr Leu Phe Ile Leu Trp Phe Asn Leu Lys Glu Ile Asp Phe 85 90 95 a aa gcc tgc ctc gcc cag atg ttc ttt gtg cac acc ttc aca ggg atg 336 Lys Ala Cys Leu Ala Gln Met Phe Phe Val His Thr Phe Thr Gly Met 100 105 110 gag tct ggg gtg ctc atg ctc atg gcc ctg gac cac tgt gtg gcc atc 384 Glu Ser Gly Val Leu Met Leu Met Ala Leu Asp His Cys Val Ala Ile 115 120 125 tgc ttc cct ctg cgt tat gcc acc atc ctc act aat tca gtc att gct 432 Cys Phe Pro Leu Arg Tyr Ala Thr Ile Leu Thr Asn Ser Val Ile Ala 130 135 140 aaa gct ggg ttc ctc act ttt ctt agg ggt gtg atg ctt gtt atc cct 480 Lys Ala Gly Phe Leu Thr Phe Leu Arg Gly Val Met Leu Val Ile Pro 145 150 155 160 tcc act ttc ctc acc aag cgc ctt cca tac tgc aag ggc aac gtc ata 528 Ser Thr Phe Leu Thr Lys Arg Leu Pro Tyr Cys Lys Gly Asn Val Ile 165 170 175 ccc cac acc tac tgt gac cac atg tct gtg gcc aag ata tct tgt ggt 576 Pro His Thr Tyr Cys Asp His Met Ser Val Ala Lys Ile Ser Cys Gly 180 185 190 aat gtc agg gtt aac gcc atc tat ggt ttg ata gtt gcc ctg ctg att 624 Asn Val Arg Val Asn Ala Ile Tyr Gly Leu Ile Val Ala Leu Leu Ile 195 200 205 ggg ggc ttt gat atc ctg tgc att aca atc tcc tac act atg att ctt 672 Gly Gly Phe Asp Ile Leu Cys Ile Thr Ile Ser Tyr Thr Met Ile Leu 210 215 220 caa gca gtt gtg agt cta tca tca gca gat gct cga cag aag gcc ttc 720 Gln Ala Val Val Ser Leu Ser Ser Ala Asp Ala Arg Gln Lys Ala Phe 225 230 235 240 agc acc tgc act gcc cac ttc tgt gcc ata gtc ctc acc tat gtt cca 768 Ser Thr Cys Thr Ala His Phe Cys Ala Ile Val Leu Thr Tyr Val Pro 245 250 255 gcc ttc ttt acc ttc ttt aca cac cat ttt ggg gga cac acc att cct 816 Ala Phe Phe Thr Phe Phe Thr His His Phe Gly Gly His Thr Ile Pro 260 265 270 cta cac ata cat att att atg gct aat ctc tac cta cta atg cct ccc 864 Leu His Ile His Ile Ile Met Ala Asn Leu Tyr Leu Leu Met Pro Pro 275 280 285 aca atg aac cct att gtg tat ggg gtg aaa acc agg cag gta cga gaa 912 Thr Met Asn Pro Ile Val Tyr Gly Val Lys Thr Arg Gln Val Arg Glu 290 295 300 agt gtc att agg ttc ttt ctt aag gga aag gac aat tct cat aac ttt 960 Ser Val Ile Arg Phe Phe Leu Lys Gly Lys Asp Asn Ser His Asn Phe 305 310 315 320 taa 963 <210> 206 <211> 320 <212> PRT <213> Homo sapiens <400> 206 Met Ser Phe Leu Asn Gly Thr Ser Leu Thr Pro Ala Ser Phe Ile Leu 1 5 10 15 Asn Gly Ile Pro Gly Leu Glu Asp Val His Leu Trp Ile Ser Phe Pro 20 25 30 Leu Cys Thr Met Tyr Ser Ile Ala Ile Thr Gly Asn Phe Gly Leu Met 35 40 45 Tyr Leu Ile Tyr Cys Asp Glu Ala Leu His Arg Pro Met Tyr Val Phe 50 55 60 Leu Ala Leu Leu Ser Phe Thr Asp Val Leu Met Cys Thr Ser Thr Leu 65 70 75 80 Pro Asn Thr Leu Phe Ile Leu Trp Phe Asn Leu Lys Glu Ile Asp Phe 85 90 95 Lys Ala Cys Leu Ala Gln Met Phe Phe Val His Thr Phe Thr Gly Met 100 105 110 Glu Ser Gly Val Leu Met Leu Met Ala Leu Asp His Cys Val Ala Ile 115 120 125 Cys Phe Pro Leu Arg Tyr Ala Thr Ile Leu Thr Asn Ser Val Ile Ala 130 135 140 Lys Ala Gly Phe Leu Thr Phe Leu Arg Gly Val Met Leu Val Ile Pro 145 150 155 160 Ser Thr Phe Leu Thr Lys Arg Leu Pro Tyr Cys Lys Gly Asn Val Ile 165 170 175 Pro His Thr Tyr Cys Asp His Met Ser Val Ala Lys Ile Ser Cys Gly 180 185 190 Asn Val Arg Val Asn Ala Ile Tyr Gly Leu Ile Val Ala Leu Leu Ile 195 200 205 Gly Gly Phe Asp Ile Leu Cys Ile Thr Ile Ser Tyr Thr Met Ile Leu 210 215 220 Gln Ala Val Val Ser Leu Ser Ser Ala Asp Ala Arg Gln Lys Ala Phe 225 230 235 240 Ser Thr Cys Thr Ala His Phe Cys Ala Ile Val Leu Thr Tyr Val Pro 245 250 255 Ala Phe Phe Thr Phe Phe Thr His His Phe Gly Gly His Thr Ile Pro 260 265 270 Leu His Ile His Ile Ile Met Ala Asn Leu Tyr Leu Leu Met Pro Pro 275 280 285 Thr Met Asn Pro Ile Val Tyr Gly Val Lys Thr Arg Gln Val Arg Glu 290 295 300 Ser Val Ile Arg Phe Phe Leu Lys Gly Lys Asp Asn Ser His Asn Phe 305 310 315 320 <210> 207 <211> 948 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(948) <400> 207 atg aca aca cac cga aat gac acc ctc tcc act gaa gct tca gac ttc 48 Met Thr Thr His Arg Asn Asp Thr Leu Ser Thr Glu Ala Ser Asp Phe 1 5 10 15 ctc ttg aat tgt ttt gtc aga tcc ccc agc tgg cag cac tgg ctg tcc 96 Leu Leu Asn Cys Phe Val Arg Ser Pro Ser Trp Gln His Trp Leu Ser 20 25 30 ctg ccc ctc agc ctc ctt ttc ctc ttg gcc gta ggg gcc aac acc acc 144 Leu Pro Leu Ser Leu Leu Phe Leu Leu Ala Val Gly Ala Asn Thr Thr 35 40 45 ctc ctg atg acc atc tgg ctg gag gcc tct ctg cac cag ccc ctg tac 192 Leu Leu Met Thr Ile Trp Leu Glu Ala Ser Leu His Gln Pro Leu Tyr 50 55 60 tac ctg ctc agc ctc ctc tcc ctg ctg gac atc gtg ctc tgc ctc act 240 Tyr Leu Leu Ser Leu Leu Ser Leu Leu Asp Ile Val Leu Cys Leu Thr 65 70 75 80 gtc atc ccc aag gtc ctg acc atc ttc tgg ttt gac ctc agg ccc atc 288 Val Ile Pro Lys Val Leu Thr Ile Phe Trp Phe Asp Leu Arg Pro Ile 85 90 95 agc ttc cct gcc tgc ttc ctc cag atg tac atc atg aat tgt ttc cta 336 Ser Phe Pro Ala Cys Phe Leu Gln Met Tyr Ile Met Asn Cys Phe Leu 100 105 110 gcc atg gag tct tgc aca ttc atg gtc atg gcc tat gat cgt tat gta 384 Ala Met Glu Ser Cys Thr Phe Met Val Met Ala Tyr Asp Arg Tyr Val 115 120 125 gcc atc tgc cac cca ctg aga tat cca tca atc atc act gat cac ttt 432 Ala Ile Cys His Pro Leu Arg Tyr Pro Ser Ile Ile Thr Asp His Phe 130 135 140 gta gtc aag gct gcc atg ttt att ttg acc aga aat gtg ctt atg act 480 Val Val Lys Ala Ala Met Phe Ile Leu Thr Arg Asn Val Leu Met Thr 145 150 155 160 ctg ccc atc ccc atc ctt tca gca caa ctc cgt tat tgt gga aga aat 528 Leu Pro Ile Pro Ile Leu Ser Ala Gln Leu Arg Tyr Cys Gly Arg Asn 165 170 175 gt c att gag aac tgc atc tgt gcc aat atg tct gtt tcc aga ctc tcc 576 Val Ile Glu Asn Cys Ile Cys Ala Asn Met Ser Val Ser Arg Leu Ser 180 185 190 tgc gat gat gtc acc atc aat cac ctt tac caa ttt gct gga ggc tgg 624 Cys Asp Asp Val Thr Ile Asn His Leu Tyr Gln Phe Ala Gly Gly Trp 195 200 205 act ctg cta gga tct gac ctc atc ctt atc ttc ctc tcc tac acc ttc 672 Thr Leu Leu Gly Ser Asp Leu Ile Leu Ile Phe Leu Ser Tyr Thr Phe 210 215 220 att ctg cga gct gtg ctg aga ctc aag gca gag ggt gcc gtg gca aag 720 Ile Leu Arg Ala Val Leu Arg Leu Lys Ala Glu Gly Ala Val Ala Lys 225 230 235 240 gcc cta agc aca tgt ggc tcc cac ttc atg ctc atc ctc ttc ttc agc 768 Ala Leu Ser Thr Cys Gly Ser His Phe Met Leu Ile Leu Phe Phe Ser 245 250 255 acc atc ctt ctg gtt ttt gtc ctc aca cat gtg gct aag aag aaa gtc 816 Thr Ile Leu Leu Val Phe Val Leu Thr His Val Ala Lys Lys Lys Val 260 265 270 tcc cct gat gtg cca gtc ttg ctc aat gtt ctc cac cat gtc att cct 864 Ser Pro Asp Val Pro Val Leu Leu Asn Val Leu His His Val Ile Pro 275 280 285 gca gcc ctt aac ccc atc att tac ggg gtg aga acc caa gaa att aag 912 Ala Ala Leu Asn Pro Ile Ile Tyr Gly Val Arg Thr Gln Glu Ile Lys 290 295 300 cag gga atg cag agg ttg ttg aag aaa ggg tgc taa 948 Gln Gly Met Gln Arg Leu Leu Lys Lys Gly Cys 305 310 315 <210> 208 <211> 315 <212> PRT <213> Homo sapiens <400> 208 Met Thr Thr His Arg Asn Asp Thr Leu Ser Thr Glu Ala Ser Asp Phe 1 5 10 15 Leu Leu Asn Cys Phe Val Arg Ser Pro Ser Trp Gln His Trp Leu Ser 20 25 30 Leu Pro Leu Ser Leu Leu Phe Leu Leu Ala Val Gly Ala Asn Thr Thr 35 40 45 Leu Leu Met Thr Ile Trp Leu Glu Ala Ser Leu His Gln Pro Leu Tyr 50 55 60 Tyr Leu Leu Ser Leu Leu Ser Leu Leu Asp Ile Val Leu Cys Leu Thr 65 70 75 80 Val Ile Pro Lys Val Leu Thr Ile Phe Trp Phe Asp Leu Arg Pro Ile 85 90 95 Ser Phe Pro Ala Cys Phe Leu Gln Met Tyr Ile Met Asn Cys Phe Leu 100 105 110 Ala Met Glu Ser Cys Thr Phe Met Val Met Ala Tyr Asp Arg Tyr Val 115 120 125 Ala Ile Cys His Pro Leu Arg Tyr Pro Ser Ile Ile Thr Asp His Phe 130 135 140 Val Val Lys Ala Ala Met Phe Ile Leu Thr Arg Asn Val Leu Met Thr 145 150 155 160 Leu Pro Ile Pro Ile Leu Ser Ala Gln Leu Arg Tyr Cys Gly Arg Asn 165 170 175 Val Ile Glu Asn Cys Ile Cys Ala Asn Met Ser Val Ser Arg Leu Ser 180 185 190 Cys Asp Asp Val Thr Ile Asn His Leu Tyr Gln Phe Ala Gly Gly Trp 195 200 205 Thr Leu Leu Gly Ser Asp Leu Ile Leu Ile Phe Leu Ser Tyr Thr Phe 210 215 220 Ile Leu Arg Ala Val Leu Arg Leu Lys Ala Glu Gly Ala Val Ala Lys 225 230 235 240 Ala Leu Ser Thr Cys Gly Ser His Phe Met Leu Ile Leu Phe Phe Ser 245 250 255 Thr Ile Leu Leu Val Phe Val Leu Thr His Val Ala Lys Lys Lys Val 260 265 270 Ser Pro Asp Val Pro Val Leu Leu Asn Val Leu His His Val Ile Pro 275 280 285 Ala Ala Leu Asn Pro Ile Ile Tyr Gly Val Arg Thr Gln Glu Ile Lys 290 295 300 Gln Gly Met Gln Arg Leu Leu Lys Lys Gly Cys 305 310 315 <210> 209 <211> 942 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(942) <400> 209 atg cct ata gct aac gac acc cag ttc cat act tct tca ttc cta ctg 48 Met Pro Ile Ala Asn Asp Thr Gln Phe His Thr Ser Ser Phe Leu Leu 1 5 10 15 ctg ggt atc cca ggg cta gaa gat gtg cac atc tgg att gga ttc cct 96 Leu Gly Ile Pro Gly Leu Glu Asp Val His Ile Trp Ile Gly Phe Pro 20 25 30 ttt ttc tct gtg tat ctt att gca ctc ctg gga aat gct gct atc ttc 144 Phe Phe Ser Val Tyr Leu Ile Ala Leu Leu Gly Asn Ala Ala Ile Phe 35 40 45 ttt gtg atc caa act gag cag agt ctc cat gag ccc atg tac tac tgc 192 Phe Val Ile Gln Thr Glu Gln Ser Leu His Glu Pro Met Tyr Tyr Cys 50 55 60 ctg gcc atg ttg gat tcc att gac ctg agc ttg tct acg gcc acc att 240 Leu Ala Met Leu Asp Ser Ile Asp Leu Ser Leu Ser Thr Ala Thr Ile 65 70 75 80 ccc aaa atg ctg ggc atc ttc tgg ttc aat atc aag gaa ata tct ttt 288 Pro Lys Met Leu Gly Ile Phe Trp Phe Asn Ile Lys Glu Ile Ser Phe 85 90 95 gga ggc tac ctt tct cag atg ttc ttc atc cat ttc ttc act gtc atg 336 Gly Gly Tyr Leu Ser Gln Met Phe Phe Ile His Phe Phe Thr Val Met 100 105 110 gag agc atc gta ttg gtg gcc atg gcc ttt gac cgc tac att gcc att 384 Glu Ser Ile Val Leu Val Ala Met Ala Phe Asp Arg Tyr Ile Ala Ile 115 120 125 tgc aaa cct ctt tgg tac acc atg atc ctc acc agc aaa atc atc agc 432 Cys Lys Pro Leu Trp Tyr Thr Met Ile Leu Thr Ser Lys Ile Ile Ser 130 135 140 ctc att gca ggc att gct gtc ctg agg agc ttg tac atg gtc att cca 480 Leu Ile Ala Gly Ile Ala Val Leu Arg Ser Leu Tyr Met Val Ile Pro 145 150 155 160 ctg gtg ttt ctc ctc tta agg ttg ccc ttc tgt gga cat cgt atc atc 528 Leu Val Phe Leu Leu Leu Arg Leu Pro Phe Cys Gly His Arg Ile Ile 165 170 175 cct cat act tac tgt gag cac atg ggc att gcc cgt ctg gcc tgt gcc 576 Pro His Thr Tyr Cys Glu His Met Gly Ile Ala Arg Leu Ala Cys Ala 180 185 190 agc atc aaa gtc aac att atg ttt ggt ctt ggc agt att tct ctc ttg 624 Ser Ile Lys Val Asn Ile Met Phe Gly Leu Gly Ser Ile Ser Leu Leu 195 200 205 tta ttg gat gtg ctc ctt att att ctc tcc cat atc agg atc ctc tat 672 Leu Leu Asp Val Leu Leu Ile Ile Leu Ser His Ile Arg Ile Leu Tyr 210 215 220 gct gtc ttc tgc ctg ccc tcc tgg gaa gct cga ctc aaa gct ctc aac 720 Ala Val Phe Cys Leu Pro Ser Trp Glu Ala Arg Leu Lys Ala Leu Asn 225 230 235 240 acc tgt ggc tct cac att ggt gtt atc tta gcc ttt tct aca cca gca 768 Thr Cys Gly Ser His Ile Gly Val Ile Leu Ala Phe Ser Thr Pro Ala 245 250 255 ttt ttc tct ttc ttt aca cac tgc ttt ggc cat gat att ccc caa tat 816 Phe Phe Ser Phe Phe Thr His Cys Phe Gly His Asp Ile Pro Gln Tyr 260 265 270 atc cac att ttc ttg gct aat cta tat gtg gtt gtt cct ccc acc ctc 864 Ile His Ile Phe Leu Ala Asn Leu Tyr Val Val Val Pro Pro Thr Leu 275 280 285 aat cct gta atc tat ggg gtc aga acc aaa cat att agg gag aca gtg 912 Asn Pro Val Ile Tyr Gly Val Arg Thr Lys His Ile Arg Glu Thr Val 290 295 300 ctg agg att ttc ttc aag aca gat cac taa 942 Leu Arg Ile Phe Phe Lys Thr Asp His 305 310 <210> 210 <211> 313 <212> PRT <213> Homo sapiens <400> 210 Met Pro Ile Ala Asn Asp Thr Gln Phe His Thr Ser Ser Phe Leu Leu 1 5 10 15 Leu Gly Ile Pro Gly Leu Glu Asp Val His Ile Trp Ile Gly Phe Pro 20 25 30 Phe Phe Ser Val Tyr Leu Ile Ala Leu Leu Gly Asn Ala Ala Ile Phe 35 40 45 Phe Val Ile Gln Thr Glu Gln Ser Leu His Glu Pro Met Tyr Tyr Cys 50 55 60 Leu Ala Met Leu Asp Ser Ile Asp Leu Ser Leu Ser Thr Ala Thr Ile 65 70 75 80 Pro Lys Met Leu Gly Ile Phe Trp Phe Asn Ile Lys Glu Ile Ser Phe 85 90 95 Gly Gly Tyr Leu Ser Gln Met Phe Phe Ile His Phe Phe Thr Val Met 100 105 110 Glu Ser Ile Val Leu Val Ala Met Ala Phe Asp Arg Tyr Ile Ala Ile 115 120 125 Cys Lys Pro Leu Trp Tyr Thr Met Ile Leu Thr Ser Lys Ile Ile Ser 130 135 140 Leu Ile Ala Gly Ile Ala Val Leu Arg Ser Leu Tyr Met Val Ile Pro 145 150 155 160 Leu Val Phe Leu Leu Leu Arg Leu Pro Phe Cys Gly His Arg Ile Ile 165 170 175 Pro His Thr Tyr Cys Glu His Met Gly Ile Ala Arg Leu Ala Cys Ala 180 185 190 Ser Ile Lys Val Asn Ile Met Phe Gly Leu Gly Ser Ile Ser Leu Leu 195 200 205 Leu Leu Asp Val Leu Leu Ile Ile Leu Ser His Ile Arg Ile Leu Tyr 210 215 220 Ala Val Phe Cys Leu Pro Ser Trp Glu Ala Arg Leu Lys Ala Leu Asn 225 230 235 240 Thr Cys Gly Ser His Ile Gly Val Ile Leu Ala Phe Ser Thr Pro Ala 245 250 255 Phe Phe Ser Phe Phe Thr His Cys Phe Gly His Asp Ile Pro Gln Tyr 260 265 270 Ile His Ile Phe Leu Ala Asn Leu Tyr Val Val Val Pro Pro Thr Leu 275 280 285 Asn Pro Val Ile Tyr Gly Val Arg Thr Lys His Ile Arg Glu Thr Val 290 295 300 Leu Arg Ile Phe Phe Lys Thr Asp His 305 310 <210> 211 <211> 954 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(954) <400> 211 atg gca gga aga atg tct acg tct aat cac acc cag ttc cat cct tct 48 Met Ala Gly Arg Met Ser Thr Ser Asn His Thr Gln Phe His Pro Ser 1 5 10 15 tca ttc cta ctg ctg ggt atc cca ggg cta gaa gat gtg cac att tgg 96 Ser Phe Leu Leu Leu Gly Ile Pro Gly Leu Glu Asp Val His Ile Trp 20 25 30 att gga gtc cct ttt ttc ttt gtg tat ctt gtt gca ctc ctg gga aac 144 Ile Gly Val Pro Phe Phe Phe Val Tyr Leu Val Ala Leu Leu Gly Asn 35 40 45 act gct ctc ttg ttt gtg atc cag act gag cag agt ctc cat gag cct 192 Thr Ala Leu Leu Phe Val Ile Gln Thr Glu Gln Ser Leu His Glu Pro 50 55 60 atg tac tac ttc ctg gcc atg ttg gat tcc att gac ctg ggc ttg tct 240 Met Tyr Tyr Phe Leu Ala Met Leu Asp Ser Ile Asp Leu Gly Leu Ser 65 70 75 80 aca gcc acc atc ccc aaa atg ttg ggc atc ttc tgg ttc aat acc aaa 288 Thr Ala Thr Ile Pro Lys Met Leu Gly Ile Phe Trp Phe Asn Thr Lys 85 90 95 gaa ata tct ttt gga ggc tgc ctt tct cac atg ttc ttc atc cat ttc 336 Glu Ile Ser Phe Gly Gly Cys Leu Ser His Met Phe Phe Ile His Phe 100 105 110 ttc act gct atg gag agc att gtg ttg gtg gcc atg gcc ttt gac cgc 384 Phe Thr Ala Met Glu Ser Ile Val Leu Val Ala Met Ala Phe Asp Arg 115 120 125 tac att gcc att tgc aaa cct ctt cgg tac acc atg atc ctc acc agc 432 Tyr Ile Ala Ile Cys Lys Pro Leu Arg Tyr Thr Met Ile Leu Thr Ser 130 135 140 aaa atc atc agc ctc att gca ggc att gct gtc ctg agg agc ctg tac 480 Lys Ile Ile Ser Leu Ile Ala Gly Ile Ala Val Leu Arg Ser Leu Tyr 145 150 155 160 atg gtt gtt cca ctg gtg ttt ctc ctt ctg agg ctg ccc ttc tgt ggg 528 Met Val Val Pro Leu Val Phe Leu Leu Leu Arg Leu Pro Phe Cys Gly 165 170 175 cat cgt atc atc cct cat act tat tgt gag cac atg ggc att gcc cgt 576 His Arg Ile Ile Pro His Thr Tyr Cys Glu His Met Gly Ile Ala Arg 180 185 190 ctg gcc tgt gcc agc atc aaa gtc aac att agg ttt ggc ctt ggc aac 624 Leu Ala Cys Ala Ser Ile Lys Val Asn Ile Arg Phe Gly Leu Gly Asn 195 200 205 ata tct ctc ttg tta ctg gat gtt atc ctt att att ctc tcc tat gtc 672 Ile Ser Leu Leu Leu Leu Asp Val Ile Leu Ile Ile Leu Ser Tyr Val 210 215 220 agg atc ctg tat gct gtc ttc tgc ctg ccc tcc tgg gaa gct cga ctc 720 Arg Ile Leu Tyr Ala Val Phe Cys Leu Pro Ser Trp Glu Ala Arg Leu 225 230 235 240 aaa gct ctc aac acc tgt ggt tct cat att ggt gtt atc tta gcc ttt 768 Lys Ala Leu Asn Thr Cys Gly Ser His Ile Gly Val Ile Leu Ala Phe 245 250 255 ttt aca cca gca ttt ttt tca ttc ttg aca cat cgt ttt ggc cat aat 816 Phe Thr Pro Ala Phe Phe Ser Phe Leu Thr His Arg Phe Gly His Asn 260 265 270 atc cca cag tat ata cat att ata tta gcc aac ctg tat gtg gtt gtc 864 Ile Pro Gln Tyr Ile His Ile Ile Leu Ala Asn Leu Tyr Val Val Val 275 280 285 cca cca gcc ctc aat cct gta atc tat gga gtc agg aca aag cag att 912 Pro Pro Ala Leu Asn Pro Val Ile Tyr Gly Val Arg Thr Lys Gln Ile 290 295 300 cga gag aga gtg ctg agg att ttt ctc aag acc aat cac taa 954 Arg Glu Arg Val Leu Arg Ile Phe Leu Lys Thr Asn His 305 310 315 <210> 212 <211> 317 <212> PRT <213> Homo sapiens <400> 212 Met Ala Gly Arg Met Ser Thr Ser Asn His Thr Gln Phe His Pro Ser 1 5 10 15 S er Phe Leu Leu Leu Gly Ile Pro Gly Leu Glu Asp Val His Ile Trp 20 25 30 Ile Gly Val Pro Phe Phe Phe Val Tyr Leu Val Ala Leu Leu Gly Asn 35 40 45 Thr Ala Leu Leu Phe Val Ile Gln Thr Glu Gln Ser Leu His Glu Pro 50 55 60 Met Tyr Tyr Phe Leu Ala Met Leu Asp Ser Ile Asp Leu Gly Leu Ser 65 70 75 80 Thr Ala Thr Ile Pro Lys Met Leu Gly Ile Phe Trp Phe Asn Thr Lys 85 90 95 Glu Ile Ser Phe Gly Gly Cys Leu Ser His Met Phe Phe Ile His Phe 100 105 110 Phe Thr Ala Met Glu Ser Ile Val Leu Val Ala Met Ala Phe Asp Arg 115 120 125 Tyr Ile Ala Ile Cys Lys Pro Leu Arg Tyr Thr Met Ile Leu Thr Ser 130 135 140 Lys Ile Ile Ser Leu Ile Ala Gly Ile Ala Val Leu Arg Ser Leu Tyr 145 150 155 160 Met Val Val Pro Leu Val Phe Leu Leu Leu Arg Leu Pro Phe Cys Gly 165 170 175 His Arg Ile Ile Pro His Thr Tyr Cys Glu His Met Gly Ile Ala Arg 180 185 190 Leu Ala Cys Ala Ser Ile Lys Val Asn Ile Arg Phe Gly Leu Gly Asn 195 200 205 Ile Ser Leu Leu Leu Leu Asp Val Ile Leu Ile Ile Leu Ser Tyr Val 210 215 220 Arg Ile Leu Tyr Ala Val Phe Cys Leu Pro Ser Trp Glu Ala Arg Leu 225 230 235 240 Lys Ala Leu Asn Thr Cys Gly Ser His Ile Gly Val Ile Leu Ala Phe 245 250 255 Phe Thr Pro Ala Phe Phe Ser Phe Leu Thr His Arg Phe Gly His Asn 260 265 270 Ile Pro Gln Tyr Ile His Ile Ile Leu Ala Asn Leu Tyr Val Val Val 275 280 285 Pro Pro Ala Leu Asn Pro Val Ile Tyr Gly Val Arg Thr Lys Gln Ile 290 295 300 Arg Glu Arg Val Leu Arg Ile Phe Leu Lys Thr Asn His 305 310 315 <210> 213 <211> 936 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(936) <400> 213 atg ttt tat cac aac aag agc ata ttt cac cca gtc aca ttt ttc ctc 48 Met Phe Tyr His Asn Lys Ser Ile Phe His Pro Val Thr Phe Phe Leu 1 5 10 15 att gga atc cca ggt ctg gaa gac ttc cac atg tgg atc tcc ggg cct 96 Ile Gly Ile Pro Gly Leu Glu Asp Phe His Met Trp Ile Ser Gly Pro 20 25 30 ttc tgc tct gtt tac ctt gtg gct ttg ctg ggc aat gcc acc att ctg 144 Phe Cys Ser Val Tyr Leu Val Ala Leu Leu Gly Asn Ala Thr Ile Leu 35 40 45 cta gtc atc aag gta gaa cag act ctc cgg gag ccc atg ttc tac ttc 192 Leu Val Ile Lys Val Glu Gln Thr Leu Arg Glu Pro Met Phe Tyr Phe 50 55 60 ctg gcc att ctt tcc act att gat ttg gcc ctt tct gca acc tct gtg 240 Leu Ala Ile Leu Ser Thr Ile Asp Leu Ala Leu Ser Ala Thr Ser Val 65 70 75 80 cct cgc atg ctg ggt atc ttc tgg ttt gat gct cac gag att aac tat 288 Pro Arg Met Leu Gly Ile Phe Trp Phe Asp Ala His Glu Ile Asn Tyr 85 90 95 gga gct tgt gtg gcc cag atg ttt ctg atc cat gcc ttc act ggc atg 336 Gly Ala Cys Val Ala Gln Met Phe Leu Ile His Ala Phe Thr Gly Met 100 105 110 gag gct gag gtc tta ctg gct atg gct ttt gac cgt tat gtg gcc atc 384 Glu Ala Glu Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile 115 120 125 tgt gct cca cta cat tac gca acc atc ttg aca tcc cta gtg ttg gtg 432 Cys Ala Pro Leu His Tyr Ala Thr Ile Leu Thr Ser Leu Val Leu Val 130 135 140 ggc att agc atg tgc att gta att cgt ccc gtt tta ctt aca ctt ccc 480 Gly Ile Ser Met Cys Ile Val Ile Arg Pro Val Leu Leu Thr Leu Pro 145 150 155 160 atg gtc tat ctt atc tac cgc cta ccc ttt tgt cag gct cac ata ata 528 Met Val Tyr Leu Ile Tyr Arg Leu Pro Phe Cys Gln Ala His Ile Ile 165 170 175 gcc cat tcc tac tgt gag cac atg ggc att gca aaa ttg tcc tgt gga 576 Ala His Ser Tyr Cys Glu His Met Gly Ile Ala Lys Leu Ser Cys Gly 180 185 190 aac att cgt atc aat ggt atc tat ggg ctt ttt gta gtt tct ttc ttt 624 Asn Ile Arg Ile Asn Gly Ile Tyr Gly Leu Phe Val Val Ser Phe Phe 195 200 205 gtt ctg aac ctg gtg ctc att ggc atc tcg tat gtt tac att ctc cgt 672 Val Leu Asn Leu Val Leu Ile Gly Ile Ser Tyr Val Tyr Ile Leu Arg 210 215 220 gct gtc ttc cgc ctc cca tca cat gat gct cag cta aaa gcc cta agc 720 Ala Val Phe Arg Leu Pro Ser His Asp Ala Gln Leu Lys Ala Leu Ser 225 230 235 240 acg tgt ggc gct cat gtt gga gtc atc tgt gtt ttc tat atc cct tca 768 Thr Cys Gly Ala His Val Gly Val Ile Cys Val Phe Tyr Ile Pro Ser 245 250 255 gtc ttc tct ttc ctt act cat cga ttt gga cac caa ata cca ggt tac 816 Val Phe Ser Phe Leu Thr His Arg Phe Gly His Gln Ile Pro Gly Tyr 260 265 270 att cac att ctt gtt gcc aat ctc tat ttg att atc cca ccc tct ctc 864 Ile His Ile Leu Val Ala Asn Leu Tyr Leu Ile Ile Pro Pro Ser Leu 275 280 285 aac ccc atc att tat ggg gtg agg acc aaa cag att cga gag cga gtg 912 Asn Pro Ile Ile Tyr Gly Val Arg Thr Lys Gln Ile Arg Glu Arg Val 290 295 300 ctc tat gtt ttt act aaa aaa taa 936 Leu Tyr Val Phe Thr Lys Lys 305 310 <210> 214 <211> 311 <212> PRT <213> Homo sapiens <400> 214 Met Phe Tyr His Asn Lys Ser Ile Phe His Pro Val Thr Phe Phe Leu 1 5 10 15 Ile Gly Ile Pro Gly Leu Glu Asp Phe His Met Trp Ile Ser Gly Pro 20 25 30 Phe Cys Ser Val Tyr Leu Val Ala Leu Leu Gly Asn Ala Thr Ile Leu 35 40 45 Leu Val Ile Lys Val Glu Gln Thr Leu Arg Glu Pro Met Phe Tyr Phe 50 55 60 Leu Ala Ile Leu Ser Thr Ile Asp Leu Ala Leu Ser Ala Thr Ser Val 65 70 75 80 Pro Arg Met Leu Gly Ile Phe Trp Phe Asp Ala His Glu Ile Asn Tyr 85 90 95 Gly Ala Cys Val Ala Gln Met Phe Leu Ile His Ala Phe Thr Gly Met 100 105 110 Glu Ala Glu Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile 115 120 125 Cys Ala Pro Leu His Tyr Ala Thr Ile Leu Thr Ser Leu Val Leu Val 130 135 140 Gly Ile Ser Met Cys Ile Val Ile Arg Pro Val Leu Leu Thr Leu Pro 145 150 155 160 Met Val Tyr Leu Ile Tyr Arg Leu Pro Phe Cys Gln Ala His Ile Ile 165 170 175 Ala His Ser Tyr Cys Glu His Met Gly Ile Ala Lys Leu Ser Cys Gly 180 185 190 Asn Ile Arg Ile Asn Gly Ile Tyr Gly Leu Phe Val Val Ser Phe Phe 195 200 205 Val Leu Asn Leu Val Leu Ile Gly Ile Ser Tyr Val Tyr Ile Leu Arg 210 215 220 Ala Val Phe Arg Leu Pro Ser His Asp Ala Gln Leu Lys Ala Leu Ser 225 230 235 240 Thr Cys Gly Ala His Val Gly Val Ile Cys Val Phe Tyr Ile Pro Ser 245 250 255 Val Phe Ser Phe Leu Thr His Arg Phe Gly His Gln Ile Pro Gly Tyr 260 265 270 Ile His Ile Leu Val Ala Asn Leu Tyr Leu Ile Ile Pro Pro Ser Leu 275 280 285 Asn Pro Ile Ile Tyr Gly Val Arg Thr Lys Gln Ile Arg Glu Arg Val 290 295 300 Leu Tyr Val Phe Thr Lys Lys 305 310 <210> 215 <211> 927 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(927) <400> 215 atg aat acc act cta ttt cat cct tac tct ttc ctt ctt ctg gga att 48 Met Asn Thr Thr Leu Phe His Pro Tyr Ser Phe Leu Leu Leu Gly Ile 1 5 10 15 cct ggg ctg gaa agt atg cat ctc tgg gtt ggt ttt cct ttc ttt gct 96 Pro Gly Leu Glu Ser Met His Leu Trp Val Gly Phe Pro Phe Phe Ala 20 25 30 gtg ttc ctg aca gct gtc ctt ggg aat atc acc atc ctt ttt gtg att 144 Val Phe Leu Thr Ala Val Leu Gly Asn Ile Thr Ile Leu Phe Val Ile 35 40 45 cag act gac agt agt ctc cat cat ccc atg ttc tac ttc ctg gcc att 192 Gln Thr Asp Ser Ser Leu His His Pro Met Phe Tyr Phe Leu Ala Ile 50 55 60 ctg tca tct att gac ccg ggc ctg tct aca tcc acc atc cct aaa atg 240 Leu Ser Ser Ile Asp Pro Gly Leu Ser Thr Ser Thr Ile Pro Lys Met 65 70 75 80 ctt ggc acc ttc tgg ttt acc ctg aga gaa atc tcc ttt gaa gga tgc 288 Leu Gly Thr Phe Trp Phe Thr Leu Arg Glu Ile Ser Phe Glu Gly Cys 85 90 95 ctt acc cag atg ttc ttc atc cac ctg tgc act ggc atg gaa tca gct 336 Leu Thr Gln Met Phe Phe Ile His Leu Cys Thr Gly Met Glu Ser Ala 100 105 110 gtg ctt gtg gcc atg gcc tat gat tgc tat gtg gcc atc tgt gac cct 384 Val Leu Val Ala Met Ala Tyr Asp Cys Tyr Val Ala Ile Cys Asp Pro 115 120 125 ctt tgc tac acg ttg gtg ctg aca aac aag gtg gtg tca gtt atg gca 432 Leu Cys Tyr Thr Leu Val Leu Thr Asn Lys Val Val Ser Val Met Ala 130 135 140 ctg gcc atc ttt ctg aga ccc tta gtc ttt gtc ata ccc ttt gtt cta 480 Leu Ala Ile Phe Leu Arg Pro Leu Val Phe Val Ile Pro Phe Val Leu 145 150 155 160 ttt atc cta agg ctt cca ttt tgt gga cac caa att att cct cat act 528 Phe Ile Leu Arg Leu Pro Phe Cys Gly His Gln Ile Ile Pro His Thr 165 170 175 tat ggt gag cac atg ggc att gcc cgc ctg tct tgt gcc agc atc agg 576 Tyr Gly Glu His Met Gly Ile Ala Arg Leu Ser Cys Ala Ser Ile Arg 180 185 190 gtt aac atc atc tat ggc tta tgt gcc atc tct atc ctg gtc ttt gac 624 Val Asn Ile Ile Tyr Gly Leu Cys Ala Ile Ser Ile Leu Val Phe Asp 195 200 205 atc ata gca att gtc att tcc tat gta cag atc ctt tgt gct gta ttt 672 Ile Ile Ala Ile Val Ile Ser Tyr Val Gln Ile Leu Cys Ala Val Phe 210 215 220 cta ctc tct tca cat gat gca cga ctc aag gca ttc agc acc tgt ggc 720 Leu Leu Ser Ser His Asp Ala Arg Leu Lys Ala Phe Ser Thr Cys Gly 225 230 235 240 tct cat gtg tgt gtc atg ttg act ttc tat atg cct gca ttt ttc tca 768 Ser His Val Cys Val Met Leu Thr Phe Tyr Met Pro Ala Phe Phe Ser 245 250 255 ttc atg acc cat agg ttt ggt cgg aat ata cct cac ttt atc cac att 816 Phe Met Thr His Arg Phe Gly Arg Asn Ile Pro His Phe Ile His Ile 260 265 270 ctt ctg gct aat ttc tat gta gtc att cca cct gct ctc aac tct gta 864 Leu Leu Ala Asn Phe Tyr Val Val Ile Pro Pro Ala Leu Asn Ser Val 275 280 285 att tat ggt gtc aga acc aaa cag att aga gca caa gtg ctg aaa atg 912 Ile Tyr Gly Val Arg Thr Lys Gln Ile Arg Ala Gln Val Leu Lys Met 290 295 300 ttt ttc aat aaa taa 927 Phe Phe Asn Lys 305 <210> 216 <211> 308 <212> PRT <213> Homo sapiens <400> 216 Met Asn Thr Thr Leu Phe His Pro Tyr Ser Phe Leu Leu Leu Gly Ile 1 5 10 15 Pro Gly Leu Glu Ser Met His Leu Trp Val Gly Phe Pro Phe Phe Ala 20 25 30 Val Phe Leu Thr Ala Val Leu Gly Asn Ile Thr Ile Leu Phe Val Ile 35 40 45 Gln Thr Asp Ser Ser Leu His His Pro Met Phe Tyr Phe Leu Ala Ile 50 55 60 Leu Ser Ser Ile Asp Pro Gly Leu Ser Thr Ser Thr Ile Pro Lys Met 65 70 75 80 Leu Gly Thr Phe Trp Phe Thr Leu Arg Glu Ile Ser Phe Glu Gly Cys 85 90 95 Leu Thr Gln Met Phe Phe Ile His Leu Cys Thr Gly Met Glu Ser Ala 100 105 110 Val Leu Val Ala Met Ala Tyr Asp Cys Tyr Val Ala Ile Cys Asp Pro 115 120 125 Leu Cys Tyr Thr Leu Val Leu Thr Asn Lys Val Val Ser Val Met Ala 130 135 140 Leu Ala Ile Phe Leu Arg Pro Leu Val Phe Val Ile Pro Phe Val Leu 145 150 155 160 Phe Ile Leu Arg Leu Pro Phe Cys Gly His Gln Ile Ile Pro His Thr 165 170 175 Tyr Gly Glu His Met Gly Ile Ala Arg Leu Ser Cys Ala Ser Ile Arg 180 185 190 Val Asn Ile Ile Tyr Gly Leu Cys Ala Ile Ser Ile Leu Val Phe Asp 195 200 205 Ile Ile Ala Ile Val Ile Ser Tyr Val Gln Ile Leu Cys Ala Val Phe 210 215 220 Leu Leu Ser Ser His Asp Ala Arg Leu Lys Ala Phe Ser Thr Cys Gly 225 230 235 240 Ser His Val Cys Val Met Leu Thr Phe Tyr Met Pro Ala Phe Phe Ser 245 250 255 Phe Met Thr His Arg Phe Gly Arg Asn Ile Pro His Phe Ile His Ile 260 265 270 Leu Leu Ala Asn Phe Tyr Val Val Ile Pro Pro Ala Leu Asn Ser Val 275 280 285 Ile Tyr Gly Val Arg Thr Lys Gln Ile Arg Ala Gln Val Leu Lys Met 290 295 300 Phe Phe Asn Lys 305 <210> 217 <211> 948 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(948) <400> 217 atg gga gac tgg aat aac agt gat gct gtg gag ccc ata ttt atc ctg 48 Met Gly Asp Trp Asn Asn Ser Asp Ala Val Glu Pro Ile Phe Ile Leu 1 5 10 15 agg ggt ttt cct gga ctg gag tat gtt cat tct tgg ctc tcc atc ctc 96 Arg Gly Phe Pro Gly Leu Glu Tyr Val His Ser Trp Leu Ser Ile Leu 20 25 30 ttc tgt ctt gca tat ttg gta gca ttt atg ggt aat gtt acc atc ctg 144 Phe Cys Leu Ala Tyr Leu Val Ala Phe Met Gly Asn Val Thr Ile Leu 35 40 45 tct gtc att tgg ata gaa tcc tct ctc cat cag ccc atg tat tac ttt 192 Ser Val Ile Trp Ile Glu Ser Ser Leu His Gln Pro Met Tyr Tyr Phe 50 55 60 att tcc atc tta gca gtg aat gac ctg ggg atg tcc ctg tct aca ctt 240 Ile Ser Ile Leu Ala Val Asn Asp Leu Gly Met Ser Leu Ser Thr Leu 65 70 75 80 ccc acc atg ctt gct gtg tta tgg ttg gat gct cca gag atc cag gca 288 Pro Thr Met Leu Ala Val Leu Trp Leu Asp Ala Pro Glu Ile Gln Ala 85 90 95 agt gct tgc tat gct cag ctg ttc ttc atc cac aca ttc aca ttc ctg 336 Ser Ala Cys Tyr Ala Gln Leu Phe Phe Ile His Thr Phe Thr Phe Leu 100 105 110 gag tcc tca gtg ttg ctg gcc atg gcc ttt gac cgt ttt gtt gct atc 384 Glu Ser Ser Val Leu Leu Ala Met Ala Phe Asp Arg Phe Val Ala Ile 115 120 125 tgc cat cca ctg cac tac ccc acc atc ctc acc aac agt gta att ggc 432 Cys His Pro Leu His Tyr Pro Thr Ile Leu Thr Asn Ser Val Ile Gly 130 135 140 aaa att ggt ttg gcc tgt ttg cta cga agc ttg gga gtt gta ctt ccc 480 Lys Ile Gly Leu Ala Cys Leu Leu Arg Ser Leu Gly Val Val Leu Pro 145 150 155 160 aca cct ttg cta ctg aga cac tat cac tac tgc cat ggc aat gcc ctc 528 Thr Pro Leu Leu Leu Arg His Tyr His Tyr Cys His Gly Asn Ala Leu 165 170 175 tct cac gcc ttc tgt ttg cac cag gat gtt cta aga tta tcc tgt aca 576 Ser His Ala Phe Cys Leu His Gln Asp Val Leu Arg Leu Ser Cys Thr 180 185 190 gat gcc agg acc aac agt att tat ggg ctt tgt gta gtc att gcc aca 624 Asp Ala Arg Thr Asn Ser Ile Tyr Gly Leu Cys Val Val Ile Ala Thr 195 200 205 cta ggt gtg gat tca atc ttc ata ctt ctt tct tat gtt ctg att ctt 672 Leu Gly Val Asp Ser Ile Phe Ile Leu Leu Ser Tyr Val Leu Ile Leu 210 215 220 aat act gtg ctg gat att gca tct cgt gaa gag cag cta aag gca ctc 720 Asn Thr Val Leu Asp Ile Ala Ser Arg Glu Glu Gln Leu Lys Ala Leu 225 230 235 240 aac aca tgt gta tcc cat atc tgt gtg gtg ctt atc ttc ttt gtg cca 768 Asn Thr Cys Val Ser His Ile Cys Val Val Leu Ile Phe Phe Val Pro 245 250 255 gtt att ggg gtg tca atg gtc cat cgc ttt ggg aag cat ctg tct ccc 816 Val Ile Gly Val Ser Met Val His Arg Phe Gly Lys His Leu Ser Pro 260 265 270 ata gtc cac atc ctc atg gca gac atc tac ctt ctt ctt ccc cca gtc 864 Ile Val His Ile Leu Met Ala Asp Ile Tyr Leu Leu Leu Pro Pro Val 275 280 285 ctt aac cct att gtc tat agt gtc aga aca aag cag att cgt cta gga 912 Leu Asn Pro Ile Val Tyr Ser Val Arg Thr Lys Gln Ile Arg Leu Gly 290 295 300 att ctc cac aag ttt gtc cta agg agg agg ttt taa 948 Ile Leu His Lys Phe Val Leu Arg Arg Arg Phe 305 310 315 <210> 218 <211> 315 <212> PRT <213> Homo sapiens <400> 218 Met Gly Asp Trp Asn Asn Ser Asp Ala Val Glu Pro Ile Phe Ile Leu 1 5 10 15 Arg Gly Phe Pro Gly Leu Glu Tyr Val His Ser Trp Leu Ser Ile Leu 20 25 30 Phe Cys Leu Ala Tyr Leu Val Ala Phe Met Gly Asn Val Thr Ile Leu 35 40 45 Ser Val Ile Trp Ile Glu Ser Ser Leu His Gln Pro Met Tyr Tyr Phe 50 55 60 Ile Ser Ile Leu Ala Val Asn Asp Leu Gly Met Ser Leu Ser Thr Leu 65 70 75 80 Pro Thr Met Leu Ala Val Leu Trp Leu Asp Ala Pro Glu Ile Gln Ala 85 90 95 Ser Ala Cys Tyr Ala Gln Leu Phe Phe Ile His Thr Phe Thr Phe Leu 100 105 110 Glu Ser Ser Val Leu Leu Ala Met Ala Phe Asp Arg Phe Val Ala Ile 115 120 125 Cys His Pro Leu His Tyr Pro Thr Ile Leu Thr Asn Ser Val Ile Gly 130 135 140 Lys Ile Gly Leu Ala Cys Leu Leu Arg Ser Leu Gly Val Val Leu Pro 145 150 155 160 Thr Pro Leu Leu Leu Arg His Tyr His Tyr Cys His Gly Asn Ala Leu 165 170 175 Ser His Ala Phe Cys Leu His Gln Asp Val Leu Arg Leu Ser Cys Thr 180 185 190 Asp Ala Arg Thr Asn Ser Ile Tyr Gly Leu Cys Val Val Ile Ala Thr 195 200 205 Leu Gly Val Asp Ser Ile Phe Ile Leu Leu Ser Tyr Val Leu Ile Leu 210 215 220 Asn Thr Val Leu Asp Ile Ala Ser Arg Glu Glu Gln Leu Lys Ala Leu 225 230 235 240 Asn Thr Cys Val Ser His Ile Cys Val Val Leu Ile Phe Phe Val Pro 245 250 255 Val Ile Gly Val Ser Met Val His Arg Phe Gly Lys His Leu Ser Pro 260 265 270 Ile Val His Ile Leu Met Ala Asp Ile Tyr Leu Leu Leu Pro Pro Val 275 280 285 Leu Asn Pro Ile Val Tyr Ser Val Arg Thr Lys Gln Ile Arg Leu Gly 290 295 300 Ile Leu His Lys Phe Val Leu Arg Arg Arg Phe 305 310 315 <210> 219 <211> 978 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(978) <400> 219 atg ttc ctt ccc aat gac acc cag ttt cac ccc tcc tcc ttc ctg ttg 48 Met Phe Leu Pro Asn Asp Thr Gln Phe His Pro Ser Ser Phe Leu Leu 1 5 10 15 ctg ggg atc cca gga cta gaa aca ctt cac atc tgg atc ggc ttt ccc 96 Leu Gly Ile Pro Gly Leu Glu Thr Leu His Ile Trp Ile Gly Phe Pro 20 25 30 ttc tgt gct gtg tac atg atc gca ctc ata ggg aac ttc act att cta 144 Phe Cys Ala Val Tyr Met Ile Ala Leu Ile Gly Asn Phe Thr Ile Leu 35 40 45 ctt gtg atc aag act gac agc agc cta cac cag ccc atg ttc tac ttc 192 Leu Val Ile Lys Thr Asp Ser Ser Leu His Gln Pro Met Phe Tyr Phe 50 55 60 ctg gcc atg ttg gcc acc act gat gtg ggt ctc tca aca gct acc atc 240 Leu Ala Met Leu Ala Thr Thr Asp Val Gly Leu Ser Thr Ala Thr Ile 65 70 75 80 cct aag atg ctt gga atc ttc tgg atc aac ctc aga ggg atc atc ttt 288 Pro Lys Met Leu Gly Ile Phe Trp Ile Asn Leu Arg Gly Ile Ile Phe 85 90 95 gaa gcc tgc ctc acc cag atg ttt ttt atc cac aac ttc aca ctt atg 336 Glu Ala Cys Leu Thr Gln Met Phe Phe Ile His Asn Phe Thr Leu Met 100 105 110 gag tca gca gtc ctt gtg gca atg gct tat gac agc tat gtg gcc atc 384 Glu Ser Ala Val Leu Val Ala Met Ala Tyr Asp Ser Tyr Val Ala Ile 115 120 125 tgc aat cca ctc caa tat agc gcc atc ctc acc aac aag gtt gtt tct 432 Cys Asn Pro Leu Gln Tyr Ser Ala Ile Leu Thr Asn Lys Val Val Ser 130 135 140 gtg att ggt ctt ggt gtg ttt gtg agg gct tta att ttc gtc att ccc 480 Val Ile Gly Leu Gly Val Phe Val Arg Ala Leu Ile Phe Val Ile Pro 145 150 155 160 tct ata ctt ctt ata ttg cgg ttg ccc ttc tgt ggg aat cat gta att 528 Ser Ile Leu Leu Ile Leu Arg Leu Pro Phe Cys Gly Asn His Val Ile 165 170 175 ccc cac acc tac tgt gag cac atg ggt ctt gct cat cta tct tgt gcc 576 Pro His Thr Tyr Cys Glu His Met Gly Leu Ala His Leu Ser Cys Ala 180 185 190 agc atc aaa atc aat att att tat ggt tta tgt gcc att tgt aat ctg 624 Ser Ile Lys Ile Asn Ile Ile Tyr Gly Leu Cys Ala Ile Cys Asn Leu 195 200 205 gtg ttt gac atc aca gtc att gcc ctc tct tat gtg cat att ctt tgt 672 Val Phe Asp Ile Thr Val Ile Ala Leu Ser Tyr Val His Ile Leu Cys 210 215 220 gct gtt ttc cgt ctt cct act cat gag ccc cga ctc aag tcc ctc agc 720 Ala Val Phe Arg Leu Pro Thr His Glu Pro Arg Leu Lys Ser Leu Ser 225 230 235 240 aca tgt ggt tca cat gtg tgt gta atc ctt gcc ttc tat aca cca gcc 768 Thr Cys Gly Ser His Val Cys Val Ile Leu Ala Phe Tyr Thr Pro Ala 245 250 255 ctc ttt tcc ttt atg act cat tgc ttt ggc cga aat gtg ccc cgc tat 816 Leu Phe Ser Phe Met Thr His Cys Phe Gly Arg Asn Val Pro Arg Tyr 260 265 270 atc cat ata ctc cta gcc aat ctc tat gtt gtg gtg cca cca atg ctc 864 Ile His Ile Leu Leu Ala Asn Leu Tyr Val Val Val Pro Pro Met Leu 275 280 285 aat cct gtc ata tat gga gtc aga acc aag cag atc tat aaa tgt gta 912 Asn Pro Val Ile Tyr Gly Val Arg Thr Lys Gln Ile Tyr Lys Cys Val 290 295 300 aag aaa ata tta ttg cag gaa caa gga atg gaa aag gaa gag tac cta 960 Lys Lys Ile Leu Leu Gln Glu Gln Gly Met Glu Lys Glu Glu Tyr Leu 305 310 315 320 ata cat acg agg ttc tga 978 Ile His Thr Arg Phe 325 <210> 220 < 211> 325 <212> PRT <213> Homo sapiens <400> 220 Met Phe Leu Pro Asn Asp Thr Gln Phe His Pro Ser Ser Phe Leu Leu 1 5 10 15 Leu Gly Ile Pro Gly Leu Glu Thr Leu His Ile Trp Ile Gly Phe Pro 20 25 30 Phe Cys Ala Val Tyr Met Ile Ala Leu Ile Gly Asn Phe Thr Ile Leu 35 40 45 Leu Val Ile Lys Thr Asp Ser Ser Leu His Gln Pro Met Phe Tyr Phe 50 55 60 Leu Ala Met Leu Ala Thr Thr Asp Val Gly Leu Ser Thr Ala Thr Ile 65 70 75 80 Pro Lys Met Leu Gly Ile Phe Trp Ile Asn Leu Arg Gly Ile Ile Phe 85 90 95 Glu Ala Cys Leu Thr Gln Met Phe Phe Ile His Asn Phe Thr Leu Met 100 105 110 Glu Ser Ala Val Leu Val Ala Met Ala Tyr Asp Ser Tyr Val Ala Ile 115 120 125 Cys Asn Pro Leu Gln Tyr Ser Ala Ile Leu Thr Asn Lys Val Val Ser 130 135 140 Val Ile Gly Leu Gly Val Phe Val Arg Ala Leu Ile Phe Val Ile Pro 145 150 155 160 Ser Ile Leu Leu Ile Leu Arg Leu Pro Phe Cys Gly Asn His Val Ile 165 170 175 Pro His Thr Tyr Cys Glu His Met Gly Leu Ala His Leu Ser Cys Ala 180 185 190 Ser Ile Lys Ile Asn Ile Ile Tyr Gly Leu Cys Ala Ile Cys Asn Leu 195 200 205 Val Phe Asp Ile Thr Val Ile Ala Leu Ser Tyr Val His Ile Leu Cys 210 215 220 Ala Val Phe Arg Leu Pro Thr His Glu Pro Arg Leu Lys Ser Leu Ser 225 230 235 240 Thr Cys Gly Ser His Val Cys Val Ile Leu Ala Phe Tyr Thr Pro Ala 245 250 255 Leu Phe Ser Phe Met Thr His Cys Phe Gly Arg Asn Val Pro Arg Tyr 260 265 270 Ile His Ile Leu Leu Ala Asn Leu Tyr Val Val Val Pro Pro Met Leu 275 280 285 Asn Pro Val Ile Tyr Gly Val Arg Thr Lys Gln Ile Tyr Lys Cys Val 290 295 300 Lys Lys Ile Leu Leu Gln Glu Gln Gly Met Glu Lys Glu Glu Tyr Leu 305 310 315 320 Ile His Thr Arg Phe 325 <210> 221 <211> 777 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(777) <400> 221 atg gac atc tgc ggc acc tcc tcc ttt gtg cct ctc atg cta gac aat 48 Met Asp Ile Cys Gly Thr Ser Ser Phe Val Pro Leu Met Leu Asp Asn 1 5 10 15 ttc ctg gaa acc cag agg acc att tcc ttc cct ggc tgt gcc ctg cag 96 Phe Leu Glu Thr Gln Arg Thr Ile Ser Phe Pro Gly Cys Ala Leu Gln 20 25 30 atg tac ctg acc ctg gcg ctg gga tca acg gag tgc ctg ctg ctg gct 144 Met Tyr Leu Thr Leu Ala Leu Gly Ser Thr Glu Cys Leu Leu Leu Ala 35 40 45 gtg atg gca tat gac cgt tat gtg gct atc tgc cag ccg ctt agg tac 192 Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Gln Pro Leu Arg Tyr 50 55 60 cca gag ctc atg agt ggg cag acc tgc atg cag atg gca gcg ctg agc 240 Pro Glu Leu Met Ser Gly Gln Thr Cys Met Gln Met Ala Ala Leu Ser 65 70 75 80 tgg ggg aca ggc ttt gcc aac tca ctg cta cag tcc atc ctt gtc tgg 288 Trp Gly Thr Gly Phe Ala Asn Ser Leu Leu Gln Ser Ile Leu Val Trp 85 90 95 cac ctc ccc ttc tgt ggc cac gtc atc aac tac ttc tat gag atc ttg 336 His Leu Pro Phe Cys Gly His Val Ile Asn Tyr Phe Tyr Glu Ile Leu 100 105 110 gca gtg cta aaa ctg gcc tgt ggg gac atc tcc ctc aat gcg ctg gca 384 Ala Val Leu Lys Leu Ala Cys Gly Asp Ile Ser Leu Asn Ala Leu Ala 115 120 125 tta atg gtg gcc aca gcc gtc ctg aca ctg gcc ccc ctc ttg ctc atc 432 Leu Met Val Ala Thr Ala Val Leu Thr Leu Ala Pro Leu Leu Leu Ile 130 135 140 tgc ctg tct tac ctt ttc atc ctg tct gcc atc ctt agg gta ccc tct 480 Cys Leu Ser Tyr Leu Phe Ile Leu Ser Ala Ile Leu Arg Val Pro Ser 145 150 155 160 gct gca ggc cgg tgc aaa gcc ttc tcc acc tgc tca gcc cac cgc aca 528 Ala Ala Gly Arg Cys Lys Ala Phe Ser Thr Cys Ser Ala His Arg Thr 165 170 175 gtg gtg gtg gtt ttt tat ggg aca atc tcc ttc atg tac ttc aaa ccc 576 Val Val Val Val Phe Tyr Gly Thr Ile Ser Phe Met Tyr Phe Lys Pro 180 185 190 aag gcc aag gat ccc aac gtg gat aag act gtc gca ttg ttc tac ggg 624 Lys Ala Lys Asp Pro Asn Val Asp Lys Thr Val Ala Leu Phe Tyr Gly 195 200 205 gtt gtg acg ccc tcg ctg aac ccc atc att tac agc ctg agg aat gca 672 Val Val Thr Pro Ser Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Ala 210 215 220 gag gtg aaa gct gcc gtc cta act ctg ctg aga gga ggt ttg ctc tcc 720 Glu Val Lys Ala Ala Val Leu Thr Leu Leu Arg Gly Gly Leu Leu Ser 225 230 235 240 agg aaa gca tcc cac tgc tac tgc tgc cct ctg ccc ctg tca gct ggc 768 Arg Lys Ala Ser His Cys Tyr Cys Cys Pro Leu Pro Leu Ser Ala Gly 245 250 255 ata ggc tag 777 Ile Gly <210> 222 <211> 258 <212> PRT <213> Homo sapiens <400> 222 Met Asp Ile Cys Gly Thr Ser Ser Phe Val Pro Leu Met Leu Asp Asn 1 5 10 15 Phe Leu Glu Thr Gln Arg Thr Ile Ser Phe Pro Gly Cys Ala Leu Gln 20 25 30 Met Tyr Leu Thr Leu Ala Leu Gly Ser Thr Glu Cys Leu Leu Leu Ala 35 40 45 Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Gln Pro Leu Arg Tyr 50 55 60 Pro Glu Leu Met Ser Gly Gln Thr Cys Met Gln Met Ala Ala Leu Ser 65 70 75 80 Trp Gly Thr Gly Phe Ala Asn Ser Leu Leu Gln Ser Ile Leu Val Trp 85 90 95 His Leu Pro Phe Cys Gly His Val Ile Asn Tyr Phe Tyr Glu Ile Leu 100 105 110 Ala Val Leu Lys Leu Ala Cys Gly Asp Ile Ser Leu Asn Ala Leu Ala 115 120 125 Leu Met Val Ala Thr Ala Val Leu Thr Leu Ala Pro Leu Leu Leu Ile 130 135 140 Cys Leu Ser Tyr Leu Phe Ile Leu Ser Ala Ile Leu Arg Val Pro Ser 145 150 155 160 Ala Ala Gly Arg Cys Lys Ala Phe Ser Thr Cys Ser Ala His Arg Thr 165 170 175 Val Val Val Val Phe Tyr Gly Thr Ile Ser Phe Met Tyr Phe Lys Pro 180 185 190 Lys Ala Lys Asp Pro Asn Val Asp Lys Thr Val Ala Leu Phe Tyr Gly 195 200 205 Val Val Thr Pro Ser Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Ala 210 215 220 Glu Val Lys Ala Ala Val Leu Thr Leu Leu Arg Gly Gly Leu Leu Ser 225 230 235 240 Arg Lys Ala Ser His Cys Tyr Cys Cys Pro Leu Pro Leu Ser Ala Gly 245 250 255 Ile Gly <210> 223 <211> 672 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(672) <400> 223 atg gcc aat gtc acc ttg gtg aca gga ttt ctt ctt atg ggg ttt tct 48 Met Ala Asn Val Thr Leu Val Thr Gly Phe Leu Leu Met Gly Phe Ser 1 5 10 15 aat atc cag aag ctg cgg att tta tat ggt gtg ctc ttc cta ctg att 96 Asn Ile Gln Lys Leu Arg Ile Leu Tyr Gly Val Leu Phe Leu Leu Ile 20 25 30 tac ctg gca gcc cta atg agt aac ctt ctc atc att act ctc att acc 144 Tyr Leu Ala Ala Leu Met Ser Asn Leu Leu Ile Ile Thr Leu Ile Thr 35 40 45 ctg gac gta aag ctc caa aca ccc atg tac ttc ttc ctg aag aac tta 192 Leu Asp Val Lys Leu Gln Thr Pro Met Tyr Phe Phe Leu Lys Asn Leu 50 55 60 tcc ttt ttg gat gtc ttc ctg gtg tct gtt cca atc cca aaa ttc att 240 S er Phe Leu Asp Val Phe Leu Val Ser Val Pro Ile Pro Lys Phe Ile 65 70 75 80 gtc aac aac cta acc cac aac aat tcc att tcc att cta gga tgt gcc 288 Val Asn Asn Leu Thr His Asn Asn Ser Ile Ser Ile Leu Gly Cys Ala 85 90 95 ttc cag cta ctt tta atg act tcc ttc tca gca gga gag ata ttt atc 336 Phe Gln Leu Leu Leu Met Thr Ser Phe Ser Ala Gly Glu Ile Phe Ile 100 105 110 ctc act gcc atg tcc tat gac cgc tat gta gcc atc tgc tgt ccc ctg 384 Leu Thr Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Cys Pro Leu 115 120 125 aac tac gag gta atc atg aat act gga gtc tgt gtg tta atg gca agt 432 Asn Tyr Glu Val Ile Met Asn Thr Gly Val Cys Val Leu Met Ala Ser 130 135 140 gtt tcc tgg gcc att gga ggg ctc ttt ggt act gcg tac aca gct ggc 480 Val Ser Trp Ala Ile Gly Gly Leu Phe Gly Thr Ala Tyr Thr Ala Gly 145 150 155 160 aca ttt tcc atg cct ttc tgt ggc tcc agt gtg att cca cag ttt ttc 528 Thr Phe Ser Met Pro Phe Cys Gly Ser Ser Val Ile Pro Gln Phe Phe 165 170 175 tgt gat gtt cct tca tta cta agg att tcc tgt tct gaa aca cta atg 576 Cys Asp Val Pro Ser Leu Leu Arg Ile Ser Cys Ser Glu Thr Leu Met 180 185 190 gta att tat gca ggt att gga gtt ggt gca tgt tta agc att tct tgt 624 Val Ile Tyr Ala Gly Ile Gly Val Gly Ala Cys Leu Ser Ile Ser Cys 195 200 205 ttc atc tgt att gtg atc tct tac att ata tct tct cca ctg tac tga 672 Phe Ile Cys Ile Val Ile Ser Tyr Ile Ile Ser Ser Pro Leu Tyr 210 215 220 <210> 224 <211> 223 <212> PRT <213> Homo sapiens <400> 224 Met Ala Asn Val Thr Leu Val Thr Gly Phe Leu Leu Met Gly Phe Ser 1 5 10 15 Asn Ile Gln Lys Leu Arg Ile Leu Tyr Gly Val Leu Phe Leu Leu Ile 20 25 30 Tyr Leu Ala Ala Leu Met Ser Asn Leu Leu Ile Ile Thr Leu Ile Thr 35 40 45 Leu Asp Val Lys Leu Gln Thr Pro Met Tyr Phe Phe Leu Lys Asn Leu 50 55 60 Ser Phe Leu Asp Val Phe Leu Val Ser Val Pro Ile Pro Lys Phe Ile 65 70 75 80 Val Asn Asn Leu Thr His Asn Asn Ser Ile Ser Ile Leu Gly Cys Ala 85 90 95 Phe Gln Leu Leu Leu Met Thr Ser Phe Ser Ala Gly Glu Ile Phe Ile 100 105 110 Leu Thr Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Cys Pro Leu 115 120 125 A sn Tyr Glu Val Ile Met Asn Thr Gly Val Cys Val Leu Met Ala Ser 130 135 140 Val Ser Trp Ala Ile Gly Gly Leu Phe Gly Thr Ala Tyr Thr Ala Gly 145 150 155 160 Thr Phe Ser Met Pro Phe Cys Gly Ser Ser Val Ile Pro Gln Phe Phe 165 170 175 Cys Asp Val Pro Ser Leu Leu Arg Ile Ser Cys Ser Glu Thr Leu Met 180 185 190 Val Ile Tyr Ala Gly Ile Gly Val Gly Ala Cys Leu Ser Ile Ser Cys 195 200 205 Phe Ile Cys Ile Val Ile Ser Tyr Ile Ile Ser Ser Pro Leu Tyr 210 215 220 <210> 225 <211> 933 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(933) <400> 225 atg gac cca cag aac tat tcc ttg gtg tca gaa ttt gtg ttg cat gga 48 Met Asp Pro Gln Asn Tyr Ser Leu Val Ser Glu Phe Val Leu His Gly 1 5 10 15 ctc tgc act tca cga cat ctt caa aat ttt ttc ttt ata ttt ttc ttt 96 Leu Cys Thr Ser Arg His Leu Gln Asn Phe Phe Phe Ile Phe Phe Phe 20 25 30 ggg gtc tat gtg gcc att atg ctg ggt aac ctt ctc att ttg gtc act 144 Gly Val Tyr Val Ala Ile Met Leu Gly Asn Leu Leu Ile Leu Val Thr 35 40 45 gta att tct gat ccc tgc ctg cac tcc tcc cct atg tac ttc ctg ctg 192 Val Ile Ser Asp Pro Cys Leu His Ser Ser Pro Met Tyr Phe Leu Leu 50 55 60 ggg aac cta gct ttc ctg gac atg tgg ctg gcc tca ttt gcc act ccc 240 Gly Asn Leu Ala Phe Leu Asp Met Trp Leu Ala Ser Phe Ala Thr Pro 65 70 75 80 aag atg atc agg gat ttc ctt agt gat caa aaa ctc atc tcc ttt gga 288 Lys Met Ile Arg Asp Phe Leu Ser Asp Gln Lys Leu Ile Ser Phe Gly 85 90 95 gga tgt atg gct caa atc ttc ttc ttg cac ttt act ggt ggg gct gag 336 Gly Cys Met Ala Gln Ile Phe Phe Leu His Phe Thr Gly Gly Ala Glu 100 105 110 a tg gtg ctc ctg gtt tcc atg gcc tat gac aga tat gtg gcc ata tgc 384 Met Val Leu Leu Val Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys 115 120 125 aaa ccc ttg cat tac atg act ttg atg agt tgg cag act tgc atc agg 432 Lys Pro Leu His Tyr Met Thr Leu Met Ser Trp Gln Thr Cys Ile Arg 130 135 140 ctg gtg ctg gct tca tgg gtc gtt gga ttt gtg cac tcc atc agt caa 480 Leu Val Leu Ala Ser Trp Val Val Gly Phe Val His Ser Ile Ser Gln 145 150 155 160 gtg gct ttc act gta aat ttg cct tac tgt ggc ccc aat gag gta gac 528 Val Ala Phe Thr Val Asn Leu Pro Tyr Cys Gly Pro Asn Glu Val Asp 165 170 175 agc ttc ttc tgt gac ctc cct ctg gtg atc aaa ctt gcc tgc atg gac 576 Ser Phe Phe Cys Asp Leu Pro Leu Val Ile Lys Leu Ala Cys Met Asp 180 185 190 acc tat gtc ttg ggt ata att atg atc tca gac agt ggg ttg ctt tcc 624 Thr Tyr Val Leu Gly Ile Ile Met Ile Ser Asp Ser Gly Leu Leu Ser 195 200 205 ttg agc tgt ttt ctg ctc ctc ctg atc tcc tac acc gtg atc ctc ctc 672 Leu Ser Cys Phe Leu Leu Leu Leu Ile Ser Tyr Thr Val Ile Leu Leu 210 215 220 gct atc aga cag cgt gct gcc ggt agc aca tcc aaa gca ctc tcc act 720 Ala Ile Arg Gln Arg Ala Ala Gly Ser Thr Ser Lys Ala Leu Ser Thr 225 230 235 240 tgc tct gca cat atc atg gta gtg acg ctg ttc ttt ggc cct tgc att 768 Cys Ser Ala His Ile Met Val Val Thr Leu Phe Phe Gly Pro Cys Ile 245 250 255 ttt gtt tat gtg cgg cct ttc agt agg ttc tct gtg gac aag ctg ctg 816 Phe Val Tyr Val Arg Pro Phe Ser Arg Phe Ser Val Asp Lys Leu Leu 260 265 270 tct gtg ttt tat acc att ttt act cca ctc ctg aac ccc att atc tac 864 Ser Val Phe Tyr Thr Ile Phe Thr Pro Leu Leu Asn Pro Ile Ile Tyr 275 280 285 aca ttg aga aat gag gag atg aaa gca gct atg aag aaa ctg caa aac 912 Thr Leu Arg Asn Glu Glu Met Lys Ala Ala Met Lys Lys Leu Gln Asn 290 295 300 cga cgg gtg act ttt caa tga 933 Arg Arg Val Thr Phe Gln 305 310 <210> 226 <211> 310 <212> PRT <213> Homo sapiens <400> 226 Met Asp Pro Gln Asn Tyr Ser Leu Val Ser Glu Phe Val Leu His Gly 1 5 10 15 Leu Cys Thr Ser Arg His Leu Gln Asn Phe Phe Phe Ile Phe Phe Phe 20 25 30 Gly Val Tyr Val Ala Ile Met Leu Gly Asn Leu Leu Ile Leu Val Thr 35 40 45 Val Ile Ser Asp Pro Cys Leu His Ser Ser Pro Met Tyr Phe Leu Leu 50 55 60 Gly Asn Leu Ala Phe Leu Asp Met Trp Leu Ala Ser Phe Ala Thr Pro 65 70 75 80 Lys Met Ile Arg Asp Phe Leu Ser Asp Gln Lys Leu Ile Ser Phe Gly 85 90 95 Gly Cys Met Ala Gln Ile Phe Phe Leu His Phe Thr Gly Gly Ala Glu 100 105 110 Met Val Leu Leu Val Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys 115 120 125 Lys Pro Leu His Tyr Met Thr Leu Met Ser Trp Gln Thr Cys Ile Arg 130 135 140 Leu Val Leu Ala Ser Trp Val Val Gly Phe Val His Ser Ile Ser Gln 145 150 155 160 Val Ala Phe Thr Val Asn Leu Pro Tyr Cys Gly Pro Asn Glu Val Asp 165 170 175 Ser Phe Phe Cys Asp Leu Pro Leu Val Ile Lys Leu Ala Cys Met Asp 180 185 190 Thr Tyr Val Leu Gly Ile Ile Met Ile Ser Asp Ser Gly Leu Leu Ser 195 200 205 Leu Ser Cys Phe Leu Leu Leu Leu Ile Ser Tyr Thr Val Ile Leu Leu 210 215 220 Ala Ile Arg Gln Arg Ala Ala Gly Ser Thr Ser Lys Ala Leu Ser Thr 225 230 235 240 Cys Ser Ala His Ile Met Val Val Thr Leu Phe Phe Gly Pro Cys Ile 245 250 255 Phe Val Tyr Val Arg Pro Phe Ser Arg Phe Ser Val Asp Lys Leu Leu 260 265 270 Ser Val Phe Tyr Thr Ile Phe Thr Pro Leu Leu Asn Pro Ile Ile Tyr 275 280 285 Thr Leu Arg Asn Glu Glu Met Lys Ala Ala Met Lys Lys Leu Gln Asn 290 295 300 Arg Arg Val Thr Phe Gln 305 310 <210> 227 <211> 939 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(939) <400> 227 atg gat ctt aaa aat gga tct cta gtg acc gag ttt att tta cta gga 48 Met Asp Leu Lys Asn Gly Ser Leu Val Thr Glu Phe Ile Leu Leu Gly 1 5 10 15 ttt ttt gga cga tgg gaa ctt caa att ttc ttc ttt gtg aca ttt tcc 96 Phe Phe Gly Arg Trp Glu Leu Gln Ile Phe Phe Phe Val Thr Phe Ser 20 25 30 ctg atc tac ggt gct act gtg atg gga aac att ctc att atg gtc aca 144 Leu Ile Tyr Gly Ala Thr Val Met Gly Asn Ile Leu Ile Met Val Thr 35 40 45 gtg aca tgt agg tca acc ctt cat tct ccc ttg tac ttt ctc ctt gga 192 Val Thr Cys Arg Ser Thr Leu His Ser Pro Leu Tyr Phe Leu Leu Gly 50 55 60 aat ctc tct ttt ttg gac atg tgt ctc tcc act gcc aca aca ccc aag 240 Asn Leu Ser Phe Leu Asp Met Cys Leu Ser Thr Ala Thr Thr Pro Lys 65 70 75 80 atg atc ata gat ttg ctc act gac cac aag acc atc tct gtg tgg ggc 288 Met Ile Ile Asp Leu Leu Thr Asp His Lys Thr Ile Ser Val Trp Gly 85 90 95 tgc gtg acc cag atg ttc ttc atg cac ttc ttt ggg ggt gct gag atg 336 Cys Val Thr Gln Met Phe Phe Met His Phe Phe Gly Gly Ala Glu Met 100 105 110 act ctt ctg ata atc atg gcc ttt gac agg tat gta gcc ata tgt aaa 384 Thr Leu Leu Ile Ile Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Lys 115 120 125 ccc ctg cac tat agg aca atc atg agc cac aag ctg cta aag ggg ttt 432 Pro Leu His Tyr Arg Thr Ile Met Ser His Lys Leu Leu Lys Gly Phe 130 135 140 gcg ata ctt tca tgg ata att ggt ttt tta cac tcc ata agc cag ata 480 Ala Ile Leu Ser Trp Ile Ile Gly Phe Leu His Ser Ile Ser Gln Ile 145 150 155 160 gtt tta aca atg aac ttg cct ttc tgt ggc cac aat gtc ata aac aac 528 Val Leu Thr Met Asn Leu Pro Phe Cys Gly His Asn Val Ile Asn Asn 165 170 175 ata ttt tgt gat ctt ccc ctt gtg atc aag ctt gct tgc att gaa aca 576 Ile Phe Cys Asp Leu Pro Leu Val Ile Lys Leu Ala Cys Ile Glu Thr 180 185 190 tac acc ctg gaa tta ttt gtc att gct gac agc ggg ctg ctc tct ttc 624 Tyr Thr Leu Glu Leu Phe Val Ile Ala Asp Ser Gly Leu Leu Ser Phe 195 200 205 acc tgt ttc atc ctc ttg ctt gtt tct tac att gtc atc ctg gtc agt 672 Thr Cys Phe Ile Leu Leu Leu Val Ser Tyr Ile Val Ile Leu Val Ser 210 215 220 gta cca aaa aaa tca tca cat ggg ctc tcc aag gcg ctg tcc aca ttg 720 Val Pro Lys Lys Ser Ser His Gly Leu Ser Lys Ala Leu Ser Thr Leu 225 230 235 240 tct gcc cac atc att gtg gtc act ctg ttc ttt gga cct tgt att ttt 768 Ser Ala His Ile Ile Val Val Thr Leu Phe Phe Gly Pro Cys Ile Phe 245 250 255 atc tat gtt tgg cca ttc agt agt ttg gca agc aat aaa act ctt gcc 816 Ile Tyr Val Trp Pro Phe Ser Ser Leu Ala Ser Asn Lys Thr Leu Ala 260 265 270 gta ttt tat aca gtt atc aca ccc tta ctg aat ccg agt att tat acc 864 Val Phe Tyr Thr Val Ile Thr Pro Leu Leu Asn Pro Ser Ile Tyr Thr 275 280 285 ctg aga aat aag aaa atg caa gag gcc ata aga aaa tta cgg ttc caa 912 Leu Arg Asn Lys Lys Met Gln Glu Ala Ile Arg Lys Leu Arg Phe Gln 290 295 300 tat gtt agt tct gca cag aat ttc tag 939 Tyr Val Ser Ser Ala Gln Asn Phe 305 310 <210> 228 <211> 312 <212> PRT <213> Homo sapiens <400> 228 Met Asp Leu Lys Asn Gly Ser Leu Val Thr Glu Phe Ile Leu Leu Gly 1 5 10 15 Phe Phe Gly Arg Trp Glu Leu Gln Ile Phe Phe Phe Val Thr Phe Ser 20 25 30 Leu Ile Tyr Gly Ala Thr Val Met Gly Asn Ile Leu Ile Met Val Thr 35 40 45 Val Thr Cys Arg Ser Thr Leu His Ser Pro Leu Tyr Phe Leu Leu Gly 50 55 60 Asn Leu Ser Phe Leu Asp Met Cys Leu Ser Thr Ala Thr Thr Pro Lys 65 70 75 80 Met Ile Ile Asp Leu Leu Thr Asp His Lys Thr Ile Ser Val Trp Gly 85 90 95 Cys Val Thr Gln Met Phe Phe Met His Phe Phe Gly Gly Ala Glu Met 100 105 110 Thr Leu Leu Ile Ile Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Lys 115 120 125 Pro Leu His Tyr Arg Thr Ile Met Ser His Lys Leu Leu Lys Gly Phe 130 135 140 Ala Ile Leu Ser Trp Ile Ile Gly Phe Leu His Ser Ile Ser Gln Ile 145 150 155 160 Val Leu Thr Met Asn Leu Pro Phe Cys Gly His Asn Val Ile Asn Asn 165 170 175 Ile Phe Cys Asp Leu Pro Leu Val Ile Lys Leu Ala Cys Ile Glu Thr 180 185 190 Tyr Thr Leu Glu Leu Phe Val Ile Ala Asp Ser Gly Leu Leu Ser Phe 195 200 205 Thr Cys Phe Ile Leu Leu Leu Val Ser Tyr Ile Val Ile Leu Val Ser 210 215 220 Val Pro Lys Lys Ser Ser His Gly Leu Ser Lys Ala Leu Ser Thr Leu 225 230 235 240 Ser Ala His Ile Ile Val Val Thr Leu Phe Phe Gly Pro Cys Ile Phe 245 250 255 Ile Tyr Val Trp Pro Phe Ser Ser Leu Ala Ser Asn Lys Thr Leu Ala 260 265 270 Val Phe Tyr Thr Val Ile Thr Pro Leu Leu Asn Pro Ser Ile Tyr Thr 275 280 285 Leu Arg Asn Lys Lys Met Gln Glu Ala Ile Arg Lys Leu Arg Phe Gln 290 295 300 Tyr Val Ser Ser Ala Gln Asn Phe 305 310 <210> 229 <211> 840 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(840) <400> 229 atg tat ttc ttc ctt gcc aat ctg tcc ttg gta gac ctc tgc ctt ccc 48 Met Tyr Phe Phe Leu Ala Asn Leu Ser Leu Val Asp Leu Cys Leu Pro 1 5 10 15 tca gcc aca gtc ccc aag atg cta ctg aac atc caa acc caa acc caa 96 Ser Ala Thr Val Pro Lys Met Leu Leu Asn Ile Gln Thr Gln Thr Gln 20 25 30 acc atc tcc tat ccc ggc tgc ctg gct cag atg tat ttc tgt atg atg 144 Thr Ile Ser Tyr Pro Gly Cys Leu Ala Gln Met Tyr Phe Cys Met Met 35 40 45 ttt gcc aat atg gac aat ttt ctt ctc aca gtg atg gca tat gac cgt 192 Phe Ala Asn Met Asp Asn Phe Leu Leu Thr Val Met Ala Tyr Asp Arg 50 55 60 tac gtg gcc atc tgt cac cct tta cat tac tcc acc att atg gcc ctg 240 Tyr Val Ala Ile Cys His Pro Leu His Tyr Ser Thr Ile Met Ala Leu 65 70 75 80 cgc ctc tgt gcc tct ctg gta gct gca cct tgg gtc att gcc att ttg 288 Arg Leu Cys Ala Ser Leu Val Ala Ala Pro Trp Val Ile Ala Ile Leu 85 90 95 aac cct ctc ttg cac act ctt atg atg gcc cat ctg cac ttc tgc tct 336 Asn Pro Leu Leu His Thr Leu Met Met Ala His Leu His Phe Cys Ser 100 105 110 gat aat gtt atc cac cat ttc ttc tgt gat atc aac tct ctc ctc cct 384 Asp Asn Val Ile His His Phe Phe Cys Asp Ile Asn Ser Leu Leu Pro 115 120 125 ctg tcc tgt tcc gac acc agt ctt aat cag ttg agt gtt ctg gct acg 432 Leu Ser Cys Ser Asp Thr Ser Leu Asn Gln Leu Ser Val Leu Ala Thr 130 135 140 gtg ggg ctg atc ttt gtg gta cct tca gtg tgt atc ctg gta tcc tat 480 Val Gly Leu Ile Phe Val Val Pro Ser Val Cys Ile Leu Val Ser Tyr 145 150 155 160 atc ctc att gtt tct gct gtg atg aaa gtc cct tct gcc caa gga aaa 528 Ile Leu Ile Val Ser Ala Val Met Lys Val Pro Ser Ala Gln Gly Lys 165 170 175 ctc aag gct ttc tct acc tgt gga tct cac ctt gcc ttg gtc att ctt 576 Leu Lys Ala Phe Ser Thr Cys Gly Ser His Leu Ala Leu Val Ile Leu 180 185 190 ttc tat gga gca atc aca ggg gtc tat atg agc ccc tta tcc aat cac 624 Phe Tyr Gly Ala Ile Thr Gly Val Tyr Met Ser Pro Leu Ser Asn His 195 200 205 tct act gaa aaa gac tca gcc gca tca gtc att ttt atg gtt gta gca 672 Ser Thr Glu Lys Asp Ser Ala Ala Ser Val Ile Phe Met Val Val Ala 210 215 220 cct gtg ttg aat cca ttc att tac agt tta aga aac aat gaa ctg aag 720 Pro Val Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn Asn Glu Leu Lys 225 230 235 240 ggg act tta aaa aag acc cta agc cga ccg ggc gcg gtg gct cac gcc 768 Gly Thr Leu Lys Lys Thr Leu Ser Arg Pro Gly Ala Val Ala His Ala 245 250 255 tgt aat ccc agc act ttg gga ggc cga ggc ggg tgg atc atg agg tca 816 Cys Asn Pro Ser Thr Leu Gly Gly Arg Gly Gly Trp Ile Met Arg Ser 260 265 270 gga gat cga gac cat cct ggc taa 840 Gly Asp Arg Asp His Pro Gly 275 280 <210> 230 <211> 279 <212> PRT <213> Homo sapiens <400> 230 Met Tyr Phe Phe Leu Ala Asn Leu Ser Leu Val Asp Leu Cys Leu Pro 1 5 10 15 Ser Ala Thr Val Pro Lys Met Leu Leu Asn Ile Gln Thr Gln Thr Gln 20 25 30 Thr Ile Ser Tyr Pro Gly Cys Leu Ala Gln Met Tyr Phe Cys Met Met 35 40 45 Phe Ala Asn Met Asp Asn Phe Leu Leu Thr Val Met Ala Tyr Asp Arg 50 55 60 Tyr Val Ala Ile Cys His Pro Leu His Tyr Ser Thr Ile Met Ala Leu 65 70 75 80 Arg Leu Cys Ala Ser Leu Val Ala Ala Pro Trp Val Ile Ala Ile Leu 85 90 95 Asn Pro Leu Leu His Thr Leu Met Met Ala His Leu His Phe Cys Ser 100 105 110 Asp Asn Val Ile His His Phe Phe Cys Asp Ile Asn Ser Leu Leu Pro 115 120 125 Leu Ser Cys Ser Asp Thr Ser Leu Asn Gln Leu Ser Val Leu Ala Thr 130 135 140 Val Gly Leu Ile Phe Val Val Pro Ser Val Cys Ile Leu Val Ser Tyr 145 150 155 160 Ile Leu Ile Val Ser Ala Val Met Lys Val Pro Ser Ala Gln Gly Lys 165 170 175 Leu Lys Ala Phe Ser Thr Cys Gly Ser His Leu Ala Leu Val Ile Leu 180 185 190 Phe Tyr Gly Ala Ile Thr Gly Val Tyr Met Ser Pro Leu Ser Asn His 195 200 205 Ser Thr Glu Lys Asp Ser Ala Ala Ser Val Ile Phe Met Val Val Ala 210 215 220 Pro Val Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn Asn Glu Leu Lys 225 230 235 240 Gly Thr Leu Lys Lys Thr Leu Ser Arg Pro Gly Ala Val Ala His Ala 245 250 255 Cys Asn Pro Ser Thr Leu Gly Gly Arg Gly Gly Trp Ile Met Arg Ser 260 265 270 Gly Asp Arg Asp His Pro Gly 275 <210> 231 <211> 951 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(951) <400> 231 atg atc tgt gaa aat cac acc aga gtc act gaa ttt att ctt ctt ggt 48 Met Ile Cys Glu Asn His Thr Arg Val Thr Glu Phe Ile Leu Leu Gly 1 5 10 15 ttt aca aac aac ccc gag atg caa gtt tcc ctc ttt att ttt ttc ctg 96 Phe Thr Asn Asn Pro Glu Met Gln Val Ser Leu Phe Ile Phe Phe Leu 20 25 30 gcc att tat aca gtc act ttg ttg ggc aac ttt ctt att gtc aca gtt 144 Ala Ile Tyr Thr Val Thr Leu Leu Gly Asn Phe Leu Ile Val Thr Val 35 40 45 acc agt gtg gat ctc gca ctt caa aca ccc atg tac ttc ttt ctt caa 192 Thr Ser Val Asp Leu Ala Leu Gln Thr Pro Met Tyr Phe Phe Leu Gln 50 55 60 aat ctg tca ctt ctt gaa gta tgt ttc acc ttg gtt atg gtg cca aaa 240 Asn Leu Ser Leu Leu Glu Val Cys Phe Thr Leu Val Met Val Pro Lys 65 70 75 80 atg ctt gta gat cta gtg tcc cca agg aaa att atc tct ttt gtg ggc 288 Met Leu Val Asp Leu Val Ser Pro Arg Lys Ile Ile Ser Phe Val Gly 85 90 95 tgt ggt acc cag atg tac ttc ttc ttc ttc ttt ggc agt tct gaa tgt 336 Cys Gly Thr Gln Met Tyr Phe Phe Phe Phe Phe Gly Ser Ser Glu Cys 100 105 110 ttc ctt ctc tcc atg atg gct tat gat cgc ttt gtg gcc atc tgt aac 384 Phe Leu Leu Ser Met Met Ala Tyr Asp Arg Phe Val Ala Ile Cys Asn 115 120 125 cct ctc cat tat tca gtc ata atg aac agg tcc cta tgc ttg tgg atg 432 Pro Leu His Tyr Ser Val Ile Met Asn Arg Ser Leu Cys Leu Trp Met 130 135 140 gcc ata ggc tct tgg atg tcc ggt gtt cct gtg tct atg cta cag aca 480 Ala Ile Gly Ser Trp Met Ser Gly Val Pro Val Ser Met Leu Gln Thr 145 150 155 160 gct tgg atg atg gcc ctt cct ttc tgt gga cca aat gcc gtg gac cac 528 Ala Trp Met Met Ala Leu Pro Phe Cys Gly Pro Asn Ala Val Asp His 165 170 175 ttt ttc tgt gat ggt ccc cca gtg tta aaa cta gtc aca gtg gat aca 576 Phe Phe Cys Asp Gly Pro Pro Val Leu Lys Leu Val Thr Val Asp Thr 180 185 190 acc atg tat gaa atg caa gca ctt gcc tcc aca ctc ctg ttt atc atg 624 Thr Met Tyr Glu Met Gln Ala Leu Ala Ser Thr Leu Leu Phe Ile Met 195 200 205 ttt ccc ttt tgt ctc att ttg gtt tcc tac acc cgc att atc ata aca 672 Phe Pro Phe Cys Leu Ile Leu Val Ser Tyr Thr Arg Ile Ile Ile Thr 210 215 220 att ctg agg atg tcc tct gcc act ggc cgc cag aag gca ttt tct act 720 Ile Leu Arg Met Ser Ser Ala Thr Gly Arg Gln Lys Ala Phe Ser Thr 225 230 235 240 tgt tcc tca cac ctc att gtg gtg tcc ctc ttc tac gga aca gcc agt 768 Cys Ser Ser His Leu Ile Val Val Ser Leu Phe Tyr Gly Thr Ala Ser 245 250 255 ctg acc tac ctg cgg ccc aaa tca aac cag tcc cct gag agc aag aag 816 Leu Thr Tyr Leu Arg Pro Lys Ser Asn Gln Ser Pro Glu Ser Lys Lys 260 265 270 cta gtg tca ttg tcc tac act gtc atc aca cct atg cta aac ccc atc 864 Leu Val Ser Leu Ser Tyr Thr Val Ile Thr Pro Met Leu Asn Pro Ile 275 280 285 atc tac ggc ctg agg aac aat gaa gtg aaa ggg gct gtc aag agg aca 912 Ile Tyr Gly Leu Arg Asn Asn Glu Val Lys Gly Ala Val Lys Arg Thr 290 295 300 atc act caa aaa gtc tta cag aag tta gat gtg ttt tga 951 Ile Thr Gln Lys Val Leu Gln Lys Leu Asp Val Phe 305 310 315 <210> 232 <211> 316 <212> PRT <213> Homo sapiens <400> 232 Met Ile Cys Glu Asn His Thr Arg Val Thr Glu Phe Ile Leu Leu Gly 1 5 10 15 Phe Thr Asn Asn Pro Glu Met Gln Val Ser Leu Phe Ile Phe Phe Leu 20 25 30 Ala Ile Tyr Thr Val Thr Leu Leu Gly Asn Phe Leu Ile Val Thr Val 35 40 45 Thr Ser Val Asp Leu Ala Leu Gln Thr Pro Met Tyr Phe Phe Leu Gln 50 55 60 Asn Leu Ser Leu Leu Glu Val Cys Phe Thr Leu Val Met Val Pro Lys 65 70 75 80 Met Leu Val Asp Leu Val Ser Pro Arg Lys Ile Ile Ser Phe Val Gly 85 90 95 Cys Gly Thr Gln Met Tyr Phe Phe Phe Phe Phe Gly Ser Ser Glu Cys 100 105 110 Phe Leu Leu Ser Met Met Ala Tyr Asp Arg Phe Val Ala Ile Cys Asn 115 120 125 Pro Leu His Tyr Ser Val Ile Met Asn Arg Ser Leu Cys Leu Trp Met 130 135 140 Ala Ile Gly Ser Trp Met Ser Gly Val Pro Val Ser Met Leu Gln Thr 145 150 155 160 Ala Trp Met Met Ala Leu Pro Phe Cys Gly Pro Asn Ala Val Asp His 165 170 175 Phe Phe Cys Asp Gly Pro Pro Val Leu Lys Leu Val Thr Val Asp Thr 180 185 190 Thr Met Tyr Glu Met Gln Ala Leu Ala Ser Thr Leu Leu Phe Ile Met 195 200 205 Phe Pro Phe Cys Leu Ile Leu Val Ser Tyr Thr Arg Ile Ile Ile Thr 210 215 220 Ile Leu Arg Met Ser Ser Ala Thr Gly Arg Gln Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Leu Ile Val Val Ser Leu Phe Tyr Gly Thr Ala Ser 245 250 255 Leu Thr Tyr Leu Arg Pro Lys Ser Asn Gln Ser Pro Glu Ser Lys Lys 260 265 270 Leu Val Ser Leu Ser Tyr Thr Val Ile Thr Pro Met Leu Asn Pro Ile 275 280 285 Ile Tyr Gly Leu Arg Asn Asn Glu Val Lys Gly Ala Val Lys Arg Thr 290 295 300 Ile Thr Gln Lys Val Leu Gln Lys Leu Asp Val Phe 305 310 315 <210> 233 <211> 942 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(942) <400> 233 atg ggt gac agg gga aca agc aat cac tca gaa atg act gac ttc att 48 Met Gly Asp Arg Gly Thr Ser Asn His Ser Glu Met Thr Asp Phe Ile 1 5 10 15 ctt gca ggc ttc agg gta cgc cca gag ctc cac att ctc ctc ttc ctg 96 Leu Ala Gly Phe Arg Val Arg Pro Glu Leu His Ile Leu Leu Phe Leu 20 25 30 cta ttt ttg ttt gtt tat gcc atg atc ctt cta ggg aat gtt ggg atg 144 Leu Phe Leu Phe Val Tyr Ala Met Ile Leu Leu Gly Asn Val Gly Met 35 40 45 atg acc att att atg act gat cct cgg ctg aac aca cca atg tat ttt 192 Met Thr Ile Ile Met Thr Asp Pro Arg Leu Asn Thr Pro Met Tyr Phe 50 55 60 ttc cta ggc aat ctc tcc ttc att gat ctt ttc tat tca tct gtt att 240 Phe Leu Gly Asn Leu Ser Phe Ile Asp Leu Phe Tyr Ser Ser Val Ile 65 70 75 80 gaa ccc aag gct atg atc aac ttc tgg tct gaa aac aag tct atc tcc 288 Glu Pro Lys Ala Met Ile Asn Phe Trp Ser Glu Asn Lys Ser Ile Ser 85 90 95 ttt gca ggc tgt gtg gcc cag ctc ttt ctc ttt gcc ctc ctc att gtg 336 Phe Ala Gly Cys Val Ala Gln Leu Phe Leu Phe Ala Leu Leu Ile Val 100 105 110 act gag gga ttt ctc ctg gcg gcc atg gct tat gac cgc ttt att gcc 384 Thr Glu Gly Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Phe Ile Ala 115 120 125 atc tgc aac cct ctg ctc tac tct gtt caa atg tcc aca cgt ctg tgt 432 Ile Cys Asn Pro Leu Leu Tyr Ser Val Gln Met Ser Thr Arg Leu Cys 130 135 140 act cag ttg gtg gct ggt tcc tat ttt tgt ggc tgc att agc tca gtt 480 Thr Gln Leu Val Ala Gly Ser Tyr Phe Cys Gly Cys Ile Ser Ser Val 145 150 155 160 att cag act agc atg aca ttt act tta tct ttt tgc gct tct cgg gct 528 Ile Gln Thr Ser Met Thr Phe Thr Leu Ser Phe Cys Ala Ser Arg Ala 165 170 175 gtt gac cac ttt tac tgt gat tct cgc cca ctt cag aga ctg tct tgt 576 Val Asp His Phe Tyr Cys Asp Ser Arg Pro Leu Gln Arg Leu Ser Cys 180 185 190 tct gat ctc ttt atc cat aga atg ata tct ttt tcc tta tca tgt att 624 Ser Asp Leu Phe Ile His Arg Met Ile Ser Phe Ser Leu Ser Cys Ile 195 200 205 att atc ttg cct act atc ata gtc att ata gta tct tac atg tat att 672 Ile Ile Leu Pro Thr Ile Ile Val Ile Ile Val Ser Tyr Met Tyr Ile 210 215 220 gtg tcc aca gtt cta aag ata cat tct act gag gga cat aag aag gcc 720 Val Ser Thr Val Leu Lys Ile His Ser Thr Glu Gly His Lys Lys Ala 225 230 235 240 ttc tcc acc tgc agc tct cac ctg gga gtt gtg agt gtg ctg tat ggt 768 Phe Ser Thr Cys Ser Ser His Leu Gly Val Val Ser Val Leu Tyr Gly 245 250 255 gct gtc ttt ttt atg tat ctc act cct gac aga ttt cct gag ctg agt 816 Ala Val Phe Phe Met Tyr Leu Thr Pro Asp Arg Phe Pro Glu Leu Ser 260 265 270 aaa gtg gca tcc tta tgt tac tcc cta gtc act ccc atg ttg aat cct 864 Lys Val Ala Ser Leu Cys Tyr Ser Leu Val Thr Pro Met Leu Asn Pro 275 280 285 ttg att tac tct ctg agg aac aaa gat gtc caa gag gct cta aaa aaa 912 Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Gln Glu Ala Leu Lys Lys 290 295 300 t tt cta gag aag aaa aat att att ctt tga 942 Phe Leu Glu Lys Lys Asn Ile Ile Leu 305 310 <210> 234 <211> 313 <212> PRT <213> Homo sapiens <400> 234 Met Gly Asp Arg Gly Thr Ser Asn His Ser Glu Met Thr Asp Phe Ile 1 5 10 15 Leu Ala Gly Phe Arg Val Arg Pro Glu Leu His Ile Leu Leu Phe Leu 20 25 30 Leu Phe Leu Phe Val Tyr Ala Met Ile Leu Leu Gly Asn Val Gly Met 35 40 45 Met Thr Ile Ile Met Thr Asp Pro Arg Leu Asn Thr Pro Met Tyr Phe 50 55 60 Phe Leu Gly Asn Leu Ser Phe Ile Asp Leu Phe Tyr Ser Ser Val Ile 65 70 75 80 Glu Pro Lys Ala Met Ile Asn Phe Trp Ser Glu Asn Lys Ser Ile Ser 85 90 95 Phe Ala Gly Cys Val Ala Gln Leu Phe Leu Phe Ala Leu Leu Ile Val 100 105 110 Thr Glu Gly Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Phe Ile Ala 115 120 125 Il e Cys Asn Pro Leu Leu Tyr Ser Val Gln Met Ser Thr Arg Leu Cys 130 135 140 Thr Gln Leu Val Ala Gly Ser Tyr Phe Cys Gly Cys Ile Ser Ser Val 145 150 155 160 Ile Gln Thr Ser Met Thr Phe Thr Leu Ser Phe Cys Ala Ser Arg Ala 165 170 175 Val Asp His Phe Tyr Cys Asp Ser Arg Pro Leu Gln Arg Leu Ser Cys 180 185 190 Ser Asp Leu Phe Ile His Arg Met Ile Ser Phe Ser Leu Ser Cys Ile 195 200 205 Ile Ile Leu Pro Thr Ile Ile Val Ile Ile Val Ser Tyr Met Tyr Ile 210 215 220 Val Ser Thr Val Leu Lys Ile His Ser Thr Glu Gly His Lys Lys Ala 225 230 235 240 Phe Ser Thr Cys Ser Ser His Leu Gly Val Val Ser Val Leu Tyr Gly 245 250 255 Ala Val Phe Phe Met Tyr Leu Thr Pro Asp Arg Phe Pro Glu Leu Ser 260 265 270 Lys Val Ala Ser Leu Cys Tyr Ser Leu Val Thr Pro Met Leu Asn Pro 275 280 285 Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Gln Glu Ala Leu Lys Lys 290 295 300 Phe Leu Glu Lys Lys Asn Ile Ile Leu 305 310 <210> 235 <211> 996 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(996) <400> 235 atg agt cct gat ggg aac cac agt agt gat cca aca gag ttc gtc ctg 48 Met Ser Pro Asp Gly Asn His Ser Ser Asp Pro Thr Glu Phe Val Leu 1 5 10 15 gca ggg ctc cca aat ctc aac agc gca aga gtg gaa tta ttt tct gtg 96 Ala Gly Leu Pro Asn Leu Asn Ser Ala Arg Val Glu Leu Phe Ser Val 20 25 30 ttt ctt ctt gtc tat ctc ctg aat ctg aca ggc aat gtg ttg att gtg 144 Phe Leu Leu Val Tyr Leu Leu Asn Leu Thr Gly Asn Val Leu Ile Val 35 40 45 ggg gtg gta agg gct gat act cga cta cag acc cct atg tac ttc ttt 192 Gly Val Val Arg Ala Asp Thr Arg Leu Gln Thr Pro Met Tyr Phe Phe 50 55 60 ctg ggt aac ctg tcc tgc cta gag ata ctg ctc act tct gtc atc att 240 Leu Gly Asn Leu Ser Cys Leu Glu Ile Leu Leu Thr Ser Val Ile Ile 65 70 75 80 cca aag atg ctg agc aat ttc ctc tca agg caa cac act att tcc ttt 288 Pro Lys Met Leu Ser Asn Phe Leu Ser Arg Gln His Thr Ile Ser Phe 85 90 95 gct gca tgt atc acc caa ttc tat ttc tac ttc ttt ctc ggg gcc tcc 336 Ala Ala Cys Ile Thr Gln Phe Tyr Phe Tyr Phe Phe Leu Gly Ala Ser 100 105 110 gag ttc tta ctg ttg gct gtc atg tct gcg gat cgc tac ctg gcc atc 384 Glu Phe Leu Leu Leu Ala Val Met Ser Ala Asp Arg Tyr Leu Ala Ile 115 120 125 tgt cat cct ctg cgc tac ccc ttg ctc atg agt ggg gct gtg tgc ttt 432 Cys His Pro Leu Arg Tyr Pro Leu Leu Met Ser Gly Ala Val Cys Phe 130 135 140 cgt gtg gcc ttg gcc tgc tgg gtg ggg gga ctc gtc cct gtg ctt ggt 480 Arg Val Ala Leu Ala Cys Trp Val Gly Gly Leu Val Pro Val Leu Gly 145 150 155 160 ccc aca gtg gct gtg gcc ttg ctt cct ttc tgt aag cag ggt gct gtg 528 Pro Thr Val Ala Val Ala Leu Leu Pro Phe Cys Lys Gln Gly Ala Val 165 170 175 gta cag cac ttc ttc tgc gac agt ggc cca ctg ctc cgc ctg gct tgc 576 Val Gln His Phe Phe Cys Asp Ser Gly Pro Leu Leu Arg Leu Ala Cys 180 185 190 acc aac acc aag aag ctg gag gag act gac ttt gtc ctg gcc tcc ctc 624 Thr Asn Thr Lys Lys Leu Glu Glu Thr Asp Phe Val Leu Ala Ser Leu 195 200 205 gtc att gta tct tcc ttg ctg atc act gct gtg tcc tac ggc ctc att 672 Val Ile Val Ser Ser Leu Leu Ile Thr Ala Val Ser Tyr Gly Leu Ile 210 215 220 gtg ctg gca gtc ctg agc atc ccc tct gct tca ggc cgt cag aag gcc 720 Val Leu Ala Val Leu Ser Ile Pro Ser Ala Ser Gly Arg Gln Lys Ala 225 230 235 240 ttc tct acc tgt acc tcc cac ttg ata gtg gtg acc ctc ttc tat gga 768 Phe Ser Thr Cys Thr Ser His Leu Ile Val Val Thr Leu Phe Tyr Gly 245 250 255 agt gcc att ttt ctc tat gtg cgg cca tcg cag agt ggt tct gtg gac 816 Ser Ala Ile Phe Leu Tyr Val Arg Pro Ser Gln Ser Gly Ser Val Asp 260 265 270 act aac tgg gca gtg aca gta ata acg aca ttt gtg aca cca ctg ttg 864 Thr Asn Trp Ala Val Thr Val Ile Thr Thr Phe Val Thr Pro Leu Leu 275 280 285 aat cca ttc atc tat gcc tta cgt aat gag caa gtc aag gaa gct ttg 912 Asn Pro Phe Ile Tyr Ala Leu Arg Asn Glu Gln Val Lys Glu Ala Leu 290 295 300 aag gac atg ttt agg aag gta gtg gca ggc gtt tta ggg aat ctt tta 960 Lys Asp Met Phe Arg Lys Val Val Ala Gly Val Leu Gly Asn Leu Leu 305 310 315 320 ctt gat aaa tgt ctc agt gag aaa gca gta aag taa 996 Leu Asp Lys Cys Leu Ser Glu Lys Ala Val Lys 325 330 <210> 236 <211> 331 <212> PRT <213> Homo sapiens <400> 236 Met Ser Pro Asp Gly Asn His Ser Ser Asp Pro Thr Glu Phe Val Leu 1 5 10 15 Ala Gly Leu Pro Asn Leu Asn Ser Ala Arg Val Glu Leu Phe Ser Val 20 25 30 Phe Leu Leu Val Tyr Leu Leu Asn Leu Thr Gly Asn Val Leu Ile Val 35 40 45 Gly Val Val Arg Ala Asp Thr Arg Leu Gln Thr Pro Met Tyr Phe Phe 50 55 60 Leu Gly Asn Leu Ser Cys Leu Glu Ile Leu Leu Thr Ser Val Ile Ile 65 70 75 80 Pro Lys Met Leu Ser Asn Phe Leu Ser Arg Gln His Thr Ile Ser Phe 85 90 95 Ala Ala Cys Ile Thr Gln Phe Tyr Phe Tyr Phe Phe Leu Gly Ala Ser 100 105 110 Glu Phe Leu Leu Leu Ala Val Met Ser Ala Asp Arg Tyr Leu Ala Ile 115 120 125 Cys His Pro Leu Arg Tyr Pro Leu Leu Met Ser Gly Ala Val Cys Phe 130 135 140 Arg Val Ala Leu Ala Cys Trp Val Gly Gly Leu Val Pro Val Leu Gly 145 150 155 160 Pro Thr Val Ala Val Ala Leu Leu Pro Phe Cys Lys Gln Gly Ala Val 165 170 175 Val Gln His Phe Phe Cys Asp Ser Gly Pro Leu Leu Arg Leu Ala Cys 180 185 190 Thr Asn Thr Lys Lys Leu Glu Glu Thr Asp Phe Val Leu Ala Ser Leu 195 200 205 Val Ile Val Ser Ser Leu Leu Ile Thr Ala Val Ser Tyr Gly Leu Ile 210 215 220 Val Leu Ala Val Leu Ser Ile Pro Ser Ala Ser Gly Arg Gln Lys Ala 225 230 235 240 Phe Ser Thr Cys Thr Ser His Leu Ile Val Val Thr Leu Phe Tyr Gly 245 250 255 Ser Ala Ile Phe Leu Tyr Val Arg Pro Ser Gln Ser Gly Ser Val Asp 260 265 270 Thr Asn Trp Ala Val Thr Val Ile Thr Thr Phe Val Thr Pro Leu Leu 275 280 285 Asn Pro Phe Ile Tyr Ala Leu Arg Asn Glu Gln Val Lys Glu Ala Leu 290 295 300 Lys Asp Met Phe Arg Lys Val Val Ala Gly Val Leu Gly Asn Leu Leu 305 310 315 320 Leu Asp Lys Cys Leu Ser Glu Lys Ala Val Lys 325 330 <210> 237 <211> 831 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(831) <400> 237 atg cga aga aag aac ctc aca gag gta aca gag ttt gtt ttc ctg gga 48 Met Arg Arg Lys Asn Leu Thr Glu Val Thr Glu Phe Val Phe Leu Gly 1 5 10 15 ttc tcc aga ttc cac aaa cat cac atc act ctc ttt gtg gtt ttt ctc 96 Phe Ser Arg Phe His Lys His His Ile Thr Leu Phe Val Val Phe Leu 20 25 30 atc ctg tac aca tta act gtg gct ggc aat gcc atc atc atg acc atc 144 Ile Leu Tyr Thr Leu Thr Val Ala Gly Asn Ala Ile Ile Met Thr Ile 35 40 45 atc tgc att gac cgt cac ctc cac act ccc atg tac ttc ttc ctg agc 192 Ile Cys Ile Asp Arg His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 atg ctg gct agc tca aag aca gtg tac aca ctg ttc atc att cca cag 240 Met Leu Ala Ser Ser Lys Thr Val Tyr Thr Leu Phe Ile Ile Pro Gln 65 70 75 80 atg ctc tcc agc ttc gta acc cag acc cag cca atc tcc cta gcc ggt 288 Met Leu Ser Ser Phe Val Thr Gln Thr Gln Pro Ile Ser Leu Ala Gly 85 90 95 tgt acc acc caa acg ttc ttc ttt gtt acc ttg gcc atc aac aat tgc 336 Cys Thr Thr Gln Thr Phe Phe Phe Val Thr Leu Ala Ile Asn Asn Cys 100 105 110 ttc ttg ctc aca gtg atg ggc tat gac cac tat atg gcc atc tgc aat 384 Phe Leu Leu Thr Val Met Gly Tyr Asp His Tyr Met Ala Ile Cys Asn 115 120 125 ccc ttg aga tac agg gtc att acg agc aag aag gtg tgt gtc cag ctg 432 Pro Leu Arg Tyr Arg Val Ile Thr Ser Lys Lys Val Cys Val Gln Leu 130 135 140 gtg tgt gga gcc ttt agc att ggc ctg gcc atg gca gct gtc cag gta 480 Val Cys Gly Ala Phe Ser Ile Gly Leu Ala Met Ala Ala Val Gln Val 145 150 155 160 aca tcc ata ttt acc tta cct ttt tgt cac acg gtg gtt ggt cat ttc 528 Thr Ser Ile Phe Thr Leu Pro Phe Cys His Thr Val Val Gly His Phe 165 170 175 ttc tgt gac atc ctc cct gtc atg aaa ctc tcc tgt att aat acc act 576 Phe Cys Asp Ile Leu Pro Val Met Lys Leu Ser Cys Ile Asn Thr Thr 180 185 190 atc aat gag ata atc aat ttt gtt gtc agg tta ttt gtc atc ctg gtc 624 Ile Asn Glu Ile Ile Asn Phe Val Val Arg Leu Phe Val Ile Leu Val 195 200 205 ccc atg ggt ctg gtc ttc atc tcc tat gtc ctc atc atc tcc act gtc 672 Pro Met Gly Leu Val Phe Ile Ser Tyr Val Leu Ile Ile Ser Thr Val 210 215 220 ctc aag att gcc tca gct gag ggt tgg aag aag acc ttt gcc acc tgt 720 Leu Lys Ile Ala Ser Ala Glu Gly Trp Lys Lys Thr Phe Ala Thr Cys 225 230 235 240 gcc ttc cac ctc act gtg gtc att gtc cat tat ggc tgt gct tcc att 768 Ala Phe His Leu Thr Val Val Ile Val His Tyr Gly Cys Ala Ser Ile 245 250 255 gcc tac ctc atg ccc aag tca gaa aac tct ata gaa caa gac ctc ctt 816 Ala Tyr Leu Met Pro Lys Ser Glu Asn Ser Ile Glu Gln Asp Leu Leu 260 265 270 ctc tca gtg acc taa 831 Leu Ser Val Thr 275 <210> 238 <211> 276 <212> PRT <213> Homo sapiens <400> 238 Met Arg Arg Lys Asn Leu Thr Glu Val Thr Glu Phe Val Phe Leu Gly 1 5 10 15 Phe Ser Arg Phe His Lys His His Ile Thr Leu Phe Val Val Phe Leu 20 25 30 Ile Leu Tyr Thr Leu Thr Val Ala Gly Asn Ala Ile Ile Met Thr Ile 35 40 45 Ile Cys Ile Asp Arg His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Met Leu Ala Ser Ser Lys Thr Val Tyr Thr Leu Phe Ile Ile Pro Gln 65 70 75 80 Met Leu Ser Ser Phe Val Thr Gln Thr Gln Pro Ile Ser Leu Ala Gly 85 90 95 Cys Thr Thr Gln Thr Phe Phe Phe Val Thr Leu Ala Ile Asn Asn Cys 100 105 110 Phe Leu Leu Thr Val Met Gly Tyr Asp His Tyr Met Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Arg Val Ile Thr Ser Lys Lys Val Cys Val Gln Leu 130 135 140 Val Cys Gly Ala Phe Ser Ile Gly Leu Ala Met Ala Ala Val Gln Val 145 150 155 160 Thr Ser Ile Phe Thr Leu Pro Phe Cys His Thr Val Val Gly His Phe 165 170 175 Phe Cys Asp Ile Leu Pro Val Met Lys Leu Ser Cys Ile Asn Thr Thr 180 185 190 Ile Asn Glu Ile Ile Asn Phe Val Val Arg Leu Phe Val Ile Leu Val 195 200 205 Pro Met Gly Leu Val Phe Ile Ser Tyr Val Leu Ile Ile Ser Thr Val 210 215 220 Leu Lys Ile Ala Ser Ala Glu Gly Trp Lys Lys Thr Phe Ala Thr Cys 225 230 235 240 Ala Phe His Leu Thr Val Val Ile Val His Tyr Gly Cys Ala Ser Ile 245 250 255 Ala Tyr Leu Met Pro Lys Ser Glu Asn Ser Ile Glu Gln Asp Leu Leu 260 265 270 Leu Ser Val Thr 275 <210> 239 <211> 930 <21 2> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(930) <400> 239 atg aag aga aag aac ttc aca gaa gtg tca gaa ttc att ttc ttg gga 48 Met Lys Arg Lys Asn Phe Thr Glu Val Ser Glu Phe Ile Phe Leu Gly 1 5 10 15 ttt tct agc ttt gga aag cat cag ata acc ctc ttt gtg gtt ttc cta 96 Phe Ser Ser Phe Gly Lys His Gln Ile Thr Leu Phe Val Val Phe Leu 20 25 30 act gtc tac att tta act ctg gtt gct aac atc atc att gtg act atc 144 Thr Val Tyr Ile Leu Thr Leu Val Ala Asn Ile Ile Ile Val Thr Ile 35 40 45 atc tgc att gac cat cat ctc cac act ccc atg tat ttc ttc cta agc 192 Ile Cys Ile Asp His His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 atg ctg gct agt tca gag acg gtg tac aca ctg gtc att gtg cca cga 240 Met Leu Ala Ser Ser Glu Thr Val Tyr Thr Leu Val Ile Val Pro Arg 65 70 75 80 atg ctt ttg agc ctc att ttt cat aac caa cct atc tcc ttg gca ggc 288 Met Leu Leu Ser Leu Ile Phe His Asn Gln Pro Ile Ser Leu Ala Gly 85 90 95 tgt gct aca caa atg ttc ttt ttt gtt atc ttg gcc act aat aat tgc 336 Cys Ala Thr Gln Met Phe Phe Phe Val Ile Leu Ala Thr Asn Asn Cys 100 105 110 ttc ctg ctt act gca atg ggg tat gac cgc tat gtg gcc atc tgc aga 384 Phe Leu Leu Thr Ala Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys Arg 115 120 125 ccc ctg aga tac act gtc atc atg agc aag gga cta tgt gcc cag ctg 432 Pro Leu Arg Tyr Thr Val Ile Met Ser Lys Gly Leu Cys Ala Gln Leu 130 135 140 gtg tgt ggg tcc ttt ggc att ggt ctg act atg gca gtt ctc cat gtg 480 Val Cys Gly Ser Phe Gly Ile Gly Leu Thr Met Ala Val Leu His Val 145 150 155 160 aca gcc atg ttc aat ttg ccg ttc tgt ggc aca gtg gta gac cac ttc 528 Thr Ala Met Phe Asn Leu Pro Phe Cys Gly Thr Val Val Asp His Phe 165 170 175 ttt tgt gac att tac cca gtc atg aaa ctt tct tgc att gat acc act 576 Phe Cys Asp Ile Tyr Pro Val Met Lys Leu Ser Cys Ile Asp Thr Thr 180 185 190 atc aat gag ata ata aat tat ggt gta agt tca ttt gtg att ttt gtg 624 Ile Asn Glu Ile Ile Asn Tyr Gly Val Ser Ser Phe Val Ile Phe Val 195 200 205 ccc ata ggc ctg ata ttt atc tcc tat gtc ctt gtc atc tct tcc atc 672 Pro Ile Gly Leu Ile Phe Ile Ser Tyr Val Leu Val Ile Ser Ser Ile 210 215 220 ctt caa att gcc tca gct gag ggc cgg aag aag acc ttt gcc acc tgt 720 Leu Gln Ile Ala Ser Ala Glu Gly Arg Lys Lys Thr Phe Ala Thr Cys 225 230 235 240 gtc tcc cac ctc act gtg gtt att gtc cac tgt ggc tgt gcc tcc att 768 Val Ser His Leu Thr Val Val Ile Val His Cys Gly Cys Ala Ser Ile 245 250 255 gcc tac ctc aag ccg aag tca gaa agt tca ata gaa aaa gac ctt gtt 816 Ala Tyr Leu Lys Pro Lys Ser Glu Ser Ser Ile Glu Lys Asp Leu Val 260 265 270 ctc tca gtg acg tac acc atc atc act ccc ttg ctg aac cct gtt gtt 864 Leu Ser Val Thr Tyr Thr Ile Ile Thr Pro Leu Leu Asn Pro Val Val 275 280 285 tac agt ctg aga aac aag gag gta aag gat gcc cta tgc aga gtt gtg 912 Tyr Ser Leu Arg Asn Lys Glu Val Lys Asp Ala Leu Cys Arg Val Val 290 295 300 ggc aga aat att tct taa 930 Gly Arg Asn Ile Ser 305 310 <210> 240 <211> 309 <212> PRT <213> Homo sapiens <400> 240 Met Lys Arg Lys Asn Phe Thr Glu Val Ser Glu Phe Ile Phe Leu Gly 1 5 10 15 Phe Ser Ser Phe Gly Lys His Gln Ile Thr Leu Phe Val Val Phe Leu 20 25 30 Thr Val Tyr Ile Leu Thr Leu Val Ala Asn Ile Ile Ile Val Thr Ile 35 40 45 Ile Cys Ile Asp His His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Met Leu Ala Ser Ser Glu Thr Val Tyr Thr Leu Val Ile Val Pro Arg 65 70 75 80 Met Leu Leu Ser Leu Ile Phe His Asn Gln Pro Ile Ser Leu Ala Gly 85 90 95 Cys Ala Thr Gln Met Phe Phe Phe Val Ile Leu Ala Thr Asn Asn Cys 100 105 110 Phe Leu Leu Thr Ala Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys Arg 115 120 125 Pro Leu Arg Tyr Thr Val Ile Met Ser Lys Gly Leu Cys Ala Gln Leu 130 135 140 Val Cys Gly Ser Phe Gly Ile Gly Leu Thr Met Ala Val Leu His Val 145 150 155 160 Thr Ala Met Phe Asn Leu Pro Phe Cys Gly Thr Val Val Asp His Phe 165 170 175 Phe Cys Asp Ile Tyr Pro Val Met Lys Leu Ser Cys Ile Asp Thr Thr 180 185 190 Ile Asn Glu Ile Ile Asn Tyr Gly Val Ser Ser Phe Val Ile Phe Val 195 200 205 Pro Ile Gly Leu Ile Phe Ile Ser Tyr Val Leu Val Ile Ser Ser Ile 210 215 220 Leu Gln Ile Ala Ser Ala Glu Gly Arg Lys Lys Thr Phe Ala Thr Cys 225 230 235 240 Val Ser His Leu Thr Val Val Ile Val His Cys Gly Cys Ala Ser Ile 245 250 255 Ala Tyr Leu Lys Pro Lys Ser Glu Ser Ser Ile Glu Lys Asp Leu Val 260 265 270 Leu Ser Val Thr Tyr Thr Ile Ile Thr Pro Leu Leu Asn Pro Val Val 275 280 285 Tyr Ser Leu Arg Asn Lys Glu Val Lys Asp Ala Leu Cys Arg Val Val 290 295 300 Gly Arg Asn Ile Ser 305 <210> 241 <211> 936 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(936) <400> 241 atg gaa aaa ata aac aac gta act gaa ttc att ttc tgg ggt ctt tct 48 Met Glu Lys Ile Asn Asn Val Thr Glu Phe Ile Phe Trp Gly Leu Ser 1 5 10 15 cag agc cca gag att gag aaa gtt tgt ttt gtg gtg ttt tct ttc ttc 96 Gln Ser Pro Glu Ile Glu Lys Val Cys Phe Val Val Phe Ser Phe Phe 20 25 30 tac ata atc att ctt ctg gga aat ctc ctc atc atg ctg aca gtt tgc 144 Tyr Ile Ile Ile Leu Leu Gly Asn Leu Leu Ile Met Leu Thr Val Cys 35 40 45 ctg agc aac ctg ttt aag tca ccc atg tat ttc ttt ctc agc ttc ttg 192 Leu Ser Asn Leu Phe Lys Ser Pro Met Tyr Phe Phe Leu Ser Phe Leu 50 55 60 tct ttt gtg gac att tgt tac tct tca gtc aca gct ccc aag atg att 240 Ser Phe Val Asp Ile Cys Tyr Ser Ser Val Thr Ala Pro Lys Met Ile 65 70 75 80 gtt gac ctg tta gca aag gac aaa acc atc tcc tat gtg ggg tgc atg 288 Val Asp Leu Leu Ala Lys Asp Lys Thr Ile Ser Tyr Val Gly Cys Met 85 90 95 ttg caa ctg ctt gga gta cat ttc ttt ggt tgc act gag atc ttc atc 336 Leu Gln Leu Leu Gly Val His Phe Phe Gly Cys Thr Glu Ile Phe Ile 100 105 110 ctt act gta atg gcc tat gat cgt tat gtg gct atc tgt aaa ccc cta 384 Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 cat tat atg acc atc atg aac cgg gag aca tgc aat aaa atg tta tta 432 His Tyr Met Thr Ile Met Asn Arg Glu Thr Cys Asn Lys Met Leu Leu 130 135 140 ggg acg tgg gta ggt ggg ttc tta cac tcc att atc caa gtg gct ctg 480 Gly Thr Trp Val Gly Gly Phe Leu His Ser Ile Ile Gln Val Ala Leu 145 150 155 160 gta gtc caa cta ccc ttt tgt gga ccc aat gag ata gat cac tac ttt 528 Val Val Gln Leu Pro Phe Cys Gly Pro Asn Glu Ile Asp His Tyr Phe 165 170 175 tgt gat gtt cac cct gtg ttg aaa ctt gcc tgc aca gaa aca tac att 576 Cys Asp Val His Pro Val Leu Lys Leu Ala Cys Thr Glu Thr Tyr Ile 180 185 190 gtt ggt gtt gtt gtg aca gcc aac agt ggt acc att gct ctg ggg agt 624 Val Gly Val Val Val Thr Ala Asn Ser Gly Thr Ile Ala Leu Gly Ser 195 200 205 ttt gtt atc ttg cta atc tcc tac agc atc atc cta gtt tcc ctg aga 672 Phe Val Ile Leu Leu Ile Ser Tyr Ser Ile Ile Leu Val Ser Leu Arg 210 215 220 aag cag tca gca gaa ggc agg cgc aaa gcc ctc tcc acc tgt ggc tcc 720 Lys Gln Ser Ala Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Gly Ser 225 230 235 240 cac att gcc atg gtc gtt atc ttt ttc ggc ccc tgt act ttt atg tac 768 His Ile Ala Met Val Val Ile Phe Phe Gly Pro Cys Thr Phe Met Tyr 245 250 255 atg cgc cct gat acg acc ttt tca gag gat aag atg gtg gct gta ttt 816 Met Arg Pro Asp Thr Thr Phe Ser Glu Asp Lys Met Val Ala Val Phe 260 265 270 tac acc att atc act ccc atg tta aat cct ctg att tat aca ctg aga 864 Tyr Thr Ile Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 aat gca gaa gta aag aat gca atg aag aaa ctg tgg ggc aga aat gtt 912 Asn Ala Glu Val Lys Asn Ala Met Lys Lys Leu Trp Gly Arg Asn Val 290 295 300 ttc ttg gag gct aaa ggg aaa tag 936 Ph e Leu Glu Ala Lys Gly Lys 305 310 <210> 242 <211> 311 <212> PRT <213> Homo sapiens <400> 242 Met Glu Lys Ile Asn Asn Val Thr Glu Phe Ile Phe Trp Gly Leu Ser 1 5 10 15 Gln Ser Pro Glu Ile Glu Lys Val Cys Phe Val Val Phe Ser Phe Phe 20 25 30 Tyr Ile Ile Ile Leu Leu Gly Asn Leu Leu Ile Met Leu Thr Val Cys 35 40 45 Leu Ser Asn Leu Phe Lys Ser Pro Met Tyr Phe Phe Leu Ser Phe Leu 50 55 60 Ser Phe Val Asp Ile Cys Tyr Ser Ser Val Thr Ala Pro Lys Met Ile 65 70 75 80 Val Asp Leu Leu Ala Lys Asp Lys Thr Ile Ser Tyr Val Gly Cys Met 85 90 95 Leu Gln Leu Leu Gly Val His Phe Phe Gly Cys Thr Glu Ile Phe Ile 100 105 110 Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Met Thr Ile Met Asn Arg Glu Thr Cys Asn Lys Met Leu Leu 130 135 140 Gly Thr Trp Val Gly Gly Phe Leu His Ser Ile Ile Gln Val Ala Leu 145 150 155 160 Val Val Gln Leu Pro Phe Cys Gly Pro Asn Glu Ile Asp His Tyr Phe 165 170 175 Cys Asp Val His Pro Val Leu Lys Leu Ala Cys Thr Glu Thr Tyr Ile 180 185 190 Val Gly Val Val Val Thr Ala Asn Ser Gly Thr Ile Ala Leu Gly Ser 195 200 205 Phe Val Ile Leu Leu Ile Ser Tyr Ser Ile Ile Leu Val Ser Leu Arg 210 215 220 Lys Gln Ser Ala Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Gly Ser 22 5 230 235 240 His Ile Ala Met Val Val Ile Phe Phe Gly Pro Cys Thr Phe Met Tyr 245 250 255 Met Arg Pro Asp Thr Thr Phe Ser Glu Asp Lys Met Val Ala Val Phe 260 265 270 Tyr Thr Ile Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ala Glu Val Lys Asn Ala Met Lys Lys Leu Trp Gly Arg Asn Val 290 295 300 Phe Leu Glu Ala Lys Gly Lys 305 310 <210> 243 <211> 1053 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1053) <400> 243 atg act atg ata cca caa att gat ctg aag caa att ttc ctt tgt cct 48 Met Thr Met Ile Pro Gln Ile Asp Leu Lys Gln Ile Phe Leu Cys Pro 1 5 10 15 aat tgc aga cta tac atg atc cct gtt gga gct ttc atc ttt tcc ttg 96 Asn Cys Arg Leu Tyr Met Ile Pro Val Gly Ala Phe Ile Phe Ser Leu 20 25 30 gga aac atg caa aac caa agc ttt gta act gag ttt gtc ctc ctg gga 144 Gly Asn Met Gln Asn Gln Ser Phe Val Thr Glu Phe Val Leu Leu Gly 35 40 45 ctt tca cag aat cca aat gtt cag gaa ata gta ttt gtt gta ttt ttg 192 Leu Ser Gln Asn Pro Asn Val Gln Glu Ile Val Phe Val Val Phe Leu 50 55 60 ttt gtc tac att gca act gtt ggg ggc aac atg cta att gta gta acc 240 Phe Val Tyr Ile Ala Thr Val Gly Gly Asn Met Leu Ile Val Val Thr 65 70 75 80 att ctc agc agc cct gct ctt ctg gtg tct cct atg tac ttc ttc ttg 288 Ile Leu Ser Ser Pro Ala Leu Leu Val Ser Pro Met Tyr Phe Phe Leu 85 90 95 ggc ttc ctg tcc ttc ctg gat gcg tgc ttc tca tct gtc atc acc cca 336 Gly Phe Leu Ser Phe Leu Asp Ala Cys Phe Ser Ser Val Ile Thr Pro 100 105 110 aag atg att gta gac tcc ctc tat gtg aca aaa acc atc tct ttt gaa 384 Lys Met Ile Val Asp Ser Leu Tyr Val Thr Lys Thr Ile Ser Phe Glu 115 120 125 ggc tgc atg atg cag ctc ttt gct gaa cac ttc ttt gct ggg gtg gag 432 Gly Cys Met Met Gln Leu Phe Ala Glu His Phe Phe Ala Gly Val Glu 130 135 140 gtg att gtc ctc aca gcc atg gcc tat gat cgt tat gtg gcc att tgc 480 Val Ile Val Leu Thr Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys 145 150 155 160 aag ccc ttg cat tac tct tct atc atg aac agg agg ctc tgt ggc att 528 Lys Pro Leu His Tyr Ser Ser Ile Met Asn Arg Arg Leu Cys Gly Ile 165 170 175 ctg atg ggg gta gcc tgg aca ggg ggc ctc ttg cat tcc atg ata caa 576 Leu Met Gly Val Ala Trp Thr Gly Gly Leu Leu His Ser Met Ile Gln 180 185 190 att ctt ttt act ttc cag ctt ccc ttt tgt ggc ccc aat gtc atc aat 624 Ile Leu Phe Thr Phe Gln Leu Pro Phe Cys Gly Pro Asn Val Ile Asn 195 200 205 cac ttt atg tgt gac ttg tac ccg tta ctg gag ctt gcc tgc act gat 672 His Phe Met Cys Asp Leu Tyr Pro Leu Leu Glu Leu Ala Cys Thr Asp 210 215 220 act cac atc ttt ggc ctc atg gtg gtc atc aac agt ggg ttt atc tgc 720 Thr His Ile Phe Gly Leu Met Val Val Ile Asn Ser Gly Phe Ile Cys 225 230 235 240 atc ata aac ttc tcc ttg ttg ctt gtc tcc tat gct gtc atc ttg ctc 768 Ile Ile Asn Phe Ser Leu Leu Leu Val Ser Tyr Ala Val Ile Leu Leu 245 250 255 tct ctg aga aca cac agt tct gaa ggg cgc tgg aaa gct ctc tcc acc 816 Ser Leu Arg Thr His Ser Ser Glu Gly Arg Trp Lys Ala Leu Ser Thr 260 265 270 tgt gga tct cac att gct gtt gtg att ttg ttc ttt gtc cca tgc ata 864 Cys Gly Ser His Ile Ala Val Val Ile Leu Phe Phe Val Pro Cys Ile 275 280 285 ttt gta tat aca cga cct cca tct gct ttt tcc ctt gac aaa atg gcg 912 Phe Val Tyr Thr Arg Pro Pro Ser Ala Phe Ser Leu Asp Lys Met Ala 290 295 300 gca ata ttt tat atc atc tta aat ccc ttg ctc aat cct ttg att tac 960 Ala Ile Phe Tyr Ile Ile Leu Asn Pro Leu Leu Asn Pro Leu Ile Tyr 305 310 315 320 act ttc agg aat aag gaa gta aaa cag gcc atg agg aga ata tgg aac 1008 Thr Phe Arg Asn Lys Glu Val Lys Gln Ala Met Arg Arg Ile Trp Asn 325 330 335 aga ctg atg gtg gtt tct gat gag aaa gaa aat att aaa ctt taa 1053 Arg Leu Met Val Val Ser Asp Glu Lys Glu Asn Ile Lys Leu 340 345 350 <210> 244 <211> 350 <212> PRT <213> Homo sapiens <400> 244 Met Thr Met Ile Pro Gln Ile Asp Leu Lys Gln Ile Phe Leu Cys Pro 1 5 10 15 Asn Cys Arg Leu Tyr Met Ile Pro Val Gly Ala Phe Ile Phe Ser Leu 20 25 30 Gly Asn Met Gln Asn Gln Ser Phe Val Thr Glu Phe Val Leu Leu Gly 35 40 45 Leu Ser Gln Asn Pro Asn Val Gln Glu Ile Val Phe Val Val Phe Leu 50 55 60 Phe Val Tyr Ile Ala Thr Val Gly Gly Asn Met Leu Ile Val Val Thr 65 70 75 80 Ile Leu Ser Ser Pro Ala Leu Leu Val Ser Pro Met Tyr Phe Phe Leu 85 90 95 Gly Phe Leu Ser Phe Leu Asp Ala Cys Phe Ser Ser Val Ile Thr Pro 100 105 110 Lys Met Ile Val Asp Ser Leu Tyr Val Thr Lys Thr Ile Ser Phe Glu 115 120 125 Gly Cys Met Met Gln Leu Phe Ala Glu His Phe Phe Ala Gly Val Glu 130 135 140 Val Ile Val Leu Thr Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys 145 150 155 160 Lys Pro Leu His Tyr Ser Ser Ile Met Asn Arg Arg Leu Cys Gly Ile 165 170 175 Leu Met Gly Val Ala Trp Thr Gly Gly Leu Leu His Ser Met Ile Gln 180 185 190 Ile Leu Phe Thr Phe Gln Leu Pro Phe Cys Gly Pro Asn Val Ile Asn 195 200 205 His Phe Met Cys Asp Leu Tyr Pro Leu Leu Glu Leu Ala Cys Thr Asp 210 215 220 Thr His Ile Phe Gly Leu Met Val Val Ile Asn Ser Gly Phe Ile Cys 225 230 235 240 Ile Ile Asn Phe Ser Leu Leu Leu Val Ser Tyr Ala Val Ile Leu Leu 245 250 255 Ser Leu Arg Thr His Ser Ser Glu Gly Arg Trp Lys Ala Leu Ser Thr 260 265 270 Cys Gly Ser His Ile Ala Val Val Ile Leu Phe Phe Val Pro Cys Ile 275 280 285 Phe Val Tyr Thr Arg Pro Pro Ser Ala Phe Ser Leu Asp Lys Met Ala 290 295 300 Ala Ile Phe Tyr Ile Ile Leu Asn Pro Leu Leu Asn Pro Leu Ile Tyr 305 310 315 320 Thr Phe Arg Asn Lys Glu Val Lys Gln Ala Met Arg Arg Ile Trp Asn 325 330 335 Arg Leu Met Val Val Ser Asp Glu Lys Glu Asn Ile Lys Leu 340 345 350 <210> 245 <211> 981 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(981) <400> 245 atg tca ttt cag gtg act tat atg ttc tat cta cac tgg acc atg gaa 48 Met Ser Phe Gln Val Thr Tyr Met Phe Tyr Leu His Trp Thr Met Glu 1 5 10 15 aaa agc aat aat agc act ttg ttt att ctc ttg ggg ttt tcc caa aat 96 Lys Ser Asn Asn Ser Thr Leu Phe Ile Leu Leu Gly Phe Ser Gln Asn 20 25 30 aag aac att gaa gtc ctc tgc ttt gta tta ttt ttg ttt tgc tac att 144 Lys Asn Ile Glu Val Leu Cys Phe Val Leu Phe Leu Phe Cys Tyr Ile 35 40 45 gct att tgg atg gga aac tta ctc ata atg att tct atc acg tgc acc 192 Ala Ile Trp Met Gly Asn Leu Leu Ile Met Ile Ser Ile Thr Cys Thr 50 55 60 cag ctc att cac caa ccc atg tat ttc ttc ctc aat tac ctc tca ctc 240 Gln Leu Ile His Gln Pro Met Tyr Phe Phe Leu Asn Tyr Leu Ser Leu 65 70 75 80 tcc gac ctt tgc tac aca tcc aca gtg acc ccc aaa tta atg gtt gac 288 Ser Asp Leu Cys Tyr Thr Ser Thr Val Thr Pro Lys Leu Met Val Asp 85 90 95 tta ctg gca gaa aga aag acc att tcc tat aat aac tgt atg ata caa 336 Leu Leu Ala Glu Arg Lys Thr Ile Ser Tyr Asn Asn Cys Met Ile Gln 100 105 110 ctc ttt acc acc cat ttt ttt gga ggc ata gag atc ttc att ctc aca 384 Leu Phe Thr Thr His Phe Phe Gly Gly Ile Glu Ile Phe Ile Leu Thr 115 120 125 ggg atg gcc tat gac cgc tat gtg gcc att tgc aag ccc ctg cac tac 432 Gly Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu His Tyr 130 135 140 acc att att atg agc agg caa aag tgt aac aca atc atc ata gtt tgt 480 Thr Ile Ile Met Ser Arg Gln Lys Cys Asn Thr Ile Ile Ile Val Cys 145 150 155 160 tgt act ggg gga ttt ata cat tct gcc agt cag ttt ctt ctc acc atc 528 Cys Thr Gly Gly Phe Ile His Ser Ala Ser Gln Phe Leu Leu Thr Ile 165 170 175 ttt gta cca ttt tgt ggc cca aat gag ata gat cac tac ttc tgt gat 576 Phe Val Pro Phe Cys Gly Pro Asn Glu Ile Asp His Tyr Phe Cys Asp 180 185 190 gtg tat cct ttg ctg aaa ttg gcc tgt tct aat ata cac atg ata ggt 624 Val Tyr Pro Leu Leu Lys Leu Ala Cys Ser Asn Ile His Met Ile Gly 195 200 205 ctc tta gtc att gct aat tca ggc tta att gct ttg gtg aca ttt gtt 672 Leu Leu Val Ile Ala Asn Ser Gly Leu Ile Ala Leu Val Thr Phe Val 210 215 220 gtc ttg ttg ttg tct tat gtt ttt ata ttg tat acc atc aga gca tac 720 Val Leu Leu Leu Ser Tyr Val Phe Ile Leu Tyr Thr Ile Arg Ala Tyr 225 230 235 240 tct gca gag aga cgc agc aaa gct ctt gcc act tgt agt tct cat gta 768 Ser Ala Glu Arg Arg Ser Lys Ala Leu Ala Thr Cys Ser Ser His Val 245 250 255 att gtt gtg gtc ctg ttt ttt gct cct gca ttg ttc att tac att aga 816 Ile Val Val Val Leu Phe Phe Ala Pro Ala Leu Phe Ile Tyr Ile Arg 260 265 270 ccg gtc aca aca ttc tca gaa gat aaa gtg ttt gcc ctt ttt tat acc 864 Pro Val Thr Thr Phe Ser Glu Asp Lys Val Phe Ala Leu Phe Tyr Thr 275 280 285 atc att gct ccc atg ttc aac cct ctc ata tac acg ctg aga aac aca 912 Ile Ile Ala Pro Met Phe Asn Pro Leu Ile Tyr Thr Leu Arg Asn Thr 290 295 300 gag atg aag aac gcc atg agg aaa gtg tgg tgt tgt caa ata ctc ctg 960 Glu Met Lys Asn Ala Met Arg Lys Val Trp Cys Cys Gln Ile Leu Leu 305 310 315 320 aaa aga aat caa ctt ttc tga 981 Lys Arg Asn Gln Leu Phe 325 <210> 246 <211> 326 <212> PRT <213> Homo sapiens <400> 246 Met Ser Phe Gln Val Thr Tyr Met Phe Tyr Leu His Trp Thr Met Glu 1 5 10 15 Lys Ser Asn Asn Ser Thr Leu Phe Ile Leu Leu Gly Phe Ser Gln Asn 20 25 30 Lys Asn Ile Glu Val Leu Cys Phe Val Leu Phe Leu Phe Cys Tyr Ile 35 40 45 Ala Ile Trp Met Gly Asn Leu Leu Ile Met Ile Ser Ile Thr Cys Thr 50 55 60 Gln Leu Ile His Gln Pro Met Tyr Phe Phe Leu Asn Tyr Leu Ser Leu 65 70 75 80 Ser Asp Leu Cys Tyr Thr Ser Thr Val Thr Pro Lys Leu Met Val Asp 85 90 95 Leu Leu Ala Glu Arg Lys Thr Ile Ser Tyr Asn Asn Cys Met Ile Gln 100 105 110 Leu Phe Thr Thr His Phe Phe Gly Gly Ile Glu Ile Phe Ile Leu Thr 115 120 125 Gly Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu His Tyr 130 135 140 Thr Ile Ile Met Ser Arg Gln Lys Cys Asn Thr Ile Ile Ile Val Cys 145 150 155 160 Cys Thr Gly Gly Phe Ile His Ser Ala Ser Gln Phe Leu Leu Thr Ile 165 170 175 Phe Val Pro Phe Cys Gly Pro Asn Glu Ile Asp His Tyr Phe Cys Asp 180 185 190 Val Tyr Pro Leu Leu Lys Leu Ala Cys Ser Asn Ile His Met Ile Gly 195 200 205 Leu Leu Val Ile Ala Asn Ser Gly Leu Ile Ala Leu Val Thr Phe Val 210 215 220 Val Leu Leu Leu Ser Tyr Val Phe Ile Leu Tyr Thr Ile Arg Ala Tyr 225 230 235 240 Ser Ala Glu Arg Arg Ser Lys Ala Leu Ala Thr Cys Ser Ser His Val 245 250 255 Ile Val Val Val Leu Phe Phe Ala Pro Ala Leu Phe Ile Tyr Ile Arg 260 265 270 Pro Val Thr Thr Phe Ser Glu Asp Lys Val Phe Ala Leu Phe Tyr Thr 275 280 285 Ile Ile Ala Pro Met Phe Asn Pro Leu Ile Tyr Thr Leu Arg Asn Thr 290 295 300 Glu Met Lys Asn Ala Met Arg Lys Val Trp Cys Cys Gln Ile Leu Leu 305 310 315 320 Lys Arg Asn Gln Leu Phe 325 <210> 247 <211> 1014 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1014) <400> 247 atg gag gca gaa ata aag atg tta ttt gaa acc aat gag aca aaa gac 48 Met Glu Ala Glu Ile Lys Met Leu Phe Glu Thr Asn Glu Thr Lys Asp 1 5 10 15 aca aca tac cag aat ctc tgg gac acc ttc aaa gca gtg tgt aga ggg 96 Thr Thr Tyr Gln Asn Leu Trp Asp Thr Phe Lys Ala Val Cys Arg Gly 20 25 30 aaa ttt ata gca cta aat gcc cgc aag aga aag cag aaa aga tct aaa 144 Lys Phe Ile Ala Leu Asn Ala Arg Lys Arg Lys Gln Lys Arg Ser Lys 35 40 45 att gac act ctc aca tca caa tta aaa gaa cta gag aag caa gag caa 192 Ile Asp Thr Leu Thr Ser Gln Leu Lys Glu Leu Glu Lys Gln Glu Gln 50 55 60 aca cat tca aaa gct agc aga agg caa gaa ata act aag atc aga gca 240 Thr His Ser Lys Ala Ser Arg Arg Gln Glu Ile Thr Lys Ile Arg Ala 65 70 75 80 gaa ctg aag gaa ata gag aca caa aaa acc ctt caa aaa atc aat gaa 288 Glu Leu Lys Glu Ile Glu Thr Gln Lys Thr Leu Gln Lys Ile Asn Glu 85 90 95 tcc agg agc agg ttt ttt gaa aag atc aac aaa att gat cga ccn nnn 336 Ser Arg Ser Arg Phe Phe Glu Lys Ile Asn Lys Ile Asp Arg Pro Xaa 100 105 110 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 384 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 115 120 125 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 432 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 130 135 140 gtt gac cgc tat gtg gac atc tgt aag ccc ttg cac tac atg acc atc 480 Val Asp Arg Tyr Val Asp Ile Cys Lys Pro Leu His Tyr Met Thr Ile 145 150 155 160 ata agc cag tgg gtc tgt ggt gtt ttg atg gct gtg gcc tgg gtg gga 528 Ile Ser Gln Trp Val Cys Gly Val Leu Met Ala Val Ala Trp Val Gly 165 170 175 tcc tgt gtg cat tct tta gtt cag att ttt ctt gcc ctg agt ttg cca 576 Ser Cys Val His Ser Leu Val Gln Ile Phe Leu Ala Leu Ser Leu Pro 180 185 190 ttc tgt ggc ccc aat gtg atc aat cac tgt ttc tgt gac ttg cag ccc 624 Phe Cys Gly Pro Asn Val Ile Asn His Cys Phe Cys Asp Leu Gln Pro 195 200 205 ttg ttg aaa caa gcc tgt tca gaa acc tat gtg gtt aac cta ctc ctg 672 Leu Leu Lys Gln Ala Cys Ser Glu Thr Tyr Val Val Asn Leu Leu Leu 210 215 220 gtt tcc aat agt ggg gcc att tgt gca gtg agt tat gtc atg cta ata 720 Val Ser Asn Ser Gly Ala Ile Cys Ala Val Ser Tyr Val Met Leu Ile 225 230 235 240 ttc tcc tat gtc atc ttc ttg cat tct ctg aga aac cac agt gct gaa 768 Phe Ser Tyr Val Ile Phe Leu His Ser Leu Arg Asn His Ser Ala Glu 245 250 255 gtg ata aag aaa gca ctt tcc aca tgt gtc tcc cac atc att gtg gtc 816 Val Ile Lys Lys Ala Leu Ser Thr Cys Val Ser His Ile Ile Val Val 260 265 270 atc ttg ttc ttt gga cct tgc ata ttt atg tac aca tgc cct gca acc 864 Ile Leu Phe Phe Gly Pro Cys Ile Phe Met Tyr Thr Cys Pro Ala Thr 275 280 285 gta ttc ccc atg gat aag atg ata gct gta ttt tat aca gtt gga aca 912 Val Phe Pro Met Asp Lys Met Ile Ala Val Phe Tyr Thr Val Gly Thr 290 295 300 tct ttt ctc aac cct gtg att tac acg ctg aag aat aca gaa gtg aaa 960 Ser Phe Leu Asn Pro Val Ile Tyr Thr Leu Lys Asn Thr Glu Val Lys 305 310 315 320 agt gcc atg agg aag ctt tgg agc aag aaa ttg atc aca gat gac aaa 1008 Ser Ala Met Arg Lys Leu Trp Ser Lys Lys Leu Ile Thr Asp Asp Lys 325 330 335 aga taa 1014 Arg <210> 248 <211> 337 <212> PRT <213> Homo sapiens <400> 248 Met Glu Ala Glu Ile Lys Met Leu Phe Glu Thr Asn Glu Thr Lys Asp 1 5 10 15 T hr Thr Tyr Gln Asn Leu Trp Asp Thr Phe Lys Ala Val Cys Arg Gly 20 25 30 Lys Phe Ile Ala Leu Asn Ala Arg Lys Arg Lys Gln Lys Arg Ser Lys 35 40 45 Ile Asp Thr Leu Thr Ser Gln Leu Lys Glu Leu Glu Lys Gln Glu Gln 50 55 60 Thr His Ser Lys Ala Ser Arg Arg Gln Glu Ile Thr Lys Ile Arg Ala 65 70 75 80 Glu Leu Lys Glu Ile Glu Thr Gln Lys Thr Leu Gln Lys Ile Asn Glu 85 90 95 Ser Arg Ser Arg Phe Phe Glu Lys Ile Asn Lys Ile Asp Arg Pro Xaa 100 105 110 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 115 120 125 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 130 135 140 Val Asp Arg Tyr Val Asp Ile Cys Lys Pro Leu His Tyr Met Thr Ile 145 150 155 160 Ile Ser Gln Trp Val Cys Gly Val Leu Met Ala Val Ala Trp Val Gly 165 170 175 Ser Cys Val His Ser Leu Val Gln Ile Phe Leu Ala Leu Ser Leu Pro 180 185 190 Phe Cys Gly Pro Asn Val Ile Asn His Cys Phe Cys Asp Leu Gln Pro 195 200 205 Leu Leu Lys Gln Ala Cys Ser Glu Thr Tyr Val Val Asn Leu Leu Leu 210 215 220 Val Ser Asn Ser Gly Ala Ile Cys Ala Val Ser Tyr Val Met Leu Ile 225 230 235 240 Phe Ser Tyr Val Ile Phe Leu His Ser Leu Arg Asn His Ser Ala Glu 245 250 255 Val Ile Lys Lys Ala Leu Ser Thr Cys Val Ser His Ile Ile Val Val 260 265 270 Ile Leu Phe Phe Gly Pro Cys Ile Phe Met Tyr Thr Cys Pro Ala Thr 275 280 285 Val Phe Pro Met Asp Lys Met Ile Ala Val Phe Tyr Thr Val Gly Thr 290 295 300 Ser Phe Leu Asn Pro Val Ile Tyr Thr Leu Lys Asn Thr Glu Val Lys 305 310 315 320 Ser Ala Met Arg Lys Leu Trp Ser Lys Lys Leu Ile Thr Asp Asp Lys 325 330 335 Arg <210> 249 <211> 834 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(834) <400> 249 atg ggc aac ctc ctt atc atg gtg acc atc atg gcc agc cag tcc ctg 48 Met Gly Asn Leu Leu Ile Met Val Thr Ile Met Ala Ser Gln Ser Leu 1 5 10 15 ggt tcc ccc atg tac ttt ttt ctg gct tct tta tca ttt ata cat acc 96 Gly Ser Pro Met Tyr Phe Phe Leu Ala Ser Leu Ser Phe Ile His Thr 20 25 30 gtc tat tat act gcc att gct ccc aaa atg att gtt gac ctg ctc tct 144 Val Tyr Tyr Thr Ala Ile Ala Pro Lys Met Ile Val Asp Leu Leu Ser 35 40 45 gag aaa aag acc att tct ttt cag ggt tgt atg gct caa ctt ttt atg 192 Glu Lys Lys Thr Ile Ser Phe Gln Gly Cys Met Ala Gln Leu Phe Met 50 55 60 gat cat tta ttt gct ggt gct gaa gtc att ctt ctg gtg gta atg gcc 240 Asp His Leu Phe Ala Gly Ala Glu Val Ile Leu Leu Val Val Met Ala 65 70 75 80 tat gat caa tat gtg gcc atc tgt aag cct ctt cat tat ttg atc atc 288 Tyr Asp Gln Tyr Val Ala Ile Cys Lys Pro Leu His Tyr Leu Ile Ile 85 90 95 atg aat tgt cga gtc tgt gtt ctc atg ctg ttg gtg gcc tgg att gga 336 Met Asn Cys Arg Val Cys Val Leu Met Leu Leu Val Ala Trp Ile Gly 100 105 110 ggc ttt ctt cac tca ttg gtt caa ttt ctc ttt att tat cag ctc cct 384 Gly Phe Leu His Ser Leu Val Gln Phe Leu Phe Ile Tyr Gln Leu Pro 115 120 125 ttc tgt gga ccc aat gtc att gac aac ttc ctg tgt gat ttg tat ccc 432 Phe Cys Gly Pro Asn Val Ile Asp Asn Phe Leu Cys Asp Leu Tyr Pro 130 135 140 tta ttg aaa ctt gct tgc acc aat acc tat gtc act ggg ctt tct atg 480 Leu Leu Lys Leu Ala Cys Thr Asn Thr Tyr Val Thr Gly Leu Ser Met 145 150 155 160 ata gct aat ggt gga gcg att tgt act gtc acc ttc ttc cct ctc ctg 528 Ile Ala Asn Gly Gly Ala Ile Cys Thr Val Thr Phe Phe Pro Leu Leu 165 170 175 ctt tcc tat ggg gtc ata tta ccc tct ctt aag act cag agt ttg gaa 576 Leu Ser Tyr Gly Val Ile Leu Pro Ser Leu Lys Thr Gln Ser Leu Glu 180 185 190 ggg aaa tgc aaa gct ttc tac acc tgt gca tcc cac atc act gtg atc 624 Gly Lys Cys Lys Ala Phe Tyr Thr Cys Ala Ser His Ile Thr Val Ile 195 200 205 act tta ttc ttt gtc ccc tgc atc ttc ctg tta gca agg ccc aac tcc 672 Thr Leu Phe Phe Val Pro Cys Ile Phe Leu Leu Ala Arg Pro Asn Ser 210 215 220 a cc ttt ccc att gat aaa tcc atg act gtg gtt tta act tgt ata act 720 Thr Phe Pro Ile Asp Lys Ser Met Thr Val Val Leu Thr Cys Ile Thr 225 230 235 240 ccc atg ctg aaa cca cta atc tat gcc ctg agg aat gca gaa atg aaa 768 Pro Met Leu Lys Pro Leu Ile Tyr Ala Leu Arg Asn Ala Glu Met Lys 245 250 255 agt gcc atg agg aaa ctt tgg agt gaa aaa gta agc tta gct gga aaa 816 Ser Ala Met Arg Lys Leu Trp Ser Glu Lys Val Ser Leu Ala Gly Lys 260 265 270 ggg ctg tat ccc tca tga 834 Gly Leu Tyr Pro Ser 275 <210> 250 <211> 277 <212> PRT <2 13> Homo sapiens <400> 250 Met Gly Asn Leu Leu Ile Met Val Thr Ile Met Ala Ser Gln Ser Leu 1 5 10 15 Gly Ser Pro Met Tyr Phe Phe Leu Ala Ser Leu Ser Phe Ile His Thr 20 25 30 Val Tyr Tyr Thr Ala Ile Ala Pro Lys Met Ile Val Asp Leu Leu Ser 35 40 45 Glu Lys Lys Thr Ile Ser Phe Gln Gly Cys Met Ala Gln Leu Phe Met 50 55 60 Asp His Leu Phe Ala Gly Ala Glu Val Ile Leu Leu Val Val Met Ala 65 70 75 80 Tyr Asp Gln Tyr Val Ala Ile Cys Lys Pro Leu His Tyr Leu Ile Ile 85 90 95 Met Asn Cys Arg Val Cys Val Leu Met Leu Leu Val Ala Trp Ile Gly 100 105 110 Gly Phe Leu His Ser Leu Val Gln Phe Leu Phe Ile Tyr Gln Leu Pro 115 120 125 Phe Cys Gly Pro Asn Val Ile Asp Asn Phe Leu Cys Asp Leu Tyr Pro 130 135 140 Leu Leu Lys Leu Ala Cys Thr Asn Thr Tyr Val Thr Gly Leu Ser Met 145 150 155 160 Ile Ala Asn Gly Gly Ala Ile Cys Thr Val Thr Phe Phe Pro Leu Leu 165 170 175 Leu Ser Tyr Gly Val Ile Leu Pro Ser Leu Lys Thr Gln Ser Leu Glu 180 185 190 Gly Lys Cys Lys Ala Phe Tyr Thr Cys Ala Ser His Ile Thr Val Ile 195 200 205 Thr Leu Phe Phe Val Pro Cys Ile Phe Leu Leu Ala Arg Pro Asn Ser 210 215 220 Thr Phe Pro Ile Asp Lys Ser Met Thr Val Val Leu Thr Cys Ile Thr 225 230 235 240 Pro Met Leu Lys Pro Leu Ile Tyr Ala Leu Arg Asn Ala Glu Met Lys 245 250 255 Ser Ala Met Arg Lys Leu Trp Ser Glu Lys Val Ser Leu Ala Gly Lys 260 265 270 Gly Leu Tyr Pro Ser 275 <210> 251 <211> 990 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(990) <400> 251 atg caa tta gtt cta tta ctt atg ttt ctc ctt gtc ttt ata ggc aat 48 Met Gln Leu Val Leu Leu Leu Met Phe Leu Leu Val Phe Ile Gly Asn 1 5 10 15 act gca cct gca ttc tca gtg acc ttg gaa tct atg gac ata cca caa 96 Thr Ala Pro Ala Phe Ser Val Thr Leu Glu Ser Met Asp Ile Pro Gln 20 25 30 aat atc aca gaa ttt ttc atg ctg ggg ctc tca cag aac tca gag gta 144 Asn Ile Thr Glu Phe Phe Met Leu Gly Leu Ser Gln Asn Ser Glu Val 35 40 45 cag aga gtt ctc ttt gtg gtc ttt ttg ctg atc tat gtg gtc acg gtt 192 Gln Arg Val Leu Phe Val Val Phe Leu Leu Ile Tyr Val Val Thr Val 50 55 60 tgt ggc aac atg ctc att gtg gtc act atc acc tcc agc ccc acg ctg 240 Cys Gly Asn Met Leu Ile Val Val Thr Ile Thr Ser Ser Pro Thr Leu 65 70 75 80 gct tcc cct gtg tat ttt ttc ctg gcc aac cta tcc ttt att gac acc 288 Ala Ser Pro Val Tyr Phe Phe Leu Ala Asn Leu Ser Phe Ile Asp Thr 85 90 95 ttt tat tct tct tct atg gct cct aaa ctc att gct gac tca ttg tat 336 Phe Tyr Ser Ser Ser Met Ala Pro Lys Leu Ile Ala Asp Ser Leu Tyr 100 105 110 gag ggg aga acc atc tct tat gag tgc tgc atg gct cag ctc ttt gga 384 Glu Gly Arg Thr Ile Ser Tyr Glu Cys Cys Met Ala Gln Leu Phe Gly 115 120 125 gct cat ttt ttg gga ggt gtt gag atc att ctg ctc aca gtg atg gct 432 Ala His Phe Leu Gly Gly Val Glu Ile Ile Leu Leu Thr Val Met Ala 130 135 140 tat gac cgc tat gtg gcc atc tgt aag ccc ctg cac aat act acc atc 480 Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu His Asn Thr Thr Ile 145 150 155 160 atg acc agg cat ctc tgt gcc atg ctt gta ggg gtg gct tgg ctt ggg 528 Met Thr Arg His Leu Cys Ala Met Leu Val Gly Val Ala Trp Leu Gly 165 170 175 ggc ttc ctg cat tca ttg gtt cag ctc ctc ctg gtc ctt tgg ttg ccc 576 Gly Phe Leu His Ser Leu Val Gln Leu Leu Leu Val Leu Trp Leu Pro 180 185 190 ttc tgt ggg ccc aat gtg atc aat cac ttt gcc tgt gac ttg tac cct 624 Phe Cys Gly Pro Asn Val Ile Asn His Phe Ala Cys Asp Leu Tyr Pro 195 200 205 ttg ctg gaa gtt gcc tgc acc aat acg tat gtc att ggt ctg ctg gtg 672 Leu Leu Glu Val Ala Cys Thr Asn Thr Tyr Val Ile Gly Leu Leu Val 210 215 220 gtt gcc aac agt ggt tta atc tgc ctg ttg aac ttc ctc atg ctg gct 720 Val Ala Asn Ser Gly Leu Ile Cys Leu Leu Asn Phe Leu Met Leu Ala 225 230 235 240 gcc tcc tac att gtc atc ctg tac tcc ttg agg tcc cac agt gca gat 768 Ala Ser Tyr Ile Val Ile Leu Tyr Ser Leu Arg Ser His Ser Ala Asp 245 250 255 ggg aga tgc aaa gcc ctc tcc acc tgt gga gcc cac ttc att gtt gtt 816 Gly Arg Cys Lys Ala Leu Ser Thr Cys Gly Ala His Phe Ile Val Val 260 265 270 gcc ttg ttc ttt gtg ccc tgt ata ttt act tat gtg cat cca ttt tct 864 Ala Leu Phe Phe Val Pro Cys Ile Phe Thr Tyr Val His Pro Phe Ser 275 280 285 act tta cct ata gac aaa aat atg gca tta ttt tat ggt att ctg aca 912 Thr Leu Pro Ile Asp Lys Asn Met Ala Leu Phe Tyr Gly Ile Leu Thr 290 295 300 cct atg ttg aat cca ctc att tat acc ctg aga aat gaa gag gta aaa 960 Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn Glu Glu Val Lys 305 310 315 320 aat gcc atg aga aag ctc ttt aca tgg taa 990 Asn Ala Met Arg Lys Leu Phe Thr Trp 325 330 <210> 252 <211> 329 <212> PRT <213> Homo sapiens <400> 252 Met Gln Leu Val Leu Leu Leu Met Phe Leu Leu Val Phe Ile Gly Asn 1 5 10 15 Thr Ala Pro Ala Phe Ser Val Thr Leu Glu Ser Met Asp Ile Pro Gln 20 25 30 Asn Ile Thr Glu Phe Phe Met Leu Gly Leu Ser Gln Asn Ser Glu Val 35 40 45 Gln Arg Val Leu Phe Val Val Phe Leu Leu Ile Tyr Val Val Thr Val 50 55 60 Cys Gly Asn Met Leu Ile Val Val Thr Ile Thr Ser Ser Pro Thr Leu 65 70 75 80 Ala Ser Pro Val Tyr Phe Phe Leu Ala Asn Leu Ser Phe Ile Asp Thr 85 90 95 Phe Tyr Ser Ser Ser Met Ala Pro Lys Leu Ile Ala Asp Ser Leu Tyr 100 105 110 Glu Gly Arg Thr Ile Ser Tyr Glu Cys Cys Met Ala Gln Leu Phe Gly 115 120 125 Ala His Phe Leu Gly Gly Val Glu Ile Ile Leu Leu Thr Val Met Ala 130 135 140 Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu His Asn Thr Thr Ile 145 150 155 160 Met Thr Arg His Leu Cys Ala Met Leu Val Gly Val Ala Trp Leu Gly 165 170 175 Gly Phe Leu His Ser Leu Val Gln Leu Leu Leu Val Leu Trp Leu Pro 180 185 190 Phe Cys Gly Pro Asn Val Ile Asn His Phe Ala Cys Asp Leu Tyr Pro 195 200 205 Leu Leu Glu Val Ala Cys Thr Asn Thr Tyr Val Ile Gly Leu Leu Val 210 215 220 Val Ala Asn Ser Gly Leu Ile Cys Leu Leu Asn Phe Leu Met Leu Ala 225 230 235 240 Ala Ser Tyr Ile Val Ile Leu Tyr Ser Leu Arg Ser His Ser Ala Asp 245 250 255 Gly Arg Cys Lys Ala Leu Ser Thr Cys Gly Ala His Phe Ile Val Val 260 265 270 Ala Leu Phe Phe Val Pro Cys Ile Phe Thr Tyr Val His Pro Phe Ser 275 280 285 Thr Leu Pro Ile Asp Lys Asn Met Ala Leu Phe Tyr Gly Ile Leu Thr 290 295 300 Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn Glu Glu Val Lys 305 310 315 320 Asn Ala Met Arg Lys Leu Phe Thr Trp 325 <210> 253 <211> 930 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(930) <400> 253 atg ggt gcc aag aac aat gtg act gag ttt gtt tta ttt ggc ctt ttt 48 Met Gly Ala Lys Asn Asn Val Thr Glu Phe Val Leu Phe Gly Leu Phe 1 5 10 15 gag agc aga gag atg cag cat aca tgc ttt gtg gta ttc ttc ctc ttt 96 Glu Ser Arg Glu Met Gln His Thr Cys Phe Val Val Phe Phe Leu Phe 20 25 30 cat gtg ctc act gtc ctg ggg aac ctt ctg gtc atc atc acc atc aat 144 His Val Leu Thr Val Leu Gly Asn Leu Leu Val Ile Ile Thr Ile Asn 35 40 45 gct aga aag acc ctg aag tct ccc atg tat ttc ttc ctg agc cag ttg 192 Ala Arg Lys Thr Leu Lys Ser Pro Met Tyr Phe Phe Leu Ser Gln Leu 50 55 60 tct ttt gct gac ata tgt tat cca tcc act acc ata ccc aag atg att 240 Ser Phe Ala Asp Ile Cys Tyr Pro Ser Thr Thr Ile Pro Lys Met Ile 65 70 75 80 gct gac act ttt gtg gag cat aag atc atc tcc ttc aat ggc tgc atg 288 Ala Asp Thr Phe Val Glu His Lys Ile Ile Ser Phe Asn Gly Cys Met 85 90 95 acc cag ctc ttt tct gcc cac ttc ttt ggt ggc act gag atc ttc ctc 336 Thr Gln Leu Phe Ser Ala His Phe Phe Gly Gly Thr Glu Ile Phe Leu 100 105 110 ctt aca gcc atg gcc tat gac cgc tat gtg gcc atc tgt agg ccc ctg 384 Leu Thr Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Arg Pro Leu 115 120 125 cac tac aca gcc atc atg gat tgc cgg aag tgt ggc ctg cta gcg ggg 432 His Tyr Thr Ala Ile Met Asp Cys Arg Lys Cys Gly Leu Leu Ala Gly 130 135 140 gcc tcc tgg tta gct ggc ttc ctg cat tcc atc ctg cag acc ctc ctc 480 Ala Ser Trp Leu Ala Gly Phe Leu His Ser Ile Leu Gln Thr Leu Leu 145 150 155 160 acg gtt cag ctg cct ttt tgt ggg ccc aat gag ata gac aac ttc ttc 528 Thr Val Gln Leu Pro Phe Cys Gly Pro Asn Glu Ile Asp Asn Phe Phe 165 170 175 tgt gat gtt cat ccc ctg ctc aag ttg gcc tgt gca gac acc tac atg 576 Cys Asp Val His Pro Leu Leu Lys Leu Ala Cys Ala Asp Thr Tyr Met 180 185 190 gta ggt ctc atc gtg gtg gcc aac agc ggt atg att tct tta gca tcc 624 Val Gly Leu Ile Val Val Ala Asn Ser Gly Met Ile Ser Leu Ala Ser 195 200 205 ttt ttt atc ctt atc att tcc tat gtt atc atc tta ctg aac cta aga 672 Phe Phe Ile Leu Ile Ile Ser Tyr Val Ile Ile Leu Leu Asn Leu Arg 210 215 220 agc cag tca tct gag gac cgg cgt aag gct gtc tcc aca tgt ggc tca 720 Ser Gln Ser Ser Glu Asp Arg Arg Lys Ala Val Ser Thr Cys Gly Ser 225 230 235 240 cac gta atc act gtc ctt ttg gtt ctc atg ccc ccc atg ttc atg tac 768 His Val Ile Thr Val Leu Leu Val Leu Met Pro Pro Met Phe Met Tyr 245 250 255 att cgt ccc tcc acc acc ctg gct gct gac aaa ctt atc atc ctc ttt 816 Ile Arg Pro Ser Thr Thr Leu Ala Ala Asp Lys Leu Ile Ile Leu Phe 260 265 270 aac att gtg atg cca cct ttg ctg aac cct ttg atc tat aca cta agg 864 Asn Ile Val Met Pro Pro Leu Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 aac aac gat gtg aaa aat gcc atg agg aag ctg ttt agg gtc aag agg 912 Asn Asn Asp Val Lys Asn Ala Met Arg Lys Leu Phe Arg Val Lys Arg 290 295 300 agc tta ggg gag aag tga 930 Ser Leu Gly Glu Lys 305 310 <210> 254 <211> 309 <212> PRT <213> Homo sapiens <400> 254 Met Gly Ala Lys Asn Asn Val Thr Glu Phe Val Leu Phe Gly Leu Phe 1 5 10 15 Glu Ser Arg Glu Met Gln His Thr Cys Phe Val Val Phe Phe Leu Phe 20 25 30 His Val Leu Thr Val Leu Gly Asn Leu Leu Val Ile Ile Thr Ile Asn 35 40 45 Ala Arg Lys Thr Leu Lys Ser Pro Met Tyr Phe Phe Leu Ser Gln Leu 50 55 60 Ser Phe Ala Asp Ile Cys Tyr Pro Ser Thr Thr Ile Pro Lys Met Ile 65 70 75 80 Ala Asp Thr Phe Val Glu His Lys Ile Ile Ser Phe Asn Gly Cys Met 85 90 95 Thr Gln Leu Phe Ser Ala His Phe Phe Gly Gly Thr Glu Ile Phe Leu 100 105 110 Leu Thr Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Arg Pro Leu 115 120 125 His Tyr Thr Ala Ile Met Asp Cys Arg Lys Cys Gly Leu Leu Ala Gly 130 135 140 Ala Ser Trp Leu Ala Gly Phe Leu His Ser Ile Leu Gln Thr Leu Leu 145 150 155 160 Thr Val Gln Leu Pro Phe Cys Gly Pro Asn Glu Ile Asp Asn Phe Phe 165 170 175 Cys Asp Val His Pro Leu Leu Lys Leu Ala Cys Ala Asp Thr Tyr Met 180 185 190 Val Gly Leu Ile Val Val Ala Asn Ser Gly Met Ile Ser Leu Ala Ser 195 200 205 Phe Phe Ile Leu Ile Ile Ser Tyr Val Ile Ile Leu Leu Asn Leu Arg 210 215 220 Ser Gln Ser Ser Glu Asp Arg Arg Lys Ala Val Ser Thr Cys Gly Ser 225 230 235 240 His Val Ile Thr Val Leu Leu Val Leu Met Pro Pro Met Phe Met Tyr 245 250 255 Ile Arg Pro Ser Thr Thr Leu Ala Ala Asp Lys Leu Ile Ile Leu Phe 260 265 270 Asn Ile Val Met Pro Pro Leu Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Asn Asp Val Lys Asn Ala Met Arg Lys Leu Phe Arg Val Lys Arg 290 295 300 Ser Leu Gly Glu Lys 305 <210> 255 <211> 1080 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1080) <400> 255 atg aat aac ata gct caa ctt agt ctt ggg ttt ata gat tta ggg att 48 Met Asn Asn Ile Ala Gln Leu Ser Leu Gly Phe Ile Asp Leu Gly Ile 1 5 10 15 cca tca gtg tta cag aaa ata atc ctg acc aaa att att tta ttg ttc 96 Pro Ser Val Leu Gln Lys Ile Ile Leu Thr Lys Ile Ile Leu Leu Phe 20 25 30 aaa atg tat gtg tca aat tgc aat cct tgt gct att cac aga aaa atc 144 Lys Met Tyr Val Ser Asn Cys Asn Pro Cys Ala Ile His Arg Lys Ile 35 40 45 aat tat cca aat acc aaa ctg gat ttc gag caa gtg aac aac ata acg 192 Asn Tyr Pro Asn Thr Lys Leu Asp Phe Glu Gln Val Asn Asn Ile Thr 50 55 60 gaa ttc atc ttg ctt ggc ctg aca cag aac gca gag gca cag aaa ctc 240 Glu Phe Ile Leu Leu Gly Leu Thr Gln Asn Ala Glu Ala Gln Lys Leu 65 70 75 80 ttg ttt gct gtg ttt aca ctc atc tac ttt ctc acc atg gta gac aac 288 Leu Phe Ala Val Phe Thr Leu Ile Tyr Phe Leu Thr Met Val Asp Asn 85 90 95 cta atc att gtg gtg aca atc acc acc agc cca gcc ctg gac tcc ccc 336 Leu Ile Ile Val Val Thr Ile Thr Thr Ser Pro Ala Leu Asp Ser Pro 100 105 110 gtg tat ttt ttt ctg tct ttc ttt tcc ttc ata gat ggc tgc tcc tct 384 Val Tyr Phe Phe Leu Ser Phe Phe Ser Phe Ile Asp Gly Cys Ser Ser 115 120 125 tct acc atg gcc ccc aaa atg ata ttt gac tta ctc act gaa aag aaa 432 Ser Thr Met Ala Pro Lys Met Ile Phe Asp Leu Leu Thr Glu Lys Lys 130 135 140 act att tcc ttc agt ggg tgc atg acc cag ctc ttt gta gaa cat ttc 480 Thr Ile Ser Phe Ser Gly Cys Met Thr Gln Leu Phe Val Glu His Phe 145 150 155 160 ttt ggg gga gtt gag atc att ctg ctc gtg gtg atg gcc tat gac tgc 528 Phe Gly Gly Val Glu Ile Ile Leu Leu Val Val Met Ala Tyr Asp Cys 165 170 175 tat gtg gcc atc tgc aag ccc ctg tac tac ctg atc aca atg aac agg 576 Tyr Val Ala Ile Cys Lys Pro Leu Tyr Tyr Leu Ile Thr Met Asn Arg 180 185 190 cag gta tgt ggc ctc ctg gtg gcc atg gca tgg gtc ggg gga ttt ctt 624 Gln Val Cys Gly Leu Leu Val Ala Met Ala Trp Val Gly Gly Phe Leu 195 200 205 cac gct ctg att caa atg ctt tta ata gtc tgg ctg ccc ttc tgt ggc 672 His Ala Leu Ile Gln Met Leu Leu Ile Val Trp Leu Pro Phe Cys Gly 210 215 220 ccc aat gtc att gac cat ttc atc tgt gac ctt ttc cct ctg cta aaa 720 Pro Asn Val Ile Asp His Phe Ile Cys Asp Leu Phe Pro Leu Leu Lys 225 230 235 240 ctc tcc tgc act gac act cac gtc ttt gga ctc ttt gtt gcc gcc aac 768 Leu Ser Cys Thr Asp Thr His Val Phe Gly Leu Phe Val Ala Ala Asn 245 250 255 agt ggg ctg atg tgt atg ctc att ttt tct att ctt att acc tct tac 816 Ser Gly Leu Met Cys Met Leu Ile Phe Ser Ile Leu Ile Thr Ser Tyr 260 265 270 gtc cta atc ctc tgc tca cag cgg aag gct ctc tct acc tgc gcc ttc 864 Val Leu Ile Leu Cys Ser Gln Arg Lys Ala Leu Ser Thr Cys Ala Phe 275 280 285 cat atc act gta gtc gtc cta ttc ttt gtt ccc tgt ata ttg gtg tac 912 His Ile Thr Val Val Val Leu Phe Phe Val Pro Cys Ile Leu Val Tyr 290 295 300 ctt cga ccc atg atc acc ttc cct att gat aaa gct gtg tct gtg ttt 960 Leu Arg Pro Met Ile Thr Phe Pro Ile Asp Lys Ala Val Ser Val Phe 305 310 315 320 tat act gtg gta aca ccc atg tta aac cct tta atc tac acc ctc aga 1008 Tyr Thr Val Val Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 325 330 335 aac aca gag gtg aaa aat gcc atg aag cag ctc tgg agc caa ata atc 1056 Asn Thr Glu Val Lys Asn Ala Met Lys Gln Leu Trp Ser Gln Ile Ile 340 345 350 tgg ggt aac aat ttg tgt gat tag 1080 Trp Gly Asn Asn Leu Cys Asp 355 360 <210> 256 <211> 359 <212> PRT <213> Homo sapiens <400> 256 Met Asn Asn Ile Ala Gln Leu Ser Leu Gly Phe Ile Asp Leu Gly Ile 1 5 10 15 Pro Ser Val Leu Gln Lys Ile Ile Leu Thr Lys Ile Ile Leu Leu Phe 20 25 30 Lys Met Tyr Val Ser Asn Cys Asn Pro Cys Ala Ile His Arg Lys Ile 35 40 45 Asn Tyr Pro Asn Thr Lys Leu Asp Phe Glu Gln Val Asn Asn Ile Thr 50 55 60 Glu Phe Ile Leu Leu Gly Leu Thr Gln Asn Ala Glu Ala Gln Lys Leu 65 70 75 80 Leu Phe Ala Val Phe Thr Leu Ile Tyr Phe Leu Thr Met Val Asp Asn 85 90 95 Leu Ile Ile Val Val Thr Ile Thr Thr Ser Pro Ala Leu Asp Ser Pro 100 105 110 Val Tyr Phe Phe Leu Ser Phe Phe Ser Phe Ile Asp Gly Cys Ser Ser 115 120 125 Ser Thr Met Ala Pro Lys Met Ile Phe Asp Leu Leu Thr Glu Lys Lys 130 135 140 Thr Ile Ser Phe Ser Gly Cys Met Thr Gln Leu Phe Val Glu His Phe 145 150 155 160 Phe Gly Gly Val Glu Ile Ile Leu Leu Val Val Met Ala Tyr Asp Cys 165 170 175 Tyr Val Ala Ile Cys Lys Pro Leu Tyr Tyr Leu Ile Thr Met Asn Arg 180 185 190 Gln Val Cys Gly Leu Leu Val Ala Met Ala Trp Val Gly Gly Phe Leu 195 200 205 His Ala Leu Ile Gln Met Leu Leu Ile Val Trp Leu Pro Phe Cys Gly 210 215 220 Pro Asn Val Ile Asp His Phe Ile Cys Asp Leu Phe Pro Leu Leu Lys 225 230 235 240 Leu Ser Cys Thr Asp Thr His Val Phe Gly Leu Phe Val Ala Ala Asn 245 250 255 Ser Gly Leu Met Cys Met Leu Ile Phe Ser Ile Leu Ile Thr Ser Tyr 260 265 270 Val Leu Ile Leu Cys Ser Gln Arg Lys Ala Leu Ser Thr Cys Ala Phe 275 280 285 His Ile Thr Val Val Val Leu Phe Phe Val Pro Cys Ile Leu Val Tyr 290 295 300 Leu Arg Pro Met Ile Thr Phe Pro Ile Asp Lys Ala Val Ser Val Phe 305 310 315 320 Tyr Thr Val Val Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 325 330 335 Asn Thr Glu Val Lys Asn Ala Met Lys Gln Leu Trp Ser Gln Ile Ile 340 345 350 Trp Gly Asn Asn Leu Cys Asp 355 <210> 257 <211> 930 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(930) <400> 257 atg gaa aat caa aac aat gtg act gaa ttc att ctt ctg ggt ctc aca 48 Met Glu Asn Gln Asn Asn Val Thr Glu Phe Ile Leu Leu Gly Leu Thr 1 5 10 15 gag aac ctg gag ctg tgg aaa ata ttt tct gct gtg ttt ctt gtc atg 96 Glu Asn Leu Glu Leu Trp Lys Ile Phe Ser Ala Val Phe Leu Val Met 20 25 30 tat gta gcc aca gtg ctg gaa aat cta ctt att gtg gta act att atc 144 Tyr Val Ala Thr Val Leu Glu Asn Leu Leu Ile Val Val Thr Ile Ile 35 40 45 aca agt cag agt ctg agg tca cct atg tat ttt ttt ctt acc ttc ttg 192 Thr Ser Gln Ser Leu Arg Ser Pro Met Tyr Phe Phe Leu Thr Phe Leu 50 55 60 tcc ctt ttg gat gtc atg ttc tca tct gtc gtt gcc ccc aag gtg att 240 Ser Leu Leu Asp Val Met Phe Ser Ser Val Val Ala Pro Lys Val Ile 65 70 75 80 gta gac acc ctc tcc aag agc act acc atc tct ctc aaa ggc tgc ctc 288 Val Asp Thr Leu Ser Lys Ser Thr Thr Ile Ser Leu Lys Gly Cys Leu 85 90 95 acc cag ctg ttt gtg gag cat ttc ttt ggt ggt gtg ggg atc atc ctc 336 Thr Gln Leu Phe Val Glu His Phe Phe Gly Gly Val Gly Ile Ile Leu 100 105 110 ctc act gtg atg gcc tat gac cgc tac gtg gcc atc tgt aag ccc ctg 384 Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 cac tac acg atc atc atg agt cca cgg gtg tgc tgc cta atg gta gga 432 His Tyr Thr Ile Ile Met Ser Pro Arg Val Cys Cys Leu Met Val Gly 130 135 140 ggg gct tgg gtg ggg gga ttt atg cac gca atg ata caa ctt ctc ttc 480 Gly Ala Trp Val Gly Gly Phe Met His Ala Met Ile Gln Leu Leu Phe 145 150 155 160 atg tat caa ata ccc ttc tgt ggt cct aat atc ata gat cac ttt ata 528 Met Tyr Gln Ile Pro Phe Cys Gly Pro Asn Ile Ile Asp His Phe Ile 165 170 175 tgt gat ttg ttt cag ttg ttg aca ctt gcc tgc acg gac acc cac atc 576 Cys Asp Leu Phe Gln Leu Leu Thr Leu Ala Cys Thr Asp Thr His Ile 180 185 190 ctg ggc ctc tta gtt acc ctc aac agt ggg atg atg tgt gtg gcc atc 624 Leu Gly Leu Leu Val Thr Leu Asn Ser Gly Met Met Cys Val Ala Ile 195 200 205 ttt ctt atc tta att gcg tcc tac acg gtc atc cta tgc tcc ctg aag 672 Phe Leu Ile Leu Ile Ala Ser Tyr Thr Val Ile Leu Cys Ser Leu Lys 210 215 220 tct tac agc tct aaa ggg cgg cac aaa gcc ctc tct acc tgc agc tcc 720 Ser Tyr Ser Ser Lys Gly Arg His Lys Ala Leu Ser Thr Cys Ser Ser 225 230 235 240 cac ctc acg gtg gtt gta ttg ttc ttt gtc ccc tgt att ttc ttg tac 768 His Leu Thr Val Val Val Leu Phe Phe Val Pro Cys Ile Phe Leu Tyr 245 250 255 atg agg cct gtg gtc act cac ccc ata gac aag gca atg gct gtg tca 816 Met Arg Pro Val Val Thr His Pro Ile Asp Lys Ala Met Ala Val Ser 260 265 270 gac tca atc atc aca ccc atg tta aat ccc ttg atc tat aca ctg agg 864 Asp Ser Ile Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 aat gca gag gtg aaa agt gcc atg aag aaa ctc tgg atg aaa tgg gag 912 Asn Ala Glu Val Lys Ser Ala Met Lys Lys Leu Trp Met Lys Trp Glu 290 295 300 gct ttg gct ggg aaa taa 930 Ala Leu Ala Gly Lys 305 310 <210> 258 <211> 309 <212> PRT <213> Homo sapiens <400> 258 Met Glu Asn Gln Asn Asn Val Thr Glu Phe Ile Leu Leu Gly Leu Thr 1 5 10 15 Glu Asn Leu Glu Leu Trp Lys Ile Phe Ser Ala Val Phe Leu Val Met 20 25 30 Tyr Val Ala Thr Val Leu Glu Asn Leu Leu Ile Val Val Thr Ile Ile 35 40 45 Thr Ser Gln Ser Leu Arg Ser Pro Met Tyr Phe Phe Leu Thr Phe Leu 50 55 60 Ser Leu Leu Asp Val Met Phe Ser Ser Val Val Ala Pro Lys Val Ile 65 70 75 80 Val Asp Thr Leu Ser Lys Ser Thr Thr Ile Ser Leu Lys Gly Cys Leu 85 90 95 Thr Gln Leu Phe Val Glu His Phe Phe Gly Gly Val Gly Ile Ile Leu 100 105 110 Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Thr Ile Ile Met Ser Pro Arg Val Cys Cys Leu Met Val Gly 130 135 140 Gly Ala Trp Val Gly Gly Phe Met His Ala Met Ile Gln Leu Leu Phe 145 150 155 160 Met Tyr Gln Ile Pro Phe Cys Gly Pro Asn Ile Ile Asp His Phe Ile 165 170 175 Cys Asp Leu Phe Gln Leu Leu Thr Leu Ala Cys Thr Asp Thr His Ile 180 185 190 Leu Gly Leu Leu Val Thr Leu Asn Ser Gly Met Met Cys Val Ala Ile 195 200 205 Phe Leu Ile Leu Ile Ala Ser Tyr Thr Val Ile Leu Cys Ser Leu Lys 210 215 220 Ser Tyr Ser Ser Lys Gly Arg His Lys Ala Leu Ser Thr Cys Ser Ser 225 230 235 240 His Leu Thr Val Val Val Leu Phe Phe Val Pro Cys Ile Phe Leu Tyr 245 250 255 Met Arg Pro Val Val Thr His Pro Ile Asp Lys Ala Met Ala Val Ser 260 265 270 As p Ser Ile Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ala Glu Val Lys Ser Ala Met Lys Lys Leu Trp Met Lys Trp Glu 290 295 300 Ala Leu Ala Gly Lys 305 <210> 259 <211> 936 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(936) <400> 259 atg ggc aag gaa aac tgc acc act gtg gct gag ttc att ctc ctt gga 48 Met Gly Lys Glu Asn Cys Thr Thr Val Ala Glu Phe Ile Leu Leu Gly 1 5 10 15 cta tca gat gtc cct gag ttg aga gtc tgc ctc ttc ctg ctg ttc ctt 96 L eu Ser Asp Val Pro Glu Leu Arg Val Cys Leu Phe Leu Leu Phe Leu 20 25 30 ctc atc tat gga gtc acg ttg tta gcc aac ctg ggc atg att gca ctg 144 Leu Ile Tyr Gly Val Thr Leu Leu Ala Asn Leu Gly Met Ile Ala Leu 35 40 45 att cag gtc agc tct cgg ctc cac acc ccc atg tac ttt ttc ctc agc 192 Ile Gln Val Ser Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 cac ttg tcc tct gta gat ttc tgc tac tcc tca ata att gtg cca aaa 240 His Leu Ser Ser Val Asp Phe Cys Tyr Ser Ser Ile Ile Val Pro Lys 65 70 75 80 atg ttg gct aat atc ttt aac aag gac aaa gcc atc tcc ttc cta ggg 288 Met Leu Ala Asn Ile Phe Asn Lys Asp Lys Ala Ile Ser Phe Leu Gly 85 90 95 tgc atg gtg caa ttc tac ttg ttt tgc act tgt gtg gtc act gag gtc 336 Cys Met Val Gln Phe Tyr Leu Phe Cys Thr Cys Val Val Thr Glu Val 100 105 110 ttc ctg ctg gcc gtg atg gcc tat gac cgc ttt gtg gcc atc tgt aac 384 Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys Asn 115 120 125 cct ttg cta tac aca gtc acc atg tct tgg aag gtg cgt gtg gag ctg 432 Pro Leu Leu Tyr Thr Val Thr Met Ser Trp Lys Val Arg Val Glu Leu 130 135 140 gct tct tgc tgc tac ttc tgt ggg acg gtg tgt tct ctg att cat ttg 480 Ala Ser Cys Cys Tyr Phe Cys Gly Thr Val Cys Ser Leu Ile His Leu 145 150 155 160 tgc tta gct ctt agg atc ccc ttc tat aga tct aat gtg att aac cac 528 Cys Leu Ala Leu Arg Ile Pro Phe Tyr Arg Ser Asn Val Ile Asn His 165 170 175 ttt ttc tgt gat cta cct cct gtc tta agt ctt gct tgc tct gat atc 576 Phe Phe Cys Asp Leu Pro Pro Val Leu Ser Leu Ala Cys Ser Asp Ile 180 185 190 act gtg aat gag aca ctg ctg ttc ctg gtg gcc act ttg aat gag agt 624 Thr Val Asn Glu Thr Leu Leu Phe Leu Val Ala Thr Leu Asn Glu Ser 195 200 205 gtt acc atc atg atc atc ctc acc tcc tac ctg cta att ctc acc acc 672 Val Thr Ile Met Ile Ile Leu Thr Ser Tyr Leu Leu Ile Leu Thr Thr 210 215 220 atc ctg aag atg ggc tct gca gag ggc agg cac aaa gcc ttc tcc acc 720 Ile Leu Lys Met Gly Ser Ala Glu Gly Arg His Lys Ala Phe Ser Thr 225 230 235 240 tgt gct tcc cac ctc aca gct atc act gtc ttc cat gga aca gtc ctt 768 Cys Ala Ser His Leu Thr Ala Ile Thr Val Phe His Gly Thr Val Leu 245 250 255 tcc att tat tgc agg ccc agt tca ggc aat agt gga gat gct gac aaa 816 Ser Ile Tyr Cys Arg Pro Ser Ser Gly Asn Ser Gly Asp Ala Asp Lys 260 265 270 gtg gcc acc gtg ttc tac aca gtc gtg att cct atg ctg aac tct gtg 864 Val Ala Thr Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Ser Val 275 280 285 atc tac agc ctg aga aat aaa gat gtg aaa gaa gct ctc aga aaa gtg 912 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu Ala Leu Arg Lys Val 290 295 300 atg ggc tcc aaa att cac tcc tag 936 Met Gly Ser Lys Ile His Ser 305 310 <210> 260 <211> 311 <212> PRT <213> Homo sapiens <400> 260 Met Gly Lys Glu Asn Cys Thr Thr Val Ala Glu Phe Ile Leu Leu Gly 1 5 10 15 Leu Ser Asp Val Pro Glu Leu Arg Val Cys Leu Phe Leu Leu Phe Leu 20 25 30 Leu Ile Tyr Gly Val Thr Leu Leu Ala Asn Leu Gly Met Ile Ala Leu 35 40 45 Ile Gln Val Ser Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 His Leu Ser Ser Val Asp Phe Cys Tyr Ser Ser Ile Ile Val Pro Lys 65 70 75 80 Met Leu Ala Asn Ile Phe Asn Lys Asp Lys Ala Ile Ser Phe Leu Gly 85 90 95 Cys Met Val Gln Phe Tyr Leu Phe Cys Thr Cys Val Val Thr Glu Val 100 105 110 Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Thr Val Thr Met Ser Trp Lys Val Arg Val Glu Leu 130 135 140 Ala Ser Cys Cys Tyr Phe Cys Gly Thr Val Cys Ser Leu Ile His Leu 145 150 155 160 Cys Leu Ala Leu Arg Ile Pro Phe Tyr Arg Ser Asn Val Ile Asn His 165 170 175 Phe Phe Cys Asp Leu Pro Pro Val Leu Ser Leu Ala Cys Ser Asp Ile 180 185 190 Thr Val Asn Glu Thr Leu Leu Phe Leu Val Ala Thr Leu Asn Glu Ser 195 200 205 Val Thr Ile Met Ile Ile Leu Thr Ser Tyr Leu Leu Ile Leu Thr Thr 210 215 220 Ile Leu Lys Met Gly Ser Ala Glu Gly Arg His Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Thr Ala Ile Thr Val Phe His Gly Thr Val Leu 245 250 255 Ser Ile Tyr Cys Arg Pro Ser Ser Gly Asn Ser Gly Asp Ala Asp Lys 260 265 270 Val Ala Thr Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Ser Val 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu Ala Leu Arg Lys Val 290 295 300 Met Gly Ser Lys Ile His Ser 305 310 <210> 261 <211> 945 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(945) <400> 261 atg atg gca tct gaa aga aat caa agc agc aca ccc act ttt att ctc 48 Met Met Ala Ser Glu Arg Asn Gln Ser Ser Thr Pro Thr Phe Ile Leu 1 5 10 15 ttg ggt ttt tca gaa tac cca gaa atc cag gtt cca ctc ttt ctg gtt 96 Leu Gly Phe Ser Glu Tyr Pro Glu Ile Gln Val Pro Leu Phe Leu Val 20 25 30 t tc ttg ttc gtc tac aca gtc act gta gtg ggg aac ttg ggc atg ata 144 Phe Leu Phe Val Tyr Thr Val Thr Val Val Gly Asn Leu Gly Met Ile 35 40 45 ata atc atc aga ctc aat tca aaa ctc cat aca atc atg tgc ttt ttc 192 Ile Ile Ile Arg Leu Asn Ser Lys Leu His Thr Ile Met Cys Phe Phe 50 55 60 ctt agt cac ttg tcc ttg aca gac ttc tgt ttt tcc act gta gtt aca 240 Leu Ser His Leu Ser Leu Thr Asp Phe Cys Phe Ser Thr Val Val Thr 65 70 75 80 cct aaa ctg ttg gag aac ttg gtt gtg gaa tac aga acc atc tct ttc 288 Pro Lys Leu Leu Glu Asn Leu Val Val Glu Tyr Arg Thr Ile Ser Phe 85 90 95 tct ggt tgc atc atg caa ttt tgt ttt gct tgc att ttt gga gtg aca 336 Ser Gly Cys Ile Met Gln Phe Cys Phe Ala Cys Ile Phe Gly Val Thr 100 105 110 gaa act ttc atg tta gca gcg atg gct tat gac cgt ttt gtg gca gtt 384 Glu Thr Phe Met Leu Ala Ala Met Ala Tyr Asp Arg Phe Val Ala Val 115 120 125 tgt aaa ccc ttg ctg tat acc act att atg tct cag aag ctc tgt gct 432 Cys Lys Pro Leu Leu Tyr Thr Thr Ile Met Ser Gln Lys Leu Cys Ala 130 135 140 ctt ctg gtg gct ggg tcc tat aca tgg ggg ata gtg tgc tcc ctg ata 480 Leu Leu Val Ala Gly Ser Tyr Thr Trp Gly Ile Val Cys Ser Leu Ile 145 150 155 160 ctc aca tat ttt ctt ctt gac tta tcg ttt tgt gaa tct acc ttc ata 528 Leu Thr Tyr Phe Leu Leu Asp Leu Ser Phe Cys Glu Ser Thr Phe Ile 165 170 175 aat aat ttt atc tgt gac cac tct gta att gtt tct gcc tcc tac tca 576 Asn Asn Phe Ile Cys Asp His Ser Val Ile Val Ser Ala Ser Tyr Ser 180 185 190 gac ccc tat atc agc cag agg cta tgc ttt att att gcc ata ttc aat 624 Asp Pro Tyr Ile Ser Gln Arg Leu Cys Phe Ile Ile Ala Ile Phe Asn 195 200 205 gag gtg agc agc cta att atc att ctg aca tca tat atg ctt att ttc 672 Glu Val Ser Ser Leu Ile Ile Ile Leu Thr Ser Tyr Met Leu Ile Phe 210 215 220 act acc att atg aag atg cga tct gca agt ggg cgc cag aaa act ttc 720 Thr Thr Ile Met Lys Met Arg Ser Ala Ser Gly Arg Gln Lys Thr Phe 225 230 235 240 tcc acc tgt gcc tcc cac ctg aca gcc atc act atc ttc cat gga act 768 Ser Thr Cys Ala Ser His Leu Thr Ala Ile Thr Ile Phe His Gly Thr 245 250 255 atc ctt ttc ctt tac tgt gtt cct aat cct aaa act tct agc ctc ata 816 Ile Leu Phe Leu Tyr Cys Val Pro Asn Pro Lys Thr Ser Ser Leu Ile 260 265 270 gtt aca gtg gct tct gtg ttt tac aca gtg gcg att cca atg ctg aac 864 Val Thr Val Ala Ser Val Phe Tyr Thr Val Ala Ile Pro Met Leu Asn 275 280 285 cca ttg atc tac agc ctt agg aac aaa gat atc aat aac atg ttt gaa 912 Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Ile Asn Asn Met Phe Glu 290 295 300 aaa tta gtt gtc acc aaa ttg att tac cac tga 945 Lys Leu Val Val Thr Lys Leu Ile Tyr His 305 310 315 <210> 262 <211> 314 <212> PRT <213> Homo sapiens <400> 262 Met Met Ala Ser Glu Arg Asn Gln Ser Ser Thr Pro Thr Phe Ile Leu 1 5 10 15 Leu Gly Phe Ser Glu Tyr Pro Glu Ile Gln Val Pro Leu Phe Leu Val 20 25 30 Phe Leu Phe Val Tyr Thr Val Thr Val Val Gly Asn Leu Gly Met Ile 35 40 45 Ile Ile Ile Arg Leu Asn Ser Lys Leu His Thr Ile Met Cys Phe Phe 50 55 60 Leu Ser His Leu Ser Leu Thr Asp Phe Cys Phe Ser Thr Val Val Thr 65 70 75 80 Pro Lys Leu Leu Glu Asn Leu Val Val Glu Tyr Arg Thr Ile Ser Phe 85 90 95 Ser Gly Cys Ile Met Gln Phe Cys Phe Ala Cys Ile Phe Gly Val Thr 100 105 110 Glu Thr Phe Met Leu Ala Ala Met Ala Tyr Asp Arg Phe Val Ala Val 115 120 125 Cys Lys Pro Leu Leu Tyr Thr Thr Ile Met Ser Gln Lys Leu Cys Ala 130 135 140 Leu Leu Val Ala Gly Ser Tyr Thr Trp Gly Ile Val Cys Ser Leu Ile 145 150 155 160 Leu Thr Tyr Phe Leu Leu Asp Leu Ser Phe Cys Glu Ser Thr Phe Ile 165 170 175 Asn Asn Phe Ile Cys Asp His Ser Val Ile Val Ser Ala Ser Tyr Ser 180 185 190 Asp Pro Tyr Ile Ser Gln Arg Leu Cys Phe Ile Ile Ala Ile Phe Asn 195 200 205 Glu Val Ser Ser Leu Ile Ile Ile Leu Thr Ser Tyr Met Leu Ile Phe 210 215 220 Thr Thr Ile Met Lys Met Arg Ser Ala Ser Gly Arg Gln Lys Thr Phe 225 230 235 240 Ser Thr Cys Ala Ser His Leu Thr Ala Ile Thr Ile Phe His Gly Thr 245 250 255 Ile Leu Phe Leu Tyr Cys Val Pro Asn Pro Lys Thr Ser Ser Leu Ile 260 265 270 Val Thr Val Ala Ser Val Phe Tyr Thr Val Ala Ile Pro Met Leu Asn 275 280 285 Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Ile Asn Asn Met Phe Glu 290 295 300 Lys Leu Val Val Thr Lys Leu Ile Tyr His 305 310 <210> 263 <211> 945 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(945) <400> 263 atg atg atg gtt tta agg aat ctg agc atg gag ccc acc ttt gcc ctt 48 Met Met Met Val Leu Arg Asn Leu Ser Met Glu Pro Thr Phe Ala Leu 1 5 10 15 tta ggt ttc aca gat tac cca aag ctt cag att cct ctc ttc ctt gtg 96 Leu Gly Phe Thr Asp Tyr Pro Lys Leu Gln Ile Pro Leu Phe Leu Val 20 25 30 ttt ctg ctc atg tat gtt atc aca gtg gta gga aac ctt ggg atg atc 144 Phe Leu Leu Met Tyr Val Ile Thr Val Val Gly Asn Leu Gly Met Ile 35 40 45 ata ata atc aag att aac ccc aaa ttt cac act cct atg tac ttt ttc 192 Ile Ile Ile Lys Ile Asn Pro Lys Phe His Thr Pro Met Tyr Phe Phe 50 55 60 ctt agt cac ctc tct ttt gtt gat ttt tgt tac tct tcc att gtc act 240 Leu Ser His Leu Ser Phe Val Asp Phe Cys Tyr Ser Ser Ile Val Thr 65 70 75 80 ccc aag ctg ctt gag aac ttg gta atg gca gat aaa agc atc ttc tac 288 Pro Lys Leu Leu Glu Asn Leu Val Met Ala Asp Lys Ser Ile Phe Tyr 85 90 95 ttt agc tgc atg atg cag tac ttc ctg tcc tgc act gct gtg gtg aca 336 Phe Ser Cys Met Met Gln Tyr Phe Leu Ser Cys Thr Ala Val Val Thr 100 105 110 gag tct ttc ttg ctg gca gtg atg gcc tat gac cgc ttt gtg gcc atc 384 Glu Ser Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile 115 120 125 tgc aat cct ctg ctt tat aca gtg gcc atg tca cag agg ctc tgt gcc 432 Cys Asn Pro Leu Leu Tyr Thr Val Ala Met Ser Gln Arg Leu Cys Ala 130 135 140 ctg ctg gtg gct ggg tca tat ctc tgg ggc atg ttt ggc ccc ttg gta 480 Leu Leu Val Ala Gly Ser Tyr Leu Trp Gly Met Phe Gly Pro Leu Val 145 150 155 160 ctc ctt tgt tat gct ctc cgg tta aac ttc tct gga cct aat gta atc 528 Leu Leu Cys Tyr Ala Leu Arg Leu Asn Phe Ser Gly Pro Asn Val Ile 165 170 175 aac cac ttc ttt tgt gag tat act gct ctc atc tct gtg tct ggc tct 576 Asn His Phe Phe Cys Glu Tyr Thr Ala Leu Ile Ser Val Ser Gly Ser 180 185 190 gat ata ctc atc ccc cac ctg ctg ctt ttc agc ttc gcc acc ttc aat 624 Asp Ile Leu Ile Pro His Leu Leu Leu Phe Ser Phe Ala Thr Phe Asn 195 200 205 gag atg tgt aca cta ctg atc atc ctc act tcc tat gtt ttc att ttt 672 Glu Met Cys Thr Leu Leu Ile Ile Leu Thr Ser Tyr Val Phe Ile Phe 210 215 220 gtg act gta cta aaa atc cgt tct gtt agt ggg cgc cac aaa gcc ttc 720 Val Thr Val Leu Lys Ile Arg Ser Val Ser Gly Arg His Lys Ala Phe 225 230 235 240 tcc acc tgg gcc tcc cac ctg act tct atc acc atc ttc cat ggg acc 768 Ser Thr Trp Ala Ser His Leu Thr Ser Ile Thr Ile Phe His Gly Thr 245 250 255 atc ctt ttc ctt tac tgt gta ccc aac tcc aaa aac tct cgg caa aca 816 Ile Leu Phe Leu Tyr Cys Val Pro Asn Ser Lys Asn Ser Arg Gln Thr 260 265 270 gtc aaa gtg gcc tct gta ttt tac aca gtt gtc aac ccc atg ctg aac 864 Val Lys Val Ala Ser Val Phe Tyr Thr Val Val Asn Pro Met Leu Asn 275 280 285 cct ctg atc tac agc cta agg aat aaa gac gtg aag gat gct ttc tgg 912 Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Asp Ala Phe Trp 290 295 300 aag tta ata cat aca caa gtt cca ttt cac tga 945 Lys Leu Ile His Thr Gln Val Pro Phe His 305 310 315 <210> 264 <211> 314 <212> PRT <213> Homo sapiens <400> 264 Met Met Met Val Leu Arg Asn Leu Ser Met Glu Pro Thr Phe Ala Leu 1 5 10 15 Leu Gly Phe Thr Asp Tyr Pro Lys Leu Gln Ile Pro Leu Phe Leu Val 20 25 30 Phe Leu Leu Met Tyr Val Ile Thr Val Val Gly Asn Leu Gly Met Ile 35 40 45 Ile Ile Ile Lys Ile Asn Pro Lys Phe His Thr Pro Met Tyr Phe Phe 50 55 60 Leu Ser His Leu Ser Phe Val Asp Phe Cys Tyr Ser Ser Ile Val Thr 65 70 75 80 Pro Lys Leu Leu Glu Asn Leu Val Met Ala Asp Lys Ser Ile Phe Tyr 85 90 95 P he Ser Cys Met Met Gln Tyr Phe Leu Ser Cys Thr Ala Val Val Thr 100 105 110 Glu Ser Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile 115 120 125 Cys Asn Pro Leu Leu Tyr Thr Val Ala Met Ser Gln Arg Leu Cys Ala 130 135 140 Leu Leu Val Ala Gly Ser Tyr Leu Trp Gly Met Phe Gly Pro Leu Val 145 150 155 160 Leu Leu Cys Tyr Ala Leu Arg Leu Asn Phe Ser Gly Pro Asn Val Ile 165 170 175 Asn His Phe Phe Cys Glu Tyr Thr Ala Leu Ile Ser Val Ser Gly Ser 180 185 190 Asp Ile Leu Ile Pro His Leu Leu Leu Phe Ser Phe Ala Thr Phe Asn 195 200 205 Glu Met Cys Thr Leu Leu Ile Ile Leu Thr Ser Tyr Val Phe Ile Phe 210 215 220 Val Thr Val Leu Lys Ile Arg Ser Val Ser Gly Arg His Lys Ala Phe 225 230 235 240 Ser Thr Trp Ala Ser His Leu Thr Ser Ile Thr Ile Phe His Gly Thr 245 250 255 Ile Leu Phe Leu Tyr Cys Val Pro Asn Ser Lys Asn Ser Arg Gln Thr 260 265 270 Val Lys Val Ala Ser Val Phe Tyr Thr Val Val Asn Pro Met Leu Asn 275 280 285 Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Asp Ala Phe Trp 290 295 300 Lys Leu Ile His Thr Gln Val Pro Phe His 305 310 <210> 265 <211> 942 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(942) <400> 265 atg ctg ctg act gat aga aat aca agt ggg acc acg ttc acc ctc ttg 48 Met Leu Leu Thr Asp Arg Asn Thr Ser Gly Thr Thr Phe Thr Leu Leu 1 5 10 15 ggc ttc tca gat tac cca gaa ctg caa gtc cca ctc ttc ctg gtt ttt 96 Gly Phe Ser Asp Tyr Pro Glu Leu Gln Val Pro Leu Phe Leu Val Phe 20 25 30 ctg gcc atc tac aat gtc act gtg cta ggg aat att ggg ttg att gtg 144 Leu Ala Ile Tyr Asn Val Thr Val Leu Gly Asn Ile Gly Leu Ile Val 35 40 45 atc atc aaa atc aac ccc aaa ctg cat acc ccc atg tac ttt ttc ctc 192 Ile Ile Lys Ile Asn Pro Lys Leu His Thr Pro Met Tyr Phe Phe Leu 50 55 60 agc caa ctc tcc ttt gtg gat ttc tgc tat tcc tcc atc att gct ccc 240 Ser Gln Leu Ser Phe Val Asp Phe Cys Tyr Ser Ser Ile Ile Ala Pro 65 70 75 80 aag atg ttg gtg aac ctt gtt gtc aaa gac aga acc att tca ttt tta 288 Lys Met Leu Val Asn Leu Val Val Lys Asp Arg Thr Ile Ser Phe Leu 85 90 95 gga tgc gta gta caa ttc ttt ttc ttc tgt acc ttt gtg gtc act gaa 336 Gly Cys Val Val Gln Phe Phe Phe Phe Cys Thr Phe Val Val Thr Glu 100 105 110 tcc ttt tta tta gct gtg atg gcc tat gac cgc ttc gtg gcc att tgc 384 Ser Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys 115 120 125 aac cct ctg ctc tac aca gtt aac atg tcc cag aaa ctc tgc gtg ctg 432 Asn Pro Leu Leu Tyr Thr Val Asn Met Ser Gln Lys Leu Cys Val Leu 130 135 140 ctg gtt gtg gga tcc tat gcc tgg gga gtc tca tgt tcc ttg gaa ctg 480 Leu Val Val Gly Ser Tyr Ala Trp Gly Val Ser Cys Ser Leu Glu Leu 145 150 155 160 acg tgc tct gct tta aag tta tgt ttt cat ggt ttc aac aca atc aat 528 Thr Cys Ser Ala Leu Lys Leu Cys Phe His Gly Phe Asn Thr Ile Asn 165 170 175 cac ttc ttc tgt gag ttc tcc tca cta ctc tcc ctt tct tgc tct gat 576 His Phe Phe Cys Glu Phe Ser Ser Leu Leu Ser Leu Ser Cys Ser Asp 180 185 190 act tac atc aac cag tgg ctg cta ttc ttt ctt gcc acc ttt aat gaa 624 Thr Tyr Ile Asn Gln Trp Leu Leu Phe Phe Leu Ala Thr Phe Asn Glu 195 200 205 atc agc aca cta ctc atc gtt ctc aca tct tat gcg ttc att gtt gta 672 Ile Ser Thr Leu Leu Ile Val Leu Thr Ser Tyr Ala Phe Ile Val Val 210 215 220 acc atc ctc aag atg cgt tca gtc agt ggg cgc cgc aaa gcc ttc tcc 720 Thr Ile Leu Lys Met Arg Ser Val Ser Gly Arg Arg Lys Ala Phe Ser 225 230 235 240 acc tgt gcc tcc cac ctg act gcc atc acc atc ttc cat ggc acc atc 768 Thr Cys Ala Ser His Leu Thr Ala Ile Thr Ile Phe His Gly Thr Ile 245 250 255 ctc ttc ctt tac tgt gtg ccc aac tcc aaa aac tcc agg cac aca gtc 816 Leu Phe Leu Tyr Cys Val Pro Asn Ser Lys Asn Ser Arg His Thr Val 260 265 270 aaa gtg gcc tct gtg ttt tac acc gtg gtg atc ccc atg ttg aat ccc 864 Lys Val Ala Ser Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro 275 280 285 ctg atc tac agt ctg aga aat aaa gat gtc aag gat aca gtc acc gag 912 Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Asp Thr Val Thr Glu 290 295 300 ata ctg gac acc aaa gtc ttc tct tac tga 942 Ile Leu Asp Thr Lys Val Phe Ser Tyr 305 310 <210> 266 <211> 313 <212> PRT <213> Homo sapiens <400> 266 Met Leu Leu Thr Asp Arg Asn Thr Ser Gly Thr Thr Phe Thr Leu Leu 1 5 10 15 Gly Phe Ser Asp Tyr Pro Glu Leu Gln Val Pro Leu Phe Leu Val Phe 20 25 30 Leu Ala Ile Tyr Asn Val Thr Val Leu Gly Asn Ile Gly Leu Ile Val 35 40 45 Ile Ile Lys Ile Asn Pro Lys Leu His Thr Pro Met Tyr Phe Phe Leu 50 55 60 Ser Gln Leu Ser Phe Val Asp Phe Cys Tyr Ser Ser Ile Ile Ala Pro 65 70 75 80 Lys Met Leu Val Asn Leu Val Val Lys Asp Arg Thr Ile Ser Phe Leu 85 90 95 Gly Cys Val Val Gln Phe Phe Phe Phe Cys Thr Phe Val Val Thr Glu 100 105 110 Ser Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys 115 120 125 Asn Pro Leu Leu Tyr Thr Val Asn Met Ser Gln Lys Leu Cys Val Leu 130 135 140 Leu Val Val Gly Ser Tyr Ala Trp Gly Val Ser Cys Ser Leu Glu Leu 145 150 155 160 Thr Cys Ser Ala Leu Lys Leu Cys Phe His Gly Phe Asn Thr Ile Asn 165 170 175 His Phe Phe Cys Glu Phe Ser Ser Leu Leu Ser Leu Ser Cys Ser Asp 180 185 190 Thr Tyr Ile Asn Gln Trp Leu Leu Phe Phe Leu Ala Thr Phe Asn Glu 195 200 205 Ile Ser Thr Leu Leu Ile Val Leu Thr Ser Tyr Ala Phe Ile Val Val 210 215 220 Thr Ile Leu Lys Met Arg Ser Val Ser Gly Arg Arg Lys Ala Phe Ser 225 230 235 240 Thr Cys Ala Ser His Leu Thr Ala Ile Thr Ile Phe His Gly Thr Ile 245 250 255 Leu Phe Leu Tyr Cys Val Pro Asn Ser Lys Asn Ser Arg His Thr Val 260 265 270 Lys Val Ala Ser Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro 275 280 285 Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Asp Thr Val Thr Glu 290 295 300 Ile Leu Asp Thr Lys Val Phe Ser Tyr 305 310 <210> 267 <211> 771 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(771) <400> 267 atg tac ttt ttc ctc agt cat cta tcc ttt ttg gat act tgt tat tcc 48 Met Tyr Phe Phe Leu Ser His Leu Ser Phe Leu Asp Thr Cys Tyr Ser 1 5 10 15 aat gta ttt aca ccc aaa ctg tta gag att ttg gtt gtg gaa gac aga 96 Asn Val Phe Thr Pro Lys Leu Leu Glu Ile Leu Val Val Glu Asp Arg 20 25 30 act atc tcc ttc aaa gga tgc atg gta caa ttt ttc ttt ggt tgt gca 144 Thr Ile Ser Phe Lys Gly Cys Met Val Gln Phe Phe Phe Gly Cys Ala 35 40 45 ttt gta atc aca gaa atg ttc atg tta gcg gtg atg gct tat gac ttg 192 Phe Val Ile Thr Glu Met Phe Met Leu Ala Val Met Ala Tyr Asp Leu 50 55 60 ttt atg gct gtt tgt aac ccc ctg ctc tac aca gtg gct atg tct cct 240 Phe Met Ala Val Cys Asn Pro Leu Leu Tyr Thr Val Ala Met Ser Pro 65 70 75 80 aag ctc tgt gct ctc ctg gta act gga act tac aca tgg ggt gga ctc 288 Lys Leu Cys Ala Leu Leu Val Thr Gly Thr Tyr Thr Trp Gly Gly Leu 85 90 95 tgt tcc ctg aca ctc act tat tct ctt ttg gtg tta tcc tac tgt gga 336 Cys Ser Leu Thr Leu Thr Tyr Ser Leu Leu Val Leu Ser Tyr Cys Gly 100 105 110 tct aac atc ata aat cac ttt ggc tgt gag tac tct gcc att ctt tct 384 Ser Asn Ile Ile Asn His Phe Gly Cys Glu Tyr Ser Ala Ile Leu Ser 115 120 125 cta tcc tgc tct gat ccc tac ttc aac cag atg gcg tgt tta gtc att 432 Leu Ser Cys Ser Asp Pro Tyr Phe Asn Gln Met Ala Cys Leu Val Ile 130 135 140 tct ata ttc agt gaa gct tgt agc ctc ctg gcc atc ctt gcc ttc tat 480 Ser Ile Phe Ser Glu Ala Cys Ser Leu Leu Ala Ile Leu Ala Phe Tyr 145 150 155 160 gtc ttc ata gtt gcc act gtc atc aag atg ctt tct acg ggt gga ccc 528 Val Phe Ile Val Ala Thr Val Ile Lys Met Leu Ser Thr Gly Gly Pro 165 170 175 caa aag gcc atc tcc acc tgt gcc tcc cac ctg acc acc gtc tcc att 576 Gln Lys Ala Ile Ser Thr Cys Ala Ser His Leu Thr Thr Val Ser Ile 180 185 190 ttc cat ggg gtc atc ctg ctc ctt tac tgt gtg ccc aac tcc aaa agc 624 Phe His Gly Val Ile Leu Leu Leu Tyr Cys Val Pro Asn Ser Lys Ser 195 200 205 tca tgg ctc ctg gtc aaa gtg gct act gta ctt ttt aca gtc ata atc 672 Ser Trp Leu Leu Val Lys Val Ala Thr Val Leu Phe Thr Val Ile Ile 210 215 220 cct atg ctg aat ccc ctg atc tac agc ctt agg aac aaa gat gta aaa 720 Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys 225 230 235 240 ga g acc gtc agg aag ttg ata aac tcc caa tca cct ttt cac tca aaa 768 Glu Thr Val Arg Lys Leu Ile Asn Ser Gln Ser Pro Phe His Ser Lys 245 250 255 taa 771 <210> 268 <211> 256 <212> PRT <213> Homo sapiens <400> 268 Met Tyr Phe Phe Leu Ser His Leu Ser Phe Leu Asp Thr Cys Tyr Ser 1 5 10 15 Asn Val Phe Thr Pro Lys Leu Leu Glu Ile Leu Val Val Glu Asp Arg 20 25 30 Thr Ile Ser Phe Lys Gly Cys Met Val Gln Phe Phe Phe Gly Cys Ala 35 40 45 Phe Val Ile Thr Glu Met Phe Met Leu Ala Val Met Ala Tyr Asp Leu 50 55 60 Phe Met Ala Val Cys Asn Pro Leu Leu Tyr Thr Val Ala Met Ser Pro 65 70 75 80 Lys Leu Cys Ala Leu Leu Val Thr Gly Thr Tyr Thr Trp Gly Gly Leu 85 90 95 Cys Ser Leu Thr Leu Thr Tyr Ser Leu Leu Val Leu Ser Tyr Cys Gly 100 105 110 Ser Asn Ile Ile Asn His Phe Gly Cys Glu Tyr Ser Ala Ile Leu Ser 115 120 125 Leu Ser Cys Ser Asp Pro Tyr Phe Asn Gln Met Ala Cys Leu Val Ile 130 135 140 S er Ile Phe Ser Glu Ala Cys Ser Leu Leu Ala Ile Leu Ala Phe Tyr 145 150 155 160 Val Phe Ile Val Ala Thr Val Ile Lys Met Leu Ser Thr Gly Gly Pro 165 170 175 Gln Lys Ala Ile Ser Thr Cys Ala Ser His Leu Thr Thr Val Ser Ile 180 185 190 Phe His Gly Val Ile Leu Leu Leu Tyr Cys Val Pro Asn Ser Lys Ser 195 200 205 Ser Trp Leu Leu Val Lys Val Ala Thr Val Leu Phe Thr Val Ile Ile 210 215 220 Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys 225 230 235 240 Glu Thr Val Arg Lys Leu Ile Asn Ser Gln Ser Pro Phe His Ser Lys 245 250 255 <210> 269 <211> 987 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(987) <400> 269 atg aag ctg tgg atg gag agt cac ctg ata gtc cca gaa acc cgt ccc 48 Met Lys Leu Trp Met Glu Ser His Leu Ile Val Pro Glu Thr Arg Pro 1 5 10 15 agc cca agg atg atg agt aac cag acg ttg gta acc gag ttc atc ctg 96 Ser Pro Arg Met Met Ser Asn Gln Thr Leu Val Thr Glu Phe Ile Leu 20 25 30 cag ggc ttt tcg gag cac cca gaa tac cgg gtg ttc tta ttc agc tgt 144 Gln Gly Phe Ser Glu His Pro Glu Tyr Arg Val Phe Leu Phe Ser Cys 35 40 45 ttc ctc ttc ctc tac tct ggg gcc ctc aca ggt aat gtc ctc atc acc 192 Phe Leu Phe Leu Tyr Ser Gly Ala Leu Thr Gly Asn Val Leu Ile Thr 50 55 60 ttg gcc atc acg ttc aac cct ggg ctc cac gct cct atg tac ttt ttc 240 Leu Ala Ile Thr Phe Asn Pro Gly Leu His Ala Pro Met Tyr Phe Phe 65 70 75 80 tta ctc aac ttg gct act atg gac att atc tgc acc tct tcc atc atg 288 Leu Leu Asn Leu Ala Thr Met Asp Ile Ile Cys Thr Ser Ser Ile Met 85 90 95 ccc aag gcg ctg gcc agt ctg gtg tcg gaa gag agc tcc atc tcc tac 336 Pro Lys Ala Leu Ala Ser Leu Val Ser Glu Glu Ser Ser Ile Ser Tyr 100 105 110 ggg ggc tgc atg gcc cag ctc tat ttc ctc acg tgg gct gca tcc tca 384 Gly Gly Cys Met Ala Gln Leu Tyr Phe Leu Thr Trp Ala Ala Ser Ser 115 120 125 gag ctg ctg ctc ctc acg gtc atg gcc tat gac cgg tac gca gcc atc 432 Glu Leu Leu Leu Leu Thr Val Met Ala Tyr Asp Arg Tyr Ala Ala Ile 130 135 140 tgc cac ccg ctg cat tac agc agc atg atg agc aag gtg ttc tgc agc 480 Cys His Pro Leu His Tyr Ser Ser Met Met Ser Lys Val Phe Cys Ser 145 150 155 160 ggg ctg gcc aca gcc gtg tgg ctg ctc tgc gcc gtc aac acg gcc atc 528 Gly Leu Ala Thr Ala Val Trp Leu Leu Cys Ala Val Asn Thr Ala Ile 165 170 175 cac acg ggg ctg atg ctg cgc ttg gat ttc tgt ggc ccc aat gtc att 576 His Thr Gly Leu Met Leu Arg Leu Asp Phe Cys Gly Pro Asn Val Ile 180 185 190 atc cat ttc ttc tgc gag gtc cct ccc ctg ctg ctt ctc tcc tgc agc 624 Ile His Phe Phe Cys Glu Val Pro Pro Leu Leu Leu Leu Ser Cys Ser 195 200 205 tcc acc tac gtc aac ggt gtc atg att gtc ctg gcg gat gct ttc tac 672 Ser Thr Tyr Val Asn Gly Val Met Ile Val Leu Ala Asp Ala Phe Tyr 210 215 220 ggc ata gtg aac ttc ctg atg acc atc gcg tcc tat ggc ttc atc gtc 720 Gly Ile Val Asn Phe Leu Met Thr Ile Ala Ser Tyr Gly Phe Ile Val 225 230 235 240 tcc agc atc ctg aag gtg aag act gcc tgg ggg agg cag aaa gcc ttc 768 Ser Ser Ile Leu Lys Val Lys Thr Ala Trp Gly Arg Gln Lys Ala Phe 245 250 255 tcc acc tgc tct tcc cac ctc acc gtg gtg tgc atg tat tac acc gct 816 Ser Thr Cys Ser Ser His Leu Thr Val Val Cys Met Tyr Tyr Thr Ala 260 265 270 gtc ttc tac gcc tac ata agc ccg gtc tct ggc tac agc gca ggg aag 864 Val Phe Tyr Ala Tyr Ile Ser Pro Val Ser Gly Tyr Ser Ala Gly Lys 275 280 285 agc aag ttg gct ggc ctg ctg tac act gtg ctg agt cct acc ctc aac 912 Ser Lys Leu Ala Gly Leu Leu Tyr Thr Val Leu Ser Pro Thr Leu Asn 290 295 300 ccc ctc atc tat act ttg aga aac aag gag gtc aaa gca gcc ctc agg 960 Pro Leu Ile Tyr Thr Leu Arg Asn Lys Glu Val Lys Ala Ala Leu Arg 305 310 315 320 aag ctt ttc cct ttc ttc aga aat taa 987 Lys Leu Phe Pro Phe Phe Arg Asn 325 <210> 270 <211> 328 <212> PRT <213> Homo sapiens <400> 270 Met Lys Leu Trp Met Glu Ser His Leu Ile Val Pro Glu Thr Arg Pro 1 5 10 15 Ser Pro Arg Met Met Ser Asn Gln Thr Leu Val Thr Glu Phe Ile Leu 20 25 30 Gln Gly Phe Ser Glu His Pro Glu Tyr Arg Val Phe Leu Phe Ser Cys 35 40 45 Phe Leu Phe Leu Tyr Ser Gly Ala Leu Thr Gly Asn Val Leu Ile Thr 50 55 60 Leu Ala Ile Thr Phe Asn Pro Gly Leu His Ala Pro Met Tyr Phe Phe 65 70 75 80 Leu Leu Asn Leu Ala Thr Met Asp Ile Ile Cys Thr Ser Ser Ile Met 85 90 95 Pro Lys Ala Leu Ala Ser Leu Val Ser Glu Glu Ser Ser Ile Ser Tyr 100 105 110 Gly Gly Cys Met Ala Gln Leu Tyr Phe Leu Thr Trp Ala Ala Ser Ser 115 120 125 Glu Leu Leu Leu Leu Thr Val Met Ala Tyr Asp Arg Tyr Ala Ala Ile 130 135 140 Cys His Pro Leu His Tyr Ser Ser Met Met Ser Lys Val Phe Cys Ser 145 150 155 160 Gly Leu Ala Thr Ala Val Trp Leu Leu Cys Ala Val Asn Thr Ala Ile 165 170 175 His Thr Gly Leu Met Leu Arg Leu Asp Phe Cys Gly Pro Asn Val Ile 180 185 190 Ile His Phe Phe Cys Glu Val Pro Pro Leu Leu Leu Leu Ser Cys Ser 195 200 205 Ser Thr Tyr Val Asn Gly Val Met Ile Val Leu Ala Asp Ala Phe Tyr 210 215 220 Gly Ile Val Asn Phe Leu Met Thr Ile Ala Ser Tyr Gly Phe Ile Val 225 230 235 240 Ser Ser Ile Leu Lys Val Lys Thr Ala Trp Gly Arg Gln Lys Ala Phe 245 250 255 Ser Thr Cys Ser Ser His Leu Thr Val Val Cys Met Tyr Tyr Thr Ala 260 265 270 Val Phe Tyr Ala Tyr Ile Ser Pro Val Ser Gly Tyr Ser Ala Gly Lys 275 280 285 Ser Lys Leu Ala Gly Leu Leu Tyr Thr Val Leu Ser Pro Thr Leu Asn 290 295 300 Pro Leu Ile Tyr Thr Leu Arg Asn Lys Glu Val Lys Ala Ala Leu Arg 305 310 315 320 Lys Leu Phe Pro Phe Phe Arg Asn 325 <210> 271 <211> 915 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(915) <400> 271 atg ttg atg aat tac tct agt gcc act gaa ttt tat ctc ctt ggc ttc 48 Met Leu Met Asn Tyr Ser Ser Ala Thr Glu Phe Tyr Leu Leu Gly Phe 1 5 10 15 cct ggc tct gaa gaa cta cat cat atc ctt ttt gct ata ttc ttc ttt 96 Pro Gly Ser Glu Glu Leu His His Ile Leu Phe Ala Ile Phe Phe Phe 20 25 30 ttc tac ttg gtg aca tta atg gga aac aca gtc atc atc atg att gtc 144 Phe Tyr Leu Val Thr Leu Met Gly Asn Thr Val Ile Ile Met Ile Val 35 40 45 tgt gtg gat aaa cgt ctg cag tcc ccc atg tat ttc ttc ctc ggc cac 192 Cys Val Asp Lys Arg Leu Gln Ser Pro Met Tyr Phe Phe Leu Gly His 50 55 60 ctc tct gcc ctg gag atc ctg gtc aca acc ata atc gtc ccc gtg atg 240 Leu Ser Ala Leu Glu Ile Leu Val Thr Thr Ile Ile Val Pro Val Met 65 70 75 80 ctt tgg gga ttg ctg ctc cct ggg atg cag aca ata tat ttg tct gcc 288 Leu Trp Gly Leu Leu Leu Pro Gly Met Gln Thr Ile Tyr Leu Ser Ala 85 90 95 tgt gtt gtc cag ctc ttc ttg tac ctt gct gtg ggg aca aca gag ttc 336 Cys Val Val Gln Leu Phe Leu Tyr Leu Ala Val Gly Thr Thr Glu Phe 100 105 110 gca tta ctt gga gca atg gct gtg gac cgt tat gtg gct gtc tgt aac 384 Ala Leu Leu Gly Ala Met Ala Val Asp Arg Tyr Val Ala Val Cys Asn 115 120 125 cct ctg agg tac aac atc att atg aac aga cac acc tgc aac ttt gtg 432 Pro Leu Arg Tyr Asn Ile Ile Met Asn Arg His Thr Cys Asn Phe Val 130 135 140 gtt ctt gtg tca tgg gtg ttt ggg ttt ctt ttt caa atc tgg ccg gtc 480 Val Leu Val Ser Trp Val Phe Gly Phe Leu Phe Gln Ile Trp Pro Val 145 150 155 160 tat gtc atg ttt cag ctt act tac tgc aaa tca aat gtg gtg aac aat 528 T yr Val Met Phe Gln Leu Thr Tyr Cys Lys Ser Asn Val Val Asn Asn 165 170 175 ttt ttt tgt gac cga ggg caa ttg ctc aaa cta tcc tgc aat aat act 576 Phe Phe Cys Asp Arg Gly Gln Leu Leu Lys Leu Ser Cys Asn Asn Thr 180 185 190 ctt ttc acg gag ttt atc ctc ttc tta atg gct gtt ttt gtt ctc ttt 624 Leu Phe Thr Glu Phe Ile Leu Phe Leu Met Ala Val Phe Val Leu Phe 195 200 205 ggt tct ttg atc cct aca att gtc tcc aac gcc tac atc atc tcc acc 672 Gly Ser Leu Ile Pro Thr Ile Val Ser Asn Ala Tyr Ile Ile Ser Thr 210 215 220 att ctc aag atc ccg tca tcc tct ggc cgg agg aaa tcc ttc tcc act 720 Ile Leu Lys Ile Pro Ser Ser Ser Gly Arg Arg Lys Ser Phe Ser Thr 225 230 235 240 tgt gcc tcc cac ttc acc tgt gtt gtg att ggc tac ggc agc tgc ttg 768 Cys Ala Ser His Phe Thr Cys Val Val Ile Gly Tyr Gly Ser Cys Leu 245 250 255 ttt ctc tac gtg aaa ccc aag caa acg cag gca gct gat tac aat tgg 816 Phe Leu Tyr Val Lys Pro Lys Gln Thr Gln Ala Ala Asp Tyr Asn Trp 260 265 270 gta gtt tcc ctg atg gtt tca gta gta act cct ttc ctc aat cct ttc 864 Val Val Ser Leu Met Val Ser Val Val Thr Pro Phe Leu Asn Pro Phe 275 280 285 atc ttc acc ctc cgg aat gat aaa gtc ata gag gcc ctt cgg atg ggg 912 Ile Phe Thr Leu Arg Asn Asp Lys Val Ile Glu Ala Leu Arg Met Gly 290 295 300 tga 915 305 <210> 272 <211> 304 <212> PRT <213> Homo sapiens <400> 272 Met Leu Met Asn Tyr Ser Ser Ala Thr Glu Phe Tyr Leu Leu Gly Phe 1 5 10 15 Pro Gly Ser Glu Glu Leu His His Ile Leu Phe Ala Ile Phe Phe Phe 20 25 30 Phe Tyr Leu Val Thr Leu Met Gly Asn Thr Val Ile Ile Met Ile Val 35 40 45 Cys Val Asp Lys Arg Leu Gln Ser Pro Met Tyr Phe Phe Leu Gly His 50 55 60 Leu Ser Ala Leu Glu Ile Leu Val Thr Thr Ile Ile Val Pro Val Met 65 70 75 80 Leu Trp Gly Leu Leu Leu Pro Gly Met Gln Thr Ile Tyr Leu Ser Ala 85 90 95 Cys Val Val Gln Leu Phe Leu Tyr Leu Ala Val Gly Thr Thr Glu Phe 100 105 110 Ala Leu Leu Gly Ala Met Ala Val Asp Arg Tyr Val Ala Val Cys Asn 115 120 125 Pro Leu Arg Tyr Asn Ile Ile Met Asn Arg His Thr Cys Asn Phe Val 130 135 140 Val Leu Val Ser Trp Val Phe Gly Phe Leu Phe Gln Ile Trp Pro Val 145 150 155 160 Tyr Val Met Phe Gln Leu Thr Tyr Cys Lys Ser Asn Val Val Asn Asn 165 170 175 Phe Phe Cys Asp Arg Gly Gln Leu Leu Lys Leu Ser Cys Asn Asn Thr 180 185 190 Leu Phe Thr Glu Phe Ile Leu Phe Leu Met Ala Val Phe Val Leu Phe 195 200 205 Gly Ser Leu Ile Pro Thr Ile Val Ser Asn Ala Tyr Ile Ile Ser Thr 210 215 220 Ile Leu Lys Ile Pro Ser Ser Ser Gly Arg Arg Lys Ser Phe Ser Thr 225 230 235 240 Cys Ala Ser His Phe Thr Cys Val Val Ile Gly Tyr Gly Ser Cys Leu 245 250 255 Phe Leu Tyr Val Lys Pro Lys Gln Thr Gln Ala Ala Asp Tyr Asn Trp 260 265 270 Val Val Ser Leu Met Val Ser Val Val Thr Pro Phe Leu Asn Pro Phe 275 280 285 Ile Phe Thr Leu Arg Asn Asp Lys Val Ile Glu Ala Leu Arg Met Gly 290 295 300 <210> 273 <211> 792 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(792) <400> 273 atg ttg ggg aat tac tct agc gcc act gaa ttt ttt ctc tta ggc ttc 48 Met Leu Gly Asn Tyr Ser Ser Ala Thr Glu Phe Phe Leu Leu Gly Phe 1 5 10 15 cct ggc tcc caa gaa gta tgc cgt atc cta ttt gcg acc ttc ttc ctc 96 Pro Gly Ser Gln Glu Val Cys Arg Ile Leu Phe Ala Thr Phe Phe Leu 20 25 30 ttg tat gca gtg aca gtg atg gga aac gtg gtc atc atc atc act gtc 144 Leu Tyr Ala Val Thr Val Met Gly Asn Val Val Ile Ile Ile Thr Val 35 40 45 tgt gtt gat aaa tgt ctg cag tcc ccc att tat ttt ttc ctg ggc cac 192 Cys Val Asp Lys Cys Leu Gln Ser Pro Ile Tyr Phe Phe Leu Gly His 50 55 60 ctc tgt gtc ctg gag atc ctg atc aca tcc acc gct gtc cct ttt atg 240 Leu Cys Val Leu Glu Ile Leu Ile Thr Ser Thr Ala Val Pro Phe Met 65 70 75 80 ctc tgg ggg ttg ctg ctt cca agc acc cag atc atg tct ttg aca gcc 288 Leu Trp Gly Leu Leu Leu Pro Ser Thr Gln Ile Met Ser Leu Thr Ala 85 90 95 tgt gct gca cag cta tat tta tac ctt tct ttg ggt acc ttg gag ttg 336 Cys Ala Ala Gln Leu Tyr Leu Tyr Leu Ser Leu Gly Thr Leu Glu Leu 100 105 110 gca tta atg gga gtg atg gct gtg gac cgt tat gtg gct gtg tgt aac 384 Ala Leu Met Gly Val Met Ala Val Asp Arg Tyr Val Ala Val Cys Asn 115 120 125 cct ttg agg tac aac atc att atg aac agc agc acc ttc att tgg gtg 432 Pro Leu Arg Tyr Asn Ile Ile Met Asn Ser Ser Thr Phe Ile Trp Val 130 135 140 ata att gtg tca tgg gtt ttg ggg ttt ctt tct gaa atc tgg cca gtt 480 Ile Ile Val Ser Trp Val Leu Gly Phe Leu Ser Glu Ile Trp Pro Val 145 150 155 160 tat gcc act ttt cag ctt act ttc tgc aaa tca agt gtg tta gat cat 528 Tyr Ala Thr Phe Gln Leu Thr Phe Cys Lys Ser Ser Val Leu Asp His 165 170 175 ttt tat tgt gac cga gga caa ttg ctc aag gta tcc tgt gag gac act 576 Phe Tyr Cys Asp Arg Gly Gln Leu Leu Lys Val Ser Cys Glu Asp Thr 180 185 190 ctt ttc aga gag ttt att ctt ttt cta atg gct gtt ttc att atc att 624 Leu Phe Arg Glu Phe Ile Leu Phe Leu Met Ala Val Phe Ile Ile Ile 195 200 205 ggt tct ttg atc cct acg att gtc tcc tac acc tac atc atc tcc acc 672 Gly Ser Leu Ile Pro Thr Ile Val Ser Tyr Thr Tyr Ile Ile Ser Thr 210 215 220 aac ctc aag att ccg tca gcc tct ggc tgg agg aaa tcc ttt tcc acc 720 Asn Leu Lys Ile Pro Ser Ala Ser Gly Trp Arg Lys Ser Phe Ser Thr 225 230 235 240 tgt gcc tcc cac ttc acc tat gtt gtg att ggc tat ggc agc tgc ttg 768 Cys Ala Ser His Phe Thr Tyr Val Val Ile Gly Tyr Gly Ser Cys Leu 245 250 255 ttt ctc tac gtg aaa ccc aag taa 792 Phe Leu Tyr Val Lys Pro Lys 260 <210> 274 <211> 263 <212> PRT <213> Homo sapiens <400> 274 Met Leu Gly Asn Tyr Ser Ser Ala Thr Glu Phe Phe Leu Leu Gly Phe 1 5 10 15 Pro Gly Ser Gln Glu Val Cys Arg Ile Leu Phe Ala Thr Phe Phe Leu 20 25 30 Leu Tyr Ala Val Thr Val Met Gly Asn Val Val Ile Ile Ile Thr Val 35 40 45 Cys Val Asp Lys Cys Leu Gln Ser Pro Ile Tyr Phe Phe Leu Gly His 50 55 60 Leu Cys Val Leu Glu Ile Leu Ile Thr Ser Thr Ala Val Pro Phe Met 65 70 75 80 Leu Trp Gly Leu Leu Leu Pro Ser Thr Gln Ile Met Ser Leu Thr Ala 85 90 95 Cys Ala Ala Gln Leu Tyr Leu Tyr Leu Ser Leu Gly Thr Leu Glu Leu 100 105 110 Ala Leu Met Gly Val Met Ala Val Asp Arg Tyr Val Ala Val Cys Asn 115 120 125 Pro Leu Arg Tyr Asn Ile Ile Met Asn Ser Ser Thr Phe Ile Trp Val 130 135 140 Ile Ile Val Ser Trp Val Leu Gly Phe Leu Ser Glu Ile Trp Pro Val 145 150 155 160 Tyr Ala Thr Phe Gln Leu Thr Phe Cys Lys Ser Ser Val Leu Asp His 165 170 175 Phe Tyr Cys Asp Arg Gly Gln Leu Leu Lys Val Ser Cys Glu Asp Thr 180 185 190 Leu Phe Arg Glu Phe Ile Leu Phe Leu Met Ala Val Phe Ile Ile Ile 195 200 205 Gly Ser Leu Ile Pro Thr Ile Val Ser Tyr Thr Tyr Ile Ile Ser Thr 210 215 220 Asn Leu Lys Ile Pro Ser Ala Ser Gly Trp Arg Lys Ser Phe Ser Thr 225 230 235 240 Cys Ala Ser His Phe Thr Tyr Val Val Ile Gly Tyr Gly Ser Cys Leu 245 250 255 Phe Leu Tyr Val Lys Pro Lys 260 <210> 275 <211> 1023 <212> DNA <213> Homo sapiens <2 20> <221> CDS <222> (1)..(1023) <400> 275 atg gac tcc act ttc aca ggc tat aac ctt tat aac ctg caa gta aaa 48 Met Asp Ser Thr Phe Thr Gly Tyr Asn Leu Tyr Asn Leu Gln Val Lys 1 5 10 15 act gaa atg gac aag ttg tca tca ggt ttg gat ata tac agg aat cca 96 Thr Glu Met Asp Lys Leu Ser Ser Gly Leu Asp Ile Tyr Arg Asn Pro 20 25 30 ctg aag aac aag act gaa gtc acc atg ttt ata ttg aca ggc ttc aca 144 Leu Lys Asn Lys Thr Glu Val Thr Met Phe Ile Leu Thr Gly Phe Thr 35 40 45 gat gat ttt gag ctg caa gtc ttc cta ttt tta cta ttt ttt gca atc 192 Asp Asp Phe Glu Leu Gln Val Phe Leu Phe Leu Leu Phe Phe Ala Ile 50 55 60 tat ctc ttt acc ttg ata ggc aat tta ggg ctg gtt gtg ttg gtc att 240 Tyr Leu Phe Thr Leu Ile Gly Asn Leu Gly Leu Val Val Leu Val Ile 65 70 75 80 gag gat tcc tgg ctc cac aac ccc atg tat tat ttt ctt agt gtt tta 288 Glu Asp Ser Trp Leu His Asn Pro Met Tyr Tyr Phe Leu Ser Val Leu 85 90 95 tca ttc ttg gat gct tgc tat tct aca gtt gtc act cca aaa atg ttg 336 Ser Phe Leu Asp Ala Cys Tyr Ser Thr Val Val Thr Pro Lys Met Leu 100 105 110 gtc aat ttc ctg gca aaa aat aaa tcc att tca ttt atc gga tgt gca 384 Val Asn Phe Leu Ala Lys Asn Lys Ser Ile Ser Phe Ile Gly Cys Ala 115 120 125 aca cag atg ctt ctt ttt gtt act ttt gga act aca gaa tgt ttt ctc 432 Thr Gln Met Leu Leu Phe Val Thr Phe Gly Thr Thr Glu Cys Phe Leu 130 135 140 ttg gct gca atg gct tat gat cac tat gta gcc atc tac aac cct ctc 480 Leu Ala Ala Met Ala Tyr Asp His Tyr Val Ala Ile Tyr Asn Pro Leu 145 150 155 160 ctg tat tca gtg agc atg tca ccc aga gtc tat gtg cca ctc atc act 528 Leu Tyr Ser Val Ser Met Ser Pro Arg Val Tyr Val Pro Leu Ile Thr 165 170 175 gct tcc tac gtt gct ggc att tta cat gct act ata cat ata gtg gct 576 Ala Ser Tyr Val Ala Gly Ile Leu His Ala Thr Ile His Ile Val Ala 180 185 190 aca ttt agc ctg tcc ttc tgt gga tcc aat gaa att agg cat gtc ttt 624 Thr Phe Ser Leu Ser Phe Cys Gly Ser Asn Glu Ile Arg His Val Phe 195 200 205 tgt gat atg cct cct ctc ctt gct att tct tgt tct gac act cac aca 672 Cys Asp Met Pro Pro Leu Leu Ala Ile Ser Cys Ser Asp Thr His Thr 210 215 220 aac cag ctt cta ctc ttc tac ttt gtg ggt tct att gag ata gtc act 720 Asn Gln Leu Leu Leu Phe Tyr Phe Val Gly Ser Ile Glu Ile Val Thr 225 230 235 240 atc ctg att gtc ctc att tcc tgt gat ttc att ctg ttg tcc att ctg 768 Ile Leu Ile Val Leu Ile Ser Cys Asp Phe Ile Leu Leu Ser Ile Leu 245 250 255 aag atg cat tct gct aag gga agg caa aag gcc ttc tct aca tgt ggc 816 Lys Met His Ser Ala Lys Gly Arg Gln Lys Ala Phe Ser Thr Cys Gly 260 265 270 tct cac cta act gga gtg aca att tat cat gga aca att ctc gtc agt 864 Ser His Leu Thr Gly Val Thr Ile Tyr His Gly Thr Ile Leu Val Ser 275 280 285 tat atg aga cca agt tcc agc tat gct tca gac cat gac atc ata gtg 912 Tyr Met Arg Pro Ser Ser Ser Tyr Ala Ser Asp His Asp Ile Ile Val 290 295 300 tca ata ttt tac aca att gtg att ccc aag ttg aat ccc atc atc tat 960 Ser Ile Phe Tyr Thr Ile Val Ile Pro Lys Leu Asn Pro Ile Ile Tyr 305 310 315 320 agt ttg agg aac aaa gaa gta aaa aag gca gtg aag aaa atg ttg aaa 1008 Ser Leu Arg Asn Lys Glu Val Lys Lys Ala Val Lys Lys Met Leu Lys 325 330 335 ttg gtt tac aaa tga 1023 Leu Val Tyr Lys 340 <210> 276 <211> 340 <212> PRT <213> Homo sapiens <400> 276 Met Asp Ser Thr Phe Thr Gly Tyr Asn Leu Tyr Asn Leu Gln Val Lys 1 5 10 15 Thr Glu Met Asp Lys Leu Ser Ser Gly Leu Asp Ile Tyr Arg Asn Pro 20 25 30 Leu Lys Asn Lys Thr Glu Val Thr Met Phe Ile Leu Thr Gly Phe Thr 35 40 45 Asp Asp Phe Glu Leu Gln Val Phe Leu Phe Leu Leu Phe Phe Ala Ile 50 55 60 Tyr Leu Phe Thr Leu Ile Gly Asn Leu Gly Leu Val Val Leu Val Ile 65 70 75 80 Glu Asp Ser Trp Leu His Asn Pro Met Tyr Tyr Phe Leu Ser Val Leu 85 90 95 Ser Phe Leu Asp Ala Cys Tyr Ser Thr Val Val Thr Pro Lys Met Leu 100 105 110 Val Asn Phe Leu Ala Lys Asn Lys Ser Ile Ser Phe Ile Gly Cys Ala 115 120 125 Thr Gln Met Leu Leu Phe Val Thr Phe Gly Thr Thr Glu Cys Phe Leu 130 135 140 Leu Ala Ala Met Ala Tyr Asp His Tyr Val Ala Ile Tyr Asn Pro Leu 145 150 155 160 Leu Tyr Ser Val Ser Met Ser Pro Arg Val Tyr Val Pro Leu Ile Thr 165 170 175 Ala Ser Tyr Val Ala Gly Ile Leu His Ala Thr Ile His Ile Val Ala 180 185 190 Thr Phe Ser Leu Ser Phe Cys Gly Ser Asn Glu Ile Arg His Val Phe 195 200 205 Cys Asp Met Pro Pro Leu Leu Ala Ile Ser Cys Ser Asp Thr His Thr 210 215 220 Asn Gln Leu Leu Leu Phe Tyr Phe Val Gly Ser Ile Glu Ile Val Thr 225 230 235 240 Ile Leu Ile Val Leu Ile Ser Cys Asp Phe Ile Leu Leu Ser Ile Leu 245 250 255 Lys Met His Ser Ala Lys Gly Arg Gln Lys Ala Phe Ser Thr Cys Gly 260 265 270 Ser His Leu Thr Gly Val Thr Ile Tyr His Gly Thr Ile Leu Val Ser 275 280 285 Tyr Met Arg Pro Ser Ser Ser Tyr Ala Ser Asp His Asp Ile Ile Val 290 295 300 Ser Ile Phe Tyr Thr Ile Val Ile Pro Lys Leu Asn Pro Ile Ile Tyr 305 310 315 320 Ser Leu Arg Asn Lys Glu Val Lys Lys Ala Val Lys Lys Met Leu Lys 325 330 335 Leu Val Tyr Lys 340 <210> 277 <211> 939 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(939) <400> 277 atg gaa caa cac aat cta aca acg gtg aat gaa ttc att ctt acg gga 48 Met Glu Gln His Asn Leu Thr Thr Val Asn Glu Phe Ile Leu Thr Gly 1 5 10 15 atc aca gat atc gct gag ctg cag gca cca tta ttt gca ttg ttc ctc 96 Ile Thr Asp Ile Ala Glu Leu Gln Ala Pro Leu Phe Ala Leu Phe Leu 20 25 30 atg atc tat gtg atc tca gtg atg ggc aat ttg ggc atg att gtc ctc 144 Met Ile Tyr Val Ile Ser Val Met Gly Asn Leu Gly Met Ile Val Leu 35 40 45 acc aag ttg gac tcc agg ttg caa acc cct atg tac ttt ttt ctc aga 192 Thr Lys Leu Asp Ser Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg 50 55 60 cat ctg gct ttc atg gat ctt ggt tat tca aca act gtg gga ccc aaa 240 His Leu Ala Phe Met Asp Leu Gly Tyr Ser Thr Thr Val Gly Pro Lys 65 70 75 80 atg tta gta aat ttt gtt gtg gat aag aat ata att tct tat tat ttt 288 Met Leu Val Asn Phe Val Val Asp Lys Asn Ile Ile Ser Tyr Tyr Phe 85 90 95 tgt gca aca cag cta gct ttc ttt ctt gtg ttc att ggt agt gaa ctt 336 Cys Ala Thr Gln Leu Ala Phe Phe Leu Val Phe Ile Gly Ser Glu Leu 100 105 110 ttt att ctc tca gcc atg tcc tac gac ctc tat gtg gcc atc tgt aac 384 Ph e Ile Leu Ser Ala Met Ser Tyr Asp Leu Tyr Val Ala Ile Cys Asn 115 120 125 cct ctg cta tac aca gta atc atg tca cga agg gta tgt cag gtg ctg 432 Pro Leu Leu Tyr Thr Val Ile Met Ser Arg Arg Val Cys Gln Val Leu 130 135 140 gta gca atc cct tac ctc tat tgc aca ttc att tct ctt cta gtc acc 480 Val Ala Ile Pro Tyr Leu Tyr Cys Thr Phe Ile Ser Leu Leu Val Thr 145 150 155 160 ata aag att ttt act tta tcc ttc tgt ggc tac aac gtc att agt cat 528 Ile Lys Ile Phe Thr Leu Ser Phe Cys Gly Tyr Asn Val Ile Ser His 165 170 175 ttc tac tgt gac agt ctc cct ttg tta cct ttg ctt tgt tca aat aca 576 Phe Tyr Cys Asp Ser Leu Pro Leu Leu Pro Leu Leu Cys Ser Asn Thr 180 185 190 cat gaa att gaa ttg ata att ctg atc ttt gca gct att gat ttg att 624 His Glu Ile Glu Leu Ile Ile Leu Ile Phe Ala Ala Ile Asp Leu Ile 195 200 205 tca tct ctt ctg ata gtt ctt tta tct tac ctg ctc atc ctt gta gcc 672 Ser Ser Leu Leu Ile Val Leu Leu Ser Tyr Leu Leu Ile Leu Val Ala 210 215 220 att ctc agg atg aat tct gct ggc aga caa aag gct ttt tct acc tgt 720 Ile Leu Arg Met Asn Ser Ala Gly Arg Gln Lys Ala Phe Ser Thr Cys 225 230 235 240 gga gcc cac ctg aca gtg gtc ata gtg ttc tat ggg act ttg ctt ttc 768 Gly Ala His Leu Thr Val Val Ile Val Phe Tyr Gly Thr Leu Leu Phe 245 250 255 atg tac gtg cag ccc aag tcc agt cat tcc ttt gac act gat aaa gtg 816 Met Tyr Val Gln Pro Lys Ser Ser His Ser Phe Asp Thr Asp Lys Val 260 265 270 gct tcc ata ttt tac acc ctg gtt atc ccc atg ttg aat ccc ttg atc 864 Ala Ser Ile Phe Tyr Thr Leu Val Ile Pro Met Leu Asn Pro Leu Ile 275 280 285 tat agt tta cga aac aaa gat gta aaa tat gcc cta cga agg aca tgg 912 Tyr Ser Leu Arg Asn Lys Asp Val Lys Tyr Ala Leu Arg Arg Thr Trp 290 295 300 aat aac tta tgt aat att ttt gtt taa 939 Asn Asn Leu Cys Asn Ile Phe Val 305 310 <210> 278 <211> 312 <212> PRT <213> Homo sapiens <400> 278 Met Glu Gln His Asn Leu Thr Thr Val Asn Glu Phe Ile Leu Thr Gly 1 5 10 15 Ile Thr Asp Ile Ala Glu Leu Gln Ala Pro Leu Phe Ala Leu Phe Leu 20 25 30 Met Ile Tyr Val Ile Ser Val Met Gly Asn Leu Gly Met Ile Val Leu 35 40 45 Thr Lys Leu Asp Ser Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg 50 55 60 His Leu Ala Phe Met Asp Leu Gly Tyr Ser Thr Thr Val Gly Pro Lys 65 70 75 80 Met Leu Val Asn Phe Val Val Asp Lys Asn Ile Ile Ser Tyr Tyr Phe 85 90 95 Cys Ala Thr Gln Leu Ala Phe Phe Leu Val Phe Ile Gly Ser Glu Leu 100 105 110 Phe Ile Leu Ser Ala Met Ser Tyr Asp Leu Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Thr Val Ile Met Ser Arg Arg Val Cys Gln Val Leu 130 135 140 Val Ala Ile Pro Tyr Leu Tyr Cys Thr Phe Ile Ser Leu Leu Val Thr 145 150 155 160 Ile Lys Ile Phe Thr Leu Ser Phe Cys Gly Tyr Asn Val Ile Ser His 165 170 175 Phe Tyr Cys Asp Ser Leu Pro Leu Leu Pro Leu Leu Cys Ser Asn Thr 180 185 190 His Glu Ile Glu Leu Ile Ile Leu Ile Phe Ala Ala Ile Asp Leu Ile 195 200 205 Ser Ser Leu Leu Ile Val Leu Leu Ser Tyr Leu Leu Ile Leu Val Ala 210 215 220 Ile Leu Arg Met Asn Ser Ala Gly Arg Gln Lys Ala Phe Ser Thr Cys 225 230 235 240 Gly Ala His Leu Thr Val Val Ile Val Phe Tyr Gly Thr Leu Leu Phe 245 250 255 Met Tyr Val Gln Pro Lys Ser Ser His Ser Phe Asp Thr Asp Lys Val 260 265 270 Ala Ser Ile Phe Tyr Thr Leu Val Ile Pro Met Leu Asn Pro Leu Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Asp Val Lys Tyr Ala Leu Arg Arg Thr Trp 290 295 300 Asn Asn Leu Cys Asn Ile Phe Val 305 310 <210> 279 <211> 864 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(864) <400> 279 atg gcc ctc ttt ata cta ttt ctc ctg ata tac cta att act atg ctg 48 M et Ala Leu Phe Ile Leu Phe Leu Leu Ile Tyr Leu Ile Thr Met Leu 1 5 10 15 ggc aat gtg ggg atg ata ttg ata atc cgc ctg gac ctc cag ctt cac 96 Gly Asn Val Gly Met Ile Leu Ile Ile Arg Leu Asp Leu Gln Leu His 20 25 30 act ccc atg tat ttt ttc ctt act cac ttg tca ttt att gac ctc agt 144 Thr Pro Met Tyr Phe Phe Leu Thr His Leu Ser Phe Ile Asp Leu Ser 35 40 45 tac tca act gtc atc aca cct aaa acc tta gcg aac tta ctg act tcc 192 Tyr Ser Thr Val Ile Thr Pro Lys Thr Leu Ala Asn Leu Leu Thr Ser 50 55 60 aac tat att tcc ttc atg ggc tgc ttt gcc cag atg ttc ttt ttt gtc 240 Asn Tyr Ile Ser Phe Met Gly Cys Phe Ala Gln Met Phe Phe Phe Val 65 70 75 80 ttc ttg gga gct gct gaa tgt ttt ctt ctc tca tca atg gcc tat gat 288 Phe Leu Gly Ala Ala Glu Cys Phe Leu Leu Ser Ser Met Ala Tyr Asp 85 90 95 cgc tac gta gct atc tgc agt cct cta cgt tac cca gtt att atg tcc 336 Arg Tyr Val Ala Ile Cys Ser Pro Leu Arg Tyr Pro Val Ile Met Ser 100 105 110 aaa agg ctg tgt tgc gct ctt gtc act ggg ccc tat gtg att agc ttt 384 Lys Arg Leu Cys Cys Ala Leu Val Thr Gly Pro Tyr Val Ile Ser Phe 115 120 125 atc aac tcc ttt gtc aat gtg gtt tgg atg agc aga ctg cat ttc tgc 432 Ile Asn Ser Phe Val Asn Val Val Trp Met Ser Arg Leu His Phe Cys 130 135 140 gac tca aat gta gtt cgt cac ttt ttc tgc gac acg tct cca att tta 480 Asp Ser Asn Val Val Arg His Phe Phe Cys Asp Thr Ser Pro Ile Leu 145 150 155 160 gct ctg tcc tgc atg gac aca tac gac att gaa atc atg ata cac att 528 Ala Leu Ser Cys Met Asp Thr Tyr Asp Ile Glu Ile Met Ile His Ile 165 170 175 tta gct ggt tcc acc ctg atg gtg tcc ctt atc aca ata tct gca tcc 576 Leu Ala Gly Ser Thr Leu Met Val Ser Leu Ile Thr Ile Ser Ala Ser 180 185 190 tat gtg tcc att ctc tct acc atc ctg aaa att aat tcc act tca gga 624 Tyr Val Ser Ile Leu Ser Thr Ile Leu Lys Ile Asn Ser Thr Ser Gly 195 200 205 aag cag aaa gct ttg tct act tgt gcc tct cat ctc ttg gga gtc acc 672 Lys Gln Lys Ala Leu Ser Thr Cys Ala Ser His Leu Leu Gly Val Thr 210 215 220 atc ttt tat gga act atg att ttt act tat tta aaa cca aga aag tct 720 Ile Phe Tyr Gly Thr Met Ile Phe Thr Tyr Leu Lys Pro Arg Lys Ser 225 230 235 240 tat tct ttg gga agg gat caa gtg gct tct gtt ttt tat act att gtg 768 Tyr Ser Leu Gly Arg Asp Gln Val Ala Ser Val Phe Tyr Thr Ile Val 245 250 255 att ccc atg ctg aat cca ctc att tat agt ctt aga aac aaa gaa gtt 816 Ile Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Glu Val 260 265 270 aaa aat gct ctc att aga gtc atg cag aga aga cag gac tcc agg taa 864 Lys Asn Ala Leu Ile Arg Val Met Gln Arg Arg Gln Asp Ser Arg 275 280 285 <210> 280 <211> 287 <212> PRT <213> Homo sapiens <400> 280 Met Ala Leu Phe Ile Leu Phe Leu Leu Ile Tyr Leu Ile Thr Met Leu 1 5 10 15 Gly Asn Val Gly Met Ile Leu Ile Ile Arg Leu Asp Leu Gln Leu His 20 25 30 Thr Pro Met Tyr Phe Phe Leu Thr His Leu Ser Phe Ile Asp Leu Ser 35 40 45 Tyr Ser Thr Val Ile Thr Pro Lys Thr Leu Ala Asn Leu Leu Thr Ser 50 55 60 Asn Tyr Ile Ser Phe Met Gly Cys Phe Ala Gln Met Phe Phe Phe Val 65 70 75 80 Phe Leu Gly Ala Ala Glu Cys Phe Leu Leu Ser Ser Met Ala Tyr Asp 85 90 95 Arg Tyr Val Ala Ile Cys Ser Pro Leu Arg Tyr Pro Val Ile Met Ser 100 105 110 Lys Arg Leu Cys Cys Ala Leu Val Thr Gly Pro Tyr Val Ile Ser Phe 115 120 125 Ile Asn Ser Phe Val Asn Val Val Trp Met Ser Arg Leu His Phe Cys 130 135 140 Asp Ser Asn Val Val Arg His Phe Phe Cys Asp Thr Ser Pro Ile Leu 145 150 155 160 Ala Leu Ser Cys Met Asp Thr Tyr Asp Ile Glu Ile Met Ile His Ile 165 170 175 Leu Ala Gly Ser Thr Leu Met Val Ser Leu Ile Thr Ile Ser Ala Ser 180 185 190 Tyr Val Ser Ile Leu Ser Thr Ile Leu Lys Ile Asn Ser Thr Ser Gly 195 200 205 Lys Gln Lys Ala Leu Ser Thr Cys Ala Ser His Leu Leu Gly Val Thr 210 215 220 Ile Phe Tyr Gly Thr Met Ile Phe Thr Tyr Leu Lys Pro Arg Lys Ser 225 230 235 240 Tyr Ser Leu Gly Arg Asp Gln Val Ala Ser Val Phe Tyr Thr Ile Val 245 250 255 Ile Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Glu Val 260 265 270 Lys Asn Ala Leu Ile Arg Val Met Gln Arg Arg Gln Asp Ser Arg 275 280 285 <210> 281 <211> 960 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(960) <400> 281 atg aat cat gtg gta aaa cac aat cac acg gca gtg acc aag gtg act 48 Met Asn His Val Val Lys His Asn His Thr Ala Val Thr Lys Val Thr 1 5 10 15 gaa ttt att ctc atg ggg att aca gac aac cct ggg ctg cag gct cca 96 Glu Phe Ile Leu Met Gly Ile Thr Asp Asn Pro Gly Leu Gln Ala Pro 20 25 30 ctg ttt gga ctc ttc ctc atc ata tat ctg gtc aca gtg ata ggc aat 144 Leu Phe Gly Leu Phe Leu Ile Ile Tyr Leu Val Thr Val Ile Gly Asn 35 40 45 ctg ggc atg gtt atc ttg acc tac ttg gac tcc aag cta cac acc ccc 192 Leu Gly Met Val Ile Leu Thr Tyr Leu Asp Ser Lys Leu His Thr Pro 50 55 60 atg tac ttt ttc ctt aga cat ttg tca atc act gat ctt ggt tac tcc 240 Met Tyr Phe Phe Leu Arg His Leu Ser Ile Thr Asp Leu Gly Tyr Ser 65 70 75 80 act gtc att gcc ccg aag atg tta gta aac ttc ata gtg cac aaa aac 288 Thr Val Ile Ala Pro Lys Met Leu Val Asn Phe Ile Val His Lys Asn 85 90 95 aca att tct tac aat tgg tat gcc act cag cta gca ttc ttt gag att 336 Thr Ile Ser Tyr Asn Trp Tyr Ala Thr Gln Leu Ala Phe Phe Glu Ile 100 105 110 ttc atc atc tct gag ctc ttt att cta tca gca atg gcc tat gat cgc 384 Phe Ile Ile Ser Glu Leu Phe Ile Leu Ser Ala Met Ala Tyr Asp Arg 115 120 125 tac gta gcc atc tgt aaa cct ctt ctg tac gtg atc atc atg gca gag 432 Tyr Val Ala Ile Cys Lys Pro Leu Leu Tyr Val Ile Ile Met Ala Glu 130 135 140 aaa gta ctt tgg gtg ctg gta att gtt ccc tat ctc tat agc acg ttt 480 Lys Val Leu Trp Val Leu Val Ile Val Pro Tyr Leu Tyr Ser Thr Phe 145 150 155 160 gtg tca cta ttt ctc aca att aag tta ttt aaa ctg tcc ttc tgt ggc 528 Val Ser Leu Phe Leu Thr Ile Lys Leu Phe Lys Leu Ser Phe Cys Gly 165 170 175 tca aac ata atc agc tat ttt tac tgt gac tgt atc cct ctg atg tcc 576 Ser Asn Ile Ile Ser Tyr Phe Tyr Cys Asp Cys Ile Pro Leu Met Ser 180 185 190 ata ctc tgt tct gac aca aat gaa tta gaa tta ata att ttg atc ttc 624 Ile Leu Cys Ser Asp Thr Asn Glu Leu Glu Leu Ile Ile Leu Ile Phe 195 200 205 tca ggc tgt aat ttg ctc ttc tcc ctc tca att gtt ctc ata tcc tac 672 Ser Gly Cys Asn Leu Leu Phe Ser Leu Ser Ile Val Leu Ile Ser Tyr 210 215 220 atg ttt att cta gtg gcc att ctc aga atg aac tca agg aaa ggg agg 720 Met Phe Ile Leu Val Ala Ile Leu Arg Met Asn Ser Arg Lys Gly Arg 225 230 235 240 tac aaa gcc ttc tcc acc tgt agc tct cat ctg aca gtg gtg atc atg 768 Tyr Lys Ala Phe Ser Thr Cys Ser Ser His Leu Thr Val Val Ile Met 245 250 255 ttc tat ggg aca ttg tta ttt att tac ttg caa ccc aag tcc agt cat 816 Phe Tyr Gly Thr Leu Leu Phe Ile Tyr Leu Gln Pro Lys Ser Ser His 260 265 270 act ttg gct att gat aaa atg gcc tca gtg ttt tat acc ctg ttg att 864 Thr Leu Ala Ile Asp Lys Met Ala Ser Val Phe Tyr Thr Leu Leu Ile 275 280 285 cct atg ctg aat ccg ttg atc tac agc cta agg aac aaa gaa gta aaa 912 Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys 290 295 300 gat gct cta aag aga act tta acc aat cga ttc aaa att ccc att taa 960 Asp Ala Leu Lys Arg Thr Leu Thr Asn Arg Phe Lys Ile Pro Ile 305 310 315 320 <210> 282 <211> 319 <212> PRT <213> Homo sapiens <400> 282 Met Asn His Val Val Lys His Asn His Thr Ala Val Thr Lys Val Thr 1 5 10 15 Glu Phe Ile Leu Met Gly Ile Thr Asp Asn Pro Gly Leu Gln Ala Pro 20 25 30 Leu Phe Gly Leu Phe Leu Ile Ile Tyr Leu Val Thr Val Ile Gly Asn 35 40 45 Leu Gly Met Val Ile Leu Thr Tyr Leu Asp Ser Lys Leu His Thr Pro 50 55 60 Met Tyr Phe Phe Leu Arg His Leu Ser Ile Thr Asp Leu Gly Tyr Ser 65 70 75 80 Thr Val Ile Ala Pro Lys Met Leu Val Asn Phe Ile Val His Lys Asn 85 90 95 Th r Ile Ser Tyr Asn Trp Tyr Ala Thr Gln Leu Ala Phe Phe Glu Ile 100 105 110 Phe Ile Ile Ser Glu Leu Phe Ile Leu Ser Ala Met Ala Tyr Asp Arg 115 120 125 Tyr Val Ala Ile Cys Lys Pro Leu Leu Tyr Val Ile Ile Met Ala Glu 130 135 140 Lys Val Leu Trp Val Leu Val Ile Val Pro Tyr Leu Tyr Ser Thr Phe 145 150 155 160 Val Ser Leu Phe Leu Thr Ile Lys Leu Phe Lys Leu Ser Phe Cys Gly 165 170 175 Ser Asn Ile Ile Ser Tyr Phe Tyr Cys Asp Cys Ile Pro Leu Met Ser 180 185 190 Ile Leu Cys Ser Asp Thr Asn Glu Leu Glu Leu Ile Ile Leu Ile Phe 195 200 205 Ser Gly Cys Asn Leu Leu Phe Ser Leu Ser Ile Val Leu Ile Ser Tyr 210 215 220 Met Phe Ile Leu Val Ala Ile Leu Arg Met Asn Ser Arg Lys Gly Arg 225 230 235 240 Tyr Lys Ala Phe Ser Thr Cys Ser Ser His Leu Thr Val Val Ile Met 245 250 255 Phe Tyr Gly Thr Leu Leu Phe Ile Tyr Leu Gln Pro Lys Ser Ser His 260 265 270 Thr Leu Ala Ile Asp Lys Met Ala Ser Val Phe Tyr Thr Leu Leu Ile 275 280 285 Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys 290 295 300 Asp Ala Leu Lys Arg Thr Leu Thr Asn Arg Phe Lys Ile Pro Ile 305 310 315 <210> 283 <211> 951 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(951) <400> 283 atg gct cct gaa aat ttc acc aga gtc act gag ttt att ctt aca ggt 48 Met Ala Pro Glu Asn Phe Thr Arg Val Thr Glu Phe Ile Leu Thr Gly 1 5 10 15 gtc tct agc tgt cca gag ctc cag att ccc ctc ttc ctg gtc ttt ctg 96 Val Ser Ser Cys Pro Glu Leu Gln Ile Pro Leu Phe Leu Val Phe Leu 20 25 30 gtg ctc tat ggg ctg acc atg gca ggg aac ctg ggc atc atc acc ctc 144 Val Leu Tyr Gly Leu Thr Met Ala Gly Asn Leu Gly Ile Ile Thr Leu 35 40 45 acc agt gtt gac tct cga ctt caa acc ccc atg tac ttt ttc ctg caa 192 Thr Ser Val Asp Ser Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu Gln 50 55 60 cat ctg gct ctc att aat ctt ggt aac tct act gtc att gcc cct aaa 240 His Leu Ala Leu Ile Asn Leu Gly Asn Ser Thr Val Ile Ala Pro Lys 65 70 75 80 atg ctg att aac ttt tta gta aag aag aaa act acc tca ttc tat gaa 288 Met Leu Ile Asn Phe Leu Val Lys Lys Lys Thr Thr Ser Phe Tyr Glu 85 90 95 tgt gcc acc caa ctg gga ggg ttc ttg ttc ttt att gta tcg gag gta 336 Cys Ala Thr Gln Leu Gly Gly Phe Leu Phe Phe Ile Val Ser Glu Val 100 105 110 atc atg ctg gct ttg atg gcc tat gac cgc tat gtg gct att tgt aac 384 Ile Met Leu Ala Leu Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 cct ctg ctg tac atg gtg gtg gtg tct cgg cgg ctc tgc ctc ctg ctg 432 Pro Leu Leu Tyr Met Val Val Val Ser Arg Arg Leu Cys Leu Leu Leu 130 135 140 gtc tcc ctc aca tac ctc tat ggc ttt tct aca gct att gtg gtt tca 480 Val Ser Leu Thr Tyr Leu Tyr Gly Phe Ser Thr Ala Ile Val Val Ser 145 150 155 160 tct tat gta ttc tct gtg tct tat tgc tct tct aat ata atc aat cat 528 Ser Tyr Val Phe Ser Val Ser Tyr Cys Ser Ser Asn Ile Ile Asn His 165 170 175 ttt tac tgt gat aat gtt cct ctg tta gca tta tct tgc tct gat act 576 Phe Tyr Cys Asp Asn Val Pro Leu Leu Ala Leu Ser Cys Ser Asp Thr 180 185 190 tac tta cca gaa aca gtt gtc ttt ata tct gca gca aca aat gtg gtt 624 Tyr Leu Pro Glu Thr Val Val Phe Ile Ser Ala Ala Thr Asn Val Val 195 200 205 ggt tcc ttg att ata gtt cta gta tct tat ttc aat att gtt ttg tct 672 Gly Ser Leu Ile Ile Val Leu Val Ser Tyr Phe Asn Ile Val Leu Ser 210 215 220 att tta aaa ata tgt tca tca gaa gga agg aaa aaa gcc ttt tct acc 720 Ile Leu Lys Ile Cys Ser Ser Glu Gly Arg Lys Lys Ala Phe Ser Thr 225 230 235 240 tgt gct tca cat atg atg gca gtc aca att ttt tat ggg aca ttg cta 768 Cys Ala Ser His Met Met Ala Val Thr Ile Phe Tyr Gly Thr Leu Leu 245 250 255 ttc atg tat gtg cag ccc cga agt aac cat tca ctg gat act gat gat 816 Phe Met Tyr Val Gln Pro Arg Ser Asn His Ser Leu Asp Thr Asp Asp 260 265 270 aag atg gct tct gtg ttt tac acg ttg gta att cct atg ctg aat ccc 864 Lys Met Ala Ser Val Phe Tyr Thr Leu Val Ile Pro Met Leu Asn Pro 275 280 285 ttg atc tac agc ctg agg aat aag gat gtg aag act gct cta cag aga 912 Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Thr Ala Leu Gln Arg 290 295 300 ttc atg aca aat ctg tgc tat tcc ttt aaa aca atg taa 951 Phe Met Thr Asn Leu Cys Tyr Ser Phe Lys Thr Met 305 310 315 <210> 284 <211> 316 <212> PRT <213> Homo sapiens <400> 284 Met Ala Pro Glu Asn Phe Thr Arg Val Thr Glu Phe Ile Leu Thr Gly 1 5 10 15 Val Ser Ser Cys Pro Glu Leu Gln Ile Pro Leu Phe Leu Val Phe Leu 20 25 30 Val Leu Tyr Gly Leu Thr Met Ala Gly Asn Leu Gly Ile Ile Thr Leu 35 40 45 Thr Ser Val Asp Ser Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu Gln 50 55 60 His Leu Ala Leu Ile Asn Leu Gly Asn Ser Thr Val Ile Ala Pro Lys 65 70 75 80 Met Leu Ile Asn Phe Leu Val Lys Lys Lys Thr Thr Ser Phe Tyr Glu 85 90 95 Cys Ala Thr Gln Leu Gly Gly Phe Leu Phe Phe Ile Val Ser Glu Val 100 105 110 Ile Met Leu Ala Leu Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Met Val Val Val Ser Arg Arg Leu Cys Leu Leu Leu 130 135 140 Val Ser Leu Thr Tyr Leu Tyr Gly Phe Ser Thr Ala Ile Val Val Ser 145 150 155 160 Ser Tyr Val Phe Ser Val Ser Tyr Cys Ser Ser Asn Ile Ile Asn His 165 170 175 Phe Tyr Cys Asp Asn Val Pro Leu Leu Ala Leu Ser Cys Ser Asp Thr 180 185 190 Tyr Leu Pro Glu Thr Val Val Phe Ile Ser Ala Ala Thr Asn Val Val 195 200 205 Gly Ser Leu Ile Ile Val Leu Val Ser Tyr Phe Asn Ile Val Leu Ser 210 215 220 Ile Leu Lys Ile Cys Ser Ser Glu Gly Arg Lys Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Met Met Ala Val Thr Ile Phe Tyr Gly Thr Leu Leu 245 250 255 Phe Met Tyr Val Gln Pro Arg Ser Asn His Ser Leu Asp Thr Asp Asp 260 265 270 Lys Met Ala Ser Val Phe Tyr Thr Leu Val Ile Pro Met Leu Asn Pro 275 280 285 Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Thr Ala Leu Gln Arg 290 295 300 Phe Met Thr Asn Leu Cys Tyr Ser Phe Lys Thr Met 305 310 315 <210> 285 <211> 930 <212> DNA <2 13> Homo sapiens <220> <221> CDS <222> (1)..(930) <400> 285 atg gca aat ctc aca atc gtg act gaa ttt atc ctt atg ggg ttt tct 48 Met Ala Asn Leu Thr Ile Val Thr Glu Phe Ile Leu Met Gly Phe Ser 1 5 10 15 acc aat aaa aat atg tgc att ttg cat tcg att ctc ttc ttg ttg att 96 Thr Asn Lys Asn Met Cys Ile Leu His Ser Ile Leu Phe Leu Leu Ile 20 25 30 tat ttg tgt gcc ctg atg ggg aat gtc ctc att atc atg atc aca act 144 Tyr Leu Cys Ala Leu Met Gly Asn Val Leu Ile Ile Met Ile Thr Thr 35 40 45 ttg gac cat cat ctc cac acc ccc gtg tat ttc ttc ttg aag aat cta 192 Leu Asp His His Leu His Thr Pro Val Tyr Phe Phe Leu Lys Asn Leu 50 55 60 tct ttc ttg gat ctc tgc ctt att tca gtc acg gct ccc aaa tct atc 240 Ser Phe Leu Asp Leu Cys Leu Ile Ser Val Thr Ala Pro Lys Ser Ile 65 70 75 80 gcc aat tct ttg ata cac aac aac tcc att tca ttc ctt ggc tgt gtt 288 Ala Asn Ser Leu Ile His Asn Asn Ser Ile Ser Phe Leu Gly Cys Val 85 90 95 tcc cag gtc ttt ttg ttg ctt tct tca gca tct gca gag ctg ctc ctc 336 Ser Gln Val Phe Leu Leu Leu Ser Ser Ala Ser Ala Glu Leu Leu Leu 100 105 110 ctc acg gtg atg tcc ttt gac cgc tat act gct ata tgt cac cct ctg 384 Leu Thr Val Met Ser Phe Asp Arg Tyr Thr Ala Ile Cys His Pro Leu 115 120 125 cac tat gat gtc atc atg gac agg agc acc tgt gtc caa aga gcc act 432 His Tyr Asp Val Ile Met Asp Arg Ser Thr Cys Val Gln Arg Ala Thr 130 135 140 gtg tct tgg ctg tat ggg ggt ctg att gct gtg atg cac aca gct ggc 480 Val Ser Trp Leu Tyr Gly Gly Leu Ile Ala Val Met His Thr Ala Gly 145 150 155 160 acc ttc tcc tta tcc tac tgt ggg tcc aac atg gtc cat cag ttc ttc 528 Thr Phe Ser Leu Ser Tyr Cys Gly Ser Asn Met Val His Gln Phe Phe 165 170 175 tgt gac att ccc cag tta tta gct att tct tgc tca gaa aat tta ata 576 Cys Asp Ile Pro Gln Leu Leu Ala Ile Ser Cys Ser Glu Asn Leu Ile 180 185 190 aga gaa att gca ctc atc ctt att aat gta gtt ttg gat ttc tgc tgt 624 Arg Glu Ile Ala Leu Ile Leu Ile Asn Val Val Leu Asp Phe Cys Cys 195 200 205 ttt att gtc atc atc att acc tat gtc cac gtc ttc tct aca gtc aag 672 Phe Ile Val Ile Ile Ile Thr Tyr Val His Val Phe Ser Thr Val Lys 210 215 220 aag atc cct tcc aca gaa ggc cag tca aaa gcc tac tct att tgc ctt 720 Lys Ile Pro Ser Thr Glu Gly Gln Ser Lys Ala Tyr Ser Ile Cys Leu 225 230 235 240 cca cac ttg ctg gtt gtg tta ttt ctt tcc act gga ttc att gct tat 768 Pro His Leu Leu Val Val Leu Phe Leu Ser Thr Gly Phe Ile Ala Tyr 245 250 255 ctg aag cca gct tca gag tct cct tct att ttg gat gct gta att tct 816 Leu Lys Pro Ala Ser Glu Ser Pro Ser Ile Leu Asp Ala Val Ile Ser 260 265 270 gtg ttc tac act atg ctg ccc cca acc ttt aat ccc att ata tac agt 864 Val Phe Tyr Thr Met Leu Pro Pro Thr Phe Asn Pro Ile Ile Tyr Ser 275 280 285 ttg aga aac aag gcc ata aag gtg gct ctg ggg atg ttg ata aag gga 912 Leu Arg Asn Lys Ala Ile Lys Val Ala Leu Gly Met Leu Ile Lys Gly 290 295 300 aag ctc acc aaa aag taa 930 Lys Leu Thr Lys Lys 305 310 <210> 286 <211> 309 <212> PRT <213> Homo sapiens <400> 286 Met Ala Asn Leu Thr Ile Val Thr Glu Phe Ile Leu Met Gly Phe Ser 1 5 10 15 Thr Asn Lys Asn Met Cys Ile Leu His Ser Ile Leu Phe Leu Leu Ile 20 25 30 Tyr Leu Cys Ala Leu Met Gly Asn Val Leu Ile Ile Met Ile Thr Thr 35 40 45 Leu Asp His His Leu His Thr Pro Val Tyr Phe Phe Leu Lys Asn Leu 50 55 60 Ser Phe Leu Asp Leu Cys Leu Ile Ser Val Thr Ala Pro Lys Ser Ile 65 70 75 80 Ala Asn Ser Leu Ile His Asn Asn Ser Ile Ser Phe Leu Gly Cys Val 85 90 95 Ser Gln Val Phe Leu Leu Leu Ser Ser Ala Ser Ala Glu Leu Leu Leu 100 105 110 Leu Thr Val Met Ser Phe Asp Arg Tyr Thr Ala Ile Cys His Pro Leu 115 120 125 His Tyr Asp Val Ile Met Asp Arg Ser Thr Cys Val Gln Arg Ala Thr 130 135 140 Val Ser Trp Leu Tyr Gly Gly Leu Ile Ala Val Met His Thr Ala Gly 145 150 155 160 Thr Phe Ser Leu Ser Tyr Cys Gly Ser Asn Met Val His Gln Phe Phe 165 170 175 Cys Asp Ile Pro Gln Leu Leu Ala Ile Ser Cys Ser Glu Asn Leu Ile 180 185 190 Arg Glu Ile Ala Leu Ile Leu Ile Asn Val Val Leu Asp Phe Cys Cys 195 200 205 Phe Ile Val Ile Ile Ile Thr Tyr Val His Val Phe Ser Thr Val Lys 210 215 220 Lys Ile Pro Ser Thr Glu Gly Gln Ser Lys Ala Tyr Ser Ile Cys Leu 225 230 235 240 Pro His Leu Leu Val Val Leu Phe Leu Ser Thr Gly Phe Ile Ala Tyr 245 250 255 Leu Lys Pro Ala Ser Glu Ser Pro Ser Ile Leu Asp Ala Val Ile Ser 260 265 270 Val Phe Tyr Thr Met Leu Pro Pro Thr Phe Asn Pro Ile Ile Tyr Ser 275 280 285 Leu Arg Asn Lys Ala Ile Lys Val Ala Leu Gly Met Leu Ile Lys Gly 290 295 300 Lys Leu Thr Lys Lys 305 <210> 287 <211> 1143 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1143) <400> 287 atg aag aca gaa tat cat gaa cac aag atg tca ttg gaa agc att caa 48 Met Lys Thr Glu Tyr His Glu His Lys Met Ser Leu Glu Ser Ile Gln 1 5 10 15 gca agc aag ttt gga tgc tac tta cct gcg cac gca tgc aca cac aca 96 Ala Ser Lys Phe Gly Cys Tyr Leu Pro Ala His Ala Cys Thr His Thr 20 25 30 cac aca cac aca cac aca cac tgt ctc tct ctc atg aat aag aga ctt 144 His Thr His Thr His Thr His Cys Leu Ser Leu Met Asn Lys Arg Leu 35 40 45 aac act gct ggc ttt tac aat tta ata act tat ttt tct aga ttt gtt 192 Asn Thr Ala Gly Phe Tyr Asn Leu Ile Thr Tyr Phe Ser Arg Phe Val 50 55 60 ggg aat atg gaa aaa aga aat cta aca gtt gtc agg gaa ttc gtc ctt 240 Gly Asn Met Glu Lys Arg Asn Leu Thr Val Val Arg Glu Phe Val Leu 65 70 75 80 ctg gga ctt cct agc tca gca gag cag cag cac ctc ctg tct gtg ctc 288 Leu Gly Leu Pro Ser Ser Ala Glu Gln Gln His Leu Leu Ser Val Leu 85 90 95 ttt ctc tgt atg tat tta gcc acc acc ttg ggg aac atg ctc atc att 336 Phe Leu Cys Met Tyr Leu Ala Thr Thr Leu Gly Asn Met Leu Ile Ile 100 105 110 gcg acg att ggc ttt gac tct cac ctc cat tcc cct atg tac ttc ttc 384 Ala Thr Ile Gly Phe Asp Ser His Leu His Ser Pro Met Tyr Phe Phe 115 120 125 ctt agt aac ttg gcc ttt gtt gac atc tgc ttt acg tcg act aca gtc 432 Leu Ser Asn Leu Ala Phe Val Asp Ile Cys Phe Thr Ser Thr Thr Val 130 135 140 ccc caa atg gta gtg aat atc ttg act ggc acc aag act atc tct ttt 480 Pro Gln Met Val Val Asn Ile Leu Thr Gly Thr Lys Thr Ile Ser Phe 145 150 155 160 gca ggc tgc ctc acc cag ctc ttc ttc ttc gtt tct ttt gtg aat atg 528 Ala Gly Cys Leu Thr Gln Leu Phe Phe Phe Val Ser Phe Val Asn Met 165 170 175 gac agc ctc ctt ctg tgt gtg atg gcg tat gat aga tat gtg gcg att 576 Asp Ser Leu Leu Leu Cys Val Met Ala Tyr Asp Arg Tyr Val Ala Ile 180 185 190 tgc cac ccc tta cat tac acc gcc aga atg aac ctg tgc ctt tgt gtc 624 Cys His Pro Leu His Tyr Thr Ala Arg Met Asn Leu Cys Leu Cys Val 195 200 205 cag cta gtg gct gga ctg tgg ctt gtt act tac ctc cac gcc ctc ctg 672 Gln Leu Val Ala Gly Leu Trp Leu Val Thr Tyr Leu His Ala Leu Leu 210 215 220 cat act gtc cta ata gca cag ctg tcc ttc tgt gcc tcc aat atc atc 720 His Thr Val Leu Ile Ala Gln Leu Ser Phe Cys Ala Ser Asn Ile Ile 225 230 235 240 cat cat ttc ttc tgt gat ctc aat cct ctc ctg cag ctc tct tgc tct 768 His His Phe Phe Cys Asp Leu Asn Pro Leu Leu Gln Leu Ser Cys Ser 245 250 255 gac gtc tcc ttc aat gta atg atc att ttt gca gta gga ggt cta ttg 816 Asp Val Ser Phe Asn Val Met Ile Ile Phe Ala Val Gly Gly Leu Leu 260 265 270 gct ctc acg ccc ctt gtc tgt atc ctc gta tct tat gga ctt atc ttc 864 Ala Leu Thr Pro Leu Val Cys Ile Leu Val Ser Tyr Gly Leu Ile Phe 275 280 285 tcc act gtt ctg aag atc acc tct act cag ggc aag cag aga gct gtt 912 Ser Thr Val Leu Lys Ile Thr Ser Thr Gln Gly Lys Gln Arg Ala Val 290 295 300 tcc acc tgc agc tgc cac ctg tca gtg gtg gtg ttg ttt tac ggc aca 960 Ser Thr Cys Ser Cys His Leu Ser Val Val Val Leu Phe Tyr Gly Thr 305 310 315 320 gcc atc gcc gtc tat ttc agc cct tca tcc ccc cat atg cct gag agc 1008 Ala Ile Ala Val Tyr Phe Ser Pro Ser Ser Pro His Met Pro Glu Ser 325 330 335 gac act ctg tca acc atc atg tat tca atg gtg gct ccg atg ctg aat 1056 Asp Thr Leu Ser Thr Ile Met Tyr Ser Met Val Ala Pro Met Leu Asn 340 345 350 cct ttc atc tat acc cta agg aac agg gat atg aag agg gga ctt cag 1104 Pro Phe Ile Tyr Thr Leu Arg Asn Arg Asp Met Lys Arg Gly Leu Gln 355 360 365 aaa atg ctt ctc aag tgc aca gtc ttt cag cag caa taa 1143 Lys Met Leu Leu Lys Cys Thr Val Phe Gln Gln Gln 370 375 380 <210> 288 <211> 380 <212> PRT <213> Homo sapiens <400> 288 Met Lys Thr Glu Tyr His Glu His Lys Met Ser Leu Glu Ser Ile Gln 1 5 10 15 Ala Ser Lys Phe Gly Cys Tyr Leu Pro Ala His Ala Cys Thr His Thr 20 25 30 His Thr His Thr His Thr His Cys Leu Ser Leu Met Asn Lys Arg Leu 35 40 45 Asn Thr Ala Gly Phe Tyr Asn Leu Ile Thr Tyr Phe Ser Arg Phe Val 50 55 60 Gly Asn Met Glu Lys Arg Asn Leu Thr Val Val Arg Glu Phe Val Leu 65 70 75 80 Leu Gly Leu Pro Ser Ser Ala Glu Gln Gln His Leu Leu Ser Val Leu 85 90 95 Phe Leu Cys Met Tyr Leu Ala Thr Thr Leu Gly Asn Met Leu Ile Ile 100 105 110 Ala Thr Ile Gly Phe Asp Ser His Leu His Ser Pro Met Tyr Phe Phe 115 120 125 Leu Ser Asn Leu Ala Phe Val Asp Ile Cys Phe Thr Ser Thr Thr Val 130 135 140 Pro Gln Met Val Val Asn Ile Leu Thr Gly Thr Lys Thr Ile Ser Phe 145 150 155 160 Ala Gly Cys Leu Thr Gln Leu Phe Phe Phe Val Ser Phe Val Asn Met 165 170 175 Asp Ser Leu Leu Leu Cys Val Met Ala Tyr Asp Arg Tyr Val Ala Ile 180 185 190 Cys His Pro Leu His Tyr Thr Ala Arg Met Asn Leu Cys Leu Cys Val 195 200 205 Gln Leu Val Ala Gly Leu Trp Leu Val Thr Tyr Leu His Ala Leu Leu 210 215 220 His Thr Val Leu Ile Ala Gln Leu Ser Phe Cys Ala Ser Asn Ile Ile 225 230 235 240 His His Phe Phe Cys Asp Leu Asn Pro Leu Leu Gln Leu Ser Cys Ser 245 250 255 Asp Val Ser Phe Asn Val Met Ile Ile Phe Ala Val Gly Gly Leu Leu 260 265 270 Ala Leu Thr Pro Leu Val Cys Ile Leu Val Ser Tyr Gly Leu Ile Phe 275 280 285 Ser Thr Val Leu Lys Ile Thr Ser Thr Gln Gly Lys Gln Arg Ala Val 290 295 300 Ser Thr Cys Ser Cys His Leu Ser Val Val Val Leu Phe Tyr Gly Thr 305 310 315 320 Ala Ile Ala Val Tyr Phe Ser Pro Ser Ser Pro His Met Pro Glu Ser 325 330 335 Asp Thr Leu Ser Thr Ile Met Tyr Ser Met Val Ala Pro Met Leu Asn 340 345 350 Pro Phe Ile Tyr Thr Leu Arg Asn Arg Asp Met Lys Arg Gly Leu Gln 355 360 365 Lys Met Leu Leu Lys Cys Thr Val Phe Gln Gln Gln 370 375 380 <210> 289 <211> 765 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(765) <400> 289 atg tat ttt ttc ttc tcc aac cta agc ttt ttg gat ctg tgt tac aca 48 Met Tyr Phe Phe Phe Ser Asn Leu Ser Phe Leu Asp Leu Cys Tyr Thr 1 5 10 15 acc ggc att gtt cca cag ctc ctg gtt aat ctc agg gga gca gac aaa 96 Thr Gly Ile Val Pro Gln Leu Leu Val Asn Leu Arg Gly Ala Asp Lys 20 25 30 tca atc tcc tat ggt ggt tgt gta gtt cag ctg tac atc tct cta ggc 144 Ser Ile Ser Tyr Gly Gly Cys Val Val Gln Leu Tyr Ile Ser Leu Gly 35 40 45 ttg gga tct aca gaa tgc gtt ctc tta gga gtg atg gca ttt gac cgc 192 Leu Gly Ser Thr Glu Cys Val Leu Leu Gly Val Met Ala Phe Asp Arg 50 55 60 tat gca gct gtt tgc agg ccc ctc cac tac aca gta gtc atg cac cct 240 Tyr Ala Ala Val Cys Arg Pro Leu His Tyr Thr Val Val Met His Pro 65 70 75 80 tgt ctg tat gtg ctg atg gct tct act tca tgg gtc att ggt ttt gcc 288 Cys Leu Tyr Val Leu Met Ala Ser Thr Ser Trp Val Ile Gly Phe Ala 85 90 95 aac tcc cta ttg cag acg gtg ctc atc ttg ctt tta aca ctt tgt gga 336 Asn Ser Leu Leu Gln Thr Val Leu Ile Leu Leu Leu Thr Leu Cys Gly 100 105 110 aga aat aaa tta gaa cac ttt ctt tgt gag gtt cct cca ttg ctc aag 384 Arg Asn Lys Leu Glu His Phe Leu Cys Glu Val Pro Pro Leu Leu Lys 115 120 125 ctt gcc tgt gtt gac act act atg aat gaa tct gaa ctc ttc ttt gtc 432 Leu Ala Cys Val Asp Thr Thr Met Asn Glu Ser Glu Leu Phe Phe Val 130 135 140 agt gtc att att ctt ctt gta cct gtt gca tta atc ata ttc tcc tat 480 Ser Val Ile Ile Leu Leu Val Pro Val Ala Leu Ile Ile Phe Ser Tyr 145 150 155 160 agt cag att gtc agg gca gtc gtg agg ata aag tca gca aca ggg cag 528 Ser Gln Ile Val Arg Ala Val Val Arg Ile Lys Ser Ala Thr Gly Gln 165 170 175 aga aaa gtg ttt ggg aca tgt ggc tcc cac ctc aca gtg gtt tcc ctg 576 Arg Lys Val Phe Gly Thr Cys Gly Ser His Leu Thr Val Val Ser Leu 180 185 190 ttc tac ggc aca gct atc tat gct tac ctc cag ccc ggc aac aac tac 624 Phe Tyr Gly Thr Ala Ile Tyr Ala Tyr Leu Gln Pro Gly Asn Asn Tyr 195 200 205 tct cag gat cag ggc aag ttc atc tct ctc ttc tac acc atc att aca 672 Ser Gln Asp Gln Gly Lys Phe Ile Ser Leu Phe Tyr Thr Ile Ile Thr 210 215 220 ccc atg atc aac ccc ctc ata tat aca ctg agg aac aag gat gtg aaa 720 Pro Met Ile Asn Pro Leu Ile Tyr Thr Leu Arg Asn Lys Asp Val Lys 225 230 235 240 gga gca ctt aag aag gtg ctc tgg aag aac tac gac tcc aga tga 765 Gly Ala Leu Lys Lys Val Leu Trp Lys Asn Tyr Asp Ser Arg 245 250 255 <210> 290 <211> 254 <212> PRT <213> Homo sapiens <400> 290 Met Tyr Phe Phe Phe Ser Asn Leu Ser Phe Leu Asp Leu Cys Tyr Thr 1 5 10 15 Thr Gly Ile Val Pro Gln Leu Leu Val Asn Leu Arg Gly Ala Asp Lys 20 25 30 Ser Ile Ser Tyr Gly Gly Cys Val Val Gln Leu Tyr Ile Ser Leu Gly 35 40 45 Leu Gly Ser Thr Glu Cys Val Leu Leu Gly Val Met Ala Phe Asp Arg 50 55 60 Tyr Ala Ala Val Cys Arg Pro Leu His Tyr Thr Val Val Met His Pro 65 70 75 80 Cys Leu Tyr Val Leu Met Ala Ser Thr Ser Trp Val Ile Gly Phe Ala 85 90 95 Asn Ser Leu Leu Gln Thr Val Leu Ile Leu Leu Leu Thr Leu Cys Gly 100 105 110 Arg Asn Lys Leu Glu His Phe Leu Cys Glu Val Pro Pro Leu Leu Lys 115 120 125 Leu Ala Cys Val Asp Thr Thr Met Asn Glu Ser Glu Leu Phe Phe Val 130 135 140 Ser Val Ile Ile Leu Leu Val Pro Val Ala Leu Ile Ile Phe Ser Tyr 145 150 155 160 Ser Gln Ile Val Arg Ala Val Val Arg Ile Lys Ser Ala Thr Gly Gln 165 170 175 Arg Lys Val Phe Gly Thr Cys Gly Ser His Leu Thr Val Val Ser Leu 180 185 190 Phe Tyr Gly Thr Ala Ile Tyr Ala Tyr Leu Gln Pro Gly Asn Asn Tyr 195 200 205 Ser Gln Asp Gln Gly Lys Phe Ile Ser Leu Phe Tyr Thr Ile Ile Thr 210 215 220 Pro Met Ile Asn Pro Leu Ile Tyr Thr Leu Arg Asn Lys Asp Val Lys 225 230 235 240 Gly Ala Leu Lys Lys Val Leu Trp Lys Asn Tyr Asp Ser Arg 245 250 <210> 291 <211> 954 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(954) <400> 291 atg caa cca tat acc aaa aac tgg acc cag gta act gaa ttt gtc atg 48 Met Gln Pro Tyr Thr Lys Asn Trp Thr Gln Val Thr Glu Phe Val Met 1 5 10 15 atg ggc ttt gct ggc atc cat gaa gca cac ctc ctc ttc ttc ata ctc 96 Met Gly Phe Ala Gly Ile His Glu Ala His Leu Leu Phe Phe Ile Leu 20 25 30 ttc ctc acc atg tac ctg ttc acc ttg gtg gag aat ttg gcc atc att 144 Phe Leu Thr Met Tyr Leu Phe Thr Leu Val Glu Asn Leu Ala Ile Ile 35 40 45 tta gtg gtg ggt ttg gac cac cga cta cgg aga ccc atg tat ttc ttc 192 Leu Val Val Gly Leu Asp His Arg Leu Arg Arg Pro Met Tyr Phe Phe 50 55 60 ctg aca cac ttg tcc tgc ctt gaa atc tgg tac act tct gtt aca gtg 240 Leu Thr His Leu Ser Cys Leu Glu Ile Trp Tyr Thr Ser Val Thr Val 65 70 75 80 ccc aag atg ctg gct ggt ttt att ggg gtg gat ggt ggc aag aat atc 288 Pro Lys Met Leu Ala Gly Phe Ile Gly Val Asp Gly Gly Lys Asn Ile 85 90 95 tct tat gct ggt tgc cta tcc cag ctc ttc atc ttc acc ttt ctt ggg 336 Ser Tyr Ala Gly Cys Leu Ser Gln Leu Phe Ile Phe Thr Phe Leu Gly 100 105 110 gca act gag tgt ttc cta ctg gct gcc atg gcc tat gat cgt tat gtg 384 Ala Thr Glu Cys Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val 115 120 125 gcc att tgt atg cct ctc cac tat ggg gct ttt gtg tcc tgg ggc acc 432 Ala Ile Cys Met Pro Leu His Tyr Gly Ala Phe Val Ser Trp Gly Thr 130 135 140 tgc atc cgt ctg gca gct gcc tgt tgg ctg gta ggt ttc ctc aca ccc 480 Cys Ile Arg Leu Ala Ala Ala Cys Trp Leu Val Gly Phe Leu Thr Pro 145 150 155 160 atc ttg cca atc tac ctc ttg tct cag cta aca ttt tgt ggc cca aat 528 Ile Leu Pro Ile Tyr Leu Leu Ser Gln Leu Thr Phe Cys Gly Pro Asn 165 170 175 gtc att gac cat ttc tcc tgt gat gcc tca ccc ttg cta gcc ttg tcg 576 Val Ile Asp His Phe Ser Cys Asp Ala Ser Pro Leu Leu Ala Leu Ser 180 185 190 tgc tca gat gtc act tgg aag gag act gtg gat ttc ctg gtg tct ctg 624 Cys Ser Asp Val Thr Trp Lys Glu Thr Val Asp Phe Leu Val Ser Leu 195 200 205 gct gtg cta ctg gcc tcc tct atg gtc att gct gtg tcc tat ggc aac 672 Ala Val Leu Leu Ala Ser Ser Met Val Ile Ala Val Ser Tyr Gly Asn 210 215 220 atc gtc tgg aca ctg ctg cac atc cgc tca gct gct gag cgc tgg aag 720 Ile Val Trp Thr Leu Leu His Ile Arg Ser Ala Ala Glu Arg Trp Lys 225 230 235 240 gcc ttc tct acc tgt gca gct cac ctg act gtg gtg agc ctc ttc tat 768 Ala Phe Ser Thr Cys Ala Ala His Leu Thr Val Val Ser Leu Phe Tyr 245 250 255 ggc act ctt ttc ttt atg tat gtc cag acc aag gtg acc tcc tcc atc 816 Gly Thr Leu Phe Phe Met Tyr Val Gln Thr Lys Val Thr Ser Ser Ile 260 265 270 aac ttc aac aag gtg gta tct gtc ttc tac tct gtt gtc acg ccc atg 864 Asn Phe Asn Lys Val Val Ser Val Phe Tyr Ser Val Val Thr Pro Met 275 280 285 ctc aat cct ctc atc tac agt ctt agg aac aag gaa gtg aag gga gct 912 Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Gly Ala 290 295 300 ctg ggt cga gtc ttt tct ctc aac ttt tgg aag gga cag tga 954 Leu Gly Arg Val Phe Ser Leu Asn Phe Trp Lys Gly Gln 305 310 315 <210> 292 <211> 317 <212> PRT <213> Homo sapiens <400> 292 Met Gln Pro Tyr Thr Lys Asn Trp Thr Gln Val Thr Glu Phe Val Met 1 5 10 15 Met Gly Phe Ala Gly Ile His Glu Ala His Leu Leu Phe Phe Ile Leu 20 25 30 Phe Leu Thr Met Tyr Leu Phe Thr Leu Val Glu Asn Leu Ala Ile Ile 35 40 45 Leu Val Val Gly Leu Asp His Arg Leu Arg Arg Pro Met Tyr Phe Phe 50 55 60 Leu Thr His Leu Ser Cys Leu Glu Ile Trp Tyr Thr Ser Val Thr Val 65 70 75 80 Pro Lys Met Leu Ala Gly Phe Ile Gly Val Asp Gly Gly Lys Asn Ile 85 90 95 Ser Tyr Ala Gly Cys Leu Ser Gln Leu Phe Ile Phe Thr Phe Leu Gly 100 105 110 Ala Thr Glu Cys Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val 115 120 125 Ala Ile Cys Met Pro Leu His Tyr Gly Ala Phe Val Ser Trp Gly Thr 130 135 140 Cys Ile Arg Leu Ala Ala Ala Cys Trp Leu Val Gly Phe Leu Thr Pro 145 150 155 160 Ile Leu Pro Ile Tyr Leu Leu Ser Gln Leu Thr Phe Cys Gly Pro Asn 165 170 175 Val Ile Asp His Phe Ser Cys Asp Ala Ser Pro Leu Leu Ala Leu Ser 180 185 190 Cys Ser Asp Val Thr Trp Lys Glu Thr Val Asp Phe Leu Val Ser Leu 195 200 205 Ala Val Leu Leu Ala Ser Ser Met Val Ile Ala Val Ser Tyr Gly Asn 210 215 220 Ile Val Trp Thr Leu Leu His Ile Arg Ser Ala Ala Glu Arg Trp Lys 225 230 235 240 Ala Phe Ser Thr Cys Ala Ala His Leu Thr Val Val Ser Leu Phe Tyr 245 250 255 Gly Thr Leu Phe Phe Met Tyr Val Gln Thr Lys Val Thr Ser Ser Ile 260 265 270 Asn Phe Asn Lys Val Val Ser Val Phe Tyr Ser Val Val Thr Pro Met 275 280 285 Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Gly Ala 290 295 300 Leu Gly Arg Val Phe Ser Leu Asn Phe Trp Lys Gly Gln 305 310 315 <210> 293 <211> 945 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(945) <400> 293 atg gcc aag aat aat ctc acc aga gta acc gaa ttc att ctc atg ggc 48 Met Ala Lys Asn Asn Leu Thr Arg Val Thr Glu Phe Ile Leu Met Gly 1 5 10 15 ttt atg gac cac ccc aaa ttg gag att ccc ctc ttt ctg gtg ttt ctg 96 Phe Met Asp His Pro Lys Leu Glu Ile Pro Leu Phe Leu Val Phe Leu 20 25 30 agt ttc tac cta gtc acc ctt ctt ggg aat gtg ggg atg att atg tta 144 Ser Phe Tyr Leu Val Thr Leu Leu Gly Asn Val Gly Met Ile Met Leu 35 40 45 atc caa gta gat gtc aaa ctc tac acc cca atg tac ttc ttc ctg agc 192 Ile Gln Val Asp Val Lys Leu Tyr Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 cac ctc tcc ctg ctg gat gcc tgt tac acc tca gtc atc acc cct cag 240 His Leu Ser Leu Leu Asp Ala Cys Tyr Thr Ser Val Ile Thr Pro Gln 65 70 75 80 atc cta gcc aca ttg gcc aca ggc aaa acg gtc atc tcc tac ggc cac 288 Ile Leu Ala Thr Leu Ala Thr Gly Lys Thr Val Ile Ser Tyr Gly His 85 90 95 tgt gct gcc cag ttc ttt tta ttc acc atc tgt gca ggc aca gag tgc 336 Cys Ala Ala Gln Phe Phe Leu Phe Thr Ile Cys Ala Gly Thr Glu Cys 100 105 110 ttt ctg ctg gca gtg atg gcc tat gat cgc tat gct gcc att cgc aac 384 Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Ala Ala Ile Arg Asn 115 120 125 cca ctg ctc tat acc gtg gcc atg aat ccc agg ctc tgc tgg agc ctg 432 Pro Leu Leu Tyr Thr Val Ala Met Asn Pro Arg Leu Cys Trp Ser Leu 130 135 140 gtg gta gga gcc tat gtc tgt ggg gtg tca gga gcc atc ctg cgt acc 480 Val Val Gly Ala Tyr Val Cys Gly Val Ser Gly Ala Ile Leu Arg Thr 145 150 155 160 act tgc acc ttc acc ctc tcc ttc tgt aag gac aat caa ata aac ttc 528 Thr Cys Thr Phe Thr Leu Ser Phe Cys Lys Asp Asn Gln Ile Asn Phe 165 170 175 ttc ttc tgt gac ctc cca ccc ctg ctg aag ctt gcc tgc agt gac aca 576 Phe Phe Cys Asp Leu Pro Pro Leu Leu Lys Leu Ala Cys Ser Asp Thr 180 185 190 gca aac atc gag att gtc atc atc ttc ttt ggc aat ttt gtg att ttg 624 Ala Asn Ile Glu Ile Val Ile Ile Phe Phe Gly Asn Phe Val Ile Leu 195 200 205 g cc aat gcc tcc gtc atc ctg att tcc tat ctg ctc atc atc aag acc 672 Ala Asn Ala Ser Val Ile Leu Ile Ser Tyr Leu Leu Ile Ile Lys Thr 210 215 220 att ttg aaa gtg aag tct tca ggt ggc agg gcc aag act ttc tcc aca 720 Ile Leu Lys Val Lys Ser Ser Gly Gly Arg Ala Lys Thr Phe Ser Thr 225 230 235 240 tgt gcc tct cac atc act gct gtg gcc ctt ttc ttt gga gcc ctt atc 768 Cys Ala Ser His Ile Thr Ala Val Ala Leu Phe Phe Gly Ala Leu Ile 245 250 255 ttc atg tat ctg caa agt ggc tca ggc aaa tct ctg gag gaa gac aaa 816 Phe Met Tyr Leu Gln Ser Gly Ser Gly Lys Ser Leu Glu Glu Asp Lys 260 265 270 gtc gtg tct gtc ttc tat aca gtg gtc atc ccc atg ctg aac cct ctg 864 Val Val Ser Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro Leu 275 280 285 atc tac agc tta aga aac aaa gat gta aaa gac gcc ttc aga aag gtc 912 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Asp Ala Phe Arg Lys Val 290 295 300 gct agg aga ctc cag gtg tcc ctg agc atg tag 945 Ala Arg Arg Leu Gln Val Ser Leu Ser Met 305 310 315 <210> 294 <211> 314 <212> PRT <213> Homo sapiens <400> 294 Met Ala Lys Asn Asn Leu Thr Arg Val Thr Glu Phe Ile Leu Met Gly 1 5 10 15 Phe Met Asp His Pro Lys Leu Glu Ile Pro Leu Phe Leu Val Phe Leu 20 25 30 Ser Phe Tyr Leu Val Thr Leu Leu Gly Asn Val Gly Met Ile Met Leu 35 40 45 Ile Gln Val Asp Val Lys Leu Tyr Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 His Leu Ser Leu Leu Asp Ala Cys Tyr Thr Ser Val Ile Thr Pro Gln 65 70 75 80 Ile Leu Ala Thr Leu Ala Thr Gly Lys Thr Val Ile Ser Tyr Gly His 85 90 95 Cys Ala Ala Gln Phe Phe Leu Phe Thr Ile Cys Ala Gly Thr Glu Cys 100 105 110 Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Ala Ala Ile Arg Asn 115 120 125 Pro Leu Leu Tyr Thr Val Ala Met Asn Pro Arg Leu Cys Trp Ser Leu 130 135 140 Val Val Gly Ala Tyr Val Cys Gly Val Ser Gly Ala Ile Leu Arg Thr 145 150 155 160 Thr Cys Thr Phe Thr Leu Ser Phe Cys Lys Asp Asn Gln Ile Asn Phe 165 170 175 Phe Phe Cys Asp Leu Pro Pro Leu Leu Lys Leu Ala Cys Ser Asp Thr 180 185 190 Ala Asn Ile Glu Ile Val Ile Ile Phe Phe Gly Asn Phe Val Ile Leu 195 200 205 Ala Asn Ala Ser Val Ile Leu Ile Ser Tyr Leu Leu Ile Ile Lys Thr 210 215 220 Ile Leu Lys Val Lys Ser Ser Gly Gly Arg Ala Lys Thr Phe Ser Thr 225 230 235 240 Cys Ala Ser His Ile Thr Ala Val Ala Leu Phe Phe Gly Ala Leu Ile 245 250 255 Phe Met Tyr Leu Gln Ser Gly Ser Gly Lys Ser Leu Glu Glu Asp Lys 260 265 270 Val Val Ser Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Asp Ala Phe Arg Lys Val 290 295 300 Ala Arg Arg Leu Gln Val Ser Leu Ser Met 305 310 <210> 295 <211> 702 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(702) <400> 295 atg gcc aaa aga aat ctc agc act gtg aca gag ttc att ctt gta gtc 48 Met Ala Lys Arg Asn Leu Ser Thr Val Thr Glu Phe Ile Leu Val Val 1 5 10 15 ttc aca gat cac cct gaa ctg gca gtt cca ctc ttc cta gtg ttt ctc 96 Phe Thr Asp His Pro Glu Leu Ala Val Pro Leu Phe Leu Val Phe Leu 20 25 30 agt ttc tat ctt gtc act ttt ctg ggg aat ggg ggg atg atc att cta 144 Ser Phe Tyr Leu Val Thr Phe Leu Gly Asn Gly Gly Met Ile Ile Leu 35 40 45 atc caa gtg gat gcc caa ctc cac acc ccc gtg tac ttc ttc ctg agc 192 Ile Gln Val Asp Ala Gln Leu His Thr Pro Val Tyr Phe Phe Leu Ser 50 55 60 cac ctt gct ttc ctg gat gcc tgc tgt gcc tca gta atc acc cct cag 240 His Leu Ala Phe Leu Asp Ala Cys Cys Ala Ser Val Ile Thr Pro Gln 65 70 75 80 att ctg gcc aca ctg gcc aca gac aag aca gtt atc tcc tat ggc tgc 288 Ile Leu Ala Thr Leu Ala Thr Asp Lys Thr Val Ile Ser Tyr Gly Cys 85 90 95 cgt gct gtg cag ttc tct ttc ttc acc ata tgt gca ggc aca gag tgt 336 Arg Ala Val Gln Phe Ser Phe Phe Thr Ile Cys Ala Gly Thr Glu Cys 100 105 110 tac ctg ctg tca gtg atg gcc tat gac cgc ttt gtt gcc att agc aat 384 Tyr Leu Leu Ser Val Met Ala Tyr Asp Arg Phe Val Ala Ile Ser Asn 115 120 125 cca ctg cac tgt aac atg acc atg act cca ggt acc tgc agg gtc ttt 432 Pro Leu His Cys Asn Met Thr Met Thr Pro Gly Thr Cys Arg Val Phe 130 135 140 ttg gcc agt gcc ttc atc tgt ggg gtg tca ggg gcc att ctg cat acc 480 Leu Ala Ser Ala Phe Ile Cys Gly Val Ser Gly Ala Ile Leu His Thr 145 150 155 160 acg tgc acc ttc acc ctc tcc ttc tgt tgt gac aat cag atc aac ttc 528 Thr Cys Thr Phe Thr Leu Ser Phe Cys Cys Asp Asn Gln Ile Asn Phe 165 170 175 ttc ttc tgt gac ctc cca ccc ctg ctg aag ctc gcc tgc agc agc atg 576 Phe Phe Cys Asp Leu Pro Pro Leu Leu Lys Leu Ala Cys Ser Ser Met 180 185 190 aca caa act gag att gtc att ctc ctt tgt gca aaa tgc atg ttc cta 624 Thr Gln Thr Glu Ile Val Ile Leu Leu Cys Ala Lys Cys Met Phe Leu 195 200 205 gcc aat gtc atg gtt atc ctg atc tgc tac atg ctc att atc aga gcc 672 Ala Asn Val Met Val Ile Leu Ile Cys Tyr Met Leu Ile Ile Arg Ala 210 215 220 att ttg agg gtg aag tcg gca ggt ggg taa 702 Ile Leu Arg Val Lys Ser Ala Gly Gly 225 230 <210> 296 <211> 233 <212> PRT <213> Homo sapiens <400> 296 Met Ala Lys Arg Asn Leu Ser Thr Val Thr Glu Phe Ile Leu Val Val 1 5 10 15 Phe Thr Asp His Pro Glu Leu Ala Val Pro Leu Phe Leu Val Phe Leu 20 25 30 Ser Phe Tyr Leu Val Thr Phe Leu Gly Asn Gly Gly Met Ile Ile Leu 35 40 45 Ile Gln Val Asp Ala Gln Leu His Thr Pro Val Tyr Phe Phe Leu Ser 50 55 60 His Leu Ala Phe Leu Asp Ala Cys Cys Ala Ser Val Ile Thr Pro Gln 65 70 75 80 Ile Leu Ala Thr Leu Ala Thr Asp Lys Thr Val Ile Ser Tyr Gly Cys 85 90 95 Arg Ala Val Gln Phe Ser Phe Phe Thr Ile Cys Ala Gly Thr Glu Cys 100 105 110 Tyr Leu Leu Ser Val Met Ala Tyr Asp Arg Phe Val Ala Ile Ser Asn 115 120 125 Pro Leu His Cys Asn Met Thr Met Thr Pro Gly Thr Cys Arg Val Phe 130 135 140 Leu Ala Ser Ala Phe Ile Cys Gly Val Ser Gly Ala Ile Leu His Thr 145 150 155 160 Thr Cys Thr Phe Thr Leu Ser Phe Cys Cys Asp Asn Gln Ile Asn Phe 165 170 175 Phe Phe Cys Asp Leu Pro Pro Leu Leu Lys Leu Ala Cys Ser Ser Met 180 185 190 Thr Gln Thr Glu Ile Val Ile Leu Leu Cys Ala Lys Cys Met Phe Leu 195 200 205 Ala Asn Val Met Val Ile Leu Ile Cys Tyr Met Leu Ile Ile Arg Ala 210 215 220 Ile Leu Arg Val Lys Ser Ala Gly Gly 225 230 <2 10> 297 <211> 1014 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1014) <400> 297 atg gaa gga ata aat aaa act gca aag atg cag ttt ttc ttt cgt cca 48 Met Glu Gly Ile Asn Lys Thr Ala Lys Met Gln Phe Phe Phe Arg Pro 1 5 10 15 ttc tca cct gac cct gag gtc cag atg ctg att ttt gtg gtc ttc ctg 96 Phe Ser Pro Asp Pro Glu Val Gln Met Leu Ile Phe Val Val Phe Leu 20 25 30 atg atg tat ctg acc agc ctc ggt gga aat gct aca att gca gtc att 144 Met Met Tyr Leu Thr Ser Leu Gly Gly Asn Ala Thr Ile Ala Val Ile 35 40 45 gtt cag atc aat cat tcc ctc cac acc ccc atg tac ttt ttc ctg gct 192 Val Gln Ile Asn His Ser Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 aat ctg gca gtt cta gaa atc ttc tat aca tct tcc atc acc cca ttg 240 Asn Leu Ala Val Leu Glu Ile Phe Tyr Thr Ser Ser Ile Thr Pro Leu 65 70 75 80 gcc ttg gca aac ctc ctt tca atg ggc aaa act cct gtt tcc atc acg 288 Ala Leu Ala Asn Leu Leu Ser Met Gly Lys Thr Pro Val Ser Ile Thr 85 90 95 gga tgt ggc acc cag atg ttt ttc ttt gtc ttc ttg ggt ggg gct gat 336 Gly Cys Gly Thr Gln Met Phe Phe Phe Val Phe Leu Gly Gly Ala Asp 100 105 110 tgt gtc ctg ctg gta gtc atg gct tat gac cag ttt ata gcg atc tgt 384 Cys Val Leu Leu Val Val Met Ala Tyr Asp Gln Phe Ile Ala Ile Cys 115 120 125 cac cct ctg cga tac agg ctc atc atg agc tgg tcc ttg tgt gtg gag 432 His Pro Leu Arg Tyr Arg Leu Ile Met Ser Trp Ser Leu Cys Val Glu 130 135 140 ctg ctg gta ggc tcc ttg gtg ctg ggg ttc ctg ttg tca ctg cca ctc 480 Leu Leu Val Gly Ser Leu Val Leu Gly Phe Leu Leu Ser Leu Pro Leu 145 150 155 160 acc att tta atc ttc cat ctc cca ttc tgc cac aat gat gag atc tac 528 Thr Ile Leu Ile Phe His Leu Pro Phe Cys His Asn Asp Glu Ile Tyr 165 170 175 cac ttc tac tgt gac atg cct gca gtc atg cgc ctg gct tgt gca gac 576 His Phe Tyr Cys Asp Met Pro Ala Val Met Arg Leu Ala Cys Ala Asp 180 185 190 aca cgc gtt cac aag act gct ctg tat atc atc agc ttc atc gtc ctt 624 Thr Arg Val His Lys Thr Ala Leu Tyr Ile Ile Ser Phe Ile Val Leu 195 200 205 agc atc ccc ctc tca ttg atc tcc atc tcc tat gtc ttc atc gtg gta 672 Ser Ile Pro Leu Ser Leu Ile Ser Ile Ser Tyr Val Phe Ile Val Val 210 215 220 gcc att tta cgg atc cgg tca gca gaa ggg cgc cag caa gcc tac tct 720 Ala Ile Leu Arg Ile Arg Ser Ala Glu Gly Arg Gln Gln Ala Tyr Ser 225 230 235 240 acc tgc tct tct cac atc tta gtg gtc ctc ctg cag tat ggc tgc acc 768 Thr Cys Ser Ser His Ile Leu Val Val Leu Leu Gln Tyr Gly Cys Thr 245 250 255 a gc ttt ata tac ttg tcc ccc agt tcc agc tac tct cct gag atg ggc 816 Ser Phe Ile Tyr Leu Ser Pro Ser Ser Ser Tyr Ser Pro Glu Met Gly 260 265 270 cgg gtg gta tct gtg gcc tac aca ttt atc act ccc att tta aac ccc 864 Arg Val Val Ser Val Ala Tyr Thr Phe Ile Thr Pro Ile Leu Asn Pro 275 280 285 ttg atc tat agt ttg agg aac aag gaa ctg aaa gat gcn nnn nnn nnn 912 Leu Ile Tyr Ser Leu Arg Asn Lys Glu Leu Lys Asp Ala Xaa Xaa Xaa 290 295 300 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 960 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 305 310 315 320 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn cag cct 1008 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Pro 325 330 335 gag tga 1014 Glu <210> 298 <211> 337 <212> PRT <213> Homo sapiens <400> 298 Met Glu Gly Ile Asn Lys Thr Ala Lys Met Gln Phe Phe Phe Arg Pro 1 5 10 15 Phe Ser Pro Asp Pro Glu Val Gln Met Leu Ile Phe Val Val Phe Leu 20 25 30 Met Met Tyr Leu Thr Ser Leu Gly Gly Asn Ala Thr Ile Ala Val Ile 35 40 45 Val Gln Ile Asn His Ser Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ala Val Leu Glu Ile Phe Tyr Thr Ser Ser Ile Thr Pro Leu 65 70 75 80 Ala Leu Ala Asn Leu Leu Ser Met Gly Lys Thr Pro Val Ser Ile Thr 85 90 95 Gly Cys Gly Thr Gln Met Phe Phe Phe Val Phe Leu Gly Gly Ala Asp 100 105 110 Cys Val Leu Leu Val Val Met Ala Tyr Asp Gln Phe Ile Ala Ile Cys 115 120 125 His Pro Leu Arg Tyr Arg Leu Ile Met Ser Trp Ser Leu Cys Val Glu 130 135 140 Leu Leu Val Gly Ser Leu Val Leu Gly Phe Leu Leu Ser Leu Pro Leu 145 150 155 160 Thr Ile Leu Ile Phe His Leu Pro Phe Cys His Asn Asp Glu Ile Tyr 165 170 175 His Phe Tyr Cys Asp Met Pro Ala Val Met Arg Leu Ala Cys Ala Asp 180 185 190 Thr Arg Val His Lys Thr Ala Leu Tyr Ile Ile Ser Phe Ile Val Leu 195 200 205 Ser Ile Pro Leu Ser Leu Ile Ser Ile Ser Tyr Val Phe Ile Val Val 210 215 220 Ala Ile Leu Arg Ile Arg Ser Ala Glu Gly Arg Gln Gln Ala Tyr Ser 225 230 235 240 Thr Cys Ser Ser His Ile Leu Val Val Leu Leu Gln Tyr Gly Cys Thr 245 250 255 Ser Phe Ile Tyr Leu Ser Pro Ser Ser Ser Tyr Ser Pro Glu Met Gly 260 265 270 Arg Val Val Ser Val Ala Tyr Thr Phe Ile Thr Pro Ile Leu Asn Pro 275 280 285 Leu Ile Tyr Ser Leu Arg Asn Lys Glu Leu Lys Asp Ala Xaa Xaa Xaa 290 295 300 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 305 310 315 320 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Pro 325 330 335 Glu <210> 299 <211> 813 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(813) <400> 299 atg acc att gtc ttg ctt tca gct ctg gat tcc cgg ctg cac aca cca 48 Met Thr Ile Val Leu Leu Ser Ala Leu Asp Ser Arg Leu His Thr Pro 1 5 10 15 atg tat ttc ttt ttg gca aac ctc tca ttc ctg gac atg tgt ttc acc 96 Met Tyr Phe Phe Leu Ala Asn Leu Ser Phe Leu Asp Met Cys Phe Thr 20 25 30 aca ggt tcc atc cct cag atg ctc tac aac ctt tgg ggt cca gat aag 144 Thr Gly Ser Ile Pro Gln Met Leu Tyr Asn Leu Trp Gly Pro Asp Lys 35 40 45 acc atc agc tat gtg ggt tgt gcc atc cag ctg tac ttt gtc ctg gcc 192 Thr Ile Ser Tyr Val Gly Cys Ala Ile Gln Leu Tyr Phe Val Leu Ala 50 55 60 ctg gga ggg gtg gag tgt gtc ctc ctg gct gtc atg gca tat gac cgc 240 Leu Gly Gly Val Glu Cys Val Leu Leu Ala Val Met Ala Tyr Asp Arg 65 70 75 80 tat gct gca gtc tgc aaa ccc ctg cac tac acc atc atc atg cac cca 288 Tyr Ala Ala Val Cys Lys Pro Leu His Tyr Thr Ile Ile Met His Pro 85 90 95 cgt ctc tgt gga cag ctg gct tca gtg gca tgg ctg agt ggc ttt ggc 336 Arg Leu Cys Gly Gln Leu Ala Ser Val Ala Trp Leu Ser Gly Phe Gly 100 105 110 aat tct ctc ata atg gca ccc cag aca ttg atg cta ccc cgc tgt ggg 384 Asn Ser Leu Ile Met Ala Pro Gln Thr Leu Met Leu Pro Arg Cys Gly 115 120 125 cac aga cga gtt gac cac ttt ctc tgt gag atg cca gca cta att ggt 432 His Arg Arg Val Asp His Phe Leu Cys Glu Met Pro Ala Leu Ile Gly 130 135 140 atg gcc tgt gta gac acc atg atg ctt gag gca ctg gct ttt gcc ctg 480 Met Ala Cys Val Asp Thr Met Met Leu Glu Ala Leu Ala Phe Ala Leu 145 150 155 160 gca atc ttt atc atc ctg gca cca ctc atc ctc att ctc att tct tat 528 Ala Ile Phe Ile Ile Leu Ala Pro Leu Ile Leu Ile Leu Ile Ser Tyr 165 170 175 ggt tac gtt gga gga aca gtg ctt agg atc aag tca gct gct ggg cga 576 Gly Tyr Val Gly Gly Thr Val Leu Arg Ile Lys Ser Ala Ala Gly Arg 180 185 190 aag aaa gcc ttc aac act tgc agc tcg cat cta att gtt gtc tct ctc 624 Lys Lys Ala Phe Asn Thr Cys Ser Ser His Leu Ile Val Val Ser Leu 195 200 205 ttc tat ggt aca atc ata tac atg tac ctc cag cca gca aat act tat 672 Phe Tyr Gly Thr Ile Ile Tyr Met Tyr Leu Gln Pro Ala Asn Thr Tyr 210 215 220 tcc cag gac cag ggc aag ttt ctt acc ctt ttc tac aca att gtc act 720 Ser Gln Asp Gln Gly Lys Phe Leu Thr Leu Phe Tyr Thr Ile Val Thr 225 230 235 240 ccc agt gtt aac ccc ctg atc tat aca cta aga aac aaa gat gtt aaa 768 Pro Ser Val Asn Pro Leu Ile Tyr Thr Leu Arg Asn Lys Asp Val Lys 245 250 255 gag gcc atg aag aag gtg cta ggg aag ggg agt gca gaa ata tag 813 Glu Ala Met Lys Lys Val Leu Gly Lys Gly Ser Ala Glu Ile 260 265 270 <210> 300 <211> 270 <212> PRT <213> Homo sapiens <400> 300 Met Thr Ile Val Leu Leu Ser Ala Leu Asp Ser Arg Leu His Thr Pro 1 5 10 15 Met Tyr Phe Phe Leu Ala Asn Leu Ser Phe Leu Asp Met Cys Phe Thr 20 25 30 Thr Gly Ser Ile Pro Gln Met Leu Tyr Asn Leu Trp Gly Pro Asp Lys 35 40 45 Thr Ile Ser Tyr Val Gly Cys Ala Ile Gln Leu Tyr Phe Val Leu Ala 50 55 60 Leu Gly Gly Val Glu Cys Val Leu Leu Ala Val Met Ala Tyr Asp Arg 65 70 75 80 Tyr Ala Ala Val Cys Lys Pro Leu His Tyr Thr Ile Ile Met His Pro 85 90 95 Arg Leu Cys Gly Gln Leu Ala Ser Val Ala Trp Leu Ser Gly Phe Gly 100 105 110 Asn Ser Leu Ile Met Ala Pro Gln Thr Leu Met Leu Pro Arg Cys Gly 115 120 125 His Arg Arg Val Asp His Phe Leu Cys Glu Met Pro Ala Leu Ile Gly 130 135 140 Met Ala Cys Val Asp Thr Met Met Leu Glu Ala Leu Ala Phe Ala Leu 145 150 155 160 Ala Ile Phe Ile Ile Leu Ala Pro Leu Ile Leu Ile Leu Ile Ser Tyr 165 170 175 Gly Tyr Val Gly Gly Thr Val Leu Arg Ile Lys Ser Ala Ala Gly Arg 180 185 190 Lys Lys Ala Phe Asn Thr Cys Ser Ser His Leu Ile Val Val Ser Leu 195 200 205 Phe Tyr Gly Thr Ile Ile Tyr Met Tyr Leu Gln Pro Ala Asn Thr Tyr 210 215 220 Ser Gln Asp Gln Gly Lys Phe Leu Thr Leu Phe Tyr Thr Ile Val Thr 225 230 235 240 Pro Ser Val Asn Pro Leu Ile Tyr Thr Leu Arg Asn Lys Asp Val Lys 245 250 255 Glu Ala Met Lys Lys Val Leu Gly Lys Gly Ser Ala Glu Ile 260 265 270 <210> 301 <211> 942 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(942) <400> 301 atg aat tgg gta aat gac agc atc ata cag gag ttt att ctg ctg ggt 48 Met Asn Trp Val Asn Asp Ser Ile Ile Gln Glu Phe Ile Leu Leu Gly 1 5 10 15 ttc tca gat cga cct tgg ctg gag ttt cca ctc ctt gtg gtc ttc ttg 96 Phe Ser Asp Arg Pro Trp Leu Glu Phe Pro Leu Leu Val Val Phe Leu 20 25 30 att tct tac act gtg acc atc ttt ggc aat ctg acc att att cta gtg 144 Ile Ser Tyr Thr Val Thr Ile Phe Gly Asn Leu Thr Ile Ile Leu Val 35 40 45 tca cgc ctg gac acc aaa ctt cat acc ccc atg tat ttt ttt ctt acc 192 Ser Arg Leu Asp Thr Lys Leu His Thr Pro Met Tyr Phe Phe Leu Thr 50 55 60 aat cta tca ctc ctg gat ctt tgt tac acc aca tgt aca gtc cca caa 240 Asn Leu Ser Leu Leu Asp Leu Cys Tyr Thr Thr Cys Thr Val Pro Gln 65 70 75 80 atg cta gta aat tta tgc agc atc agg aaa gta atc agt tat cgt ggc 288 Met Leu Val Asn Leu Cys Ser Ile Arg Lys Val Ile Ser Tyr Arg Gly 85 90 95 tgt gta gcc cag ctt ttc ata ttt ctg gcc ttg ggg gct act gaa tat 336 Cys Val Ala Gln Leu Phe Ile Phe Leu Ala Leu Gly Ala Thr Glu Tyr 100 105 110 ctt ctc ctg gcc gtc atg tcc ttt gat agg ttt gta gct att tgt cgg 384 Leu Leu Leu Ala Val Met Ser Phe Asp Arg Phe Val Ala Ile Cys Arg 115 120 125 cct ctc cat tac tca gtt atc atg cac cag aga ctc tgc ctc cag ttg 432 Pro Leu His Tyr Ser Val Ile Met His Gln Arg Leu Cys Leu Gln Leu 130 135 140 gca gct gca tcc tgg gtt act ggt ttt agt aac tca gtg tgg ttg tct 480 Ala Ala Ala Ser Trp Val Thr Gly Phe Ser Asn Ser Val Trp Leu Ser 145 150 155 160 acc ctg act ctc cag ctg cca ctc tgt gac ccc tat gtg ata gat cac 528 Thr Leu Thr Leu Gln Leu Pro Leu Cys Asp Pro Tyr Val Ile Asp His 165 170 175 ttt ctc tgt gaa gtc cct gca ctg ctc aag tta tct tgt gtt gag aca 576 Phe Leu Cys Glu Val Pro Ala Leu Leu Lys Leu Ser Cys Val Glu Thr 180 185 190 aca gca aat gag gct gaa cta ttc ctt gtc agt gag ctc ttc cat cta 624 Thr Ala Asn Glu Ala Glu Leu Phe Leu Val Ser Glu Leu Phe His Leu 195 200 205 ata ccc ctg aca ctc atc ctt ata tca tat gct ttt att gtc cga gca 672 Ile Pro Leu Thr Leu Ile Leu Ile Ser Tyr Ala Phe Ile Val Arg Ala 210 215 220 gta ttg agg ata cag tct gct gaa ggt cga caa aaa gca ttt ggg aca 720 Val Leu Arg Ile Gln Ser Ala Glu Gly Arg Gln Lys Ala Phe Gly Thr 225 230 235 240 tgt ggt tcc cat cta att gtg gtg tct ctt ttt tat agt aca gcc gtc 768 Cys Gly Ser His Leu Ile Val Val Ser Leu Phe Tyr Ser Thr Ala Val 245 250 255 tct gtg tac ctg caa cca cct tcg ccc agc tcc aag gac caa gga aag 816 Ser Val Tyr Leu Gln Pro Pro Ser Pro Ser Ser Lys Asp Gln Gly Lys 260 265 270 atg gtt tct ctc ttc tat gga atc att gca ccc atg ctg aat ccc ctt 864 Met Val Ser Leu Phe Tyr Gly Ile Ile Ala Pro Met Leu Asn Pro Leu 275 280 285 ata tat aca ctt agg aac aag gag gta aag gaa ggc ttt aaa agg ttg 912 Ile Tyr Thr Leu Arg Asn Lys Glu Val Lys Glu Gly Phe Lys Arg Leu 290 295 300 gtt gca aga gtc ttc tta atc aag aaa taa 942 Val Ala Arg Val Phe Leu Ile Lys Lys 305 310 <210> 302 <211> 313 <212> PRT <213> Homo sapiens <400> 302 Met Asn Trp Val Asn Asp Ser Ile Ile Gln Glu Phe Ile Leu Leu Gly 1 5 10 15 Phe Ser Asp Arg Pro Trp Leu Glu Phe Pro Leu Leu Val Val Phe Leu 20 25 30 Ile Ser Tyr Thr Val Thr Ile Phe Gly Asn Leu Thr Ile Ile Leu Val 35 40 45 Ser Arg Leu Asp Thr Lys Leu His Thr Pro Met Tyr Phe Phe Leu Thr 50 55 60 Asn Leu Ser Leu Leu Asp Leu Cys Tyr Thr Thr Cys Thr Val Pro Gln 65 70 75 80 Met Leu Val Asn Leu Cys Ser Ile Arg Lys Val Ile Ser Tyr Arg Gly 85 90 95 Cys Val Ala Gln Leu Phe Ile Phe Leu Ala Leu Gly Ala Thr Glu Tyr 100 105 110 Leu Leu Leu Ala Val Met Ser Phe Asp Arg Phe Val Ala Ile Cys Arg 115 120 125 Pro Leu His Tyr Ser Val Ile Met His Gln Arg Leu Cys Leu Gln Leu 130 135 140 Ala Ala Ala Ser Trp Val Thr Gly Phe Ser Asn Ser Val Trp Leu Ser 145 150 155 160 Thr Leu Thr Leu Gln Leu Pro Leu Cys Asp Pro Tyr Val Ile Asp His 165 170 175 Phe Leu Cys Glu Val Pro Ala Leu Leu Lys Leu Ser Cys Val Glu Thr 180 185 190 Thr Ala Asn Glu Ala Glu Leu Phe Leu Val Ser Glu Leu Phe His Leu 195 200 205 Ile Pro Leu Thr Leu Ile Leu Ile Ser Tyr Ala Phe Ile Val Arg Ala 210 215 220 Val Leu Arg Ile Gln Ser Ala Glu Gly Arg Gln Lys Ala Phe Gly Thr 225 230 235 240 Cys Gly Ser His Leu Ile Val Val Ser Leu Phe Tyr Ser Thr Ala Val 245 250 255 Ser Val Tyr Leu Gln Pro Pro Ser Pro Ser Ser Lys Asp Gln Gly Lys 260 265 270 Met Val Ser Leu Phe Tyr Gly Ile Ile Ala Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Thr Leu Arg Asn Lys Glu Val Lys Glu Gly Phe Lys Arg Leu 290 295 300 Val Ala Arg Val Phe Leu Ile Lys Lys 305 310 <21 0> 303 <211> 813 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(813) <400> 303 atg ggg aat ctt ggt cta att gtt ctc atc tgg aaa gac cct cac ctt 48 Met Gly Asn Leu Gly Leu Ile Val Leu Ile Trp Lys Asp Pro His Leu 1 5 10 15 cat atc cca atg tat tta ttc cgt ggg agt ttg gcc ttt gtg gat gct 96 His Ile Pro Met Tyr Leu Phe Arg Gly Ser Leu Ala Phe Val Asp Ala 20 25 30 tgg tta tca tcc aca gtg act cca aag atg ctg atc aac ttc tta gct 144 Trp Leu Ser Ser Thr Val Thr Pro Lys Met Leu Ile Asn Phe Leu Ala 35 40 45 aag agt aag atg ata tct ctc tct gaa tgc atg gta caa ttt ttt tcc 192 Lys Ser Lys Met Ile Ser Leu Ser Glu Cys Met Val Gln Phe Phe Ser 50 55 60 ttt gta atc agt gta acc aca gaa tgt ttt atc tcg gca tca atg gca 240 Phe Val Ile Ser Val Thr Thr Glu Cys Phe Ile Ser Ala Ser Met Ala 65 70 75 80 tat gat cgc tat gta gcc att tgc aaa gct tta ctt tat cca gtc att 288 Tyr Asp Arg Tyr Val Ala Ile Cys Lys Ala Leu Leu Tyr Pro Val Ile 85 90 95 atg acc aac gga cta tgc atc cag cta tta gtc ttg tca ttt ata ggt 336 Met Thr Asn Gly Leu Cys Ile Gln Leu Leu Val Leu Ser Phe Ile Gly 100 105 110 ggc ctt ctt cat gct tta atc cat gaa att ttt tta ttc aga tta acc 384 Gly Leu Leu His Ala Leu Ile His Glu Ile Phe Leu Phe Arg Leu Thr 115 120 125 ttc tgt aat tcc aac ata ata caa cac ttt tac tgt gac att atc cca 432 Phe Cys Asn Ser Asn Ile Ile Gln His Phe Tyr Cys Asp Ile Ile Pro 130 135 140 ttg tta aag att tcc tgt act gat tct ttt att aac ttt cta atg gtt 480 Leu Leu Lys Ile Ser Cys Thr Asp Ser Phe Ile Asn Phe Leu Met Val 1 45 150 155 160 ttt att ttc gca gat tca att caa gtt ttt acc att gga act att ctt 528 Phe Ile Phe Ala Asp Ser Ile Gln Val Phe Thr Ile Gly Thr Ile Leu 165 170 175 ata tct tat aca ctt gtc ctc ctt ata atc tta aaa aat aag tct gtc 576 Ile Ser Tyr Thr Leu Val Leu Leu Ile Ile Leu Lys Asn Lys Ser Val 180 185 190 aaa ggg ata caa aaa gct gtc tcc acc tgt gga gct cat ctc tta tct 624 Lys Gly Ile Gln Lys Ala Val Ser Thr Cys Gly Ala His Leu Leu Ser 195 200 205 gta tct tta tac tat ggg ccc ctt gtc ttc atg tat gtg ggc tct gca 672 Val Ser Leu Tyr Tyr Gly Pro Leu Val Phe Met Tyr Val Gly Ser Ala 210 215 220 tcc ccg caa gca gat gac caa gat atg atg gag tct cta ttt tac act 720 Ser Pro Gln Ala Asp Asp Gln Asp Met Met Glu Ser Leu Phe Tyr Thr 225 230 235 240 gtc atc gtt cct tta tta aat tcc atg atc tac agc ctg aga aac aag 768 Val Ile Val Pro Leu Leu Asn Ser Met Ile Tyr Ser Leu Arg Asn Lys 245 250 255 caa gta ata gct tca ttc aca aaa atg ttc aaa aga aat gtt tag 813 Gln Val Ile Ala Ser Phe Thr Lys Met Phe Lys Arg Asn Val 260 265 270 <210> 304 <211> 270 <212> PRT <213> Homo sapiens <400> 304 Met Gly Asn Leu Gly Leu Ile Val Leu Ile Trp Lys Asp Pro His Leu 1 5 10 15 His Ile Pro Met Tyr Leu Phe Arg Gly Ser Leu Ala Phe Val Asp Ala 20 25 30 Trp Leu Ser Ser Thr Val Thr Pro Lys Met Leu Ile Asn Phe Leu Ala 35 40 45 Lys Ser Lys Met Ile Ser Leu Ser Glu Cys Met Val Gln Phe Phe Ser 50 55 60 Phe Val Ile Ser Val Thr Thr Glu Cys Phe Ile Ser Ala Ser Met Ala 65 70 75 80 Tyr Asp Arg Tyr Val Ala Ile Cys Lys Ala Leu Leu Tyr Pro Val Ile 85 90 95 Met Thr Asn Gly Leu Cys Ile Gln Leu Leu Val Leu Ser Phe Ile Gly 100 105 110 Gly Leu Leu His Ala Leu Ile His Glu Ile Phe Leu Phe Arg Leu Thr 115 120 125 Phe Cys Asn Ser Asn Ile Ile Gln His Phe Tyr Cys Asp Ile Ile Pro 130 135 140 Leu Leu Lys Ile Ser Cys Thr Asp Ser Phe Ile Asn Phe Leu Met Val 145 150 155 160 Phe Ile Phe Ala Asp Ser Ile Gln Val Phe Thr Ile Gly Thr Ile Leu 165 170 175 Ile Ser Tyr Thr Leu Val Leu Leu Ile Ile Leu Lys Asn Lys Ser Val 180 185 190 Lys Gly Ile Gln Lys Ala Val Ser Thr Cys Gly Ala His Leu Leu Ser 195 200 205 Val Ser Leu Tyr Tyr Gly Pro Leu Val Phe Met Tyr Val Gly Ser Ala 210 215 220 Ser Pro Gln Ala Asp Asp Gln Asp Met Met Glu Ser Leu Phe Tyr Thr 225 230 235 240 Val Ile Val Pro Leu Leu Asn Ser Met Ile Tyr Ser Leu Arg Asn Lys 245 250 255 Gln Val Ile Ala Ser Phe Thr Lys Met Phe Lys Arg Asn Val 260 265 270 <210> 305 <211> 945 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(945) <400> 305 atg tcg aat gag gac atg gaa cag gat aat aca aca ttg ctg aca gag 48 Met Ser Asn Glu Asp Met Glu Gln Asp Asn Thr Thr Leu Leu Thr Glu 1 5 10 15 ttt gtt ctc aca gga ctt aca tat cag cca gag tgg aaa atg ccc ctg 96 Phe Val Leu Thr Gly Leu Thr Tyr Gln Pro Glu Trp Lys Met Pro Leu 20 25 30 ttc ttg gtg ttc ttg gtg atc tat ctc atc act att gtg tgg aac ctt 144 Phe Leu Val Phe Leu Val Ile Tyr Leu Ile Thr Ile Val Trp Asn Leu 35 40 45 ggt ctg att gct ctt atc tgg aat gac cca caa ctt cac atc ccc atg 192 Gly Leu Ile Ala Leu Ile Trp Asn Asp Pro Gln Leu His Ile Pro Met 50 55 60 tac ttt ttt ctt ggg agt tta gcc ttt gtt gat gct tgg ata tct tcc 240 Tyr Phe Phe Leu Gly Ser Leu Ala Phe Val Asp Ala Trp Ile Ser Ser 65 70 75 80 aca gta act ccc aaa atg ttg gtt aat ttc ttg gcc aaa aac agg atg 288 Thr Val Thr Pro Lys Met Leu Val Asn Phe Leu Ala Lys Asn Arg Met 85 90 95 ata tct ctg tct gaa tgc atg att caa ttt ttt tcc ttt gca ttt ggt 336 Ile Ser Leu Ser Glu Cys Met Ile Gln Phe Phe Ser Phe Ala Phe Gly 100 105 110 gga act aca gaa tgt ttt ctc ttg gca aca atg gca tat gat cgc tat 384 Gly Thr Thr Glu Cys Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr 115 120 125 gta gcc ata tgc aaa cct tta cta tat cca gtg att atg aac aat tca 432 Val Ala Ile Cys Lys Pro Leu Leu Tyr Pro Val Ile Met Asn Asn Ser 130 135 140 cta tgc ata cgg ctg tta gcc ttc tca ttt tta ggt ggc ttc ctc cat 480 Leu Cys Ile Arg Leu Leu Ala Phe Ser Phe Leu Gly Gly Phe Leu His 145 150 155 160 gcc tta att cat gaa gtc ctt ata ttc aga tta acc ttc tgc aat tct 528 Ala Leu Ile His Glu Val Leu Ile Phe Arg Leu Thr Phe Cys Asn Ser 165 170 175 aac ata ata cat cat ttt tac tgt gat att ata cca ctg ttt atg att 576 Asn Ile Ile His His Phe Tyr Cys Asp Ile Ile Pro Leu Phe Met Ile 180 185 190 tcc tgt act gac cct tct att aat ttt cta atg gtt ttt att ttg tct 624 Ser Cys Thr Asp Pro Ser Ile Asn Phe Leu Met Val Phe Ile Leu Ser 195 200 205 ggc tca att cag gta ttc acc att gtg aca gtt ctt aat tct tac aca 672 Gly Ser Ile Gln Val Phe Thr Ile Val Thr Val Leu Asn Ser Tyr Thr 210 215 220 ttt gct ctt ttc aca atc cta aaa aag aag tct gtt aga ggc gta agg 720 Phe Ala Leu Phe Thr Ile Leu Lys Lys Lys Ser Val Arg Gly Val Arg 225 230 235 240 a aa gcc ttt tcc acc tgt gga gcc cat ctc tta tct gtc tct tta tat 768 Lys Ala Phe Ser Thr Cys Gly Ala His Leu Leu Ser Val Ser Leu Tyr 245 250 255 tat ggc cca ctt atc ttc atg tat ttg cgc cct gca tct cca caa gca 816 Tyr Gly Pro Leu Ile Phe Met Tyr Leu Arg Pro Ala Ser Pro Gln Ala 260 265 270 gat gac caa gat atg ata gac tct gtc ttt tat aca atc ata att cct 864 Asp Asp Gln Asp Met Ile Asp Ser Val Phe Tyr Thr Ile Ile Ile Pro 275 280 285 ttg cta aat ccc att atc tac agt ctg aga aat aaa caa gta ata gat 912 Leu Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Gln Val Ile Asp 290 295 300 tca ttc aca aaa atg gta aaa aga aat gtt tag 945 Ser Phe Thr Lys Met Val Lys Arg Asn Val 305 310 315 <210> 306 <211> 314 <212> PRT <213> Homo sapiens <400> 306 Met Ser Asn Glu Asp Met Glu Gln Asp Asn Thr Thr Leu Leu Thr Glu 1 5 10 15 Phe Val Leu Thr Gly Leu Thr Tyr Gln Pro Glu Trp Lys Met Pro Leu 20 25 30 Phe Leu Val Phe Leu Val Ile Tyr Leu Ile Thr Ile Val Trp Asn Leu 35 40 45 Gly Leu Ile Ala Leu Ile Trp Asn Asp Pro Gln Leu His Ile Pro Met 50 55 60 Tyr Phe Phe Leu Gly Ser Leu Ala Phe Val Asp Ala Trp Ile Ser Ser 65 70 75 80 Thr Val Thr Pro Lys Met Leu Val Asn Phe Leu Ala Lys Asn Arg Met 85 90 95 Ile Ser Leu Ser Glu Cys Met Ile Gln Phe Phe Ser Phe Ala Phe Gly 100 105 110 Gly Thr Thr Glu Cys Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr 115 120 125 Val Ala Ile Cys Lys Pro Leu Leu Tyr Pro Val Ile Met Asn Asn Ser 130 135 140 Leu Cys Ile Arg Leu Leu Ala Phe Ser Phe Leu Gly Gly Phe Leu His 145 150 155 160 Ala Leu Ile His Glu Val Leu Ile Phe Arg Leu Thr Phe Cys Asn Ser 165 170 175 Asn Ile Ile His His Phe Tyr Cys Asp Ile Ile Pro Leu Phe Met Ile 180 185 190 Ser Cys Thr Asp Pro Ser Ile Asn Phe Leu Met Val Phe Ile Leu Ser 195 200 205 Gly Ser Ile Gln Val Phe Thr Ile Val Thr Val Leu Asn Ser Tyr Thr 210 215 220 Phe Ala Leu Phe Thr Ile Leu Lys Lys Lys Ser Val Arg Gly Val Arg 225 230 235 240 Lys Ala Phe Ser Thr Cys Gly Ala His Leu Leu Ser Val Ser Leu Tyr 245 250 255 Tyr Gly Pro Leu Ile Phe Met Tyr Leu Arg Pro Ala Ser Pro Gln Ala 260 265 270 Asp Asp Gln Asp Met Ile Asp Ser Val Phe Tyr Thr Ile Ile Ile Pro 275 280 285 Leu Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Gln Val Ile Asp 290 295 300 Ser Phe Thr Lys Met Val Lys Arg Asn Val 305 310 <210> 307 <211> 978 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(978) <400> 307 atg ttc ctt tac ctt tgc ttc att ttt cag agg aca tgc agt gag gag 48 Met Phe Leu Tyr Leu Cys Phe Ile Phe Gln Arg Thr Cys Ser Glu Glu 1 5 10 15 atg gaa gag gaa aat gca aca ttg ctg aca gag ttt gtt ctc aca gga 96 Met Glu Glu Glu Asn Ala Thr Leu Leu Thr Glu Phe Val Leu Thr Gly 20 25 30 ttt tta cat caa cct gac tgt aaa ata ccg ctc ttc ctg gca ttc ttg 144 Phe Leu His Gln Pro Asp Cys Lys Ile Pro Leu Phe Leu Ala Phe Leu 35 40 45 gta ata tat ctc atc acc atc atg ggg aat ctt ggt cta att gtt ctc 192 Val Ile Tyr Leu Ile Thr Ile Met Gly Asn Leu Gly Leu Ile Val Leu 50 55 60 atc tgg aaa gac cct cac ctt cat atc cca atg tac tta ttc ctt ggg 240 Ile Trp Lys Asp Pro His Leu His Ile Pro Met Tyr Leu Phe Leu Gly 65 70 75 80 agt tta gcc ttt gtg gat gct tcg tta tca tcc aca gtg act ccg aag 288 Ser Leu Ala Phe Val Asp Ala Ser Leu Ser Ser Thr Val Thr Pro Lys 85 90 95 atg ctg atc aac ttc tta gct aag agt aag atg ata tct ctc tct gaa 336 Met Leu Ile Asn Phe Leu Ala Lys Ser Lys Met Ile Ser Leu Ser Glu 100 105 110 tgc atg gta caa ttt ttt tcc ctt gta acc act gta acc aca gaa tgt 384 Cys Met Val Gln Phe Phe Ser Leu Val Thr Thr Val Thr Thr Glu Cys 115 120 125 ttt ctc ttg gca aca atg gca tat gat cgc tat gta gcc att tgc aaa 432 Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys 130 135 140 gct tta ctt tat cca gtc att atg acc aat gaa cta tgc att cag cta 480 Ala Leu Leu Tyr Pro Val Ile Met Thr Asn Glu Leu Cys Ile Gln Leu 145 150 155 160 tta gtc ttg tca ttt ata ggt ggc ctt ctt cat gct tta atc cat gaa 528 Leu Val Leu Ser Phe Ile Gly Gly Leu Leu His Ala Leu Ile His Glu 165 170 175 gct ttt tca ttc aga tta acc ttc tgt aat tcc aac ata ata caa cac 576 Ala Phe Ser Phe Arg Leu Thr Phe Cys Asn Ser Asn Ile Ile Gln His 180 185 190 ttt tac tgt gac att atc cca ttg tta aag att tcc tgt act gat tcc 624 Phe Tyr Cys Asp Ile Ile Pro Leu Leu Lys Ile Ser Cys Thr Asp Ser 195 200 205 tct att aac ttt cta atg gtt ttt att ttc gca ggt tct gtt caa gtt 672 Ser Ile Asn Phe Leu Met Val Phe Ile Phe Ala Gly Ser Val Gln Val 210 215 220 ttt acc att gga act att ctt ata tct tat aca att atc ctc ttt aca 720 Phe Thr Ile Gly Thr Ile Leu Ile Ser Tyr Thr Ile Ile Leu Phe Thr 225 230 235 240 atc tta gaa aag aag tct atc aaa ggg ata cga aaa gct gtc tcc acc 768 Ile Leu Glu Lys Lys Ser Ile Lys Gly Ile Arg Lys Ala Val Ser Thr 245 250 255 tgt ggg gct cat ctc tta tct gta tct tta tac tat ggc ccc ctc acc 816 Cys Gly Ala His Leu Leu Ser Val Ser Leu Tyr Tyr Gly Pro Leu Thr 260 265 270 ttc aaa tat ctg ggc tct gca tct ccg caa gca gat gac caa gat atg 864 Phe Lys Tyr Leu Gly Ser Ala Ser Pro Gln Ala Asp Asp Gln Asp Met 275 280 285 atg gag tct cta ttt tac act gtc ata gtt cct tta tta aat ccc atg 912 Met Glu Ser Leu Phe Tyr Thr Val Ile Val Pro Leu Leu Asn Pro Met 290 295 300 atc tac agc ctg aga aac aag caa gta ata gct tca ttc aca aaa atg 960 Ile Tyr Ser Leu Arg Asn Lys Gln Val Ile Ala Ser Phe Thr Lys Met 305 310 315 320 ttc aaa agc aat gtt tag 978 Phe Lys Ser Asn Val 325 <210> 308 <211> 325 <212> PRT <213> Homo sapiens <400> 308 Met Phe Leu Tyr Leu Cys Phe Ile Phe Gln Arg Thr Cys Ser Glu Glu 1 5 10 15 Met Glu Glu Glu Asn Ala Thr Leu Leu Thr Glu Phe Val Leu Thr Gly 20 25 30 Phe Leu His Gln Pro Asp Cys Lys Ile Pro Leu Phe Leu Ala Phe Leu 35 40 45 Val Ile Tyr Leu Ile Thr Ile Met Gly Asn Leu Gly Leu Ile Val Leu 50 55 60 Ile Trp Lys Asp Pro His Leu His Ile Pro Met Tyr Leu Phe Leu Gly 65 70 75 80 Ser Leu Ala Phe Val Asp Ala Ser Leu Ser Ser Thr Val Thr Pro Lys 85 90 95 Met Leu Ile Asn Phe Leu Ala Lys Ser Lys Met Ile Ser Leu Ser Glu 100 105 110 Cys Met Val Gln Phe Phe Ser Leu Val Thr Thr Val Thr Thr Glu Cys 115 120 125 Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys 130 135 140 Ala Leu Leu Tyr Pro Val Ile Met Thr Asn Glu Leu Cys Ile Gln Leu 145 150 155 160 Leu Val Leu Ser Phe Ile Gly Gly Leu Leu His Ala Leu Ile His Glu 165 170 175 Ala Phe Ser Phe Arg Leu Thr Phe Cys Asn Ser Asn Ile Ile Gln His 180 185 190 Phe Tyr Cys Asp Ile Ile Pro Leu Leu Lys Ile Ser Cys Thr Asp Ser 195 200 205 Ser Ile Asn Phe Leu Met Val Phe Ile Phe Ala Gly Ser Val Gln Val 210 215 220 Phe Thr Ile Gly Thr Ile Leu Ile Ser Tyr Thr Ile Ile Leu Phe Thr 225 230 235 240 Ile Leu Glu Lys Lys Ser Ile Lys Gly Ile Arg Lys Ala Val Ser Thr 245 250 255 Cys Gly Ala His Leu Leu Ser Val Ser Leu Tyr Tyr Gly Pro Leu Thr 260 265 270 Phe Lys Tyr Leu Gly Ser Ala Ser Pro Gln Ala Asp Asp Gln Asp Met 275 280 285 Met Glu Ser Leu Phe Tyr Thr Val Ile Val Pro Leu Leu Asn Pro Met 290 295 300 Ile Tyr Ser Leu Arg Asn Lys Gln Val Ile Ala Ser Phe Thr Lys Met 305 310 315 320 Phe Lys Ser Asn Val 325 <210> 309 <211> 975 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(975) <400> 309 atg ccc agt gaa gtc ctg ggc aga aga atg atg tgg gaa aac tgg aca 48 Met Pro Ser Glu Val Leu Gly Arg Arg Met Met Trp Glu Asn Trp Thr 1 5 10 15 att gtc agt gaa ttt gtt ctc gtg agc ttc tca gcc ctg tcc act gag 96 Ile Val Ser Glu Phe Val Leu Val Ser Phe Ser Ala Leu Ser Thr Glu 20 25 30 ctt cag gct cta ctg ttt ctc ctt ttc ttg acc att tac ttg gtt act 144 Leu Gln Ala Leu Leu Phe Leu Leu Phe Leu Thr Ile Tyr Leu Val Thr 35 40 45 tta atg ggc aat gtc ctc atc atc ctg gtc act ata gct gac tct gca 192 Leu Met Gly Asn Val Leu Ile Ile Leu Val Thr Ile Ala Asp Ser Ala 50 55 60 cta caa agt cct atg tac ttc ttc ctc aga aac ttg tcc ttc ctg gag 240 Leu Gln Ser Pro Met Tyr Phe Phe Leu Arg Asn Leu Ser Phe Leu Glu 65 70 75 80 ata ggt ttc aac ttg gtc att gtg ccc aag atg ctg ggg acc ctg atc 288 Ile Gly Phe Asn Leu Val Ile Val Pro Lys Met Leu Gly Thr Leu Ile 85 90 95 att caa gac aca acc atc tcc ttc ctt gga tgt gcc act cag atg tat 336 Ile Gln Asp Thr Thr Ile Ser Phe Leu Gly Cys Ala Thr Gln Met Tyr 100 105 110 ttc ttc ttc ttt ttt ggg gct gct gag tgc tgc ctc ctg gcc acc atg 384 Phe Phe Phe Phe Phe Gly Ala Ala Glu Cys Cys Leu Leu Ala Thr Met 115 120 125 gca tat gac cgc tac gtg gcc atc tgt gac ccc ttg cac tac cca gtc 432 Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asp Pro Leu His Tyr Pro Val 130 135 140 atc atg ggc cac ata tcc tgt gcc cag ctg gca gct gcc tct tgg ttc 480 Ile Met Gly His Ile Ser Cys Ala Gln Leu Ala Ala Ala Ser Trp Phe 145 150 155 160 tca ggg ttt tca gtg gcc act gtg caa acc aca tgg att ttc agt ttc 528 Ser Gly Phe Ser Val Ala Thr Val Gln Thr Thr Trp Ile Phe Ser Phe 165 170 175 cct ttt tgt ggc ccc aac agg gtg aac cac ttc ttc tgt gac agc cct 576 Pro Phe Cys Gly Pro Asn Arg Val Asn His Phe Phe Cys Asp Ser Pro 180 185 190 cct gtt att gca ctg gtc tgt gct gac acc tct gtg ttt gaa ctg gag 624 Pro Val Ile Ala Leu Val Cys Ala Asp Thr Ser Val Phe Glu Leu Glu 195 200 205 gct ctg aca gcc act gtc cca ttc att ctc ttt cct ttc ttg ctg atc 672 Ala Leu Thr Ala Thr Val Pro Phe Ile Leu Phe Pro Phe Leu Leu Ile 210 215 220 ctg gga tcc tat gtc cgc atc ctc tcc act atc ttc agg atg ccg tca 720 Leu Gly Ser Tyr Val Arg Ile Leu Ser Thr Ile Phe Arg Met Pro Ser 225 230 235 240 gct gag ggg aaa cat cag gca ttc tcc acc tgt tcc gcc cac ctc ttg 768 Ala Glu Gly Lys His Gln Ala Phe Ser Thr Cys Ser Ala His Leu Leu 245 250 255 gtt gtc tct ctc ttc tat agc act gcc atc ctc acg tat ttc cga ccc 816 Val Val Ser Leu Phe Tyr Ser Thr Ala Ile Leu Thr Tyr Phe Arg Pro 260 265 270 caa tcc agt gcc tct tct gag agc aag aag ctg ctg tca ctc tct tcc 864 Gln Ser Ser Ala Ser Ser Glu Ser Lys Lys Leu Leu Ser Leu Ser Ser 275 280 285 aca gtg gtg act ccc atg ttg aac ccc atc atc tac agc tca agg aat 912 Thr Val Val Thr Pro Met Leu Asn Pro Ile Ile Tyr Ser Ser Arg Asn 290 295 300 aaa gaa gtg aag gct gca ctg aag cgg ctt atc cac agg acc ctg ggc 960 Lys Glu Val Lys Ala Ala Leu Lys Arg Leu Ile His Arg Thr Leu Gly 305 310 315 320 tct cag aaa cta tga 975 Ser Gln Lys Leu 325 <210> 310 <211> 324 <212> PRT <213> Homo sapiens <400> 310 Met Pro Ser Glu Val Leu Gly Arg Arg Met Met Trp Glu Asn Trp Thr 1 5 10 15 Ile Val Ser Glu Phe Val Leu Val Ser Phe Ser Ala Leu Ser Thr Glu 20 25 30 Leu Gln Ala Leu Leu Phe Leu Leu Phe Leu Thr Ile Tyr Leu Val Thr 35 40 45 Leu Met Gly Asn Val Leu Ile Ile Leu Val Thr Ile Ala Asp Ser Ala 50 55 60 Leu Gln Ser Pro Met Tyr Phe Phe Leu Arg Asn Leu Ser Phe Leu Glu 65 70 75 80 Ile Gly Phe Asn Leu Val Ile Val Pro Lys Met Leu Gly Thr Leu Ile 85 90 95 Ile Gln Asp Thr Thr Ile Ser Phe Leu Gly Cys Ala Thr Gln Met Tyr 100 105 110 Phe Phe Phe Phe Phe Gly Ala Ala Glu Cys Cys Leu Leu Ala Thr Met 115 120 125 Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asp Pro Leu His Tyr Pro Val 130 135 140 Ile Met Gly His Ile Ser Cys Ala Gln Leu Ala Ala Ala Ser Trp Phe 145 150 155 160 Ser Gly Phe Ser Val Ala Thr Val Gln Thr Thr Trp Ile Phe Ser Phe 165 170 175 Pro Phe Cys Gly Pro Asn Arg Val Asn His Phe Phe Cys Asp Ser Pro 180 185 190 Pro Val Ile Ala Leu Val Cys Ala Asp Thr Ser Val Phe Glu Leu Glu 195 200 205 Ala Leu Thr Ala Thr Val Pro Phe Ile Leu Phe Pro Phe Leu Leu Ile 210 215 220 Leu Gly Ser Tyr Val Arg Ile Leu Ser Thr Ile Phe Arg Met Pro Ser 225 230 235 240 Ala Glu Gly Lys His Gln Ala Phe Ser Thr Cys Ser Ala His Leu Leu 245 250 255 Val Val Ser Leu Phe Tyr Ser Thr Ala Ile Leu Thr Tyr Phe Arg Pro 260 265 270 Gln Ser Ser Ala Ser Ser Glu Ser Lys Lys Leu Leu Ser Leu Ser Ser 275 280 285 Thr Val Val Thr Pro Met Leu Asn Pro Ile Ile Tyr Ser Ser Arg Asn 290 295 300 Lys Glu Val Lys Ala Ala Leu Lys Arg Leu Ile His Arg Thr Leu Gly 305 310 315 320 Ser Gln Lys Leu <210> 311 <211> 843 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(843) <400> 311 atg gca att agg aac cat tcc acc ctc cac aaa ccc atg tac ttt ttt 48 Met Ala Ile Arg Asn His Ser Thr Leu His Lys Pro Met Tyr Phe Phe 1 5 10 15 cta gct aat atg tcc ttt ctg gag atc tgg tat gtc act gtc act att 96 Leu Ala Asn Met Ser Phe Leu Glu Ile Trp Tyr Val Thr Val Thr Ile 20 25 30 ccc aag atg ctt gct ggc ttt gtt gga tcc aaa cag gat cat gga cag 144 Pro Lys Met Leu Ala Gly Phe Val Gly Ser Lys Gln Asp His Gly Gln 35 40 45 cta atc tcc ttt gag gga tgc atg aca cag ctc tac ttt ttc ctt ggc 192 Leu Ile Ser Phe Glu Gly Cys Met Thr Gln Leu Tyr Phe Phe Leu Gly 50 55 60 ttg ggc tgc act gag tgt gtc ctt ctc gct gtt atg gcc tat gat cgc 240 Leu Gly Cys Thr Glu Cys Val Leu Leu Ala Val Met Ala Tyr Asp Arg 65 70 75 80 tat atg gcc atc tgc tat cct ctc cac tac cca gtc att gtc agt ggc 288 Tyr Met Ala Ile Cys Tyr Pro Leu His Tyr Pro Val Ile Val Ser Gly 85 90 95 cgg ctg tgt gtg cag atg gct gct ggc tct tgg gct gga ggt ttt ggc 336 Arg Leu Cys Val Gln Met Ala Ala Gly Ser Trp Ala Gly Gly Phe Gly 100 105 110 atc tcc atg gtc aaa gtt ttt ctt att tct ggc ctc tct tac tgt ggc 384 Ile Ser Met Val Lys Val Phe Leu Ile Ser Gly Leu Ser Tyr Cys Gly 115 120 125 ccc aac atc atc aac cac ttt ttc tgt gat gtc tct cca ttg ctc aac 432 Pro Asn Ile Ile Asn His Phe Phe Cys Asp Val Ser Pro Leu Leu Asn 130 135 140 ctc tca tgc act gat atg tcc aca gca gag ctt aca gat ttc atc ctg 480 Leu Ser Cys Thr Asp Met Ser Thr Ala Glu Leu Thr Asp Phe Ile Leu 145 150 155 160 gcc att ttt att ctt cta ggg cca ctc tct gtc act ggg gcc tcc tat 528 Ala Ile Phe Ile Leu Leu Gly Pro Leu Ser Val Thr Gly Ala Ser Tyr 165 170 175 gtg gcc att act ggt gct gtg atg cac att cct tcg gct gct gga cgc 576 Val Ala Ile Thr Gly Ala Val Met His Ile Pro Ser Ala Ala Gly Arg 180 185 190 tat aag gcc ttt tcc acc tgt gcc tct cat ctc act gtt gtg ata atc 624 Tyr Lys Ala Phe Ser Thr Cys Ala Ser His Leu Thr Val Val Ile Ile 195 200 205 ttc tat gca gcc agt atc ttc atc tat gct cgg cca aag gca ctc tca 672 Phe Tyr Ala Ala Ser Ile Phe Ile Tyr Ala Arg Pro Lys Ala Leu Ser 210 215 220 gct ttt gac acc aac aag ttg tct ctg tac tgt atg ctg tca ttg tac 720 Ala Phe Asp Thr Asn Lys Leu Ser Leu Tyr Cys Met Leu Ser Leu Tyr 225 230 235 240 cat tgc tca atc cca tca ttt act gcc tgc gca atc aag agg tca aga 768 His Cys Ser Ile Pro Ser Phe Thr Ala Cys Ala Ile Lys Arg Ser Arg 245 250 255 gag ccc tat gct gta ctc tgc acc ctg tac cag cac cag gat cct gac 816 Glu Pro Tyr Ala Val Leu Cys Thr Leu Tyr Gln His Gln Asp Pro Asp 260 265 270 ccc aag aaa gct agc aga aat gta tag 843 Pro Lys Lys Ala Ser Arg Asn Val 275 280 <210> 312 <211> 280 <212> PRT <213> Homo sapiens <400> 312 Met Ala Ile Arg Asn His Ser Thr Leu His Lys Pro Met Tyr Phe Phe 1 5 10 15 Leu Ala Asn Met Ser Phe Leu Glu Ile Trp Tyr Val Thr Val Thr Ile 20 25 30 Pro Lys Met Leu Ala Gly Phe Val Gly Ser Lys Gln Asp His Gly Gln 35 40 45 Leu Ile Ser Phe Glu Gly Cys Met Thr Gln Leu Tyr Phe Phe Leu Gly 50 55 60 Leu Gly Cys Thr Glu Cys Val Leu Leu Ala Val Met Ala Tyr Asp Arg 65 70 75 80 Tyr Met Ala Ile Cys Tyr Pro Leu His Tyr Pro Val Ile Val Ser Gly 85 90 95 Arg Leu Cys Val Gln Met Ala Ala Gly Ser Trp Ala Gly Gly Phe Gly 100 105 110 Ile Ser Met Val Lys Val Phe Leu Ile Ser Gly Leu Ser Tyr Cys Gly 115 120 125 Pro Asn Ile Ile Asn His Phe Phe Cys Asp Val Ser Pro Leu Leu Asn 130 135 140 Leu Ser Cys Thr Asp Met Ser Thr Ala Glu Leu Thr Asp Phe Ile Leu 145 150 155 160 Ala Ile Phe Ile Leu Leu Gly Pro Leu Ser Val Thr Gly Ala Ser Tyr 165 170 175 Val Ala Ile Thr Gly Ala Val Met His Ile Pro Ser Ala Ala Gly Arg 180 185 190 Tyr Lys Ala Phe Ser Thr Cys Ala Ser His Leu Thr Val Val Ile Ile 195 200 205 Phe Tyr Ala Ala Ser Ile Phe Ile Tyr Ala Arg Pro Lys Ala Leu Ser 210 215 220 Ala Phe Asp Thr Asn Lys Leu Ser Leu Tyr Cys Met Leu Ser Leu Tyr 225 230 235 240 His Cys Ser Ile Pro Ser Phe Thr Ala Cys Ala Ile Lys Arg Ser Arg 245 250 255 Glu Pro Tyr Ala Val Leu Cys Thr Leu Tyr Gln His Gln Asp Pro Asp 260 265 270 Pro Lys Lys Ala Ser Arg Asn Val 275 280 <210> 313 <211> 972 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(972) <400> 313 atg tgg cag aag aat cag acc tct ctg gca gac ttc atc ctt gag ggg 48 Met Trp Gln Lys Asn Gln Thr Ser Leu Ala Asp Phe Ile Leu Glu Gly 1 5 10 15 ctc ttc gat gac tcc ctt acc cac ctt ttc ctt ttc tcc ttg acc atg 96 Leu Phe Asp Asp Ser Leu Thr His Leu Phe Leu Phe Ser Leu Thr Met 20 25 30 gtg gtc ttc ctt att gcg gtg agt ggc aac acc ctc acc att ctc ctc 144 Val Val Phe Leu Ile Ala Val Ser Gly Asn Thr Leu Thr Ile Leu Leu 35 40 45 atc tgc att gat ccc cag ctt cat aca cca atg tat ttc ctg ctc agc 192 Ile Cys Ile Asp Pro Gln Leu His Thr Pro Met Tyr Phe Leu Leu Ser 50 55 60 cag ctc tcc ctc atg gat ctg atg cat gtc tcc aca atc atc ctg aag 240 Gln Leu Ser Leu Met Asp Leu Met His Val Ser Thr Ile Ile Leu Lys 65 70 75 80 atg gct acc aac tac cta tct ggc aag aaa tct atc tcc ttt gtg ggc 288 Met Ala Thr Asn Tyr Leu Ser Gly Lys Lys Ser Ile Ser Phe Val Gly 85 90 95 tgt gca acc cag cac ttc ctc tat ttg tgt cta ggt ggt gct gaa tgt 336 Cys Ala Thr Gln His Phe Leu Tyr Leu Cys Leu Gly Gly Ala Glu Cys 100 105 110 ttt ctc tta gct gtc atg tcc tat gac cgc tat gtt gcc atc tgt cat 384 Phe Leu Leu Ala Val Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 cca ctg cgc tat gct gtg ctc atg aac aag aag gtg gga ctg atg atg 432 Pro Leu Arg Tyr Ala Val Leu Met Asn Lys Lys Val Gly Leu Met Met 130 135 140 gct gtc atg tca tgg ttg ggg gca tcc gtg aac tcc cta att cac atg 480 Ala Val Met Ser Trp Leu Gly Ala Ser Val Asn Ser Leu Ile His Met 145 150 155 160 gcg atc ttg atg cac ttc cct ttc tgt ggg cct cgg aaa gtc tac cac 528 Ala Ile Leu Met His Phe Pro Phe Cys Gly Pro Arg Lys Val Tyr His 165 170 175 ttc tac tgt gag ttc cca gct gtt gtg aag ttg gta tgt ggc gac atc 576 Phe Tyr Cys Glu Phe Pro Ala Val Val Lys Leu Val Cys Gly Asp Ile 180 185 190 act gtg tat gag acc aca gtg tac atc agc agc att ctc ctc ctc ctc 624 Thr Val Tyr Glu Thr Thr Val Tyr Ile Ser Ser Ile Leu Leu Leu Leu 195 200 205 ccc atc ttc ctg att tct aca tcc tat gtc ttc atc ctt caa agt gtc 672 Pro Ile Phe Leu Ile Ser Thr Ser Tyr Val Phe Ile Leu Gln Ser Val 210 215 220 att cag atg cgc tca tct ggg agc aag aga aat gcc ttt gcc act tgt 720 Ile Gln Met Arg Ser Ser Gly Ser Lys Arg Asn Ala Phe Ala Thr Cys 225 230 235 240 ggc tcc cac ctc acg gtg gtt tct ctt tgg ttt ggt gcc tgc atc ttc 768 Gly Ser His Leu Thr Val Val Ser Leu Trp Phe Gly Ala Cys Ile Phe 245 250 255 tcc tac atg aga ccc agg tcc cag tgc act cta ttg cag aac aaa gtt 816 Ser Tyr Met Arg Pro Arg Ser Gln Cys Thr Leu Leu Gln Asn Lys Val 260 265 270 ggt tct gtg ttc tac agc atc att acg ccc aca ttg aat tct ctg att 864 Gly Ser Val Phe Tyr Ser Ile Ile Thr Pro Thr Leu Asn Ser Leu Ile 275 280 285 tat act ctc cgg aat aaa gat gta gct aag gct ctg aga aga gtg ctg 912 Tyr Thr Leu Arg Asn Lys Asp Val Ala Lys Ala Leu Arg Arg Val Leu 290 295 300 agg aga gat gtt atc acc cag tgc att caa cga ctg caa ttg tgg ttg 960 Arg Arg Asp Val Ile Thr Gln Cys Ile Gln Arg Leu Gln Leu Trp Leu 305 310 315 320 ccc cga gtg tag 972 Pro Arg Val <2 10> 314 <211> 323 <212> PRT <213> Homo sapiens <400> 314 Met Trp Gln Lys Asn Gln Thr Ser Leu Ala Asp Phe Ile Leu Glu Gly 1 5 10 15 Leu Phe Asp Asp Ser Leu Thr His Leu Phe Leu Phe Ser Leu Thr Met 20 25 30 Val Val Phe Leu Ile Ala Val Ser Gly Asn Thr Leu Thr Ile Leu Leu 35 40 45 Ile Cys Ile Asp Pro Gln Leu His Thr Pro Met Tyr Phe Leu Leu Ser 50 55 60 Gln Leu Ser Leu Met Asp Leu Met His Val Ser Thr Ile Ile Leu Lys 65 70 75 80 Met Ala Thr Asn Tyr Leu Ser Gly Lys Lys Ser Ile Ser Phe Val Gly 85 90 95 Cys Ala Thr Gln His Phe Leu Tyr Leu Cys Leu Gly Gly Ala Glu Cys 100 105 110 Phe Leu Leu Ala Val Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu Arg Tyr Ala Val Leu Met Asn Lys Lys Val Gly Leu Met Met 130 135 140 Ala Val Met Ser Trp Leu Gly Ala Ser Val Asn Ser Leu Ile His Met 145 150 155 160 Ala Ile Leu Met His Phe Pro Phe Cys Gly Pro Arg Lys Val Tyr His 165 170 175 Phe Tyr Cys Glu Phe Pro Ala Val Val Lys Leu Val Cys Gly Asp Ile 180 185 190 Thr Val Tyr Glu Thr Thr Val Tyr Ile Ser Ser Ile Leu Leu Leu Leu 195 200 205 Pro Ile Phe Leu Ile Ser Thr Ser Tyr Val Phe Ile Leu Gln Ser Val 210 215 220 Ile Gln Met Arg Ser Ser Gly Ser Lys Arg Asn Ala Phe Ala Thr Cys 225 230 235 240 Gl y Ser His Leu Thr Val Val Ser Leu Trp Phe Gly Ala Cys Ile Phe 245 250 255 Ser Tyr Met Arg Pro Arg Ser Gln Cys Thr Leu Leu Gln Asn Lys Val 260 265 270 Gly Ser Val Phe Tyr Ser Ile Ile Thr Pro Thr Leu Asn Ser Leu Ile 275 280 285 Tyr Thr Leu Arg Asn Lys Asp Val Ala Lys Ala Leu Arg Arg Val Leu 290 295 300 Arg Arg Asp Val Ile Thr Gln Cys Ile Gln Arg Leu Gln Leu Trp Leu 305 310 315 320 Pro Arg Val <210> 315 <211> 990 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(990) <400> 315 atg act ttg gtt tct ttt ttc tct ttc ctc tcc aag cca ttg ata atg 48 Met Thr Leu Val Ser Phe Phe Ser Phe Leu Ser Lys Pro Leu Ile Met 1 5 10 15 ctc ctt agc aat tca agc tgg agg cta tcc cag cct tct ttt ctc ctg 96 Leu Leu Ser Asn Ser Ser Trp Arg Leu Ser Gln Pro Ser Phe Leu Leu 20 25 30 gta ggg att cca ggt tta gag gaa agc cag cac tgg att gca ctg ccc 144 Val Gly Ile Pro Gly Leu Glu Glu Ser Gln His Trp Ile Ala Leu Pro 35 40 45 ctg ggc atc ctt tac ctc ctt gct tta gtg ggc aat gtt acc att ctc 192 Leu Gly Ile Leu Tyr Leu Leu Ala Leu Val Gly Asn Val Thr Ile Leu 50 55 60 ttc atc atc tgg atg gac cca tcc ttg cac caa tct atg tac ctc ttc 240 Phe Ile Ile Trp Met Asp Pro Ser Leu His Gln Ser Met Tyr Leu Phe 65 70 75 80 ctg tcc atg cta gct gcc atc gac ctg gtt ctg gcc tcc tcc act gca 288 Leu Ser Met Leu Ala Ala Ile Asp Leu Val Leu Ala Ser Ser Thr Ala 85 90 95 ccc aaa gcc ctt gca gtg ctc ctg gtt cat gcc cac gag att ggg tac 336 Pro Lys Ala Leu Ala Val Leu Leu Val His Ala His Glu Ile Gly Tyr 100 105 110 atc gtc tgc ctg atc cag atg ttc ttc atc cat gca ttc tcc tcc atg 384 Ile Val Cys Leu Ile Gln Met Phe Phe Ile His Ala Phe Ser Ser Met 115 120 125 gag tca ggg gta ctt gtg gcc atg gct ctg gat cgc tat gta gcc att 432 Glu Ser Gly Val Leu Val Ala Met Ala Leu Asp Arg Tyr Val Ala Ile 130 135 140 tgt cac ccc ttg cac cat tcc aca atc ctg cat cca ggg gtc ata ggg 480 Cys His Pro Leu His His Ser Thr Ile Leu His Pro Gly Val Ile Gly 145 150 155 160 cgc atc gga atg gtg gtg ctg gtg agg gga tta cta ctc ctt atc ccc 528 Arg Ile Gly Met Val Val Leu Val Arg Gly Leu Leu Leu Leu Ile Pro 165 170 175 ttc ccc att ttg ttg gga aca ctt atc ttc tgc caa gcc acc atc ata 576 Phe Pro Ile Leu Leu Gly Thr Leu Ile Phe Cys Gln Ala Thr Ile Ile 180 185 190 ggc cat gcc tat tgt gaa cat atg gct gtt gtg aaa ctt gcc tgc tca 624 Gly His Ala Tyr Cys Glu His Met Ala Val Val Lys Leu Ala Cys Ser 195 200 205 gaa acc aca gtc aat cga gct tat ggg ctg act atg gcc ttg ctt gtg 672 Glu Thr Thr Val Asn Arg Ala Tyr Gly Leu Thr Met Ala Leu Leu Val 210 215 220 att ggg ctg gat gtt ctg gcc att ggt gtt tcc tat gcc cac atc ctc 720 Ile Gly Leu Asp Val Leu Ala Ile Gly Val Ser Tyr Ala His Ile Leu 225 230 235 240 cag gca gtg ctg aag gta cca ggg agt gag gcc cga ctt aag gcg ttt 768 Gln Ala Val Leu Lys Val Pro Gly Ser Glu Ala Arg Leu Lys Ala Phe 245 250 255 agc aca tgt ggc tct cat att tgt gtc atc ctg gtc ttc tat gtc cct 816 Ser Thr Cys Gly Ser His Ile Cys Val Ile Leu Val Phe Tyr Val Pro 260 265 270 gga att ttc tcc ttc ctc act cac cgc ttt ggt cat cat gta ccc cat 864 Gly Ile Phe Ser Phe Leu Thr His Arg Phe Gly His His Val Pro His 275 280 285 cat gtc cat gtt ctt ctg gcc aca cgg tat ctc ctc atg cca cct gcg 912 His Val His Val Leu Leu Ala Thr Arg Tyr Leu Leu Met Pro Pro Ala 290 295 300 ctc aat cct ctt gtc tat gga gtg aag act cag cag atc cgc cag cga 960 Leu Asn Pro Leu Val Tyr Gly Val Lys Thr Gln Gln Ile Arg Gln Arg 305 310 315 320 gt g ctc aga gtg ttt aca caa aag gat tga 990 Val Leu Arg Val Phe Thr Gln Lys Asp 325 330 <210> 316 <211> 329 <212> PRT <213> Homo sapiens <400> 316 Met Thr Leu Val Ser Phe Phe Ser Phe Leu Ser Lys Pro Leu Ile Met 1 5 10 15 Leu Leu Ser Asn Ser Ser Trp Arg Leu Ser Gln Pro Ser Phe Leu Leu 20 25 30 Val Gly Ile Pro Gly Leu Glu Glu Ser Gln His Trp Ile Ala Leu Pro 35 40 45 Leu Gly Ile Leu Tyr Leu Leu Ala Leu Val Gly Asn Val Thr Ile Leu 50 55 60 Phe Ile Ile Trp Met Asp Pro Ser Leu His Gln Ser Met Tyr Leu Phe 65 70 75 80 Leu Ser Met Leu Ala Ala Ile Asp Leu Val Leu Ala Ser Ser Thr Ala 85 90 95 Pro Lys Ala Leu Ala Val Leu Leu Val His Ala His Glu Ile Gly Tyr 100 105 110 Ile Val Cys Leu Ile Gln Met Phe Phe Ile His Ala Phe Ser Ser Met 115 120 125 Glu Ser Gly Val Leu Val Ala Met Ala Leu Asp Arg Tyr Val Ala Ile 130 135 140 Cys His Pro Leu His His Ser Thr Ile Leu His Pro Gly Val Ile Gly 145 150 155 160 Arg Ile Gly Met Val Val Leu Val Arg Gly Leu Leu Leu Leu Ile Pro 165 170 175 Phe Pro Ile Leu Leu Gly Thr Leu Ile Phe Cys Gln Ala Thr Ile Ile 180 185 190 Gly His Ala Tyr Cys Glu His Met Ala Val Val Lys Leu Ala Cys Ser 195 200 205 Glu Thr Thr Val Asn Arg Ala Tyr Gly Leu Thr Met Ala Leu Leu Val 210 215 220 Ile Gly Leu Asp Val Leu Ala Ile Gly Val Ser Tyr Ala His Ile Leu 225 230 235 240 Gln Ala Val Leu Lys Val Pro Gly Ser Glu Ala Arg Leu Lys Ala Phe 245 250 255 Ser Thr Cys Gly Ser His Ile Cys Val Ile Leu Val Phe Tyr Val Pro 260 265 270 Gly Ile Phe Ser Phe Leu Thr His Arg Phe Gly His His Val Pro His 275 280 285 His Val His Val Leu Leu Ala Thr Arg Tyr Leu Leu Met Pro Pro Ala 290 295 300 Leu Asn Pro Leu Val Tyr Gly Val Lys Thr Gln Gln Ile Arg Gln Arg 305 310 315 320 Val Leu Arg Val Phe Thr Gln Lys Asp 325 <210> 317 <211> 960 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(960) <400> 317 atg aat ttg gat tct ttt ttc tct ttc ctc ctc aag tca ttg ata atg 48 Met Asn Leu Asp Ser Phe Phe Ser Phe Leu Leu Lys Ser Leu Ile Met 1 5 10 15 gca ctt agc aat tcc agc tgg agg cta ccc cag cct tct ttt ttc ctg 96 Ala Leu Ser Asn Ser Ser Trp Arg Leu Pro Gln Pro Ser Phe Phe Leu 20 25 30 gta gga att ccg ggt tta gag gaa agc cag cac tgg atc gca ctg ccc 144 Val Gly Ile Pro Gly Leu Glu Glu Ser Gln His Trp Ile Ala Leu Pro 35 40 45 ctg ggc atc ctt tac ctc ctt gct cta gtg ggc aat gtt acc att ctc 192 Leu Gly Ile Leu Tyr Leu Leu Ala Leu Val Gly Asn Val Thr Ile Leu 50 55 60 ttc atc atc tgg atg gac cca tcc ttg cac caa tct atg tac ctc ttc 240 Phe Ile Ile Trp Met Asp Pro Ser Leu His Gln Ser Met Tyr Leu Phe 65 70 75 80 ctg tcc atg cta gct gcc atc gac ctg gtt gtg gcc tcc tcc act gca 288 Leu Ser Met Leu Ala Ala Ile Asp Leu Val Val Ala Ser Ser Thr Ala 85 90 95 ccc aaa gcc ctt gca gtg ctc ctg gtt cgt gcc caa gag att ggt tac 336 Pro Lys Ala Leu Ala Val Leu Leu Val Arg Ala Gln Glu Ile Gly Tyr 100 105 110 act gtc tgc ctg atc cag atg ttc ttc acc cat gca ttc tcc tcc atg 384 Thr Val Cys Leu Ile Gln Met Phe Phe Thr His Ala Phe Ser Ser Met 115 120 125 gag tca ggg gta ctt gtg gcc atg gct ctg gat cgc tat gta gcc att 432 Glu Ser Gly Val Leu Val Ala Met Ala Leu Asp Arg Tyr Val Ala Ile 130 135 140 tgt cac ccc ttg cac cat tcc aca atc ctg cat cca ggg gtc ata ggg 480 Cys His Pro Leu His His Ser Thr Ile Leu His Pro Gly Val Ile Gly 145 150 155 160 cac atc gga atg gtg gtg ctg gtg cgg gga tta cta ctc ctc atc ccc 528 His Ile Gly Met Val Val Leu Val Arg Gly Leu Leu Leu Leu Ile Pro 165 170 175 ttc ctc att ctg ttg cga aaa ctt atc ttc tgc caa gcc acc atc ata 576 Phe Leu Ile Leu Leu Arg Lys Leu Ile Phe Cys Gln Ala Thr Ile Ile 180 185 190 ggc cat gcc tat tgt gaa cat atg gct gtt gtg aaa ctt gcc tgc tca 624 Gly His Ala Tyr Cys Glu His Met Ala Val Val Lys Leu Ala Cys Ser 195 200 205 gaa acc aca gtc aat cga gct tat ggg ctg act gtg gcc ttg ctt gtg 672 Glu Thr Thr Val Asn Arg Ala Tyr Gly Leu Thr Val Ala Leu Leu Val 210 215 220 gtt ggg ctg gat gtc ctg gcc att ggt gtt tcc tat gcc cac att ctc 720 Val Gly Leu Asp Val Leu Ala Ile Gly Val Ser Tyr Ala His Ile Leu 225 230 235 240 cag gca gtg ctg aag gta cca gga aat gag gcc cga ctt aag gcc ttt 768 Gln Ala Val Leu Lys Val Pro Gly Asn Glu Ala Arg Leu Lys Ala Phe 245 250 255 agc aca tgt ggc tct cat gtt tgt gtc atc ctg gtc ttc tat atc ccg 816 Ser Thr Cys Gly Ser His Val Cys Val Ile Leu Val Phe Tyr Ile Pro 260 265 270 gga atg ttc tcc ttc ctc act cac cgc ttt ggt cat cat gta ccc cat 864 Gly Met Phe Ser Phe Leu Thr His Arg Phe Gly His His Val Pro His 275 280 285 cac gtc cat gtt ctt ctg gcc ata ctg tat cgc ctt gtg cca cct gca 912 His Val His Val Leu Leu Ala Ile Leu Tyr Arg Leu Val Pro Pro Ala 290 295 300 ctc aat cct ctt gtc tat agg gtg aag acc cag aag atc cac cag tga 960 Leu Asn Pro Leu Val Tyr Arg Val Lys Thr Gln Lys Ile His Gln 305 310 315 320 <210> 318 <211> 319 <212> PRT <213> Homo sapiens <400> 318 Met Asn Leu Asp Ser Phe Phe Ser Phe Leu Leu Lys Ser Leu Ile Met 1 5 10 15 Ala Leu Ser Asn Ser Ser Trp Arg Leu Pro Gln Pro Ser Phe Phe Leu 20 25 30 Val Gly Ile Pro Gly Leu Glu Glu Ser Gln His Trp Ile Ala Leu Pro 35 40 45 Leu Gly Ile Leu Tyr Leu Leu Ala Leu Val Gly Asn Val Thr Ile Leu 50 55 60 Phe Ile Ile Trp Met Asp Pro Ser Leu His Gln Ser Met Tyr Leu Phe 65 70 75 80 Leu Ser Met Leu Ala Ala Ile Asp Leu Val Val Ala Ser Ser Thr Ala 85 90 95 Pro Lys Ala Leu Ala Val Leu Leu Val Arg Ala Gln Glu Ile Gly Tyr 100 105 110 Thr Val Cys Leu Ile Gln Met Phe Phe Thr His Ala Phe Ser Ser Met 115 120 125 Glu Ser Gly Val Leu Val Ala Met Ala Leu Asp Arg Tyr Val Ala Ile 130 135 140 Cys His Pro Leu His His Ser Thr Ile Leu His Pro Gly Val Ile Gly 145 150 155 160 His Ile Gly Met Val Val Leu Val Arg Gly Leu Leu Leu Leu Ile Pro 165 170 175 Phe Leu Ile Leu Leu Arg Lys Leu Ile Phe Cys Gln Ala Thr Ile Ile 180 185 190 Gly His Ala Tyr Cys Glu His Met Ala Val Val Lys Leu Ala Cys Ser 195 200 205 Glu Thr Thr Val Asn Arg Ala Tyr Gly Leu Thr Val Ala Leu Leu Val 210 215 220 Val Gly Leu Asp Val Leu Ala Ile Gly Val Ser Tyr Ala His Ile Leu 225 230 235 240 Gln Ala Val Leu Lys Val Pro Gly Asn Glu Ala Arg Leu Lys Ala Phe 245 250 255 Ser Thr Cys Gly Ser His Val Cys Val Ile Leu Val Phe Tyr Ile Pro 260 265 270 Gly Met Phe Ser Phe Leu Thr His Arg Phe Gly His His Val Pro His 275 280 285 His Val His Val Leu Leu Ala Ile Leu Tyr Arg Leu Val Pro Pro Ala 290 295 300 Leu Asn Pro Leu Val Tyr Arg Val Lys Thr Gln Lys Ile His Gln 305 310 315 <210> 319 <211> 951 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(951) <400> 319 atg gtt aac caa agc tcc ccc atg ggc ttc ctc ctt ctg ggc ttc tct 48 Met Val Asn Gln Ser Ser Pro Met Gly Phe Leu Leu Leu Gly Phe Ser 1 5 10 15 gaa cac cca gca ctg gaa agg act ctc ttt gtg gtt gtc ttc act tcc 96 Glu His Pro Ala Leu Glu Arg Thr Leu Phe Val Val Val Phe Thr Ser 20 25 30 tac ctc ttg acc ctg gtg ggc aac aca ctc atc atc ctg ctg tct gta 144 Tyr Leu Leu Thr Leu Val Gly Asn Thr Leu Ile Ile Leu Leu Ser Val 35 40 45 ctg tac ccc agg ctc cac tct cca atg tac ttt ttc ctc tct gac ctc 192 Leu Tyr Pro Arg Leu His Ser Pro Met Tyr Phe Phe Leu Ser Asp Leu 50 55 60 tcc ttc ttg gac ctc tgc ttt acc aca agt tgt gtc ccc cag atg ctg 240 Ser Phe Leu Asp Leu Cys Phe Thr Thr Ser Cys Val Pro Gln Met Leu 65 70 75 80 gtc aac ctc tgg ggc cca aag aag acc atc agc ttc ctg gga tgc tct 288 Val Asn Leu Trp Gly Pro Lys Lys Thr Ile Ser Phe Leu Gly Cys Ser 85 90 95 gtc cag ctc ttc atc ttc ctg tcc ctg ggg acc act gag tgc atc ctc 336 Val Gln Leu Phe Ile Phe Leu Ser Leu Gly Thr Thr Glu Cys Ile Leu 100 105 110 ctg aca gtg atg gcc ttt gac cga tac gtg gct gtc tgc cag ccc ctc 384 Leu Thr Val Met Ala Phe Asp Arg Tyr Val Ala Val Cys Gln Pro Leu 115 120 125 cac tat gcc acc atc atc cac ccc cgc ctg tgc tgg cag ctg gca tct 432 His Tyr Ala Thr Ile Ile His Pro Arg Leu Cys Trp Gln Leu Ala Ser 130 135 140 gtg gcc tgg gtt atg agt ctg gtt caa tcg ata gtc cag aca cca tcc 480 Val Ala Trp Val Met Ser Leu Val Gln Ser Ile Val Gln Thr Pro Ser 145 150 155 160 acc ctc cac ttg ccc ttc tgt ccc cac cag cag ata gat gac ttt tta 528 T hr Leu His Leu Pro Phe Cys Pro His Gln Gln Ile Asp Asp Phe Leu 165 170 175 tgt gag gtc cca tct ctg att cga ctc tcc tgt gga gat acc tcc tac 576 Cys Glu Val Pro Ser Leu Ile Arg Leu Ser Cys Gly Asp Thr Ser Tyr 180 185 190 aat gaa atc cag ttg gct gtg tcc agt gtc atc ttc gtg gtt gtg cct 624 Asn Glu Ile Gln Leu Ala Val Ser Ser Val Ile Phe Val Val Val Pro 195 200 205 ctc agc ctc atc ctt gcc tct tat gga gcc act gcc cag gca gtg ctg 672 Leu Ser Leu Ile Leu Ala Ser Tyr Gly Ala Thr Ala Gln Ala Val Leu 210 215 220 agg att aac tct gcc aca gca tgg aga aag gcc ttt ggg acc tgc tcc 720 Arg Ile Asn Ser Ala Thr Ala Trp Arg Lys Ala Phe Gly Thr Cys Ser 225 230 235 240 tcc cat ctc act gtg gtc acc ctc ttc tac agc tca gtc att gct gtc 768 Ser His Leu Thr Val Val Thr Leu Phe Tyr Ser Ser Val Ile Ala Val 245 250 255 tac ctc cag ccc aaa aat ccg tat gcc caa ggg agg ggc aag ttc ttt 816 Tyr Leu Gln Pro Lys Asn Pro Tyr Ala Gln Gly Arg Gly Lys Phe Phe 260 265 270 ggt ctc ttc tat gca gtg ggc act cct tca ctt aac cct ctc gta tac 864 Gly Leu Phe Tyr Ala Val Gly Thr Pro Ser Leu Asn Pro Leu Val Tyr 275 280 285 acc ctg agg aac aag gag ata aag cga gca ctc agg agg tta cta ggg 912 Thr Leu Arg Asn Lys Glu Ile Lys Arg Ala Leu Arg Arg Leu Leu Gly 290 295 300 aag gaa aga gac tcc agg gaa agc tgg aga gct gct taa 951 Lys Glu Arg Asp Ser Arg Glu Ser Trp Arg Ala Ala 305 310 315 <210> 320 <211> 316 <212> PRT <213> Homo sapiens <400> 320 Met Val Asn Gln Ser Ser Pro Met Gly Phe Leu Leu Leu Gly Phe Ser 1 5 10 15 Glu His Pro Ala Leu Glu Arg Thr Leu Phe Val Val Val Phe Thr Ser 20 25 30 Tyr Leu Leu Thr Leu Val Gly Asn Thr Leu Ile Ile Leu Leu Ser Val 35 40 45 Leu Tyr Pro Arg Leu His Ser Pro Met Tyr Phe Phe Leu Ser Asp Leu 50 55 60 Ser Phe Leu Asp Leu Cys Phe Thr Thr Ser Cys Val Pro Gln Met Leu 65 70 75 80 Val Asn Leu Trp Gly Pro Lys Lys Thr Ile Ser Phe Leu Gly Cys Ser 85 90 95 Val Gln Leu Phe Ile Phe Leu Ser Leu Gly Thr Thr Glu Cys Ile Leu 100 105 110 Leu Thr Val Met Ala Phe Asp Arg Tyr Val Ala Val Cys Gln Pro Leu 115 120 125 His Tyr Ala Thr Ile Ile His Pro Arg Leu Cys Trp Gln Leu Ala Ser 130 135 140 Val Ala Trp Val Met Ser Leu Val Gln Ser Ile Val Gln Thr Pro Ser 145 150 155 160 Thr Leu His Leu Pro Phe Cys Pro His Gln Gln Ile Asp Asp Phe Leu 165 170 175 Cys Glu Val Pro Ser Leu Ile Arg Leu Ser Cys Gly Asp Thr Ser Tyr 180 185 190 Asn Glu Ile Gln Leu Ala Val Ser Ser Val Ile Phe Val Val Val Pro 195 200 205 Leu Ser Leu Ile Leu Ala Ser Tyr Gly Ala Thr Ala Gln Ala Val Leu 210 215 220 A rg Ile Asn Ser Ala Thr Ala Trp Arg Lys Ala Phe Gly Thr Cys Ser 225 230 235 240 Ser His Leu Thr Val Val Thr Leu Phe Tyr Ser Ser Val Ile Ala Val 245 250 255 Tyr Leu Gln Pro Lys Asn Pro Tyr Ala Gln Gly Arg Gly Lys Phe Phe 260 265 270 Gly Leu Phe Tyr Ala Val Gly Thr Pro Ser Leu Asn Pro Leu Val Tyr 275 280 285 Thr Leu Arg Asn Lys Glu Ile Lys Arg Ala Leu Arg Arg Leu Leu Gly 290 295 300 Lys Glu Arg Asp Ser Arg Glu Ser Trp Arg Ala Ala 305 310 315 <210> 321 <211> 948 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(948) <400> 321 atg gag acg tgg gtg aac cag tcc tac aca gat ggc ttc ttc ctc tta 48 Met Glu Thr Trp Val Asn Gln Ser Tyr Thr Asp Gly Phe Phe Leu Leu 1 5 10 15 ggc atc ttc tcc cac agt act gct gac ctt gtc ctc ttc tcc gtg gtt 96 Gly Ile Phe Ser His Ser Thr Ala Asp Leu Val Leu Phe Ser Val Val 20 25 30 atg gcg gtc ttc aca gtg gcc ctc tgt ggg aat gtc ctc ctc atc ttc 144 Met Ala Val Phe Thr Val Ala Leu Cys Gly Asn Val Leu Leu Ile Phe 35 40 45 ctc atc tac atg gac cct cac ctt cac acc ccc atg tac ttc ttc ctc 192 Leu Ile Tyr Met Asp Pro His Leu His Thr Pro Met Tyr Phe Phe Leu 50 55 60 agc cag ctc tcc ctc atg gac ctc atg ttg gtc tgt acc aat gtg cca 240 Ser Gln Leu Ser Leu Met Asp Leu Met Leu Val Cys Thr Asn Val Pro 65 70 75 80 aag atg gca gcc aac ttc ctg tct ggc agg aag tcc atc tcc ttt gtg 288 Lys Met Ala Ala Asn Phe Leu Ser Gly Arg Lys Ser Ile Ser Phe Val 85 90 95 ggc tgt ggc ata caa att ggc ctc ttt gtc tgt ctt gtg gga tct gag 336 Gly Cys Gly Ile Gln Ile Gly Leu Phe Val Cys Leu Val Gly Ser Glu 100 105 110 g gg ctc ttg ctg gga ctc atg gct tat gac cgc tat gtg gcc att agc 384 Gly Leu Leu Leu Gly Leu Met Ala Tyr Asp Arg Tyr Val Ala Ile Ser 115 120 125 cac cca ctt cac tat ccc atc ctc atg aat cag agg gtc tgt ctc cag 432 His Pro Leu His Tyr Pro Ile Leu Met Asn Gln Arg Val Cys Leu Gln 130 135 140 att act ggg agc tcc tgg gcc ttt ggg ata atc gat ggc ttg atc cag 480 Ile Thr Gly Ser Ser Trp Ala Phe Gly Ile Ile Asp Gly Leu Ile Gln 145 150 155 160 atg gtg gta gta atg aat ttc ccc tac tgt ggc ttg agg aag gtg aac 528 Met Val Val Val Met Asn Phe Pro Tyr Cys Gly Leu Arg Lys Val Asn 165 170 175 cat ttc ttc tgt gag atg cta tcc ttg ttg aag ctg gcc tgt gta gac 576 His Phe Phe Cys Glu Met Leu Ser Leu Leu Lys Leu Ala Cys Val Asp 180 185 190 aca tcc ctg ttt gag aag gtg ata ttt gct tgc tgt gtc ttc atg ctt 624 Thr Ser Leu Phe Glu Lys Val Ile Phe Ala Cys Cys Val Phe Met Leu 195 200 205 ctc ttc cca ttc tcc atc atc gtg gcc tcc tat gct cac att cta ggg 672 Leu Phe Pro Phe Ser Ile Ile Val Ala Ser Tyr Ala His Ile Leu Gly 210 215 220 act gtg ctg caa atg cac tct gct cag gcc tgg aaa aag gcc ctg gcc 720 Thr Val Leu Gln Met His Ser Ala Gln Ala Trp Lys Lys Ala Leu Ala 225 230 235 240 acc tgc tcc tcc cac ctg aca gct gtc acc ctc ttc tat ggg gca gcc 768 Thr Cys Ser Ser His Leu Thr Ala Val Thr Leu Phe Tyr Gly Ala Ala 245 250 255 atg ttc atc tac ctg agg cct agg cac tac cgg gcc ccc agc cat gac 816 Met Phe Ile Tyr Leu Arg Pro Arg His Tyr Arg Ala Pro Ser His Asp 260 265 270 aag gtg gcc tct atc ttc tac acg gtc ctt act ccc atg ctc aac ccc 864 Lys Val Ala Ser Ile Phe Tyr Thr Val Leu Thr Pro Met Leu Asn Pro 275 280 285 ctc att tac agc ttg agg aac agg gag gtg atg ggg gca ctg agg aag 912 Leu Ile Tyr Ser Leu Arg Asn Arg Glu Val Met Gly Ala Leu Arg Lys 290 295 300 ggg ctg gac cgc tgc agg atc ggc agc cag cac tga 948 Gly Leu Asp Arg Cys Arg Ile Gly Ser Gln His 305 310 315 <210> 322 <211> 315 <212> PRT <213> Homo sapiens <400> 322 Met Glu Thr Trp Val Asn Gln Ser Tyr Thr Asp Gly Phe Phe Leu Leu 1 5 10 15 Gly Ile Phe Ser His Ser Thr Ala Asp Leu Val Leu Phe Ser Val Val 20 25 30 Met Ala Val Phe Thr Val Ala Leu Cys Gly Asn Val Leu Leu Ile Phe 35 40 45 Leu Ile Tyr Met Asp Pro His Leu His Thr Pro Met Tyr Phe Phe Leu 50 55 60 Ser Gln Leu Ser Leu Met Asp Leu Met Leu Val Cys Thr Asn Val Pro 65 70 75 80 Lys Met Ala Ala Asn Phe Leu Ser Gly Arg Lys Ser Ile Ser Phe Val 85 90 95 Gly Cys Gly Ile Gln Ile Gly Leu Phe Val Cys Leu Val Gly Ser Glu 100 105 110 Gly Leu Leu Leu Gly Leu Met Ala Tyr Asp Arg Tyr Val Ala Ile Ser 115 120 125 His Pro Leu His Tyr Pro Ile Leu Met Asn Gln Arg Val Cys Leu Gln 130 135 140 Ile Thr Gly Ser Ser Trp Ala Phe Gly Ile Ile Asp Gly Leu Ile Gln 145 150 155 160 Met Val Val Val Met Asn Phe Pro Tyr Cys Gly Leu Arg Lys Val Asn 165 170 175 His Phe Phe Cys Glu Met Leu Ser Leu Leu Lys Leu Ala Cys Val Asp 180 185 190 Thr Ser Leu Phe Glu Lys Val Ile Phe Ala Cys Cys Val Phe Met Leu 195 200 205 Leu Phe Pro Phe Ser Ile Ile Val Ala Ser Tyr Ala His Ile Leu Gly 210 215 220 Thr Val Leu Gln Met His Ser Ala Gln Ala Trp Lys Lys Ala Leu Ala 225 230 235 240 Thr Cys Ser Ser His Leu Thr Ala Val Thr Leu Phe Tyr Gly Ala Ala 245 250 255 Met Phe Ile Tyr Leu Arg Pro Arg His Tyr Arg Ala Pro Ser His Asp 260 265 270 Lys Val Ala Ser Ile Phe Tyr Thr Val Leu Thr Pro Met Leu Asn Pro 275 280 285 Leu Ile Tyr Ser Leu Arg Asn Arg Glu Val Met Gly Ala Leu Arg Lys 290 295 300 Gly Leu Asp Arg Cys Arg Ile Gly Ser Gln His 305 310 315 <210> 323 <211> 759 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(759) <400> 323 atg tac ctg ttc ctc agc cac ttg gct ttt gtg gac ata ggg ctt gcc 48 Met Tyr Leu Phe Leu Ser His Leu Ala Phe Val Asp Ile Gly Leu Ala 1 5 10 15 aca gta gtc aca cct ata atg ctt atg gga ttc cta aga cgt gga aca 96 Thr Val Val Thr Pro Ile Met Leu Met Gly Phe Leu Arg Arg Gly Thr 20 25 30 gcc ctc cct gtc act agc tgt gaa gcc cag ctc tgt tct gta gtc atg 144 Ala Leu Pro Val Thr Ser Cys Glu Ala Gln Leu Cys Ser Val Val Met 35 40 45 ttt ggg acg tct gaa tgc ttc cta ctg gcg acc atg gcc tat gat cgc 192 Phe Gly Thr Ser Glu Cys Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg 50 55 60 tat gtg gcc atc tgc tca ccc ctg gtg aac tcc acc cac ttg tcc ccc 240 Tyr Val Ala Ile Cys Ser Pro Leu Val Asn Ser Thr His Leu Ser Pro 65 70 75 80 ata atc tgc ata ctc tta gtg ggg gtt tgc tac ctg ggt gga tgt gtg 288 Ile Ile Cys Ile Leu Leu Val Gly Val Cys Tyr Leu Gly Gly Cys Val 85 90 95 aat gcc tca aca ttt act agt tgt tta ttg agt ctg tct ttc tgt gga 336 Asn Ala Ser Thr Phe Thr Ser Cys Leu Leu Ser Leu Ser Phe Cys Gly 100 105 110 cca aat cag ata gat cat ttt ttc tgt gat ttc tct cct ttg ttg aaa 384 Pro Asn Gln Ile Asp His Phe Phe Cys Asp Phe Ser Pro Leu Leu Lys 115 120 125 ctt tcc tgc tca aat atc tcc att cct gaa att atc cct tcc atc tct 432 Leu Ser Cys Ser Asn Ile Ser Ile Pro Glu Ile Ile Pro Ser Ile Ser 130 135 140 tct gga tct atc att gtg gtc aca gta ttt gcc ata gcc atc tcc tac 480 Ser Gly Ser Ile Ile Val Val Thr Val Phe Ala Ile Ala Ile Ser Tyr 145 150 155 160 atc tac atc ctc atc acc atc ctg aag atg cgc tcc gcc gag ggg cgc 528 Ile Tyr Ile Leu Ile Thr Ile Leu Lys Met Arg Ser Ala Glu Gly Arg 165 170 175 cac aag gcc ttc tcc acc tgt acc tcc cac ctc gct gcg gtt act ctc 576 His Lys Ala Phe Ser Thr Cys Thr Ser His Leu Ala Ala Val Thr Leu 180 185 190 tac tat gga acg att acc ttc att tat gtg atg ccc aaa tcc agt tac 624 Tyr Tyr Gly Thr Ile Thr Phe Ile Tyr Val Met Pro Lys Ser Ser Tyr 195 200 205 tca act agc cag aac aga ttg ata tcg ctg tcc tac aca gtg gta atc 672 Ser Thr Ser Gln Asn Arg Leu Ile Ser Leu Ser Tyr Thr Val Val Ile 210 215 220 ccc ata ctg aac ccc ttt atc tat agt ctg agg aac aga gat gta aag 720 Pro Ile Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn Arg Asp Val Lys 225 230 235 240 gag gca cta aga aag gca act gtc aga ata tat tct tag 759 Glu Ala Leu Arg Lys Ala Thr Val Arg Ile Tyr Ser 245 250 <210> 324 <211> 252 <212> PRT <213> Homo sapiens <400> 324 Met Tyr Leu Phe Leu Ser His Leu Ala Phe Val Asp Ile Gly Leu Ala 1 5 10 15 Thr Val Val Thr Pro Ile Met Leu Met Gly Phe Leu Arg Arg Gly Thr 20 25 30 Ala Leu Pro Val Thr Ser Cys Glu Ala Gln Leu Cys Ser Val Val Met 35 40 45 Phe Gly Thr Ser Glu Cys Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg 50 55 60 Tyr Val Ala Ile Cys Ser Pro Leu Val Asn Ser Thr His Leu Ser Pro 65 70 75 80 Ile Ile Cys Ile Leu Leu Val Gly Val Cys Tyr Leu Gly Gly Cys Val 85 90 95 Asn Ala Ser Thr Phe Thr Ser Cys Leu Leu Ser Leu Ser Phe Cys Gly 100 105 110 Pro Asn Gln Ile Asp His Phe Phe Cys Asp Phe Ser Pro Leu Leu Lys 115 120 125 Leu Ser Cys Ser Asn Ile Ser Ile Pro Glu Ile Ile Pro Ser Ile Ser 130 135 140 Ser Gly Ser Ile Ile Val Val Thr Val Phe Ala Ile Ala Ile Ser Tyr 145 150 155 160 Ile Tyr Ile Leu Ile Thr Ile Leu Lys Met Arg Ser Ala Glu Gly Arg 165 170 175 His Lys Ala Phe Ser Thr Cys Thr Ser His Leu Ala Ala Val Thr Leu 180 185 190 Tyr Tyr Gly Thr Ile Thr Phe Ile Tyr Val Met Pro Lys Ser Ser Tyr 195 200 205 Ser Thr Ser Gln Asn Arg Leu Ile Ser Leu Ser Tyr Thr Val Val Ile 210 215 220 Pro Ile Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn Arg Asp Val Lys 225 230 235 240 Glu Ala Leu Arg Lys Ala Thr Val Arg Ile Tyr Ser 245 250 <210> 325 <211> 969 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(969) <400> 325 atg aat tcc ctg aag gac ggg aat cac acc gct ctg acg ggg ttc atc 48 Met Asn Ser Leu Lys Asp Gly Asn His Thr Ala Leu Thr Gly Phe Ile 1 5 10 15 cta ttg ggc tta aca gat gat cca atc ctt cga gtc atc ctc ttc atg 96 Leu Leu Gly Leu Thr Asp Asp Pro Ile Leu Arg Val Ile Leu Phe Met 20 25 30 atc atc cta tct ggt aat ctc agc ata att att ctt atc aga att tct 144 Ile Ile Leu Ser Gly Asn Leu Ser Ile Ile Ile Leu Ile Arg Ile Ser 35 40 45 tct cag ctc cat cat cct atg tat ttc ttt ctg agc cac ttg gct ttt 192 Ser Gln Leu His His Pro Met Tyr Phe Phe Leu Ser His Leu Ala Phe 50 55 60 gct gac atg gcc tat tca tct tct gtc aca ccc aac atg ctt gta aac 240 Ala Asp Met Ala Tyr Ser Ser Ser Val Thr Pro Asn Met Leu Val Asn 65 70 75 80 ttc ctg gtg gag aga aat aca gtc tcc tac ctt gga tgt gcc atc cag 288 Phe Leu Val Glu Arg Asn Thr Val Ser Tyr Leu Gly Cys Ala Ile Gln 85 90 95 ctt ggt tca gcg gct ttc ttt gca aca gtc gaa tgc gtc ctt ctg gct 336 Leu Gly Ser Ala Ala Phe Phe Ala Thr Val Glu Cys Val Leu Leu Ala 100 105 110 gcc atg gcc tat gac cgc ttt gtg gca att tgc agt cca ctg ctt tat 384 Ala Met Ala Tyr Asp Arg Phe Val Ala Ile Cys Ser Pro Leu Leu Tyr 115 120 125 tca acc aaa atg tcc aca caa gtc agt gtc cag cta ctc tta gta gtt 432 Ser Thr Lys Met Ser Thr Gln Val Ser Val Gln Leu Leu Leu Val Val 130 135 140 tac ata gct ggt ttt ctc att gct gtc tcc tat act act tcc ttc tat 480 Tyr Ile Ala Gly Phe Leu Ile Ala Val Ser Tyr Thr Thr Ser Phe Tyr 145 150 155 160 ttt tta ctc ttc tgt gga cca aat caa gtc aat cat ttt ttc tgt gat 528 Phe Leu Leu Phe Cys Gly Pro Asn Gln Val Asn His Phe Phe Cys Asp 165 170 175 ttc gct ccc tta ctt gaa ctc tcc tgt tct gat atc agt gtc tcc aca 576 Phe Ala Pro Leu Leu Glu Leu Ser Cys Ser Asp Ile Ser Val Ser Thr 180 185 190 g tt gtt ctc tca ttt tct tct gga tcc atc att gtg gtc act gtg tgt 624 Val Val Leu Ser Phe Ser Ser Gly Ser Ile Ile Val Val Thr Val Cys 195 200 205 gtc ata gcc gtc tgc tac atc tat atc ctc atc acc atc ctg aag atg 672 Val Ile Ala Val Cys Tyr Ile Tyr Ile Leu Ile Thr Ile Leu Lys Met 210 215 220 cgc tcc act gag ggg cac cac aag gcc ttc tcc acc tgc act tcc cac 720 Arg Ser Thr Glu Gly His His Lys Ala Phe Ser Thr Cys Thr Ser His 225 230 235 240 ctc act gtg gtt acc ctg ttc tat ggg acc att acc ttc att tat gtg 768 Leu Thr Val Val Thr Leu Phe Tyr Gly Thr Ile Thr Phe Ile Tyr Val 245 250 255 atg ccc aat ttt agc tac tca act gac cag aac aag gtg gtg tct gtg 816 Met Pro Asn Phe Ser Tyr Ser Thr Asp Gln Asn Lys Val Val Ser Val 260 265 270 ttg tac aca gtg gtg att ccc atg ttg aac ccc ctg atc tac agc ctc 864 Leu Tyr Thr Val Val Ile Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu 275 280 285 agg aac aag gag att aag ggg gct ctg aag aga gag ctt gtt aga aaa 912 Arg Asn Lys Glu Ile Lys Gly Ala Leu Lys Arg Glu Leu Val Arg Lys 290 295 300 ata ctt tct cat gat gct tgt tat ttt agt aga act tca aat aat gat 960 Ile Leu Ser His Asp Ala Cys Tyr Phe Ser Arg Thr Ser Asn Asn Asp 305 310 315 320 att aca tag 969 Ile Thr <210> 326 <211> 322 <212> PRT <213> Homo sapiens <400> 326 Met Asn Ser Leu Lys Asp Gly Asn His Thr Ala Leu Thr Gly Phe Ile 1 5 10 15 Leu Leu Gly Leu Thr Asp Asp Pro Ile Leu Arg Val Ile Leu Phe Met 20 25 30 Ile Ile Leu Ser Gly Asn Leu Ser Ile Ile Ile Leu Ile Arg Ile Ser 35 40 45 Ser Gln Leu His His Pro Met Tyr Phe Phe Leu Ser His Leu Ala Phe 50 55 60 Ala Asp Met Ala Tyr Ser Ser Ser Val Thr Pro Asn Met Leu Val Asn 65 70 75 80 Phe Leu Val Glu Arg Asn Thr Val Ser Tyr Leu Gly Cys Ala Ile Gln 85 90 95 Leu Gly Ser Ala Ala Phe Phe Ala Thr Val Glu Cys Val Leu Leu Ala 100 105 110 Ala Met Ala Tyr Asp Arg Phe Val Ala Ile Cys Ser Pro Leu Leu Tyr 115 120 125 Ser Thr Lys Met Ser Thr Gln Val Ser Val Gln Leu Leu Leu Val Val 130 135 140 Tyr Ile Ala Gly Phe Leu Ile Ala Val Ser Tyr Thr Thr Ser Phe Tyr 145 150 155 160 Phe Leu Leu Phe Cys Gly Pro Asn Gln Val Asn His Phe Phe Cys Asp 165 170 175 Phe Ala Pro Leu Leu Glu Leu Ser Cys Ser Asp Ile Ser Val Ser Thr 180 185 190 Val Val Leu Ser Phe Ser Ser Gly Ser Ile Ile Val Val Thr Val Cys 195 200 205 Val Ile Ala Val Cys Tyr Ile Tyr Ile Leu Ile Thr Ile Leu Lys Met 210 215 220 Arg Ser Thr Glu Gly His His Lys Ala Phe Ser Thr Cys Thr Ser His 225 230 235 240 Leu Thr Val Val Thr Leu Phe Tyr Gly Thr Ile Thr Phe Ile Tyr Val 245 250 255 Met Pro Asn Phe Ser Tyr Ser Thr Asp Gln Asn Lys Val Val Ser Val 260 265 270 Leu Tyr Thr Val Val Ile Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu 275 280 285 Arg Asn Lys Glu Ile Lys Gly Ala Leu Lys Arg Glu Leu Val Arg Lys 290 295 300 Ile Leu Ser His Asp Ala Cys Tyr Phe Ser Arg Thr Ser Asn Asn Asp 305 310 315 320 Ile Thr <210> 327 <211> 942 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(942) <400> 327 atg gct ggg gaa aac cat act aca ctg cct gaa ttc ctc ctt ctg gga 48 Met Ala Gly Glu Asn His Thr Thr Leu Pro Glu Phe Leu Leu Leu Gly 1 5 10 15 ttc tct gac ctc aag gcc ctg cag ggc ccc ctg ttc tgg gtg gtg ctt 96 Phe Ser Asp Leu Lys Ala Leu Gln Gly Pro Leu Phe Trp Val Val Leu 20 25 30 ctg gtc tac ctg gtc acc ttg ctg ggt aac tcc ctg atc atc ctc ctc 144 Leu Val Tyr Leu Val Thr Leu Leu Gly Asn Ser Leu Ile Ile Leu Leu 35 40 45 aca cag gtc agc cct gcc ctg cac tcc ccc atg tac ttc ttc ctg cgc 192 Thr Gln Val Ser Pro Ala Leu His Ser Pro Met Tyr Phe Phe Leu Arg 50 55 60 caa ctc tca gtg gtg gag ctc ttc tac acc act gac atc gtg ccc agg 240 Gln Leu Ser Val Val Glu Leu Phe Tyr Thr Thr Asp Ile Val Pro Arg 65 70 75 80 acc ctg gcc aat ctg ggc tcc ccg cat ccc cag gcc atc tct ttc cag 288 Thr Leu Ala Asn Leu Gly Ser Pro His Pro Gln Ala Ile Ser Phe Gln 85 90 95 ggc tgt gca gcc cag atg tac gtc ttc att gtc ctg ggc atc tcg gag 336 Gly Cys Ala Ala Gln Met Tyr Val Phe Ile Val Leu Gly Ile Ser Glu 100 105 110 tgc tgc ctg ctc acg gcc atg gcc tat gac cga tat gtt gcc atc tgc 384 Cys Cys Leu Leu Thr Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys 115 120 125 cag ccc cta cgc tat tcc acc ctc ttg agc cca cgg gcc tgc ttg gcc 432 Gln Pro Leu Arg Tyr Ser Thr Leu Leu Ser Pro Arg Ala Cys Leu Ala 130 135 140 atg gtg ggg tcc tcc tgg ctc aca ggc atc atc acg gcc acc acc cat 480 Met Val Gly Ser Ser Trp Leu Thr Gly Ile Ile Thr Ala Thr Thr His 145 150 155 160 gcc tcc ctc atc ttc tct cta cct ttt cgc agc cac ccg atc atc ccg 528 Ala Ser Leu Ile Phe Ser Leu Pro Phe Arg Ser His Pro Ile Ile Pro 165 170 175 cac ttt ctc tgt gac atc ctg cca gta ctg agg ctg gca agt gct ggg 576 His Phe Leu Cys Asp Ile Leu Pro Val Leu Arg Leu Ala Ser Ala Gly 180 185 190 aag cac agg agc gag atc tcc gtg atg aca gcc acc ata gtc ttc att 624 Lys His Arg Ser Glu Ile Ser Val Met Thr Ala Thr Ile Val Phe Ile 195 200 205 atg atc ccc ttc tct ctg att gtc acc tct tac atc cgc atc ctg ggt 672 Met Ile Pro Phe Ser Leu Ile Val Thr Ser Tyr Ile Arg Ile Leu Gly 210 215 220 gcc atc cta gca atg gcc tcc acc cag agc cgc cgc aag gtc ttc tcc 720 Ala Ile Leu Ala Met Ala Ser Thr Gln Ser Arg Arg Lys Val Phe Ser 225 230 235 240 acc tgc tcc tcc cat ctg ctc gtg gtc tct ctc ttc ttt gga aca gcc 768 Thr Cys Ser Ser His Leu Leu Val Val Ser Leu Phe Phe Gly Thr Ala 245 250 255 agc atc acc tac atc cgg ccg cag gca ggc tcc tct gtt acc aca gac 816 Ser Ile Thr Tyr Ile Arg Pro Gln Ala Gly Ser Ser Val Thr Thr Asp 260 265 270 cgc gtc ctc agt ctc ttc tac aca gtc atc aca ccc atg ctc aac ccc 864 Arg Val Leu Ser Leu Phe Tyr Thr Val Ile Thr Pro Met Leu Asn Pro 275 280 285 atc atc tac acc ctt cgg aac aag gac gtg agg agg gcc ctg cga cac 912 Ile Ile Tyr Thr Leu Arg Asn Lys Asp Val Arg Arg Ala Leu Arg His 290 295 300 ttg gtg aag agg cag cgc ccc tca ccc tga 942 Leu Val Lys Arg Gln Arg Pro Ser Pro 305 310 <210> 328 <211> 313 <212> PRT <213> Homo sapiens <400> 328 Met Ala Gly Glu Asn His Thr Thr Leu Pro Glu Phe Leu Leu Leu Gly 1 5 10 15 Phe Ser Asp Leu Lys Ala Leu Gln Gly Pro Leu Phe Trp Val Val Leu 20 25 30 Leu Val Tyr Leu Val Thr Leu Leu Gly Asn Ser Leu Ile Ile Leu Leu 35 40 45 Thr Gln Val Ser Pro Ala Leu His Ser Pro Met Tyr Phe Phe Leu Arg 50 55 60 Gln Leu Ser Val Val Glu Leu Phe Tyr Thr Thr Asp Ile Val Pro Arg 65 70 75 80 Thr Leu Ala Asn Leu Gly Ser Pro His Pro Gln Ala Ile Ser Phe Gln 85 90 95 Gly Cys Ala Ala Gln Met Tyr Val Phe Ile Val Leu Gly Ile Ser Glu 100 105 110 Cys Cys Leu Leu Thr Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys 115 120 125 Gln Pro Leu Arg Tyr Ser Thr Leu Leu Ser Pro Arg Ala Cys Leu Ala 130 135 140 Met Val Gly Ser Ser Trp Leu Thr Gly Ile Ile Thr Ala Thr Thr His 145 150 155 160 Ala Ser Leu Ile Phe Ser Leu Pro Phe Arg Ser His Pro Ile Ile Pro 165 170 175 His Phe Leu Cys Asp Ile Leu Pro Val Leu Arg Leu Ala Ser Ala Gly 180 185 190 Lys His Arg Ser Glu Ile Ser Val Met Thr Ala Thr Ile Val Phe Ile 195 200 205 Met Ile Pro Phe Ser Leu Ile Val Thr Ser Tyr Ile Arg Ile Leu Gly 210 215 220 Ala Ile Leu Ala Met Ala Ser Thr Gln Ser Arg Arg Lys Val Phe Ser 225 230 235 240 Thr Cys Ser Ser His Leu Leu Val Val Ser Leu Phe Phe Gly Thr Ala 245 250 255 Ser Ile Thr Tyr Ile Arg Pro Gln Ala Gly Ser Ser Val Thr Thr Asp 260 265 270 Arg Val Leu Ser Leu Phe Tyr Thr Val Ile Thr Pro Met Leu Asn Pro 275 280 285 Ile Ile Tyr Thr Leu Arg Asn Lys Asp Val Arg Arg Ala Leu Arg His 290 295 300 Leu Val Lys Arg Gln Arg Pro Ser Pro 305 310 <210> 329 <211> 939 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(939) <400> 329 atg gag cgg gtc aat gag act gtg gtg aga gag gtc atc ttc ctc ggc 48 Met Glu Arg Val Asn Glu Thr Val Val Arg Glu Val Ile Phe Leu Gly 1 5 10 15 ttc tca tcc ctg gcc agg ctg cag cag ctg ctc ttt gtt atc ttc ctg 96 Phe Ser Ser Leu Ala Arg Leu Gln Gln Leu Leu Phe Val Ile Phe Leu 20 25 30 ctc ctc tac ctg ttc act ctg ggc acc aat gca atc atc att tcc acc 144 Leu Leu Tyr Leu Phe Thr Leu Gly Thr Asn Ala Ile Ile Ile Ser Thr 35 40 45 att gtc ctg gac agg gcc ctt cat atc ccc atg tac ttc ttc ctt gcc 192 Ile Val Leu Asp Arg Ala Leu His Ile Pro Met Tyr Phe Phe Leu Ala 50 55 60 atc ctc tct tgc tct gag att tgc tac acc ttc atc att gta ccc aag 240 Ile Leu Ser Cys Ser Glu Ile Cys Tyr Thr Phe Ile Ile Val Pro Lys 65 70 75 80 atg ctg gtt gac ctg ctg tcc cag aag aag acc att tct ttc ctg ggc 288 Met Leu Val Asp Leu Leu Ser Gln Lys Lys Thr Ile Ser Phe Leu Gly 85 90 95 tgt gcc atc caa atg ttt tcc ttc ctc ttc ctt ggc tgc tct cac tcc 336 Cys Ala Ile Gln Met Phe Ser Phe Leu Phe Leu Gly Cys Ser His Ser 100 105 110 ttt ctg ctg gca gtc atg ggt tat gat cgt tac ata gcc atc tgt aac 384 Phe Leu Leu Ala Val Met Gly Tyr Asp Arg Tyr Ile Ala Ile Cys Asn 115 120 125 cca ctg cgc tac tca gtg cta atg gga cat ggg gtg tgt atg gga cta 432 Pro Leu Arg Tyr Ser Val Leu Met Gly His Gly Val Cys Met Gly Leu 130 135 140 gtg gct gct gcc tgt gcc tgt ggc ttc act gtt gca cag atc atc aca 480 Val Ala Ala Ala Cys Ala Cys Gly Phe Thr Val Ala Gln Ile Ile Thr 145 150 155 160 tcc ttg gta ttt cac ctg cct ttt tat tcc tcc aat caa cta cat cac 528 Ser Leu Val Phe His Leu Pro Phe Tyr Ser Ser Asn Gln Leu His His 165 170 175 ttc ttc tgt gac att gct cct gtc ctc aag ctg gca tct cac cat aac 576 Phe Phe Cys Asp Ile Ala Pro Val Leu Lys Leu Ala Ser His His Asn 180 185 190 cac ttt agt cag att gtc atc ttc atg ctc tgt aca ttg gtc ctg gct 624 His Phe Ser Gln Ile Val Ile Phe Met Leu Cys Thr Leu Val Leu Ala 195 200 205 atc ccc tta ttg ttg atc ttg gtg tcc tat gtt cac atc ctc tct gcc 672 Ile Pro Leu Leu Leu Ile Leu Val Ser Tyr Val His Ile Leu Ser Ala 210 215 220 ata ctt cag ttt cct tcc aca ctg ggt agg tgc aaa gct ttt tct acc 720 Ile Leu Gln Phe Pro Ser Thr Leu Gly Arg Cys Lys Ala Phe Ser Thr 225 230 235 240 tgt gta tct cac ctc att att gtc act gtc cac tat ggc tgt gcc tcc 768 Cys Val Ser His Leu Ile Ile Val Thr Val His Tyr Gly Cys Ala Ser 245 250 255 ttt atc tac tta agg cct cag tcc aac tac tcc tca agc cag gat gct 816 Phe Ile Tyr Leu Arg Pro Gln Ser Asn Tyr Ser Ser Ser Gln Asp Ala 260 265 270 cta ata tca gta tcc tac act att ata act cca ttg ttc aac cca atg 864 Leu Ile Ser Val Ser Tyr Thr Ile Ile Thr Pro Leu Phe Asn Pro Met 275 280 285 att tat agc ttg aga aat aaa gag ttc aaa tca gct ctt tgt aaa att 912 Ile Tyr Ser Leu Arg Asn Lys Glu Phe Lys Ser Ala Leu Cys Lys Ile 290 295 300 gtg aga aga aca att tcc ctg ttg taa 939 Val Arg Arg Thr Ile Ser Leu Leu 305 310 <2 10> 330 <211> 312 <212> PRT <213> Homo sapiens <400> 330 Met Glu Arg Val Asn Glu Thr Val Val Arg Glu Val Ile Phe Leu Gly 1 5 10 15 Phe Ser Ser Leu Ala Arg Leu Gln Gln Leu Leu Phe Val Ile Phe Leu 20 25 30 Leu Leu Tyr Leu Phe Thr Leu Gly Thr Asn Ala Ile Ile Ile Ser Thr 35 40 45 Ile Val Leu Asp Arg Ala Leu His Ile Pro Met Tyr Phe Phe Leu Ala 50 55 60 Ile Leu Ser Cys Ser Glu Ile Cys Tyr Thr Phe Ile Ile Val Pro Lys 65 70 75 80 Met Leu Val Asp Leu Leu Ser Gln Lys Lys Thr Ile Ser Phe Leu Gly 85 90 95 Cys Ala Ile Gln Met Phe Ser Phe Leu Phe Leu Gly Cys Ser His Ser 100 105 110 Phe Leu Leu Ala Val Met Gly Tyr Asp Arg Tyr Ile Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Ser Val Leu Met Gly His Gly Val Cys Met Gly Leu 130 135 140 Val Ala Ala Ala Cys Ala Cys Gly Phe Thr Val Ala Gln Ile Ile Thr 145 150 155 160 Ser Leu Val Phe His Leu Pro Phe Tyr Ser Ser Asn Gln Leu His His 165 170 175 Phe Phe Cys Asp Ile Ala Pro Val Leu Lys Leu Ala Ser His His Asn 180 185 190 His Phe Ser Gln Ile Val Ile Phe Met Leu Cys Thr Leu Val Leu Ala 195 200 205 Ile Pro Leu Leu Leu Ile Leu Val Ser Tyr Val His Ile Leu Ser Ala 210 215 220 Ile Leu Gln Phe Pro Ser Thr Leu Gly Arg Cys Lys Ala Phe Ser Thr 225 230 235 240 Cy s Val Ser His Leu Ile Ile Val Thr Val His Tyr Gly Cys Ala Ser 245 250 255 Phe Ile Tyr Leu Arg Pro Gln Ser Asn Tyr Ser Ser Ser Gln Asp Ala 260 265 270 Leu Ile Ser Val Ser Tyr Thr Ile Ile Thr Pro Leu Phe Asn Pro Met 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Phe Lys Ser Ala Leu Cys Lys Ile 290 295 300 Val Arg Arg Thr Ile Ser Leu Leu 305 310 <210> 331 <211> 1008 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1008) <400> 331 atg ccc caa att ctt ata ttc aca tac ctg aat atg ttt tac ttc ttt 48 Met Pro Gln Ile Leu Ile Phe Thr Tyr Leu Asn Met Phe Tyr Phe Phe 1 5 10 15 ccc cct ttg cag atc ttg gca gaa aac ctc acc atg gtc acc gaa ttc 96 Pro Pro Leu Gln Ile Leu Ala Glu Asn Leu Thr Met Val Thr Glu Phe 20 25 30 ctg ttg ctg ggt ttt tcc agc ctt ggt gaa att cag ctg gcc ctc ttt 144 Leu Leu Leu Gly Phe Ser Ser Leu Gly Glu Ile Gln Leu Ala Leu Phe 35 40 45 gta gtt ttt ctt ttt ctg tat cta gtc att ctt agt ggc aat gtc acc 192 Val Val Phe Leu Phe Leu Tyr Leu Val Ile Leu Ser Gly Asn Val Thr 50 55 60 att atc agt gtc atc cac ctg gat aaa agc ctc cac aca cca atg tac 240 Ile Ile Ser Val Ile His Leu Asp Lys Ser Leu His Thr Pro Met Tyr 65 70 75 80 ttc ttc ctt ggc att ctc tca aca tct gag acc ttc tac acc ttt gtc 288 Phe Phe Leu Gly Ile Leu Ser Thr Ser Glu Thr Phe Tyr Thr Phe Val 85 90 95 att cta ccc aag atg ctc atc aat cta ctt tct gtg gcc agg aca atc 336 Ile Leu Pro Lys Met Leu Ile Asn Leu Leu Ser Val Ala Arg Thr Ile 100 105 110 tcc ttc aac tgt tgt gct ctt caa atg ttc ttc ttc ctt ggt ttt gcc 384 Ser Phe Asn Cys Cys Ala Leu Gln Met Phe Phe Phe Leu Gly Phe Ala 115 120 125 att acc aac tgc ctg cta ttg ggt gtg atg ggt tat gat cgc tat gct 432 Ile Thr Asn Cys Leu Leu Leu Gly Val Met Gly Tyr Asp Arg Tyr Ala 130 135 140 gcc att tgt cac cct ctg cat tac ccc act ctt atg agc tgg cag gtg 480 Ala Ile Cys His Pro Leu His Tyr Pro Thr Leu Met Ser Trp Gln Val 145 150 155 160 tgt gga aaa ctg gca gct gcc tgt gca att ggt ggc ttc ttg gcc tct 528 Cys Gly Lys Leu Ala Ala Ala Cys Ala Ile Gly Gly Phe Leu Ala Ser 165 170 175 ctt aca gta gta aat tta gtt ttc agc ctc cct ttt tgt agc gcc aac 576 Leu Thr Val Val Asn Leu Val Phe Ser Leu Pro Phe Cys Ser Ala Asn 180 185 190 aaa gtc aat cat tac ttc tgt gac atc tca gca gtc att ctt ctg gct 624 Lys Val Asn His Tyr Phe Cys Asp Ile Ser Ala Val Ile Leu Leu Ala 195 200 205 tgt acc aac aca gat gtt aac gaa ttt gtg ata ttc att tgt gga gtt 672 Cys Thr Asn Thr Asp Val Asn Glu Phe Val Ile Phe Ile Cys Gly Val 210 215 220 ctt gta ctt gtg gtt ccc ttt ctg ttt atc tgt gtt tct tat ctc tgc 720 Leu Val Leu Val Val Pro Phe Leu Phe Ile Cys Val Ser Tyr Leu Cys 225 230 235 240 att ctg agg act atc ctg aag att ccc tca gct gag ggc aga cgg aaa 768 Ile Leu Arg Thr Ile Leu Lys Ile Pro Ser Ala Glu Gly Arg Arg Lys 245 250 255 gcg ttt tcc acc tgc gcc tct cac ctc agt gtt gtt att gtt cat tat 816 Ala Phe Ser Thr Cys Ala Ser His Leu Ser Val Val Ile Val His Tyr 260 265 270 ggc tgt gct tcc ttc atc tac ctg agg cct aca gca aac tat gtg tcc 864 Gly Cys Ala Ser Phe Ile Tyr Leu Arg Pro Thr Ala Asn Tyr Val Ser 275 280 285 aac aaa gac agg ctg gtg acg gtg aca tac acg att gtc act cca tta 912 Asn Lys Asp Arg Leu Val Thr Val Thr Tyr Thr Ile Val Thr Pro Leu 290 295 300 cta aac ccc atg gtt tat agc ctc aga aac aag gat gtc caa ctt gct 960 Leu Asn Pro Met Val Tyr Ser Leu Arg Asn Lys Asp Val Gln Leu Ala 305 310 315 320 atc aga aaa gtg ttg ggc aag aaa ggt tct cta aaa cta tat aat tga 1008 Ile Arg Lys Val Leu Gly Lys Lys Gly Ser Leu Lys Leu Tyr Asn 325 330 335 <210> 332 <211> 335 <212> PRT <213> Homo sapiens <400> 332 Met Pro Gln Ile Leu Ile Phe Thr Tyr Leu Asn Met Phe Tyr Phe Phe 1 5 10 15 Pro Pro Leu Gln Ile Leu Ala Glu Asn Leu Thr Met Val Thr Glu Phe 20 25 30 Leu Leu Leu Gly Phe Ser Ser Leu Gly Glu Ile Gln Leu Ala Leu Phe 35 40 45 Val Val Phe Leu Phe Leu Tyr Leu Val Ile Leu Ser Gly Asn Val Thr 50 55 60 Ile Ile Ser Val Ile His Leu Asp Lys Ser Leu His Thr Pro Met Tyr 65 70 75 80 Phe Phe Leu Gly Ile Leu Ser Thr Ser Glu Thr Phe Tyr Thr Phe Val 85 90 95 Ile Leu Pro Lys Met Leu Ile Asn Leu Leu Ser Val Ala Arg Thr Ile 100 105 110 Ser Phe Asn Cys Cys Ala Leu Gln Met Phe Phe Phe Leu Gly Phe Ala 115 120 125 Ile Thr Asn Cys Leu Leu Leu Gly Val Met Gly Tyr Asp Arg Tyr Ala 130 135 140 Ala Ile Cys His Pro Leu His Tyr Pro Thr Leu Met Ser Trp Gln Val 145 150 155 160 Cys Gly Lys Leu Ala Ala Ala Cys Ala Ile Gly Gly Phe Leu Ala Ser 165 170 175 Leu Thr Val Val Asn Leu Val Phe Ser Leu Pro Phe Cys Ser Ala Asn 180 185 190 Lys Val Asn His Tyr Phe Cys Asp Ile Ser Ala Val Ile Leu Leu Ala 195 200 205 Cys Thr Asn Thr Asp Val Asn Glu Phe Val Ile Phe Ile Cys Gly Val 210 215 220 Leu Val Leu Val Val Pro Phe Leu Phe Ile Cys Val Ser Tyr Leu Cys 225 230 235 240 Ile Leu Arg Thr Ile Leu Lys Ile Pro Ser Ala Glu Gly Arg Arg Lys 245 250 255 Ala Phe Ser Thr Cys Ala Ser His Leu Ser Val Val Ile Val His Tyr 260 265 270 Gly Cys Ala Ser Phe Ile Tyr Leu Arg Pro Thr Ala Asn Tyr Val Ser 275 280 285 Asn Lys Asp Arg Leu Val Thr Val Thr Tyr Thr Ile Val Thr Pro Leu 290 295 300 Leu Asn Pro Met Val Tyr Ser Leu Arg Asn Lys Asp Val Gln Leu Ala 305 310 315 320 Ile Arg Lys Val Leu Gly Lys Lys Gly Ser Leu Lys Leu Tyr Asn 325 330 335 <210> 333 <211> 978 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(978) <400> 333 atg acc acc ata att ctg gaa gta gat aat cat aca gtg aca aca cgt 48 Met Thr Thr Ile Ile Leu Glu Val Asp Asn His Thr Val Thr Thr Arg 1 5 10 15 ttc att ctt ctg ggg ttt cca aca cga cca gcc ttc cag ctt ctc ttt 96 Phe Ile Leu Leu Gly Phe Pro Thr Arg Pro Ala Phe Gln Leu Leu Phe 20 25 30 ttc tcc att ttc ctg gca acc tat ctg ctg aca ctg ctg gag aat ctt 144 Phe Ser Ile Phe Leu Ala Thr Tyr Leu Leu Thr Leu Leu Glu Asn Leu 35 40 45 ctt atc atc tta gct atc cac agt gat ggg cag ctg cat aag ccc atg 192 Leu Ile Ile Leu Ala Ile His Ser Asp Gly Gln Leu His Lys Pro Met 50 55 60 tac ttc ttc ttg agc cac ctc tcc ttc ctg gag atg tgg tat gtc aca 240 Tyr Phe Phe Leu Ser His Leu Ser Phe Leu Glu Met Trp Tyr Val Thr 65 70 75 80 gtc atc agc ccc aag atg ctt gtt gac ttc ctc agt cat gac aag agt 288 Val Ile Ser Pro Lys Met Leu Val Asp Phe Leu Ser His Asp Lys Ser 85 90 95 att tcc ttc aat ggc tgc atg act caa ctt tac ttt ttt gtg acc ttt 336 Ile Ser Phe Asn Gly Cys Met Thr Gln Leu Tyr Phe Phe Val Thr Phe 100 105 110 gtc tgc act gag tac atc ctt ctt gct atc atg gcc ttt gac cgc tat 384 Val Cys Thr Glu Tyr Ile Leu Leu Ala Ile Met Ala Phe Asp Arg Tyr 115 120 125 gta gcc att tgt aat cca cta cgc tac cca gtc atc atg acc aac cag 432 Val Ala Ile Cys Asn Pro Leu Arg Tyr Pro Val Ile Met Thr Asn Gln 130 135 140 ctc tgt ggc aca ctg gct gga gga tgc tgg ttc tgt gga ctc atg act 480 Leu Cys Gly Thr Leu Ala Gly Gly Cys Trp Phe Cys Gly Leu Met Thr 145 150 155 160 gcc atg att aag atg gtt ttt ata gca caa ctt cac tac tgt ggc atg 528 Ala Met Ile Lys Met Val Phe Ile Ala Gln Leu His Tyr Cys Gly Met 165 170 175 cct cag atc aat cac tac ttt tgt gat atc tct cca ctc ctt aac gtc 576 Pro Gln Ile Asn His Tyr Phe Cys Asp Ile Ser Pro Leu Leu Asn Val 180 185 190 tcc tgt gag gat gcc tca cag gct gag atg gtg gac ttc ttc ttg gcc 624 Ser Cys Glu Asp Ala Ser Gln Ala Glu Met Val Asp Phe Phe Leu Ala 195 200 205 ctc atg gtc att gct att cct ctt tgt gtt gtg gtg gca tcc tac gct 672 Leu Met Val Ile Ala Ile Pro Leu Cys Val Val Val Ala Ser Tyr Ala 210 215 220 gct atc ctt gcc acc atc ctc agg atc cct tct gct cag ggc cgc caa 720 Ala Ile Leu Ala Thr Ile Leu Arg Ile Pro Ser Ala Gln Gly Arg Gln 225 230 235 240 aag gca ttc tcc acc tgt gcc tcc cac ctg acc gtc gta att ctc ttc 768 Lys Ala Phe Ser Thr Cys Ala Ser His Leu Thr Val Val Ile Leu Phe 245 250 255 tat tcc atg aca ctt ttc acc tat gcc cgt ccc aaa ctc atg tat gcc 816 Tyr Ser Met Thr Leu Phe Thr Tyr Ala Arg Pro Lys Leu Met Tyr Ala 260 265 270 tac aat tcc aac aaa gtg gta tct gtt ctc tac act gtc att gtt cca 864 Tyr Asn Ser Asn Lys Val Val Ser Val Leu Tyr Thr Val Ile Val Pro 275 280 285 ctc ctc aac ccc atc att tac tgt ctg agg aac cat gaa gta aag gca 912 Leu Leu Asn Pro Ile Ile Tyr Cys Leu Arg Asn His Glu Val Lys Ala 290 295 300 gcc ctc aga aag acc ata cat tgc aga gga agt ggg ccc cag gga aat 960 Ala Leu Arg Lys Thr Ile His Cys Arg Gly Ser Gly Pro Gln Gly Asn 305 310 315 320 ggg gct ttc agt agt taa 978 Gly Ala Phe Ser Ser 325 <210> 334 <211> 325 <212> PRT <213> Homo sapiens <400> 334 Met Thr Thr Ile Ile Leu Glu Val Asp Asn His Thr Val Thr Thr Arg 1 5 10 15 Phe Ile Leu Leu Gly Phe Pro Thr Arg Pro Ala Phe Gln Leu Leu Phe 20 25 30 Phe Ser Ile Phe Leu Ala Thr Tyr Leu Leu Thr Leu Leu Glu Asn Leu 35 40 45 Leu Ile Ile Leu Ala Ile His Ser Asp Gly Gln Leu His Lys Pro Met 50 55 60 Tyr Phe Phe Leu Ser His Leu Ser Phe Leu Glu Met Trp Tyr Val Thr 65 70 75 80 Val Ile Ser Pro Lys Met Leu Val Asp Phe Leu Ser His Asp Lys Ser 85 90 95 Ile Ser Phe Asn Gly Cys Met Thr Gln Leu Tyr Phe Phe Val Thr Phe 100 105 110 Val Cys Thr Glu Tyr Ile Leu Leu Ala Ile Met Ala Phe Asp Arg Tyr 115 120 125 Val Ala Ile Cys Asn Pro Leu Arg Tyr Pro Val Ile Met Thr Asn Gln 130 135 140 Leu Cys Gly Thr Leu Ala Gly Gly Cys Trp Phe Cys Gly Leu Met Thr 145 150 155 160 Ala Met Ile Lys Met Val Phe Ile Ala Gln Leu His Tyr Cys Gly Met 165 170 175 Pro Gln Ile Asn His Tyr Phe Cys Asp Ile Ser Pro Leu Leu Asn Val 180 185 190 Ser Cys Glu Asp Ala Ser Gln Ala Glu Met Val Asp Phe Phe Leu Ala 195 200 205 Leu Met Val Ile Ala Ile Pro Leu Cys Val Val Val Ala Ser Tyr Ala 210 215 220 Ala Ile Leu Ala Thr Ile Leu Arg Ile Pro Ser Ala Gln Gly Arg Gln 225 230 235 240 Lys Ala Phe Ser Thr Cys Ala Ser His Leu Thr Val Val Ile Leu Phe 245 250 255 Tyr Ser Met Thr Leu Phe Thr Tyr Ala Arg Pro Lys Leu Met Tyr Ala 260 265 270 Tyr Asn Ser Asn Lys Val Val Ser Val Leu Tyr Thr Val Ile Val Pro 275 280 285 Leu Leu Asn Pro Ile Ile Tyr Cys Leu Arg Asn His Glu Val Lys Ala 290 295 300 Ala Leu Arg Lys Thr Ile His Cys Arg Gly Ser Gly Pro Gln Gly Asn 305 310 315 320 Gly Ala Phe Ser Ser 325 <210> 335 <211> 945 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(945) <400> 335 atg cga ggt ttc aac aaa acc act gtg gtt aca cag ttc atc ctg gtg 48 Met Arg Gly Phe Asn Lys Thr Thr Val Val Thr Gln Phe Ile Leu Val 1 5 10 15 ggt ttc tcc agc ctg ggg gag ctc cag ctg ctg ctt ttt gtc atc ttt 96 Gly Phe Ser Ser Leu Gly Glu Leu Gln Leu Leu Leu Phe Val Ile Phe 20 25 30 ctt ctc cta tac ttg aca atc ctg gtg gcc aat gtg acc atc atg gcc 144 Leu Leu Leu Tyr Leu Thr Ile Leu Val Ala Asn Val Thr Ile Met Ala 35 40 45 gtt att cgc ttc agc tgg act ctc cac act ccc atg tat ggc ttt cta 192 Val Ile Arg Phe Ser Trp Thr Leu His Thr Pro Met Tyr Gly Phe Leu 50 55 60 ttc atc ctt tca ttt tct gag tcc tgc tac act ttt gtc atc atc cct 240 Phe Ile Leu Ser Phe Ser Glu Ser Cys Tyr Thr Phe Val Ile Ile Pro 65 70 75 80 cag ctg ctg gtc cac ctg ctc tca gac acc aag acc atc tcc ttc atg 288 Gln Leu Leu Val His Leu Leu Ser Asp Thr Lys Thr Ile Ser Phe Met 85 90 95 gcc tgt gcc acc cag ctg ttc ttt ttc ctt ggc ttt gct tgc acc aac 336 Ala Cys Ala Thr Gln Leu Phe Phe Phe Leu Gly Phe Ala Cys Thr Asn 100 105 110 tgc ctc ctc att gct gtg atg gga tat gat cgc tat gta gca att tgt 384 Cys Leu Leu Ile Ala Val Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys 115 120 125 cac cct ctg agg tac aca ctc atc ata aac aaa agg ctg ggg ttg gag 432 His Pro Leu Arg Tyr Thr Leu Ile Ile Asn Lys Arg Leu Gly Leu Glu 130 135 140 ttg att tct ctc tca gga gcc aca ggt ttc ttt att gct ttg gtg gcc 480 Leu Ile Ser Leu Ser Gly Ala Thr Gly Phe Phe Ile Ala Leu Val Ala 145 150 155 160 acc aac ctc att tgt gac atg cgt ttt tgt ggc ccc aac agg gtt aac 528 Thr Asn Leu Ile Cys Asp Met Arg Phe Cys Gly Pro Asn Arg Val Asn 165 170 175 cac tat ttc tgt gac atg gca cct gtt atc aag tta gcc tgc act gac 576 His Tyr Phe Cys Asp Met Ala Pro Val Ile Lys Leu Ala Cys Thr Asp 180 185 190 acc cat gtg aaa gag ctg gct tta ttt agc ctc agc atc ctg gta att 624 Thr His Val Lys Glu Leu Ala Leu Phe Ser Leu Ser Ile Leu Val Ile 195 200 205 atg gtg cct ttt ctg tta att ctc ata tcc tat ggc ttc ata gtt aac 672 Met Val Pro Phe Leu Leu Ile Leu Ile Ser Tyr Gly Phe Ile Val Asn 210 215 220 acc atc ctg aag atc ccc tca gct gag ggc aag aag gcc ttt gtc acc 720 Thr Ile Leu Lys Ile Pro Ser Ala Glu Gly Lys Lys Ala Phe Val Thr 225 230 235 240 tgt gcc tca cat ctc act gtg gtc ttt gtc cac tat ggc tgt gcc tct 768 Cys Ala Ser His Leu Thr Val Val Phe Val His Tyr Gly Cys Ala Ser 245 250 255 atc atc tat ctg cgg ccc aag tcc aag tct gcc tca gac aag gat cag 816 Ile Ile Tyr Leu Arg Pro Lys Ser Lys Ser Ala Ser Asp Lys Asp Gln 260 265 270 ttg gtg gca gtg acc tac aca gtg gtt act ccc tta ctt aat cct ctt 864 Leu Val Ala Val Thr Tyr Thr Val Val Thr Pro Leu Leu Asn Pro Leu 275 280 285 gtc tac agt ctg agg aac aaa gag gta aaa act gca ttg aaa aga gtt 912 Val Tyr Ser Leu Arg Asn Lys Glu Val Lys Thr Ala Leu Lys Arg Val 290 295 300 ctt gga atg cct gtg gca acc aag atg agc taa 945 Leu Gly Met Pro Val Ala Thr Lys Met Ser 305 310 315 <210> 336 <211> 314 <212> PRT <213> Homo sapiens <400> 336 Met Arg Gly Phe Asn Lys Thr Thr Val Val Thr Gln Phe Ile Leu Val 1 5 10 15 Gly Phe Ser Ser Leu Gly Glu Leu Gln Leu Leu Leu Phe Val Ile Phe 20 25 30 Leu Leu Leu Tyr Leu Thr Ile Leu Val Ala Asn Val Thr Ile Met Ala 35 40 45 Val Ile Arg Phe Ser Trp Thr Leu His Thr Pro Met Tyr Gly Phe Leu 50 55 60 Phe Ile Leu Ser Phe Ser Glu Ser Cys Tyr Thr Phe Val Ile Ile Pro 65 70 75 80 Gln Leu Leu Val His Leu Leu Ser Asp Thr Lys Thr Ile Ser Phe Met 85 90 95 Ala Cys Ala Thr Gln Leu Phe Phe Phe Leu Gly Phe Ala Cys Thr Asn 100 105 110 Cys Leu Leu Ile Ala Val Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys 115 120 125 His Pro Leu Arg Tyr Thr Leu Ile Ile Asn Lys Arg Leu Gly Leu Glu 130 135 140 Leu Ile Ser Leu Ser Gly Ala Thr Gly Phe Phe Ile Ala Leu Val Ala 145 150 155 160 Thr Asn Leu Ile Cys Asp Met Arg Phe Cys Gly Pro Asn Arg Val Asn 165 170 175 His Tyr Phe Cys Asp Met Ala Pro Val Ile Lys Leu Ala Cys Thr Asp 180 185 190 Thr His Val Lys Glu Leu Ala Leu Phe Ser Leu Ser Ile Leu Val Ile 195 200 205 Met Val Pro Phe Leu Leu Ile Leu Ile Ser Tyr Gly Phe Ile Val Asn 210 215 220 Thr Ile Leu Lys Ile Pro Ser Ala Glu Gly Lys Lys Ala Phe Val Thr 225 230 235 240 Cys Ala Ser His Leu Thr Val Val Phe Val His Tyr Gly Cys Ala Ser 245 250 255 Ile Ile Tyr Leu Arg Pro Lys Ser Lys Ser Ala Ser Asp Lys Asp Gln 260 265 270 Leu Val Ala Val Thr Tyr Thr Val Val Thr Pro Leu Leu Asn Pro Leu 275 280 285 Val Tyr Ser Leu Arg Asn Lys Glu Val Lys Thr Ala Leu Lys Arg Val 290 295 300 Leu Gly Met Pro Val Ala Thr Lys Met Ser 305 310 <210> 337 <211> 930 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(930) <400> 337 atg gcc agt aca agt aat gtg act gag ttg att ttc act ggc ctt ttc 48 M et Ala Ser Thr Ser Asn Val Thr Glu Leu Ile Phe Thr Gly Leu Phe 1 5 10 15 cag gat cca gct gtg cag agt gta tgc ttt gtg gtg ttt ctc ccc gtg 96 Gln Asp Pro Ala Val Gln Ser Val Cys Phe Val Val Phe Leu Pro Val 20 25 30 tac ctt gcc acg gtg gtg ggc aat ggc ctc atc gtt ctg acg gtc agt 144 Tyr Leu Ala Thr Val Val Gly Asn Gly Leu Ile Val Leu Thr Val Ser 35 40 45 atc agc aag agt ctg gat tct ccc atg tac ttc ttc ctt agc tgc ctg 192 Ile Ser Lys Ser Leu Asp Ser Pro Met Tyr Phe Phe Leu Ser Cys Leu 50 55 60 tcc ttg gtg gag atc agt tat tcc tcc act atc gcc cct aaa ttc atc 240 Ser Leu Val Glu Ile Ser Tyr Ser Ser Thr Ile Ala Pro Lys Phe Ile 65 70 75 80 ata gac tta ctt gcc aag att aaa acc atc tct ctg gaa ggc tgt ctg 288 Ile Asp Leu Leu Ala Lys Ile Lys Thr Ile Ser Leu Glu Gly Cys Leu 85 90 95 act cag ata ttc ttc ttc cac ttc ttt ggg gtt gct gag atc ctt ttg 336 Thr Gln Ile Phe Phe Phe His Phe Phe Gly Val Ala Glu Ile Leu Leu 100 105 110 att gtg gtg atg gcc tat gat tgc tac gtg gcc att tgc aag cct ctt 384 Ile Val Val Met Ala Tyr Asp Cys Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 cat tat atg aac att atc agt cgt caa ctg tgt cac ctt ctg gtg gct 432 His Tyr Met Asn Ile Ile Ser Arg Gln Leu Cys His Leu Leu Val Ala 130 135 140 ggt tcc tgg ctg ggg ggc ttt tgt cac tcc ata att cag att ctc gtt 480 Gly Ser Trp Leu Gly Gly Phe Cys His Ser Ile Ile Gln Ile Leu Val 145 150 155 160 atc atc caa ttg ccc ttc tgt ggt ccc aat gtg att gac cac tat ttc 528 Ile Ile Gln Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Tyr Phe 165 170 175 tgt gac ctc cag cct tta ttc aag ctt gcc tgc act gac acc ttc atg 576 Cys Asp Leu Gln Pro Leu Phe Lys Leu Ala Cys Thr Asp Thr Phe Met 180 185 190 gag ggg gtt att gtg ttg gcc aac agt gga tta ttc tct gtc ttc tcc 624 Glu Gly Val Ile Val Leu Ala Asn Ser Gly Leu Phe Ser Val Phe Ser 195 200 205 ttc ctc atc ttg gtg tcc tct tat att gtc att ctg gtc aac ttg agg 672 Phe Leu Ile Leu Val Ser Ser Tyr Ile Val Ile Leu Val Asn Leu Arg 210 215 220 aac cat tct gca gag ggg agg cac aaa gcc ctc tcc acc tgt gct tct 720 Asn His Ser Ala Glu Gly Arg His Lys Ala Leu Ser Thr Cys Ala Ser 225 230 235 240 cac atc aca gtg gtc atc ttg ttt ttt gga cct gct atc ttc ctc tac 768 His Ile Thr Val Val Ile Leu Phe Phe Gly Pro Ala Ile Phe Leu Tyr 245 250 255 atg cga cct tct tcc act ttc act gaa gat aaa ctt gtg gct gta ttc 816 Met Arg Pro Ser Ser Thr Phe Thr Glu Asp Lys Leu Val Ala Val Phe 260 265 270 tac acg gtc atc acc ccc atg ctg aac ccc atc att tac aca ctc agg 864 Tyr Thr Val Ile Thr Pro Met Leu Asn Pro Ile Ile Tyr Thr Leu Arg 275 280 285 aat gca gag gtg aaa atc gcc ata aga aga ttg tgg agc aaa aag gag 912 Asn Ala Glu Val Lys Ile Ala Ile Arg Arg Leu Trp Ser Lys Lys Glu 290 295 300 aat cca ggg agg gag tga 930 Asn Pro Gly Arg Glu 305 310 <210> 338 <211> 309 <212> PRT <213> Homo sapiens <400> 338 Met Ala Ser Thr Ser Asn Val Thr Glu Leu Ile Phe Thr Gly Leu Phe 1 5 10 15 Gln Asp Pro Ala Val Gln Ser Val Cys Phe Val Val Phe Leu Pro Val 20 25 30 Tyr Leu Ala Thr Val Val Gly Asn Gly Leu Ile Val Leu Thr Val Ser 35 40 45 Ile Ser Lys Ser Leu Asp Ser Pro Met Tyr Phe Phe Leu Ser Cys Leu 50 55 60 Ser Leu Val Glu Ile Ser Tyr Ser Ser Thr Ile Ala Pro Lys Phe Ile 65 70 75 80 Ile Asp Leu Leu Ala Lys Ile Lys Thr Ile Ser Leu Glu Gly Cys Leu 85 90 95 Thr Gln Ile Phe Phe Phe His Phe Phe Gly Val Ala Glu Ile Leu Leu 100 105 110 Ile Val Val Met Ala Tyr Asp Cys Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Met Asn Ile Ile Ser Arg Gln Leu Cys His Leu Leu Val Ala 130 135 140 Gly Ser Trp Leu Gly Gly Phe Cys His Ser Ile Ile Gln Ile Leu Val 145 150 155 160 Ile Ile Gln Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Tyr Phe 165 170 175 Cys Asp Leu Gln Pro Leu Phe Lys Leu Ala Cys Thr Asp Thr Phe Met 180 185 190 Glu Gly Val Ile Val Leu Ala Asn Ser Gly Leu Phe Ser Val Phe Ser 195 200 205 Phe Leu Ile Leu Val Ser Ser Tyr Ile Val Ile Leu Val Asn Leu Arg 210 215 220 Asn His Ser Ala Glu Gly Arg His Lys Ala Leu Ser Thr Cys Ala Ser 225 230 235 240 His Ile Thr Val Val Ile Leu Phe Phe Gly Pro Ala Ile Phe Leu Tyr 245 250 255 Met Arg Pro Ser Ser Thr Phe Thr Glu Asp Lys Leu Val Ala Val Phe 260 265 270 Tyr Thr Val Ile Thr Pro Met Leu Asn Pro Ile Ile Tyr Thr Leu Arg 275 280 285 Asn Ala Glu Val Lys Ile Ala Ile Arg Arg Leu Trp Ser Lys Lys Glu 290 295 300 Asn Pro Gly Arg Glu 305 <210> 339 <211> 918 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(918) <400> 339 atg gtt gct aca aac aat gtg act gaa ata att ttc gtg gga ttt tcc 48 Met Val Ala Thr Asn Asn Val Thr Glu Ile Ile Phe Val Gly Phe Ser 1 5 10 15 cag aat tgg agt gag cag agg gtc att tct gtg atg ttt ctc ctc atg 96 Gln Asn Trp Ser Glu Gln Arg Val Ile Ser Val Met Phe Leu Leu Met 20 25 30 tac aca gct gtt gtg ctg ggc aat ggc ctc att gtg gtg acc atc ctg 144 Tyr Thr Ala Val Val Leu Gly Asn Gly Leu Ile Val Val Thr Ile Leu 35 40 45 gcc agc aaa gtg ctc acc tcc ccc atg tat ttc ttt ctc agc tac tta 192 Ala Ser Lys Val Leu Thr Ser Pro Met Tyr Phe Phe Leu Ser Tyr Leu 50 55 60 tcc ttt gtg gag atc tgc tac tgt tct gtc atg gcc ccc aag ctt atc 240 Ser Phe Val Glu Ile Cys Tyr Cys Ser Val Met Ala Pro Lys Leu Ile 65 70 75 80 ttt gac tcc ttt atc aag agg aaa gtc att tct ctc aag ggc tgc ctc 288 Phe Asp Ser Phe Ile Lys Arg Lys Val Ile Ser Leu Lys Gly Cys Leu 85 90 95 aca cag atg ttt tcc ctc cat ttc ttt ggt ggc act gag gcc ttt ctc 336 Thr Gln Met Phe Ser Leu His Phe Phe Gly Gly Thr Glu Ala Phe Leu 100 105 110 ctg atg gtg atg gcc tat gac cgc tat gtg gcc atc tgc aag ccc ttg 384 Leu Met Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 cac tac atg gcc atc atg aac cag cga atg tgt ggt ctc ctc gtg agg 432 His Tyr Met Ala Ile Met Asn Gln Arg Met Cys Gly Leu Leu Val Arg 130 135 140 ata gca tgg ggc ggg ggc ctg ctg cat tct gtt ggg caa acc ttc ctg 480 Ile Ala Trp Gly Gly Gly Leu Leu His Ser Val Gly Gln Thr Phe Leu 145 150 155 160 att ttc cag ctc ccg ttc tgt ggc ccc aac atc atg gac cac tac ttc 528 Ile Phe Gln Leu Pro Phe Cys Gly Pro Asn Ile Met Asp His Tyr Phe 165 170 175 tgt gat gtc cac cca gtg ctg gag ctg gcc tgc gca gac acc ttc ttc 576 Cys Asp Val His Pro Val Leu Glu Leu Ala Cys Ala Asp Thr Phe Phe 180 185 190 att agc ctg ctg atc atc acc aat ggc ggc tcc atc tcc gta gtc agt 624 Ile Ser Leu Leu Ile Ile Thr Asn Gly Gly Ser Ile Ser Val Val Ser 195 200 205 ttc ttc gtg ctg atg gct tcc tac ctg atc atc ctg cac ttc ctg aga 672 Phe Phe Val Leu Met Ala Ser Tyr Leu Ile Ile Leu His Phe Leu Arg 210 215 220 agc cac aac ttg gag ggg cag cac aag gcc ctc tcc acc tgt gcc tct 720 Ser His Asn Leu Glu Gly Gln His Lys Ala Leu Ser Thr Cys Ala Ser 225 230 235 240 cat gtc aca gtt gtc gac ctg ttc ttc ata cct tgc tcc ttg gtc tat 768 His Val Thr Val Val Asp Leu Phe Phe Ile Pro Cys Ser Leu Val Tyr 245 250 255 att agg ccc tgt gtc acc ctc cct gca gac aag ata gtt gct gta ttt 816 Ile Arg Pro Cys Val Thr Leu Pro Ala Asp Lys Ile Val Ala Val Phe 260 265 270 tat aca gtg gtc aca cct ctc tta aac cct gtg att tac tcc ttc agg 864 Tyr Thr Val Val Thr Pro Leu Leu Asn Pro Val Ile Tyr Ser Phe Arg 275 280 285 aat gct gaa gtg aaa aat gcc atg agg aga ttt att ggg gga aaa gta 912 Asn Ala Glu Val Lys Asn Ala Met Arg Arg Phe Ile Gly Gly Lys Val 290 295 300 att tga 918 Ile 305 <210> 340 <211> 305 <212> PRT <213> Homo sapiens <400> 340 Met Val Ala Thr Asn Asn Val Thr Glu Ile Ile Phe Val Gly Phe Ser 1 5 10 15 Gln Asn Trp Ser Glu Gln Arg Val Ile Ser Val Met Phe Leu Leu Met 20 25 30 Tyr Thr Ala Val Val Leu Gly Asn Gly Leu Ile Val Val Thr Ile Leu 35 40 45 Ala Ser Lys Val Leu Thr Ser Pro Met Tyr Phe Phe Leu Ser Tyr Leu 50 55 60 Ser Phe Val Glu Ile Cys Tyr Cys Ser Val Met Ala Pro Lys Leu Ile 65 70 75 80 Phe Asp Ser Phe Ile Lys Arg Lys Val Ile Ser Leu Lys Gly Cys Leu 85 90 95 Thr Gln Met Phe Ser Leu His Phe Phe Gly Gly Thr Glu Ala Phe Leu 100 105 110 L eu Met Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Met Ala Ile Met Asn Gln Arg Met Cys Gly Leu Leu Val Arg 130 135 140 Ile Ala Trp Gly Gly Gly Leu Leu His Ser Val Gly Gln Thr Phe Leu 145 150 155 160 Ile Phe Gln Leu Pro Phe Cys Gly Pro Asn Ile Met Asp His Tyr Phe 165 170 175 Cys Asp Val His Pro Val Leu Glu Leu Ala Cys Ala Asp Thr Phe Phe 180 185 190 Ile Ser Leu Leu Ile Ile Thr Asn Gly Gly Ser Ile Ser Val Val Ser 195 200 205 Phe Phe Val Leu Met Ala Ser Tyr Leu Ile Ile Leu His Phe Leu Arg 210 215 220 Ser His Asn Leu Glu Gly Gln His Lys Ala Leu Ser Thr Cys Ala Ser 225 230 235 240 His Val Thr Val Val Asp Leu Phe Phe Ile Pro Cys Ser Leu Val Tyr 245 250 255 Ile Arg Pro Cys Val Thr Leu Pro Ala Asp Lys Ile Val Ala Val Phe 260 265 270 Tyr Thr Val Val Thr Pro Leu Leu Asn Pro Val Ile Tyr Ser Phe Arg 275 280 285 Asn Ala Glu Val Lys Asn Ala Met Arg Arg Phe Ile Gly Gly Lys Val 290 295 300 Ile 305 <210> 341 <211> 912 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(912) <400> 341 atg act gaa ttc att ttt ctg gta ctt tct ccc aac cag gag gtg cag 48 Met Thr Glu Phe Ile Phe Leu Val Leu Ser Pro Asn Gln Glu Val Gln 1 5 10 15 agg gtt tgc ttt gtg ata ttt ctg ttc ttg tac aca gca att gtg ctg 96 Arg Val Cys Phe Val Ile Phe Leu Phe Leu Tyr Thr Ala Ile Val Leu 20 25 30 ggg aat ttc ctc att gtg ctc act gtc atg acc agc aga agc ctt ggt 144 Gly Asn Phe Leu Ile Val Leu Thr Val Met Thr Ser Arg Ser Leu Gly 35 40 45 tcc ccc atg tac ttc ttc ctc agc tac ctc tcc ttc atg gag atc tgc 192 Ser Pro Met Tyr Phe Phe Leu Ser Tyr Leu Ser Phe Met Glu Ile Cys 50 55 60 tac tcc tcc gct aca gcc ccc aaa ctc atc tca gat ctg ctg gct gaa 240 Tyr Ser Ser Ala Thr Ala Pro Lys Leu Ile Ser Asp Leu Leu Ala Glu 65 70 75 80 agg aaa gtc ata tct tgg tgg ggc tgc atg gca cag ctt ttc ttc ttg 288 Arg Lys Val Ile Ser Trp Trp Gly Cys Met Ala Gln Leu Phe Phe Leu 85 90 95 cac ttc ttt ggt ggc act gag att ttc ctg ctc act gtg atg gcc tat 336 His Phe Phe Gly Gly Thr Glu Ile Phe Leu Leu Thr Val Met Ala Tyr 100 105 110 gac cac tat gtg gcc atc tgc aag ccc ctc agc tac acc acc atc atg 384 Asp His Tyr Val Ala Ile Cys Lys Pro Leu Ser Tyr Thr Thr Ile Met 115 120 125 aac tgg cag gtg tgt act gtc ctt gta gga ata gca tgg gtg gga ggc 432 Asn Trp Gln Val Cys Thr Val Leu Val Gly Ile Ala Trp Val Gly Gly 130 135 140 ttc atg cat tcc ttt gca caa atc ctt ctc atc ttc cac ctg ctc ttc 480 Phe Met His Ser Phe Ala Gln Ile Leu Leu Ile Phe His Leu Leu Phe 145 150 155 160 tgt ggc ccc aat gtg atc aat cac tat ttc tgt gac cta gtt ccc ctt 528 Cys Gly Pro Asn Val Ile Asn His Tyr Phe Cys Asp Leu Val Pro Leu 165 170 175 ctc aaa ctt gcc tgc tct gac acc ttc ctc att ggt ctg ctg att gtt 576 Leu Lys Leu Ala Cys Ser Asp Thr Phe Leu Ile Gly Leu Leu Ile Val 180 185 190 gcc aat gga ggc acc ctg tct gtg atc agt ttt ggg gtc ctc tta gca 624 Ala Asn Gly Gly Thr Leu Ser Val Ile Ser Phe Gly Val Leu Leu Ala 195 200 205 tcc tat atg gtc atc ttg ctc cat ctg aga acc tgg agc tct gaa ggg 672 Ser Tyr Met Val Ile Leu Leu His Leu Arg Thr Trp Ser Ser Glu Gly 210 215 220 tgg tgc aaa gcc ctc tcc acc tgt ggg tcc cat ttc gct gtg gtt atc 720 Trp Cys Lys Ala Leu Ser Thr Cys Gly Ser His Phe Ala Val Val Ile 225 230 235 240 ttg ttc ttt ggg ccc tgc gtc ttc aac tct ctg agg cct tct acc act 768 Leu Phe Phe Gly Pro Cys Val Phe Asn Ser Leu Arg Pro Ser Thr Thr 245 250 255 ctg ccc ata gac aag atg gtg gct gtg ttc tac aca gtg ata acc gcg 816 Le u Pro Ile Asp Lys Met Val Ala Val Phe Tyr Thr Val Ile Thr Ala 260 265 270 atc ctg aac cct gtc atc tac tct ctg aga aat gct gaa atg agg aag 864 Ile Leu Asn Pro Val Ile Tyr Ser Leu Arg Asn Ala Glu Met Arg Lys 275 280 285 gcc atg aag agg ctg tgg att agg aca ttg aga cta aat gag aaa tag 912 Ala Met Lys Arg Leu Trp Ile Arg Thr Leu Arg Leu Asn Glu Lys 290 295 300 <210> 342 <211> 303 <212> PRT <213> Homo sapiens <400> 342 Met Thr Glu Phe Ile Phe Leu Val Leu Ser Pro Asn Gln Glu Val Gln 1 5 10 15 Arg Val Cys Phe Val Ile Phe Leu Phe Leu Tyr Thr Ala Ile Val Leu 20 25 30 Gly Asn Phe Leu Ile Val Leu Thr Val Met Thr Ser Arg Ser Leu Gly 35 40 45 Ser Pro Met Tyr Phe Phe Leu Ser Tyr Leu Ser Phe Met Glu Ile Cys 50 55 60 Tyr Ser Ser Ala Thr Ala Pro Lys Leu Ile Ser Asp Leu Leu Ala Glu 65 70 75 80 Arg Lys Val Ile Ser Trp Trp Gly Cys Met Ala Gln Leu Phe Phe Leu 85 90 95 His Phe Phe Gly Gly Thr Glu Ile Phe Leu Leu Thr Val Met Ala Tyr 100 105 110 Asp His Tyr Val Ala Ile Cys Lys Pro Leu Ser Tyr Thr Thr Ile Met 115 120 125 Asn Trp Gln Val Cys Thr Val Leu Val Gly Ile Ala Trp Val Gly Gly 130 135 140 Phe Met His Ser Phe Ala Gln Ile Leu Leu Ile Phe His Leu Leu Phe 145 150 155 160 Cys Gly Pro Asn Val Ile Asn His Tyr Phe Cys Asp Leu Val Pro Leu 165 170 175 Leu Lys Leu Ala Cys Ser Asp Thr Phe Leu Ile Gly Leu Leu Ile Val 180 185 190 Ala Asn Gly Gly Thr Leu Ser Val Ile Ser Phe Gly Val Leu Leu Ala 195 200 205 Ser Tyr Met Val Ile Leu Leu His Leu Arg Thr Trp Ser Ser Glu Gly 210 215 220 Trp Cys Lys Ala Leu Ser Thr Cys Gly Ser His Phe Ala Val Val Ile 225 230 235 240 Leu Phe Phe Gly Pro Cys Val Phe Asn Ser Leu Arg Pro Ser Thr Thr 245 250 255 Leu Pro Ile Asp Lys Met Val Ala Val Phe Tyr Thr Val Ile Thr Ala 260 265 270 Ile Leu Asn Pro Val Ile Tyr Ser Leu Arg Asn Ala Glu Met Arg Lys 275 280 285 Ala Met Lys Arg Leu Trp Ile Arg Thr Leu Arg Leu Asn Glu Lys 290 295 300 <210> 343 <211> 921 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(921) <400> 343 atg act gaa ttc ttt ctg gtg ggg ctt tcc caa tat cca gag ctc cag 48 Met Thr Glu Phe Phe Leu Val Gly Leu Ser Gln Tyr Pro Glu Leu Gln 1 5 10 15 ctt ttt ctg ttc ctg ctc tgc ctc atc atg tac atg ata atc ctc ctg 96 Leu Phe Leu Phe Leu Leu Cys Leu Ile Met Tyr Met Ile Ile Leu Leu 20 25 30 gga aat agc ctc ctc att atc atc acc atc ttg gat tct cgc ctc cat 144 Gly Asn Ser Leu Leu Ile Ile Ile Thr Ile Leu Asp Ser Arg Leu His 35 40 45 act ccc atg tat ttc ttt ctt gga aac ctc tca ttc ttg gac atc tgt 192 Thr Pro Met Tyr Phe Phe Leu Gly Asn Leu Ser Phe Leu Asp Ile Cys 50 55 60 tac aca tcc tca tcc att cct cca atg ctt att ata ttt atg tct gag 240 Tyr Thr Ser Ser Ser Ile Pro Pro Met Leu Ile Ile Phe Met Ser Glu 65 70 75 80 aga aaa tcc atc tcc ttc att ggc tgt gct ctg cag atg gtt gtg tcc 288 Arg Lys Ser Ile Ser Phe Ile Gly Cys Ala Leu Gln Met Val Val Ser 85 90 95 ctt ggc ttg ggc tcc act gag tgt gtc ctc ctg gct gtg atg gcc tat 336 Leu Gly Leu Gly Ser Thr Glu Cys Val Leu Leu Ala Val Met Ala Tyr 100 105 110 gac cac tat gtg gcc atc tgc aac cca ctg agg tac tcc atc atc atg 384 Asp His Tyr Val Ala Ile Cys Asn Pro Leu Arg Tyr Ser Ile Ile Met 115 120 125 aac gga gtg ctg tat gtg caa atg gct gca tgg tcc tgg atc ata ggc 432 Asn Gly Val Leu Tyr Val Gln Met Ala Ala Trp Ser Trp Ile Ile Gly 130 135 140 tgt ctg acc tcc cta ttg caa aca gtt ctg aca atg atg ttg cct ttc 480 Cys Leu Thr Ser Leu Leu Gln Thr Val Leu Thr Met Met Leu Pro Phe 145 150 155 160 tgt ggg aat aat gtc att gat cat att acc tgt gaa att ttg gcc ctt 528 Cys Gly Asn Asn Val Ile Asp His Ile Thr Cys Glu Ile Leu Ala Leu 165 170 175 cta aaa ctt gtt tgt tca gat atc acc atc aat gtg ctt atc atg aca 576 Leu Lys Leu Val Cys Ser Asp Ile Thr Ile Asn Val Leu Ile Met Thr 180 185 190 gt g aca aat att gtt tca ctg gtg att ctt cta ctg tta att ttc atc 624 Val Thr Asn Ile Val Ser Leu Val Ile Leu Leu Leu Leu Ile Phe Ile 195 200 205 tcc tat gtg ttt att ctc tct tcc atc ctg aga att aat tgt gct gag 672 Ser Tyr Val Phe Ile Leu Ser Ser Ile Leu Arg Ile Asn Cys Ala Glu 210 215 220 gga aga aag aaa gcc ttc tct acc tgt tca gcg cac tcg att gtg gtc 720 Gly Arg Lys Lys Ala Phe Ser Thr Cys Ser Ala His Ser Ile Val Val 225 230 235 240 atc tta ttc tac ggt tca gcc ctt ttt atg tac atg aaa ccc aag tca 768 Ile Leu Phe Tyr Gly Ser Ala Leu Phe Met Tyr Met Lys Pro Lys Ser 245 250 255 aag aac act aat aca tct gat gag att att ggg ctg tct tat gga gtg 816 Lys Asn Thr Asn Thr Ser Asp Glu Ile Ile Gly Leu Ser Tyr Gly Val 260 265 270 gta agc cca atg tta aat ccc atc atc tat agc ctc agg aat aaa gag 864 Val Ser Pro Met Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Glu 275 280 285 gtc aaa gag gct gta aag aaa gtc ctg agc aga cat ctg cat tta ttg 912 Val Lys Glu Ala Val Lys Lys Val Leu Ser Arg His Leu His Leu Leu 290 295 300 aaa atg tga 921 Lys Met 305 <210> 344 <211> 306 <212> PRT <213> Homo sapiens <400> 344 Met Thr Glu Phe Phe Leu Val Gly Leu Ser Gln Tyr Pro Glu Leu Gln 1 5 10 15 Leu Phe Leu Phe Leu Leu Cys Leu Ile Met Tyr Met Ile Ile Leu Leu 20 25 30 Gly Asn Ser Leu Leu Ile Ile Ile Thr Ile Leu Asp Ser Arg Leu His 35 40 45 Thr Pro Met Tyr Phe Phe Leu Gly Asn Leu Ser Phe Leu Asp Ile Cys 50 55 60 Tyr Thr Ser Ser Ser Ile Pro Pro Met Leu Ile Ile Phe Met Ser Glu 65 70 75 80 Arg Lys Ser Ile Ser Phe Ile Gly Cys Ala Leu Gln Met Val Val Ser 85 90 95 Leu Gly Leu Gly Ser Thr Glu Cys Val Leu Leu Ala Val Met Ala Tyr 100 105 110 Asp His Tyr Val Ala Ile Cys Asn Pro Leu Arg Tyr Ser Ile Ile Met 115 120 125 Asn Gly Val Leu Tyr Val Gln Met Ala Ala Trp Ser Trp Ile Ile Gly 130 135 140 Cys Leu Thr Ser Leu Leu Gln Thr Val Leu Thr Met Met Leu Pro Phe 145 150 155 160 Cys Gly Asn Asn Val Ile Asp His Ile Thr Cys Glu Ile Leu Ala Leu 165 170 175 Leu Lys Leu Val Cys Ser Asp Ile Thr Ile Asn Val Leu Ile Met Thr 180 185 190 Val Thr Asn Ile Val Ser Leu Val Ile Leu Leu Leu Leu Ile Phe Ile 195 200 205 Ser Tyr Val Phe Ile Leu Ser Ser Ile Leu Arg Ile Asn Cys Ala Glu 210 215 220 Gly Arg Lys Lys Ala Phe Ser Thr Cys Ser Ala His Ser Ile Val Val 225 230 235 240 Ile Leu Phe Tyr Gly Ser Ala Leu Phe Met Tyr Met Lys Pro Lys Ser 245 250 255 Lys Asn Thr Asn Thr Ser Asp Glu Ile Ile Gly Leu Ser Tyr Gly Val 260 265 270 Val Ser Pro Met Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Glu 275 280 285 Val Lys Glu Ala Val Lys Lys Val Leu Ser Arg His Leu His Leu Leu 290 295 300 Lys Met 305 <210> 345 <211> 1029 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1029) <400> 345 atg act gaa aca tcc ctg tct tct cag tgc ttc cct atg tcg gtc ctc 48 Met Thr Glu Thr Ser Leu Ser Ser Gln Cys Phe Pro Met Ser Val Leu 1 5 10 15 aat aat acc att gct gag cct ctg atc ttc ctc ctg atg ggc att cca 96 Asn Asn Thr Ile Ala Glu Pro Leu Ile Phe Leu Leu Met Gly Ile Pro 20 25 30 ggc ctg aaa gcc acc cag tac tgg atc tcc atc cct ttt tgt ctc cta 144 Gly Leu Lys Ala Thr Gln Tyr Trp Ile Ser Ile Pro Phe Cys Leu Leu 35 40 45 tat gtt gtt gcc gtc tct gga aat agc atg atc ctg ttt gtg gtc ctc 192 Tyr Val Val Ala Val Ser Gly Asn Ser Met Ile Leu Phe Val Val Leu 50 55 60 tgt gaa cgg agc ctc cat aag cct atg tac tat ttc ctc tct atg ctt 240 Cys Glu Arg Ser Leu His Lys Pro Met Tyr Tyr Phe Leu Ser Met Leu 65 70 75 80 tca gcc aca gac ctg agc ttg tcc ctg tgt aca ctt tct act acc ctt 288 Ser Ala Thr Asp Leu Ser Leu Ser Leu Cys Thr Leu Ser Thr Thr Leu 85 90 95 ggt gtc ttc tgg ttt gaa gcc cga gaa atc aac cta aat gcc tgc att 336 Gly Val Phe Trp Phe Glu Ala Arg Glu Ile Asn Leu Asn Ala Cys Ile 100 105 110 gcc cag atg ttc ttt cta cac gga ttt act ttc atg gag tct ggg gtt 384 Ala Gln Met Phe Phe Leu His Gly Phe Thr Phe Met Glu Ser Gly Val 115 120 125 cta ctg gcc atg gcc ttt gat cgt ttt gtg gcc atc tgt tac cca ctg 432 Leu Leu Ala Met Ala Phe Asp Arg Phe Val Ala Ile Cys Tyr Pro Leu 130 135 140 aga tac act acc atc ctt acc aat gcc cga att gcc aag att ggg atg 480 Arg Tyr Thr Thr Ile Leu Thr Asn Ala Arg Ile Ala Lys Ile Gly Met 145 150 155 160 agc atg ttg ata aga aat gtt gcc gtc atg ttg cca gtc atg ctc ttt 528 Ser Met Leu Ile Arg Asn Val Ala Val Met Leu Pro Val Met Leu Phe 165 170 175 gtc aag agg ttg tcc ttc tgc agt tct atg gtc ctt tca cat tct tac 576 Val Lys Arg Leu Ser Phe Cys Ser Ser Met Val Leu Ser His Ser Tyr 180 185 190 tgc tac cat gtt gat ctc atc caa ctc tcc tgc aca gac aat agg atc 624 Cys Tyr His Val Asp Leu Ile Gln Leu Ser Cys Thr Asp Asn Arg Ile 195 200 205 aac agc atc ctt ggt ctg ttt gcg ctt ttg tcc act aca ggg ttt gac 672 Asn Ser Ile Leu Gly Leu Phe Ala Leu Leu Ser Thr Thr Gly Phe Asp 210 215 220 tgc cct tgc atc ctg ctc tcc tat atc ctg atc att cga tct gtc ctc 720 Cys Pro Cys Ile Leu Leu Ser Tyr Ile Leu Ile Ile Arg Ser Val Leu 225 230 235 240 agc att gct tcc tca gaa gag agg cgg aaa gcc ttc aac acc tgc aca 768 Se r Ile Ala Ser Ser Glu Glu Arg Arg Lys Ala Phe Asn Thr Cys Thr 245 250 255 tcc cac atc agt gct gtt tcc atc ttc tac ctc cct ctc atc agt ttg 816 Ser His Ile Ser Ala Val Ser Ile Phe Tyr Leu Pro Leu Ile Ser Leu 260 265 270 tct ctt gtc cat cgc tat ggc cat tca gca cct cca ttt gtc cac atc 864 Ser Leu Val His Arg Tyr Gly His Ser Ala Pro Pro Phe Val His Ile 275 280 285 atc atg gcc aat gtc ttt ctg cta atc cct cct gtg ctc aac cct att 912 Ile Met Ala Asn Val Phe Leu Leu Ile Pro Pro Val Leu Asn Pro Ile 290 295 300 att tac agt gta aag att aag cag att caa aag gcc att atc aag gtc 960 Ile Tyr Ser Val Lys Ile Lys Gln Ile Gln Lys Ala Ile Ile Lys Val 305 310 315 320 tta att cag aag cac tcc aaa tct aat cat cag cta ttt ctg att aga 1008 Leu Ile Gln Lys His Ser Lys Ser Asn His Gln Leu Phe Leu Ile Arg 325 330 335 gat aaa gcc att tat gaa taa 1029 Asp Lys Ala Ile Tyr Glu 340 <210> 346 <2 11> 342 <212> PRT <213> Homo sapiens <400> 346 Met Thr Glu Thr Ser Leu Ser Ser Gln Cys Phe Pro Met Ser Val Leu 1 5 10 15 Asn Asn Thr Ile Ala Glu Pro Leu Ile Phe Leu Leu Met Gly Ile Pro 20 25 30 Gly Leu Lys Ala Thr Gln Tyr Trp Ile Ser Ile Pro Phe Cys Leu Leu 35 40 45 Tyr Val Val Ala Val Ser Gly Asn Ser Met Ile Leu Phe Val Val Leu 50 55 60 Cys Glu Arg Ser Leu His Lys Pro Met Tyr Tyr Phe Leu Ser Met Leu 65 70 75 80 Ser Ala Thr Asp Leu Ser Leu Ser Leu Cys Thr Leu Ser Thr Thr Leu 85 90 95 Gly Val Phe Trp Phe Glu Ala Arg Glu Ile Asn Leu Asn Ala Cys Ile 100 105 110 Ala Gln Met Phe Phe Leu His Gly Phe Thr Phe Met Glu Ser Gly Val 115 120 125 Leu Leu Ala Met Ala Phe Asp Arg Phe Val Ala Ile Cys Tyr Pro Leu 130 135 140 Arg Tyr Thr Thr Ile Leu Thr Asn Ala Arg Ile Ala Lys Ile Gly Met 145 150 155 160 Ser Met Leu Ile Arg Asn Val Ala Val Met Leu Pro Val Met Leu Phe 165 170 175 Val Lys Arg Leu Ser Phe Cys Ser Ser Met Val Leu Ser His Ser Tyr 180 185 190 Cys Tyr His Val Asp Leu Ile Gln Leu Ser Cys Thr Asp Asn Arg Ile 195 200 205 Asn Ser Ile Leu Gly Leu Phe Ala Leu Leu Ser Thr Thr Gly Phe Asp 210 215 220 Cys Pro Cys Ile Leu Leu Ser Tyr Ile Leu Ile Ile Arg Ser Val Leu 225 230 235 240 Ser Ile Ala Ser Ser Glu Glu Arg Arg Lys Ala Phe Asn Thr Cys Thr 245 250 255 Ser His Ile Ser Ala Val Ser Ile Phe Tyr Leu Pro Leu Ile Ser Leu 260 265 270 Ser Leu Val His Arg Tyr Gly His Ser Ala Pro Pro Phe Val His Ile 275 280 285 Ile Met Ala Asn Val Phe Leu Leu Ile Pro Pro Val Leu Asn Pro Ile 290 295 300 Ile Tyr Ser Val Lys Ile Lys Gln Ile Gln Lys Ala Ile Ile Lys Val 305 310 315 320 Leu Ile Gln Lys His Ser Lys Ser Asn His Gln Leu Phe Leu Ile Arg 325 330 335 Asp Lys Ala Ile Tyr Glu 340 <210> 347 <211> 903 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(903) <400> 347 atg tac ctg gtc acg gtg ctg agg aac ctg ctc atc atc ctg gct gtc 48 Met Tyr Leu Val Thr Val Leu Arg Asn Leu Leu Ile Ile Leu Ala Val 1 5 10 15 agc tct gac tcc cac ctc cac acc ccc atg tgc ttc ttc ctc tcc aac 96 Ser Ser Asp Ser His Leu His Thr Pro Met Cys Phe Phe Leu Ser Asn 20 25 30 ctg tgc tgg gct gac atc ggt ttc acc tcg gcc atg gtt ccc aag atg 144 Leu Cys Trp Ala Asp Ile Gly Phe Thr Ser Ala Met Val Pro Lys Met 35 40 45 att gtg gac atg cag tcg cat agc aga gtc atc tct tat gcg ggc tgc 192 Ile Val Asp Met Gln Ser His Ser Arg Val Ile Ser Tyr Ala Gly Cys 50 55 60 ctg aca cag atg tct ttc ttt gtc ctt ttt gca tgt ata gaa gac atg 240 Leu Thr Gln Met Ser Phe Phe Val Leu Phe Ala Cys Ile Glu Asp Met 65 70 75 80 ctc ctg aca gtg atg gcc tat gac cga ttt gtg gcc atc tgt cac ccc 288 Leu Leu Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His Pro 85 90 95 ctg cac tac cca gtc atc atg aat cct cac ctt ggt gtc ttc tta gtt 336 Leu His Tyr Pro Val Ile Met Asn Pro His Leu Gly Val Phe Leu Val 100 105 110 ttg gtg tcc ttt ttc ctc agc ctg ttg gat tcc cag ctg cac agt tgg 384 Leu Val Ser Phe Phe Leu Ser Leu Leu Asp Ser Gln Leu His Ser Trp 115 120 125 att gtg tta caa ttc acc ttc ttc aag aat gtg gaa atc tcc aat ttt 432 Ile Val Leu Gln Phe Thr Phe Phe Lys Asn Val Glu Ile Ser Asn Phe 130 135 140 gtc tgt gac cca tct caa ctt ctc aac ctt gcc tgt tct gac agt gtc 480 Val Cys Asp Pro Ser Gln Leu Leu Asn Leu Ala Cys Ser Asp Ser Val 145 150 155 160 atc aat agc ata ttc ata tat tta gat agt att atg ttt ggt ttt ctt 528 Ile Asn Ser Ile Phe Ile Tyr Leu Asp Ser Ile Met Phe Gly Phe Leu 165 170 175 ccc att tca ggg atc ctt ttg tct tac gct aac aat gtc ccc tcc att 576 Pro Ile Ser Gly Ile Leu Leu Ser Tyr Ala Asn Asn Val Pro Ser Ile 180 185 190 cta aga att tca tca tca gat agg aag tct aaa gcc ttc tcc acc tgt 624 Leu Arg Ile Ser Ser Ser Asp Arg Lys Ser Lys Ala Phe Ser Thr Cys 195 200 205 ggc tct cac ctg gca gtt gtt tgc tta ttt tat gga aca ggc att ggc 672 Gly Ser His Leu Ala Val Val Cys Leu Phe Tyr Gly Thr Gly Ile Gly 210 215 220 gt g tac ctg act tca gct gtg tca cca ccc ccc agg aat ggt gtg gtg 720 Val Tyr Leu Thr Ser Ala Val Ser Pro Pro Pro Arg Asn Gly Val Val 225 230 235 240 gca tca gtg atg tac gct gtg gtc acc ccc atg ctg aac cct ttc atc 768 Ala Ser Val Met Tyr Ala Val Val Thr Pro Met Leu Asn Pro Phe Ile 245 250 255 tac agc ctg aga aat agg gac att caa agt gcc ctg tgg agg ctg cgc 816 Tyr Ser Leu Arg Asn Arg Asp Ile Gln Ser Ala Leu Trp Arg Leu Arg 260 265 270 agc aga aca gtc gaa tct cat gat ctg tta tct caa gat ctg ctc cat 864 Ser Arg Thr Val Glu Ser His Asp Leu Leu Ser Gln Asp Leu Leu His 275 280 285 cct ttt tct tgt gtg ggt gag aaa ggt caa cca cat taa 903 Pro Phe Ser Cys Val Gly Glu Lys Gly Gln Pro His 290 295 300 <210> 348 <211> 300 <212> PRT < 213> Homo sapiens <400> 348 Met Tyr Leu Val Thr Val Leu Arg Asn Leu Leu Ile Ile Leu Ala Val 1 5 10 15 Ser Ser Asp Ser His Leu His Thr Pro Met Cys Phe Phe Leu Ser Asn 20 25 30 Leu Cys Trp Ala Asp Ile Gly Phe Thr Ser Ala Met Val Pro Lys Met 35 40 45 Ile Val Asp Met Gln Ser His Ser Arg Val Ile Ser Tyr Ala Gly Cys 50 55 60 Leu Thr Gln Met Ser Phe Phe Val Leu Phe Ala Cys Ile Glu Asp Met 65 70 75 80 Leu Leu Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His Pro 85 90 95 Leu His Tyr Pro Val Ile Met Asn Pro His Leu Gly Val Phe Leu Val 100 105 110 Leu Val Ser Phe Phe Leu Ser Leu Leu Asp Ser Gln Leu His Ser Trp 115 120 125 Ile Val Leu Gln Phe Thr Phe Phe Lys Asn Val Glu Ile Ser Asn Phe 130 135 140 Val Cys Asp Pro Ser Gln Leu Leu Asn Leu Ala Cys Ser Asp Ser Val 145 150 155 160 Ile Asn Ser Ile Phe Ile Tyr Leu Asp Ser Ile Met Phe Gly Phe Leu 165 170 175 Pro Ile Ser Gly Ile Leu Leu Ser Tyr Ala Asn Asn Val Pro Ser Ile 180 185 190 Leu Arg Ile Ser Ser Ser Asp Arg Lys Ser Lys Ala Phe Ser Thr Cys 195 200 205 Gly Ser His Leu Ala Val Val Cys Leu Phe Tyr Gly Thr Gly Ile Gly 210 215 220 Val Tyr Leu Thr Ser Ala Val Ser Pro Pro Pro Arg Asn Gly Val Val 225 230 235 240 Ala Ser Val Met Tyr Ala Val Val Thr Pro Met Leu Asn Pro Phe Ile 245 250 255 Tyr Ser Leu Arg Asn Arg Asp Ile Gln Ser Ala Leu Trp Arg Leu Arg 260 265 270 Ser Arg Thr Val Glu Ser His Asp Leu Leu Ser Gln Asp Leu Leu His 275 280 285 Pro Phe Ser Cys Val Gly Glu Lys Gly Gln Pro His 290 295 300 <210> 349 <211> 993 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(993) <400> 349 atg tgt tct ttt ttc ttg tgc caa aca ggt aaa cag gca aaa ata tca 48 Met Cys Ser Phe Phe Leu Cys Gln Thr Gly Lys Gln Ala Lys Ile Ser 1 5 10 15 atg gga gaa gaa aac caa acc ttt gtg tcc aag ttt atc ttc ctg ggt 96 Met Gly Glu Glu Asn Gln Thr Phe Val Ser Lys Phe Ile Phe Leu Gly 20 25 30 ctt tca cag gac ttg cag acc cag atc ctg cta ttt atc ctt ttc ctc 144 Leu Ser Gln Asp Leu Gln Thr Gln Ile Leu Leu Phe Ile Leu Phe Leu 35 40 45 atc att tat ctg ctg acc gtg ctt gga aac cag ctc atc atc att ctc 192 Ile Ile Tyr Leu Leu Thr Val Leu Gly Asn Gln Leu Ile Ile Ile Leu 50 55 60 atc ttc ctg gat tct cgc ctt cac act ccc atg tat ttt ttt ctt aga 240 Ile Phe Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Arg 65 70 75 80 aat ctc tcc ttt gca gat ctc tgt ttc tct act agc att gtc cct caa 288 Asn Leu Ser Phe Ala Asp Leu Cys Phe Ser Thr Ser Ile Val Pro Gln 85 90 95 gtg ttg gtt cac ttc ttg gta aag agg aaa acc att tct ttt tat ggg 336 Val Leu Val His Phe Leu Val Lys Arg Lys Thr Ile Ser Phe Tyr Gly 100 105 110 tgt atg aca cag ata att gtc ttt ctt ctg gtt ggg tgt aca gag tgt 384 Cys Met Thr Gln Ile Ile Val Phe Leu Leu Val Gly Cys Thr Glu Cys 115 120 125 gcg ctg ctg gca gtg atg tcc tat gac cgg tat gtg gct gtc tgc aag 432 Ala Leu Leu Ala Val Met Ser Tyr Asp Arg Tyr Val Ala Val Cys Lys 130 135 140 ccc ctg tac tac tct acc atc atg aca caa cgg gtg tgt ctc tgg ctg 480 Pro Leu Tyr Tyr Ser Thr Ile Met Thr Gln Arg Val Cys Leu Trp Leu 145 150 155 160 tcc ttc agg tcc tgg gcc agt ggg gca cta gtg tct tta gta gat acc 528 Ser Phe Arg Ser Trp Ala Ser Gly Ala Leu Val Ser Leu Val Asp Thr 165 170 175 agc ttt act ttc cat ctt ccc tac tgg gga cag aat ata atc aat cac 576 Ser Phe Thr Phe His Leu Pro Tyr Trp Gly Gln Asn Ile Ile Asn His 180 185 190 tac ttt tgt gaa cct cct gcc ctc ctg aag ctg gct tcc ata gac act 624 Tyr Phe Cys Glu Pro Pro Ala Leu Leu Lys Leu Ala Ser Ile Asp Thr 195 200 205 tac agc aca gaa atg gcc atc ttt tca atg ggc gtg gta atc ctc ctg 672 Tyr Ser Thr Glu Met Ala Ile Phe Ser Met Gly Val Val Ile Leu Leu 210 215 220 gcc cct gtc tcc ctg att ctt ggt tct tat tgg aat att atc tcc act 720 Ala Pro Val Ser Leu Ile Leu Gly Ser Tyr Trp Asn Ile Ile Ser Thr 225 230 235 240 gtt atc cag atg cag tct ggg gaa ggg aga ctc aag gct ttt tcc acc 768 Val Ile Gln Met Gln Ser Gly Glu Gly Arg Leu Lys Ala Phe Ser Thr 245 250 255 tgt ggc tcc cat ctt att gtt gtt gtc ctc ttc tat ggg tca gga ata 816 Cys Gly Ser His Leu Ile Val Val Val Leu Phe Tyr Gly Ser Gly Ile 260 265 270 ttc acc tac atg cga cca aac tcc aag act aca aaa gaa ctg gat aaa 864 Ph e Thr Tyr Met Arg Pro Asn Ser Lys Thr Thr Lys Glu Leu Asp Lys 275 280 285 atg ata tct gtg ttc tat aca gcg gtg act cca atg ttg aac ccc ata 912 Met Ile Ser Val Phe Tyr Thr Ala Val Thr Pro Met Leu Asn Pro Ile 290 295 300 att tat agc ttg agg aac aaa gat gtc aaa ggg gct ctc agg aaa cta 960 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Gly Ala Leu Arg Lys Leu 305 310 315 320 gtt ggg aga aag tgc ttc tct cat agg cag tga 993 Val Gly Arg Lys Cys Phe Ser His Arg Gln 325 330 <210> 350 <211> 330 <212> PRT <213> Homo sapiens <400> 350 Met Cys Ser Phe Phe Leu Cys Gln Thr Gly Lys Gln Ala Lys Ile Ser 1 5 10 15 Met Gly Glu Glu Asn Gln Thr Phe Val Ser Lys Phe Ile Phe Leu Gly 20 25 30 Leu Ser Gln Asp Leu Gln Thr Gln Ile Leu Leu Phe Ile Leu Phe Leu 35 40 45 Ile Ile Tyr Leu Leu Thr Val Leu Gly Asn Gln Leu Ile Ile Ile Leu 50 55 60 Ile Phe Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Arg 65 70 75 80 Asn Leu Ser Phe Ala Asp Leu Cys Phe Ser Thr Ser Ile Val Pro Gln 85 90 95 Val Leu Val His Phe Leu Val Lys Arg Lys Thr Ile Ser Phe Tyr Gly 100 105 110 Cys Met Thr Gln Ile Ile Val Phe Leu Leu Val Gly Cys Thr Glu Cys 115 120 125 Ala Leu Leu Ala Val Met Ser Tyr Asp Arg Tyr Val Ala Val Cys Lys 130 135 140 Pro Leu Tyr Tyr Ser Thr Ile Met Thr Gln Arg Val Cys Leu Trp Leu 145 150 155 160 Ser Phe Arg Ser Trp Ala Ser Gly Ala Leu Val Ser Leu Val Asp Thr 165 170 175 Ser Phe Thr Phe His Leu Pro Tyr Trp Gly Gln Asn Ile Ile Asn His 180 185 190 Tyr Phe Cys Glu Pro Pro Ala Leu Leu Lys Leu Ala Ser Ile Asp Thr 195 200 205 Tyr Ser Thr Glu Met Ala Ile Phe Ser Met Gly Val Val Ile Leu Leu 210 215 220 Ala Pro Val Ser Leu Ile Leu Gly Ser Tyr Trp Asn Ile Ile Ser Thr 225 230 235 240 Val Ile Gln Met Gln Ser Gly Glu Gly Arg Leu Lys Ala Phe Ser Thr 245 250 255 Cys Gly Ser His Leu Ile Val Val Val Leu Phe Tyr Gly Ser Gly Ile 260 265 270 Phe Thr Tyr Met Arg Pro Asn Ser Lys Thr Thr Lys Glu Leu Asp Lys 275 280 285 Met Ile Ser Val Phe Tyr Thr Ala Val Thr Pro Met Leu Asn Pro Ile 290 295 300 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Gly Ala Leu Arg Lys Leu 305 310 315 320 Val Gly Arg Lys Cys Phe Ser His Arg Gln 325 330 <210> 351 <211> 972 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(972) <400> 351 atg agt cac acc aat gtt acc atc ttc cat cct gca gtt ttt gtc ctt 48 Met Ser His Thr Asn Val Thr Ile Phe His Pro Ala Val Phe Val Leu 1 5 10 15 cct ggc atc cct ggg ttg gag gct tat cac att tgg ctg tca ata cct 96 Pro Gly Ile Pro Gly Leu Glu Ala Tyr His Ile Trp Leu Ser Ile Pro 20 25 30 ctt tgc ctc att tac atc act gca gtc ctg gga aac agc atc ctg ata 144 Leu Cys Leu Ile Tyr Ile Thr Ala Val Leu Gly Asn Ser Ile Leu Ile 35 40 45 gtg gtt att gtc atg gaa cgt aac ctt cat gtg ccc atg tat ttc ttc 192 Val Val Ile Val Met Glu Arg Asn Leu His Val Pro Met Tyr Phe Phe 50 55 60 ctc tca atg ctg gcc gtc atg gac atc ctg ctg tct acc acc act gtg 240 Leu Ser Met Leu Ala Val Met Asp Ile Leu Leu Ser Thr Thr Thr Val 65 70 75 80 ccc aag gcc cta gcc atc ttt tgg ctt caa gca cat aac att gct ttt 288 Pro Lys Ala Leu Ala Ile Phe Trp Leu Gln Ala His Asn Ile Ala Phe 85 90 95 gat gcc tgt gtc acc caa ggc ttc ttt gtc cat atg atg ttt gtg ggg 336 Asp Ala Cys Val Thr Gln Gly Phe Phe Val His Met Met Phe Val Gly 100 105 110 gag tca gct atc ctg tta gcc atg gcc ttt gat cgc ttt gtg gcc att 384 G lu Ser Ala Ile Leu Leu Ala Met Ala Phe Asp Arg Phe Val Ala Ile 115 120 125 tgt gcc cca ctg aga tat aca aca gtg cta aca tgg cct gtt gtg ggg 432 Cys Ala Pro Leu Arg Tyr Thr Thr Val Leu Thr Trp Pro Val Val Gly 130 135 140 agg att gct ctg gcc gtc atc acc cga agc ttc tgc atc atc ttc cca 480 Arg Ile Ala Leu Ala Val Ile Thr Arg Ser Phe Cys Ile Ile Phe Pro 145 150 155 160 gtc ata ttc ttg ctg aag cgg ctg ccc ttc tgc cta acc aac att gtt 528 Val Ile Phe Leu Leu Lys Arg Leu Pro Phe Cys Leu Thr Asn Ile Val 165 170 175 cct cac tcc tac tgt gag cat att gga gtg gct cgt tta gcc tgt gct 576 Pro His Ser Tyr Cys Glu His Ile Gly Val Ala Arg Leu Ala Cys Ala 180 185 190 gac atc act gtt aac att tgg tat ggc ttc tca gtg ccc att gtc atg 624 Asp Ile Thr Val Asn Ile Trp Tyr Gly Phe Ser Val Pro Ile Val Met 195 200 205 gtc atc ttg gat gtt atc ctc atc gct gtg tct tac tca ctg atc ctc 672 Val Ile Leu Asp Val Ile Leu Ile Ala Val Ser Tyr Ser Leu Ile Leu 210 215 220 cga gca gtg ttt cgt ttg ccc tcc cag gat gct cgg cac aag gcc ctc 720 Arg Ala Val Phe Arg Leu Pro Ser Gln Asp Ala Arg His Lys Ala Leu 225 230 235 240 agc act tgt ggc tcc cac ctc tgt gtc atc ctt atg ttt tat gtt cca 768 Ser Thr Cys Gly Ser His Leu Cys Val Ile Leu Met Phe Tyr Val Pro 245 250 255 tcc ttc ttt acc tta ttg acc cat cat ttt ggg cgt aat att cct caa 816 Ser Phe Phe Thr Leu Leu Thr His His Phe Gly Arg Asn Ile Pro Gln 260 265 270 cat gtc cat atc ttg ctg gcc aat ctt tat gtg gca gtg cca cca atg 864 His Val His Ile Leu Leu Ala Asn Leu Tyr Val Ala Val Pro Pro Met 275 280 285 ctg aac ccc att gtc tat ggt gtg aag act aag cag ata cgt gag ggt 912 Leu Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Gln Ile Arg Glu Gly 290 295 300 gta gcc cac cgg ttc ttt gac atc aag act tgg tgc tgt acc tcc cct 960 Val Ala His Arg Phe Phe Asp Ile Lys Thr Trp Cys Cys Thr Ser Pro 305 310 315 320 ctg ggc tca tga 972 Leu Gly Ser <210> 352 <211> 323 <212> PRT <213> Homo sapiens <400> 352 Met Ser His Thr Asn Val Thr Ile Phe His Pro Ala Val Phe Val Leu 1 5 10 15 Pro Gly Ile Pro Gly Leu Glu Ala Tyr His Ile Trp Leu Ser Ile Pro 20 25 30 Leu Cys Leu Ile Tyr Ile Thr Ala Val Leu Gly Asn Ser Ile Leu Ile 35 40 45 Val Val Ile Val Met Glu Arg Asn Leu His Val Pro Met Tyr Phe Phe 50 55 60 Leu Ser Met Leu Ala Val Met Asp Ile Leu Leu Ser Thr Thr Thr Val 65 70 75 80 Pro Lys Ala Leu Ala Ile Phe Trp Leu Gln Ala His Asn Ile Ala Phe 85 90 95 Asp Ala Cys Val Thr Gln Gly Phe Phe Val His Met Met Phe Val Gly 100 105 110 Glu Ser Ala Ile Leu Leu Ala Met Ala Phe Asp Arg Phe Val Ala Ile 115 120 125 Cys Ala Pro Leu Arg Tyr Thr Thr Val Leu Thr Trp Pro Val Val Gly 130 135 140 Arg Ile Ala Leu Ala Val Ile Thr Arg Ser Phe Cys Ile Ile Phe Pro 145 150 155 160 Val Ile Phe Leu Leu Lys Arg Leu Pro Phe Cys Leu Thr Asn Ile Val 165 170 175 Pro His Ser Tyr Cys Glu His Ile Gly Val Ala Arg Leu Ala Cys Ala 180 185 190 Asp Ile Thr Val Asn Ile Trp Tyr Gly Phe Ser Val Pro Ile Val Met 195 200 205 Val Ile Leu Asp Val Ile Leu Ile Ala Val Ser Tyr Ser Leu Ile Leu 210 215 220 Arg Ala Val Phe Arg Leu Pro Ser Gln Asp Ala Arg His Lys Ala Leu 225 230 235 240 Ser Thr Cys Gly Ser His Leu Cys Val Ile Leu Met Phe Tyr Val Pro 245 250 255 Ser Phe Phe Thr Leu Leu Thr His His Phe Gly Arg Asn Ile Pro Gln 260 265 270 His Val His Ile Leu Leu Ala Asn Leu Tyr Val Ala Val Pro Pro Met 275 280 285 Leu Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Gln Ile Arg Glu Gly 290 295 300 Val Ala His Arg Phe Phe Asp Ile Lys Thr Trp Cys Cys Thr Ser Pro 305 310 315 320 Leu Gly Ser <210> 353 <211> 990 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(990) <400> 353 atg tcc agc act ctt ggc cac aac atg gaa tct cct aat cac act gat 48 Met Ser Ser Thr Leu Gly His Asn Met Glu Ser Pro Asn His Thr Asp 1 5 10 15 gtt gac cct tct gtc ttc ttc ctc ctg ggc atc cca ggt ctg gaa caa 96 Val Asp Pro Ser Val Phe Phe Leu Leu Gly Ile Pro Gly Leu Glu Gln 20 25 30 ttt cat ttg tgg ctc tca ctc cct gtg tgt ggc tta ggc aca gcc aca 144 Phe His Leu Trp Leu Ser Leu Pro Val Cys Gly Leu Gly Thr Ala Thr 35 40 45 att gtg ggc aat ata act att ctg gtt gtt gtt gcc act gaa cca gtc 192 Ile Val Gly Asn Ile Thr Ile Leu Val Val Val Ala Thr Glu Pro Val 50 55 60 ttg cac aag cct gtg tac ctt ttt ctg tgc atg ctc tca acc atc gac 240 Leu His Lys Pro Val Tyr Leu Phe Leu Cys Met Leu Ser Thr Ile Asp 65 70 75 80 ttg gct gcc tct gtc tcc aca gtt ccc aag cta ctg gct atc ttc tgg 288 Leu Ala Ala Ser Val Ser Thr Val Pro Lys Leu Leu Ala Ile Phe Trp 85 90 95 tgt gga gcc gga cat ata tct gcc tct gcc tgc ctg gca cag atg ttc 336 Cys Gly Ala Gly His Ile Ser Ala Ser Ala Cys Leu Ala Gln Met Phe 100 105 110 ttc att cat gcc ttc tgc atg atg gag tcc act gtg cta ctg gcc atg 384 Phe Ile His Ala Phe Cys Met Met Glu Ser Thr Val Leu Leu Ala Met 115 120 125 gcc ttt gat cgc tac gtg gcc atc tgc cac cca ctc cgc tat gcc aca 432 Ala Phe Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr Ala Thr 130 135 140 atc ctc act gac acc atc att gcc cac ata ggg gtg gca gct gta gtg 480 Ile Leu Thr Asp Thr Ile Ile Ala His Ile Gly Val Ala Ala Val Val 145 150 155 160 cga ggc tcc ctg ctc atg ctc cca tgt ccc ttc ctt att ggg cgt ttg 528 Arg Gly Ser Leu Leu Met Leu Pro Cys Pro Phe Leu Ile Gly Arg Leu 165 170 175 aac ttc tgc caa agc cat gtg atc cta cac acg tac tgt gag cac atg 576 Asn Phe Cys Gln Ser His Val Ile Leu His Thr Tyr Cys Glu His Met 180 185 190 gct gtg gtg aag ctg gcc tgt gga gac acc agg cct aac cgt gtg tat 624 Ala Val Val Lys Leu Ala Cys Gly Asp Thr Arg Pro Asn Arg Val Tyr 195 200 205 ggg ctg aca gct gca ctg ttg gtc att ggg gtt gac ttg ttt tgc att 672 Gly Leu Thr Ala Ala Leu Leu Val Ile Gly Val Asp Leu Phe Cys Ile 210 215 220 ggt ctc tcc tat gcc cta agt gca caa gct gtc ctt cgc ctc tca tcc 720 Gly Leu Ser Tyr Ala Leu Ser Ala Gln Ala Val Leu Arg Leu Ser Ser 225 230 235 240 cat gaa gct cgg tcc aag gcc cta ggg acc tgt ggt tcc cat gtc tgt 768 His Glu Ala Arg Ser Lys Ala Leu Gly Thr Cys Gly Ser His Val Cys 245 250 255 gtc atc ctc atc tct tat aca cca gcc ctc ttc tcc ttt ttt aca cac 816 Val Ile Leu Ile Ser Tyr Thr Pro Ala Leu Phe Ser Phe Phe Thr His 260 265 270 cgc ttt ggc cat cac gtt cca gtc cat att cac att ctt ttg gcc aat 864 Arg Phe Gly His His Val Pro Val His Ile His Ile Leu Leu Ala Asn 275 280 285 gtt tat ctg ctt ttg cca cct gct ctt aat cct gtg gta tat gga gtt 912 Val Tyr Leu Leu Leu Pro Pro Ala Leu Asn Pro Val Val Tyr Gly Val 290 295 300 aag acc aaa cag atc cgt aaa aga gtt gtc agg gtg ttt caa agt ggg 960 Lys Thr Lys Gln Ile Arg Lys Arg Val Val Arg Val Phe Gln Ser Gly 305 310 315 320 cag gga atg ggc atc aag gca tct gag tga 990 Gln Gly Met Gly Ile Lys Ala Ser Glu 325 330 <210> 354 <211> 329 <212> PRT <213> Homo sapiens <400> 354 Met Ser Ser Thr Leu Gly His Asn Met Glu Ser Pro Asn His Thr Asp 1 5 10 15 Val Asp Pro Ser Val Phe Phe Leu Leu Gly Ile Pro Gly Leu Glu Gln 20 25 30 Phe His Leu Trp Leu Ser Leu Pro Val Cys Gly Leu Gly Thr Ala Thr 35 40 45 Ile Val Gly Asn Ile Thr Ile Leu Val Val Val Ala Thr Glu Pro Val 50 55 60 Leu His Lys Pro Val Tyr Leu Phe Leu Cys Met Leu Ser Thr Ile Asp 65 70 75 80 Leu Ala Ala Ser Val Ser Thr Val Pro Lys Leu Leu Ala Ile Phe Trp 85 90 95 Cys Gly Ala Gly His Ile Ser Ala Ser Ala Cys Leu Ala Gln Met Phe 100 105 110 Phe Ile His Ala Phe Cys Met Met Glu Ser Thr Val Leu Leu Ala Met 115 120 125 Ala Phe Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr Ala Thr 130 135 140 Ile Leu Thr Asp Thr Ile Ile Ala His Ile Gly Val Ala Ala Val Val 145 150 155 160 Arg Gly Ser Leu Leu Met Leu Pro Cys Pro Phe Leu Ile Gly Arg Leu 165 170 175 Asn Phe Cys Gln Ser His Val Ile Leu His Thr Tyr Cys Glu His Met 180 185 190 Ala Val Val Lys Leu Ala Cys Gly Asp Thr Arg Pro Asn Arg Val Tyr 195 200 205 Gly Leu Thr Ala Ala Leu Leu Val Ile Gly Val Asp Leu Phe Cys Ile 210 215 220 Gly Leu Ser Tyr Ala Leu Ser Ala Gln Ala Val Leu Arg Leu Ser Ser 225 230 235 240 His Glu Ala Arg Ser Lys Ala Leu Gly Thr Cys Gly Ser His Val Cys 245 250 255 Val Ile Leu Ile Ser Tyr Thr Pro Ala Leu Phe Ser Phe Phe Thr His 260 265 270 Arg Phe Gly His His Val Pro Val His Ile His Ile Leu Leu Ala Asn 275 280 285 Val Tyr Leu Leu Leu Pro Pro Ala Leu Asn Pro Val Val Tyr Gly Val 290 295 300 Ly s Thr Lys Gln Ile Arg Lys Arg Val Val Arg Val Phe Gln Ser Gly 305 310 315 320 Gln Gly Met Gly Ile Lys Ala Ser Glu 325 <210> 355 <211> 1200 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1200) <400> 355 atg tct ttc act tct ctc ata ccc tca ctc tgt ttc tcc ttg act ctc 48 Met Ser Phe Thr Ser Leu Ile Pro Ser Leu Cys Phe Ser Leu Thr Leu 1 5 10 15 cca ttc ctg ttt tgt tat ctt tct tta ttg ccg ttt ctt tct gct ttt 96 Pro Phe Leu Phe Cys Tyr Leu Ser Leu Leu Pro Phe Leu Ser Ala Phe 20 25 30 ct g ttt atc act cgc tgg cta ctt gcc ttt ctc tct cta ttc tct gtc 144 Leu Phe Ile Thr Arg Trp Leu Leu Ala Phe Leu Ser Leu Phe Ser Val 35 40 45 tct gtc cct gtt tct tct gtt tca agt tca atg gtt ctc tgt ctc tat 192 Ser Val Pro Val Ser Ser Val Ser Ser Ser Met Val Leu Cys Leu Tyr 50 55 60 ctc tct gtt tct gcc tct ccg tct gtc ttt tgt ttc tct tgc atg cag 240 Leu Ser Val Ser Ala Ser Pro Ser Val Phe Cys Phe Ser Cys Met Gln 65 70 75 80 ggc ccc ata ctg tgg atc atg gca aat ctg agc cag ccc tcc gaa ttt 288 Gly Pro Ile Leu Trp Ile Met Ala Asn Leu Ser Gln Pro Ser Glu Phe 85 90 95 gtc ctc ttg ggc ttc tcc tcc ttt ggt gag ctg cag gcc ctt ctg tat 336 Val Leu Leu Gly Phe Ser Ser Phe Gly Glu Leu Gln Ala Leu Leu Tyr 100 105 110 ggc ccc ttc ctc atg ctt tat ctt ctc gcc ttc atg gga aac acc atc 384 Gly Pro Phe Leu Met Leu Tyr Leu Leu Ala Phe Met Gly Asn Thr Ile 115 120 125 atc ata gtt atg gtc ata gct gac acc cac cta cat aca ccc atg tac 432 Ile Ile Val Met Val Ile Ala Asp Thr His Leu His Thr Pro Met Tyr 130 135 140 ttc ttc ctg ggc aat ttt tcc ctg ctg gag atc ttg gta acc atg act 480 Phe Phe Leu Gly Asn Phe Ser Leu Leu Glu Ile Leu Val Thr Met Thr 145 150 155 160 gca gtg ccc agg atg ctc tca gac ctg ttg gtc ccc cac aaa gtc att 528 Ala Val Pro Arg Met Leu Ser Asp Leu Leu Val Pro His Lys Val Ile 165 170 175 acc ttc act ggc tgc atg gtc cag ttc tac ttc cac ttt tcc ctg ggg 576 Thr Phe Thr Gly Cys Met Val Gln Phe Tyr Phe His Phe Ser Leu Gly 180 185 190 tcc acc tcc ttc ctc atc ctg aca gac atg gcc ctt gat cgc ttt gtg 624 Ser Thr Ser Phe Leu Ile Leu Thr Asp Met Ala Leu Asp Arg Phe Val 195 200 205 gcc atc tgc cac cca ctg cgc tat ggc act ctg atg agc cgg gct atg 672 Ala Ile Cys His Pro Leu Arg Tyr Gly Thr Leu Met Ser Arg Ala Met 210 215 220 tgt gtc cag ctg gct ggg gct gcc tgg gca gct cct ttc cta gcc atg 720 Cys Val Gln Leu Ala Gly Ala Ala Trp Ala Ala Pro Phe Leu Ala Met 2 25 230 235 240 gta ccc act gtc ctc tcc cga gct cat ctt gat tac tgc cat ggc gac 768 Val Pro Thr Val Leu Ser Arg Ala His Leu Asp Tyr Cys His Gly Asp 245 250 255 gtc atc aac cac ttc ttc tgt gac aat gaa cct ctc ctg cag ttg tca 816 Val Ile Asn His Phe Phe Cys Asp Asn Glu Pro Leu Leu Gln Leu Ser 260 265 270 tgc tct gac act cgc ctg ttg gaa ttc tgg gac ttt ctg atg gcc ttg 864 Cys Ser Asp Thr Arg Leu Leu Glu Phe Trp Asp Phe Leu Met Ala Leu 275 280 285 acc ttt gtc ctc agc tcc ttc ctg gtg acc ctc atc tcc tat ggc tac 912 Thr Phe Val Leu Ser Ser Phe Leu Val Thr Leu Ile Ser Tyr Gly Tyr 290 295 300 ata gtg acc act gtg ctg cgg atc ccc tct gcc agc agc tgc cag aag 960 Ile Val Thr Thr Val Leu Arg Ile Pro Ser Ala Ser Ser Cys Gln Lys 305 310 315 320 gct ttc tcc act tgc ggg tct cac ctc aca ctg gtc ttc atc ggc tac 1008 Ala Phe Ser Thr Cys Gly Ser His Leu Thr Leu Val Phe Ile Gly Tyr 325 330 335 agt agt acc atc ttt ctg tat gtc agg cct ggc aaa gct cac tct gtg 1056 Ser Ser Thr Ile Phe Leu Tyr Val Arg Pro Gly Lys Ala His Ser Val 340 345 350 caa gtc agg aag gtc gtg gcc ttg gtg act tca gtt ctc acc ccc ttt 1104 Gln Val Arg Lys Val Val Ala Leu Val Thr Ser Val Leu Thr Pro Phe 355 360 365 ctc aat ccc ttt atc ctt acc ttc tgc aat cag aca gtt aaa aca gtg 1152 Leu Asn Pro Phe Ile Leu Thr Phe Cys Asn Gln Thr Val Lys Thr Val 370 375 380 cta cag ggg cag atg cag agg ctg aaa ggc ctt tgc aag gca caa tga 1200 Leu Gln Gly Gln Met Gln Arg Leu Lys Gly Leu Cys Lys Ala Gln 385 390 395 400 <210> 356 <211> 399 <212> PRT <213> Homo sapiens <400> 356 Met Ser Phe Thr Ser Leu Ile Pro Ser Leu Cys Phe Ser Leu Thr Leu 1 5 10 15 Pro Phe Leu Phe Cys Tyr Leu Ser Leu Leu Pro Phe Leu Ser Ala Phe 20 25 30 Leu Phe Ile Thr Arg Trp Leu Leu Ala Phe Leu Ser Leu Phe Ser Val 35 40 45 Ser Val Pro Val Ser Ser Val Ser Ser Ser Met Val Leu Cys Leu Tyr 50 55 60 Leu Ser Val Ser Ala Ser Pro Ser Val Phe Cys Phe Ser Cys Met Gln 65 70 75 80 Gly Pro Ile Leu Trp Ile Met Ala Asn Leu Ser Gln Pro Ser Glu Phe 85 90 95 Val Leu Leu Gly Phe Ser Ser Phe Gly Glu Leu Gln Ala Leu Leu Tyr 100 105 110 Gly Pro Phe Leu Met Leu Tyr Leu Leu Ala Phe Met Gly Asn Thr Ile 115 120 125 Ile Ile Val Met Val Ile Ala Asp Thr His Leu His Thr Pro Met Tyr 130 135 140 Phe Phe Leu Gly Asn Phe Ser Leu Leu Glu Ile Leu Val Thr Met Thr 145 150 155 160 Ala Val Pro Arg Met Leu Ser Asp Leu Leu Val Pro His Lys Val Ile 165 170 175 Thr Phe Thr Gly Cys Met Val Gln Phe Tyr Phe His Phe Ser Leu Gly 180 185 190 Ser Thr Ser Phe Leu Ile Leu Thr Asp Met Ala Leu Asp Arg Phe Val 195 200 205 Ala Ile Cys His Pro Leu Arg Tyr Gly Thr Leu Met Ser Arg Ala Met 210 215 220 Cys Val Gln Leu Ala Gly Ala Ala Trp Ala Ala Pro Phe Leu Ala Met 225 230 235 240 Val Pro Thr Val Leu Ser Arg Ala His Leu Asp Tyr Cys His Gly Asp 245 250 255 Val Ile Asn His Phe Phe Cys Asp Asn Glu Pro Leu Leu Gln Leu Ser 260 265 270 Cys Ser Asp Thr Arg Leu Leu Glu Phe Trp Asp Phe Leu Met Ala Leu 275 280 285 Thr Phe Val Leu Ser Ser Phe Leu Val Thr Leu Ile Ser Tyr Gly Tyr 290 295 300 Ile Val Thr Thr Val Leu Arg Ile Pro Ser Ala Ser Ser Cys Gln Lys 305 310 315 320 Ala Phe Ser Thr Cys Gly Ser His Leu Thr Leu Val Phe Ile Gly Tyr 325 330 335 Ser Ser Thr Ile Phe Leu Tyr Val Arg Pro Gly Lys Ala His Ser Val 340 345 350 Gln Val Arg Lys Val Val Ala Leu Val Thr Ser Val Leu Thr Pro Phe 355 360 365 Leu Asn Pro Phe Ile Leu Thr Phe Cys Asn Gln Thr Val Lys Thr Val 370 375 380 Leu Gln Gly Gln Met Gln Arg Leu Lys Gly Leu Cys Lys Ala Gln 385 390 395 <210> 357 <211> 933 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(933) <400> 357 atg atg gac aac cac tct agt gcc act gaa ttc cac ctt cta ggc ttc 48 Met Met Asp Asn His Ser Ser Ala Thr Glu Phe His Leu Leu Gly Phe 1 5 10 15 cct ggg tcc caa gga cta cac cac att ctt ttt gct ata ttc ttt ttc 96 Pro Gly Ser Gln Gly Leu His His Ile Leu Phe Ala Ile Phe Phe Phe 20 25 30 ttc tat tta gtg aca tta atg gga aac acg gtc atc att gtg att gtc 144 Phe Tyr Leu Val Thr Leu Met Gly Asn Thr Val Ile Ile Val Ile Val 35 40 45 tgt gtg gat aaa cgt ctg cag tcc ccc atg tat ttc ttc ctc agc cac 192 Cys Val Asp Lys Arg Leu Gln Ser Pro Met Tyr Phe Phe Leu Ser His 50 55 60 ctc tct acc ctg gag atc ctg gtc aca acc ata att gtc ccc atg atg 240 Leu Ser Thr Leu Glu Ile Leu Val Thr Thr Ile Ile Val Pro Met Met 65 70 75 80 ctt tgg gga ttg ctc ttc ctg gga tgc aga cag tat ctt tct cta cat 288 Leu Trp Gly Leu Leu Phe Leu Gly Cys Arg Gln Tyr Leu Ser Leu His 85 90 95 gta tcg ctc aac ttt tcc tgt ggg acc atg gag ttt gca tta ctt gga 336 Val Ser Leu Asn Phe Ser Cys Gly Thr Met Glu Phe Ala Leu Leu Gly 100 105 110 gtg atg gct gtg gac cgt tat gtg gct gtg tgt aac cct ttg agg tac 384 Val Met Ala Val Asp Arg Tyr Val Ala Val Cys Asn Pro Leu Arg Tyr 115 120 125 a ac atc att atg aac agc agt acc tgt att tgg gtg gta ata gtg tca 432 Asn Ile Ile Met Asn Ser Ser Thr Cys Ile Trp Val Val Ile Val Ser 130 135 140 tgg gtg ttt gga ttt ctt tct gaa atc tgg ccc atc tat gcc aca ttt 480 Trp Val Phe Gly Phe Leu Ser Glu Ile Trp Pro Ile Tyr Ala Thr Phe 145 150 155 160 cag ttt acc ttc cgc aaa tca aat tca tta gac cat ttt tac tgt gac 528 Gln Phe Thr Phe Arg Lys Ser Asn Ser Leu Asp His Phe Tyr Cys Asp 165 170 175 cga ggg caa ttg ctc aaa ctg tcc tgc gat aac act ctt ctc aca gag 576 Arg Gly Gln Leu Leu Lys Leu Ser Cys Asp Asn Thr Leu Leu Thr Glu 180 185 190 ttt atc ctt ttc tta atg gct gtt ttt att ctc att ggt tct ttg atc 624 Phe Ile Leu Phe Leu Met Ala Val Phe Ile Leu Ile Gly Ser Leu Ile 195 200 205 cct acg att gtc tcc tac acc tac att atc tcc acc atc ctc aag atc 672 Pro Thr Ile Val Ser Tyr Thr Tyr Ile Ile Ser Thr Ile Leu Lys Ile 210 215 220 ccg tca gcc tct ggc cgg agg aaa gcc ttc tcc act ttt gcc tcc cac 720 Pro Ser Ala Ser Gly Arg Arg Lys Ala Phe Ser Thr Phe Ala Ser His 225 230 235 240 ttc acc tgt gtt gtg att ggc tat ggc agc tgc ttg ttt ctc tac gtg 768 Phe Thr Cys Val Val Ile Gly Tyr Gly Ser Cys Leu Phe Leu Tyr Val 245 250 255 aaa ccc aag caa aca cag gga gtt gag tac aat aag ata gtt tcc ctg 816 Lys Pro Lys Gln Thr Gln Gly Val Glu Tyr Asn Lys Ile Val Ser Leu 260 265 270 ttg gtt tct gtg tta acc ccc ttc ctg aat cct ttc atc ttt act ctt 864 Leu Val Ser Val Leu Thr Pro Phe Leu Asn Pro Phe Ile Phe Thr Leu 275 280 285 cgg aat gac aaa gtc aaa gag gcc ctc cga gat ggg atg aaa cgc tgc 912 Arg Asn Asp Lys Val Lys Glu Ala Leu Arg Asp Gly Met Lys Arg Cys 290 295 300 tgt caa ctc ctg aaa gat tag 933 Cys Gln Leu Leu Lys Asp 305 310 <210> 358 <211> 310 <212> PRT <213> Homo sapiens <400> 358 Met Met Asp Asn His Ser Ser Ala Thr Glu Phe His Leu Leu Gly Phe 1 5 10 15 Pro Gly Ser Gln Gly Leu His His Ile Leu Phe Ala Ile Phe Phe Phe 20 25 30 Phe Tyr Leu Val Thr Leu Met Gly Asn Thr Val Ile Ile Val Ile Val 35 40 45 Cys Val Asp Lys Arg Leu Gln Ser Pro Met Tyr Phe Phe Leu Ser His 50 55 60 Leu Ser Thr Leu Glu Ile Leu Val Thr Thr Ile Ile Val Pro Met Met 65 70 75 80 Leu Trp Gly Leu Leu Phe Leu Gly Cys Arg Gln Tyr Leu Ser Leu His 85 90 95 Val Ser Leu Asn Phe Ser Cys Gly Thr Met Glu Phe Ala Leu Leu Gly 100 105 110 Val Met Ala Val Asp Arg Tyr Val Ala Val Cys Asn Pro Leu Arg Tyr 115 120 125 Asn Ile Ile Met Asn Ser Ser Thr Cys Ile Trp Val Val Ile Val Ser 130 135 140 Trp Val Phe Gly Phe Leu Ser Glu Ile Trp Pro Ile Tyr Ala Thr Phe 145 150 155 160 Gln Phe Thr Phe Arg Lys Ser Asn Ser Leu Asp His Phe Tyr Cys Asp 165 170 175 Arg Gly Gln Leu Leu Lys Leu Ser Cys Asp Asn Thr Leu Leu Thr Glu 180 185 190 Phe Ile Leu Phe Leu Met Ala Val Phe Ile Leu Ile Gly Ser Leu Ile 195 200 205 Pro Thr Ile Val Ser Tyr Thr Tyr Ile Ile Ser Thr Ile Leu Lys Ile 210 215 220 Pro Ser Ala Ser Gly Arg Arg Lys Ala Phe Ser Thr Phe Ala Ser His 225 230 235 240 Phe Thr Cys Val Val Ile Gly Tyr Gly Ser Cys Leu Phe Leu Tyr Val 245 250 255 Lys Pro Lys Gln Thr Gln Gly Val Glu Tyr Asn Lys Ile Val Ser Leu 260 265 270 Leu Val Ser Val Leu Thr Pro Phe Leu Asn Pro Phe Ile Phe Thr Leu 275 280 285 Arg Asn Asp Lys Val Lys Glu Ala Leu Arg Asp Gly Met Lys Arg Cys 290 295 300 Cys Gln Leu Leu Lys Asp 305 310 <210> 359 <211> 669 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(669) <400> 359 atg ctg ctg ggc aac ctg gcc atc atc agc ttc att tgc ctt gat tcc 48 Met Leu Leu Gly Asn Leu Ala Ile Ile Ser Phe Ile Cys Leu Asp Ser 1 5 10 15 cgc ctt cac tca ccc atg tac ttc ttc ctc tgc aac ttc tcc ctc atg 96 Arg Leu His Ser Pro Met Tyr Phe Phe Leu Cys Asn Phe Ser Leu Met 20 25 30 gag atg gtg gtc acc tcc act gtg gta cat agg atg ctg gca gac ctg 144 Glu Met Val Val Thr Ser Thr Val Val His Arg Met Leu Ala Asp Leu 35 40 45 cta tcc act cac aag acc atg tcc ctg gcc aaa tgc cta acc cag tct 192 Leu Ser Thr His Lys Thr Met Ser Leu Ala Lys Cys Leu Thr Gln Ser 50 55 60 ttc ttt tac ttc tcc ctg ggc tct gcc aac ttc ctg ata ctc atg gtc 240 Phe Phe Tyr Phe Ser Leu Gly Ser Ala Asn Phe Leu Ile Leu Met Val 65 70 75 80 atg gcc ttt gat cgc tac gtg gcc atc tgc cac ccc ctg cgc tac cca 288 Met Ala Phe Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr Pro 85 90 95 acc atc acg aat ggt cca gtg tgt gtg aag ctg gtg gtg gcc tgt tgg 336 Thr Ile Thr Asn Gly Pro Val Cys Val Lys Leu Val Val Ala Cys Trp 100 105 110 gtg gtt ggt ttc ctc tcc att gtc tct ccc aca ctg cag aaa aca cga 384 Val Val Gly Phe Leu Ser Ile Val Ser Pro Thr Leu Gln Lys Thr Arg 115 120 125 ctc tgg ttc tgt ggc cct aac atc atc ggc cac tac ttc tgt gac tct 432 Leu Trp Phe Cys Gly Pro Asn Ile Ile Gly His Tyr Phe Cys Asp Ser 130 135 140 gcc ccg ctg ctc aag ctt gcc tgc tct gac acc cgc cac att gag cgc 480 Ala Pro Leu Leu Lys Leu Ala Cys Ser Asp Thr Arg His Ile Glu Arg 145 150 155 160 atg gac ctc ttc ctg tcc ctg ctc ttt gtg ctg acc acc atg ctg ctt 528 Met Asp Leu Phe Leu Ser Leu Leu Phe Val Leu Thr Thr Met Leu Leu 165 170 175 atc atc ctc tcc tac atc ctc att gtg gct gca gtg ctg cac atc cct 576 Ile Ile Leu Ser Tyr Ile Leu Ile Val Ala Ala Val Leu His Ile Pro 180 185 190 tcc tcc tct gga tgc cag aag gcc ttc tcc acc tgt gcc tct cac ctc 624 Ser Ser Ser Gly Cys Gln Lys Ala Phe Ser Thr Cys Ala Ser His Leu 195 200 205 aca gtg gtg gtt ctg ggc tat gca gtg cca tct tca tct acg tga 669 Thr Val Val Val Leu Gly Tyr Ala Val Pro Ser Ser Ser Thr 210 215 220 <210> 360 <211> 222 <212> PRT <213> Homo sapiens <400> 360 Met Leu Leu Gly Asn Leu Ala Ile Ile Ser Phe Ile Cys Leu Asp Ser 1 5 10 15 Arg Leu His Ser Pro Met Tyr Phe Phe Leu Cys Asn Phe Ser Leu Met 20 25 30 Glu Met Val Val Thr Ser Thr Val Val His Arg Met Leu Ala Asp Leu 35 40 45 Leu Ser Thr His Lys Thr Met Ser Leu Ala Lys Cys Leu Thr Gln Ser 50 55 60 Phe Phe Tyr Phe Ser Leu Gly Ser Ala Asn Phe Leu Ile Leu Met Val 65 70 75 80 Met Ala Phe Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr Pro 85 90 95 Thr Ile Thr Asn Gly Pro Val Cys Val Lys Leu Val Val Ala Cys Trp 100 105 110 Val Val Gly Phe Leu Ser Ile Val Ser Pro Thr Leu Gln Lys Thr Arg 115 120 125 Leu Trp Phe Cys Gly Pro Asn Ile Ile Gly His Tyr Phe Cys Asp Ser 130 135 140 Ala Pro Leu Leu Lys Leu Ala Cys Ser Asp Thr Arg His Ile Glu Arg 145 150 155 160 Met Asp Leu Phe Leu Ser Leu Leu Phe Val Leu Thr Thr Met Leu Leu 165 170 175 Ile Ile Leu Ser Tyr Ile Leu Ile Val Ala Ala Val Leu His Ile Pro 180 185 190 Ser Ser Ser Gly Cys Gln Lys Ala Phe Ser Thr Cys Ala Ser His Leu 195 200 205 Thr Val Val Val Leu Gly Tyr Ala Val Pro Ser Ser Ser Thr 210 215 220 <210> 361 <211> 987 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(987) < 400> 361 atg ttt ctg aca gag aga aat acg aca tct gag gcc aca ttc act ctc 48 Met Phe Leu Thr Glu Arg Asn Thr Thr Ser Glu Ala Thr Phe Thr Leu 1 5 10 15 ttg ggc ttc tca gat tac ctg gaa ctg caa att ccc ctc ttc ttt gta 96 Leu Gly Phe Ser Asp Tyr Leu Glu Leu Gln Ile Pro Leu Phe Phe Val 20 25 30 ttt ctg gca gtc tac ggc ttc agt gtg gta ggg aat ctt ggg atg ata 144 Phe Leu Ala Val Tyr Gly Phe Ser Val Val Gly Asn Leu Gly Met Ile 35 40 45 gtg atc atc aaa att aac cca aaa ttg cat acc ccc atg tat ttt ttc 192 Val Ile Ile Lys Ile Asn Pro Lys Leu His Thr Pro Met Tyr Phe Phe 50 55 60 ctc aac cac ctc tcc ttt gtg gat ttc tgc tat tcc tcc atc att gct 240 Leu Asn His Leu Ser Phe Val Asp Phe Cys Tyr Ser Ser Ile Ile Ala 65 70 75 80 ccc atg atg ctg gtg aac ctg gtt gta gaa gat aga acc att tca ttc 288 Pro Met Met Leu Val Asn Leu Val Val Glu Asp Arg Thr Ile Ser Phe 85 90 95 tca gga tgt ttg gtg caa ttc ttt ttc ttt tgc acc ttt gta gtg act 336 Ser Gly Cys Leu Val Gln Phe Phe Phe Phe Cys Thr Phe Val Val Thr 100 105 110 gaa tta att cta ttt gcg gtg atg gcc tat gac cac ttt gtg gcc att 384 Glu Leu Ile Leu Phe Ala Val Met Ala Tyr Asp His Phe Val Ala Ile 115 120 125 tgc aat cct ctg ctc tac aca gtt gcc atc tcc cag aaa ctc tgt gcc 432 Cys Asn Pro Leu Leu Tyr Thr Val Ala Ile Ser Gln Lys Leu Cys Ala 130 135 140 atg ctg gtg gtt gta ttg tat gca tgg gga gtc gca tgt tcc ctg aca 480 Met Leu Val Val Val Leu Tyr Ala Trp Gly Val Ala Cys Ser Leu Thr 145 150 155 160 ctc gcg tgc tct gct tta aag tta tct ttt cat ggt ttc aac aca atc 528 Leu Ala Cys Ser Ala Leu Lys Leu Ser Phe His Gly Phe Asn Thr Ile 165 170 175 aat cat ttc ttc tgt gag tta tcc tcc ctg ata tca ctc tct tac cct 576 Asn His Phe Phe Cys Glu Leu Ser Ser Leu Ile Ser Leu Ser Tyr Pro 180 185 190 gac tct tat ctc agc cag ttg ctt ctt ttc act gtt gcc act ttt aat 624 Asp Ser Tyr Leu Ser Gln Leu Leu Leu Phe Thr Val Ala Thr Phe Asn 195 200 205 gag ata agc aca cta ctc atc att ctg aca tct tat gca ttc atc att 672 Glu Ile Ser Thr Leu Leu Ile Ile Leu Thr Ser Tyr Ala Phe Ile Ile 210 215 220 gtc acc acc ttg aag atg cct tca gcc agt ggg cac cgc aaa gtc ttc 720 Val Thr Thr Leu Lys Met Pro Ser Ala Ser Gly His Arg Lys Val Phe 225 230 235 240 tcc acc tgt gcc tcc cac ctg act gcc atc acc atc ttc cat ggc acc 768 Ser Thr Cys Ala Ser His Leu Thr Ala Ile Thr Ile Phe His Gly Thr 245 250 255 atc ctc ttc ctc tac tgt gta ccc aac tcc aaa aac tcc agg cac aca 816 Ile Leu Phe Leu Tyr Cys Val Pro Asn Ser Lys Asn Ser Arg His Thr 260 265 270 gtc aaa gtg gcc tct gtg ttt tac acc gtg gtg atc ccc ttg ttg aat 864 Val Lys Val Ala Ser Val Phe Tyr Thr Val Val Ile Pro Leu Leu Asn 275 280 285 ccc ctg atc tac agt ctg aga aat aaa gat gtt aag gat gca atc cga 912 Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Asp Ala Ile Arg 290 295 300 aaa ata atc aat aca aaa tat ttt cat att aaa cat agg cat tgg tat 960 Lys Ile Ile Asn Thr Lys Tyr Phe His Ile Lys His Arg His Trp Tyr 305 310 315 320 cca ttt aat ttt gtt att gaa caa taa 987 Pro Phe Asn Phe Val Ile Glu Gln 325 <210> 362 <211> 328 <212> PRT <213> Homo sapiens <400> 362 Met Phe Leu Thr Glu Arg Asn Thr Thr Ser Glu Ala Thr Phe Thr Leu 1 5 10 15 Leu Gly Phe Ser Asp Tyr Leu Glu Leu Gln Ile Pro Leu Phe Phe Val 20 25 30 Phe Leu Ala Val Tyr Gly Phe Ser Val Val Gly Asn Leu Gly Met Ile 35 40 45 Val Ile Ile Lys Ile Asn Pro Lys Leu His Thr Pro Met Tyr Phe Phe 50 55 60 Leu Asn His Leu Ser Phe Val Asp Phe Cys Tyr Ser Ser Ile Ile Ala 65 70 75 80 Pro Met Met Leu Val Asn Leu Val Val Glu Asp Arg Thr Ile Ser Phe 85 90 95 Ser Gly Cys Leu Val Gln Phe Phe Phe Phe Cys Thr Phe Val Val Thr 100 105 110 Glu Leu Ile Leu Phe Ala Val Met Ala Tyr Asp His Phe Val Ala Ile 115 120 125 Cys Asn Pro Leu Leu Tyr Thr Val Ala Ile Ser Gln Lys Leu Cys Ala 130 135 140 Met Leu Val Val Val Leu Tyr Ala Trp Gly Val Ala Cys Ser Leu Thr 145 150 155 160 Leu Ala Cys Ser Ala Leu Lys Leu Ser Phe His Gly Phe Asn Thr Ile 165 170 175 Asn His Phe Phe Cys Glu Leu Ser Ser Leu Ile Ser Leu Ser Tyr Pro 180 185 190 Asp Ser Tyr Leu Ser Gln Leu Leu Leu Phe Thr Val Ala Thr Phe Asn 195 200 205 Glu Ile Ser Thr Leu Leu Ile Ile Leu Thr Ser Tyr Ala Phe Ile Ile 210 215 220 Val Thr Thr Leu Lys Met Pro Ser Ala Ser Gly His Arg Lys Val Phe 225 230 235 240 Ser Thr Cys Ala Ser His Leu Thr Ala Ile Thr Ile Phe His Gly Thr 245 250 255 Ile Leu Phe Leu Tyr Cys Val Pro Asn Ser Lys Asn Ser Arg His Thr 260 265 270 Val Lys Val Ala Ser Val Phe Tyr Thr Val Val Ile Pro Leu Leu Asn 275 280 285 Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Asp Ala Ile Arg 290 295 300 Lys Ile Ile Asn Thr Lys Tyr Phe His Ile Lys His Arg His Trp Tyr 305 310 315 320 Pro Phe Asn Phe Val Ile Glu Gln 325 <210> 363 <211> 936 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(936) <400> 363 atg ggc aag gaa aac tgc acc act gtg gct gag ttc att ctc ctt gga 48 Met Gly Lys Glu Asn Cys Thr Thr Val Ala Glu Phe Ile Leu Leu Gly 1 5 10 15 cta tca gat gtc cct gag ttg aga gtc tgc ctc ttc ctg ctg ttc ctt 96 Leu Ser Asp Val Pro Glu Leu Arg Val Cys Leu Phe Leu Leu Phe Leu 20 25 30 ctc atc tat gga gtc acg ttg tta gcc aat ctg ggc atg act gca ctg 144 Leu Ile Tyr Gly Val Thr Leu Leu Ala Asn Leu Gly Met Thr Ala Leu 35 40 45 att cag gtc agc tct cgg ctc cac acc ccc gtg tac ttt ttc ctc agc 192 Ile Gln Val Ser Ser Arg Leu His Thr Pro Val Tyr Phe Phe Leu Ser 50 55 60 cac ttg tcc ttt gta gat ttc tgc tac tcc tca ata att gtg cca aag 240 His Leu Ser Phe Val Asp Phe Cys Tyr Ser Ser Ile Ile Val Pro Lys 65 70 75 80 atg ttg gct aat atc ttt aac aag gac aaa gcc atc tcc ttc cta ggg 288 Met Leu Ala Asn Ile Phe Asn Lys Asp Lys Ala Ile Ser Phe Leu Gly 85 90 95 tgc atg gtg caa ttc tac ttg ttt tgc aca tgt gga gtc act gag gtc 336 Cys Met Val Gln Phe Tyr Leu Phe Cys Thr Cys Gly Val Thr Glu Val 100 105 110 ttc ctg ctg gcc gtg atg gcc tat gac cgc ttt gtg gcc atc tgt aac 384 Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys Asn 115 120 125 ccc ctg ctg tac atg gtg acc atg tct caa aag ctg cgt gtg gag ctg 432 Pro Leu Leu Tyr Met Val Thr Met Ser Gln Lys Leu Arg Val Glu Leu 130 135 140 acc tct tgc tgc tac ttc tgt ggg acg gtg tgt tct ctg att cac tcg 480 Thr Ser Cys Cys Tyr Phe Cys Gly Thr Val Cys Ser Leu Ile His Ser 145 150 155 160 tcc tta gct ctt agg atc ctc ttc tat aga tct aat gtg att aac cac 528 Ser Leu Ala Leu Arg Ile Leu Phe Tyr Arg Ser Asn Val Ile Asn His 165 170 175 ttc ttc tgt gat cta ccc cct ctc cta agt ctt gct tgc tct gat gtc 576 Phe Phe Cys Asp Leu Pro Pro Leu Leu Ser Leu Ala Cys Ser Asp Val 180 185 190 act gtg aat gag aca ctg ctg ttc ctg gtg gcc act ttg aat gag agt 624 Thr Val Asn Glu Thr Leu Leu Phe Leu Val Ala Thr Leu Asn Glu Ser 195 200 205 gtt acc atc atg atc atc ctc acc tcc tac ctg cta att ctc acc act 672 Val Thr Ile Met Ile Ile Leu Thr Ser Tyr Leu Leu Ile Leu Thr Thr 210 215 220 atc ctg aag ata cac tct gca gag agc agg cac aaa gct ttc tcc acc 720 Ile Leu Lys Ile His Ser Ala Glu Ser Arg His Lys Ala Phe Ser Thr 225 230 235 240 tgt gcc tcc cac ctc aca gcc atc act gtc tcc cat gga aca atc ctt 768 Cys Ala Ser His Leu Thr Ala Ile Thr Val Ser His Gly Thr Ile Leu 245 250 255 tac att tat tgc agg ccg agt tca ggc aac agt gga gat gtt gac aaa 816 Tyr Ile Tyr Cys Arg Pro Ser Ser Gly Asn Ser Gly Asp Val Asp Lys 260 265 270 gtg gcc acc gtg ttc tac aca gtt gtg att ccc atg ctg aac ccc ctg 864 Val Ala Thr Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro Leu 275 280 285 atc tac agc ctg aga aat aag gat gtg aac aaa gct ctc aga aaa gtg 912 Ile Tyr Ser Leu Arg Asn Lys Asp Val Asn Lys Ala Leu Arg Lys Val 290 295 300 atg ggc tcc aaa att cac tcc tag 936 Met Gly Ser Lys Ile His Ser 305 310 <210> 364 <211> 311 <212> PRT <213> Homo sapiens <400> 364 Met Gly Lys Glu Asn Cys Thr Thr Val Ala Glu Phe Ile Leu Leu Gly 1 5 10 15 Leu Ser Asp Val Pro Glu Leu Arg Val Cys Leu Phe Leu Leu Phe Leu 20 25 30 Leu Ile Tyr Gly Val Thr Leu Leu Ala Asn Leu Gly Met Thr Ala Leu 35 40 45 Ile Gln Val Ser Ser Arg Leu His Thr Pro Val Tyr Phe Phe Leu Ser 50 55 60 His Leu Ser Phe Val Asp Phe Cys Tyr Ser Ser Ile Ile Val Pro Lys 65 70 75 80 Met Leu Ala Asn Ile Phe Asn Lys Asp Lys Ala Ile Ser Phe Leu Gly 85 90 95 Cys Met Val Gln Phe Tyr Leu Phe Cys Thr Cys Gly Val Thr Glu Val 100 105 110 Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Met Val Thr Met Ser Gln Lys Leu Arg Val Glu Leu 130 135 140 Thr Ser Cys Cys Tyr Phe Cys Gly Thr Val Cys Ser Leu Ile His Ser 145 150 155 160 Ser Leu Ala Leu Arg Ile Leu Phe Tyr Arg Ser Asn Val Ile Asn His 165 170 175 Phe Phe Cys Asp Leu Pro Pro Leu Leu Ser Leu Ala Cys Ser Asp Val 180 185 190 Thr Val Asn Glu Thr Leu Leu Phe Leu Val Ala Thr Leu Asn Glu Ser 195 200 205 Val Thr Ile Met Ile Ile Leu Thr Ser Tyr Leu Leu Ile Leu Thr Thr 210 215 220 Ile Leu Lys Ile His Ser Ala Glu Ser Arg His Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Thr Ala Ile Thr Val Ser His Gly Thr Ile Leu 245 250 255 Tyr Ile Tyr Cys Arg Pro Ser Ser Gly Asn Ser Gly Asp Val Asp Lys 260 265 270 Val Ala Thr Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Asn Lys Ala Leu Arg Lys Val 290 295 300 Met Gly Ser Lys Ile His Ser 305 310 <2 10> 365 <211> 933 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(933) <400> 365 atg gat aaa gaa aac agc tca atg gtg act gag ttt atc ttc atg ggc 48 Met Asp Lys Glu Asn Ser Ser Met Val Thr Glu Phe Ile Phe Met Gly 1 5 10 15 atc acc cag gac cct cag atg gag atc atc ttc ttc gtg gtc ttc ctc 96 Ile Thr Gln Asp Pro Gln Met Glu Ile Ile Phe Phe Val Val Phe Leu 20 25 30 ata gtt tac ctg gtt aat gta gtg ggg aat att ggt atg att atc ctg 144 Ile Val Tyr Leu Val Asn Val Val Gly Asn Ile Gly Met Ile Ile Leu 35 40 45 att aca aca gac act cag ctt cac aca ccc atg tat ttt ttc ctc tgc 192 Ile Thr Thr Asp Thr Gln Leu His Thr Pro Met Tyr Phe Phe Leu Cys 50 55 60 aac ctc tcc ttt gtt gac ctg ggc tac tcc tca gcc att gcc ccc agg 240 Asn Leu Ser Phe Val Asp Leu Gly Tyr Ser Ser Ala Ile Ala Pro Arg 65 70 75 80 atg ctg gct gac ttc cta aca aat cac aaa gtt atc tcc ttc tcc agc 288 Met Leu Ala Asp Phe Leu Thr Asn His Lys Val Ile Ser Phe Ser Ser 85 90 95 tgt gcc acc cag ttt gct ttt ttt gta ggt ttt gtg gat gct gag tgc 336 Cys Ala Thr Gln Phe Ala Phe Phe Val Gly Phe Val Asp Ala Glu Cys 100 105 110 tat gtc ctg gca gcc atg gcc tat ggt cgt ttt gtg gcc att tgt cga 384 Tyr Val Leu Ala Ala Met Ala Tyr Gly Arg Phe Val Ala Ile Cys Arg 115 120 125 ccc ctc cac tat agc acc ttc atg tcc aag cag gtc tgc ttg gct ctc 432 Pro Leu His Tyr Ser Thr Phe Met Ser Lys Gln Val Cys Leu Ala Leu 130 135 140 atg ctg ggc tct tac ctg gct ggt cta gtg agt tta gta gcc cac act 480 Met Leu Gly Ser Tyr Leu Ala Gly Leu Val Ser Leu Val Ala His Thr 145 150 155 160 acc ctc acc ttc agc ctg agt tac tgt ggt tcc aat atc atc aat cat 528 Thr Leu Thr Phe Ser Leu Ser Tyr Cys Gly Ser Asn Ile Ile Asn His 165 170 175 ttc ttc tgc gaa atc cca cca ctc ttg gcc ctc tct tgc tca gac acc 576 Phe Phe Cys Glu Ile Pro Pro Leu Leu Ala Leu Ser Cys Ser Asp Thr 180 185 190 tac atc agt gag atc ttg ctc ttc agt ctg tgt ggc ttc att gaa ttc 624 Tyr Ile Ser Glu Ile Leu Leu Phe Ser Leu Cys Gly Phe Ile Glu Phe 195 200 205 agc acc atc ctc atc atc ttc atc tcc tat acc ttt atc ctt gtt gca 672 Ser Thr Ile Leu Ile Ile Phe Ile Ser Tyr Thr Phe Ile Leu Val Ala 210 215 220 atc atc aga atg cgt tca gct gaa ggc cgc ctt aag gct ttc tcc acc 720 Ile Ile Arg Met Arg Ser Ala Glu Gly Arg Leu Lys Ala Phe Ser Thr 225 230 235 240 tgc ggg tct cac ctt act ggc atc acc ctc ttc tat ggc aca gtc atg 768 Cys Gly Ser His Leu Thr Gly Ile Thr Leu Phe Tyr Gly Thr Val Met 245 250 255 ttt atg tac ctg agg cca aca tcc agc tac tcc ctg gac caa gac aag 816 Phe Met Tyr Leu Arg Pro Thr Ser Ser Tyr Ser Leu Asp Gln Asp Lys 260 265 270 tgg gcc tct gtg ttc tac acg gtt atc atc ccc atg tta aat ccc ttg 864 Trp Ala Ser Val Phe Tyr Thr Val Ile Ile Pro Met Leu Asn Pro Leu 275 280 285 atc tac agt ttg cgg aac aag gat gtg aaa gct gct ttc aaa aag cta 912 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Ala Ala Phe Lys Lys Leu 290 295 300 att gga aaa aaa tct caa taa 933 Ile Gly Lys Lys Ser Gln 305 310 <210> 366 <211> 310 <212> PRT <213> Homo sapiens <400> 366 Met Asp Lys Glu Asn Ser Ser Met Val Thr Glu Phe Ile Phe Met Gly 1 5 10 15 Ile Thr Gln Asp Pro Gln Met Glu Ile Ile Phe Phe Val Val Phe Leu 20 25 30 Ile Val Tyr Leu Val Asn Val Val Gly Asn Ile Gly Met Ile Ile Leu 35 40 45 Ile Thr Thr Asp Thr Gln Leu His Thr Pro Met Tyr Phe Phe Leu Cys 50 55 60 Asn Leu Ser Phe Val Asp Leu Gly Tyr Ser Ser Ala Ile Ala Pro Arg 65 70 75 80 Met Leu Ala Asp Phe Leu Thr Asn His Lys Val Ile Ser Phe Ser Ser 85 90 95 Cys Ala Thr Gln Phe Ala Phe Phe Val Gly Phe Val Asp Ala Glu Cys 100 105 110 Tyr Val Leu Ala Ala Met Ala Tyr Gly Arg Phe Val Ala Ile Cys Arg 115 120 125 Pro Leu His Tyr Ser Thr Phe Met Ser Lys Gln Val Cys Leu Ala Leu 130 135 140 Met Leu Gly Ser Tyr Leu Ala Gly Leu Val Ser Leu Val Ala His Thr 145 150 155 160 Thr Leu Thr Phe Ser Leu Ser Tyr Cys Gly Ser Asn Ile Ile Asn His 165 170 175 Phe Phe Cys Glu Ile Pro Pro Leu Leu Ala Leu Ser Cys Ser Asp Thr 180 185 190 Tyr Ile Ser Glu Ile Leu Leu Phe Ser Leu Cys Gly Phe Ile Glu Phe 195 200 205 Ser Thr Ile Leu Ile Ile Phe Ile Ser Tyr Thr Phe Ile Leu Val Ala 210 215 220 Ile Ile Arg Met Arg Ser Ala Glu Gly Arg Leu Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Thr Gly Ile Thr Leu Phe Tyr Gly Thr Val Met 245 250 255 Phe Met Tyr Leu Arg Pro Thr Ser Ser Tyr Ser Leu Asp Gln Asp Lys 260 265 270 Trp Ala Ser Val Phe Tyr Thr Val Ile Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Ala Ala Phe Lys Lys Leu 290 295 300 Ile Gly Lys Lys Ser Gln 305 310 <210> 367 <211> 948 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(948) <400> 367 atg ttc tcc cca aac cac acc ata gtg aca gaa ttc att ctc ttg gga 48 Met Phe Ser Pro Asn His Thr Ile Val Thr Glu Phe Ile Leu Leu Gly 1 5 10 15 ctg aca gac gac cca gtg cta gag aag atc ctg ttt ggg gta ttc ctt 96 Leu Thr Asp Asp Pro Val Leu Glu Lys Ile Leu Phe Gly Val Phe Leu 20 25 30 gcg atc tac cta atc aca ctg gca ggc aac ctg tgc atg atc ctg ctg 144 Ala Ile Tyr Leu Ile Thr Leu Ala Gly Asn Leu Cys Met Ile Leu Leu 35 40 45 atc agg acc aat tcc cac ctg caa aca ccc atg tat ttc ttc ctt ggc 192 Ile Arg Thr Asn Ser His Leu Gln Thr Pro Met Tyr Phe Phe Leu Gly 50 55 60 cac ctc tcc ttt gta gac att tgc tat tct tcc aat gtt act cca aat 240 His Leu Ser Phe Val Asp Ile Cys Tyr Ser Ser Asn Val Thr Pro Asn 65 70 75 80 atg ctg cac aat ttc ctc tca gaa cag aag acc atc tcc tac gct gga 288 Met Leu His Asn Phe Leu Ser Glu Gln Lys Thr Ile Ser Tyr Ala Gly 85 90 95 tgc ttc aca cag tgt ctt ctc ttc atc gcc ctg gtg atc act gag ttt 336 Cys Phe Thr Gln Cys Leu Leu Phe Ile Ala Leu Val Ile Thr Glu Phe 100 105 110 tac atc ctt gct tca atg gca ttg gat cgc tat gta gcc att tgc agc 384 Tyr Ile Leu Ala Ser Met Ala Leu Asp Arg Tyr Val Ala Ile Cys Ser 115 120 125 cct ttg cat tac agt tcc agg atg tcc aag aac atc tgt gtc tgt ctg 432 Pro Leu His Tyr Ser Ser Arg Met Ser Lys Asn Ile Cys Val Cys Leu 130 135 140 gtc act atc cct tac atg tat ggg ttt ctt agt ggg ttc tct cag tca 480 Val Thr Ile Pro Tyr Met Tyr Gly Phe Leu Ser Gly Phe Ser Gln Ser 145 150 155 160 ctg cta acc ttt cac tta tcc ttc tgt ggc tcc ctt gaa atc aat cat 528 Leu Leu Thr Phe His Leu Ser Phe Cys Gly Ser Leu Glu Ile Asn His 165 170 175 ttc tac tgc gct gat cct cct ctt atc atg ctg gcc tgc tct gac acc 576 Phe Tyr Cys Ala Asp Pro Pro Leu Ile Met Leu Ala Cys Ser Asp Thr 180 185 190 cgt gtc aaa aag atg gca atg ttt gta gtt gca ggc ttt aat ctc tca 624 Arg Val Lys Lys Met Ala Met Phe Val Val Ala Gly Phe Asn Leu Ser 195 200 205 agc tct ctc ttc atc att ctt ctg tcc tat ctt ttc att ttt gca gcg 672 Ser Ser Leu Phe Ile Ile Leu Leu Ser Tyr Leu Phe Ile Phe Ala Ala 210 215 220 atc ttc agg atc cgt tct gct gaa ggc agg cac aaa gcc ttt tct acg 720 Ile Phe Arg Ile Arg Ser Ala Glu Gly Arg His Lys Ala Phe Ser Thr 225 230 235 240 tgt gct tcc cac ctg aca ata gtc act ttg ttt tat gga acc ctc ttc 768 Cys Ala Ser His Leu Thr Ile Val Thr Leu Phe Tyr Gly Thr Leu Phe 245 250 255 tgc atg tac gta agg cct cca tca gag aag tct gta gag gag tcc aaa 816 Cys Met Tyr Val Arg Pro Pro Ser Glu Lys Ser Val Glu Glu Ser Lys 260 265 270 ata act gca gtc ttt tat act ttt ttg agc cca atg ctg aac cca ttg 864 Ile Thr Ala Val Phe Tyr Thr Phe Leu Ser Pro Met Leu Asn Pro Leu 275 280 285 atc tat agc cta cgg aac aca gat gta atc ctt gcc atg caa caa atg 912 Ile Tyr Ser Leu Arg Asn Thr Asp Val Ile Leu Ala Met Gln Gln Met 290 295 300 att agg gga aaa tcc ttt cat aaa att gca gtt tag 948 Ile Arg Gly Lys Ser Phe His Lys Ile Ala Val 305 310 315 <210> 368 <211> 315 <212> PRT <213> Homo sapiens <400> 368 Met Phe Ser Pro Asn His Thr Ile Val Thr Glu Phe Ile Leu Leu Gly 1 5 10 15 Leu Thr Asp Asp Pro Val Leu Glu Lys Ile Leu Phe Gly Val Phe Leu 20 25 30 Ala Ile Tyr Leu Ile Thr Leu Ala Gly Asn Leu Cys Met Ile Leu Leu 35 40 45 Ile Arg Thr Asn Ser His Leu Gln Thr Pro Met Tyr Phe Phe Leu Gly 50 55 60 His Leu Ser Phe Val Asp Ile Cys Tyr Ser Ser Asn Val Thr Pro Asn 65 70 75 80 Met Leu His Asn Phe Leu Ser Glu Gln Lys Thr Ile Ser Tyr Ala Gly 85 90 95 Cys Phe Thr Gln Cys Leu Leu Phe Ile Ala Leu Val Ile Thr Glu Phe 100 105 110 Tyr Ile Leu Ala Ser Met Ala Leu Asp Arg Tyr Val Ala Ile Cys Ser 115 120 125 Pro Leu His Tyr Ser Ser Arg Met Ser Lys Asn Ile Cys Val Cys Leu 130 135 140 Val Thr Ile Pro Tyr Met Tyr Gly Phe Leu Ser Gly Phe Ser Gln Ser 145 150 155 160 Leu Leu Thr Phe His Leu Ser Phe Cys Gly Ser Leu Glu Ile Asn His 165 170 175 Phe Tyr Cys Ala Asp Pro Pro Leu Ile Met Leu Ala Cys Ser Asp Thr 180 185 190 Arg Val Lys Lys Met Ala Met Phe Val Val Ala Gly Phe Asn Leu Ser 195 200 205 Ser Ser Leu Phe Ile Ile Leu Leu Ser Tyr Leu Phe Ile Phe Ala Ala 210 215 220 Ile Phe Arg Ile Arg Ser Ala Glu Gly Arg His Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Thr Ile Val Thr Leu Phe Tyr Gly Thr Leu Phe 245 250 255 Cys Met Tyr Val Arg Pro Pro Ser Glu Lys Ser Val Glu Glu Ser Lys 260 265 270 Ile Thr Ala Val Phe Tyr Thr Phe Leu Ser Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Thr Asp Val Ile Leu Ala Met Gln Gln Met 290 295 300 Ile Arg Gly Lys Ser Phe His Lys Ile Ala Val 305 310 315 <210> 369 <211> 918 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(918) <400> 369 atg cag agg agc aat cac aca gtg act gag ttt ata ctg ctg ggc ttc 48 Met Gln Arg Ser Asn His Thr Val Thr Glu Phe Ile Leu Leu Gly Phe 1 5 10 15 acc aca gac cca ggg atg cag ctg ggc ctc ttc gtg gtg ttc ctg ggc 96 Thr Thr Asp Pro Gly Met Gln Leu Gly Leu Phe Val Val Phe Leu Gly 20 25 30 gtg tac tct ctc act gtg gta gga aat agc acc ctc atc gtg ttg atc 144 Val Tyr Ser Leu Thr Val Val Gly Asn Ser Thr Leu Ile Val Leu Ile 35 40 45 tgt aat gac tcc cac ctc cac aca ccc atg tat ttt gtc gtt gga aat 192 Cys Asn Asp Ser His Leu His Thr Pro Met Tyr Phe Val Val Gly Asn 50 55 60 ctg tcg ttt ctg gat ctc tgg tat tct tct gtc tac acc cca aag atc 240 Leu Ser Phe Leu Asp Leu Trp Tyr Ser Ser Val Tyr Thr Pro Lys Ile 65 70 75 80 cta gtg atc tgc atc tct gaa gac aaa agc atc tcc ttt gct ggc tgc 288 Leu Val Ile Cys Ile Ser Glu Asp Lys Ser Ile Ser Phe Ala Gly Cys 85 90 95 ctg tgt cag ttc ttc ttc tct gca ggg ctg gcc tat agt gag tgc tgc 336 Leu Cys Gln Phe Phe Phe Ser Ala Gly Leu Ala Tyr Ser Glu Cys Cys 100 105 110 tta ctg gct gcc atg gct tat gac cgc tac gtg gcc atc tcc aag ccc 384 Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Ser Lys Pro 115 120 125 ctg ctt tat gcc cag gcc atg tcc ata aag ctg tgt gca ttg ctg gta 432 Leu Leu Tyr Ala Gln Ala Met Ser Ile Lys Leu Cys Ala Leu Leu Val 130 135 140 gca gtc tca tat tgt ggt ggc ttt att aac tct tca atc atc acc aag 480 Ala Val Ser Tyr Cys Gly Gly Phe Ile Asn Ser Ser Ile Ile Thr Lys 145 150 155 160 aaa acg ttt tcc ttt aac ttc tgc cgt gaa aac atc att gat gac ttt 528 Lys Thr Phe Ser Phe Asn Phe Cys Arg Glu Asn Ile Ile Asp Asp Phe 165 170 175 ttc tgt gat ttg ctt ccc ttg gtg gag ctg gcc tgt ggc gag aag ggc 576 Phe Cys Asp Leu Leu Pro Leu Val Glu Leu Ala Cys Gly Glu Lys Gly 180 185 190 ggc tat aaa att atg atg tac ttc ctg ctg gcc tcc aat gtc atc tgc 624 Gly Tyr Lys Ile Met Met Tyr Phe Leu Leu Ala Ser Asn Val Ile Cys 195 200 205 ccc gca gtg ctc atc ctg gcc tcc tac ctc ttt atc atc acc agt gtc 672 Pr o Ala Val Leu Ile Leu Ala Ser Tyr Leu Phe Ile Ile Thr Ser Val 210 215 220 ttg agg atc tcc tcc tcc aag ggc tac ctc aaa gcc ttc tcc aca tgc 720 Leu Arg Ile Ser Ser Ser Lys Gly Tyr Leu Lys Ala Phe Ser Thr Cys 225 230 235 240 tcc tcc cac ctg acc tct gtc act tta tac tat ggc tcc att ctc tac 768 Ser Ser His Leu Thr Ser Val Thr Leu Tyr Tyr Gly Ser Ile Leu Tyr 245 250 255 atc tac gct ctc ccc aga tct agc tat tct ttt gat atg gac aaa ata 816 Ile Tyr Ala Leu Pro Arg Ser Ser Tyr Ser Phe Asp Met Asp Lys Ile 260 265 270 gtt tct aca ttt tac act gtg gta ttc ccc atg ttg aat ctc atg atc 864 Val Ser Thr Phe Tyr Thr Val Val Phe Pro Met Leu Asn Leu Met Ile 275 280 285 tac agc cta agg aat aag gat gtg aaa gag gct ctg aaa aaa ctt ctc 912 Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu Ala Leu Lys Lys Leu Leu 290 295 300 cca taa 918 Pro 305 <210> 370 <211> 305 <212> PRT <213> Homo sapiens <400> 370 Met Gln Arg Ser Asn His Thr Val Thr Glu Phe Ile Leu Leu Gly Phe 1 5 10 15 Thr Thr Asp Pro Gly Met Gln Leu Gly Leu Phe Val Val Phe Leu Gly 20 25 30 Val Tyr Ser Leu Thr Val Val Gly Asn Ser Thr Leu Ile Val Leu Ile 35 40 45 Cys Asn Asp Ser His Leu His Thr Pro Met Tyr Phe Val Val Gly Asn 50 55 60 Leu Ser Phe Leu Asp Leu Trp Tyr Ser Ser Val Tyr Thr Pro Lys Ile 65 70 75 80 Leu Val Ile Cys Ile Ser Glu Asp Lys Ser Ile Ser Phe Ala Gly Cys 85 90 95 Leu Cys Gln Phe Phe Phe Ser Ala Gly Leu Ala Tyr Ser Glu Cys Cys 100 105 110 Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Ser Lys Pro 115 120 125 Leu Leu Tyr Ala Gln Ala Met Ser Ile Lys Leu Cys Ala Leu Leu Val 130 135 140 Ala Val Ser Tyr Cys Gly Gly Phe Ile Asn Ser Ser Ile Ile Thr Lys 145 150 155 160 Lys Thr Phe Ser Phe Asn Phe Cys Arg Glu Asn Ile Ile Asp Asp Phe 165 170 175 Phe Cys Asp Leu Leu Pro Leu Val Glu Leu Ala Cys Gly Glu Lys Gly 180 185 190 Gly Tyr Lys Ile Met Met Tyr Phe Leu Leu Ala Ser Asn Val Ile Cys 195 200 205 Pro Ala Val Leu Ile Leu Ala Ser Tyr Leu Phe Ile Ile Thr Ser Val 210 215 220 Leu Arg Ile Ser Ser Ser Lys Gly Tyr Leu Lys Ala Phe Ser Thr Cys 225 230 235 240 Ser Ser His Leu Thr Ser Val Thr Leu Tyr Tyr Gly Ser Ile Leu Tyr 245 250 255 Ile Tyr Ala Leu Pro Arg Ser Ser Tyr Ser Phe Asp Met Asp Lys Ile 260 265 270 Val Ser Thr Phe Tyr Thr Val Val Phe Pro Met Leu Asn Leu Met Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu Ala Leu Lys Lys Leu Leu 290 295 300 Pro 305 <210> 371 <211> 954 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(954) <400> 371 atg atg aga ctt atg aaa gag gtt cga ggc aga aat caa aca gaa gta 48 Met Met Arg Leu Met Lys Glu Val Arg Gly Arg Asn Gln Thr Glu Val 1 5 10 15 aca gaa ttt ctc ctc tta gga ctt tcc gac aat cca gat cta caa gga 96 Thr Glu Phe Leu Leu Leu Gly Leu Ser Asp Asn Pro Asp Leu Gln Gly 20 25 30 gtc ctc ttt gca ttg ttt ctg ttg atc tat atg gca aac atg gtg ggc 144 Val Leu Phe Ala Leu Phe Leu Leu Ile Tyr Met Ala Asn Met Val Gly 35 40 45 aat ttg ggg atg att gta ttg att aag att gat ctc tgt ctc cac acc 192 Asn Leu Gly Met Ile Val Leu Ile Lys Ile Asp Leu Cys Leu His Thr 50 55 60 ccc atg tat ttc ttt ctc agt agc ctc tct ttt gta gat gcc tct tac 240 Pro Met Tyr Phe Phe Leu Ser Ser Leu Ser Phe Val Asp Ala Ser Tyr 65 70 75 80 tct tct tcc gtc act ccc aag atg ctg gtg aac ctc atg gct gag aat 288 Ser Ser Ser Val Thr Pro Lys Met Leu Val Asn Leu Met Ala Glu Asn 85 90 95 aag gcc att tct ttt cat gga tgt gct gcc cag ttc tac ttc ttt ggc 336 Lys Ala Ile Ser Phe His Gly Cys Ala Ala Gln Phe Tyr Phe Phe Gly 100 105 110 tcc ttc ctg ggg act gag tgc ttc ctg ttg gcc atg atg gca tat gac 384 Ser Phe Leu Gly Thr Glu Cys Phe Leu Leu Ala Met Met Ala Tyr Asp 115 120 125 cgc tat gca gcc att tgg aac ccc ctg ctc tac cca gtt ctc gtg tct 432 Arg Tyr Ala Ala Ile Trp Asn Pro Leu Leu Tyr Pro Val Leu Val Ser 130 135 140 ggg aga att tgc ttt ttg cta ata gct acc tcc ttc tta gca ggt tgt 480 Gly Arg Ile Cys Phe Leu Leu Ile Ala Thr Ser Phe Leu Ala Gly Cys 145 150 155 160 gga aat gca gcc ata cat aca ggg atg act ttt agg ttg tcc ttt tgt 528 Gly Asn Ala Ala Ile His Thr Gly Met Thr Phe Arg Leu Ser Phe Cys 165 170 175 ggt tct aat agg atc aac cat ttc tac tgt gac acc ccg cca ctg ctc 576 Gly Ser Asn Arg Ile Asn His Phe Tyr Cys Asp Thr Pro Pro Leu Leu 180 185 190 aaa ctc tct tgc tct gat acc cac ttc aat ggc att gtg atc atg gca 624 Lys Leu Ser Cys Ser Asp Thr His Phe Asn Gly Ile Val Ile Met Ala 195 200 205 ttc tca agt ttt att gtc atc agc tgt gtt atg att gtc ctc att tcc 672 Phe Ser Ser Phe Ile Val Ile Ser Cys Val Met Ile Val Leu Ile Ser 210 215 220 tac ctg tgt atc ttc att gcc gtc ttg aag atg cct tcg tta gag ggc 720 Tyr Leu Cys Ile Phe Ile Ala Val Leu Lys Met Pro Ser Leu Glu Gly 225 230 235 240 agg cac aaa gcc ttc tcc acc tgt gcc tct tac ctc atg gct gtc acc 768 Arg His Lys Ala Phe Ser Thr Cys Ala Ser Tyr Leu Met Ala Val Thr 245 250 255 ata ttc ttt gga aca atc ctc ttc atg tac ttg cgc cct aca tct agc 816 Ile Phe Phe Gly Thr Ile Leu Phe Met Tyr Leu Arg Pro Thr Ser Ser 260 265 270 tac tca atg gag caa gac aag gtt gtc tct gtc ttt tat aca gta ata 864 Tyr Ser Met Glu Gln Asp Lys Val Val Ser Val Phe Tyr Thr Val Ile 275 280 285 atc cct gtg cta aat ccc ctc atc tat agt tta aaa aat aag gat gta 912 Ile Pro Val Leu Asn Pro Leu Ile Tyr Ser Leu Lys Asn Lys Asp Val 290 295 300 aaa aag gcc cta aag aag atc tta tgg aaa cac atc ttg tag 954 Lys Lys Ala Leu Lys Lys Ile Leu Trp Lys His Ile Leu 305 310 315 <210> 372 <211> 317 <212> PRT <213> Homo sapiens <400> 372 Met Met Arg Leu Met Lys Glu Val Arg Gly Arg Asn Gln Thr Glu Val 1 5 10 15 Thr Glu Phe Leu Leu Leu Gly Leu Ser Asp Asn Pro Asp Leu Gln Gly 20 25 30 Val Leu Phe Ala Leu Phe Leu Leu Ile Tyr Met Ala Asn Met Val Gly 35 40 45 Asn Leu Gly Met Ile Val Leu Ile Lys Ile Asp Leu Cys Leu His Thr 50 55 60 Pro Met Tyr Phe Phe Leu Ser Ser Leu Ser Phe Val Asp Ala Ser Tyr 65 70 75 80 Ser Ser Ser Val Thr Pro Lys Met Leu Val Asn Leu Met Ala Glu Asn 85 90 95 Lys Ala Ile Ser Phe His Gly Cys Ala Ala Gln Phe Tyr Phe Phe Gly 100 105 110 Ser Phe Leu Gly Thr Glu Cys Phe Leu Leu Ala Met Met Ala Tyr Asp 115 120 125 Arg Tyr Ala Ala Ile Trp Asn Pro Leu Leu Tyr Pro Val Leu Val Ser 130 135 140 Gly Arg Ile Cys Phe Leu Leu Ile Ala Thr Ser Phe Leu Ala Gly Cys 145 150 155 160 Gly Asn Ala Ala Ile His Thr Gly Met Thr Phe Arg Leu Ser Phe Cys 165 170 175 Gly Ser Asn Arg Ile Asn His Phe Tyr Cys Asp Thr Pro Pro Leu Leu 180 185 190 Lys Leu Ser Cys Ser Asp Thr His Phe Asn Gly Ile Val Ile Met Ala 195 200 205 Phe Ser Ser Phe Ile Val Ile Ser Cys Val Met Ile Val Leu Ile Ser 210 215 220 Tyr Leu Cys Ile Phe Ile Ala Val Leu Lys Met Pro Ser Leu Glu Gly 225 230 235 240 Arg His Lys Ala Phe Ser Thr Cys Ala Ser Tyr Leu Met Ala Val Thr 245 250 255 I le Phe Phe Gly Thr Ile Leu Phe Met Tyr Leu Arg Pro Thr Ser Ser 260 265 270 Tyr Ser Met Glu Gln Asp Lys Val Val Ser Val Phe Tyr Thr Val Ile 275 280 285 Ile Pro Val Leu Asn Pro Leu Ile Tyr Ser Leu Lys Asn Lys Asp Val 290 295 300 Lys Lys Ala Leu Lys Lys Ile Leu Trp Lys His Ile Leu 305 310 315 <210> 373 <211> 939 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(939) <400> 373 atg aat gga atg aat cac tct gtg gta tca gaa ttt gta ttc atg gga 48 Met Asn Gly Met Asn His Ser Val Val Ser Glu Phe Val Phe Met Gly 1 5 10 15 ctc acc aac tca cgg gag att cag ctt cta ctt ttt gtt ttc tct ttg 96 Leu Thr Asn Ser Arg Glu Ile Gln Leu Leu Leu Phe Val Phe Ser Leu 20 25 30 ttg ttc tac ttt gcg agc atg atg gga aac ctt gtc att gta ttc act 144 Leu Phe Tyr Phe Ala Ser Met Met Gly Asn Leu Val Ile Val Phe Thr 35 40 45 gta acc atg gat gct cat ctg cac tcc ccc atg tat ttc ctc ctg gct 192 Val Thr Met Asp Ala His Leu His Ser Pro Met Tyr Phe Leu Leu Ala 50 55 60 aac ctc tca atc att gat atg gca ttt tgc tca att aca gcc cct aag 240 Asn Leu Ser Ile Ile Asp Met Ala Phe Cys Ser Ile Thr Ala Pro Lys 65 70 75 80 atg att tgt gat att ttc aag aag cac aag gcc atc tcc ttt cgg gga 288 Met Ile Cys Asp Ile Phe Lys Lys His Lys Ala Ile Ser Phe Arg Gly 85 90 95 tgt att act cag atc ttc ttt agc cat gct ctt ggg ggc act gag atg 336 Cys Ile Thr Gln Ile Phe Phe Ser His Ala Leu Gly Gly Thr Glu Met 100 105 110 gtg ctg ctc ata gcc atg gcc ttt gac aga tac atg gcc ata tgt aaa 384 Val Leu Leu Ile Ala Met Ala Phe Asp Arg Tyr Met Ala Ile Cys Lys 115 120 125 cct ctc cac tac ctg acc atc atg agc cca aga atg tgt cta tac ttt 432 Pro Leu His Tyr Leu Thr Ile Met Ser Pro Arg Met Cys Leu Tyr Phe 130 135 140 tta gcc act tcc tct atc att ggc ctt atc cac tca ttg gtc caa tta 480 Leu Ala Thr Ser Ser Ile Ile Gly Leu Ile His Ser Leu Val Gln Leu 145 150 155 160 gtt ttt gtg gta gat tta cct ttt tgt ggt cct aat atc ttt gac agt 528 Val Phe Val Val Asp Leu Pro Phe Cys Gly Pro Asn Ile Phe Asp Ser 165 170 175 ttt tac tgt gat ctc cct cgg ctc ctc aga ctt gcc tgt acc aac acc 576 Phe Tyr Cys Asp Leu Pro Arg Leu Leu Arg Leu Ala Cys Thr Asn Thr 180 185 190 caa gaa ctg gag ttc atg gtc act gtc aat agt gga ctc att tct gtg 624 Gln Glu Leu Glu Phe Met Val Thr Val Asn Ser Gly Leu Ile Ser Val 195 200 205 ggc tcc ttt gtc ttg ctg gta att tcc tac atc ttc att ctg ttc act 672 Gly Ser Phe Val Leu Leu Val Ile Ser Tyr Ile Phe Ile Leu Phe Thr 210 215 220 gtt tgg aaa cat tct tct ggt ggt cta gcc aag gcc ctc tct acc ctg 720 Val Trp Lys His Ser Ser Gly Gly Leu Ala Lys Ala Leu Ser Thr Leu 225 230 235 240 tca gct cat gtc act gtg gtc atc ttg ttc ttt ggg cca ctg atg ttt 768 Ser Ala His Val Thr Val Val Ile Leu Phe Phe Gly Pro Leu Met Phe 245 250 255 ttc tac aca tgg cct tct ccc aca tca cac ctg gat aaa tat ctt gct 816 Phe Tyr Thr Trp Pro Ser Pro Thr Ser His Leu Asp Lys Tyr Leu Ala 260 265 270 att ttt gat gca ttt att act cct ttt ctg aat cca gtt atc tac aca 864 Ile Phe Asp Ala Phe Ile Thr Pro Phe Leu Asn Pro Val Ile Tyr Thr 275 280 285 ttc agg aac aaa gac atg aaa gtg gca atg agg aga ctg tgc agt cgt 912 Phe Arg Asn Lys Asp Met Lys Val Ala Met Arg Arg Leu Cys Ser Arg 290 295 300 ctt gcg cat ttt aca aag att ttg taa 939 Leu Ala His Phe Thr Lys Ile Leu 305 310 <210> 374 <211> 312 <212> PRT <213> Homo sapiens <400> 374 Met Asn Gly Met Asn His Ser Val Val Ser Glu Phe Val Phe Met Gly 1 5 10 15 Leu Thr Asn Ser Arg Glu Ile Gln Leu Leu Leu Phe Val Phe Ser Leu 20 25 30 Leu Phe Tyr Phe Ala Ser Met Met Gly Asn Leu Val Ile Val Phe Thr 35 40 45 Val Thr Met Asp Ala His Leu His Ser Pro Met Tyr Phe Leu Leu Ala 50 55 60 Asn Leu Ser Ile Ile Asp Met Ala Phe Cys Ser Ile Thr Ala Pro Lys 65 70 75 80 Met Ile Cys Asp Ile Phe Lys Lys His Lys Ala Ile Ser Phe Arg Gly 85 90 95 Cys Ile Thr Gln Ile Phe Phe Ser His Ala Leu Gly Gly Thr Glu Met 100 105 110 Val Leu Leu Ile Ala Met Ala Phe Asp Arg Tyr Met Ala Ile Cys Lys 115 120 125 Pro Leu His Tyr Leu Thr Ile Met Ser Pro Arg Met Cys Leu Tyr Phe 130 135 140 Leu Ala Thr Ser Ser Ile Ile Gly Leu Ile His Ser Leu Val Gln Leu 145 150 155 160 Val Phe Val Val Asp Leu Pro Phe Cys Gly Pro Asn Ile Phe Asp Ser 165 170 175 Phe Tyr Cys Asp Leu Pro Arg Leu Leu Arg Leu Ala Cys Thr Asn Thr 180 185 190 Gln Glu Leu Glu Phe Met Val Thr Val Asn Ser Gly Leu Ile Ser Val 195 200 205 Gly Ser Phe Val Leu Leu Val Ile Ser Tyr Ile Phe Ile Leu Phe Thr 210 215 220 Val Trp Lys His Ser Ser Gly Gly Leu Ala Lys Ala Leu Ser Thr Leu 225 230 235 240 Ser Ala His Val Thr Val Val Ile Leu Phe Phe Gly Pro Leu Met Phe 245 250 255 Phe Tyr Thr Trp Pro Ser Pro Thr Ser His Leu Asp Lys Tyr Leu Ala 260 265 270 Ile Phe Asp Ala Phe Ile Thr Pro Phe Leu Asn Pro Val Ile Tyr Thr 275 280 285 Phe Arg Asn Lys Asp Met Lys Val Ala Met Arg Arg Leu Cys Ser Arg 290 295 300 Leu Ala His Phe Thr Lys Ile Leu 305 310 <210> 375 <211> 876 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(876) <400> 375 atg gtt ggg gca aat cac tcc gtg gtg tca gag ttt gtg ttc ctg gga 48 Met Val Gly Ala Asn His Ser Val Val Ser Glu Phe Val Phe Leu Gly 1 5 10 15 ctc acc aat tcc tgg gag atc cga ctt ctc ctc ctt gtg ttc tcc tcc 96 Leu Thr Asn Ser Trp Glu Ile Arg Leu Leu Leu Leu Val Phe Ser Ser 20 25 30 atg ttt tac atg gcc agt atg atg gga aac tct ctc att ttg ctc act 144 Met Phe Tyr Met Ala Ser Met Met Gly Asn Ser Leu Ile Leu Leu Thr 35 40 45 gtg act tct gac cct cac ttg cac tcc ccc atg tat ttt ctg tta gcc 192 Val Thr Ser Asp Pro His Leu His Ser Pro Met Tyr Phe Leu Leu Ala 50 55 60 aac ctc tcc ttc att gac ctg ggt gtt tcc tct gtc act tct ccc aaa 240 Asn Leu Ser Phe Ile Asp Leu Gly Val Ser Ser Val Thr Ser Pro Lys 65 70 75 80 atg att tat gac ctg ttc aga aag cac gaa gtc atc tcc ttt gga ggc 288 Met Ile Tyr Asp Leu Phe Arg Lys His Glu Val Ile Ser Phe Gly Gly 85 90 95 tgc atc gct caa atc ttc ttc atc cac gtc att ggc ggt gtg gag atg 336 Cys Ile Ala Gln Ile Phe Phe Ile His Val Ile Gly Gly Val Glu Met 100 105 110 gtg ctg ctc ata gcc atg gcc ttt gac aga tat gtg gcc ata tgt aag 384 Val Leu Leu Ile Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Lys 115 120 125 ccc ctc cag tac ctg acc att atg agc cca aga atg tgc atg ttc ttc 432 Pro Leu Gln Tyr Leu Thr Ile Met Ser Pro Arg Met Cys Met Phe Phe 130 135 140 tta gtg gct gcc tgg gtg acc ggc ctt atc cac tct gta gtt caa ttg 480 Leu Val Ala Ala Trp Val Thr Gly Leu Ile His Ser Val Val Gln Leu 145 150 155 160 gtt ttt gta gta aac ttg ccc ttc tgt ggt cct aat gta tcg gac agc 528 Val Phe Val Val Asn Leu Pro Phe Cys Gly Pro Asn Val Ser Asp Ser 165 170 175 ttt tac tgt gac ctt cct cgg ttc atc aaa ctt gcc tgc aca gac agc 576 Phe Tyr Cys Asp Leu Pro Arg Phe Ile Lys Leu Ala Cys Thr Asp Ser 180 185 190 tac cga ctg gag ttc atg gtt aca gcc aac agt gga ttc atc tct ctg 624 Tyr Arg Leu Glu Phe Met Val Thr Ala Asn Ser Gly Phe Ile Ser Leu 195 200 205 ggc tcc ttc ttc ata ctg atc att tcc tat gtg gtc atc att ctc act 672 Gly Ser Phe Phe Ile Leu Ile Ile Ser Tyr Val Val Ile Ile Leu Thr 210 215 220 gtt ctg aaa cac tct tca gct ggt tta tcc aag gct ctg tcc acc ctt 720 Val Leu Lys His Ser Ser Ala Gly Leu Ser Lys Ala Leu Ser Thr Leu 225 230 235 240 tca gct cac gtc agt gtg gta gtt ttg ttc ttt ggt cct ttg att ttt 768 Ser Ala His Val Ser Val Val Val Leu Phe Phe Gly Pro Leu Ile Phe 245 250 255 gtc tat acg tgg cca tct ccc tcc aca cac ctg gat aag ttt ctg gcc 816 Val Tyr Thr Trp Pro Ser Pro Ser Thr His Leu Asp Lys Phe Leu Ala 260 265 270 atc ttt gat gca gtt ctc act cct gtt tta aat cct atc atc tac aca 864 Ile Phe Asp Ala Val Leu Thr Pro Val Leu Asn Pro Ile Ile Tyr Thr 275 280 285 ttc agg aat tga 876 Phe Arg Asn 290 <210> 376 <211> 291 <212> PRT <213> Homo sapiens <400> 376 Met Val Gly Ala Asn His Ser Val Val Ser Glu Phe Val Phe Leu Gly 1 5 10 15 Leu Thr Asn Ser Trp Glu Ile Arg Leu Leu Leu Leu Val Phe Ser Ser 20 25 30 Met Phe Tyr Met Ala Ser Met Met Gly Asn Ser Leu Ile Leu Leu Thr 35 40 45 Val Thr Ser Asp Pro His Leu His Ser Pro Met Tyr Phe Leu Leu Ala 50 55 60 Asn Leu Ser Phe Ile Asp Leu Gly Val Ser Ser Val Thr Ser Pro Lys 65 70 75 80 Met Ile Tyr Asp Leu Phe Arg Lys His Glu Val Ile Ser Phe Gly Gly 85 90 95 Cys Ile Ala Gln Ile Phe Phe Ile His Val Ile Gly Gly Val Glu Met 100 105 110 Val Leu Leu Ile Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Lys 115 120 125 Pro Leu Gln Tyr Leu Thr Ile Met Ser Pro Arg Met Cys Met Phe Phe 130 135 140 Leu Val Ala Ala Trp Val Thr Gly Leu Ile His Ser Val Val Gln Leu 145 150 155 160 Val Phe Val Val Asn Leu Pro Phe Cys Gly Pro Asn Val Ser Asp Ser 165 170 175 Phe Tyr Cys Asp Leu Pro Arg Phe Ile Lys Leu Ala Cys Thr Asp Ser 180 185 190 Tyr Arg Leu Glu Phe Met Val Thr Ala Asn Ser Gly Phe Ile Ser Leu 195 200 205 Gly Ser Phe Phe Ile Leu Ile Ile Ser Tyr Val Val Ile Ile Leu Thr 210 215 220 Val Leu Lys His Ser Ser Ala Gly Leu Ser Lys Ala Leu Ser Thr Leu 225 230 235 240 Ser Ala His Val Ser Val Val Val Leu Phe Phe Gly Pro Leu Ile Phe 245 250 255 Val Tyr Thr Trp Pro Ser Pro Ser Thr His Leu Asp Lys Phe Leu Ala 260 265 270 Ile Phe Asp Ala Val Leu Thr Pro Val Leu Asn Pro Ile Ile Tyr Thr 275 280 285 Phe Arg Asn 290 <210> 377 <211> 1239 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1239) <400> 377 atg aat gag aac atg cag tgt ttt gtt ttc tgt tct tgt gat agt ttg 48 Met Asn Glu Asn Met Gln Cys Phe Val Phe Cys Ser Cys Asp Ser Leu 1 5 10 15 ctg aga atg atg gtt tcc cgc ttc atc cat gtc cca ttt gta aaa atg 96 Leu Arg Met Met Val Ser Arg Phe Ile His Val Pro Phe Val Lys Met 20 25 30 aaa agg ata att gtg gga gga tat tct aaa cac ttc ttt tct aat gag 144 Lys Arg Ile Ile Val Gly Gly Tyr Ser Lys His Phe Phe Ser Asn Glu 35 40 45 ctg ctc tgt gtg agg ccc tgg tca ggg aaa acg tgg tcg ata agg cat 192 Leu Leu Cys Val Arg Pro Trp Ser Gly Lys Thr Trp Ser Ile Arg His 50 55 60 cac att ttt gac atg gag ctt ctg aca aat aat ctc aaa ttt atc act 240 His Ile Phe Asp Met Glu Leu Leu Thr Asn Asn Leu Lys Phe Ile Thr 65 70 75 80 gac cct ttt gtt tgt agg ctc cga cac ctg agt cca aca cct tca gaa 288 Asp Pro Phe Val Cys Arg Leu Arg His Leu Ser Pro Thr Pro Ser Glu 85 90 95 gaa cac atg aaa aat aag aac aat gtg act gaa ttt atc ctc tta ggg 336 Glu His Met Lys Asn Lys Asn Asn Val Thr Glu Phe Ile Leu Leu Gly 100 105 110 ctc aca cag aac cct gag ggg caa aag gtt tta ttt gtc aca ttc tta 384 Leu Thr Gln Asn Pro Glu Gly Gln Lys Val Leu Phe Val Thr Phe Leu 115 120 125 cta atc tac atg gtg acg ata atg ggc aac ctg ctt atc ata gtg acc 432 Leu Ile Tyr Met Val Thr Ile Met Gly Asn Leu Leu Ile Ile Val Thr 130 135 140 atc atg gcc agc cag tcc ctg ggt tcc ccc atg tac ttt ttt ctg gct 480 Ile Met Ala Ser Gln Ser Leu Gly Ser Pro Met Tyr Phe Phe Leu Ala 145 150 155 160 tct tta tca ttc ata gat acc gtc tat tct act gca ttt gct ccc aaa 528 Ser Leu Ser Phe Ile Asp Thr Val Tyr Ser Thr Ala Phe Ala Pro Lys 165 170 175 atg att gtt gac ttg ctc tct gag aaa aag acc att tcc ttt cag ggt 576 Met Ile Val Asp Leu Leu Ser Glu Lys Lys Thr Ile Ser Phe Gln Gly 180 185 190 tgt atg gct caa ctt ttt atg gat cat tta ttt gct ggt gct gaa gtc 624 Cys Met Ala Gln Leu Phe Met Asp His Leu Phe Ala Gly Ala Glu Val 195 200 205 att ctt ctg gtg gta atg gcc tat gat cga tac atg gcc atc tgt aag 672 Ile Leu Leu Val Val Met Ala Tyr Asp Arg Tyr Met Ala Ile Cys Lys 210 215 220 cct ctt cat gaa ttg atc acc atg aat cgt cga gtc tgt gtt ctt atg 720 Pro Leu His Glu Leu Ile Thr Met Asn Arg Arg Val Cys Val Leu Met 225 230 235 240 ctg ttg gcg gcc tgg att gga ggc ttt ctt cac tca ttg gtt caa ttt 768 Leu Leu Ala Ala Trp Ile Gly Gly Phe Leu His Ser Leu Val Gln Phe 245 250 255 ctc ttt att tat cag ctc cct ttc tgt gga ccc aat gtc att gac aac 816 Leu Phe Ile Tyr Gln Leu Pro Phe Cys Gly Pro Asn Val Ile Asp Asn 260 265 270 ttc ctg tgt gat ttg tat ccc tta ttg aaa ctt gct tgc acc aat acc 864 Phe Leu Cys Asp Leu Tyr Pro Leu Leu Lys Leu Ala Cys Thr Asn Thr 275 280 285 tat gtc act ggg ctt tct atg ata gct aat gga gga gcg att tgt gct 912 Tyr Val Thr Gly Leu Ser Met Ile Ala Asn Gly Gly Ala Ile Cys Ala 290 295 300 gtc acc ttc ttc act atc ctg ctt tcc tat ggg gtc ata tta cac tct 960 Val Thr Phe Phe Thr Ile Leu Leu Ser Tyr Gly Val Ile Leu His Ser 305 310 315 320 ctt aag act cag agt ttg gaa ggg aaa cga aaa gct ttc tac acc tgt 1008 Leu Lys Thr Gln Ser Leu Glu Gly Lys Arg Lys Ala Phe Tyr Thr Cys 325 330 335 gca tcc cac gtc act gtg gtc att tta ttc ttt gtc ccc tgt atc ttc 1056 Ala Ser His Val Thr Val Val Ile Leu Phe Phe Val Pro Cys Ile Phe 340 345 350 ttg tat gca agg ccc aat tct act ttt ccc att gat aaa tcc atg act 1104 Leu Tyr Ala Arg Pro Asn Ser Thr Phe Pro Ile Asp Lys Ser Met Thr 355 360 365 gta gtt cta act ttt ata act ccc atg ctg aac cca cta atc tat acc 1152 Val Val Leu Thr Phe Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr 370 375 380 ctg aag aat gca gaa atg aaa agt gcc atg agg aaa ctt tgg agt aaa 1200 Leu Lys Asn Ala Glu Met Lys Ser Ala Met Arg Lys Leu Trp Ser Lys 385 390 395 400 aaa gta agc tta gct ggg aaa tgg ctg tat cac tca tga 1239 Lys Val Ser Leu Ala Gly Lys Trp Leu Tyr His Ser 405 410 <210> 378 <211> 412 <212> PRT <213> Homo sapiens <400> 378 Met Asn Glu Asn Met Gln Cys Phe Val Phe Cys Ser Cys Asp Ser Leu 1 5 10 15 Leu Arg Met Met Val Ser Arg Phe Ile His Val Pro Phe Val Lys Met 20 25 30 Lys Arg Ile Ile Val Gly Gly Tyr Ser Lys His Phe Phe Ser Asn Glu 35 40 45 Leu Leu Cys Val Arg Pro Trp Ser Gly Lys Thr Trp Ser Ile Arg His 50 55 60 His Ile Phe Asp Met Glu Leu Leu Thr Asn Asn Leu Lys Phe Ile Thr 65 70 75 80 Asp Pro Phe Val Cys Arg Leu Arg His Leu Ser Pro Thr Pro Ser Glu 85 90 95 Glu His Met Lys Asn Lys Asn Asn Val Thr Glu Phe Ile Leu Leu Gly 100 105 110 Leu Thr Gln Asn Pro Glu Gly Gln Lys Val Leu Phe Val Thr Phe Leu 115 120 125 Leu Ile Tyr Met Val Thr Ile Met Gly Asn Leu Leu Ile Ile Val Thr 130 135 140 Ile Met Ala Ser Gln Ser Leu Gly Ser Pro Met Tyr Phe Phe Leu Ala 145 150 155 160 Ser Leu Ser Phe Ile Asp Thr Val Tyr Ser Thr Ala Phe Ala Pro Lys 165 170 175 Met Ile Val Asp Leu Leu Ser Glu Lys Lys Thr Ile Ser Phe Gln Gly 180 185 190 Cys Met Ala Gln Leu Phe Met Asp His Leu Phe Ala Gly Ala Glu Val 195 200 205 Ile Leu Leu Val Val Met Ala Tyr Asp Arg Tyr Met Ala Ile Cys Lys 210 215 220 Pro Leu His Glu Leu Ile Thr Met Asn Arg Arg Val Cys Val Leu Met 225 230 235 240 Leu Leu Ala Ala Trp Ile Gly Gly Phe Leu His Ser Leu Val Gln Phe 245 250 255 Leu Phe Ile Tyr Gln Leu Pro Phe Cys Gly Pro Asn Val Ile Asp Asn 260 265 270 Phe Leu Cys Asp Leu Tyr Pro Leu Leu Lys Leu Ala Cys Thr Asn Thr 275 280 285 Tyr Val Thr Gly Leu Ser Met Ile Ala Asn Gly Gly Ala Ile Cys Ala 290 295 300 Val Thr Phe Phe Thr Ile Leu Leu Ser Tyr Gly Val Ile Leu His Ser 305 310 315 320 Leu Lys Thr Gln Ser Leu Glu Gly Lys Arg Lys Ala Phe Tyr Thr Cys 325 330 335 Ala Ser His Val Thr Val Val Ile Leu Phe Phe Val Pro Cys Ile Phe 340 345 350 Leu Tyr Ala Arg Pro Asn Ser Thr Phe Pro Ile Asp Lys Ser Met Thr 355 360 365 Val Val Leu Thr Phe Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr 370 375 380 Leu Lys Asn Ala Glu Met Lys Ser Ala Met Arg Lys Leu Trp Ser Lys 385 390 395 400 Lys Val Ser Leu Ala Gly Lys Trp Leu Tyr His Ser 405 410 <210> 379 <211> 948 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(948) <400> 379 atg tcc ata acc aaa gcc tgg aac agc tca tca gtg acc atg ttc atc 48 Met Ser Ile Thr Lys Ala Trp Asn Ser Ser Ser Val Thr Met Phe Ile 1 5 10 15 ctc ctg gga ttc aca gac cat cca gaa ctc cag gcc ctc ctc ttt gtg 96 Leu Leu Gly Phe Thr Asp His Pro Glu Leu Gln Ala Leu Leu Phe Val 20 25 30 acc ttc ctg ggc atc tat ctt acc acc ctg gcc tgg aac ctg gcc ctc 144 Thr Phe Leu Gly Ile Tyr Leu Thr Thr Leu Ala Trp Asn Leu Ala Leu 35 40 45 att ttt ctg atc aga ggt gac acc cat ctg cac aca ccc atg tac ttc 192 Ile Phe Leu Ile Arg Gly Asp Thr His Leu His Thr Pro Met Tyr Phe 50 55 60 ttc cta agc aac tta tct ttc att gac atc tgc tac tct tct gct gtg 240 Phe Leu Ser Asn Leu Ser Phe Ile Asp Ile Cys Tyr Ser Ser Ala Val 65 70 75 80 gct ccc aat atg ctc act gac ttc ttc tgg gag cag aag acc ata tca 288 Ala Pro Asn Met Leu Thr Asp Phe Phe Trp Glu Gln Lys Thr Ile Ser 85 90 95 ttt gtg ggc tgt gct gct cag ttt ttt ttc ttt gtc ggc atg ggt ctg 336 Phe Val Gly Cys Ala Ala Gln Phe Phe Phe Phe Val Gly Met Gly Leu 100 105 110 tct gag tgc ctc ctc ctg act gct atg gca tac gac cga tat gca gcc 384 Ser Glu Cys Leu Leu Leu Thr Ala Met Ala Tyr Asp Arg Tyr Ala Ala 115 120 125 atc tcc agc ccc ctt ctc tac ccc act atc atg acc cag ggc ctc tgt 432 Ile Ser Ser Pro Leu Leu Tyr Pro Thr Ile Met Thr Gln Gly Leu Cys 130 135 140 aca cgc atg gtg gtt ggg gca tat gtt ggt ggc ttc ctg agc tcc ctg 480 Thr Arg Met Val Val Gly Ala Tyr Val Gly Gly Phe Leu Ser Ser Leu 145 150 155 160 atc cag gcc agc tcc ata ttt agg ctt cac ttt tgc gga ccc aac atc 528 Ile Gln Ala Ser Ser Ile Phe Arg Leu His Phe Cys Gly Pro Asn Ile 165 170 175 atc aac cac ttc ttc tgc gac ctc cca cca gtc ctg gct ctg tct tgc 576 Ile Asn His Phe Phe Cys Asp Leu Pro Pro Val Leu Ala Leu Ser Cys 180 185 190 tc t gac acc ttc ctc agt caa gtg gtg aat ttc ctc gtg gtg gtc act 624 Ser Asp Thr Phe Leu Ser Gln Val Val Asn Phe Leu Val Val Val Thr 195 200 205 gtc gga gga aca tcg ttc ctc caa ctc ctt atc tcc tat ggt tac ata 672 Val Gly Gly Thr Ser Phe Leu Gln Leu Leu Ile Ser Tyr Gly Tyr Ile 210 215 220 gtg tct gcg gtc ctg aag atc cct tca gca gag ggc cga tgg aaa gcc 720 Val Ser Ala Val Leu Lys Ile Pro Ser Ala Glu Gly Arg Trp Lys Ala 225 230 235 240 tgc aac acg tgt gcc tcg cat ctg atg gtg gtg act ctg ctg ttt ggg 768 Cys Asn Thr Cys Ala Ser His Leu Met Val Val Thr Leu Leu Phe Gly 245 250 255 aca gcc ctt ttc gtg tac ttg cga ccc agc tcc agc tac ttg cta ggc 816 Thr Ala Leu Phe Val Tyr Leu Arg Pro Ser Ser Ser Tyr Leu Leu Gly 260 265 270 agg gac aag gtg gtg tct gtt ttc tat tca ttg gtg atc ccc atg ctg 864 Arg Asp Lys Val Val Ser Val Phe Tyr Ser Leu Val Ile Pro Met Leu 275 280 285 aac cct ctc att tac agt ttg agg aac aaa gag atc aag gat gcc ctg 912 Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Glu Ile Lys Asp Ala Leu 290 295 300 tgg aag gtg ttg gaa agg aag aaa gtg ttt tct tag 948 Trp Lys Val Leu Glu Arg Lys Lys Val Phe Ser 305 310 315 <210> 380 <211> 315 <212> PRT <213> Homo sapiens <400> 380 Met Ser Ile Thr Lys Ala Trp Asn Ser Ser Ser Val Thr Met Phe Ile 1 5 10 15 Leu Leu Gly Phe Thr Asp His Pro Glu Leu Gln Ala Leu Leu Phe Val 20 25 30 Thr Phe Leu Gly Ile Tyr Leu Thr Thr Leu Ala Trp Asn Leu Ala Leu 35 40 45 I le Phe Leu Ile Arg Gly Asp Thr His Leu His Thr Pro Met Tyr Phe 50 55 60 Phe Leu Ser Asn Leu Ser Phe Ile Asp Ile Cys Tyr Ser Ser Ala Val 65 70 75 80 Ala Pro Asn Met Leu Thr Asp Phe Phe Trp Glu Gln Lys Thr Ile Ser 85 90 95 Phe Val Gly Cys Ala Ala Gln Phe Phe Phe Phe Val Gly Met Gly Leu 100 105 110 Ser Glu Cys Leu Leu Leu Thr Ala Met Ala Tyr Asp Arg Tyr Ala Ala 115 120 125 Ile Ser Ser Pro Leu Leu Tyr Pro Thr Ile Met Thr Gln Gly Leu Cys 130 135 140 Thr Arg Met Val Val Gly Ala Tyr Val Gly Gly Phe Leu Ser Ser Leu 145 150 155 160 Ile Gln Ala Ser Ser Ile Phe Arg Leu His Phe Cys Gly Pro Asn Ile 165 170 175 Ile Asn His Phe Phe Cys Asp Leu Pro Pro Val Leu Ala Leu Ser Cys 180 185 190 Ser Asp Thr Phe Leu Ser Gln Val Val Asn Phe Leu Val Val Val Thr 195 200 205 Val Gly Gly Thr Ser Phe Leu Gln Leu Leu Ile Ser Tyr Gly Tyr Ile 210 215 220 Val Ser Ala Val Leu Lys Ile Pro Ser Ala Glu Gly Arg Trp Lys Ala 225 230 235 240 Cys Asn Thr Cys Ala Ser His Leu Met Val Val Thr Leu Leu Phe Gly 245 250 255 Thr Ala Leu Phe Val Tyr Leu Arg Pro Ser Ser Ser Tyr Leu Leu Gly 260 265 270 Arg Asp Lys Val Val Ser Val Phe Tyr Ser Leu Val Ile Pro Met Leu 275 280 285 Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Glu Ile Lys Asp Ala Leu 290 295 300 Trp Lys Val Leu Glu Arg Lys Lys Val Phe Ser 305 310 315 <210> 381 <211> 945 <212> DNA <213> Homo sapiens <220> < 221> CDS <222> (1)..(945) <400> 381 atg gat cag aga aat tac acc aga gtg aaa gaa ttt acc ttc ctg gga 48 Met Asp Gln Arg Asn Tyr Thr Arg Val Lys Glu Phe Thr Phe Leu Gly 1 5 10 15 att act cag tcc cga gaa ctg agc cag gtc tta ttt acc ttc ctg ttt 96 Ile Thr Gln Ser Arg Glu Leu Ser Gln Val Leu Phe Thr Phe Leu Phe 20 25 30 ttg gtg tac atg aca act cta atg gga aac ttc ctc atc atg gtt aca 144 Leu Val Tyr Met Thr Thr Leu Met Gly Asn Phe Leu Ile Met Val Thr 35 40 45 gtt acc tgt gaa tct cac ctt cat acg ccc atg tac ttc ctg ctc cgc 192 Val Thr Cys Glu Ser His Leu His Thr Pro Met Tyr Phe Leu Leu Arg 50 55 60 aac ctg tct att ctt gac atc tgc ttt tcc tcc atc aca gct cct aag 240 Asn Leu Ser Ile Leu Asp Ile Cys Phe Ser Ser Ile Thr Ala Pro Lys 65 70 75 80 gtc ctg ata gat ctt cta tca gag aca aaa acc atc tcc ttc agt ggc 288 Val Leu Ile Asp Leu Leu Ser Glu Thr Lys Thr Ile Ser Phe Ser Gly 85 90 95 tgt gtc act caa atg ttc ttc ttc cac ctt ctg ggg gga gca gac gtt 336 Cys Val Thr Gln Met Phe Phe Phe His Leu Leu Gly Gly Ala Asp Val 100 105 110 ttt tct ctc tct gtg atg gcg ttt gac cgc tat ata gcc atc tcc aag 384 Phe Ser Leu Ser Val Met Ala Phe Asp Arg Tyr Ile Ala Ile Ser Lys 115 120 125 ccc ctg cac tat atg acc atc atg agt agg ggg cga tgc aca ggc ctc 432 Pro Leu His Tyr Met Thr Ile Met Ser Arg Gly Arg Cys Thr Gly Leu 130 135 140 atc gtg ggc ttc ctg ggt ggg ggg ctt gtc cac tcc ata gcg cag att 480 Ile Val Gly Phe Leu Gly Gly Gly Leu Val His Ser Ile Ala Gln Ile 145 150 155 160 tct cta ttg ctc cca ctc cct gtc tgt gga ccc aat gtt ctt gac act 528 Ser Leu Leu Leu Pro Leu Pro Val Cys Gly Pro Asn Val Leu Asp Thr 165 170 175 ttc tac tgc gat gtc ccc cag gtc ctc aaa ctt gcc tgc act gac acc 576 Phe Tyr Cys Asp Val Pro Gln Val Leu Lys Leu Ala Cys Thr Asp Thr 180 185 190 ttc act ctg gag ctc ctg atg att tca aat aat ggg tta gtc agt tgg 624 Phe Thr Leu Glu Leu Leu Met Ile Ser Asn Asn Gly Leu Val Ser Trp 195 200 205 ttt gta ttc ttc ttt ctc ctc ata tct tac acg gtc atc ttg atg atg 672 Phe Val Phe Phe Phe Leu Leu Ile Ser Tyr Thr Val Ile Leu Met Met 210 215 220 ctg agg tct cac act ggg gaa ggc agg agg aaa gcc atc tcc acc tgc 720 Leu Arg Ser His Thr Gly Glu Gly Arg Arg Lys Ala Ile Ser Thr Cys 225 230 235 240 acc tcc cac atc acc gtg gtg acc ctg cat ttc gtg ccc tgc atc tat 768 Thr Ser His Ile Thr Val Val Thr Leu His Phe Val Pro Cys Ile Tyr 245 250 255 gtc tat gcc cgg ccc ttc act gcc ctc ccc aca gac act gcc atc tct 816 Val Tyr Ala Arg Pro Phe Thr Ala Leu Pro Thr Asp Thr Ala Ile Ser 260 265 270 gtc acc ttc act gtc atc tcc cct ttg ctc aat cct ata att tac acg 864 Val Thr Phe Thr Val Ile Ser Pro Leu Leu Asn Pro Ile Ile Tyr Thr 275 280 285 ctg agg aat cag gaa atg aag ttg gcc atg agg aaa ctg aag aga cgg 912 Leu Arg Asn Gln Glu Met Lys Leu Ala Met Arg Lys Leu Lys Arg Arg 290 295 300 cta gga caa tca gaa agg att tta att caa taa 945 Leu Gly Gln Ser Glu Arg Ile Leu Ile Gln 305 310 315 <210> 382 <211> 314 <212> PRT <213> Homo sapiens <400> 382 Met Asp Gln Arg Asn Tyr Thr Arg Val Lys Glu Phe Thr Phe Leu Gly 1 5 10 15 Ile Thr Gln Ser Arg Glu Leu Ser Gln Val Leu Phe Thr Phe Leu Phe 20 25 30 Leu Val Tyr Met Thr Thr Leu Met Gly Asn Phe Leu Ile Met Val Thr 35 40 45 Val Thr Cys Glu Ser His Leu His Thr Pro Met Tyr Phe Leu Leu Arg 50 55 60 Asn Leu Ser Ile Leu Asp Ile Cys Phe Ser Ser Ile Thr Ala Pro Lys 65 70 75 80 Val Leu Ile Asp Leu Leu Ser Glu Thr Lys Thr Ile Ser Phe Ser Gly 85 90 95 Cys Val Thr Gln Met Phe Phe Phe His Leu Leu Gly Gly Ala Asp Val 100 105 110 Phe Ser Leu Ser Val Met Ala Phe Asp Arg Tyr Ile Ala Ile Ser Lys 115 120 125 Pro Leu His Tyr Met Thr Ile Met Ser Arg Gly Arg Cys Thr Gly Leu 130 135 140 Ile Val Gly Phe Leu Gly Gly Gly Leu Val His Ser Ile Ala Gln Ile 145 150 155 160 Ser Leu Leu Leu Pro Leu Pro Val Cys Gly Pro Asn Val Leu Asp Thr 165 170 175 Phe Tyr Cys Asp Val Pro Gln Val Leu Lys Leu Ala Cys Thr Asp Thr 180 185 190 Phe Thr Leu Glu Leu Leu Met Ile Ser Asn Asn Gly Leu Val Ser Trp 195 200 205 Phe Val Phe Phe Phe Leu Leu Ile Ser Tyr Thr Val Ile Leu Met Met 210 215 220 Leu Arg Ser His Thr Gly Glu Gly Arg Arg Lys Ala Ile Ser Thr Cys 225 230 235 240 Thr Ser His Ile Thr Val Val Thr Leu His Phe Val Pro Cys Ile Tyr 245 250 255 Val Tyr Ala Arg Pro Phe Thr Ala Leu Pro Thr Asp Thr Ala Ile Ser 260 265 270 Val Thr Phe Thr Val Ile Ser Pro Leu Leu Asn Pro Ile Ile Tyr Thr 275 280 285 Leu Arg Asn Gln Glu Met Lys Leu Ala Met Arg Lys Leu Lys Arg Arg 290 295 300 Leu Gly Gln Ser Glu Arg Ile Leu Ile Gln 305 310 <210> 383 <211> 936 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(936) <400> 383 atg gag atg gaa aac tgc acc agg gta aaa gaa ttt att ttc ctt ggc 48 Met Glu Met Glu Asn Cys Thr Arg Val Lys Glu Phe Ile Phe Leu Gly 1 5 10 15 ctg acc cag aat cgg gaa gtg agc tta gtc tta ttt ctt ttc cta ctc 96 Leu Thr Gln Asn Arg Glu Val Ser Leu Val Leu Phe Leu Phe Leu Leu 20 25 30 ttg gtg tat gtg aca act ttg ctg gga aac ctc ctc atc atg gtc act 144 Leu Val Tyr Val Thr Thr Leu Leu Gly Asn Leu Leu Ile Met Val Thr 35 40 45 gtt acc tgt gaa tct cgc ctt cac acg ccc atg tat ttt ttg ctc cat 192 Val Thr Cys Glu Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu His 50 55 60 aat tta tct att gcc gat atc tgc ttc tct tcc atc aca gtg ccc aag 240 Asn Leu Ser Ile Ala Asp Ile Cys Phe Ser Ser Ile Thr Val Pro Lys 65 70 75 80 gtt ctg gtg gac ctt ctg tct gaa aga aag acc atc tcc ttc aat cat 288 Val Leu Val Asp Leu Leu Ser Glu Arg Lys Thr Ile Ser Phe Asn His 85 90 95 tgc ttc act cag atg ttt cta ttc cac ctt att gga ggg gtg gat gta 336 Cys Phe Thr Gln Met Phe Leu Phe His Leu Ile Gly Gly Val Asp Val 100 105 110 ttt tct ctt tcg gtg atg gca ttg gat cga tat gtg gcc atc tcc aag 384 Phe Ser Leu Ser Val Met Ala Leu Asp Arg Tyr Val Ala Ile Ser Lys 115 120 125 ccc ctg cac tat gcg act atc atg agt aga gac cat tgc att ggg ctc 432 Pro Leu His Tyr Ala Thr Ile Met Ser Arg Asp His Cys Ile Gly Leu 130 135 140 aca gtg gct gcc tgg ttg ggg ggc ttt gtc cac tcc atc gtg cag att 480 Thr Val Ala Ala Trp Leu Gly Gly Phe Val His Ser Ile Val Gln Ile 145 150 155 160 tcc ctg ttg ctc cca ctc cct ttc tgc gga ccc aat gtt ctt gac act 528 Ser Leu Leu Leu Pro Leu Pro Phe Cys Gly Pro Asn Val Leu Asp Thr 165 170 175 ttc tac tgt gat gtc cac cgg gtc ctc aaa ctg gcc cat aca gac att 576 Phe Tyr Cys Asp Val His Arg Val Leu Lys Leu Ala His Thr Asp Ile 180 185 190 ttc ata ctt gaa cta cta atg att tcc aac aat gga ctg ctc acc aca 624 Phe Ile Leu Glu Leu Leu Met Ile Ser Asn Asn Gly Leu Leu Thr Thr 195 200 205 ct g tgg ttt ttc ctg ctc ctg gtg tcc tac ata gtc ata tta tca tta 672 Leu Trp Phe Phe Leu Leu Leu Val Ser Tyr Ile Val Ile Leu Ser Leu 210 215 220 ccc aag tct cag gca gga gag ggc agg agg aaa gcc atc tcc acc tgc 720 Pro Lys Ser Gln Ala Gly Glu Gly Arg Arg Lys Ala Ile Ser Thr Cys 225 230 235 240 acc tcc cac atc act gtg gtg acc ctg cat ttc gtg ccc tgc atc tat 768 Thr Ser His Ile Thr Val Val Thr Leu His Phe Val Pro Cys Ile Tyr 245 250 255 gtc tat gcc cgg ccc ttc act gcc ctc ccc atg gat aag gcc atc tct 816 Val Tyr Ala Arg Pro Phe Thr Ala Leu Pro Met Asp Lys Ala Ile Ser 260 265 270 gtc acc ttc act gtc atc tcc cct ctg ctc aac ccc ttg atc tac act 864 Val Thr Phe Thr Val Ile Ser Pro Leu Leu Asn Pro Leu Ile Tyr Thr 275 280 285 ctg agg aac cat gag atg aag tca gcc atg agg aga ctg aag aga aga 912 Leu Arg Asn His Glu Met Lys Ser Ala Met Arg Arg Leu Lys Arg Arg 290 295 300 ctt gtg cct tct gat aga aaa tag 936 Leu Val Pro Ser Asp Arg Lys 305 310 <210> 384 <211> 311 <212> PRT <213> Homo sapiens <400> 384 Met Glu Met Glu Asn Cys Thr Arg Val Lys Glu Phe Ile Phe Leu Gly 1 5 10 15 Leu Thr Gln Asn Arg Glu Val Ser Leu Val Leu Phe Leu Phe Leu Leu 20 25 30 Leu Val Tyr Val Thr Thr Leu Leu Gly Asn Leu Leu Ile Met Val Thr 35 40 45 Val Thr Cys Glu Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu His 50 55 60 Asn Leu Ser Ile Ala Asp Ile Cys Phe Ser Ser Ile Thr Val Pro Lys 65 70 75 80 Val Leu Val Asp Leu Leu Ser Glu Arg Lys Thr Ile Ser Phe Asn His 85 90 95 Cys Phe Thr Gln Met Phe Leu Phe His Leu Ile Gly Gly Val Asp Val 100 105 110 Phe Ser Leu Ser Val Met Ala Leu Asp Arg Tyr Val Ala Ile Ser Lys 115 120 125 Pro Leu His Tyr Ala Thr Ile Met Ser Arg Asp His Cys Ile Gly Leu 130 135 140 Thr Val Ala Ala Trp Leu Gly Gly Phe Val His Ser Ile Val Gln Ile 145 150 155 160 Ser Leu Leu Leu Pro Leu Pro Phe Cys Gly Pro Asn Val Leu Asp Thr 165 170 175 Phe Tyr Cys Asp Val His Arg Val Leu Lys Leu Ala His Thr Asp Ile 180 185 190 Phe Ile Leu Glu Leu Leu Met Ile Ser Asn Asn Gly Leu Leu Thr Thr 195 200 205 Leu Trp Phe Phe Leu Leu Leu Val Ser Tyr Ile Val Ile Leu Ser Leu 210 215 220 Pro Lys Ser Gln Ala Gly Glu Gly Arg Arg Lys Ala Ile Ser Thr Cys 225 230 235 240 Thr Ser His Ile Thr Val Val Thr Leu His Phe Val Pro Cys Ile Tyr 245 250 255 Val Tyr Ala Arg Pro Phe Thr Ala Leu Pro Met Asp Lys Ala Ile Ser 260 265 270 Val Thr Phe Thr Val Ile Ser Pro Leu Leu Asn Pro Leu Ile Tyr Thr 275 280 285 Leu Arg Asn His Glu Met Lys Ser Ala Met Arg Arg Leu Lys Arg Arg 290 295 300 Leu Val Pro Ser Asp Arg Lys 305 310 <210> 385 <211> 1008 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1008) <400> 385 atg gca cag gtg agg gcg ctg cat aaa atc atg gcc ctt ttt tct gct 48 Met Ala Gln Val Arg Ala Leu His Lys Ile Met Ala Leu Phe Ser Ala 1 5 10 15 aac agc ata ggt gct atg aac aac tct gac act cgc ata gca ggc tgc 96 Asn Ser Ile Gly Ala Met Asn Asn Ser Asp Thr Arg Ile Ala Gly Cys 20 25 30 ttc ctc act ggc atc cct ggg ctg gag caa cta cat atc tgg ctg tcc 144 Phe Leu Thr Gly Ile Pro Gly Leu Glu Gln Leu His Ile Trp Leu Ser 35 40 45 atc ccc ttc tgc atc atg tac atc gct gcc ctg gaa ggc aat ggc atc 192 Ile Pro Phe Cys Ile Met Tyr Ile Ala Ala Leu Glu Gly Asn Gly Ile 50 55 60 cta att tgt gtc atc ctc tcc cag gca atc ctg cat gag ccc atg tac 240 Leu Ile Cys Val Ile Leu Ser Gln Ala Ile Leu His Glu Pro Met Tyr 65 70 75 80 ata ttc tta tct atg ctg gcc agt gct gat gtc ttg ctc tct acc acc 288 Ile Phe Leu Ser Met Leu Ala Ser Ala Asp Val Leu Leu Ser Thr Thr 85 90 95 acc atg cct aag gcc ctg gcc aat ttg tgg cta ggt tat agc cac att 336 Thr Met Pro Lys Ala Leu Ala Asn Leu Trp Leu Gly Tyr Ser His Ile 100 105 110 tcc ttt gat ggc tgc ctc act caa aag ttc ttc att cac ttc ctc ttc 384 Ser Phe Asp Gly Cys Leu Thr Gln Lys Phe Phe Ile His Phe Leu Phe 115 120 125 att cac tct gct gtc ctg ctg gcc atg gcc ttt gac cgc tat gtg gcc 432 Ile His Ser Ala Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala 130 135 140 atc tgc tcc ccc ctg cga tat gtc aca atc ctc aca agc aag gtc att 480 Ile Cys Ser Pro Leu Arg Tyr Val Thr Ile Leu Thr Ser Lys Val Ile 145 150 155 160 ggg aag atc gtc act gcc acc ctg agc cgc agc ttc atc att atg ttt 528 Gly Lys Ile Val Thr Ala Thr Leu Ser Arg Ser Phe Ile Ile Met Phe 165 170 175 cca tcc atc ttt ctc ctt gag cac ctg cac tat tgc cag atc aac atc 576 Pro Ser Ile Phe Leu Leu Glu His Leu His Tyr Cys Gln Ile Asn Ile 180 185 190 att gca cac aca ttt tgt gag cac atg ggc att gcc cat ctg tcc tgt 624 Il e Ala His Thr Phe Cys Glu His Met Gly Ile Ala His Leu Ser Cys 195 200 205 tct gat atc tcc atc aat gtc tgg tat ggg ttg gca gct gct ctt ctc 672 Ser Asp Ile Ser Ile Asn Val Trp Tyr Gly Leu Ala Ala Ala Leu Leu 210 215 220 tcc aca ggc ctg gac atc atg ctt att act gtt tcc tac atc cac atc 720 Ser Thr Gly Leu Asp Ile Met Leu Ile Thr Val Ser Tyr Ile His Ile 225 230 235 240 ctc caa gca gtc ttc cgc ctc ctt tct caa gat gcc cgc tcc aag gcc 768 Leu Gln Ala Val Phe Arg Leu Leu Ser Gln Asp Ala Arg Ser Lys Ala 245 250 255 ctg agt acc tgt gga tcc cat atc tgt gtc atc cta ctc ttc tat gtc 816 Leu Ser Thr Cys Gly Ser His Ile Cys Val Ile Leu Leu Phe Tyr Val 260 265 270 cct gcc ctt ttt tct gtc ttt gcc tac agg ttt ggt ggg aga agc atc 864 Pro Ala Leu Phe Ser Val Phe Ala Tyr Arg Phe Gly Gly Arg Ser Ile 275 280 285 cca tgc tat gtc cat att ctc ctg gcc agc ctc tac gtt gtc att cct 912 Pro Cys Tyr Val His Ile Leu Leu Ala Ser Leu Tyr Val Val Ile Pro 290 295 300 cct atg ctc aat ccc gtt att tat gga gtg agg act aag cca ata ctg 960 Pro Met Leu Asn Pro Val Ile Tyr Gly Val Arg Thr Lys Pro Ile Leu 305 310 315 320 gaa ggg gct aag cag atg ttt tca aat ctt gcc aaa gga tct aaa taa 1008 Glu Gly Ala Lys Gln Met Phe Ser Asn Leu Ala Lys Gly Ser Lys 325 330 335 <210> 386 <211> 335 <212> PRT <213> Homo sapiens <400> 386 Met Ala Gln Val Arg Ala Leu His Lys Ile Met Ala Leu Phe Ser Ala 1 5 10 15 Asn Ser Ile Gly Ala Met Asn Asn Ser Asp Thr Arg Ile Ala Gly Cys 20 25 30 Phe Leu Thr Gly Ile Pro Gly Leu Glu Gln Leu His Ile Trp Leu Ser 35 40 45 Ile Pro Phe Cys Ile Met Tyr Ile Ala Ala Leu Glu Gly Asn Gly Ile 50 55 60 Leu Ile Cys Val Ile Leu Ser Gln Ala Ile Leu His Glu Pro Met Tyr 65 70 75 80 Ile Phe Leu Ser Met Leu Ala Ser Ala Asp Val Leu Leu Ser Thr Thr 85 90 95 Thr Met Pro Lys Ala Leu Ala Asn Leu Trp Leu Gly Tyr Ser His Ile 100 105 110 Ser Phe Asp Gly Cys Leu Thr Gln Lys Phe Phe Ile His Phe Leu Phe 115 120 125 Ile His Ser Ala Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala 130 135 140 Ile Cys Ser Pro Leu Arg Tyr Val Thr Ile Leu Thr Ser Lys Val Ile 145 150 155 160 Gly Lys Ile Val Thr Ala Thr Leu Ser Arg Ser Phe Ile Ile Met Phe 165 170 175 Pro Ser Ile Phe Leu Leu Glu His Leu His Tyr Cys Gln Ile Asn Ile 180 185 190 Ile Ala His Thr Phe Cys Glu His Met Gly Ile Ala His Leu Ser Cys 195 200 205 Ser Asp Ile Ser Ile Asn Val Trp Tyr Gly Leu Ala Ala Ala Leu Leu 210 215 220 Ser Thr Gly Leu Asp Ile Met Leu Ile Thr Val Ser Tyr Ile His Ile 225 230 235 240 Leu Gln Ala Val Phe Arg Leu Leu Ser Gln Asp Ala Arg Ser Lys Ala 245 250 255 Leu Ser Thr Cys Gly Ser His Ile Cys Val Ile Leu Leu Phe Tyr Val 260 265 270 Pro Ala Leu Phe Ser Val Phe Ala Tyr Arg Phe Gly Gly Arg Ser Ile 275 280 285 Pro Cys Tyr Val His Ile Leu Leu Ala Ser Leu Tyr Val Val Ile Pro 290 295 300 Pro Met Leu Asn Pro Val Ile Tyr Gly Val Arg Thr Lys Pro Ile Leu 305 310 315 320 Glu Gly Ala Lys Gln Met Phe Ser Asn Leu Ala Lys Gly Ser Lys 325 330 335 <210> 387 <211> 912 < 212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(912) <400> 387 atg agc ttc tct tcc ctg cct act gaa ata cag tca tta ctc ttt ctg 48 Met Ser Phe Ser Ser Leu Pro Thr Glu Ile Gln Ser Leu Leu Phe Leu 1 5 10 15 aca ttt cta acc atc tac ctg gtc acc ctg atg gga aac tgc ctc atc 96 Thr Phe Leu Thr Ile Tyr Leu Val Thr Leu Met Gly Asn Cys Leu Ile 20 25 30 att ctg gtt acc cta gct gac ccc atg cta cac agc ccc atg tac ttc 144 Ile Leu Val Thr Leu Ala Asp Pro Met Leu His Ser Pro Met Tyr Phe 35 40 45 ttc ctc aga aac tta tct ttc ctg gag att ggc ttc aac cta gtc att 192 Phe Leu Arg Asn Leu Ser Phe Leu Glu Ile Gly Phe Asn Leu Val Ile 50 55 60 gtg ccc aaa atg ctg ggg acc ctg ctt gcc cag gac aca acc atc tcc 240 Val Pro Lys Met Leu Gly Thr Leu Leu Ala Gln Asp Thr Thr Ile Ser 65 70 75 80 ttc ctt ggc tgt gcc act cag atg tat ttc ttc ttc ttc ttt gga gtg 288 Phe Leu Gly Cys Ala Thr Gln Met Tyr Phe Phe Phe Phe Phe Gly Val 85 90 95 gct gaa tgc ttc ctc ctg gct acc atg gca tat gac cgc tat gtg gcc 336 Ala Glu Cys Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val Ala 100 105 110 atc tgc agt ccc ttg cac tac cca gtc atc atg aac caa agg act cgt 384 Ile Cys Ser Pro Leu His Tyr Pro Val Ile Met Asn Gln Arg Thr Arg 115 120 125 gcc aaa ctg gct gct gcc tcc tgg ttc cca ggc ttt cct gta gct act 432 Ala Lys Leu Ala Ala Ala Ser Trp Phe Pro Gly Phe Pro Val Ala Thr 130 135 140 gtg cag acc aca tgg ctc ttc agt ttt cca ttc tgt ggc acc aac aag 480 Val Gln Thr Thr Trp Leu Phe Ser Phe Pro Phe Cys Gly Thr Asn Lys 145 150 155 160 gtg aac cac ttc ttc tgt gac agc cca cct gtg ctg agg ctg gtc tgt 528 Val Asn His Phe Phe Cys Asp Ser Pro Pro Val Leu Arg Leu Val Cys 165 170 175 gca gac aca gca ctc ttt gag atc tac gcc atc gtc gga acc att ctg 576 Ala Asp Thr Ala Leu Phe Glu Ile Tyr Ala Ile Val Gly Thr Ile Leu 180 185 190 gtg gtc atg atc ccc tgc ttg ctg atc ttg tgt tcc tat act cac att 624 Val Val Met Ile Pro Cys Leu Leu Ile Leu Cys Ser Tyr Thr His Ile 195 200 205 gct gct gcc atc ctc aag atc cca tca gct aaa ggg aag aat aaa gcc 672 Ala Ala Ala Ile Leu Lys Ile Pro Ser Ala Lys Gly Lys Asn Lys Ala 210 215 220 ttt tct aca tgt tcc tca cac ctc ctt gtt gtc tct ctt ttc tat ata 720 Phe Ser Thr Cys Ser Ser His Leu Leu Val Val Ser Leu Phe Tyr Ile 225 230 235 240 tca tta agc ctc acc tac ttc cgg cct aaa tca aat aat tca cct gag 768 Ser Leu Ser Leu Thr Tyr Phe Arg Pro Lys Ser Asn Asn Ser Pro Glu 245 250 255 ggc aag aag ctg cta tca ttg tcc tac act gtt atg act ccc atg ttg 816 Gly Lys Lys Leu Leu Ser Leu Ser Tyr Thr Val Met Thr Pro Met Leu 260 265 270 aac ccc att atc tac agc ctg aga aat aac gag gtg aag aat gcc ctc 864 Asn Pro Ile Ile Tyr Ser Leu Arg Asn Asn Glu Val Lys Asn Ala Leu 275 280 285 agc agg acg gtc tct aag gcc cta gcc ctc aga aac tgt atc cca tag 912 Ser Arg Thr Val Ser Lys Ala Leu Ala Leu Arg Asn Cys Ile Pro 290 295 300 <210> 388 <211> 303 <212> PRT <213> Homo sapiens <400> 388 Met Ser Phe Ser Ser Leu Pro Thr Glu Ile Gln Ser Leu Leu Phe Leu 1 5 10 15 Thr Phe Leu Thr Ile Tyr Leu Val Thr Leu Met Gly Asn Cys Leu Ile 20 25 30 Ile Leu Val Thr Leu Ala Asp Pro Met Leu His Ser Pro Met Tyr Phe 35 40 45 Phe Leu Arg Asn Leu Ser Phe Leu Glu Ile Gly Phe Asn Leu Val Ile 50 55 60 Val Pro Lys Met Leu Gly Thr Leu Leu Ala Gln Asp Thr Thr Ile Ser 65 70 75 80 Phe Leu Gly Cys Ala Thr Gln Met Tyr Phe Phe Phe Phe Phe Gly Val 85 90 95 Ala Glu Cys Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val Ala 100 105 110 Ile Cys Ser Pro Leu His Tyr Pro Val Ile Met Asn Gln Arg Thr Arg 115 120 125 Ala Lys Leu Ala Ala Ala Ser Trp Phe Pro Gly Phe Pro Val Ala Thr 130 135 140 Val Gln Thr Thr Trp Leu Phe Ser Phe Pro Phe Cys Gly Thr Asn Lys 145 150 155 160 Val Asn His Phe Phe Cys Asp Ser Pro Pro Val Leu Arg Leu Val Cys 165 170 175 Ala Asp Thr Ala Leu Phe Glu Ile Tyr Ala Ile Val Gly Thr Ile Leu 180 185 190 Val Val Met Ile Pro Cys Leu Leu Ile Leu Cys Ser Tyr Thr His Ile 195 200 205 Ala Ala Ala Ile Leu Lys Ile Pro Ser Ala Lys Gly Lys Asn Lys Ala 210 215 220 Phe Ser Thr Cys Ser Ser His Leu Leu Val Val Ser Leu Phe Tyr Ile 225 230 235 240 Ser Leu Ser Leu Thr Tyr Phe Arg Pro Lys Ser Asn Asn Ser Pro Glu 245 250 255 Gly Lys Lys Leu Leu Ser Leu Ser Tyr Thr Val Met Thr Pro Met Leu 260 265 270 Asn Pro Ile Ile Tyr Ser Leu Arg Asn Asn Glu Val Lys Asn Ala Leu 275 280 285 Ser Arg Thr Val Ser Lys Ala Leu Ala Leu Arg Asn Cys Ile Pro 290 295 300 <210> 389 <211> 945 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(945) <400> 389 atg aaa aga caa aat caa agc tgt gtg gtt gaa ttc atc ctc ctg ggc 48 Met Lys Arg Gln Asn Gln Ser Cys Val Val Glu Phe Ile Leu Leu Gly 1 5 10 15 ttt tct aac ttt cct gag ctc cag gtg cag ctc ttt ggg gtt ttc cta 96 Phe Ser Asn Phe Pro Glu Leu Gln Val Gln Leu Phe Gly Val Phe Leu 20 25 30 gtt att tat gtg gtg acc ctg atg gga aat gcc atc att aca gtc atc 144 Val Ile Tyr Val Val Thr Leu Met Gly Asn Ala Ile Ile Thr Val Ile 35 40 45 atc tcc tta aac cag agc ctc cac gtt ccc atg tac ctg ttc ctc ctg 192 Ile Ser Leu Asn Gln Ser Leu His Val Pro Met Tyr Leu Phe Leu Leu 50 55 60 aac cta tct gtg gtg gag gtg agt ttc agt gca gtc att acg cct gaa 240 Asn Leu Ser Val Val Glu Val Ser Phe Ser Ala Val Ile Thr Pro Glu 65 70 75 80 atg ctg gtg gtg ctc tct act gag aaa act atg att tct ttt gtg ggc 288 Met Leu Val Val Leu Ser Thr Glu Lys Thr Met Ile Ser Phe Val Gly 85 90 95 tgt ttt gca cag atg tat ttc atc ctt ctt ttt ggt ggg act gaa tgt 336 Cys Phe Ala Gln Met Tyr Phe Ile Leu Leu Phe Gly Gly Thr Glu Cys 100 105 110 ttt ctc ctg gga gcg atg gct tat gac cga ttt gct gca att tgc cat 384 Phe Leu Leu Gly Ala Met Ala Tyr Asp Arg Phe Ala Ala Ile Cys His 115 120 125 cct ctg aac tac cca gtg att atg aac aga ggg gtt ttt atg aaa tta 432 Pro Leu Asn Tyr Pro Val Ile Met Asn Arg Gly Val Phe Met Lys Leu 130 135 140 gta ata ttc tca tgg atc tca ggg atc atg gtg gct act gtg cag acc 480 Val Ile Phe Ser Trp Ile Ser Gly Ile Met Val Ala Thr Val Gln Thr 145 150 155 160 act tgg gta ttt agt ttt cca ttt tgt ggc ccc aat gaa att aat cat 528 Thr Trp Val Phe Ser Phe Pro Phe Cys Gly Pro Asn Glu Ile Asn His 165 170 175 ctc ttc tgt gag act ccc ccg gta cta gag ctt gtg tgt gca gac acc 576 Leu Phe Cys Glu Thr Pro Pro Val Leu Glu Leu Val Cys Ala Asp Thr 180 185 190 ttc tta ttt gaa atc tat gcc ttc aca ggc acc att ttg att gtt atg 624 Phe Leu Phe Glu Ile Tyr Ala Phe Thr Gly Thr Ile Leu Ile Val Met 195 200 205 gtt cct ttc ttg ttg atc ctc ttg tct tac att cga gtt ctg ttt gcc 672 Val Pro Phe Leu Leu Ile Leu Leu Ser Tyr Ile Arg Val Leu Phe Ala 210 215 220 atc ctg aag atg cca tca act act ggg aga caa aag gcc ttt tcc acc 720 Ile Leu Lys Met Pro Ser Thr Thr Gly Arg Gln Lys Ala Phe Ser Thr 225 230 235 240 tgt gcc tct cac ctc aca tct gtg acc ctg ttc tat ggc aca gcc aat 768 Cys Ala Ser His Leu Thr Ser Val Thr Leu Phe Tyr Gly Thr Ala Asn 245 250 255 atg act tat tta caa ccc aaa tct ggc tac tca ccc gaa acc aag aaa 816 Met Thr Tyr Leu Gln Pro Lys Ser Gly Tyr Ser Pro Glu Thr Lys Lys 260 265 270 ctg atc tca ttg gct tac acg ttg ctt acc cct ctg ctc aat ccg ctc 864 Leu Ile Ser Leu Ala Tyr Thr Leu Leu Thr Pro Leu Leu Asn Pro Leu 275 280 285 atc tat agc tta cga aac agt gag atg aag agg act ttg ata aaa cta 912 Ile Tyr Ser Leu Arg Asn Ser Glu Met Lys Arg Thr Leu Ile Lys Leu 290 295 300 tgg cga aga aaa gtg att tta cac aca ttc tga 945 Trp Arg Arg Lys Val Ile Leu His Thr Phe 305 310 315 <210> 390 <211> 314 <212> PRT <213> Homo sapiens <400> 390 Met Lys Arg Gln Asn Gln Ser Cys Val Val Glu Phe Ile Leu Leu Gly 1 5 10 15 Phe Ser Asn Phe Pro Glu Leu Gln Val Gln Leu Phe Gly Val Phe Leu 20 25 30 Val Ile Tyr Val Val Thr Leu Met Gly Asn Ala Ile Ile Thr Val Ile 35 40 45 Ile Ser Leu Asn Gln Ser Leu His Val Pro Met Tyr Leu Phe Leu Leu 50 55 60 Asn Leu Ser Val Val Glu Val Ser Phe Ser Ala Val Ile Thr Pro Glu 65 70 75 80 Met Leu Val Val Leu Ser Thr Glu Lys Thr Met Ile Ser Phe Val Gly 85 90 95 Cys Phe Ala Gln Met Tyr Phe Ile Leu Leu Phe Gly Gly Thr Glu Cys 100 105 110 Phe Leu Leu Gly Ala Met Ala Tyr Asp Arg Phe Ala Ala Ile Cys His 115 120 125 Pro Leu Asn Tyr Pro Val Ile Met Asn Arg Gly Val Phe Met Lys Leu 130 135 140 Val Ile Phe Ser Trp Ile Ser Gly Ile Met Val Ala Thr Val Gln Thr 145 150 155 160 Thr Trp Val Phe Ser Phe Pro Phe Cys Gly Pro Asn Glu Ile Asn His 165 170 175 Leu Phe Cys Glu Thr Pro Pro Val Leu Glu Leu Val Cys Ala Asp Thr 180 185 190 Phe Leu Phe Glu Ile Tyr Ala Phe Thr Gly Thr Ile Leu Ile Val Met 195 200 205 Val Pro Phe Leu Leu Ile Leu Leu Ser Tyr Ile Arg Val Leu Phe Ala 210 215 220 Ile Leu Lys Met Pro Ser Thr Thr Gly Arg Gln Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Thr Ser Val Thr Leu Phe Tyr Gly Thr Ala Asn 245 250 255 Met Thr Tyr Leu Gln Pro Lys Ser Gly Tyr Ser Pro Glu Thr Lys Lys 260 265 270 Leu Ile Ser Leu Ala Tyr Thr Leu Leu Thr Pro Leu Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Ser Glu Met Lys Arg Thr Leu Ile Lys Leu 290 295 300 Trp Arg Arg Lys Val Ile Leu His Thr Phe 305 310 <210> 391 <21 1> 945 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(945) <400> 391 atg gaa aga caa aat caa agc tgt gtg gtt gaa ttc atc ctc ttg ggc 48 Met Glu Arg Gln Asn Gln Ser Cys Val Val Glu Phe Ile Leu Leu Gly 1 5 10 15 ttt tct aac tat cct gag ctc cag ggg cag ctc ttt gtg gct ttc ctg 96 Phe Ser Asn Tyr Pro Glu Leu Gln Gly Gln Leu Phe Val Ala Phe Leu 20 25 30 gtt att tat ctg gtg acc ctg ata gga aat gcc att att ata gtc atc 144 Val Ile Tyr Leu Val Thr Leu Ile Gly Asn Ala Ile Ile Ile Val Ile 35 40 45 gtc tcc cta gac cag agc ctc cac gtt ccc atg tac ctg ttt ctc ctg 192 Val Ser Leu Asp Gln Ser Leu His Val Pro Met Tyr Leu Phe Leu Leu 50 55 60 aac tta tct gtg gtg gac ctg agt ttc agt gca gtt att atg cct gaa 240 Asn Leu Ser Val Val Asp Leu Ser Phe Ser Ala Val Ile Met Pro Glu 65 70 75 80 atg ctg gtg gtc ctc tct act gaa aaa act aca att tct ttt ggg ggc 288 Met Leu Val Val Leu Ser Thr Glu Lys Thr Thr Ile Ser Phe Gly Gly 85 90 95 tgt ttt gca cag atg tat ttc atc ctt ctt ttt ggt ggg gct gaa tgt 336 Cys Phe Ala Gln Met Tyr Phe Ile Leu Leu Phe Gly Gly Ala Glu Cys 100 105 110 ttt ctt ctg gga gca atg gct tat gac cga ttt gct gca att tgc cat 384 Phe Leu Leu Gly Ala Met Ala Tyr Asp Arg Phe Ala Ala Ile Cys His 115 120 125 cct ctc aac tac caa atg att atg aat aaa gga gtt ttt atg aaa tta 432 Pro Leu Asn Tyr Gln Met Ile Met Asn Lys Gly Val Phe Met Lys Leu 130 135 140 att ata ttt tca tgg gcc tta ggt ttt atg tta ggt act gtt caa aca 480 Ile Ile Phe Ser Trp Ala Leu Gly Phe Met Leu Gly Thr Val Gln Thr 145 150 155 160 tca tgg gta tct agt ttt ccc ttt tgt ggc ctt aat gaa att aac cat 528 Ser Trp Val Ser Ser Phe Pro Phe Cys Gly Leu Asn Glu Ile Asn His 165 170 175 ata tct tgt gaa acc cca gca gtg tta gaa ctt gca tgt gca gac acg 576 Ile Ser Cys Glu Thr Pro Ala Val Leu Glu Leu Ala Cys Ala Asp Thr 180 185 190 ttt ttg ttt gaa atc tat gca ttc aca ggc acc ttt ttg att att ttg 624 Phe Leu Phe Glu Ile Tyr Ala Phe Thr Gly Thr Phe Leu Ile Ile Leu 195 200 205 gtt cct ttc ttg ttg ata ctc ttg tct tac att cga gtt ctg ttt gcc 672 Val Pro Phe Leu Leu Ile Leu Leu Ser Tyr Ile Arg Val Leu Phe Ala 210 215 220 atc ctg aag atg cca tca acc act ggg aga caa aag gcc ttt tcc acc 720 Ile Leu Lys Met Pro Ser Thr Thr Gly Arg Gln Lys Ala Phe Ser Thr 225 230 235 240 tgt gcc gct cac ctc aca tct gtg acc cta ttc tat ggc aca gcc agt 768 Cys Ala Ala His Leu Thr Ser Val Thr Leu Phe Tyr Gly Thr Ala Ser 245 250 255 atg act tat tta caa ccc aaa tct ggc tac tca ccg gaa acc aag aaa 816 Met Thr Tyr Leu Gln Pro Lys Ser Gly Tyr Ser Pro Glu Thr Lys Lys 260 265 270 gtg atg tca ttg tct tac tca ctt ctg aca cca ctg ctg aat ctg ctt 864 Val Met Ser Leu Ser Tyr Ser Leu Leu Thr Pro Leu Leu Asn Leu Leu 275 280 285 atc tac agt ttg cga aat agt gag atg aag agg gct ttg atg aaa tta 912 Ile Tyr Ser Leu Arg Asn Ser Glu Met Lys Arg Ala Leu Met Lys Leu 290 295 300 tgg cga agg cga gtg gtt tta cac aca atc tga 945 Trp Arg Arg Arg Val Val Leu His Thr Ile 305 310 315 <210> 392 <21 1> 314 <212> PRT <213> Homo sapiens <400> 392 Met Glu Arg Gln Asn Gln Ser Cys Val Val Glu Phe Ile Leu Leu Gly 1 5 10 15 Phe Ser Asn Tyr Pro Glu Leu Gln Gly Gln Leu Phe Val Ala Phe Leu 20 25 30 Val Ile Tyr Leu Val Thr Leu Ile Gly Asn Ala Ile Ile Ile Val Ile 35 40 45 Val Ser Leu Asp Gln Ser Leu His Val Pro Met Tyr Leu Phe Leu Leu 50 55 60 Asn Leu Ser Val Val Asp Leu Ser Phe Ser Ala Val Ile Met Pro Glu 65 70 75 80 Met Leu Val Val Leu Ser Thr Glu Lys Thr Thr Ile Ser Phe Gly Gly 85 90 95 Cys Phe Ala Gln Met Tyr Phe Ile Leu Leu Phe Gly Gly Ala Glu Cys 100 105 110 Phe Leu Leu Gly Ala Met Ala Tyr Asp Arg Phe Ala Ala Ile Cys His 115 120 125 Pro Leu Asn Tyr Gln Met Ile Met Asn Lys Gly Val Phe Met Lys Leu 130 135 140 Ile Ile Phe Ser Trp Ala Leu Gly Phe Met Leu Gly Thr Val Gln Thr 145 150 155 160 Ser Trp Val Ser Ser Phe Pro Phe Cys Gly Leu Asn Glu Ile Asn His 165 170 175 Ile Ser Cys Glu Thr Pro Ala Val Leu Glu Leu Ala Cys Ala Asp Thr 180 185 190 Phe Leu Phe Glu Ile Tyr Ala Phe Thr Gly Thr Phe Leu Ile Ile Leu 195 200 205 Val Pro Phe Leu Leu Ile Leu Leu Ser Tyr Ile Arg Val Leu Phe Ala 210 215 220 Ile Leu Lys Met Pro Ser Thr Thr Gly Arg Gln Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ala His Leu Thr Ser Val Thr Leu Phe Tyr Gly Thr Ala Ser 245 250 255 Met Thr Tyr Leu Gln Pro Lys Ser Gly Tyr Ser Pro Glu Thr Lys Lys 260 265 270 Val Met Ser Leu Ser Tyr Ser Leu Leu Thr Pro Leu Leu Asn Leu Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Ser Glu Met Lys Arg Ala Leu Met Lys Leu 290 295 300 Trp Arg Arg Arg Val Val Leu His Thr Ile 305 310 <210> 393 <211> 1074 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1074) <400> 393 atg aat aac act att gta ttt gtc ata aaa ata caa ata gaa aaa agt 48 Met Asn Asn Thr Ile Val Phe Val Ile Lys Ile Gln Ile Glu Lys Ser 1 5 10 15 gac ttg aaa tat aga gcc att tca ttg caa gaa atc tca aag att tcc 96 As p Leu Lys Tyr Arg Ala Ile Ser Leu Gln Glu Ile Ser Lys Ile Ser 20 25 30 ctt ctt ttc tgg gtc ctt ctc ttg gtc att tct aga ctt tta cta gcc 144 Leu Leu Phe Trp Val Leu Leu Leu Val Ile Ser Arg Leu Leu Leu Ala 35 40 45 atg aca cta gga aac agc act gaa gtc act gaa ttc tat ctt ctg gga 192 Met Thr Leu Gly Asn Ser Thr Glu Val Thr Glu Phe Tyr Leu Leu Gly 50 55 60 ttt ggt gcc cag cat gag ttt tgg tgt atc ctc ttc att gta ttc ctt 240 Phe Gly Ala Gln His Glu Phe Trp Cys Ile Leu Phe Ile Val Phe Leu 65 70 75 80 ctc atc tat gtg acc tcc ata atg ggt aat agt gga ata atc tta ctc 288 Leu Ile Tyr Val Thr Ser Ile Met Gly Asn Ser Gly Ile Ile Leu Leu 85 90 95 atc aac aca gat tcc aga ttt caa aca ctc acg tac ttt ttt cta caa 336 Ile Asn Thr Asp Ser Arg Phe Gln Thr Leu Thr Tyr Phe Phe Leu Gln 100 105 110 cat ttg gct ttt gtt gat atc tgt tac act tct gct atc act ccc aag 384 His Leu Ala Phe Val Asp Ile Cys Tyr Thr Ser Ala Ile Thr Pro Lys 115 120 125 atg ctc caa agc ttc aca gaa gaa aag aat ttg ata tta ttt cag ggc 432 Met Leu Gln Ser Phe Thr Glu Glu Lys Asn Leu Ile Leu Phe Gln Gly 130 135 140 tgt gtg ata caa ttc tta gtt tat gca aca ttt gca acc agt gac tgt 480 Cys Val Ile Gln Phe Leu Val Tyr Ala Thr Phe Ala Thr Ser Asp Cys 145 150 155 160 tat ctc ctg gct atg atg gca gtg gat cct tat gtt gcc atc tgt aag 528 Tyr Leu Leu Ala Met Met Ala Val Asp Pro Tyr Val Ala Ile Cys Lys 165 170 175 ccc ctt cac tat act gta atc atg tcc cga aca gtc tgc atc cgt ttg 576 Pro Leu His Tyr Thr Val Ile Met Ser Arg Thr Val Cys Ile Arg Leu 180 185 190 gta gct ggt tca tac atc atg ggc tca ata aat gcc tct gta caa aca 624 Val Ala Gly Ser Tyr Ile Met Gly Ser Ile Asn Ala Ser Val Gln Thr 195 200 205 ggt ttt aca tgt tca ctg tcc ttc tgc aag tcc aat agc atc aat cac 672 Gly Phe Thr Cys Ser Leu Ser Phe Cys Lys Ser Asn Ser Ile Asn His 210 215 220 ttt ttc tgt gat gtt ccc cct att ctt gct ctt tca tgc tcc aat gtt 720 Phe Phe Cys Asp Val Pro Pro Ile Leu Ala Leu Ser Cys Ser Asn Val 225 230 235 240 gac atc aac atc atg cta ctt gtt gtc ttt gtg gga tct aac ttg ata 768 Asp Ile Asn Ile Met Leu Leu Val Val Phe Val Gly Ser Asn Leu Ile 245 250 255 ttc act ggg ttg gtc gtc atc ttt tcc tac atc tac atc atg gcc acc 816 Phe Thr Gly Leu Val Val Ile Phe Ser Tyr Ile Tyr Ile Met Ala Thr 260 265 270 atc ctg aaa atg tct tct agt gca gga agg aaa aaa tcc ttc tca aca 864 Ile Leu Lys Met Ser Ser Ser Ala Gly Arg Lys Lys Ser Phe Ser Thr 275 280 285 tgt gct tcc cac ctg acc gca gtc acc att ttc tat ggg aca ctc tct 912 Cys Ala Ser His Leu Thr Ala Val Thr Ile Phe Tyr Gly Thr Leu Ser 290 295 300 tac atg tat ttg cag tct cat tct aat aat tcc cag gaa aat atg aaa 960 Tyr Met Tyr Leu Gln Ser His Ser Asn Asn Ser Gln Glu Asn Met Lys 305 310 315 320 gtg gcc ttt ata ttt tat ggc aca gtt att ccc atg tta aat cct tta 1008 Val Ala Phe Ile Phe Tyr Gly Thr Val Ile Pro Met Leu Asn Pro Leu 325 330 335 atc tat agc ttg aga aat aag gaa gta aaa gaa gct tta aaa gtg ata 1056 Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Glu Ala Leu Lys Val Ile 340 345 350 ggg aaa aag tta ttt taa 1074 Gly Lys Lys Leu Phe 355 <210> 394 <211> 357 <212> PRT <213> Homo sapiens <400> 394 Met Asn Asn Thr Ile Val Phe Val Ile Lys Ile Gln Ile Glu Lys Ser 1 5 10 15 Asp Leu Lys Tyr Arg Ala Ile Ser Leu Gln Glu Ile Ser Lys Ile Ser 20 25 30 Leu Leu Phe Trp Val Leu Leu Leu Val Ile Ser Arg Leu Leu Leu Ala 35 40 45 Met Thr Leu Gly Asn Ser Thr Glu Val Thr Glu Phe Tyr Leu Leu Gly 50 55 60 Phe Gly Ala Gln His Glu Phe Trp Cys Ile Leu Phe Ile Val Phe Leu 65 70 75 80 Leu Ile Tyr Val Thr Ser Ile Met Gly Asn Ser Gly Ile Ile Leu Leu 85 90 95 Ile Asn Thr Asp Ser Arg Phe Gln Thr Leu Thr Tyr Phe Phe Leu Gln 100 105 110 His Leu Ala Phe Val Asp Ile Cys Tyr Thr Ser Ala Ile Thr Pro Lys 115 120 125 Met Leu Gln Ser Phe Thr Glu Glu Lys Asn Leu Ile Leu Phe Gln Gly 130 135 140 Cys Val Ile Gln Phe Leu Val Tyr Ala Thr Phe Ala Thr Ser Asp Cys 145 150 155 160 Tyr Leu Leu Ala Met Met Ala Val Asp Pro Tyr Val Ala Ile Cys Lys 165 170 175 Pro Leu His Tyr Thr Val Ile Met Ser Arg Thr Val Cys Ile Arg Leu 180 185 190 Val Ala Gly Ser Tyr Ile Met Gly Ser Ile Asn Ala Ser Val Gln Thr 195 200 205 Gly Phe Thr Cys Ser Leu Ser Phe Cys Lys Ser Asn Ser Ile Asn His 210 215 220 Phe Phe Cys Asp Val Pro Pro Ile Leu Ala Leu Ser Cys Ser Asn Val 225 230 235 240 Asp Ile Asn Ile Met Leu Leu Val Val Phe Val Gly Ser Asn Leu Ile 245 250 255 Phe Thr Gly Leu Val Val Ile Phe Ser Tyr Ile Tyr Ile Met Ala Thr 260 265 270 Ile Leu Lys Met Ser Ser Ser Ala Gly Arg Lys Lys Ser Phe Ser Thr 275 280 285 Cys Ala Ser His Leu Thr Ala Val Thr Ile Phe Tyr Gly Thr Leu Ser 290 295 300 Tyr Met Tyr Leu Gln Ser His Ser Asn Asn Ser Gln Glu Asn Met Lys 305 310 315 320 Val Ala Phe Ile Phe Tyr Gly Thr Val Ile Pro Met Leu Asn Pro Leu 325 330 335 Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Glu Ala Leu Lys Val Ile 340 345 350 Gly Lys Lys Leu Phe 355 <210> 395 <211> 933 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(933) <400> 395 atg gca gcc aaa aac tct tct gtg aca gag ttt atc ctc gaa ggc tta 48 Met Ala Ala Lys Asn Ser Ser Val Thr Glu Phe Ile Leu Glu Gly Leu 1 5 10 15 acc cac cag ccg gga ctg cgg atc ccc ctc ttc ttc ctg ttt ctg ggt 96 Thr His Gln Pro Gly Leu Arg Ile Pro Leu Phe Phe Leu Phe Leu Gly 20 25 30 ttc tac acg gtc acc gtg gtg ggg aac ctg ggc ttg ata acc ctg att 144 Phe Tyr Thr Val Thr Val Val Gly Asn Leu Gly Leu Ile Thr Leu Ile 35 40 45 ggg ctg aac tct cac ctg cac act ccc atg tac ttc ttc ctt ttt aac 192 Gly Leu Asn Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Phe Asn 50 55 60 ctc tct tta ata gat ttc tgt ttc tcc act acc atc act ccc aaa atg 240 Leu Ser Leu Ile Asp Phe Cys Phe Ser Thr Thr Ile Thr Pro Lys Met 65 70 75 80 ctg atg agt ttt gtc tca agg aag aac atc att tcc ttc aca ggg tgt 288 Leu Met Ser Phe Val Ser Arg Lys Asn Ile Ile Ser Phe Thr Gly Cys 85 90 95 atg act cag ctc ttc ttc ttc tgc ttc ttt gtc gtc tct gag tcc ttc 336 Met Thr Gln Leu Phe Phe Phe Cys Phe Phe Val Val Ser Glu Ser Phe 100 105 110 atc ctg tca gcg atg gcg tat gac cgc tac gtg gcc atc tgt aac cca 384 Ile Leu Ser Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn Pro 115 120 125 ctg ttg tac aca gtc acc atg tct tgc cag gtg tgt ttg ctc ctt ttg 432 Leu Leu Tyr Thr Val Thr Met Ser Cys Gln Val Cys Leu Leu Leu Leu 130 135 140 ttg ggt gcc tat ggg atg ggg ttt gct ggg gcc atg gcc cac aca gga 480 Leu Gly Ala Tyr Gly Met Gly Phe Ala Gly Ala Met Ala His Thr Gly 145 150 155 160 agc ata atg aac ctg acc ttc tgt gct gac aac ctt gtc aat cat ttc 528 Ser Ile Met Asn Leu Thr Phe Cys Ala Asp Asn Leu Val Asn His Phe 165 170 175 atg tgt gac atc ctt cct ctc ctt gag ctc tcc tgc aac agc tct tac 576 Met Cys Asp Ile Leu Pro Leu Leu Glu Leu Ser Cys Asn Ser Ser Tyr 180 185 190 atg aat gag ctg gtg gtc ttt att gtg gtg gct gtt gac gtt gga atg 624 Met Asn Glu Leu Val Val Phe Ile Val Val Ala Val Asp Val Gly Met 195 200 205 ccc att gtc act gtc ttt att tct tat gcc ctc atc ctc tcc agc att 672 Pro Ile Val Thr Val Phe Ile Ser Tyr Ala Leu Ile Leu Ser Ser Ile 210 215 220 cta cac aac agt tct aca gaa ggc agg tcc aaa gcc ttt agt act tgc 720 Leu His Asn Ser Ser Thr Glu Gly Arg Ser Lys Ala Phe Ser Thr Cys 225 230 235 240 agt tcc cac ata att gta gtt tct ctt ttc ttt ggt tct ggt gct ttc 768 Ser Ser His Ile Ile Val Val Ser Leu Phe Phe Gly Ser Gly Ala Phe 245 250 255 atg tat ctc aaa ccc ctt tcc atc ctg ccc ctc gag caa ggg aaa gtg 816 Met Tyr Leu Lys Pro Leu Ser Ile Leu Pro Leu Glu Gln Gly Lys Val 260 265 270 tcc tcc ctg ttc tat acc ata ata gtc ccc gtg tta aac cca tta atc 864 Ser Ser Leu Phe Tyr Thr Ile Ile Val Pro Val Leu Asn Pro Leu Ile 275 280 285 tat agc ttg agg aac aag gat gtc aaa gtt gcc ctg agg aga act ttg 912 Tyr Ser Leu Arg Asn Lys Asp Val Lys Val Ala Leu Arg Arg Thr Leu 290 295 300 ggc aga aaa atc ttt tct taa 933 Gly Arg Lys Ile Phe Ser 305 310 <210> 396 <211> 310 <212> PRT <213> Homo sapiens < 400> 396 Met Ala Ala Lys Asn Ser Ser Val Thr Glu Phe Ile Leu Glu Gly Leu 1 5 10 15 Thr His Gln Pro Gly Leu Arg Ile Pro Leu Phe Phe Leu Phe Leu Gly 20 25 30 Phe Tyr Thr Val Thr Val Val Gly Asn Leu Gly Leu Ile Thr Leu Ile 35 40 45 Gly Leu Asn Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Phe Asn 50 55 60 Leu Ser Leu Ile Asp Phe Cys Phe Ser Thr Thr Ile Thr Pro Lys Met 65 70 75 80 Leu Met Ser Phe Val Ser Arg Lys Asn Ile Ile Ser Phe Thr Gly Cys 85 90 95 Met Thr Gln Leu Phe Phe Phe Cys Phe Phe Val Val Ser Glu Ser Phe 100 105 110 Ile Leu Ser Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn Pro 115 120 125 Leu Leu Tyr Thr Val Thr Met Ser Cys Gln Val Cys Leu Leu Leu Leu 130 135 140 Leu Gly Ala Tyr Gly Met Gly Phe Ala Gly Ala Met Ala His Thr Gly 145 150 155 160 Ser Ile Met Asn Leu Thr Phe Cys Ala Asp Asn Leu Val Asn His Phe 165 170 175 Met Cys Asp Ile Leu Pro Leu Leu Glu Leu Ser Cys Asn Ser Ser Tyr 180 185 190 Met Asn Glu Leu Val Val Phe Ile Val Val Ala Val Asp Val Gly Met 195 200 205 Pro Ile Val Thr Val Phe Ile Ser Tyr Ala Leu Ile Leu Ser Ser Ile 210 215 220 Leu His Asn Ser Ser Thr Glu Gly Arg Ser Lys Ala Phe Ser Thr Cys 225 230 235 240 Ser Ser His Ile Ile Val Val Ser Leu Phe Phe Gly Ser Gly Ala Phe 245 250 255 Met Tyr Leu Lys Pro Leu Ser Ile Leu Pro Leu Glu Gln Gly Lys Val 260 265 270 Ser Ser Leu Phe Tyr Thr Ile Ile Val Pro Val Leu Asn Pro Leu Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Asp Val Lys Val Ala Leu Arg Arg Thr Leu 290 295 300 Gly Arg Lys Ile Phe Ser 305 310 <210> 397 <211> 942 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(942) <400> 397 atg aca atg gct gct gag aat tcc tcc ttc gtg aca cag ttt atc ctc 48 Met Thr Met Ala Ala Glu Asn Ser Ser Phe Val Thr Gln Phe Ile Leu 1 5 10 15 gca ggc tta act gac caa ccg gga gtc cag atc ccc ctc ttc ttc ctg 96 Ala Gly Leu Thr Asp Gln Pro Gly Val Gln Ile Pro Leu Phe Phe Leu 20 25 30 ttt cta ggc ttc tac gtg gtc act gtg gtg ggg aac ctg ggc ttg ata 144 Phe Leu Gly Phe Tyr Val Val Thr Val Val Gly Asn Leu Gly Leu Ile 35 40 45 acc ctg ata agg ctc aac tct cac ttg cac acc cct atg tac ttc ttc 192 Thr Leu Ile Arg Leu Asn Ser His Leu His Thr Pro Met Tyr Phe Phe 50 55 60 ctc tat aac ttg tcc ttc ata gat ttc tgc tat tcc agt gtt atc act 240 Leu Tyr Asn Leu Ser Phe Ile Asp Phe Cys Tyr Ser Ser Val Ile Thr 65 70 75 80 ccc aaa atg ctg atg agc ttt gtc tta aag aag aac agc atc tcc tac 288 Pro Lys Met Leu Met Ser Phe Val Leu Lys Lys Asn Ser Ile Ser Tyr 85 90 95 gca ggg tgt atg act cag ctc ttc ttc ttt ctt ttc ttt gtt gtc tct 336 Ala Gly Cys Met Thr Gln Leu Phe Phe Phe Leu Phe Phe Val Val Ser 100 105 110 gag tcc ttc atc ctg tca gca atg gcg tat gac cgc tat gtg gcc atc 384 Glu Ser Phe Ile Leu Ser Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile 115 120 125 tgt aac cca ctg ttg tac atg gtc acc atg tct ccc cag gtg tgt ttt 432 Cys Asn Pro Leu Leu Tyr Met Val Thr Met Ser Pro Gln Val Cys Phe 130 135 140 ctc ctt ttg ttg ggt gtc tat ggg atg ggg ttt gct ggg gcc atg gcc 480 Leu Leu Leu Leu Gly Val Tyr Gly Met Gly Phe Ala Gly Ala Met Ala 145 150 155 160 cac aca gcg tgc atg atg ggt gtg acc ttc tgt gcc aat aac ctt gtc 528 His Thr Ala Cys Met Met Gly Val Thr Phe Cys Ala Asn Asn Leu Val 165 170 175 aac cac tac atg tgt gac atc ctt ccc ctt ctt gag tgt gct tgc acc 576 Asn His Tyr Met Cys Asp Ile Leu Pro Leu Leu Glu Cys Ala Cys Thr 180 185 190 agc acc tat gtg aat gag ctt gta gtg ttt gtt gtt gtg ggc att gat 624 Ser Thr Tyr Val Asn Glu Leu Val Val Phe Val Val Val Gly Ile Asp 195 200 205 att ggt gtg ccc aca gtc acc atc ttc att tcc tat gct ctc att ctc 672 Ile Gly Val Pro Thr Val Thr Ile Phe Ile Ser Tyr Ala Leu Ile Leu 210 215 220 tcc agc atc ttc cac att gat tcc acg gag ggc agg tcc aaa gcc ttc 720 Ser Ser Ile Phe His Ile Asp Ser Thr Glu Gly Arg Ser Lys Ala Phe 225 230 235 240 agc acc tgc agc tcc cac ata att gca gtt tct ctg ttc ttt ggg tca 768 Ser Thr Cys Ser Ser His Ile Ile Ala Val Ser Leu Phe Phe Gly Ser 245 250 255 gga gca ttc atg tac ctc aaa ccc ttt tct ctt tta gct atg aac cag 816 Gly Ala Phe Met Tyr Leu Lys Pro Phe Ser Leu Leu Ala Met Asn Gln 260 265 270 ggc aag gtg tct tcc cta ttc tat acc act gtg gtg ccc atg ctc aac 864 Gly Lys Val Ser Ser Leu Phe Tyr Thr Thr Val Val Pro Met Leu Asn 275 280 285 cca tta att tat agc ctg agg aat aag gac gtc aaa gtt gct cta aag 912 Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Val Ala Leu Lys 290 295 300 aaa atc ttg aac aaa aat gca ttc tcc tga 942 Lys Ile Leu Asn Lys Asn Ala Phe Ser 305 310 <210> 398 <211> 313 <212> PRT <213> Homo sapiens <400> 398 Met Thr Met Ala Ala Glu Asn Ser Ser Phe Val Thr Gln Phe Ile Leu 1 5 10 15 Ala Gly Leu Thr Asp Gln Pro Gly Val Gln Ile Pro Leu Phe Phe Leu 20 25 30 Phe Leu Gly Phe Tyr Val Val Thr Val Val Gly Asn Leu Gly Leu Ile 35 40 45 Thr Leu Ile Arg Leu Asn Ser His Leu His Thr Pro Met Tyr Phe Phe 50 55 60 Leu Tyr Asn Leu Ser Phe Ile Asp Phe Cys Tyr Ser Ser Val Ile Thr 65 70 75 80 Pro Lys Met Leu Met Ser Phe Val Leu Lys Lys Asn Ser Ile Ser Tyr 85 90 95 Ala Gly Cys Met Thr Gln Leu Phe Phe Phe Leu Phe Phe Val Val Ser 100 105 110 Glu Ser Phe Ile Leu Ser Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile 115 120 125 Cys Asn Pro Leu Leu Tyr Met Val Thr Met Ser Pro Gln Val Cys Phe 130 135 140 Leu Leu Leu Leu Gly Val Tyr Gly Met Gly Phe Ala Gly Ala Met Ala 145 150 155 160 His Thr Ala Cys Met Met Gly Val Thr Phe Cys Ala Asn Asn Leu Val 165 170 175 Asn His Tyr Met Cys Asp Ile Leu Pro Leu Leu Glu Cys Ala Cys Thr 180 185 190 Ser Thr Tyr Val Asn Glu Leu Val Val Phe Val Val Val Gly Ile Asp 195 200 205 Ile Gly Val Pro Thr Val Thr Ile Phe Ile Ser Tyr Ala Leu Ile Leu 210 215 220 Ser Ser Ile Phe His Ile Asp Ser Thr Glu Gly Arg Ser Lys Ala Phe 225 230 235 240 Ser Thr Cys Ser Ser His Ile Ile Ala Val Ser Leu Phe Phe Gly Ser 245 250 255 Gly Ala Phe Met Tyr Leu Lys Pro Phe Ser Leu Leu Ala Met Asn Gln 260 265 270 Gly Lys Val Ser Ser Leu Phe Tyr Thr Thr Val Val Pro Met Leu Asn 275 280 285 Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Val Ala Leu Lys 290 295 300 Lys Ile Leu Asn Lys Asn Ala Phe Ser 305 310 <210> 399 <211> 930 < 212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(930) <400> 399 atg act ctg aga aac agc tcc tca gtg act gag ttt atc ctt gtg gga 48 Met Thr Leu Arg Asn Ser Ser Ser Val Thr Glu Phe Ile Leu Val Gly 1 5 10 15 tta tca gaa cag cca gag ctc cag ctc cct ctt ttc ctt cta ttc tta 96 Leu Ser Glu Gln Pro Glu Leu Gln Leu Pro Leu Phe Leu Leu Phe Leu 20 25 30 ggg atc tat gtg ttc act gtg gtg ggc aac ttg ggc ttg atc acc tta 144 Gly Ile Tyr Val Phe Thr Val Val Gly Asn Leu Gly Leu Ile Thr Leu 35 40 45 att ggg ata aat cct agc ctt cac acc ccc atg tac ttt ttc ctc ttc 192 Ile Gly Ile Asn Pro Ser Leu His Thr Pro Met Tyr Phe Phe Leu Phe 50 55 60 aac ttg tcc ttt ata gat ctc tgt tat tcc tgt gtg ttt acc ccc aaa 240 Asn Leu Ser Phe Ile Asp Leu Cys Tyr Ser Cys Val Phe Thr Pro Lys 65 70 75 80 atg ctg aat gac ttt gtt tca gaa agt atc atc tct tat gtg gga tgt 288 Met Leu Asn Asp Phe Val Ser Glu Ser Ile Ile Ser Tyr Val Gly Cys 85 90 95 atg act cag cta ttt ttc ttc tgt ttc ttt gtc aat tct gag tgc tat 336 Met Thr Gln Leu Phe Phe Phe Cys Phe Phe Val Asn Ser Glu Cys Tyr 100 105 110 gtg ttg gta tca atg gcc tat gat cgc tat gtg gcc atc tgc aac ccc 384 Val Leu Val Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn Pro 115 120 125 ctg ctc tac atg gtc acc atg tcc cca agg gtc tgc ttt ctg ctg atg 432 Leu Leu Tyr Met Val Thr Met Ser Pro Arg Val Cys Phe Leu Leu Met 130 135 140 ttt ggt tcc tat gtg gta ggg ttt gct ggg gcc atg gcc cac act gga 480 Phe Gly Ser Tyr Val Val Gly Phe Ala Gly Ala Met Ala His Thr Gly 145 150 155 160 agc atg ctg cga ctg acc ttc tgt gat tcc aac gtc att gac cat tat 528 Ser Met Leu Arg Leu Thr Phe Cys Asp Ser Asn Val Ile Asp His Tyr 165 170 175 ctg tgt gac gtt ctc ccc ctc ttg cag ctc tcc tgc acc agc acc cat 576 Leu Cys Asp Val Leu Pro Leu Leu Gln Leu Ser Cys Thr Ser Thr His 180 185 190 gtc agt gag ctg gta ttt ttc att gtt gtt gga gta atc acc atg cta 624 Val Ser Glu Leu Val Phe Phe Ile Val Val Gly Val Ile Thr Met Leu 195 200 205 tcc agc ata agc atc gtc atc tct tac gct ttg ata ctc tcc aac atc 672 Ser Ser Ile Ser Ile Val Ile Ser Tyr Ala Leu Ile Leu Ser Asn Ile 210 215 220 ctc tgt att cct tct gca gag ggc aga tcc aaa gcc ttt agc aca tgg 720 Leu Cys Ile Pro Ser Ala Glu Gly Arg Ser Lys Ala Phe Ser Thr Trp 225 230 235 240 ggc tcc cac ata att gct gtt gct ctg ttt ttt ggg tca ggg aca ttc 768 Gly Ser His Ile Ile Ala Val Ala Leu Phe Phe Gly Ser Gly Thr Phe 245 250 255 acc tac tta aca aca tct ttt cct ggc tct atg aac cat ggc aga ttt 816 Thr Tyr Leu Thr Thr Ser Phe Pro Gly Ser Met Asn His Gly Arg Phe 260 265 270 gcc tca gtc ttt tac acc aat gtg gtt ccc atg ctt aac cct tcg atc 864 Ala Ser Val Phe Tyr Thr Asn Val Val Pro Met Leu Asn Pro Ser Ile 275 280 285 tac agt ttg agg aat aag gat gat aaa ctt gcc ctg ggc aaa acc ctg 912 Tyr Ser Leu Arg Asn Lys Asp Asp Lys Leu Ala Leu Gly Lys Thr Leu 290 295 300 aag aga gtg ctc ttc taa 930 Lys Arg Val Leu Phe 305 310 <210> 400 <211> 309 <212> PRT <213> Homo sapiens <40 0> 400 Met Thr Leu Arg Asn Ser Ser Ser Val Thr Glu Phe Ile Leu Val Gly 1 5 10 15 Leu Ser Glu Gln Pro Glu Leu Gln Leu Pro Leu Phe Leu Leu Phe Leu 20 25 30 Gly Ile Tyr Val Phe Thr Val Val Gly Asn Leu Gly Leu Ile Thr Leu 35 40 45 Ile Gly Ile Asn Pro Ser Leu His Thr Pro Met Tyr Phe Phe Leu Phe 50 55 60 Asn Leu Ser Phe Ile Asp Leu Cys Tyr Ser Cys Val Phe Thr Pro Lys 65 70 75 80 Met Leu Asn Asp Phe Val Ser Glu Ser Ile Ile Ser Tyr Val Gly Cys 85 90 95 Met Thr Gln Leu Phe Phe Phe Cys Phe Phe Val Asn Ser Glu Cys Tyr 100 105 110 Val Leu Val Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn Pro 115 120 125 Leu Leu Tyr Met Val Thr Met Ser Pro Arg Val Cys Phe Leu Leu Met 130 135 140 Phe Gly Ser Tyr Val Val Gly Phe Ala Gly Ala Met Ala His Thr Gly 145 150 155 160 Ser Met Leu Arg Leu Thr Phe Cys Asp Ser Asn Val Ile Asp His Tyr 165 170 175 Leu Cys Asp Val Leu Pro Leu Leu Gln Leu Ser Cys Thr Ser Thr His 180 185 190 Val Ser Glu Leu Val Phe Phe Ile Val Val Gly Val Ile Thr Met Leu 195 200 205 Ser Ser Ile Ser Ile Val Ile Ser Tyr Ala Leu Ile Leu Ser Asn Ile 210 215 220 Leu Cys Ile Pro Ser Ala Glu Gly Arg Ser Lys Ala Phe Ser Thr Trp 225 230 235 240 Gly Ser His Ile Ile Ala Val Ala Leu Phe Phe Gly Ser Gly Thr Phe 245 250 255 Thr Tyr Leu Thr Thr Ser Phe Pro Gly Ser Met Asn His Gly Arg Phe 260 265 270 Ala Ser Val Phe Tyr Thr Asn Val Val Pro Met Leu Asn Pro Ser Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Asp Asp Lys Leu Ala Leu Gly Lys Thr Leu 290 295 300 Lys Arg Val Leu Phe 305 <210> 401 <211> 936 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(936) <400> 401 atg gct act tca aac cat tct tca ggg gct gag ttt atc ctg gca ggc 48 Met Ala Thr Ser Asn His Ser Ser Gly Ala Glu Phe Ile Leu Ala Gly 1 5 10 15 ttg aca caa cgc cca gaa ctt caa ctg cca ctc ttc ctc ctg ttc ctt 96 Leu Thr Gln Arg Pro Glu Leu Gln Leu Pro Leu Phe Leu Leu Phe Leu 20 25 30 gga ata tat gtg gtc aca gtg gtg ggg aac ctg ggc atg atc ttc tta 144 Gly Ile Tyr Val Val Thr Val Val Gly Asn Leu Gly Met Ile Phe Leu 35 40 45 att gct ctc agt tct caa ctt tac cct cca gtg tat tat ttt ctc agt 192 Ile Ala Leu Ser Ser Gln Leu Tyr Pro Pro Val Tyr Tyr Phe Leu Ser 50 55 60 cat ttg tct ttc att gat ctc tgc tac tcc tct gtc att acc cct aag 240 His Leu Ser Phe Ile Asp Leu Cys Tyr Ser Ser Val Ile Thr Pro Lys 65 70 75 80 atg ctg gtg aac ttt gtt cca gag gag aac att atc tcc ttt ctg gaa 288 Met Leu Val Asn Phe Val Pro Glu Glu Asn Ile Ile Ser Phe Leu Glu 85 90 95 tgc att act caa ctt tat ttc ttc ctt att ttt gta att gca gaa ggc 336 Cys Ile Thr Gln Leu Tyr Phe Phe Leu Ile Phe Val Ile Ala Glu Gly 100 105 110 tac ctt ctg aca gcc atg gaa tat gac cgt tat gtt gct atc tgt cgc 384 Tyr Leu Leu Thr Ala Met Glu Tyr Asp Arg Tyr Val Ala Ile Cys Arg 115 120 125 cca ctg ctt tac aat att gtc atg tcc cac agg gtc tgt tcc ata atg 432 Pro Leu Leu Tyr Asn Ile Val Met Ser His Arg Val Cys Ser Ile Met 130 135 140 atg gct gtg gta tac tca ctg ggt ttt ctg tgg gcc aca gtc cat act 480 Met Ala Val Val Tyr Ser Leu Gly Phe Leu Trp Ala Thr Val His Thr 145 150 155 160 acc cgc atg tca gtg ttg tca ttc tgt agg tct cat acg gtc agt cat 528 Thr Arg Met Ser Val Leu Ser Phe Cys Arg Ser His Thr Val Ser His 165 170 175 tat ttt tgt gat att ctc ccc tta ttg act ctg tct tgc tcc agc acc 576 Tyr Phe Cys Asp Ile Leu Pro Leu Leu Thr Leu Ser Cys Ser Ser Thr 180 185 190 cac atc aat gag att ctg ctg ttc att att gga gga gtt aat acc tta 624 His Ile Asn Glu Ile Leu Leu Phe Ile Ile Gly Gly Val Asn Thr Leu 195 200 205 gca act aca ctg gcg gtc ctt atc tct tat gct ttc att ttc tct agt 672 Ala Thr Thr Leu Ala Val Leu Ile Ser Tyr Ala Phe Ile Phe Ser Ser 210 215 220 atc ctt ggt att cat tcc act gag ggg caa tcc aaa gcc ttt ggc act 720 Ile Leu Gly Ile His Ser Thr Glu Gly Gln Ser Lys Ala Phe Gly Thr 225 230 235 240 tgt agc tcc cat ctc ttg gct gtg ggc atc ttt ttt ggg tct ata aca 768 Cys Ser Ser His Leu Leu Ala Val Gly Ile Phe Phe Gly Ser Ile Thr 245 250 255 ttc atg tat ttc aag ccc cct tcc agc act act atg gaa aaa gag aag 816 Phe Met Tyr Phe Lys Pro Pro Ser Ser Thr Thr Met Glu Lys Glu Lys 260 265 270 gtg tct tct gtg ttc tac atc aca ata atc ccc atg ctg aat cct cta 864 Val Ser Ser Val Phe Tyr Ile Thr Ile Ile Pro Met Leu Asn Pro Leu 275 280 285 atc tat agc ctg agg aac aag gat gtg aaa aat gca ctg aag aag atg 912 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Asn Ala Leu Lys Lys Met 290 295 300 act agg gga agg cag tca tcc tga 936 Thr Arg Gly Arg Gln Ser Ser 305 310 <210> 402 <211> 311 <212> PRT <213> Homo sapiens <400> 402 Met Ala Thr Ser Asn His Ser Ser Gly Ala Glu Phe Ile Leu Ala Gly 1 5 10 15 Leu Thr Gln Arg Pro Glu Leu Gln Leu Pro Leu Phe Leu Leu Phe Leu 20 25 30 Gly Ile Tyr Val Val Thr Val Val Gly Asn Leu Gly Met Ile Phe Leu 35 40 45 Ile Ala Leu Ser Ser Gln Leu Tyr Pro Pro Val Tyr Tyr Phe Leu Ser 50 55 60 His Leu Ser Phe Ile Asp Leu Cys Tyr Ser Ser Val Ile Thr Pro Lys 65 70 75 80 Met Leu Val Asn Phe Val Pro Glu Glu Asn Ile Ile Ser Phe Leu Glu 85 90 95 Cys Ile Thr Gln Leu Tyr Phe Phe Leu Ile Phe Val Ile Ala Glu Gly 100 105 110 Tyr Leu Leu Thr Ala Met Glu Tyr Asp Arg Tyr Val Ala Ile Cys Arg 115 120 125 Pro Leu Leu Tyr Asn Ile Val Met Ser His Arg Val Cys Ser Ile Met 130 135 140 Met Ala Val Val Tyr Ser Leu Gly Phe Leu Trp Ala Thr Val His Thr 145 150 155 160 Thr Arg Met Ser Val Leu Ser Phe Cys Arg Ser His Thr Val Ser His 165 170 175 Tyr Phe Cys Asp Ile Leu Pro Leu Leu Thr Leu Ser Cys Ser Ser Thr 180 185 190 His Ile Asn Glu Ile Leu Leu Phe Ile Ile Gly Gly Val Asn Thr Leu 195 200 205 Ala Thr Thr Leu Ala Val Leu Ile Ser Tyr Ala Phe Ile Phe Ser Ser 210 215 220 Ile Leu Gly Ile His Ser Thr Glu Gly Gln Ser Lys Ala Phe Gly Thr 225 230 235 240 Cys Ser Ser His Leu Leu Ala Val Gly Ile Phe Phe Gly Ser Ile Thr 245 250 255 Phe Met Tyr Phe Lys Pro Pro Ser Ser Thr Thr Met Glu Lys Glu Lys 260 265 270 Val Ser Ser Val Phe Tyr Ile Thr Ile Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Asn Ala Leu Lys Lys Met 290 295 300 Thr Arg Gly Arg Gln Ser Ser 305 310 <210> 403 <211> 942 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(942) <400> 403 atg ctg gct aga aac aac tcc tta gtg act gaa ttt att ctt gct gga 48 Met Leu Ala Arg Asn Asn Ser Leu Val Thr Glu Phe Ile Leu Ala Gly 1 5 10 15 tta aca gat cgt cca gag ttc tgg caa ccc ttc ttt ttc ctg ttc cta 96 Leu Thr Asp Arg Pro Glu Phe Trp Gln Pro Phe Phe Phe Leu Phe Leu 20 25 30 gtg atc tac att gtc acc atg gta ggc aac ctt ggc ttg atc act ctt 144 Val Ile Tyr Ile Val Thr Met Val Gly Asn Leu Gly Leu Ile Thr Leu 35 40 45 ttc ggt cta aat tct cac ctc cac aca cca atg tac tat ttc ctc ttc 192 Phe Gly Leu Asn Ser His Leu His Thr Pro Met Tyr Tyr Phe Leu Phe 50 55 60 aat ctc tcc ttc att gat ctc tgt tac tcc tct gtt ttc act ccc aaa 240 Asn Leu Ser Phe Ile Asp Leu Cys Tyr Ser Ser Val Phe Thr Pro Lys 65 70 75 80 atg cta atg aac ttt gtg tca aaa aag aat att atc tcc aat gtt ggg 288 Met Leu Met Asn Phe Val Ser Lys Lys Asn Ile Ile Ser Asn Val Gly 85 90 95 tgc atg act cgg ctg ttt ttc ttt ctc ttt ttc gtc atc tct gaa tgt 336 Cys Met Thr Arg Leu Phe Phe Phe Leu Phe Phe Val Ile Ser Glu Cys 100 105 110 tac atg ttg acc tca atg gca tat gat cgc tat gtg gcc atc tgt aat 384 Tyr Met Leu Thr Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 cca ttg ctg tat aag gtc acc atg tcc cat cag gtc tgt tct atg ctc 432 Pro Leu Leu Tyr Lys Val Thr Met Ser His Gln Val Cys Ser Met Leu 130 135 140 act ttt gct gct tac ata atg gga ttg gct gga gcc acg gcc cac acc 480 Thr Phe Ala Ala Tyr Ile Met Gly Leu Ala Gly Ala Thr Ala His Thr 145 150 155 160 ggg tgc atg ttt aga ctc acc ttc tgc agt gct aat atc att aac cat 528 Gly Cys Met Phe Arg Leu Thr Phe Cys Ser Ala Asn Ile Ile Asn His 165 170 175 tac ttg tgt gac ata ctc ccc ctc ctc cag ctt tcc tgc acc agc acc 576 Tyr Leu Cys Asp Ile Leu Pro Leu Leu Gln Leu Ser Cys Thr Ser Thr 180 185 190 tat gtc aac gag gtg gtt gtt ctc att gtt gtg ggt act aat atc acg 624 Tyr Val Asn Glu Val Val Val Leu Ile Val Val Gly Thr Asn Ile Thr 195 200 205 gta ccc agt tgt acc atc ctc att tct tat gtt ttc att gtc act agc 672 Val Pro Ser Cys Thr Ile Leu Ile Ser Tyr Val Phe Ile Val Thr Ser 210 215 220 att ctt cat atc aaa tcc act caa gga aga tca aaa gcc ttc agt act 720 Ile Leu His Ile Lys Ser Thr Gln Gly Arg Ser Lys Ala Phe Ser Thr 225 230 235 240 tgt agc tct cat gtc att gct ctg tct ctg ttt ttt ggg tca gcg gca 768 Cys Ser Ser His Val Ile Ala Leu Ser Leu Phe Phe Gly Ser Ala Ala 245 250 255 ttc atg tat att aaa tat tct tct gga tct atg gag cag gga aaa gtt 816 Phe Met Tyr Ile Lys Tyr Ser Ser Gly Ser Met Glu Gln Gly Lys Val 260 265 270 ttt tct gtt ttc tac act aat gtg gtg ccc atg ctc aat ccc ctc atc 864 Phe Ser Val Phe Tyr Thr Asn Val Val Pro Met Leu Asn Pro Leu Ile 275 280 285 tac agt ttg agg aac aag gat gtc aaa gtt gca ctg agg aaa gct ctg 912 Tyr Ser Leu Arg Asn Lys Asp Val Lys Val Ala Leu Arg Lys Ala Leu 290 295 300 att aaa att cag agg aga aat ata ttc taa 942 Ile Lys Ile Gln Arg Arg Asn Ile Phe 305 310 <210> 404 <211> 313 <212> PRT <213> Homo sapiens <400> 404 Met Leu Ala Arg Asn Asn Ser Leu Val Thr Glu Phe Ile Leu Ala Gly 1 5 10 15 Leu Thr Asp Arg Pro Glu Phe Trp Gln Pro Phe Phe Phe Leu Phe Leu 20 25 30 Val Ile Tyr Ile Val Thr Met Val Gly Asn Leu Gly Leu Ile Thr Leu 35 40 45 Phe Gly Leu Asn Ser His Leu His Thr Pro Met Tyr Tyr Phe Leu Phe 50 55 60 Asn Leu Ser Phe Ile Asp Leu Cys Tyr Ser Ser Val Phe Thr Pro Lys 65 70 75 80 Met Leu Met Asn Phe Val Ser Lys Lys Asn Ile Ile Ser Asn Val Gly 85 90 95 Cys Met Thr Arg Leu Phe Phe Phe Leu Phe Phe Val Ile Ser Glu Cys 100 105 110 Tyr Met Leu Thr Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Lys Val Thr Met Ser His Gln Val Cys Ser Met Leu 130 135 140 Thr Phe Ala Ala Tyr Ile Met Gly Leu Ala Gly Ala Thr Ala His Thr 145 150 155 160 Gly Cys Met Phe Arg Leu Thr Phe Cys Ser Ala Asn Ile Ile Asn His 165 170 175 Tyr Leu Cys Asp Ile Leu Pro Leu Leu Gln Leu Ser Cys Thr Ser Thr 180 185 190 Tyr Val Asn Glu Val Val Val Leu Ile Val Val Gly Thr Asn Ile Thr 195 200 205 Val Pro Ser Cys Thr Ile Leu Ile Ser Tyr Val Phe Ile Val Thr Ser 210 215 220 Ile Leu His Ile Lys Ser Thr Gln Gly Arg Ser Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Val Ile Ala Leu Ser Leu Phe Phe Gly Ser Ala Ala 245 250 255 Phe Met Tyr Ile Lys Tyr Ser Ser Gly Ser Met Glu Gln Gly Lys Val 260 265 270 Phe Ser Val Phe Tyr Thr Asn Val Val Pro Met Leu Asn Pro Leu Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Asp Val Lys Val Ala Leu Arg Lys Ala Leu 290 295 300 Ile Lys Ile Gln Arg Arg Asn Ile Phe 305 310 <210> 405 <211> 927 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(927) <400> 405 atg acc atg gaa aat tat tct atg gca gct cag ttt gtc tta gat ggt 48 Met Thr Met Glu Asn Tyr Ser Met Ala Ala Gln Phe Val Leu Asp Gly 1 5 10 15 tta aca cag caa gca gag ctc cag ctg ccc ctc ttc ctc ctg ttc ctg 96 Leu Thr Gln Gln Ala Glu Leu Gln Leu Pro Leu Phe Leu Leu Phe Leu 20 25 30 gga atc tat gtg gtc aca gta gtg ggc aac ctg ggc atg att ctc ctg 144 Gly Ile Tyr Val Val Thr Val Val Gly Asn Leu Gly Met Ile Leu Leu 35 40 45 att gca gtc agc cct cta ctt cac acc ccc atg tac tat ttc ctc agc 192 Ile Ala Val Ser Pro Leu Leu His Thr Pro Met Tyr Tyr Phe Leu Ser 50 55 60 agc ttg tcc ttc gtc gat ttc tgc tat tcc tct gtc att act ccc aaa 240 Ser Leu Ser Phe Val Asp Phe Cys Tyr Ser Ser Val Ile Thr Pro Lys 65 70 75 80 atg ctg gtg aac ttc cta gga aag aag aat aca atc ctt tac tct gag 288 Met Leu Val Asn Phe Leu Gly Lys Lys Asn Thr Ile Leu Tyr Ser Glu 85 90 95 tgc atg gtc cag ctc ttt ttc ttt gtg gtc ttt gtg gtg gct gag ggt 336 Cys Met Val Gln Leu Phe Phe Phe Val Val Phe Val Val Ala Glu Gly 100 105 110 tac ctc ctg act gcc atg gca tat gat cgc tat gtt gcc atc tgt agc 384 Tyr Leu Leu Thr Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Ser 115 120 125 cca ctg ctt tat aat gcg atc atg tcc tca tgg gtc tgc tca ctg cta 432 Pro Leu Leu Tyr Asn Ala Ile Met Ser Ser Trp Val Cys Ser Leu Leu 130 135 140 gtg ctg gct gcc ttc ttc ttg ggc ttt ctc tct gcc ttg act cat aca 480 Val Leu Ala Ala Phe Phe Leu Gly Phe Leu Ser Ala Leu Thr His Thr 145 150 155 160 agt gcc atg atg aaa ctg tcc ttt tgc aaa tcc cac att atc aac cat 528 Ser Ala Met Met Lys Leu Ser Phe Cys Lys Ser His Ile Ile Asn His 165 170 175 tac ttc tgt gat gtt ctt ccc ctc ctc aat ctc tcc tgc tcc aac aca 576 Tyr Phe Cys Asp Val Leu Pro Leu Leu Asn Leu Ser Cys Ser Asn Thr 180 185 190 cac ctc aat gag ctt cta ctt ttt atc att gcg ggg ttt aac acc ttg 624 His Leu Asn Glu Leu Leu Leu Phe Ile Ile Ala Gly Phe Asn Thr Leu 195 200 205 gtg ccc acc cta gct gtt gct gtc tcc tat gcc ttc atc ctc tac agc 672 Val Pro Thr Leu Ala Val Ala Val Ser Tyr Ala Phe Ile Leu Tyr Ser 210 215 220 atc ctt cac atc cgc tcc tca gag ggc cgg tcc aaa gct ttt gga aca 720 Ile Leu His Ile Arg Ser Ser Glu Gly Arg Ser Lys Ala Phe Gly Thr 225 230 235 240 tgc agc tct cat ctc atg gct gtg gtg atc ttc ttt ggg tcc att acc 768 Cys Ser Ser His Leu Met Ala Val Val Ile Phe Phe Gly Ser Ile Thr 245 250 255 ttc atg tat ttc aag ccc cct tca agt aac tcc ctg gac cag gag aag 816 Phe Met Tyr Phe Lys Pro Pro Ser Ser Asn Ser Leu Asp Gln Glu Lys 260 265 270 gtg tcc tct gtg ttc tac acc acg gtg atc ccc atg ctg aac cct tta 864 Val Ser Ser Val Phe Tyr Thr Thr Val Ile Pro Met Leu Asn Pro Leu 275 280 285 ata tac agt ctg agg aat aag gat gtg aag aaa gca tta agg aag gtc 912 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Lys Ala Leu Arg Lys Val 290 295 300 tta gta gga aaa tga 927 Leu Val Gly Lys 305 <210> 406 <211> 308 <212> PRT <213> Homo sapiens <400> 406 Met Thr Met Glu Asn Tyr Ser Met Ala Ala Gln Phe Val Leu Asp Gly 1 5 10 15 Leu Thr Gln Gln Ala Glu Leu Gln Leu Pro Leu Phe Leu Leu Phe Leu 20 25 30 Gly Ile Tyr Val Val Thr Val Val Gly Asn Leu Gly Met Ile Leu Leu 35 40 45 Ile Ala Val Ser Pro Leu Leu His Thr Pro Met Tyr Tyr Phe Leu Ser 50 55 60 Ser Leu Ser Phe Val Asp Phe Cys Tyr Ser Ser Val Ile Thr Pro Lys 65 70 75 80 Met Leu Val Asn Phe Leu Gly Lys Lys Asn Thr Ile Leu Tyr Ser Glu 85 90 95 Cys Met Val Gln Leu Phe Phe Phe Val Val Phe Val Val Ala Glu Gly 100 105 110 Tyr Leu Leu Thr Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Ser 115 120 125 Pro Leu Leu Tyr Asn Ala Ile Met Ser Ser Trp Val Cys Ser Leu Leu 130 135 140 Val Leu Ala Ala Phe Phe Leu Gly Phe Leu Ser Ala Leu Thr His Thr 145 150 155 160 Ser Ala Met Met Lys Leu Ser Phe Cys Lys Ser His Ile Ile Asn His 165 170 175 Tyr Phe Cys Asp Val Leu Pro Leu Leu Asn Leu Ser Cys Ser Asn Thr 180 185 190 His Leu Asn Glu Leu Leu Leu Phe Ile Ile Ala Gly Phe Asn Thr Leu 195 200 205 Val Pro Thr Leu Ala Val Ala Val Ser Tyr Ala Phe Ile Leu Tyr Ser 210 215 220 Ile Leu His Ile Arg Ser Ser Glu Gly Arg Ser Lys Ala Phe Gly Thr 225 230 235 240 Cys Ser Ser His Leu Met Ala Val Val Ile Phe Phe Gly Ser Ile Thr 245 250 255 Phe Met Tyr Phe Lys Pro Pro Ser Ser Asn Ser Leu Asp Gln Glu Lys 260 265 270 Val Ser Ser Val Phe Tyr Thr Thr Val Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Lys Ala Leu Arg Lys Val 290 295 300 Leu Val Gly Lys 305 <210> 407 <211> 999 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(999) <400> 407 atg tta gag ggt gtt gag cat ctc ctt ctg cta ctt ctt ttg aca gat 48 Met Leu Glu Gly Val Glu His Leu Leu Leu Leu Leu Leu Leu Thr Asp 1 5 10 15 gtg aac agc aag gaa ctg caa agt gga aac cag act tct gtg tct cac 96 Val Asn Ser Lys Glu Leu Gln Ser Gly Asn Gln Thr Ser Val Ser His 20 25 30 ttc att ttg gtg ggc ctg cac cac cca cca cag ctg gga gcg cca ctc 144 Phe Ile Leu Val Gly Leu His His Pro Pro Gln Leu Gly Ala Pro Leu 35 40 45 ttc tta gct ttc ctt gtc atc tat ctc ctc act gtt tct gga aat ggg 192 Phe Leu Ala Phe Leu Val Ile Tyr Leu Leu Thr Val Ser Gly Asn Gly 50 55 60 ctc atc atc ctc act gtc tta gtg gac atc cgg ctc cat cgt ccc atg 240 Leu Ile Ile Leu Thr Val Leu Val Asp Ile Arg Leu His Arg Pro Met 65 70 75 80 tgc ttg ttc ctg tgt cac ctc tcc ttc ttg gac atg acc att tct tgt 288 Cys Leu Phe Leu Cys His Leu Ser Phe Leu Asp Met Thr Ile Ser Cys 85 90 95 gct att gtc ccc aag atg ctg gct ggc ttt ctc ttg ggt agt agg att 336 Ala Ile Val Pro Lys Met Leu Ala Gly Phe Leu Leu Gly Ser Arg Ile 100 105 110 atc tcc ttt ggg ggc tgt gta atc caa cta ttt tct ttc cat ttc ctg 384 Ile Ser Phe Gly Gly Cys Val Ile Gln Leu Phe Ser Phe His Phe Leu 115 120 125 ggc tgt act gag tgc ttc ctt tac aca ctc atg gct tat gac cgt ttc 432 Gly Cys Thr Glu Cys Phe Leu Tyr Thr Leu Met Ala Tyr Asp Arg Phe 130 135 140 ctt gcc att tgt aag ccc tta cac tat gct acc atc atg acc cac aga 480 Leu Ala Ile Cys Lys Pro Leu His Tyr Ala Thr Ile Met Thr His Arg 145 150 155 160 gtc tgt aac tcc ctg gct tta ggc acc tgg ctg gga ggg act atc cat 528 Val Cys Asn Ser Leu Ala Leu Gly Thr Trp Leu Gly Gly Thr Ile His 165 170 175 tca ctt ttc caa aca agt ttt gta ttc cgg ctg ccc ttc tgt ggc ccc 576 Ser Leu Phe Gln Thr Ser Phe Val Phe Arg Leu Pro Phe Cys Gly Pro 180 185 190 aat cgg gtc gac tac atc ttc tgt gac att cct gcc atg ctg cgt cta 624 Asn Arg Val Asp Tyr Ile Phe Cys Asp Ile Pro Ala Met Leu Arg Leu 195 200 205 gcc tgc gcc gat acg gcc atc aac gag ctg gtc acc ttt gca gac att 672 Ala Cys Ala Asp Thr Ala Ile Asn Glu Leu Val Thr Phe Ala Asp Ile 210 215 220 ggc ttc ctg gcc ctc acc tgc ttc atg ctc atc ctc act tcc tat ggc 720 Gly Phe Leu Ala Leu Thr Cys Phe Met Leu Ile Leu Thr Ser Tyr Gly 225 230 235 240 tat att gta gct gcc atc ctg cga att ccg tca gca gat ggg cgc cgc 768 Tyr Ile Val Ala Ala Ile Leu Arg Ile Pro Ser Ala Asp Gly Arg Arg 245 250 255 aat gcc ttc tcc act tgt gct gcc cac ctc act gtt gtc att gtt tac 816 Asn Ala Phe Ser Thr Cys Ala Ala His Leu Thr Val Val Ile Val Tyr 260 265 270 tat gtg ccc tgc acc ttc att tac ctg cgg cct tgt tca cag gag ccc 864 Tyr Val Pro Cys Thr Phe Ile Tyr Leu Arg Pro Cys Ser Gln Glu Pro 275 280 285 ctg gat ggg gtg gta gct gtc ttt tac act gtc atc act ccc ttg ctt 912 Leu Asp Gly Val Val Ala Val Phe Tyr Thr Val Ile Thr Pro Leu Leu 290 295 300 aac tcc atc atc tac aca ctg tgc aac aaa gaa atg aag gca gca tta 960 Asn Ser Ile Ile Tyr Thr Leu Cys Asn Lys Glu Met Lys Ala Ala Leu 305 310 315 320 cag agg cta ggg ggc cac aag gaa gtg cag cct cac tga 999 Gln Arg Leu Gly Gly His Lys Glu Val Gln Pro His 325 330 <210> 408 <211> 332 <212> PRT <213> Homo sapiens <400> 408 Met Leu Glu Gly Val Glu His Leu Leu Leu Leu Leu Leu Leu Thr Asp 1 5 10 15 Val Asn Ser Lys Glu Leu Gln Ser Gly Asn Gln Thr Ser Val Ser His 20 25 30 Phe Ile Leu Val Gly Leu His His Pro Pro Gln Leu Gly Ala Pro Leu 35 40 45 Phe Leu Ala Phe Leu Val Ile Tyr Leu Leu Thr Val Ser Gly Asn Gly 50 55 60 Leu Ile Ile Leu Thr Val Leu Val Asp Ile Arg Leu His Arg Pro Met 65 70 75 80 Cys Leu Phe Leu Cys His Leu Ser Phe Leu Asp Met Thr Ile Ser Cys 85 90 95 Ala Ile Val Pro Lys Met Leu Ala Gly Phe Leu Leu Gly Ser Arg Ile 100 105 110 Ile Ser Phe Gly Gly Cys Val Ile Gln Leu Phe Ser Phe His Phe Leu 115 120 125 Gly Cys Thr Glu Cys Phe Leu Tyr Thr Leu Met Ala Tyr Asp Arg Phe 130 135 140 Leu Ala Ile Cys Lys Pro Leu His Tyr Ala Thr Ile Met Thr His Arg 145 150 155 160 Val Cys Asn Ser Leu Ala Leu Gly Thr Trp Leu Gly Gly Thr Ile His 165 170 175 Ser Leu Phe Gln Thr Ser Phe Val Phe Arg Leu Pro Phe Cys Gly Pro 180 185 190 Asn Arg Val Asp Tyr Ile Phe Cys Asp Ile Pro Ala Met Leu Arg Leu 195 200 205 Ala Cys Ala Asp Thr Ala Ile Asn Glu Leu Val Thr Phe Ala Asp Ile 210 215 220 Gly Phe Leu Ala Leu Thr Cys Phe Met Leu Ile Leu Thr Ser Tyr Gly 225 230 235 240 Tyr Ile Val Ala Ala Ile Leu Arg Ile Pro Ser Ala Asp Gly Arg Arg 245 250 255 Asn Ala Phe Ser Thr Cys Ala Ala His Leu Thr Val Val Ile Val Tyr 260 265 270 Tyr Val Pro Cys Thr Phe Ile Tyr Leu Arg Pro Cys Ser Gln Glu Pro 275 280 285 Leu Asp Gly Val Val Ala Val Phe Tyr Thr Val Ile Thr Pro Leu Leu 290 295 300 Asn Ser Ile Ile Tyr Thr Leu Cys Asn Lys Glu Met Lys Ala Ala Leu 305 310 315 320 Gln Arg Leu Gly Gly His Lys Glu Val Gln Pro His 325 330 <210> 409 <211> 1128 <212> DNA <213> Homo sapiens <220> <2 21> CDS <222> (1)..(1128) <400> 409 atg tcc aac gcc acc cta ctg aca gcg ttc atc ctc acg ggc ctt ccc 48 Met Ser Asn Ala Thr Leu Leu Thr Ala Phe Ile Leu Thr Gly Leu Pro 1 5 10 15 cat gcc cca ggg ctg gac gcc ccc ctc ttt gga atc ttc ctg gtg gtt 96 His Ala Pro Gly Leu Asp Ala Pro Leu Phe Gly Ile Phe Leu Val Val 20 25 30 tac gtg ctc act gtg ctg ggg aac ctc ctc atc ctg ctg gtg atc agg 144 Tyr Val Leu Thr Val Leu Gly Asn Leu Leu Ile Leu Leu Val Ile Arg 35 40 45 gtg gat tct cac ctc cac acc ccc atg tac tac ttc ctc acc aac ctg 192 Val Asp Ser His Leu His Thr Pro Met Tyr Tyr Phe Leu Thr Asn Leu 50 55 60 tcc ttc att gac atg tgg ttc tcc act gtc acg gtg ccc aaa atg ctg 240 Ser Phe Ile Asp Met Trp Phe Ser Thr Val Thr Val Pro Lys Met Leu 65 70 75 80 atg acc ttg gtg tcc cca agc ggc agg act atc tcc ttc cac agc tgc 288 Met Thr Leu Val Ser Pro Ser Gly Arg Thr Ile Ser Phe His Ser Cys 85 90 95 gtg gct cag ctc tat ttt ttc cac ttc ctg ggg agc acc gag tgt ttc 336 Val Ala Gln Leu Tyr Phe Phe His Phe Leu Gly Ser Thr Glu Cys Phe 100 105 110 ctc tac aca gtc atg tcc tat gat cgc tac ctg gcc atc agt tac ccg 384 Leu Tyr Thr Val Met Ser Tyr Asp Arg Tyr Leu Ala Ile Ser Tyr Pro 115 120 125 ctc agg tac acc aac atg atg act ggg cgc tcg tgt gcc ctc ctg gcc 432 Leu Arg Tyr Thr Asn Met Met Thr Gly Arg Ser Cys Ala Leu Leu Ala 130 135 140 acc ggc act tgg ctc agt ggc tct ctg cac tct gct gtc cag acc ata 480 Thr Gly Thr Trp Leu Ser Gly Ser Leu His Ser Ala Val Gln Thr Ile 145 150 155 160 ttg act ttc cat ttg ccc tac tgt gga ccc aac cag atc cag cac tac 528 Leu Thr Phe His Leu Pro Tyr Cys Gly Pro Asn Gln Ile Gln His Tyr 165 170 175 ttc tgt gac gca ccg ccc atc ctg aaa ctg gcc tgt gca gac acc tca 576 Phe Cys Asp Ala Pro Pro Ile Leu Lys Leu Ala Cys Ala Asp Thr Ser 180 185 190 gcc aac gag atg gtc atc ttt gtg aat att ggg cta gtg gcc tcg ggc 624 Ala Asn Glu Met Val Ile Phe Val Asn Ile Gly Leu Val Ala Ser Gly 195 200 205 tgc ttt gtc ctg ata gtg ctg tcc tat gtg tcc atc gtc tgt tcc atc 672 Cys Phe Val Leu Ile Val Leu Ser Tyr Val Ser Ile Val Cys Ser Ile 210 215 220 ctg cgg atc cgc acc tca gag ggg agg cac aga gcc ttt cag acc tgt 720 Leu Arg Ile Arg Thr Ser Glu Gly Arg His Arg Ala Phe Gln Thr Cys 225 230 235 240 gcc tcc cac tgt atc gtg gtc ctt tgc ttc ttt ggc cct ggt ctt ttc 768 Ala Ser His Cys Ile Val Val Leu Cys Phe Phe Gly Pro Gly Leu Phe 245 250 255 att tac ctg agg cca ggc tcc agg gac gcc ttg cat ggg gtt gtg gcc 816 Ile Tyr Leu Arg Pro Gly Ser Arg Asp Ala Leu His Gly Val Val Ala 260 265 270 gtt ttc tac acc acg ctg act cct ctt ttc aac cct gtt gtg tac acc 864 Val Phe Tyr Thr Thr Leu Thr Pro Leu Phe Asn Pro Val Val Tyr Thr 275 280 285 ctg aga aac aag gag gta aag aaa gct ctg ttg aag ctg aaa aat ggt 912 Leu Arg Asn Lys Glu Val Lys Lys Ala Leu Leu Lys Leu Lys Asn Gly 290 295 300 cag tat tgt can nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 960 Gln Tyr Cys Thr Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 305 310 315 320 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 1008 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 325 330 335 nnn nnn nnn nnn nnn agt gaa gtc tat tgt gtc ctc tgt ggt gtc aag 1056 Xaa Xaa Xaa Xaa Xaa Ser Glu Val Tyr Cys Val Leu Cys Gly Val Lys 340 345 350 tct cac tac act cag ata aca gtg ttt tgg gca ggg ttc tct tta att 1104 Ser His Tyr Thr Gln Ile Thr Val Phe Trp Ala Gly Phe Ser Leu Ile 355 360 365 gtc tct ttc cct ggc cac agc tag 1128 Val Ser Phe Pro Gly His Ser 370 375 <210> 410 <211> 375 <212> PRT <213> Homo sapiens <400> 410 Met Ser Asn Ala Thr Leu Leu Thr Ala Phe Ile Leu Thr Gly Leu Pro 1 5 10 15 His Ala Pro Gly Leu Asp Ala Pro Leu Phe Gly Ile Phe Leu Val Val 20 25 30 Tyr Val Leu Thr Val Leu Gly Asn Leu Leu Ile Leu Leu Val Ile Arg 35 40 45 Val Asp Ser His Leu His Thr Pro Met Tyr Tyr Phe Leu Thr Asn Leu 50 55 60 Ser Phe Ile Asp Met Trp Phe Ser Thr Val Thr Val Pro Lys Met Leu 65 70 75 80 Met Thr Leu Val Ser Pro Ser Gly Arg Thr Ile Ser Phe His Ser Cys 85 90 95 Val Ala Gln Leu Tyr Phe Phe His Phe Leu Gly Ser Thr Glu Cys Phe 100 105 110 Leu Tyr Thr Val Met Ser Tyr Asp Arg Tyr Leu Ala Ile Ser Tyr Pro 115 120 125 Leu Arg Tyr Thr Asn Met Met Thr Gly Arg Ser Cys Ala Leu Leu Ala 130 135 140 Thr Gly Thr Trp Leu Ser Gly Ser Leu His Ser Ala Val Gln Thr Ile 145 150 155 160 Leu Thr Phe His Leu Pro Tyr Cys Gly Pro Asn Gln Ile Gln His Tyr 165 170 175 Phe Cys Asp Ala Pro Pro Ile Leu Lys Leu Ala Cys Ala Asp Thr Ser 180 185 190 Ala Asn Glu Met Val Ile Phe Val Asn Ile Gly Leu Val Ala Ser Gly 195 200 205 Cys Phe Val Leu Ile Val Leu Ser Tyr Val Ser Ile Val Cys Ser Ile 210 215 220 Leu Arg Ile Arg Thr Ser Glu Gly Arg His Arg Ala Phe Gln Thr Cys 225 230 235 240 Ala Ser His Cys Ile Val Val Leu Cys Phe Phe Gly Pro Gly Leu Phe 245 250 255 Ile Tyr Leu Arg Pro Gly Ser Arg Asp Ala Leu His Gly Val Val Ala 260 265 270 Val Phe Tyr Thr Thr Leu Thr Pro Leu Phe Asn Pro Val Val Tyr Thr 275 280 285 Leu Arg Asn Lys Glu Val Lys Lys Ala Leu Leu Lys Leu Lys Asn Gly 290 295 300 Gln Tyr Cys Thr Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 305 310 315 320 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 325 330 335 Xaa Xaa Xaa Xaa Xaa Ser Glu Val Tyr Cys Val Leu Cys Gly Val Lys 340 345 350 Ser His Tyr Thr Gln Ile Thr Val Phe Trp Ala Gly Phe Ser Leu Ile 355 360 365 Val Ser Phe Pro Gly His Ser 370 375 <210> 411 <211> 732 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(732) <400> 411 atg tgg ttc tcc act gtc acg gtg ccc aaa atg ctg atg acc ttg gtg 48 Met Trp Phe Ser Thr Val Thr Val Pro Lys Met Leu Met Thr Leu Val 1 5 10 15 tcc cca agc ggc agg gct atc tcc ttc cac agc tgc gtg gct cag ctc 96 Ser Pro Ser Gly Arg Ala Ile Ser Phe His Ser Cys Val Ala Gln Leu 20 25 30 tat ttt ttc cac ttc ctg ggg agc acc gag tgt ttc ctc tac aca gtc 144 Tyr Phe Phe His Phe Leu Gly Ser Thr Glu Cys Phe Leu Tyr Thr Val 35 40 45 atg tcc tat gat cgc tac ttg gcc atc agt tac ccg ctc agg tac acc 192 Met Ser Tyr Asp Arg Tyr Leu Ala Ile Ser Tyr Pro Leu Arg Tyr Thr 50 55 60 agc atg atg agt ggg agc agg tgt gcc ctc ctg gcc acc ggc act tgg 240 Ser Met Met Ser Gly Ser Arg Cys Ala Leu Leu Ala Thr Gly Thr Trp 65 70 75 80 ctc agt ggc tct ctg cac tct gct gtc cag acc ata ttg act ttc cat 288 Leu Ser Gly Ser Leu His Ser Ala Val Gln Thr Ile Leu Thr Phe His 85 90 95 ttg ccc tac tgt gga ccc aac cag atc cag cac tac ttc tgt gac gca 336 Leu Pro Tyr Cys Gly Pro Asn Gln Ile Gln His Tyr Phe Cys Asp Ala 100 105 110 ccg ccc atc ctg aaa ctg gcc tgt gca gac acc tca gcc aac gtg atg 384 Pro Pro Ile Leu Lys Leu Ala Cys Ala Asp Thr Ser Ala Asn Val Met 115 120 125 gtc atc ttt gtg gac att ggg ata gtg gcc tca ggc tgc ttt gtc ctg 432 Val Ile Phe Val Asp Ile Gly Ile Val Ala Ser Gly Cys Phe Val Leu 130 135 140 ata gtg ctg tcc tat gtg tcc atc gtc tgt tcc atc ctg cgg atc cgc 480 Ile Val Leu Ser Tyr Val Ser Ile Val Cys Ser Ile Leu Arg Ile Arg 145 150 155 160 acc tca gat ggg agg cgc aga gcc ttt cag acc tgt gcc tcc cac tgt 528 Thr Ser Asp Gly Arg Arg Arg Ala Phe Gln Thr Cys Ala Ser His Cys 165 170 175 att gtg gtc ctt tgc ttc ttt gtt ccc tgt gtt gtc att tat ctg agg 576 Ile Val Val Leu Cys Phe Phe Val Pro Cys Val Val Ile Tyr Leu Arg 180 185 190 cca ggc tcc atg gat gcc atg gat gga gtt gtg gcc att ttc tac act 624 Pro Gly Ser Met Asp Ala Met Asp Gly Val Val Ala Ile Phe Tyr Thr 195 200 205 gtg ctg acg ccc ctt ctc aac cct gtt gtg tac acc ctg aga aac aag 672 Val Leu Thr Pro Leu Leu Asn Pro Val Val Tyr Thr Leu Arg Asn Lys 210 215 220 gag gtg aag aaa gct gtg ttg aaa ctt aga gac aaa gta gca cat cct 720 Glu Val Lys Lys Ala Val Leu Lys Leu Arg Asp Lys Val Ala His Pro 225 230 235 240 cag agg aaa taa 732 Gln Arg Lys <210> 412 <211> 243 <212> PRT <213> Homo sapiens <400> 412 Met Trp Phe Ser Thr Val Thr Val Pro Lys Met Leu Met Thr Leu Val 1 5 10 15 Ser Pro Ser Gly Arg Ala Ile Ser Phe His Ser Cys Val Ala Gln Leu 20 25 30 Tyr Phe Phe His Phe Leu Gly Ser Thr Glu Cys Phe Leu Tyr Thr Val 35 40 45 Met Ser Tyr Asp Arg Tyr Leu Ala Ile Ser Tyr Pro Leu Arg Tyr Thr 50 55 60 Ser Met Met Ser Gly Ser Arg Cys Ala Leu Leu Ala Thr Gly Thr Trp 65 70 75 80 Leu Ser Gly Ser Leu His Ser Ala Val Gln Thr Ile Leu Thr Phe His 85 90 95 Leu Pro Tyr Cys Gly Pro Asn Gln Ile Gln His Tyr Phe Cys Asp Ala 100 105 110 Pro Pro Ile Leu Lys Leu Ala Cys Ala Asp Thr Ser Ala Asn Val Met 115 120 125 Val Ile Phe Val Asp Ile Gly Ile Val Ala Ser Gly Cys Phe Val Leu 130 135 140 Ile Val Leu Ser Tyr Val Ser Ile Val Cys Ser Ile Leu Arg Ile Arg 145 150 155 160 Thr Ser Asp Gly Arg Arg Arg Ala Phe Gln Thr Cys Ala Ser His Cys 165 170 175 Ile Val Val Leu Cys Phe Phe Val Pro Cys Val Val Ile Tyr Leu Arg 180 185 190 Pro Gly Ser Met Asp Ala Met Asp Gly Val Val Ala Ile Phe Tyr Thr 195 200 205 Val Leu Thr Pro Leu Leu Asn Pro Val Val Tyr Thr Leu Arg Asn Lys 210 215 220 Glu Val Lys Lys Ala Val Leu Lys Leu Arg Asp Lys Val Ala His Pro 225 230 235 240 Gln Arg Lys <210> 413 <211> 936 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(936) <400> 413 atg tcc aac gcc agc cta ctg aca gcg ttc atc ctc atg ggc ctt ccc 48 Met Ser Asn Ala Ser Leu Leu Thr Ala Phe Ile Leu Met Gly Leu Pro 1 5 10 15 cat gcc cca gcg ctg gac gcc ccc ctc ttt gga gtc ttc ctg gtg gtt 96 His Ala Pro Ala Leu Asp Ala Pro Leu Phe Gly Val Phe Leu Val Val 20 25 30 tac gtg ctc act gtg ctg ggg aac ctc ctc atc ctg ctg gtg atc agg 144 Tyr Val Leu Thr Val Leu Gly Asn Leu Leu Ile Leu Leu Val Ile Arg 35 40 45 gtg gat tct cac ctc cac acc acc atg tac tac ttc ctc acc aac ctg 192 Val Asp Ser His Leu His Thr Thr Met Tyr Tyr Phe Leu Thr Asn Leu 50 55 60 tcg ttc att gac atg tgg ttc tcc act gtc acg gtg ccc aaa ttg ctg 240 Ser Phe Ile Asp Met Trp Phe Ser Thr Val Thr Val Pro Lys Leu Leu 65 70 75 80 atg act ttg gtg ttc cca agt ggc agg gct atc tcc ttc cac agc tgc 288 Met Thr Leu Val Phe Pro Ser Gly Arg Ala Ile Ser Phe His Ser Cys 85 90 95 atg gct cag ctc tat ttc ttt cac ttc cta ggg ggc acc gag tgt ttc 336 Met Ala Gln Leu Tyr Phe Phe His Phe Leu Gly Gly Thr Glu Cys Phe 100 105 110 ctc tac agg gtc atg tcc tgt gat cgc tac ctg gcc atc agt tac ccg 384 Leu Tyr Arg Val Met Ser Cys Asp Arg Tyr Leu Ala Ile Ser Tyr Pro 115 120 125 ctc agg tac acc agc atg atg act ggg cgc tcg tgt act ctt ctg gcc 432 Leu Arg Tyr Thr Ser Met Met Thr Gly Arg Ser Cys Thr Leu Leu Ala 130 135 140 acc agc act tgg ctc agt ggc tct ctg cac tct gct gtc cag gcc ata 480 Thr Ser Thr Trp Leu Ser Gly Ser Leu His Ser Ala Val Gln Ala Ile 145 150 155 160 ttg act ttc cat ttg ccc tac tgt gga ccc aac tgg atc cag cac tat 528 Leu Thr Phe His Leu Pro Tyr Cys Gly Pro Asn Trp Ile Gln His Tyr 165 170 175 ttg tgt gat gca ccg ccc atc ctg aaa ctg gcc tgt gca gac acc tca 576 Leu Cys Asp Ala Pro Pro Ile Leu Lys Leu Ala Cys Ala Asp Thr Ser 180 185 190 gcc ata gag act gtc att ttt gtg act gtt gga ata gtg gcc tcg ggc 624 Ala Ile Glu Thr Val Ile Phe Val Thr Val Gly Ile Val Ala Ser Gly 195 200 205 tgc ttt gtc ctg ata gtg ctg tcc tat gtg tcc atc gtc tgt tcc atc 672 Cys Phe Val Leu Ile Val Leu Ser Tyr Val Ser Ile Val Cys Ser Ile 210 215 220 ctg cgg atc cgc acc tca gag ggg aag cac aga gcc ttt cag acc tgt 720 Leu Arg Ile Arg Thr Ser Glu Gly Lys His Arg Ala Phe Gln Thr Cys 225 230 235 240 gcc tcc cac tgt atc gtg gtc ctt tgc ttc ttt ggc cct ggt ctt ttc 768 Ala Ser His Cys Ile Val Val Leu Cys Phe Phe Gly Pro Gly Leu Phe 245 250 255 att tac ctg agg cca ggc tcc agg aaa gct gtg gat gga gtt gtg gcc 816 Ile Tyr Leu Arg Pro Gly Ser Arg Lys Ala Val Asp Gly Val Val Ala 260 265 270 gtt ttc tac act gtg ctg acg ccc ctt ctc aac cct gtt gtg tac acc 864 Val Phe Tyr Thr Val Leu Thr Pro Leu Leu Asn Pro Val Val Tyr Thr 275 280 285 ctg agg aac aag gag gtg aag aaa gct ctg ttg aag ctg aaa gac aaa 912 Leu Arg Asn Lys Glu Val Lys Lys Ala Leu Leu Lys Leu Lys Asp Lys 290 295 300 gta gca cat tct cag agc aaa tag 936 Val Ala His Ser Gln Ser Lys 305 310 <210> 414 <211> 311 <212> PRT <213> Homo sapiens <400> 414 Met Ser Asn Ala Ser Leu Leu Thr Ala Phe Ile Leu Met Gly Leu Pro 1 5 10 15 His Ala Pro Ala Leu Asp Ala Pro Leu Phe Gly Val Phe Leu Val Val 20 25 30 Tyr Val Leu Thr Val Leu Gly Asn Leu Leu Ile Leu Leu Val Ile Arg 35 40 45 Val Asp Ser His Leu His Thr Thr Met Tyr Tyr Phe Leu Thr Asn Leu 50 55 60 Ser Phe Ile Asp Met Trp Phe Ser Thr Val Thr Val Pro Lys Leu Leu 65 70 75 80 Met Thr Leu Val Phe Pro Ser Gly Arg Ala Ile Ser Phe His Ser Cys 85 90 95 Met Ala Gln Leu Tyr Phe Phe His Phe Leu Gly Gly Thr Glu Cys Phe 100 105 110 Leu Tyr Arg Val Met Ser Cys Asp Arg Tyr Leu Ala Ile Ser Tyr Pro 115 120 125 Leu Arg Tyr Thr Ser Met Met Thr Gly Arg Ser Cys Thr Leu Leu Ala 130 135 140 Thr Ser Thr Trp Leu Ser Gly Ser Leu His Ser Ala Val Gln Ala Ile 145 150 155 160 Leu Thr Phe His Leu Pro Tyr Cys Gly Pro Asn Trp Ile Gln His Tyr 165 170 175 Leu Cys Asp Ala Pro Pro Ile Leu Lys Leu Ala Cys Ala Asp Thr Ser 180 185 190 Ala Ile Glu Thr Val Ile Phe Val Thr Val Gly Ile Val Ala Ser Gly 195 200 205 Cys Phe Val Leu Ile Val Leu Ser Tyr Val Ser Ile Val Cys Ser Ile 210 215 220 Leu Arg Ile Arg Thr Ser Glu Gly Lys His Arg Ala Phe Gln Thr Cys 225 230 235 240 Ala Ser His Cys Ile Val Val Leu Cys Phe Phe Gly Pro Gly Leu Phe 245 250 255 Ile Tyr Leu Arg Pro Gly Ser Arg Lys Ala Val Asp Gly Val Val Ala 260 265 270 Val Phe Tyr Thr Val Leu Thr Pro Leu Leu Asn Pro Val Val Tyr Thr 275 280 285 Leu Arg Asn Lys Glu Val Lys Lys Ala Leu Leu Lys Leu Lys Asp Lys 290 295 300 Val Ala His Ser Gln Ser Lys 305 310 <210> 415 <211> 663 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(663) <400> 415 atg ggc cag cta ttt aca gac cac ttg ttt ggt gga act gag atc ttc 48 Met Gly Gln Leu Phe Thr Asp His Leu Phe Gly Gly Thr Glu Ile Phe 1 5 10 15 ctt ctg gtg gtg atg gcc tat gat cgc tac gtg gcc atc tgt aag cca 96 Leu Leu Val Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro 20 25 30 ctg cac tat tta acc atc atg aat cga cag gtt tcc atc ctt ctg ttg 144 Leu His Tyr Leu Thr Ile Met Asn Arg Gln Val Ser Ile Leu Leu Leu 35 40 45 gtg gtg gcc atg act gga ggt ttc ctt cat tct gtg ttt caa att gct 192 Val Val Ala Met Thr Gly Gly Phe Leu His Ser Val Phe Gln Ile Ala 50 55 60 gtt ctg tac agt ctc cct ttc tgt ggc ccc aat gtc att gac cac ttt 240 Val Leu Tyr Ser Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Phe 65 70 75 80 ttc tgt gac atg tac cca tta ttg gaa ctg gcg tgc act gac acc tac 288 Phe Cys Asp Met Tyr Pro Leu Leu Glu Leu Ala Cys Thr Asp Thr Tyr 85 90 95 tct ata ggc ctc act gta gtt ttc agt ggt gga gca atg tgt atg gtc 336 Ser Ile Gly Leu Thr Val Val Phe Ser Gly Gly Ala Met Cys Met Val 100 105 110 atc ttc gcc ctt cta cta atc tcc tat gga gtc agc cta aac tcc ctt 384 I le Phe Ala Leu Leu Leu Ile Ser Tyr Gly Val Ser Leu Asn Ser Leu 115 120 125 aaa act tat agt cag gaa ggg agg cgt aaa gcc ctg tct acc tgc agc 432 Lys Thr Tyr Ser Gln Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Ser 130 135 140 tcg cac atc acc gtg gtt gtc ctc ttt ttt gtt ccc tgt att ttc atg 480 Ser His Ile Thr Val Val Val Leu Phe Phe Val Pro Cys Ile Phe Met 145 150 155 160 tat gtt aga cct gtc tca aac ttc cct att gat aaa ttc gtt act gtg 528 Tyr Val Arg Pro Val Ser Asn Phe Pro Ile Asp Lys Phe Val Thr Val 165 170 175 ttt tat aca gtt atc aca ccc atg ctg aat cct ttt tta tac acg ttg 576 Phe Tyr Thr Val Ile Thr Pro Met Leu Asn Pro Phe Leu Tyr Thr Leu 180 185 190 aga aat tca gag atg ata aat gct ata aaa cac ctg ttg tgt aag aag 624 Arg Asn Ser Glu Met Ile Asn Ala Ile Lys His Leu Leu Cys Lys Lys 195 200 205 cta act ata gtt aga ata aga gtg tcc ctc ctc atg tag 663 Leu Thr Ile Val Arg Ile Arg Val Ser Leu Leu Met 210 215 220 <210> 416 <211> 220 <212> PRT <213> Homo sapiens <400> 416 Met Gly Gln Leu Phe Thr Asp His Leu Phe Gly Gly Thr Glu Ile Phe 1 5 10 15 Leu Leu Val Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro 20 25 30 Leu His Tyr Leu Thr Ile Met Asn Arg Gln Val Ser Ile Leu Leu Leu 35 40 45 Val Val Ala Met Thr Gly Gly Phe Leu His Ser Val Phe Gln Ile Ala 50 55 60 Val Leu Tyr Ser Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Phe 65 70 75 80 Phe Cys Asp Met Tyr Pro Leu Leu Glu Leu Ala Cys Thr Asp Thr Tyr 85 90 95 Ser Ile Gly Leu Thr Val Val Phe Ser Gly Gly Ala Met Cys Met Val 100 105 110 Ile Phe Ala Leu Leu Leu Ile Ser Tyr Gly Val Ser Leu Asn Ser Leu 115 120 125 Lys Thr Tyr Ser Gln Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Ser 130 135 140 Ser His Ile Thr Val Val Val Leu Phe Phe Val Pro Cys Ile Phe Met 145 150 155 160 Tyr Val Arg Pro Val Ser Asn Phe Pro Ile Asp Lys Phe Val Thr Val 165 170 175 Phe Tyr Thr Val Ile Thr Pro Met Leu Asn Pro Phe Leu Tyr Thr Leu 180 185 190 Arg Asn Ser Glu Met Ile Asn Ala Ile Lys His Leu Leu Cys Lys Lys 195 200 205 Leu Thr Ile Val Arg Ile Arg Val Ser Leu Leu Met 210 215 220 <210> 417 <211> 1548 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1548) <400> 417 atg cag caa aat aac agt gtg cct gaa ttc ata ctg tta gga tta aca 48 Met Gln Gln Asn Asn Ser Val Pro Glu Phe Ile Leu Leu Gly Leu Thr 1 5 10 15 cag gat ccc ttg agg cag aaa ata gtg ttt gta atc ttc tta att ttc 96 Gln Asp Pro Leu Arg Gln Lys Ile Val Phe Val Ile Phe Leu Ile Phe 20 25 30 tat atg gga act gtg gtg ggg aat atg ctc att att gtg acc atc aag 144 Tyr Met Gly Thr Val Val Gly Asn Met Leu Ile Ile Val Thr Ile Lys 35 40 45 tcc agc cgg aca cta gga agc ccc atg tac ttc ttt cta ttt tat ttg 192 Ser Ser Arg Thr Leu Gly Ser Pro Met Tyr Phe Phe Leu Phe Tyr Leu 50 55 60 tcc ttt gca gat tct tgc ttt tca act tcc aca gcc cct aga tta att 240 Ser Phe Ala Asp Ser Cys Phe Ser Thr Ser Thr Ala Pro Arg Leu Ile 65 70 75 80 gtg gat gct ctc tct gaa aag aaa att ata acc tac aat gag tgc atg 288 Val Asp Ala Leu Ser Glu Lys Lys Ile Ile Thr Tyr Asn Glu Cys Met 85 90 95 aca caa gtc ttt gca cta cat tta ttt ggc tgc atg gag atc ttt gtc 336 Thr Gln Val Phe Ala Leu His Leu Phe Gly Cys Met Glu Ile Phe Val 100 105 110 ctc att ctc atg gct gtt gat cgc tat gtg gcc atc tgt aag ccc ttg 384 Leu Ile Leu Met Ala Val Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 cgt tac cca acc atc atg agc cag cag gtc tgc atc atc ctg att gtt 432 Arg Tyr Pro Thr Ile Met Ser Gln Gln Val Cys Ile Ile Leu Ile Val 130 135 140 ctt gcc tgg ata ggg tct tta ata cac tct aca gct cag att atc ctg 480 Leu Ala Trp Ile Gly Ser Leu Ile His Ser Thr Ala Gln Ile Ile Leu 145 150 155 160 gcc tta aga ttg cct ttc tgt gga ccc tat ttg att gat cat tat tgc 528 Ala Leu Arg Leu Pro Phe Cys Gly Pro Tyr Leu Ile Asp His Tyr Cys 165 170 175 tgt gat ttg cag ccc ttg ttg aaa ctt gcc tgc atg gac act tac atg 576 Cys Asp Leu Gln Pro Leu Leu Lys Leu Ala Cys Met Asp Thr Tyr Met 180 185 190 atc aac ctg ctg ttg gtg tct aac agt ggg gca att tgc tca agt agt 624 Ile Asn Leu Leu Leu Val Ser Asn Ser Gly Ala Ile Cys Ser Ser Ser 195 200 205 ttc atg att ttg ata att tca tat att gtc atc ttg cat tca ctg aga 672 Phe Met Ile Leu Ile Ile Ser Tyr Ile Val Ile Leu His Ser Leu Arg 210 215 220 aac cac agt gcc aaa ggg aag aaa aag gct ctc tcc gct tgc acg tct 720 Asn His Ser Ala Lys Gly Lys Lys Lys Ala Leu Ser Ala Cys Thr Ser 225 230 235 240 cac ata att gta gtc atc tta ttc ttt ggc cca tgt ata ttc ata tat 768 His Ile Ile Val Val Ile Leu Phe Phe Gly Pro Cys Ile Phe Ile Tyr 245 250 255 aca cgc ccc ccg acc act ttc ccc atg gac aag atg gtg gca gta ttt 816 Thr Arg Pro Pro Thr Thr Phe Pro Met Asp Lys Met Val Ala Val Phe 260 265 270 tat act att gga aca ccc ttt ctc aat cca ctc atc tac aca tct gag 864 Tyr Thr Ile Gly Thr Pro Phe Leu Asn Pro Leu Ile Tyr Thr Ser Glu 275 280 285 gaa tgc aga agt gaa aaa tgc cat gag aaa gnn nnn nnn nnn nnn nnn 912 Glu Cys Arg Ser Glu Lys Cys His Glu Lys Xaa Xaa Xaa Xaa Xaa Xaa 290 295 300 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 960 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 305 310 315 320 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nna aag aag gga gga 1008 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Lys Gly Gly 325 330 335 gag aga gag aca aag agg gag gga ggg aaa gga aga aag aaa gac aga 1056 Glu Arg Glu Thr Lys Arg Glu Gly Gly Lys Gly Arg Lys Lys Asp Arg 340 345 350 aag aga gag aag aaa gag aga gag aga aag aaa gaa gaa aga aag aga 1104 Lys Arg Glu Lys Lys Glu Arg Glu Arg Lys Lys Glu Glu Arg Lys Arg 355 360 365 gaa aga aaa aga aag aaa gaa aga aaa aat aaa aag aaa aga gag gaa 1152 Glu Arg Lys Arg Lys Lys Glu Arg Lys Asn Lys Lys Lys Arg Glu Glu 370 375 380 gaa ggg aaa gaa caa gag aaa gaa aga aga aag aaa ggg ata aca ttt 1200 Glu Gly Lys Glu Gln Glu Lys Glu Arg Arg Lys Lys Gly Ile Thr Phe 385 390 395 400 tat cat gta gat tac tat agt act aaa tcc att att aga cat tta aat 1248 Tyr His Val Asp Tyr Tyr Ser Thr Lys Ser Ile Ile Arg His Leu Asn 405 410 415 tgt ttc caa gtt gaa act aat aaa aat gct gtg gtt aaa atc tta aaa 1296 Cys Phe Gln Val Glu Thr Asn Lys Asn Ala Val Val Lys Ile Leu Lys 420 425 430 aaa aaa aga aag aaa gaa aga aga aaa aag aaa gac aag aaa gaa aga 1344 Lys Lys Arg Lys Lys Glu Arg Arg Lys Lys Lys Asp Lys Lys Glu Arg 435 440 445 aga aag aaa gag aaa gaa gaa aga aaa gaa aga aaa aga aga aag aaa 1392 Arg Lys Lys Glu Lys Glu Glu Arg Lys Glu Arg Lys Arg Arg Lys Lys 450 455 460 gaa aga aag gaa aag aaa aga aag gaa gaa atg aag gaa gaa aag aaa 1440 Glu Arg Lys Glu Lys Lys Arg Lys Glu Glu Met Lys Glu Glu Lys Lys 465 470 475 480 gaa aga aag aaa aaa gaa aga aag aaa gaa aga aag aga aag aaa gaa 1488 Glu Arg Lys Lys Lys Glu Arg Lys Lys Glu Arg Lys Arg Lys Lys Glu 485 490 495 gga aag aga aag aaa gaa aag aaa gaa aga aag aga gaa agg gag gga 1536 Gly Lys Arg Lys Lys Glu Lys Lys Glu Arg Lys Arg Glu Arg Glu Gly 500 505 510 agg aac aaa tga 1548 Arg Asn Lys 515 <210> 418 <211> 515 <212> PRT <213> Homo sapiens <400> 418 Met Gln Gln Asn Asn Ser Val Pro Glu Phe Ile Leu Leu Gly Leu Thr 1 5 10 15 Gln Asp Pro Leu Arg Gln Lys Ile Val Phe Val Ile Phe Leu Ile Phe 20 25 30 Tyr Met Gly Thr Val Val Gly Asn Met Leu Ile Ile Val Thr Ile Lys 35 40 45 Ser Ser Arg Thr Leu Gly Ser Pro Met Tyr Phe Phe Leu Phe Tyr Leu 50 55 60 Ser Phe Ala Asp Ser Cys Phe Ser Thr Ser Thr Ala Pro Arg Leu Ile 65 70 75 80 Val Asp Ala Leu Ser Glu Lys Lys Ile Ile Thr Tyr Asn Glu Cys Met 85 90 95 Thr Gln Val Phe Ala Leu His Leu Phe Gly Cys Met Glu Ile Phe Val 100 105 110 Leu Ile Leu Met Ala Val Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 Arg Tyr Pro Thr Ile Met Ser Gln Gln Val Cys Ile Ile Leu Ile Val 130 135 140 Leu Ala Trp Ile Gly Ser Leu Ile His Ser Thr Ala Gln Ile Ile Leu 145 150 155 160 Ala Leu Arg Leu Pro Phe Cys Gly Pro Tyr Leu Ile Asp His Tyr Cys 165 170 175 Cys Asp Leu Gln Pro Leu Leu Lys Leu Ala Cys Met Asp Thr Tyr Met 180 185 190 Ile Asn Leu Leu Leu Val Ser Asn Ser Gly Ala Ile Cys Ser Ser Ser 195 200 205 Phe Met Ile Leu Ile Ile Ser Tyr Ile Val Ile Leu His Ser Leu Arg 210 215 220 Asn His Ser Ala Lys Gly Lys Lys Lys Ala Leu Ser Ala Cys Thr Ser 225 230 235 240 His Ile Ile Val Val Ile Leu Phe Phe Gly Pro Cys Ile Phe Ile Tyr 245 250 255 Thr Arg Pro Pro Thr Thr Phe Pro Met Asp Lys Met Val Ala Val Phe 260 265 270 Tyr Thr Ile Gly Thr Pro Phe Leu Asn Pro Leu Ile Tyr Thr Ser Glu 275 280 285 Glu Cys Arg Ser Glu Lys Cys His Glu Lys Xaa Xaa Xaa Xaa Xaa Xaa 290 295 300 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 305 310 315 320 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Lys Gly Gly 325 330 335 Glu Arg Glu Thr Lys Arg Glu Gly Gly Lys Gly Arg Lys Lys Asp Arg 340 345 350 Lys Arg Glu Lys Lys Glu Arg Glu Arg Lys Lys Glu Glu Arg Lys Arg 355 360 365 Glu Arg Lys Arg Lys Lys Glu Arg Lys Asn Lys Lys Lys Arg Glu Glu 370 375 380 Glu Gly Lys Glu Gln Glu Lys Glu Arg Arg Lys Lys Gly Ile Thr Phe 385 390 395 400 Tyr His Val Asp Tyr Tyr Ser Thr Lys Ser Ile Ile Arg His Leu Asn 405 410 415 Cys Phe Gln Val Glu Thr Asn Lys Asn Ala Val Val Lys Ile Leu Lys 420 425 430 Lys Lys Arg Lys Lys Glu Arg Arg Lys Lys Lys Asp Lys Lys Glu Arg 435 440 445 Arg Lys Lys Glu Lys Glu Glu Arg Lys Glu Arg Lys Arg Arg Lys Lys 450 455 460 Glu Arg Lys Glu Lys Lys Arg Lys Glu Glu Met Lys Glu Glu Lys Lys 465 470 475 480 Glu Arg Lys Lys Lys Glu Arg Lys Lys Glu Arg Lys Arg Lys Lys Glu 485 490 495 Gly Lys Arg Lys Lys Glu Lys Lys Glu Arg Lys Arg Glu Arg Glu Gly 500 505 510 Arg Asn Lys 515 <210> 419 <211> 960 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(960) <400> 419 atg aca cct gga gaa cta gcc ctt gcc agt ggc aac cac acc cca gtc 48 Met Thr Pro Gly Glu Leu Ala Leu Ala Ser Gly Asn His Thr Pro Val 1 5 10 15 acc aag ttc atc ttg cag gga ttc tcc aat tat cca gac ctc cag gag 96 Thr Lys Phe Ile Leu Gln Gly Phe Ser Asn Tyr Pro Asp Leu Gln Glu 20 25 30 ctt ctc ttc gga gcc atc ctg ctc atc tat gcc ata aca gtg gtg ggc 144 Leu Leu Phe Gly Ala Ile Leu Leu Ile Tyr Ala Ile Thr Val Val Gly 35 40 45 aac ttg gga atg atg gca ctc atc ttc aca gac tcc cat ctc caa agc 192 Asn Leu Gly Met Met Ala Leu Ile Phe Thr Asp Ser His Leu Gln Ser 50 55 60 cca atg tat ttc ttc ctc aat gtc ctc tcg ttt ctt gat att tgt tac 240 Pro Met Tyr Phe Phe Leu Asn Val Leu Ser Phe Leu Asp Ile Cys Tyr 65 70 75 80 tct tct gtg gtc aca cct aag ctc ttg gtc aac ttc ctg gtc tct gac 288 Ser Ser Val Val Thr Pro Lys Leu Leu Val Asn Phe Leu Val Ser Asp 85 90 95 aag tcc atc tct ttt gag ggc tgt gtg gtc cag ctc gcc ttc ttt gta 336 Lys Ser Ile Ser Phe Glu Gly Cys Val Val Gln Leu Ala Phe Phe Val 100 105 110 gtg cat gtg aca gct gag agc ttc ctg ctg gcc tcc atg gcc tat gac 384 Val His Val Thr Ala Glu Ser Phe Leu Leu Ala Ser Met Ala Tyr Asp 115 120 125 cgc ttc cta gcc atc tgt caa ccc ctc cat tat ggt tct atc atg acc 432 Arg Phe Leu Ala Ile Cys Gln Pro Leu His Tyr Gly Ser Ile Met Thr 130 135 140 agg ggg acc tgt ctc cag ctg gta gct gtg tcc tat gca ttt ggt gga 480 Arg Gly Thr Cys Leu Gln Leu Val Ala Val Ser Tyr Ala Phe Gly Gly 145 150 155 160 gcc aac tcc gct atc cag act gga aat gtc ttt gcc ctg cct ttc tgt 528 Ala Asn Ser Ala Ile Gln Thr Gly Asn Val Phe Ala Leu Pro Phe Cys 165 170 175 ggg ccc aac cag cta aca cac tac tac tgt gac ata cca ccc ctt ctc 576 Gly Pro Asn Gln Leu Thr His Tyr Tyr Cys Asp Ile Pro Pro Leu Leu 180 185 190 cac ctg gct tgt gcc aac aca gcc aca gca aga gtg gtc ctc tat gtc 624 His Leu Ala Cys Ala Asn Thr Ala Thr Ala Arg Val Val Leu Tyr Val 195 200 205 ttt tct gct ctg gtc acc ctt ctg cct gct gca gtc att ctc acc tcc 672 Phe Ser Ala Leu Val Thr Leu Leu Pro Ala Ala Val Ile Leu Thr Ser 210 215 220 tac tgc ttg gtc ttg gtg gcc att ggg agg atg cgc tca gta gca ggg 720 Tyr Cys Leu Val Leu Val Ala Ile Gly Arg Met Arg Ser Val Ala Gly 225 230 235 240 agg gag aag gac ctc tcc act tgt gcc tcc cac ttt ctg gcc att gcc 768 Arg Glu Lys Asp Leu Ser Thr Cys Ala Ser His Phe Leu Ala Ile Ala 245 250 255 att ttc tat ggc act gtg gtt ttc acc tat gtt cag ccc cat gga tct 816 Ile Phe Tyr Gly Thr Val Val Phe Thr Tyr Val Gln Pro His Gly Ser 260 265 270 act aac aat acc aat ggc caa gta gtg tcc gtc ttc tac acc atc ata 864 Thr Asn Asn Thr Asn Gly Gln Val Val Ser Val Phe Tyr Thr Ile Ile 275 280 285 att ccc atg ctc aat ccc ttc atc tat agc ctc cgc aac aag gag gtg 912 Ile Pro Met Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn Lys Glu Val 290 295 300 aag ggc gct ctg cag agg aag ctt cag gtc aac atc ttt ccc ggc tga 960 Lys Gly Ala Leu Gln Arg Lys Leu Gln Val Asn Ile Phe Pro Gly 305 310 315 320 <210> 420 <211> 319 <212> PRT <213> Homo sapiens <400> 420 Met Thr Pro Gly Glu Leu Ala Leu Ala Ser Gly Asn His Thr Pro Val 1 5 10 15 Thr Lys Phe Ile Leu Gln Gly Phe Ser Asn Tyr Pro Asp Leu Gln Glu 20 25 30 Leu Leu Phe Gly Ala Ile Leu Leu Ile Tyr Ala Ile Thr Val Val Gly 35 40 45 Asn Leu Gly Met Met Ala Leu Ile Phe Thr Asp Ser His Leu Gln Ser 50 55 60 Pro Met Tyr Phe Phe Leu Asn Val Leu Ser Phe Leu Asp Ile Cys Tyr 65 70 75 80 Ser Ser Val Val Thr Pro Lys Leu Leu Val Asn Phe Leu Val Ser Asp 85 90 95 Lys Ser Ile Ser Phe Glu Gly Cys Val Val Gln Leu Ala Phe Phe Val 100 105 110 Val His Val Thr Ala Glu Ser Phe Leu Leu Ala Ser Met Ala Tyr Asp 115 120 125 Arg Phe Leu Ala Ile Cys Gln Pro Leu His Tyr Gly Ser Ile Met Thr 130 135 140 Arg Gly Thr Cys Leu Gln Leu Val Ala Val Ser Tyr Ala Phe Gly Gly 145 150 155 160 Ala Asn Ser Ala Ile Gln Thr Gly Asn Val Phe Ala Leu Pro Phe Cys 165 170 175 Gly Pro Asn Gln Leu Thr His Tyr Tyr Cys Asp Ile Pro Pro Leu Leu 180 185 190 His Leu Ala Cys Ala Asn Thr Ala Thr Ala Arg Val Val Leu Tyr Val 195 200 205 Phe Ser Ala Leu Val Thr Leu Leu Pro Ala Ala Val Ile Leu Thr Ser 210 215 220 Tyr Cys Leu Val Leu Val Ala Ile Gly Arg Met Arg Ser Val Ala Gly 225 230 235 240 Arg Glu Lys Asp Leu Ser Thr Cys Ala Ser His Phe Leu Ala Ile Ala 245 250 255 Ile Phe Tyr Gly Thr Val Val Phe Thr Tyr Val Gln Pro His Gly Ser 260 265 270 Thr Asn Asn Thr Asn Gly Gln Val Val Ser Val Phe Tyr Thr Ile Ile 275 280 285 Ile Pro Met Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn Lys Glu Val 290 295 300 Lys Gly Ala Leu Gln Arg Lys Leu Gln Val Asn Ile Phe Pro Gly 305 310 315 <210> 421 <211> 936 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(936) <400> 421 atg aga aga aac tgc acg ttg gtg act gag ttc att ctc ctg gga ctg 48 Met Arg Arg Asn Cys Thr Leu Val Thr Glu Phe Ile Leu Leu Gly Leu 1 5 10 15 acc agt cgc cgg gaa tta caa att ctc ctc ttc acg ctg ttt ctg gcc 96 Thr Ser Arg Arg Glu Leu Gln Ile Leu Leu Phe Thr Leu Phe Leu Ala 20 25 30 att tac atg gtc acg gtg gca ggg aac ctt ggc atg att gtc ctc atc 144 Ile Tyr Met Val Thr Val Ala Gly Asn Leu Gly Met Ile Val Leu Ile 35 40 45 cag gcc aac gcc tgg ctc cac atg ccc atg tac ttt ttc ctg agc cac 192 Gln Ala Asn Ala Trp Leu His Met Pro Met Tyr Phe Phe Leu Ser His 50 55 60 tta tcc ttc gtg gat ctg tgc ttc tct tcc aat gtg act cca aag atg 240 Leu Ser Phe Val Asp Leu Cys Phe Ser Ser Asn Val Thr Pro Lys Met 65 70 75 80 ctg gag att ttc ctt tca gag aag aaa agc att tcc tat cct gcc tgt 288 Leu Glu Ile Phe Leu Ser Glu Lys Lys Ser Ile Ser Tyr Pro Ala Cys 85 90 95 ctt gtg cag tgt tac ctt ttt atc gcc ttg gtc cat gtt gag atc tac 336 Leu Val Gln Cys Tyr Leu Phe Ile Ala Leu Val His Val Glu Ile Tyr 100 105 110 atc ctg gct gtg atg gcc ttt gac cgg tac atg gcc atc tgc aac cct 384 Ile Leu Ala Val Met Ala Phe Asp Arg Tyr Met Ala Ile Cys Asn Pro 115 120 125 ctg ctt tat ggc agc aga atg tcc aag agt gtg tgc tcc ttc ctc atc 432 Leu Leu Tyr Gly Ser Arg Met Ser Lys Ser Val Cys Ser Phe Leu Ile 130 135 140 acg gtg cct tat gtg tat gga gcg ctc act ggc ctg atg gag acc atg 480 Thr Val Pro Tyr Val Tyr Gly Ala Leu Thr Gly Leu Met Glu Thr Met 145 150 155 160 tgg acc tac aac cta gcc ttc tgt ggc ccc aat gaa att aat cac ttc 528 Trp Thr Tyr Asn Leu Ala Phe Cys Gly Pro Asn Glu Ile Asn His Phe 165 170 175 tac tgt gcg gac cca cca ctg att aag ctg gct tgt tct gac acc tac 576 Tyr Cys Ala Asp Pro Pro Leu Ile Lys Leu Ala Cys Ser Asp Thr Tyr 180 185 190 aac aag gag ttg tca atg ttt att gtg gct ggc tgg aac ctt tct ttt 624 Asn Lys Glu Leu Ser Met Phe Ile Val Ala Gly Trp Asn Leu Ser Phe 195 200 205 tct ctc ttc atc ata tgt att tcc tac ctt tac att ttc cct gct att 672 Ser Leu Phe Ile Ile Cys Ile Ser Tyr Leu Tyr Ile Phe Pro Ala Ile 210 215 220 tta aag att cgc tct aca gag ggc agg caa aaa gct ttt tct acc tgt 720 Leu Lys Ile Arg Ser Thr Glu Gly Arg Gln Lys Ala Phe Ser Thr Cys 225 230 235 240 ggc tcc cat ctg aca gct gtc act ata ttc tat gca acc ctt ttc ttc 768 Gly Ser His Leu Thr Ala Val Thr Ile Phe Tyr Ala Thr Leu Phe Phe 245 250 255 atg tat ctc aga ccc ccc tca aag gaa tct gtt gaa cag ggt aaa atg 816 Met Tyr Leu Arg Pro Pro Ser Lys Glu Ser Val Glu Gln Gly Lys Met 260 265 270 gta gct gta ttt tat acc aca gta atc cct atg ctg aac ctt ata att 864 Val Ala Val Phe Tyr Thr Thr Val Ile Pro Met Leu Asn Leu Ile Ile 275 280 285 tat agc ctt aga aat aaa aat gta aaa gaa gca tta atc aaa gag ctg 912 Tyr Ser Leu Arg Asn Lys Asn Val Lys Glu Ala Leu Ile Lys Glu Leu 290 295 300 tca atg aag ata tac ttt tct taa 936 Ser Met Lys Ile Tyr Phe Ser 305 310 <210> 422 <211> 311 <212> PRT <213> Homo sapiens <400> 422 Met Arg Arg Asn Cys Thr Leu Val Thr Glu Phe Ile Leu Leu Gly Leu 1 5 10 15 Thr Ser Arg Arg Glu Leu Gln Ile Leu Leu Phe Thr Leu Phe Leu Ala 20 25 30 Ile Tyr Met Val Thr Val Ala Gly Asn Leu Gly Met Ile Val Leu Ile 35 40 45 Gln Ala Asn Ala Trp Leu His Met Pro Met Tyr Phe Phe Leu Ser His 50 55 60 Leu Ser Phe Val Asp Leu Cys Phe Ser Ser Asn Val Thr Pro Lys Met 65 70 75 80 Leu Glu Ile Phe Leu Ser Glu Lys Lys Ser Ile Ser Tyr Pro Ala Cys 85 90 95 Le u Val Gln Cys Tyr Leu Phe Ile Ala Leu Val His Val Glu Ile Tyr 100 105 110 Ile Leu Ala Val Met Ala Phe Asp Arg Tyr Met Ala Ile Cys Asn Pro 115 120 125 Leu Leu Tyr Gly Ser Arg Met Ser Lys Ser Val Cys Ser Phe Leu Ile 130 135 140 Thr Val Pro Tyr Val Tyr Gly Ala Leu Thr Gly Leu Met Glu Thr Met 145 150 155 160 Trp Thr Tyr Asn Leu Ala Phe Cys Gly Pro Asn Glu Ile Asn His Phe 165 170 175 Tyr Cys Ala Asp Pro Pro Leu Ile Lys Leu Ala Cys Ser Asp Thr Tyr 180 185 190 Asn Lys Glu Leu Ser Met Phe Ile Val Ala Gly Trp Asn Leu Ser Phe 195 200 205 Ser Leu Phe Ile Ile Cys Ile Ser Tyr Leu Tyr Ile Phe Pro Ala Ile 210 215 220 Leu Lys Ile Arg Ser Thr Glu Gly Arg Gln Lys Ala Phe Ser Thr Cys 225 230 235 240 Gly Ser His Leu Thr Ala Val Thr Ile Phe Tyr Ala Thr Leu Phe Phe 245 250 255 Met Tyr Leu Arg Pro Pro Ser Lys Glu Ser Val Glu Gln Gly Lys Met 260 265 270 Val Ala Val Phe Tyr Thr Thr Val Ile Pro Met Leu Asn Leu Ile Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Asn Val Lys Glu Ala Leu Ile Lys Glu Leu 290 295 300 Ser Met Lys Ile Tyr Phe Ser 305 310 <210> 423 <211> 924 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(924) <400> 423 atg ctc aat ttc acc gat gtg aca gag ttc att ctt ttg ggg cta acg 48 Met Leu Asn Phe Thr Asp Val Thr Glu Phe Ile Leu Leu Gly Leu Thr 1 5 10 15 agc cgt cga gaa tgg caa gtt ctc ttc ttc atc atc ttt ctt gtg gtc 96 Ser Arg Arg Glu Trp Gln Val Leu Phe Phe Ile Ile Phe Leu Val Val 20 25 30 tac atc atc acc atg gtg ggc aat atc ggc atg atg gtg tta atc aag 144 Tyr Ile Ile Thr Met Val Gly Asn Ile Gly Met Met Val Leu Ile Lys 35 40 45 gtc agt cct cag ctt aac aac ccc atg tac ttt ttc ctc agt cac ttg 192 Val Ser Pro Gln Leu Asn Asn Pro Met Tyr Phe Phe Leu Ser His Leu 50 55 60 tca ttt gtt gat gtg tgg ttt tct tcc aat gtc acc cct aaa atg ttg 240 Ser Phe Val Asp Val Trp Phe Ser Ser Asn Val Thr Pro Lys Met Leu 65 70 75 80 gaa aac ctg tta tca gat aaa aaa aca att act tat gct ggt tgt tta 288 Glu Asn Leu Leu Ser Asp Lys Lys Thr Ile Thr Tyr Ala Gly Cys Leu 85 90 95 gta cag tgt ttc ttc ttc att gct ctt gtc cat gtg gaa att ttt att 336 Val Gln Cys Phe Phe Phe Ile Ala Leu Val His Val Glu Ile Phe Ile 100 105 110 ctt gct gcg atg gcc ttt gat aga tac atg gca att ggg aat cct ctg 384 Leu Ala Ala Met Ala Phe Asp Arg Tyr Met Ala Ile Gly Asn Pro Leu 115 120 125 ctt tat ggc agt aaa atg tca agg gtt gtc tgt att cga ctg att act 432 Leu Tyr Gly Ser Lys Met Ser Arg Val Val Cys Ile Arg Leu Ile Thr 130 135 140 ttc cct tac att tat ggt ttt ctg acg agt ctg gca gca aca tta tgg 480 Phe Pro Tyr Ile Tyr Gly Phe Leu Thr Ser Leu Ala Ala Thr Leu Trp 145 150 155 160 act tac ggc ttg tac ttc tgt gga aaa att gag atc aac cat ttc tac 528 Thr Tyr Gly Leu Tyr Phe Cys Gly Lys Ile Glu Ile Asn His Phe Tyr 165 170 175 tgt gca gat cca cct ctc atc aaa atg gcc tgt gct ggg acc ttt gta 576 Cys Ala Asp Pro Pro Leu Ile Lys Met Ala Cys Ala Gly Thr Phe Val 180 185 190 aaa gaa tat aca atg atc ata ctt gcc ggc att aac ttc aca tat tcc 624 Lys Glu Tyr Thr Met Ile Ile Leu Ala Gly Ile Asn Phe Thr Tyr Ser 195 200 205 ctg act gta att atc atc tct tac tta ttc atc ctc att gcc att ctg 672 Leu Thr Val Ile Ile Ile Ser Tyr Leu Phe Ile Leu Ile Ala Ile Leu 210 215 220 cga atg cgc tca gca gaa gga agg cag aag gcc ttt tcc aca tgt ggg 720 Arg Met Arg Ser Ala Glu Gly Arg Gln Lys Ala Phe Ser Thr Cys Gly 225 230 235 240 tcc cat ctg aca gct gtc att ata ttc tat ggt act ctg atc ttc atg 768 Ser His Leu Thr Ala Val Ile Ile Phe Tyr Gly Thr Leu Ile Phe Met 245 250 255 tat ctc aga cgt ccc aca gag gag tct gtg gag cag ggg aag atg gtg 816 Tyr Leu Arg Arg Pro Thr Glu Glu Ser Val Glu Gln Gly Lys Met Val 260 265 270 gct gtg ttc tat acc aca gtg atc ccc atg ttg aat ccc atg atc tac 864 Ala Val Phe Tyr Thr Thr Val Ile Pro Met Leu Asn Pro Met Ile Tyr 275 280 285 agt ctg agg aac aag gat gtg aaa aag gcc atg atg aaa gtg atc agc 912 Ser Leu Arg Asn Lys Asp Val Lys Lys Ala Met Met Lys Val Ile Ser 290 295 300 aga tca tgt taa 924 Arg Ser Cys 305 <210> 424 <211> 307 <212> PRT <213> Homo sapiens <400> 424 Met Leu Asn Phe Thr Asp Val Thr Glu Phe Ile Leu Leu Gly Leu Thr 1 5 10 15 Ser Arg Arg Glu Trp Gln Val Leu Phe Phe Ile Ile Phe Leu Val Val 20 25 30 Tyr Ile Ile Thr Met Val Gly Asn Ile Gly Met Met Val Leu Ile Lys 35 40 45 Val Ser Pro Gln Leu Asn Asn Pro Met Tyr Phe Phe Leu Ser His Leu 50 55 60 Ser Phe Val Asp Val Trp Phe Ser Ser Asn Val Thr Pro Lys Met Leu 65 70 75 80 Glu Asn Leu Leu Ser Asp Lys Lys Thr Ile Thr Tyr Ala Gly Cys Leu 85 90 95 Val Gln Cys Phe Phe Phe Ile Ala Leu Val His Val Glu Ile Phe Ile 100 105 110 Leu Ala Ala Met Ala Phe Asp Arg Tyr Met Ala Ile Gly Asn Pro Leu 115 120 125 Leu Tyr Gly Ser Lys Met Ser Arg Val Val Cys Ile Arg Leu Ile Thr 130 135 140 Phe Pro Tyr Ile Tyr Gly Phe Leu Thr Ser Leu Ala Ala Thr Leu Trp 145 150 155 160 Thr Tyr Gly Leu Tyr Phe Cys Gly Lys Ile Glu Ile Asn His Phe Tyr 165 170 175 Cys Ala Asp Pro Pro Leu Ile Lys Met Ala Cys Ala Gly Thr Phe Val 180 185 190 Lys Glu Tyr Thr Met Ile Ile Leu Ala Gly Ile Asn Phe Thr Tyr Ser 195 200 205 Leu Thr Val Ile Ile Ile Ser Tyr Leu Phe Ile Leu Ile Ala Ile Leu 210 215 220 Arg Met Arg Ser Ala Glu Gly Arg Gln Lys Ala Phe Ser Thr Cys Gly 225 230 235 240 Ser His Leu Thr Ala Val Ile Ile Phe Tyr Gly Thr Leu Ile Phe Met 245 250 255 Tyr Leu Arg Arg Pro Thr Glu Glu Ser Val Glu Gln Gly Lys Met Val 260 265 270 Ala Val Phe Tyr Thr Thr Val Ile Pro Met Leu Asn Pro Met Ile Tyr 275 280 285 Ser Leu Arg Asn Lys Asp Val Lys Lys Ala Met Met Lys Val Ile Ser 290 295 300 Arg Ser Cys 305 <210> 425 <211> 945 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(945) <400> 425 atg gag aat aat aca gag gtg agt gaa ttc atc ctg ctt ggt cta acc 48 Met Glu Asn Asn Thr Glu Val Ser Glu Phe Ile Leu Leu Gly Leu Thr 1 5 10 15 aat gcc cca gaa cta cag gtt ccc ctc ttt atc atg ttt acc ctc atc 96 Asn Ala Pro Glu Leu Gln Val Pro Leu Phe Ile Met Phe Thr Leu Ile 20 25 30 tac ctc atc act ctg act ggg aac ctg ggg atg atc ata tta atc ctg 144 Tyr Leu Ile Thr Leu Thr Gly Asn Leu Gly Met Ile Ile Leu Ile Leu 35 40 45 ctg gac tct cat ctc cac act ccc atg tac ttt ttt ctc agt aac ctg 192 Leu Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu 50 55 60 tct ctt gca ggc att ggt tac tcc tca gct gtc act cca aag gtt tta 240 Ser Leu Ala Gly Ile Gly Tyr Ser Ser Ala Val Thr Pro Lys Val Leu 65 70 75 80 act ggg ttg ctt ata gaa gac aaa gcc atc tcc tac agt gcc tgt gct 288 Thr Gly Leu Leu Ile Glu Asp Lys Ala Ile Ser Tyr Ser Ala Cys Ala 85 90 95 gct cag atg ttc ttt tgt gca gtc ttt gcc act gtg gaa aat tac ctc 336 Ala Gln Met Phe Phe Cys Ala Val Phe Ala Thr Val Glu Asn Tyr Leu 100 105 110 ttg tcc tca atg gcc tat gac cgc tac gca gca gtg tgt aac ccc cta 384 Leu Ser Ser Met Ala Tyr Asp Arg Tyr Ala Ala Val Cys Asn Pro Leu 115 120 125 cat tat acc acc acc atg aca aca cgt gtg tgt gct tgt ctg gct ata 432 His Tyr Thr Thr Thr Met Thr Thr Arg Val Cys Ala Cys Leu Ala Ile 130 135 140 ggc tgt tat gtc att ggt ttt ctg aat gct tct atc caa att gga gat 480 Gly Cys Tyr Val Ile Gly Phe Leu Asn Ala Ser Ile Gln Ile Gly Asp 145 150 155 160 aca ttt cgc ctc tct ttc tgc atg tcc aat gtg att cat cac ttt ttc 528 Thr Phe Arg Leu Ser Phe Cys Met Ser Asn Val Ile His His Phe Phe 165 170 175 tgt gac aaa cca gca gtc att act ctg acc tgc tct gag aaa cac att 576 Cys Asp Lys Pro Ala Val Ile Thr Leu Thr Cys Ser Glu Lys His Ile 180 185 190 agt gag ttg att ctt gtt ctt ata tca agt ttt aat gtc ttt ttt gca 624 Ser Glu Leu Ile Leu Val Leu Ile Ser Ser Phe Asn Val Phe Phe Ala 195 200 205 ctt ctt gtt acc ttg att tcc tat ctg ttc ata ttg atc acc att ctt 672 Leu Leu Val Thr Leu Ile Ser Tyr Leu Phe Ile Leu Ile Thr Ile Leu 210 215 220 aag agg cac aca ggt aag gga tac cag aag cct tta tct acc tgt ggt 720 Lys Arg His Thr Gly Lys Gly Tyr Gln Lys Pro Leu Ser Thr Cys Gly 225 230 235 240 tct cac ctc att gcc att ttc tta ttt tat ata act gtc atc atc atg 768 Ser His Leu Ile Ala Ile Phe Leu Phe Tyr Ile Thr Val Ile Ile Met 245 250 255 tac ata cga cca agt tcc agt cat tcc atg gac aca gac aaa att gca 816 Tyr Ile Arg Pro Ser Ser Ser His Ser Met Asp Thr Asp Lys Ile Ala 260 265 270 tct gtg ttc tac act atg atc atc ccc atg ctc agt cct ata gtc tat 864 Ser Val Phe Tyr Thr Met Ile Ile Pro Met Leu Ser Pro Ile Val Tyr 275 280 285 acc ctg agg aac aaa gac gtg aag aat gca ttc atg aag gtt gtt gag 912 Thr Leu Arg Asn Lys Asp Val Lys Asn Ala Phe Met Lys Val Val Glu 290 295 300 aag gca aaa tat tct cta gat tca gtc ttt taa 945 Lys Ala Lys Tyr Ser Leu Asp Ser Val Phe 305 310 315 <210> 426 <211> 314 <212> PRT <213> Homo sapiens <400> 426 Met Glu Asn Asn Thr Glu Val Ser Glu Phe Ile Leu Leu Gly Leu Thr 1 5 10 15 Asn Ala Pro Glu Leu Gln Val Pro Leu Phe Ile Met Phe Thr Leu Ile 20 25 30 Tyr Leu Ile Thr Leu Thr Gly Asn Leu Gly Met Ile Ile Leu Ile Leu 35 40 45 Leu Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu 50 55 60 Ser Leu Ala Gly Ile Gly Tyr Ser Ser Ala Val Thr Pro Lys Val Leu 65 70 75 80 Thr Gly Leu Leu Ile Glu Asp Lys Ala Ile Ser Tyr Ser Ala Cys Ala 85 90 95 Ala Gln Met Phe Phe Cys Ala Val Phe Ala Thr Val Glu Asn Tyr Leu 100 105 110 Leu Ser Ser Met Ala Tyr Asp Arg Tyr Ala Ala Val Cys Asn Pro Leu 115 120 125 His Tyr Thr Thr Thr Met Thr Thr Arg Val Cys Ala Cys Leu Ala Ile 130 135 140 Gly Cys Tyr Val Ile Gly Phe Leu Asn Ala Ser Ile Gln Ile Gly Asp 145 150 155 160 Thr Phe Arg Leu Ser Phe Cys Met Ser Asn Val Ile His His Phe Phe 165 170 175 Cys Asp Lys Pro Ala Val Ile Thr Leu Thr Cys Ser Glu Lys His Ile 180 185 190 Ser Glu Leu Ile Leu Val Leu Ile Ser Ser Phe Asn Val Phe Phe Ala 195 200 205 Leu Leu Val Thr Leu Ile Ser Tyr Leu Phe Ile Leu Ile Thr Ile Leu 210 215 220 Lys Arg His Thr Gly Lys Gly Tyr Gln Lys Pro Leu Ser Thr Cys Gly 225 230 235 240 Ser His Leu Ile Ala Ile Phe Leu Phe Tyr Ile Thr Val Ile Ile Met 245 250 255 Tyr Ile Arg Pro Ser Ser Ser His Ser Met Asp Thr Asp Lys Ile Ala 260 265 270 Ser Val Phe Tyr Thr Met Ile Ile Pro Met Leu Ser Pro Ile Val Tyr 275 280 285 Thr Leu Arg Asn Lys Asp Val Lys Asn Ala Phe Met Lys Val Val Glu 290 295 300 Lys Ala Lys Tyr Ser Leu Asp Ser Val Phe 305 310 <210> 427 <211> 900 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(900) <400> 427 atg gag cca agg aaa aat gtg act gac ttt gtc ctc ttg ggc ttc aca 48 Met Glu Pro Arg Lys Asn Val Thr Asp Phe Val Leu Leu Gly Phe Thr 1 5 10 15 cag aat cca aag gag cag aaa gta ctt ttt gtt atg ttc ttg ctc ttc 96 Gln Asn Pro Lys Glu Gln Lys Val Leu Phe Val Met Phe Leu Leu Phe 20 25 30 tac att ttg acc atg gtg ggc aac ctg ctc att gta gtg acc gta act 144 Tyr Ile Leu Thr Met Val Gly Asn Leu Leu Ile Val Val Thr Val Thr 35 40 45 gtc agt gag acc ctg ggc tca cca atg tcc ttc ttt ctt gct ggc tta 192 Val Ser Glu Thr Leu Gly Ser Pro Met Ser Phe Phe Leu Ala Gly Leu 50 55 60 aca ttt ata gat atc att tat tct tca tcc att tcc ccc aga ttg att 240 T hr Phe Ile Asp Ile Ile Tyr Ser Ser Ser Ile Ser Pro Arg Leu Ile 65 70 75 80 tca gac ttg ttc ttt ggg aat aat tcc ata tcc ttc caa tct ttc atg 288 Ser Asp Leu Phe Phe Gly Asn Asn Ser Ile Ser Phe Gln Ser Phe Met 85 90 95 gcc cag ctc ttt atc gag cac ctt ttt ggt ggg tca gag gtc ttt ctc 336 Ala Gln Leu Phe Ile Glu His Leu Phe Gly Gly Ser Glu Val Phe Leu 100 105 110 ctg ttg gtg atg gcc tat gac cgc tat gtg gcc atc tgt aag ccc ttg 384 Leu Leu Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 cat tat ttg gtt atc atg aga caa tgg gtg tgt gtt ttg ctg ctg gta 432 His Tyr Leu Val Ile Met Arg Gln Trp Val Cys Val Leu Leu Leu Val 130 135 140 gtg tcc tgg gtt gga gga ttt ctg caa tca gta ttt caa ctt agc att 480 Val Ser Trp Val Gly Gly Phe Leu Gln Ser Val Phe Gln Leu Ser Ile 145 150 155 160 att tat ggg ctc cca ttc tgt ggc ccc aat gtc att gat cat ttt ttc 528 Ile Tyr Gly Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Phe Phe 165 170 175 tgt gac atg tat ccc tta ttg aaa ctg gcc tgc act gac acc cat gtt 576 Cys Asp Met Tyr Pro Leu Leu Lys Leu Ala Cys Thr Asp Thr His Val 180 185 190 att ggc ctc tta gtg gtg gcc aat gga gga ctg tct tgc act att gcg 624 Ile Gly Leu Leu Val Val Ala Asn Gly Gly Leu Ser Cys Thr Ile Ala 195 200 205 ttt ctg ctc tta ctc atc tct tat ggt gtc atc ctg cac tct cta aag 672 Phe Leu Leu Leu Leu Ile Ser Tyr Gly Val Ile Leu His Ser Leu Lys 210 215 220 aaa ctt agt cag aaa ggg agg caa aaa gcc cac tca acc tgc agt tcc 720 Lys Leu Ser Gln Lys Gly Arg Gln Lys Ala His Ser Thr Cys Ser Ser 225 230 235 240 cac atc act gtg gtt gtc ttc ttc ttt gtt cct tgt att ttt atg tgt 768 His Ile Thr Val Val Val Phe Phe Phe Val Pro Cys Ile Phe Met Cys 245 250 255 gct aga cct gct agg acc ttc tcc att gac aaa tca gtg agt gtg ttt 816 Ala Arg Pro Ala Arg Thr Phe Ser Ile Asp Lys Ser Val Ser Val Phe 260 265 270 tat aca gtc ata acc cca atg ctg aac ccc tta atc tac act ctg aga 864 Tyr Thr Val Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 aat tct gag atg aca agt gct atg aag aag ctt tag 900 Asn Ser Glu Met Thr Ser Ala Met Lys Lys Leu 290 295 300 <210> 428 <211> 299 <212> PRT <213> Homo sapiens <400> 428 Met Glu Pro Arg Lys Asn Val Thr Asp Phe Val Leu Leu Gly Phe Thr 1 5 10 15 Gln Asn Pro Lys Glu Gln Lys Val Leu Phe Val Met Phe Leu Leu Phe 20 25 30 Tyr Ile Leu Thr Met Val Gly Asn Leu Leu Ile Val Val Thr Val Thr 35 40 45 Val Ser Glu Thr Leu Gly Ser Pro Met Ser Phe Phe Leu Ala Gly Leu 50 55 60 Thr Phe Ile Asp Ile Ile Tyr Ser Ser Ser Ile Ser Pro Arg Leu Ile 65 70 75 80 Ser Asp Leu Phe Phe Gly Asn Asn Ser Ile Ser Phe Gln Ser Phe Met 85 90 95 Ala Gln Leu Phe Ile Glu His Leu Phe Gly Gly Ser Glu Val Phe Leu 100 105 110 Leu Leu Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Leu Val Ile Met Arg Gln Trp Val Cys Val Leu Leu Leu Val 130 135 140 Val Ser Trp Val Gly Gly Phe Leu Gln Ser Val Phe Gln Leu Ser Ile 145 150 155 160 Ile Tyr Gly Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Phe Phe 165 170 175 Cys Asp Met Tyr Pro Leu Leu Lys Leu Ala Cys Thr Asp Thr His Val 180 185 190 Ile Gly Leu Leu Val Val Ala Asn Gly Gly Leu Ser Cys Thr Ile Ala 195 200 205 Phe Leu Leu Leu Leu Ile Ser Tyr Gly Val Ile Leu His Ser Leu Lys 210 215 220 Lys Leu Ser Gln Lys Gly Arg Gln Lys Ala His Ser Thr Cys Ser Ser 225 230 235 240 His Ile Thr Val Val Val Phe Phe Phe Val Pro Cys Ile Phe Met Cys 245 250 255 Ala Arg Pro Ala Arg Thr Phe Ser Ile Asp Lys Ser Val Ser Val Phe 260 265 270 Tyr Thr Val Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ser Glu Met Thr Ser Ala Met Lys Lys Leu 290 295 <210> 429 <211> 948 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(948) <400> 429 atg aga cag aat aac aat att aca gaa ttt gtc ctc ctg ggc ttt tct 48 Met Arg Gln Asn Asn Asn Ile Thr Glu Phe Val Leu Leu Gly Phe Ser 1 5 10 15 cag gat cct ggt gtg caa aaa gca tta ttt gtc atg ttt tta ctc aca 96 Gln Asp Pro Gly Val Gln Lys Ala Leu Phe Val Met Phe Leu Leu Thr 20 25 30 tac ttg gtg aca gtg gtg ggg aac ctg ctc att gtg gtg gat att att 144 Tyr Leu Val Thr Val Val Gly Asn Leu Leu Ile Val Val Asp Ile Ile 35 40 45 gcc agc cct tcc ttg ggt tcc cca atg tat ttc ttc ctt gcc tgc ctg 192 Ala Ser Pro Ser Leu Gly Ser Pro Met Tyr Phe Phe Leu Ala Cys Leu 50 55 60 tca ttt ata gat gct gca tat tcc act acc att tct ccc aag tta att 240 Ser Phe Ile Asp Ala Ala Tyr Ser Thr Thr Ile Ser Pro Lys Leu Ile 65 70 75 80 gta ggc tta ttc tgt gat aaa aag act att tcc ttc caa ggt tgc atg 288 Val Gly Leu Phe Cys Asp Lys Lys Thr Ile Ser Phe Gln Gly Cys Met 85 90 95 ggc cag cta ttt ata gac cat ttc ttt ggt ggg gct gag gtc ttc ctt 336 Gly Gln Leu Phe Ile Asp His Phe Phe Gly Gly Ala Glu Val Phe Leu 100 105 110 ctg gtg gtg atg gcc tgt gat cgc tat gtg gcc atc tgt aag cca ctg 384 Leu Val Val Met Ala Cys Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 cac tat ttg acc atc atg aat cga cag gtt tgc ttc ctt ctg ttg gtg 432 His Tyr Leu Thr Ile Met Asn Arg Gln Val Cys Phe Leu Leu Leu Val 130 135 140 gtg gcc atg att gga ggt ttt gta cat tct gcg ttt caa att gtt gtg 480 Val Ala Met Ile Gly Gly Phe Val His Ser Ala Phe Gln Ile Val Val 145 150 155 160 tac agt ctc cct atc tgt ggt ccc aat gtc att gtt cat ttc agt tgt 528 Tyr Ser Leu Pro Ile Cys Gly Pro Asn Val Ile Val His Phe Ser Cys 165 170 175 gac atg cac cca tta ctg gaa ctg gca tgc act gac acc tac ttt ata 576 Asp Met His Pro Leu Leu Glu Leu Ala Cys Thr Asp Thr Tyr Phe Ile 180 185 190 ggc ctc act gtt gtt gtc aat agt gga gca atc tgt atg gtc att ttc 624 Gly Leu Thr Val Val Val Asn Ser Gly Ala Ile Cys Met Val Ile Phe 195 200 205 aac ctt ctg tta atc tcc tat gga gtc atc cta agc tcc ctt aaa act 672 Asn Leu Leu Leu Ile Ser Tyr Gly Val Ile Leu Ser Ser Leu Lys Thr 210 215 220 tac agt cag gaa aag agg ggt aaa gcc ttg tct acc tgc agc tcc ggc 720 Tyr Ser Gln Glu Lys Arg Gly Lys Ala Leu Ser Thr Cys Ser Ser Gly 225 230 235 240 agt acc gtt gtt gtc ctc ttt ttt gta ccc tgt att ttc ata tat gtt 768 Se r Thr Val Val Val Leu Phe Phe Val Pro Cys Ile Phe Ile Tyr Val 245 250 255 aga cct gtt tca aac ttt cct act gat aag ttc atg act gtg ttt tat 816 Arg Pro Val Ser Asn Phe Pro Thr Asp Lys Phe Met Thr Val Phe Tyr 260 265 270 acc att atc aca cac atg ctg agt cct tta ata tat acg ttg aga aat 864 Thr Ile Ile Thr His Met Leu Ser Pro Leu Ile Tyr Thr Leu Arg Asn 275 280 285 tca gag atg aga aat gct ata gaa aaa ctc ttg ggt aaa aag tta act 912 Ser Glu Met Arg Asn Ala Ile Glu Lys Leu Leu Gly Lys Lys Leu Thr 290 295 300 ata ttt att ata gga gga gtg tcc gtc ctc atg tag 948 Ile Phe Ile Ile Gly Gly Val Ser Val Leu Met 305 310 315 <210> 430 <211> 315 <212> PRT <213> Homo sapiens <400> 430 Met Arg Gln Asn Asn Asn Ile Thr Glu Phe Val Leu Leu Gly Phe Ser 1 5 10 15 Gln Asp Pro Gly Val Gln Lys Ala Leu Phe Val Met Phe Leu Leu Thr 20 25 30 Tyr Leu Val Thr Val Val Gly Asn Leu Leu Ile Val Val Asp Ile Ile 35 40 45 Ala Ser Pro Ser Leu Gly Ser Pro Met Tyr Phe Phe Leu Ala Cys Leu 50 55 60 Ser Phe Ile Asp Ala Ala Tyr Ser Thr Thr Ile Ser Pro Lys Leu Ile 65 70 75 80 Val Gly Leu Phe Cys Asp Lys Lys Thr Ile Ser Phe Gln Gly Cys Met 85 90 95 Gly Gln Leu Phe Ile Asp His Phe Phe Gly Gly Ala Glu Val Phe Leu 100 105 110 Leu Val Val Met Ala Cys Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Leu Thr Ile Met Asn Arg Gln Val Cys Phe Leu Leu Leu Val 130 135 140 Val Ala Met Ile Gly Gly Phe Val His Ser Ala Phe Gln Ile Val Val 145 150 155 160 Tyr Ser Leu Pro Ile Cys Gly Pro Asn Val Ile Val His Phe Ser Cys 165 170 175 Asp Met His Pro Leu Leu Glu Leu Ala Cys Thr Asp Thr Tyr Phe Ile 180 185 190 Gly Leu Thr Val Val Val Asn Ser Gly Ala Ile Cys Met Val Ile Phe 195 200 205 Asn Leu Leu Leu Ile Ser Tyr Gly Val Ile Leu Ser Ser Leu Lys Thr 210 215 220 Tyr Ser Gln Glu Lys Arg Gly Lys Ala Leu Ser Thr Cys Ser Ser Gly 225 230 235 240 Ser Thr Val Val Val Leu Phe Phe Val Pro Cys Ile Phe Ile Tyr Val 245 250 255 Arg Pro Val Ser Asn Phe Pro Thr Asp Lys Phe Met Thr Val Phe Tyr 260 265 270 Thr Ile Ile Thr His Met Leu Ser Pro Leu Ile Tyr Thr Leu Arg Asn 275 280 285 Ser Glu Met Arg Asn Ala Ile Glu Lys Leu Leu Gly Lys Lys Leu Thr 290 295 300 Ile Phe Ile Ile Gly Gly Val Ser Val Leu Met 305 310 315 <210> 431 <211> 801 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(801) <400> 431 atg atc aca ctg att ggg ctc agt tct cac ctg cac aca cct atg tac 48 Met Ile Thr Leu Ile Gly Leu Ser Ser His Leu His Thr Pro Met Tyr 1 5 10 15 tat ttc ctc agc agt ctg tcc ttc att gac ttc tgc cat tcc act gtc 96 Tyr Phe Leu Ser Ser Leu Ser Phe Ile Asp Phe Cys His Ser Thr Val 20 25 30 att acc cct aag atg ctg gtg aac ttt gcg aca gag aag aac atc atc 144 Ile Thr Pro Lys Met Leu Val Asn Phe Ala Thr Glu Lys Asn Ile Ile 35 40 45 tcc tac cct gaa tgc atg gct cag ctc tat tta ttc agt att ttt gct 192 Ser Tyr Pro Glu Cys Met Ala Gln Leu Tyr Leu Phe Ser Ile Phe Ala 50 55 60 att gca gag tgt cac atg ttg gct gca atg gcg tat gac tgt tat gtt 240 Ile Ala Glu Cys His Met Leu Ala Ala Met Ala Tyr Asp Cys Tyr Val 65 70 75 80 gcc atc tgc agc ccc ttg ctg tac aat gtc atc atg tcc tat cac cac 288 Ala Ile Cys Ser Pro Leu Leu Tyr Asn Val Ile Met Ser Tyr His His 85 90 95 tgc ttc tgg ctc aca gtg gga gtt tac att tta ggc atc ctt gga tct 336 Cys Phe Trp Leu Thr Val Gly Val Tyr Ile Leu Gly Ile Leu Gly Ser 100 105 110 aca att cat acc agt ttt atg ttg aga ctc ttt ttg tgc aag act aat 384 Thr Ile His Thr Ser Phe Met Leu Arg Leu Phe Leu Cys Lys Thr Asn 115 120 125 gtg att aac cat tat ttt tgt gat ctt ttc cct ctc ttg ggg ctc tcc 432 Val Ile Asn His Tyr Phe Cys Asp Leu Phe Pro Leu Leu Gly Leu Ser 130 135 140 tgc tcc agc acc tac atc aat gaa tta ctg gtt ctg gtc ttg agt gca 480 Cys Ser Ser Thr Tyr Ile Asn Glu Leu Leu Val Leu Val Leu Ser Ala 145 150 155 160 ttt aac atc ctg atg cct gcc tta acc atc ctt gct tct tac atc ttt 528 Phe Asn Ile Leu Met Pro Ala Leu Thr Ile Leu Ala Ser Tyr Ile Phe 165 170 175 atc att gcc agc atc ctc cgc att cac tcc act gag ggc agg tcc aaa 576 Ile Ile Ala Ser Ile Leu Arg Ile His Ser Thr Glu Gly Arg Ser Lys 180 185 190 gcc ttc agc act tgc agc tcc cac atc ttg gct gtt gct gtt ttc ttt 624 Ala Phe Ser Thr Cys Ser Ser His Ile Leu Ala Val Ala Val Phe Phe 195 200 205 gga tct gca gca ttc atg tac ctg cag cca tca tct gtc agc tcc atg 672 Gly Ser Ala Ala Phe Met Tyr Leu Gln Pro Ser Ser Val Ser Ser Met 210 215 220 gac cag agg aaa gtg tcg tct gtg ttt tat act act att gtg ccc atg 720 Asp Gln Arg Lys Val Ser Ser Val Phe Tyr Thr Thr Ile Val Pro Met 225 230 235 240 ctg aac ccc ctg atc tac agc ctg agg aat aaa gat gtc aaa ctt gcc 768 Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Leu Ala 245 250 255 gtg aag aaa att ctg cat cag aca gca tgt taa 801 Val Lys Lys Ile Leu His Gln Thr Ala Cys 260 265 <210> 432 <211> 266 <212> PRT <213> Homo sapiens <400> 432 Met Ile Thr Leu Ile Gly Leu Ser Ser His Leu His Thr Pro Met Tyr 1 5 10 15 Tyr Phe Leu Ser Ser Leu Ser Phe Ile Asp Phe Cys His Ser Thr Val 20 25 30 Ile Thr Pro Lys Met Leu Val Asn Phe Ala Thr Glu Lys Asn Ile Ile 35 40 45 Ser Tyr Pro Glu Cys Met Ala Gln Leu Tyr Leu Phe Ser Ile Phe Ala 50 55 60 Ile Ala Glu Cys His Met Leu Ala Ala Met Ala Tyr Asp Cys Tyr Val 65 70 75 80 Ala Ile Cys Ser Pro Leu Leu Tyr Asn Val Ile Met Ser Tyr His His 85 90 95 Cys Phe Trp Leu Thr Val Gly Val Tyr Ile Leu Gly Ile Leu Gly Ser 100 105 110 Thr Ile His Thr Ser Phe Met Leu Arg Leu Phe Leu Cys Lys Thr Asn 115 120 125 Val Ile Asn His Tyr Phe Cys Asp Leu Phe Pro Leu Leu Gly Leu Ser 130 135 140 Cys Ser Ser Thr Tyr Ile Asn Glu Leu Leu Val Leu Val Leu Ser Ala 145 150 155 160 Phe Asn Ile Leu Met Pro Ala Leu Thr Ile Leu Ala Ser Tyr Ile Phe 165 170 175 Ile Ile Ala Ser Ile Leu Arg Ile His Ser Thr Glu Gly Arg Ser Lys 180 185 190 Ala Phe Ser Thr Cys Ser Ser His Ile Leu Ala Val Ala Val Phe Phe 195 200 205 Gly Ser Ala Ala Phe Met Tyr Leu Gln Pro Ser Ser Val Ser Ser Met 210 215 220 Asp Gln Arg Lys Val Ser Ser Val Phe Tyr Thr Thr Ile Val Pro Met 225 230 235 240 Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Leu Ala 245 250 255 Val Lys Lys Ile Leu His Gln Thr Ala Cys 260 265 <210> 433 <211> 939 <212> DNA <213> Homo sapiens <2 20> <221> CDS <222> (1)..(939) <400> 433 atg aga aat ggc aca gta atc aca gaa ttc atc ctg cta ggc ttt cct 48 Met Arg Asn Gly Thr Val Ile Thr Glu Phe Ile Leu Leu Gly Phe Pro 1 5 10 15 gtt atc caa ggc cta caa aca cct ctc ttt att gca atc ttt ctc acc 96 Val Ile Gln Gly Leu Gln Thr Pro Leu Phe Ile Ala Ile Phe Leu Thr 20 25 30 tac ata tta acc ctt gca ggc aat ggg ctt att att gcc act gtg tgg 144 Tyr Ile Leu Thr Leu Ala Gly Asn Gly Leu Ile Ile Ala Thr Val Trp 35 40 45 gct gag ccc agg cta caa att cca atg tac ttc ttc ctt tgt aac ttg 192 Ala Glu Pro Arg Leu Gln Ile Pro Met Tyr Phe Phe Leu Cys Asn Leu 50 55 60 tct ttc tta gaa atc tgg tac acc acc aca gtc atc ccc aaa ctg cta 240 Ser Phe Leu Glu Ile Trp Tyr Thr Thr Thr Val Ile Pro Lys Leu Leu 65 70 75 80 gga acc ttt gta gtg gca aga aca gta atc tgc atg tcc tgc tgc ctg 288 Gly Thr Phe Val Val Ala Arg Thr Val Ile Cys Met Ser Cys Cys Leu 85 90 95 ctg cag gcc ttc ttc cac ttc ttc gtg ggc acc acc gag ttc ttg atc 336 Leu Gln Ala Phe Phe His Phe Phe Val Gly Thr Thr Glu Phe Leu Ile 100 105 110 ctc act atc atg tct ttt gac cgc tac ctc acc atc tgc aat ccc ctt 384 Leu Thr Ile Met Ser Phe Asp Arg Tyr Leu Thr Ile Cys Asn Pro Leu 115 120 125 cac cac ccc acc atc atg acc agc aaa ctc tgc ctg cag ctg gcc ctg 432 His His Pro Thr Ile Met Thr Ser Lys Leu Cys Leu Gln Leu Ala Leu 130 135 140 agc tcc tgg gtg gtg ggc ttc acc att gtc ttt tgt cag acg atg ctg 480 Ser Ser Trp Val Val Gly Phe Thr Ile Val Phe Cys Gln Thr Met Leu 145 150 155 160 ctc atc cag ttg cca ttc tgt ggc aat aat gtt atc agt cat ttc tac 528 Leu Ile Gln Leu Pro Phe Cys Gly Asn Asn Val Ile Ser His Phe Tyr 165 170 175 tgt gat gtt ggg ccc agt ttg aaa gcc gcc tgc ata gac acc agc att 576 Cys Asp Val Gly Pro Ser Leu Lys Ala Ala Cys Ile Asp Thr Ser Ile 180 185 190 ttg gaa ctc ctg ggc gtc ata gca acc atc ctt gtg atc cca ggg tca 624 Leu Glu Leu Leu Gly Val Ile Ala Thr Ile Leu Val Ile Pro Gly Ser 195 200 205 ctt ctc ttt aat atg att tct tat atc tac att ctg tcc gca atc cta 672 Leu Leu Phe Asn Met Ile Ser Tyr Ile Tyr Ile Leu Ser Ala Ile Leu 210 215 220 cga att cct tca gcc act ggc cac caa aag act ttc tct acc tgt gcc 720 Arg Ile Pro Ser Ala Thr Gly His Gln Lys Thr Phe Ser Thr Cys Ala 225 230 235 240 tcg cac ctg aca gtt gtc tcc ctg ctc tac ggg gct gtt ctg ttc atg 768 Ser His Leu Thr Val Val Ser Leu Leu Tyr Gly Ala Val Leu Phe Met 245 250 255 tac cta aga ccc aca gca cac tcc tcc ttt aag att aat aag gtg gtg 816 Tyr Leu Arg Pro Thr Ala His Ser Ser Phe Lys Ile Asn Lys Val Val 260 265 270 tct gtg cta aat act atc ctc acc ccc ctt ctg aat ccc ttt att tat 864 Ser Val Leu Asn Thr Ile Leu Thr Pro Leu Leu Asn Pro Phe Ile Tyr 275 280 285 act att aga aac aag gag gtg aag gga gcc tta aga aag gca atg act 912 Thr Ile Arg Asn Lys Glu Val Lys Gly Ala Leu Arg Lys Ala Met Thr 290 295 300 tgc cca aag act ggt cat gca aag taa 939 Cys Pro Lys Thr Gly His Ala Lys 305 310 <210> 434 <211> 312 <212> PRT <213> Homo sapiens <400> 434 Met Arg Asn Gly Thr Val Ile Thr Glu Phe Ile Leu Leu Gly Phe Pro 1 5 10 15 Val Ile Gln Gly Leu Gln Thr Pro Leu Phe Ile Ala Ile Phe Leu Thr 20 25 30 Tyr Ile Leu Thr Leu Ala Gly Asn Gly Leu Ile Ile Ala Thr Val Trp 35 40 45 Ala Glu Pro Arg Leu Gln Ile Pro Met Tyr Phe Phe Leu Cys Asn Leu 50 55 60 Ser Phe Leu Glu Ile Trp Tyr Thr Thr Thr Val Ile Pro Lys Leu Leu 65 70 75 80 Gly Thr Phe Val Val Ala Arg Thr Val Ile Cys Met Ser Cys Cys Leu 85 90 95 Leu Gln Ala Phe Phe His Phe Phe Val Gly Thr Thr Glu Phe Leu Ile 100 105 110 Leu Thr Ile Met Ser Phe Asp Arg Tyr Leu Thr Ile Cys Asn Pro Leu 115 120 125 His His Pro Thr Ile Met Thr Ser Lys Leu Cys Leu Gln Leu Ala Leu 130 135 140 Ser Ser Trp Val Val Gly Phe Thr Ile Val Phe Cys Gln Thr Met Leu 145 150 155 160 Leu Ile Gln Leu Pro Phe Cys Gly Asn Asn Val Ile Ser His Phe Tyr 165 170 175 Cys Asp Val Gly Pro Ser Leu Lys Ala Ala Cys Ile Asp Thr Ser Ile 180 185 190 Leu Glu Leu Leu Gly Val Ile Ala Thr Ile Leu Val Ile Pro Gly Ser 195 200 205 Leu Leu Phe Asn Met Ile Ser Tyr Ile Tyr Ile Leu Ser Ala Ile Leu 210 215 220 Arg Ile Pro Ser Ala Thr Gly His Gln Lys Thr Phe Ser Thr Cys Ala 225 230 235 240 Ser His Leu Thr Val Val Ser Leu Leu Tyr Gly Ala Val Leu Phe Met 245 250 255 Tyr Leu Arg Pro Thr Ala His Ser Ser Phe Lys Ile Asn Lys Val Val 260 265 270 Ser Val Leu Asn Thr Ile Leu Thr Pro Leu Leu Asn Pro Phe Ile Tyr 275 280 285 Thr Ile Arg Asn Lys Glu Val Lys Gly Ala Leu Arg Lys Ala Met Thr 290 295 300 Cys Pro Lys Thr Gly His Ala Lys 305 310 <210> 435 <211> 942 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(942) <400> 435 atg gga aac tgg agc act gtg act gaa atc acc cta att gcc ttc cca 48 Met Gly Asn Trp Ser Thr Val Thr Glu Ile Thr Leu Ile Ala Phe Pro 1 5 10 15 gct ctc ctg gag att cga ata tct ctc ttc gtg gtt ctt gtg gta act 96 Ala Leu Leu Glu Ile Arg Ile Ser Leu Phe Val Val Leu Val Val Thr 20 25 30 tac aca tta aca gca aca gga aac atc acc atc atc tcc ctg ata tgg 144 Tyr Thr Leu Thr Ala Thr Gly Asn Ile Thr Ile Ile Ser Leu Ile Trp 35 40 45 att gat cat cgc ctg caa act cca atg tac ttc ttc ctc agt aat ttg 192 Ile Asp His Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu 50 55 60 tcc ttt ctg gat atc tta tac acc act gtc att acc cca aag ttg ttg 240 Ser Phe Leu Asp Ile Leu Tyr Thr Thr Val Ile Thr Pro Lys Leu Leu 65 70 75 80 gcc tgc ctc cta gga gaa gag aaa acc ata tct ttt gct ggt tgc atg 288 Ala Cys Leu Leu Gly Glu Glu Lys Thr Ile Ser Phe Ala Gly Cys Met 85 90 95 atc caa aca tat ttc tac ttc ttt ctg ggg acg gtg gag ttt atc ctc 336 Ile Gln Thr Tyr Phe Tyr Phe Phe Leu Gly Thr Val Glu Phe Ile Leu 100 105 110 ttg gcg gtg atg tcc ttt gac cgc tac atg gct atc tgc gac cca ctg 384 Leu Ala Val Met Ser Phe Asp Arg Tyr Met Ala Ile Cys Asp Pro Leu 115 120 125 cac tac acg gtc atc atg aac agc agg gcc tgc ctt ctg ctg gtt ctg 432 His Tyr Thr Val Ile Met Asn Ser Arg Ala Cys Leu Leu Leu Val Leu 130 135 140 gga tgc tgg gtg gga gcc ttc ctg tct gtg ttg ttt cca acc att gta 480 Gly Cys Trp Val Gly Ala Phe Leu Ser Val Leu Phe Pro Thr Ile Val 145 150 155 160 gtg aca agg cta cct tac tgt agg aaa gaa att aat cat ttc ttc tgt 528 Val Thr Arg Leu Pro Tyr Cys Arg Lys Glu Ile Asn His Phe Phe Cys 165 170 175 gac att gcc cct ctt ctt cag gtg gcc tgt ata aat act cac ctc att 576 Asp Ile Ala Pro Leu Leu Gln Val Ala Cys Ile Asn Thr His Leu Ile 180 185 190 gag aag ata aac ttt ctc ctc tct gcc ctt gtc atc ctg agc tcc ctg 624 Glu Lys Ile Asn Phe Leu Leu Ser Ala Leu Val Ile Leu Ser Ser Leu 195 200 205 gca ttc act act ggg tcc tac gtg tac ata att tct acc atc ctg cgt 672 Ala Phe Thr Thr Gly Ser Tyr Val Tyr Ile Ile Ser Thr Ile Leu Arg 210 215 220 atc ccc tcc acc cag ggc cgt cag aaa gct ttt tct acc tgt gct tct 720 Ile Pro Ser Thr Gln Gly Arg Gln Lys Ala Phe Ser Thr Cys Ala Ser 225 230 235 240 cac atc act gtt gtc tcc att gcc cac ggg agc aac atc ttt gtg tat 768 His Ile Thr Val Val Ser Ile Ala His Gly Ser Asn Ile Phe Val Tyr 245 250 255 gtg aga ccc aat cag aac tcc tca ctg gat tat gac aag gtg gcc gct 816 Val Arg Pro Asn Gln Asn Ser Ser Leu Asp Tyr Asp Lys Val Ala Ala 260 265 270 gtc ctc atc aca gtg gtg acc cct ctc ctg aac cct ttt atc tac agc 864 Val Leu Ile Thr Val Val Thr Pro Leu Leu Asn Pro Phe Ile Tyr Ser 275 280 285 ttg agg aat gag aag gta cag gaa gtg ttg aga gag aca gtg aac aga 912 Leu Arg Asn Glu Lys Val Gln Glu Val Leu Arg Glu Thr Val Asn Arg 290 295 300 atc atg acc ttg ata caa agg aaa act tga 942 Ile Met Thr Leu Ile Gln Arg Lys Thr 305 310 <210> 436 <211> 313 <212> PRT <213> Homo sapiens <400> 436 Met Gly Asn Trp Ser Thr Val Thr Glu Ile Thr Leu Ile Ala Phe Pro 1 5 10 15 Ala Leu Leu Glu Ile Arg Ile Ser Leu Phe Val Val Leu Val Val Thr 20 25 30 Tyr Thr Leu Thr Ala Thr Gly Asn Ile Thr Ile Ile Ser Leu Ile Trp 35 40 45 Ile Asp His Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu 50 55 60 Ser Phe Leu Asp Ile Leu Tyr Thr Thr Val Ile Thr Pro Lys Leu Leu 65 70 75 80 Ala Cys Leu Leu Gly Glu Glu Lys Thr Ile Ser Phe Ala Gly Cys Met 85 90 95 Ile Gln Thr Tyr Phe Tyr Phe Phe Leu Gly Thr Val Glu Phe Ile Leu 100 105 110 Leu Ala Val Met Ser Phe Asp Arg Tyr Met Ala Ile Cys Asp Pro Leu 115 120 125 His Tyr Thr Val Ile Met Asn Ser Arg Ala Cys Leu Leu Leu Val Leu 130 135 140 Gly Cys Trp Val Gly Ala Phe Leu Ser Val Leu Phe Pro Thr Ile Val 145 150 155 160 Val Thr Arg Leu Pro Tyr Cys Arg Lys Glu Ile Asn His Phe Phe Cys 165 170 175 Asp Ile Ala Pro Leu Leu Gln Val Ala Cys Ile Asn Thr His Leu Ile 180 185 190 Glu Lys Ile Asn Phe Leu Leu Ser Ala Leu Val Ile Leu Ser Ser Leu 195 200 205 Ala Phe Thr Thr Gly Ser Tyr Val Tyr Ile Ile Ser Thr Ile Leu Arg 210 215 220 Ile Pro Ser Thr Gln Gly Arg Gln Lys Ala Phe Ser Thr Cys Ala Ser 225 230 235 240 His Ile Thr Val Val Ser Ile Ala His Gly Ser Asn Ile Phe Val Tyr 245 250 255 Val Arg Pro Asn Gln Asn Ser Ser Leu Asp Tyr Asp Lys Val Ala Ala 260 265 270 Val Leu Ile Thr Val Val Thr Pro Leu Leu Asn Pro Phe Ile Tyr Ser 275 280 285 Leu Arg Asn Glu Lys Val Gln Glu Val Leu Arg Glu Thr Val Asn Arg 290 295 300 Ile Met Thr Leu Ile Gln Arg Lys Thr 305 310 <210> 437 <211> 930 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(930) <400> 437 atg gag aat tgt acg gaa gtg aca aag ttc att ctt cta gga cta acc 48 Met Glu Asn Cys Thr Glu Val Thr Lys Phe Ile Leu Leu Gly Leu Thr 1 5 10 15 agt gtc cca gaa cta cag atc ccc ctc ttt atc ttg ttc acc ttc atc 96 Ser Val Pro Glu Leu Gln Ile Pro Leu Phe Ile Leu Phe Thr Phe Ile 20 25 30 tac ctc ctc act ctg tgt ggg aac ctg ggg atg atg ttg ctg atc ctg 144 Tyr Leu Leu Thr Leu Cys Gly Asn Leu Gly Met Met Leu Leu Ile Leu 35 40 45 atg gac tct tgt ctc cac acc ccc atg tac ttt ttc ctc agt aac ctg 192 Met Asp Ser Cys Leu His Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu 50 55 60 tct ctg gtg gac ttt gga tac tcc tca gct gtc act ccc aag gtc atg 240 Ser Leu Val Asp Phe Gly Tyr Ser Ser Ala Val Thr Pro Lys Val Met 65 70 75 80 gct ggg ttc ctt aga gga gac aag gtc atc tcc tac aat gca tgt gct 288 Ala Gly Phe Leu Arg Gly Asp Lys Val Ile Ser Tyr Asn Ala Cys Ala 85 90 95 gtt cag atg ttc ttc ttt gta gcc ttg gcc acg gtg gaa aat tac ttg 336 Val Gln Met Phe Phe Phe Val Ala Leu Ala Thr Val Glu Asn Tyr Leu 100 105 110 ttg gcc tca atg gcc tat gac cgc tat gca gca gtg tgc aaa ccc cta 384 Leu Ala Ser Met Ala Tyr Asp Arg Tyr Ala Ala Val Cys Lys Pro Leu 115 120 125 cac tac acc acc acc atg acg gcc agt gta ggt gcc tgt ctg gcc cta 432 His Tyr Thr Thr Thr Met Thr Ala Ser Val Gly Ala Cys Leu Ala Leu 130 135 140 ggc tca tat gtc tgt ggc ttc cta aat gcc tca ttc cac att ggg ggc 480 Gly Ser Tyr Val Cys Gly Phe Leu Asn Ala Ser Phe His Ile Gly Gly 145 150 155 160 ata ttc agt ctc tct ttc tgt aaa tcc aat ctg gta cat cac ttt ttc 528 Ile Phe Ser Leu Ser Phe Cys Lys Ser Asn Leu Val His His Phe Phe 165 170 175 tgt gat gtt cca gca gtc atg gct ctg tct tgc tct gat aaa cac act 576 Cys Asp Val Pro Ala Val Met Ala Leu Ser Cys Ser Asp Lys His Thr 180 185 190 agt gag gtg att ctg gtt ttt atg tca agc ttt aat atc ttt ttt gtt 624 Ser Glu Val Ile Leu Val Phe Met Ser Ser Phe Asn Ile Phe Phe Val 195 200 205 ctt cta gtt atc ttt atc tcc tac ttg ttc ata ttc atc acc atc ttg 672 Leu Leu Val Ile Phe Ile Ser Tyr Leu Phe Ile Phe Ile Thr Ile Leu 210 215 220 aag atg cat tca gct aag gga cac caa aaa gca ttg tcc acc tgt gcc 720 Lys Met His Ser Ala Lys Gly His Gln Lys Ala Leu Ser Thr Cys Ala 225 230 235 240 tct cac ttc act gca gtc tcc gtc ttc tat ggg aca gta atc ttc atc 768 Ser His Phe Thr Ala Val Ser Val Phe Tyr Gly Thr Val Ile Phe Ile 245 250 255 tac ttg cag ccc agc tcc agc cac tcc atg gac aca gac aaa atg gca 816 Tyr Leu Gln Pro Ser Ser Ser His Ser Met Asp Thr Asp Lys Met Ala 260 265 270 tct gtg ttc tat gct atg atc atc ccc atg ctg aac cct gtg gtc tac 864 Ser Val Phe Tyr Ala Met Ile Ile Pro Met Leu Asn Pro Val Val Tyr 275 280 285 agc ctg agg aac aga gaa gtc cag aat gca ttc aag aaa gtg ttg aga 912 Ser Leu Arg Asn Arg Glu Val Gln Asn Ala Phe Lys Lys Val Leu Arg 290 295 300 agg caa aaa ttt cta taa 930 Arg Gln Lys Phe Leu 305 310 <210> 438 <211> 309 <212> PRT <213> Homo sapiens <400> 438 Me t Glu Asn Cys Thr Glu Val Thr Lys Phe Ile Leu Leu Gly Leu Thr 1 5 10 15 Ser Val Pro Glu Leu Gln Ile Pro Leu Phe Ile Leu Phe Thr Phe Ile 20 25 30 Tyr Leu Leu Thr Leu Cys Gly Asn Leu Gly Met Met Leu Leu Ile Leu 35 40 45 Met Asp Ser Cys Leu His Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu 50 55 60 Ser Leu Val Asp Phe Gly Tyr Ser Ser Ala Val Thr Pro Lys Val Met 65 70 75 80 Ala Gly Phe Leu Arg Gly Asp Lys Val Ile Ser Tyr Asn Ala Cys Ala 85 90 95 Val Gln Met Phe Phe Phe Val Ala Leu Ala Thr Val Glu Asn Tyr Leu 100 105 110 Leu Ala Ser Met Ala Tyr Asp Arg Tyr Ala Ala Val Cys Lys Pro Leu 115 120 125 His Tyr Thr Thr Thr Met Thr Ala Ser Val Gly Ala Cys Leu Ala Leu 130 135 140 Gly Ser Tyr Val Cys Gly Phe Leu Asn Ala Ser Phe His Ile Gly Gly 145 150 155 160 Ile Phe Ser Leu Ser Phe Cys Lys Ser Asn Leu Val His His Phe Phe 165 170 175 Cys Asp Val Pro Ala Val Met Ala Leu Ser Cys Ser Asp Lys His Thr 180 185 190 Ser Glu Val Ile Leu Val Phe Met Ser Ser Phe Asn Ile Phe Phe Val 195 200 205 Leu Leu Val Ile Phe Ile Ser Tyr Leu Phe Ile Phe Ile Thr Ile Leu 210 215 220 Lys Met His Ser Ala Lys Gly His Gln Lys Ala Leu Ser Thr Cys Ala 225 230 235 240 Ser His Phe Thr Ala Val Ser Val Phe Tyr Gly Thr Val Ile Phe Ile 245 250 255 Tyr Leu Gln Pro Ser Ser Ser His Ser Met Asp Thr Asp Lys Met Ala 260 265 270 Ser Val Phe Tyr Ala Met Ile Ile Pro Met Leu Asn Pro Val Val Tyr 275 280 285 Ser Leu Arg Asn Arg Glu Val Gln Asn Ala Phe Lys Lys Val Leu Arg 290 295 300 Arg Gln Lys Phe Leu 305 <210> 439 <211> 945 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(945) <400> 439 atg gaa aat aag aca gaa gta aca caa ttc att ctt cta gga cta acc 48 Met Glu Asn Lys Thr Glu Val Thr Gln Phe Ile Leu Leu Gly Leu Thr 1 5 10 15 aat gac tca gaa ctg cag gtt ccc ctc ttt ata acg ttc ccc ttc atc 96 Asn Asp Ser Glu Leu Gln Val Pro Leu Phe Ile Thr Phe Pro Phe Ile 20 25 30 tat att atc act ctg gtt gga aac ctg gga att att gta ttg ata ttc 144 Tyr Ile Ile Thr Leu Val Gly Asn Leu Gly Ile Ile Val Leu Ile Phe 35 40 45 tgg gat tcc tgt ctc cac aat ccc atg tac ttt ttt ctc agt aac ttg 192 Trp Asp Ser Cys Leu His Asn Pro Met Tyr Phe Phe Leu Ser Asn Leu 50 55 60 tct cta gtg gac ttt tgc tac tct tca gct gtc act ccc atc gtc atg 240 Ser Leu Val Asp Phe Cys Tyr Ser Ser Ala Val Thr Pro Ile Val Met 65 70 75 80 gct gga ttc ctt ata gaa gac aag gtc atc tct tac aat gca tgt gct 288 Ala Gly Phe Leu Ile Glu Asp Lys Val Ile Ser Tyr Asn Ala Cys Ala 85 90 95 gct caa atg tat atc ttt gta gct ttt gcc act gtg gaa aat tac ctc 336 Ala Gln Met Tyr Ile Phe Val Ala Phe Ala Thr Val Glu Asn Tyr Leu 100 105 110 ttg gcc tca atg gcc tat gac cgc tat gca gca gtg tgc aaa ccc cta 384 Leu Ala Ser Met Ala Tyr Asp Arg Tyr Ala Ala Val Cys Lys Pro Leu 115 120 125 cat tac acc aca acc atg aca aca act gtg tgt gct cgt ctg gcc ata 432 His Tyr Thr Thr Thr Met Thr Thr Thr Val Cys Ala Arg Leu Ala Ile 130 135 140 ggc tcc tac ctc tgt ggt ttc ctg aat gcc tcc atc cac act ggg gac 480 Gly Ser Tyr Leu Cys Gly Phe Leu Asn Ala Ser Ile His Thr Gly Asp 145 150 155 160 aca ttt agt ctc tct ttc tgt aag tcc aat gaa gtc cat cac ttt ttc 528 Thr Phe Ser Leu Ser Phe Cys Lys Ser Asn Glu Val His His Phe Phe 165 170 175 tgt gat att cca gca gtc atg gtt ctc tct tgc tct gat aga cat att 576 Cys Asp Ile Pro Ala Val Met Val Leu Ser Cys Ser Asp Arg His Ile 180 185 190 agc gag ctt gtt ctt att tat gtt gtg agc ttc aat atc ttt ata gct 624 Ser Glu Leu Val Leu Ile Tyr Val Val Ser Phe Asn Ile Phe Ile Ala 195 200 205 ctc ctg gtt atc ttg ata tcc tac aca ttc att ttt atc acc atc cta 672 Leu Leu Val Ile Leu Ile Ser Tyr Thr Phe Ile Phe Ile Thr Ile Leu 210 215 220 aag atg cac tca gct tca gta tac cag aag cct ttg tcc acc tgt gcc 720 Lys Met His Ser Ala Ser Val Tyr Gln Lys Pro Leu Ser Thr Cys Ala 225 230 235 240 tct cat ttc att gca gtc ggc atc ttc tat ggg act att atc ttc atg 768 Ser His Phe Ile Ala Val Gly Ile Phe Tyr Gly Thr Ile Ile Phe Met 245 250 255 tac tta caa ccc agc tcc agt cac tcc atg gac aca gac aaa atg gca 816 Tyr Leu Gln Pro Ser Ser Ser His Ser Met Asp Thr Asp Lys Met Ala 260 265 270 cct gtg ttc tat aca atg gtc atc ccc atg ctg aac cct ctg gtc tat 864 Pro Val Phe Tyr Thr Met Val Ile Pro Met Leu Asn Pro Leu Val Tyr 275 280 285 agt ctg agg aac aag gaa gtg aag agt gca ttc aag aaa gtt gtt gag 912 Ser Leu Arg Asn Lys Glu Val Lys Ser Ala Phe Lys Lys Val Val Glu 290 295 300 aag gca aaa ttg tct gta gga tgg tca gtt taa 945 Lys Ala Lys Leu Ser Val Gly Trp Ser Val 305 310 315 <210> 440 <211> 314 <212> PRT <213> Homo sapiens <400> 440 Met Glu Asn Lys Thr Glu Val Thr Gln Phe Ile Leu Leu Gly Leu Thr 1 5 10 15 Asn Asp Ser Glu Leu Gln Val Pro Leu Phe Ile Thr Phe Pro Phe Ile 20 25 30 Tyr Ile Ile Thr Leu Val Gly Asn Leu Gly Ile Ile Val Leu Ile Phe 35 40 45 Trp Asp Ser Cys Leu His Asn Pro Met Tyr Phe Phe Leu Ser Asn Leu 50 55 60 Ser Leu Val Asp Phe Cys Tyr Ser Ser Ala Val Thr Pro Ile Val Met 65 70 75 80 Ala Gly Phe Leu Ile Glu Asp Lys Val Ile Ser Tyr Asn Ala Cys Ala 85 90 95 Ala Gln Met Tyr Ile Phe Val Ala Phe Ala Thr Val Glu Asn Tyr Leu 100 105 110 Leu Ala Ser Met Ala Tyr Asp Arg Tyr Ala Ala Val Cys Lys Pro Leu 115 120 125 His Tyr Thr Thr Thr Met Thr Thr Thr Val Cys Ala Arg Leu Ala Ile 130 135 140 Gly Ser Tyr Leu Cys Gly Phe Leu Asn Ala Ser Ile His Thr Gly Asp 145 150 155 160 Thr Phe Ser Leu Ser Phe Cys Lys Ser Asn Glu Val His His Phe Phe 165 170 175 Cys Asp Ile Pro Ala Val Met Val Leu Ser Cys Ser Asp Arg His Ile 180 185 190 Ser Glu Leu Val Leu Ile Tyr Val Val Ser Phe Asn Ile Phe Ile Ala 195 200 205 Leu Leu Val Ile Leu Ile Ser Tyr Thr Phe Ile Phe Ile Thr Ile Leu 210 215 220 Lys Met His Ser Ala Ser Val Tyr Gln Lys Pro Leu Ser Thr Cys Ala 225 230 235 240 Ser His Phe Ile Ala Val Gly Ile Phe Tyr Gly Thr Ile Ile Phe Met 245 250 255 Tyr Leu Gln Pro Ser Ser Ser His Ser Met Asp Thr Asp Lys Met Ala 260 265 270 Pro Val Phe Tyr Thr Met Val Ile Pro Met Leu Asn Pro Leu Val Tyr 275 280 285 Ser Leu Arg Asn Lys Glu Val Lys Ser Ala Phe Lys Lys Val Val Glu 290 295 300 Lys Ala Lys Leu Ser Val Gly Trp Ser Val 305 310 <210> 441 <211> 945 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(945) <400> 441 atg gag aac aac aca gag gtg act gaa ttc atc ctt gtg ggg tta act 48 Met Glu Asn Asn Thr Glu Val Thr Glu Phe Ile Leu Val Gly Leu Thr 1 5 10 15 gat gac cca gaa ctg cag atc cca ctc ttc ata gtc ttc ctt ttc atc 96 Asp Asp Pro Glu Leu Gln Ile Pro Leu Phe Ile Val Phe Leu Phe Ile 20 25 30 tac ctc atc act ctg gtt ggg aac ctg ggg atg att gaa ttg att cta 144 Tyr Leu Ile Thr Leu Val Gly Asn Leu Gly Met Ile Glu Leu Ile Leu 35 40 45 ctg gac tcc tgt ctc cac acc ccc atg tac ttc ttc ctc agt aac ctc 192 Leu Asp Ser Cys Leu His Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu 50 55 60 tcc ctg gtg gac ttt ggt tat tcc tca gct gtc act ccc aag gtg atg 240 Ser Leu Val Asp Phe Gly Tyr Ser Ser Ala Val Thr Pro Lys Val Met 65 70 75 80 gtg ggg ttt ctc aca gga gac aaa ttc ata tta tat aat gct tgt gcc 288 Val Gly Phe Leu Thr Gly Asp Lys Phe Ile Leu Tyr Asn Ala Cys Ala 85 90 95 aca caa ttc ttc ttc ttt gta gcc ttt atc act gca gaa agt ttc ctc 336 Thr Gln Phe Phe Phe Phe Val Ala Phe Ile Thr Ala Glu Ser Phe Leu 100 105 110 ctg gca tca atg gcc tat gac cgc tat gca gca ttg tgt aaa ccc ctg 384 Leu Ala Ser Met Ala Tyr Asp Arg Tyr Ala Ala Leu Cys Lys Pro Leu 115 120 125 cat tac acc acc acc atg aca aca aat gta tgt gct tgc ctg gcc ata 432 His Tyr Thr Thr Thr Met Thr Thr Asn Val Cys Ala Cys Leu Ala Ile 130 135 140 ggc tcc tac atc tgt ggt ttc ctg aat gca tcc att cat act ggg aac 480 Gly Ser Tyr Ile Cys Gly Phe Leu Asn Ala Ser Ile His Thr Gly Asn 145 150 155 160 act ttc agg ctc tcc ttc tgt aga tcc aat gta gtt gaa cac ttt ttc 528 Thr Phe Arg Leu Ser Phe Cys Arg Ser Asn Val Val Glu His Phe Phe 165 170 175 tgt gat gct cct cct ctc ttg act ctc tca tgt tca gac aac tac atc 576 Cys Asp Ala Pro Pro Leu Leu Thr Leu Ser Cys Ser Asp Asn Tyr Ile 180 185 190 agt gag atg gtt att ttt ttt gtg gtg gga ttc aat gac ctc ttt tct 624 Ser Glu Met Val Ile Phe Phe Val Val Gly Phe Asn Asp Leu Phe Ser 195 200 205 atc ctg gta atc ttg atc tcc tac tta ttt ata ttt atc acc atc atg 672 Ile Leu Val Ile Leu Ile Ser Tyr Leu Phe Ile Phe Ile Thr Ile Met 210 215 220 aag atg cgc tca cct gaa gga cgc cag aag gcc ttt tct act tgt gct 720 Lys Met Arg Ser Pro Glu Gly Arg Gln Lys Ala Phe Ser Thr Cys Ala 225 230 235 240 tcc cac ctt act gca gtt tcc atc ttt tat ggg aca gga atc ttt atg 768 Ser His Leu Thr Ala Val Ser Ile Phe Tyr Gly Thr Gly Ile Phe Met 245 250 255 tac tta cga cct aac tcc agc cat ttc atg ggc aca gac aaa atg gca 816 Tyr Leu Arg Pro Asn Ser Ser His Phe Met Gly Thr Asp Lys Met Ala 260 265 270 tct gtg ttc tat gcc ata gtc att ccc atg ttg aat cca ctg gtc tac 864 Ser Val Phe Tyr Ala Ile Val Ile Pro Met Leu Asn Pro Leu Val Tyr 275 280 285 agc ctg agg aac aaa gag gtt aag agt gcc ttt aaa aag act gta ggg 912 Ser Leu Arg Asn Lys Glu Val Lys Ser Ala Phe Lys Lys Thr Val Gly 290 295 300 aag gca aag gcc tct ata gga ttc ata ttt taa 945 Lys Ala Lys Ala Ser Ile Gly Phe Ile Phe 305 310 315 <210> 442 <211> 314 <212> PRT <213> Homo sapiens <400> 442 Met Glu Asn Asn Thr Glu Val Thr Glu Phe Ile Leu Val Gly Leu Thr 1 5 10 15 Asp Asp Pro Glu Leu Gln Ile Pro Leu Phe Ile Val Phe Leu Phe Ile 20 25 30 Tyr Leu Ile Thr Leu Val Gly Asn Leu Gly Met Ile Glu Leu Ile Leu 35 40 45 Leu Asp Ser Cys Leu His Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu 50 55 60 Ser Leu Val Asp Phe Gly Tyr Ser Ser Ala Val Thr Pro Lys Val Met 65 70 75 80 Val Gly Phe Leu Thr Gly Asp Lys Phe Ile Leu Tyr Asn Ala Cys Ala 85 90 95 Thr Gln Phe Phe Phe Phe Val Ala Phe Ile Thr Ala Glu Ser Phe Leu 100 105 110 Leu Ala Ser Met Ala Tyr Asp Arg Tyr Ala Ala Leu Cys Lys Pro Leu 115 120 125 His Tyr Thr Thr Thr Met Thr Thr Asn Val Cys Ala Cys Leu Ala Ile 130 135 140 Gly Ser Tyr Ile Cys Gly Phe Leu Asn Ala Ser Ile His Thr Gly Asn 145 150 155 160 Thr Phe Arg Leu Ser Phe Cys Arg Ser Asn Val Val Glu His Phe Phe 165 170 175 Cys Asp Ala Pro Pro Leu Leu Thr Leu Ser Cys Ser Asp Asn Tyr Ile 180 185 190 Ser Glu Met Val Ile Phe Phe Val Val Gly Phe Asn Asp Leu Phe Ser 195 200 205 Ile Leu Val Ile Leu Ile Ser Tyr Leu Phe Ile Phe Ile Thr Ile Met 210 215 220 Lys Met Arg Ser Pro Glu Gly Arg Gln Lys Ala Phe Ser Thr Cys Ala 225 230 235 240 Ser His Leu Thr Ala Val Ser Ile Phe Tyr Gly Thr Gly Ile Phe Met 245 250 255 Tyr Leu Arg Pro Asn Ser Ser His Phe Met Gly Thr Asp Lys Met Ala 260 265 270 Ser Val Phe Tyr Ala Ile Val Ile Pro Met Leu Asn Pro Leu Val Tyr 275 280 285 Ser Leu Arg Asn Lys Glu Val Lys Ser Ala Phe Lys Lys Thr Val Gly 290 295 300 Lys Ala Lys Ala Ser Ile Gly Phe Ile Phe 305 310 <210> 443 <211> 777 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(777) <400> 443 atg tac ttt ttc ctt agt aat ctg tcg ttt ctg gac atc tgc tat gtt 48 Met Tyr Phe Phe Leu Ser Asn Leu Ser Phe Leu Asp Ile Cys Tyr Val 1 5 10 15 tcc act ata gcc ccc aag atg ctc tca gac ttc ttc aag aag cat aaa 96 Ser Thr Ile Ala Pro Lys Met Leu Ser Asp Phe Phe Lys Lys His Lys 20 25 30 ttc atc tcc ttt atg ggg tgc agt atg cag tac ttt ttc ttc tct agc 144 Phe Ile Ser Phe Met Gly Cys Ser Met Gln Tyr Phe Phe Phe Ser Ser 35 40 45 cta ggt cta act gag tgc tgt ctt ctg gca gcc atg gct tat gat cga 192 Leu Gly Leu Thr Glu Cys Cys Leu Leu Ala Ala Met Ala Tyr Asp Arg 50 55 60 tat gct gcc att tgc aac cct ctg ctc tac agg gcc atc atg ttt ccc 240 Tyr Ala Ala Ile Cys Asn Pro Leu Leu Tyr Arg Ala Ile Met Phe Pro 65 70 75 80 acc ctc tgc gtg cag atg gtg gca gga tct tgt ata act gga ttc tta 288 Thr Leu Cys Val Gln Met Val Ala Gly Ser Cys Ile Thr Gly Phe Leu 85 90 95 ggc tca ttt atc caa ctc tgt gcc ttg ctt cag ctc cat ttc tgt ggg 336 Gly Ser Phe Ile Gln Leu Cys Ala Leu Leu Gln Leu His Phe Cys Gly 100 105 110 cca aat gtc atc aac cat ttc ttc tgt gat ctg ccc cag ctg ctg att 384 Pro Asn Val Ile Asn His Phe Phe Cys Asp Leu Pro Gln Leu Leu Ile 115 120 125 cta tcc tgt tct gac acc ttt ttc ttt caa gtc atg acc tct gtt ctc 432 Leu Ser Cys Ser Asp Thr Phe Phe Phe Gln Val Met Thr Ser Val Leu 130 135 140 aca gtg atc ttt gga ctc acg tct gtc tta gtt atc atg ata tct tat 480 Thr Val Ile Phe Gly Leu Thr Ser Val Leu Val Ile Met Ile Ser Tyr 145 150 155 160 ggt tat atc att gcc acc att ctg aag atc acc tca gct gaa ggc aga 528 Gly Tyr Ile Ile Ala Thr Ile Leu Lys Ile Thr Ser Ala Glu Gly Arg 165 170 175 gcc aaa tct ttc aac act tgt gct tct cac ctt aca gca gtg atc ctt 576 Ala Lys Ser Phe Asn Thr Cys Ala Ser His Leu Thr Ala Val Ile Leu 180 185 190 ttc ttt ggc tca ggt atc ttt gtt tat atg tat cct aat gct ggt gat 624 Phe Phe Gly Ser Gly Ile Phe Val Tyr Met Tyr Pro Asn Ala Gly Asp 195 200 205 tcc ctg agc caa aac aag ttg gca tca gtc tta tac aca gtt aca atc 672 Ser Leu Ser Gln Asn Lys Leu Ala Ser Val Leu Tyr Thr Val Thr Ile 210 215 220 ccc atg tta aat cca gtg atc tac agc ctg agg aac aag gaa atc aaa 720 Pro Met Leu Asn Pro Val Ile Tyr Ser Leu Arg Asn Lys Glu Ile Lys 225 230 235 240 gat gct cta aac aga tgg aag aag aga atc ttc tcc tgg tgt tat gga 768 Asp Ala Leu Asn Arg Trp Lys Lys Arg Ile Phe Ser Trp Cys Tyr Gly 245 250 255 atg aaa taa 777 Met Lys <210> 444 <211> 258 <212> PRT <213> Homo sapiens <400> 444 Met Tyr Phe Phe Leu Ser Asn Leu Ser Phe Leu Asp Ile Cys Tyr Val 1 5 10 15 Ser Thr Ile Ala Pro Lys Met Leu Ser Asp Phe Phe Lys Lys His Lys 20 25 30 Phe Ile Ser Phe Met Gly Cys Ser Met Gln Tyr Phe Phe Phe Ser Ser 35 40 45 Leu Gly Leu Thr Glu Cys Cys Leu Leu Ala Ala Met Ala Tyr Asp Arg 50 55 60 Tyr Ala Ala Ile Cys Asn Pro Leu Leu Tyr Arg Ala Ile Met Phe Pro 65 70 75 80 Thr Leu Cys Val Gln Met Val Ala Gly Ser Cys Ile Thr Gly Phe Leu 85 90 95 Gly Ser Phe Ile Gln Leu Cys Ala Leu Leu Gln Leu His Phe Cys Gly 100 105 110 Pro Asn Val Ile Asn His Phe Phe Cys Asp Leu Pro Gln Leu Leu Ile 115 120 125 Leu Ser Cys Ser Asp Thr Phe Phe Phe Gln Val Met Thr Ser Val Leu 130 135 140 Thr Val Ile Phe Gly Leu Thr Ser Val Leu Val Ile Met Ile Ser Tyr 1 45 150 155 160 Gly Tyr Ile Ile Ala Thr Ile Leu Lys Ile Thr Ser Ala Glu Gly Arg 165 170 175 Ala Lys Ser Phe Asn Thr Cys Ala Ser His Leu Thr Ala Val Ile Leu 180 185 190 Phe Phe Gly Ser Gly Ile Phe Val Tyr Met Tyr Pro Asn Ala Gly Asp 195 200 205 Ser Leu Ser Gln Asn Lys Leu Ala Ser Val Leu Tyr Thr Val Thr Ile 210 215 220 Pro Met Leu Asn Pro Val Ile Tyr Ser Leu Arg Asn Lys Glu Ile Lys 225 230 235 240 Asp Ala Leu Asn Arg Trp Lys Lys Arg Ile Phe Ser Trp Cys Tyr Gly 245 250 255 Met Lys <210> 445 <211> 936 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(936) <400> 445 atg act ggg gga gga aat att aca gaa atc acc tat ttc atc ctg ctg 48 Met Thr Gly Gly Gly Asn Ile Thr Glu Ile Thr Tyr Phe Ile Leu Leu 1 5 10 15 gga ttc tca gat ttt ccc agg atc ata aaa gtg ctc ttc act ata ttc 96 Gly Phe Ser Asp Phe Pro Arg Ile Ile Lys Val Leu Phe Thr Ile Phe 20 25 30 ctg gtg atc tac att aca tct ctg gcc tgg aac ctc tcc ctc att gtt 144 Leu Val Ile Tyr Ile Thr Ser Leu Ala Trp Asn Leu Ser Leu Ile Val 35 40 45 tta ata agg atg gat tcc cac ctc cat aca ccc atg tat ttc ttc ctc 192 Leu Ile Arg Met Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu 50 55 60 agt aac ctg tcc ttc ata gat gtc tgc tat atc agc tcc aca gtc ccc 240 Ser Asn Leu Ser Phe Ile Asp Val Cys Tyr Ile Ser Ser Thr Val Pro 65 70 75 80 aag atg ctc tcc aac ctc tta cag gaa cag caa act atc act ttt gtt 288 Lys Met Leu Ser Asn Leu Leu Gln Glu Gln Gln Thr Ile Thr Phe Val 85 90 95 ggt tgt att att cag tac ttt atc ttt tca acg atg gga ctg agt gag 336 Gly Cys Ile Ile Gln Tyr Phe Ile Phe Ser Thr Met Gly Leu Ser Glu 100 105 110 tct tgt ctc atg aca gcc atg gct tat gat cgt tat gct gcc att tgt 384 Ser Cys Leu Met Thr Ala Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys 115 120 125 aac ccc ctg ctc tat tca tcc atc atg tca ccc acc ctc tgt gtt tgg 432 Asn Pro Leu Leu Tyr Ser Ser Ile Met Ser Pro Thr Leu Cys Val Trp 130 135 140 atg gta ctg gga gcc tac atg act ggc ctc act gct tct tta ttc caa 480 Met Val Leu Gly Ala Tyr Met Thr Gly Leu Thr Ala Ser Leu Phe Gln 145 150 155 160 att ggt gct ttg ctt caa ctc cac ttc tgt ggg tct aat gtc atc aga 528 Ile Gly Ala Leu Leu Gln Leu His Phe Cys Gly Ser Asn Val Ile Arg 165 170 175 cat ttc ttc tgt gac atg ccc caa ctg tta atc ttg tcc tgt act gac 576 His Phe Phe Cys Asp Met Pro Gln Leu Leu Ile Leu Ser Cys Thr Asp 180 185 190 act ttc ttt gta cag gtc atg act gct ata tta acc atg ttc ttt ggg 624 Thr Phe Phe Val Gln Val Met Thr Ala Ile Leu Thr Met Phe Phe Gly 195 200 205 ata gca agt gcc cta gtt atc atg ata tcc tat ggc tat att ggc atc 672 Ile Ala Ser Ala Leu Val Ile Met Ile Ser Tyr Gly Tyr Ile Gly Ile 210 215 220 tcc atc atg aag atc act tca gct aaa ggc agg tcc aag gca ttc aac 720 Ser Ile Met Lys Ile Thr Ser Ala Lys Gly Arg Ser Lys Ala Phe Asn 225 230 235 240 acc tgt gct tct cat cta aca gct gtt tcc ctc ttc tat aca tca gga 768 Thr Cys Ala Ser His Leu Thr Ala Val Ser Leu Phe Tyr Thr Ser Gly 245 250 255 atc ttt gtc tat ttg agt tcc agc tct gga ggt tct tca agc ttt gac 816 Ile Phe Val Tyr Leu Ser Ser Ser Ser Gly Gly Ser Ser Ser Phe Asp 260 265 270 aga ttt gca tct gtt ttc tac act gtg gtc att ccc atg tta aat ccc 864 Arg Phe Ala Ser Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro 275 280 285 ttg att tac agt ttg agg aac aaa gaa att aaa gat gcc tta aag agg 912 Leu Ile Tyr Ser Leu Arg Asn Lys Glu Ile Lys Asp Ala Leu Lys Arg 290 295 300 ttg caa aag aga aag tgc tgc tga 936 Leu Gln Lys Arg Lys Cys Cys 305 310 <210> 446 <211> 311 <212> PRT <213> Homo sapiens <400> 446 Met Thr Gly Gly Gly Asn Ile Thr Glu Ile Thr Tyr Phe Ile Leu Leu 1 5 10 15 Gly Phe Ser Asp Phe Pro Arg Ile Ile Lys Val Leu Phe Thr Ile Phe 20 25 30 Leu Val Ile Tyr Ile Thr Ser Leu Ala Trp Asn Leu Ser Leu Ile Val 35 40 45 Leu Ile Arg Met Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu 50 55 60 Ser Asn Leu Ser Phe Ile Asp Val Cys Tyr Ile Ser Ser Thr Val Pro 65 70 75 80 Lys Met Leu Ser Asn Leu Leu Gln Glu Gln Gln Thr Ile Thr Phe Val 85 90 95 Gly Cys Ile Ile Gln Tyr Phe Ile Phe Ser Thr Met Gly Leu Ser Glu 100 105 110 Ser Cys Leu Met Thr Ala Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys 115 120 125 Asn Pro Leu Leu Tyr Ser Ser Ile Met Ser Pro Thr Leu Cys Val Trp 130 135 140 Met Val Leu Gly Ala Tyr Met Thr Gly Leu Thr Ala Ser Leu Phe Gln 145 150 155 160 Ile Gly Ala Leu Leu Gln Leu His Phe Cys Gly Ser Asn Val Ile Arg 165 170 175 His Phe Phe Cys Asp Met Pro Gln Leu Leu Ile Leu Ser Cys Thr Asp 180 185 190 Thr Phe Phe Val Gln Val Met Thr Ala Ile Leu Thr Met Phe Phe Gly 195 200 205 Ile Ala Ser Ala Leu Val Ile Met Ile Ser Tyr Gly Tyr Ile Gly Ile 210 215 220 Ser Ile Met Lys Ile Thr Ser Ala Lys Gly Arg Ser Lys Ala Phe Asn 225 230 235 240 Thr Cys Ala Ser His Leu Thr Ala Val Ser Leu Phe Tyr Thr Ser Gly 245 250 255 Ile Phe Val Tyr Leu Ser Ser Ser Ser Gly Gly Ser Ser Ser Phe Asp 260 265 270 Arg Phe Ala Ser Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro 275 280 285 Leu Ile Tyr Ser Leu Arg Asn Lys Glu Ile Lys Asp Ala Leu Lys Arg 290 295 300 Leu Gln Lys Arg Lys Cys Cys 305 310 <210> 447 <211> 1059 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1059) <400> 447 atg aca tct cag gaa agg gat aca gct att tat tcc att aat gtc agt 48 Met Thr Ser Gln Glu Arg Asp Thr Ala Ile Tyr Ser Ile Asn Val Ser 1 5 10 15 ttt gtt gca aag ggg atg act agc cgc tct gtg tgt gag aag atg acc 96 Phe Val Ala Lys Gly Met Thr Ser Arg Ser Val Cys Glu Lys Met Thr 20 25 30 atg aca acg gag aac ccc aac cag act gtg gtg agc cac ttc ttc ctg 144 Met Thr Thr Glu Asn Pro Asn Gln Thr Val Val Ser His Phe Phe Leu 35 40 45 gag ggt ttg agg tac acc gct aaa cat tct agc ctc ttc ttc ctc ctc 192 Glu Gly Leu Arg Tyr Thr Ala Lys His Ser Ser Leu Phe Phe Leu Leu 50 55 60 ttc ctc ctc atc tac agc atc act gtg gct ggg aat ctc ctc atc ctc 240 Phe Leu Leu Ile Tyr Ser Ile Thr Val Ala Gly Asn Leu Leu Ile Leu 65 70 75 80 cta act gtg ggc tct gac tct cac ctc agc tta ccc atg tac cac ttc 288 Leu Thr Val Gly Ser Asp Ser His Leu Ser Leu Pro Met Tyr His Phe 85 90 95 ctg ggg cac ctc tcc ttc ctg gat gcc tgt ttg tct aca gtg aca gtg 336 Leu Gly His Leu Ser Phe Leu Asp Ala Cys Leu Ser Thr Val Thr Val 100 105 110 ccc aag gtc atg gca ggc ctg ctg act ctg gat ggg aag gtg atc tcc 384 Pro Lys Val Met Ala Gly Leu Leu Thr Leu Asp Gly Lys Val Ile Ser 115 120 125 ttt gag ggc tgt gcc gta cag ctt tat tgc ttc cac ttt ctg gcc agc 432 Phe Glu Gly Cys Ala Val Gln Leu Tyr Cys Phe His Phe Leu Ala Ser 130 135 140 act gag tgc ttc ctg tac aca gtc atg gcc tat gac cgc tat ctg gct 480 Thr Glu Cys Phe Leu Tyr Thr Val Met Ala Tyr Asp Arg Tyr Leu Ala 145 150 155 160 atc tgt caa ccc ctg cac tac cca gtg gcc atg aac aga agg atg tgt 528 Ile Cys Gln Pro Leu His Tyr Pro Val Ala Met Asn Arg Arg Met Cys 165 170 175 gca gaa atg gct gga atc acc tgg gcc ata ggt gcc acg cac gct gca 576 Ala Glu Met Ala Gly Ile Thr Trp Ala Ile Gly Ala Thr His Ala Ala 180 185 190 atc cac acc tcc ctc acc ttc cgc ctg ctc tac tgt ggg cct tgc cac 624 Ile His Thr Ser Leu Thr Phe Arg Leu Leu Tyr Cys Gly Pro Cys His 195 200 205 att gcc tac ttc ttc tgc gac ata ccc cct gtc cta aag ctc gcc tgt 672 Ile Ala Tyr Phe Phe Cys Asp Ile Pro Pro Val Leu Lys Leu Ala Cys 210 215 220 aca gac acc acc att aat gag cta gtc atg ctt gcc agc att ggc atc 720 Thr Asp Thr Thr Ile Asn Glu Leu Val Met Leu Ala Ser Ile Gly Ile 225 230 235 240 gtg gct gca ggc tgc ctc atc ctc atc gtt att tcc tac atc ttc atc 768 Val Ala Ala Gly Cys Leu Ile Leu Ile Val Ile Ser Tyr Ile Phe Ile 245 250 255 gtg gca gct gtg ttg cgc atc cgc aca gcc cag ggc cgg cag cgg gcc 816 Val Ala Ala Val Leu Arg Ile Arg Thr Ala Gln Gly Arg Gln Arg Ala 260 265 270 ttc tcc ccc tgc act gcc cag ctc act ggg gtg ctc ctg tac tac gtg 864 Phe Ser Pro Cys Thr Ala Gln Leu Thr Gly Val Leu Leu Tyr Tyr Val 275 280 285 cca cct gtc tgt atc tac ctg cag cct cgc tcc agt gag gca gga gct 912 Pro Pro Val Cys Ile Tyr Leu Gln Pro Arg Ser Ser Glu Ala Gly Ala 290 295 300 ggg gcc cct gct gtc ttc tac aca atc gta act cca atg ctc aac cca 960 Gly Ala Pro Ala Val Phe Tyr Thr Ile Val Thr Pro Met Leu Asn Pro 305 310 315 320 ttc att tac act ttg cgg aac aag gag gtg aag cat gct ctg caa agg 1008 Phe Ile Tyr Thr Leu Arg Asn Lys Glu Val Lys His Ala Leu Gln Arg 325 330 335 ctt ttg tgc agc agc ttc cga gag tct aca gca ggc agc cca ccc cca 1056 Leu Leu Cys Ser Ser Phe Arg Glu Ser Thr Ala Gly Ser Pro Pro Pro 340 345 350 tag 1059 <210> 448 <211> 352 <212> PRT <213> Homo sapiens <400> 448 Met Thr Ser Gln Glu Arg Asp Thr Ala Ile Tyr Ser Ile Asn Val Ser 1 5 10 15 Phe Val Ala Lys Gly Met Thr Ser Arg Ser Val Cys Glu Lys Met Thr 20 25 30 Met Thr Thr Glu Asn Pro Asn Gln Thr Val Val Ser His Phe Phe Leu 35 40 45 Glu Gly Leu Arg Tyr Thr Ala Lys His Ser Ser Leu Phe Phe Leu Leu 50 55 60 Phe Leu Leu Ile Tyr Ser Ile Thr Val Ala Gly Asn Leu Leu Ile Leu 65 70 75 80 Leu Thr Val Gly Ser Asp Ser His Leu Ser Leu Pro Met Tyr His Phe 85 90 95 Leu Gly His Leu Ser Phe Leu Asp Ala Cys Leu Ser Thr Val Thr Val 100 105 110 Pro Lys Val Met Ala Gly Leu Leu Thr Leu Asp Gly Lys Val Ile Ser 115 120 125 Phe Glu Gly Cys Ala Val Gln Leu Tyr Cys Phe His Phe Leu Ala Ser 130 135 140 Thr Glu Cys Phe Leu Tyr Thr Val Met Ala Tyr Asp Arg Tyr Leu Ala 145 150 155 160 Ile Cys Gln Pro Leu His Tyr Pro Val Ala Met Asn Arg Arg Met Cys 165 170 175 Ala Glu Met Ala Gly Ile Thr Trp Ala Ile Gly Ala Thr His Ala Ala 180 185 190 Ile His Thr Ser Leu Thr Phe Arg Leu Leu Tyr Cys Gly Pro Cys His 195 200 205 Ile Ala Tyr Phe Phe Cys Asp Ile Pro Pro Val Leu Lys Leu Ala Cys 210 215 220 Thr Asp Thr Thr Ile Asn Glu Leu Val Met Leu Ala Ser Ile Gly Ile 225 230 235 240 Val Ala Ala Gly Cys Leu Ile Leu Ile Val Ile Ser Tyr Ile Phe Ile 245 250 255 Val Ala Ala Val Leu Arg Ile Arg Thr Ala Gln Gly Arg Gln Arg Ala 260 265 270 Phe Ser Pro Cys Thr Ala Gln Leu Thr Gly Val Leu Leu Tyr Tyr Val 275 280 285 Pro Pro Val Cys Ile Tyr Leu Gln Pro Arg Ser Ser Glu Ala Gly Ala 290 295 300 Gly Ala Pro Ala Val Phe Tyr Thr Ile Val Thr Pro Met Leu Asn Pro 305 310 315 320 Phe Ile Tyr Thr Leu Arg Asn Lys Glu Val Lys His Ala Leu Gln Arg 325 330 335 Leu Leu Cys Ser Ser Phe Arg Glu Ser Thr Ala Gly Ser Pro Pro Pro 340 345 350 <210> 449 <211> 972 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(972) <400> 449 atg aac cct gaa aac tgg act cag gta aca agc ttt gtc ctt ctg ggt 48 Met Asn Pro Glu Asn Trp Thr Gln Val Thr Ser Phe Val Leu Leu Gly 1 5 10 15 ttc ccc agt agc cac ctc ata cag ttc ctg gtg ttc ctg ggg tta atg 96 Phe Pro Ser Ser His Leu Ile Gln Phe Leu Val Phe Leu Gly Leu Met 20 25 30 gtg acc tac att gta aca gcc aca ggc aag ctg cta att att gtg ctc 144 Val Thr Tyr Ile Val Thr Ala Thr Gly Lys Leu Leu Ile Ile Val Leu 35 40 45 agc tgg ata gac caa cgc ctg cac ata cag atg tac ttc ttc ctg cgg 192 Ser Trp Ile Asp Gln Arg Leu His Ile Gln Met Tyr Phe Phe Leu Arg 50 55 60 aat ttc tcc ttc ctg gag ctg ttg ctg gta act gtt gtg gtt ccc aag 240 Asn Phe Ser Phe Leu Glu Leu Leu Leu Val Thr Val Val Val Pro Lys 65 70 75 80 atg ctt gtc gtc atc ctc acg ggg gat cac acc atc tca ttt gtc agc 288 Met Leu Val Val Ile Leu Thr Gly Asp His Thr Ile Ser Phe Val Ser 85 90 95 tgc atc atc cag tcc tac ctc tac ttc ttt cta ggc acc act gac ttc 336 Cys Ile Ile Gln Ser Tyr Leu Tyr Phe Phe Leu Gly Thr Thr Asp Phe 100 105 110 ttc ctc ttg gcc gtc atg tct ctg gat cgt tac ctg gca atc tgc cga 384 Phe Leu Leu Ala Val Met Ser Leu Asp Arg Tyr Leu Ala Ile Cys Arg 115 120 125 cca ctc cgc tat gag acc ctg atg aat ggc cat gtc tgt tcc caa cta 432 Pro Leu Arg Tyr Glu Thr Leu Met Asn Gly His Val Cys Ser Gln Leu 130 135 140 gtg ctg gcc tcc tgg cta gct gga ttc ctc tgg gtc ctt tgc ccc act 480 Val Leu Ala Ser Trp Leu Ala Gly Phe Leu Trp Val Leu Cys Pro Thr 145 150 155 160 gtc ctc atg gcc agc ctg cct ttc tgt ggc ccc aat ggt att gac cac 528 Val Leu Met Ala Ser Leu Pro Phe Cys Gly Pro Asn Gly Ile Asp His 165 170 175 ttc ttt cgt gac agt tgg ccc ttg ctc agg ctt tct tgt ggg gac acc 576 Phe Phe Arg Asp Ser Trp Pro Leu Leu Arg Leu Ser Cys Gly Asp Thr 180 185 190 cac ctg ctg aaa ctg gtg gct ttc atg ctc tct acg ttg gtg tta ctg 624 His Leu Leu Lys Leu Val Ala Phe Met Leu Ser Thr Leu Val Leu Leu 195 200 205 ggc tca ctg gct ctg acc tca gtt tcc tat gcc tgc att ctt gcc act 672 Gly Ser Leu Ala Leu Thr Ser Val Ser Tyr Ala Cys Ile Leu Ala Thr 210 215 220 gtt ctc agg gcc cct aca gct gct gag cga agg aaa gcg ttt tcc act 720 Val Leu Arg Ala Pro Thr Ala Ala Glu Arg Arg Lys Ala Phe Ser Thr 225 230 235 240 tgc gcc tcg cat ctt aca gtg gtg gtc atc atc tat ggc agt tcc atc 768 Cys Ala Ser His Leu Thr Val Val Val Ile Ile Tyr Gly Ser Ser Ile 245 250 255 ttt ctc tac att cgt atg tca gag gct cag tcc aaa ctg ctc aac aaa 816 Phe Leu Tyr Ile Arg Met Ser Glu Ala Gln Ser Lys Leu Leu Asn Lys 260 265 270 ggt gcc tcc gtc ctg agc tgc atc atc aca ccc ctc ttg aac cca ttc 864 Gly Ala Ser Val Leu Ser Cys Ile Ile Thr Pro Leu Leu Asn Pro Phe 275 280 285 atc ttc act ctc cgc aat gac aag gtg cag caa gca ctg aga gaa gcc 912 Ile Phe Thr Leu Arg Asn Asp Lys Val Gln Gln Ala Leu Arg Glu Ala 290 295 300 ttg ggg tgg ccc agg ctc act gct gtg atg aaa ctg agg gtc aca agt 960 Leu Gly Trp Pro Arg Leu Thr Ala Val Met Lys Leu Arg Val Thr Ser 305 310 315 320 caa agg aaa tga 972 Gln Arg Lys <210> 450 <211> 323 <212> PRT <213> Homo sapiens <400> 450 Met Asn Pro Glu Asn Trp Thr Gln Val Thr Ser Phe Val Leu Leu Gly 1 5 10 15 Phe Pro Ser Ser His Leu Ile Gln Phe Leu Val Phe Leu Gly Leu Met 20 25 30 Val Thr Tyr Ile Val Thr Ala Thr Gly Lys Leu Leu Ile Ile Val Leu 35 40 45 Ser Trp Ile Asp Gln Arg Leu His Ile Gln Met Tyr Phe Phe Leu Arg 50 55 60 Asn Phe Ser Phe Leu Glu Leu Leu Leu Val Thr Val Val Val Pro Lys 65 70 75 80 Met Leu Val Val Ile Leu Thr Gly Asp His Thr Ile Ser Phe Val Ser 85 90 95 Cys Ile Ile Gln Ser Tyr Leu Tyr Phe Phe Leu Gly Thr Thr Asp Phe 100 105 110 Phe Leu Leu Ala Val Met Ser Leu Asp Arg Tyr Leu Ala Ile Cys Arg 115 120 125 Pro Leu Arg Tyr Glu Thr Leu Met Asn Gly His Val Cys Ser Gln Leu 130 135 140 Val Leu Ala Ser Trp Leu Ala Gly Phe Leu Trp Val Leu Cys Pro Thr 145 150 155 160 Val Leu Met Ala Ser Leu Pro Phe Cys Gly Pro Asn Gly Ile Asp His 165 170 175 Phe Phe Arg Asp Ser Trp Pro Leu Leu Arg Leu Ser Cys Gly Asp Thr 180 185 190 His Leu Leu Lys Leu Val Ala Phe Met Leu Ser Thr Leu Val Leu Leu 195 200 205 Gly Ser Leu Ala Leu Thr Ser Val Ser Tyr Ala Cys Ile Leu Ala Thr 210 215 220 Val Leu Arg Ala Pro Thr Ala Ala Glu Arg Arg Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Thr Val Val Val Ile Ile Tyr Gly Ser Ser Ile 245 250 255 Phe Leu Tyr Ile Arg Met Ser Glu Ala Gln Ser Lys Leu Leu Asn Lys 260 265 270 Gly Ala Ser Val Leu Ser Cys Ile Ile Thr Pro Leu Leu Asn Pro Phe 275 280 285 Ile Phe Thr Leu Arg Asn Asp Lys Val Gln Gln Ala Leu Arg Glu Ala 290 295 300 Leu Gly Trp Pro Arg Leu Thr Ala Val Met Lys Leu Arg Val Thr Ser 305 310 315 320 Gln Arg Lys <210> 451 <211> 945 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(945) <400> 451 atg ggt gta aaa aac cat tcc aca gtg act gag ttt ctt ctt tca gga 48 Met Gly Val Lys Asn His Ser Thr Val Thr Glu Phe Leu Leu Ser Gly 1 5 10 15 tta act gaa caa gca gag ctt cag ctg ccc ctc ttc tgc ctc ttc tta 96 Leu Thr Glu Gln Ala Glu Leu Gln Leu Pro Leu Phe Cys Leu Phe Leu 20 25 30 gga att tac aca gtt act gtg gtg gga aac ctc agc atg atc tca att 144 Gly Ile Tyr Thr Val Thr Val Val Gly Asn Leu Ser Met Ile Ser Ile 35 40 45 att agg ctg aat cgt caa ctt cat acc ccc atg tac tat ttc ctg agt 192 Ile Arg Leu Asn Arg Gln Leu His Thr Pro Met Tyr Tyr Phe Leu Ser 50 55 60 agt ttg tct ttt tta gat ttc tgc tat tct tct gtc att acc cct aaa 240 Ser Leu Ser Phe Leu Asp Phe Cys Tyr Ser Ser Val Ile Thr Pro Lys 65 70 75 80 atg cta tca ggg ttt tta tgc aga gat aga tcc atc tcc tat tct gga 288 Met Leu Ser Gly Phe Leu Cys Arg Asp Arg Ser Ile Ser Tyr Ser Gly 85 90 95 tgc atg att cag ctg ttt ttt ttc tgt gtt tgt gtt att tct gaa tgc 336 Cys Met Ile Gln Leu Phe Phe Phe Cys Val Cys Val Ile Ser Glu Cys 100 105 110 tac atg ctg gca gcc atg gcc tgc gat cgc tac gtg gcc atc tgc agc 384 Tyr Met Leu Ala Ala Met Ala Cys Asp Arg Tyr Val Ala Ile Cys Ser 115 120 125 cca ctg ctc tac agg gtc atc atg tcc cct agg gtc tgt tct ctg ctg 432 Pro Leu Leu Tyr Arg Val Ile Met Ser Pro Arg Val Cys Ser Leu Leu 130 135 140 gtg gct gct gtc ttc tca gta ggt ttc act gat gct gtg atc cat gga 480 Val Ala Ala Val Phe Ser Val Gly Phe Thr Asp Ala Val Ile His Gly 145 150 155 160 ggt tgt ata ctc agg ttg tct ttc tgt gga tca aac atc att aaa cat 528 Gly Cys Ile Leu Arg Leu Ser Phe Cys Gly Ser Asn Ile Ile Lys His 165 170 175 tat ttc tgt gac att gtc cct ctt att aaa ctc tcc tgc tcc agc act 576 Tyr Phe Cys Asp Ile Val Pro Leu Ile Lys Leu Ser Cys Ser Ser Thr 180 185 190 tat att gat gag ctt ttg att ttt gtc att ggt gga ttt aac atg gtg 624 Tyr Ile Asp Glu Leu Leu Ile Phe Val Ile Gly Gly Phe Asn Met Val 195 200 205 gcc aca agc cta aca atc att att tca tat gct ttt atc ctc acc agc 672 Ala Thr Ser Leu Thr Ile Ile Ile Ser Tyr Ala Phe Ile Leu Thr Ser 210 215 220 atc ctg cgc atc cac tct aaa aag ggc agg tgc aaa gcg ttt agc acc 720 Ile Leu Arg Ile His Ser Lys Lys Gly Arg Cys Lys Ala Phe Ser Thr 225 230 235 240 tgt agc tcc cac ctg aca gct gtt ctt atg ttt tat ggg tct ctg atg 768 Cys Ser Ser His Leu Thr Ala Val Leu Met Phe Tyr Gly Ser Leu Met 245 250 255 tcc atg tat ctc aaa cct gct tct agc agt tca ctc acc cag gag aaa 816 Ser Met Tyr Leu Lys Pro Ala Ser Ser Ser Ser Leu Thr Gln Glu Lys 260 265 270 gta tcc tca gta ttt tat acc act gtg att ctc atg ttg aat ccc ttg 864 Val Ser Ser Val Phe Tyr Thr Thr Val Ile Leu Met Leu Asn Pro Leu 275 280 285 ata tat agt ctg agg aac aat gaa gta aga aat gct ctg atg aaa ctt 912 I le Tyr Ser Leu Arg Asn Asn Glu Val Arg Asn Ala Leu Met Lys Leu 290 295 300 tta aga aga aaa ata tct tta tct cca gga taa 945 Leu Arg Arg Lys Ile Ser Leu Ser Pro Gly 305 310 315 <210> 452 <211> 314 <212> PRT <213> Homo sapiens <400> 452 Met Gly Val Lys Asn His Ser Thr Val Thr Glu Phe Leu Leu Ser Gly 1 5 10 15 Leu Thr Glu Gln Ala Glu Leu Gln Leu Pro Leu Phe Cys Leu Phe Leu 20 25 30 Gly Ile Tyr Thr Val Thr Val Val Gly Asn Leu Ser Met Ile Ser Ile 35 40 45 Ile Arg Leu Asn Arg Gln Leu His Thr Pro Met Tyr Tyr Phe Leu Ser 50 55 60 Ser Leu Ser Phe Leu Asp Phe Cys Tyr Ser Ser Val Ile Thr Pro Lys 65 70 75 80 Met Leu Ser Gly Phe Leu Cys Arg Asp Arg Ser Ile Ser Tyr Ser Gly 85 90 95 Cys Met Ile Gln Leu Phe Phe Phe Cys Val Cys Val Ile Ser Glu Cys 100 105 110 Tyr Met Leu Ala Ala Met Ala Cys Asp Arg Tyr Val Ala Ile Cys Ser 115 120 125 Pro Leu Leu Tyr Arg Val Ile Met Ser Pro Arg Val Cys Ser Leu Leu 130 135 140 Val Ala Ala Val Phe Ser Val Gly Phe Thr Asp Ala Val Ile His Gly 145 150 155 160 Gly Cys Ile Leu Arg Leu Ser Phe Cys Gly Ser Asn Ile Ile Lys His 165 170 175 Tyr Phe Cys Asp Ile Val Pro Leu Ile Lys Leu Ser Cys Ser Ser Thr 180 185 190 Tyr Ile Asp Glu Leu Leu Ile Phe Val Ile Gly Gly Phe Asn Met Val 195 200 205 Ala Thr Ser Leu Thr Ile Ile Ile Ser Tyr Ala Phe Ile Leu Thr Ser 210 215 220 Ile Leu Arg Ile His Ser Lys Lys Gly Arg Cys Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Leu Thr Ala Val Leu Met Phe Tyr Gly Ser Leu Met 245 250 255 Ser Met Tyr Leu Lys Pro Ala Ser Ser Ser Ser Leu Thr Gln Glu Lys 260 265 270 Val Ser Ser Val Phe Tyr Thr Thr Val Ile Leu Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Asn Glu Val Arg Asn Ala Leu Met Lys Leu 290 295 300 Leu Arg Arg Lys Ile Ser Leu Ser Pro Gly 305 310 <210> 453 <211> 849 <212> DNA <213> Homo sapiens <220> <221> CDS <22 2> (1)..(849) <400> 453 atg act gta gtg gga aac ctt ctt att gtg gtc ata gtg acc tcc gac 48 Met Thr Val Val Gly Asn Leu Leu Ile Val Val Ile Val Thr Ser Asp 1 5 10 15 cca cac ctg cac aca acc atg tat ttt ctc ttg ggc aat ctt tct ttc 96 Pro His Leu His Thr Thr Met Tyr Phe Leu Leu Gly Asn Leu Ser Phe 20 25 30 ctg gac ttt tgc tac tct tcc atc aca gca cct agg atg ctg gtt gac 144 Leu Asp Phe Cys Tyr Ser Ser Ile Thr Ala Pro Arg Met Leu Val Asp 35 40 45 ttg ctc tca ggc aac cct acc att tcc ttt ggt gga tgc ctg act caa 192 Leu Leu Ser Gly Asn Pro Thr Ile Ser Phe Gly Gly Cys Leu Thr Gln 50 55 60 ctc ttc ttc ttc cac ttc att gga ggc atc aag atc ttc ctg ctg act 240 Leu Phe Phe Phe His Phe Ile Gly Gly Ile Lys Ile Phe Leu Leu Thr 65 70 75 80 gtc atg gcg tat gac cgc tac att gcc att tcc cag ccc ctg cac tac 288 Val Met Ala Tyr Asp Arg Tyr Ile Ala Ile Ser Gln Pro Leu His Tyr 85 90 95 acg ctc att atg aat cag act gtc tgt gca ctc ctt atg gca gcc tcc 336 Thr Leu Ile Met Asn Gln Thr Val Cys Ala Leu Leu Met Ala Ala Ser 100 105 110 tgg gtg ggg ggc ttc atc cac tcc ata gta cag att gca ttg act atc 384 Trp Val Gly Gly Phe Ile His Ser Ile Val Gln Ile Ala Leu Thr Ile 115 120 125 cag ctg cca ttc tgt ggg cct gac aag ctg gac aac ttt tat tgt gat 432 Gln Leu Pro Phe Cys Gly Pro Asp Lys Leu Asp Asn Phe Tyr Cys Asp 130 135 140 gtg cct cag ctg atc aaa ttg gcc tgc aca gat acc ttt gtc tta gag 480 Val Pro Gln Leu Ile Lys Leu Ala Cys Thr Asp Thr Phe Val Leu Glu 145 150 155 160 ctt tta atg gtg tct aac aat ggc ctg gtg acc ctg atg tgt ttt ctg 528 Leu Leu Met Val Ser Asn Asn Gly Leu Val Thr Leu Met Cys Phe Leu 165 170 175 gtg ctt ctg gga tcg tac aca gca ctg cta gtc atg ctc cga agc cac 576 Val Leu Leu Gly Ser Tyr Thr Ala Leu Leu Val Met Leu Arg Ser His 180 185 190 tca cgg gag ggc cgc agc aag gcc ctg tct acc tgt gcc tct cac att 624 Ser Arg Glu Gly Arg Ser Lys Ala Leu Ser Thr Cys Ala Ser His Ile 195 200 205 gct gtg gtg acc tta atc ttt gtg cct tgc atc tac gtc tat aca agg 672 Ala Val Val Thr Leu Ile Phe Val Pro Cys Ile Tyr Val Tyr Thr Arg 210 215 220 cct ttt cgg aca ttc ccc atg gac aag gcc gtc tct gtg cta tac aca 720 Pro Phe Arg Thr Phe Pro Met Asp Lys Ala Val Ser Val Leu Tyr Thr 225 230 235 240 att gtc acc ccc atg ctg aat cct gcc atc tat acc ctg aga aac aag 768 Ile Val Thr Pro Met Leu Asn Pro Ala Ile Tyr Thr Leu Arg Asn Lys 245 250 255 gaa gtg atc atg gcc atg aag aag ctg tgg agg agg aaa aag gac cct 816 Glu Val Ile Met Ala Met Lys Lys Leu Trp Arg Arg Lys Lys Asp Pro 260 265 270 att ggt ccc ctg gag cac aga ccc tta cat tag 849 Ile Gly Pro Leu Glu His Arg Pro Leu His 275 280 <210> 454 <211> 282 <212> PRT <213> Homo sapiens <400> 454 Met Thr Val Val Gly Asn Leu Leu Ile Val Val Ile Val Thr Ser Asp 1 5 10 15 Pro His Leu His Thr Thr Met Tyr Phe Leu Leu Gly Asn Leu Ser Phe 20 25 30 Leu Asp Phe Cys Tyr Ser Ser Ile Thr Ala Pro Arg Met Leu Val Asp 35 40 45 Leu Leu Ser Gly Asn Pro Thr Ile Ser Phe Gly Gly Cys Leu Thr Gln 50 55 60 Leu Phe Phe Phe His Phe Ile Gly Gly Ile Lys Ile Phe Leu Leu Thr 65 70 75 80 Va l Met Ala Tyr Asp Arg Tyr Ile Ala Ile Ser Gln Pro Leu His Tyr 85 90 95 Thr Leu Ile Met Asn Gln Thr Val Cys Ala Leu Leu Met Ala Ala Ser 100 105 110 Trp Val Gly Gly Phe Ile His Ser Ile Val Gln Ile Ala Leu Thr Ile 115 120 125 Gln Leu Pro Phe Cys Gly Pro Asp Lys Leu Asp Asn Phe Tyr Cys Asp 130 135 140 Val Pro Gln Leu Ile Lys Leu Ala Cys Thr Asp Thr Phe Val Leu Glu 145 150 155 160 Leu Leu Met Val Ser Asn Asn Gly Leu Val Thr Leu Met Cys Phe Leu 165 170 175 Val Leu Leu Gly Ser Tyr Thr Ala Leu Leu Val Met Leu Arg Ser His 180 185 190 Ser Arg Glu Gly Arg Ser Lys Ala Leu Ser Thr Cys Ala Ser His Ile 195 200 205 Ala Val Val Thr Leu Ile Phe Val Pro Cys Ile Tyr Val Tyr Thr Arg 210 215 220 Pro Phe Arg Thr Phe Pro Met Asp Lys Ala Val Ser Val Leu Tyr Thr 225 230 235 240 Ile Val Thr Pro Met Leu Asn Pro Ala Ile Tyr Thr Leu Arg Asn Lys 245 250 255 Glu Val Ile Met Ala Met Lys Lys Leu Trp Arg Arg Lys Lys Asp Pro 260 265 270 Ile Gly Pro Leu Glu His Arg Pro Leu His 275 280 <210> 455 <211> 996 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(996) <400> 455 atg tta gag ggt gtt gag cat ctc ctt ctg cta ctt ctt ttg aca gat 48 Met Leu Glu Gly Val Glu His Leu Leu Leu Leu Leu Leu Leu Thr Asp 1 5 10 15 gtg aac agc aag gaa ctg caa agt gga aac cag act tct gtg tct cac 96 Val Asn Ser Lys Glu Leu Gln Ser Gly Asn Gln Thr Ser Val Ser His 20 25 30 ttc att ttg gtg ggc ctg cac cac cca cca cag ctg gga gcg cca ctc 144 Phe Ile Leu Val Gly Leu His His Pro Pro Gln Leu Gly Ala Pro Leu 35 40 45 ttc tta gct ttc ctt gtc atc tat ctc ctc act gtt tct gga aat ggg 192 Phe Leu Ala Phe Leu Val Ile Tyr Leu Leu Thr Val Ser Gly Asn Gly 50 55 60 ctc atc atc ctc act gtc tta gtg gac atc cgg ctc cat cgt ccc atg 240 Leu Ile Ile Leu Thr Val Leu Val Asp Ile Arg Leu His Arg Pro Met 65 70 75 80 tgc ttg ttc ctg tgt cac ctc tcc ttc ttg gac atg acc att tct tgt 288 Cys Leu Phe Leu Cys His Leu Ser Phe Leu Asp Met Thr Ile Ser Cys 85 90 95 gct att gtc ccc aag atg ctg gct ggc ttt ctc ttg ggt agt agg att 336 Ala Ile Val Pro Lys Met Leu Ala Gly Phe Leu Leu Gly Ser Arg Ile 100 105 110 atc tcc ttt ggg ggc tgt gta atc caa cta ttt tct ttc cat ttc ctg 384 Ile Ser Phe Gly Gly Cys Val Ile Gln Leu Phe Ser Phe His Phe Leu 115 120 125 ggc tgt act gag tgc ttc ctt tac aca ctc atg gct tat gac cgt ttc 432 Gly Cys Thr Glu Cys Phe Leu Tyr Thr Leu Met Ala Tyr Asp Arg Phe 130 135 140 ctt gcc att tgt aag ccc tta cac tat gct acc atc atg acc cac aga 480 Leu Ala Ile Cys Lys Pro Leu His Tyr Ala Thr Ile Met Thr His Arg 145 150 155 160 gtc tgt aac tcc ctg gct tta ggc acc tgg ctg gga ggg act atc cat 528 Val Cys Asn Ser Leu Ala Leu Gly Thr Trp Leu Gly Gly Thr Ile His 165 170 175 tca ctt ttc caa aca agt ttt gta ttc cgg ctg ccc ttc tgt ggc ccc 576 Ser Leu Phe Gln Thr Ser Phe Val Phe Arg Leu Pro Phe Cys Gly Pro 180 185 190 aat cgg gtc gac tac atc ttc tgt gac att cct gcc atg ctg cgt cta 624 Asn Arg Val Asp Tyr Ile Phe Cys Asp Ile Pro Ala Met Leu Arg Leu 195 200 205 gcc tgc gcc gat acg gcc atc aac gag ctg gtc acc ttt gca gac att 672 Ala Cys Ala Asp Thr Ala Ile Asn Glu Leu Val Thr Phe Ala Asp Ile 210 215 220 ggc ttc ctg gcc ctc acc tgc ttc atg ctc atc ctc act tcc tat ggc 720 Gly Phe Leu Ala Leu Thr Cys Phe Met Leu Ile Leu Thr Ser Tyr Gly 225 230 235 240 tat att gta gct gcc atc ctg cga att ccg tca gca gat ggg cgc cgc 768 Tyr Ile Val Ala Ala Ile Leu Arg Ile Pro Ser Ala Asp Gly Arg Arg 245 250 255 aat gcc ttc tcc act tgt gct gcc cac ctc act gtt gtc att gtt tac 816 Asn Ala Phe Ser Thr Cys Ala Ala His Leu Thr Val Val Ile Val Tyr 260 265 270 tat gtg cct gca cct tca ttt acc tgc ggc ctt gtt cac agg agc cct 864 Tyr Val Pro Ala Pro Ser Phe Thr Cys Gly Leu Val His Arg Ser Pro 275 280 285 gga nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 912 Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 290 295 300 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 960 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 305 310 315 320 nnn nnn nct aga tca gca tgc cca ata gac ata taa 996 Xaa Xaa Xaa Arg Ser Ala Cys Pro Ile Asp Ile 325 330 <210> 456 <211> 331 <212> PRT <213> Homo sapiens <400> 456 Met Leu Glu Gly Val Glu His Leu Leu Leu Leu Leu Leu Leu Thr Asp 1 5 10 15 Val Asn Ser Lys Glu Leu Gln Ser Gly Asn Gln Thr Ser Val Ser His 20 25 30 Phe Ile Leu Val Gly Leu His His Pro Pro Gln Leu Gly Ala Pro Leu 35 40 45 Phe Leu Ala Phe Leu Val Ile Tyr Leu Leu Thr Val Ser Gly Asn Gly 50 55 60 Leu Ile Ile Leu Thr Val Leu Val Asp Ile Arg Leu His Arg Pro Met 65 70 75 80 Cys Leu Phe Leu Cys His Leu Ser Phe Leu Asp Met Thr Ile Ser Cys 85 90 95 Ala Ile Val Pro Lys Met Leu Ala Gly Phe Leu Leu Gly Ser Arg Ile 100 105 110 Ile Ser Phe Gly Gly Cys Val Ile Gln Leu Phe Ser Phe His Phe Leu 115 120 125 Gly Cys Thr Glu Cys Phe Leu Tyr Thr Leu Met Ala Tyr Asp Arg Phe 130 135 140 Leu Ala Ile Cys Lys Pro Leu His Tyr Ala Thr Ile Met Thr His Arg 145 150 155 160 Val Cys Asn Ser Leu Ala Leu Gly Thr Trp Leu Gly Gly Thr Ile His 165 170 175 Ser Leu Phe Gln Thr Ser Phe Val Phe Arg Leu Pro Phe Cys Gly Pro 180 185 190 Asn Arg Val Asp Tyr Ile Phe Cys Asp Ile Pro Ala Met Leu Arg Leu 195 200 205 Ala Cys Ala Asp Thr Ala Ile Asn Glu Leu Val Thr Phe Ala Asp Ile 210 215 220 Gly Phe Leu Ala Leu Thr Cys Phe Met Leu Ile Leu Thr Ser Tyr Gly 225 230 235 240 Tyr Ile Val Ala Ala Ile Leu Arg Ile Pro Ser Ala Asp Gly Arg Arg 245 250 255 Asn Ala Phe Ser Thr Cys Ala Ala His Leu Thr Val Val Ile Val Tyr 260 265 270 Tyr Val Pro Ala Pro Ser Phe Thr Cys Gly Leu Val His Arg Ser Pro 275 280 285 Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 290 295 300 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 305 310 315 320 Xaa Xaa Xaa Arg Ser Ala Cys Pro Ile Asp Ile 325 330 <210> 457 <211> 921 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(921) <400> 457 atg cag agg agc aat cac aca gtg act gag ttc atc ctg ctg ggc ttc 48 Met Gln Arg Ser Asn His Thr Val Thr Glu Phe Ile Leu Leu Gly Phe 1 5 10 15 acc aca gat cca ggg atg caa ctg ggc ctc ttt gtg gtg ttc ctg ggt 96 Thr Thr Asp Pro Gly Met Gln Leu Gly Leu Phe Val Val Phe Leu Gly 20 25 30 gtg tac tgt ctg act gtg gta gga agt agc acc ctc atc gtg ttg atc 144 Val Tyr Cys Leu Thr Val Val Gly Ser Ser Thr Leu Ile Val Leu Ile 35 40 45 tgt aat gac tcc cgc cta cac aca ccc atg tat ttt gtc att gga aat 192 Cys Asn Asp Ser Arg Leu His Thr Pro Met Tyr Phe Val Ile Gly Asn 50 55 60 ctg tca ttt ctg gat ctc tgg tat tct tct gtc cac acc cca aag atc 240 Leu Ser Phe Leu Asp Leu Trp Tyr Ser Ser Val His Thr Pro Lys Ile 65 70 75 80 cta gtg acc tgc atc tct gaa gac aaa agc atc tcc ttt gct ggc tgc 288 Leu Val Thr Cys Ile Ser Glu Asp Lys Ser Ile Ser Phe Ala Gly Cys 85 90 95 ctg tgt cag ttc ttc tct gcc agg ctg gcc tat agt gag tgc tac cta 336 Leu Cys Gln Phe Phe Ser Ala Arg Leu Ala Tyr Ser Glu Cys Tyr Leu 100 105 110 ctg gct gcc atg gct tat gac cac tac gtg gcc atc tcc aag ccc ctg 384 Leu Ala Ala Met Ala Tyr Asp His Tyr Val Ala Ile Ser Lys Pro Leu 115 120 125 ctt tat gct cag acc atg cca agg aga ttg tgc atc tgt ttg gtt tta 432 Leu Tyr Ala Gln Thr Met Pro Arg Arg Leu Cys Ile Cys Leu Val Leu 130 135 140 tat tcc tat act ggg ggt ttt gtc aat gca ata ata tta acc agc aac 480 Tyr Ser Tyr Thr Gly Gly Phe Val Asn Ala Ile Ile Leu Thr Ser Asn 145 150 155 160 aca ttc aca ttg gat ttt tgt ggt gac aat gtc att gat gac ttt ttc 528 Thr Phe Thr Leu Asp Phe Cys Gly Asp Asn Val Ile Asp Asp Phe Phe 165 170 175 tgt gat gtt cca ccc ctc gtg aag ctg gca tgc agt gtg aga gag agc 576 Cys Asp Val Pro Pro Leu Val Lys Leu Ala Cys Ser Val Arg Glu Ser 180 185 190 tac cag gct gtg ctg cac ttc ctt ctg gcc tcc aat gtc atc tcc cct 624 Tyr Gln Ala Val Leu His Phe Leu Leu Ala Ser Asn Val Ile Ser Pro 195 200 205 act gtg ctc atc ctt gcc tct tac ctc tcc atc atc acc acc atc ctg 672 Thr Val Leu Ile Leu Ala Ser Tyr Leu Ser Ile Ile Thr Thr Ile Leu 210 215 220 agg atc cac tct acc cag ggc cgc atc aaa gtc ttc tcc aca tgc tcc 720 Arg Ile His Ser Thr Gln Gly Arg Ile Lys Val Phe Ser Thr Cys Ser 225 230 235 240 tcc cac ctg atc tcc gtt acc tta tac tat ggc tcc att ctc tac aac 768 Ser His Leu Ile Ser Val Thr Leu Tyr Tyr Gly Ser Ile Leu Tyr Asn 245 250 255 tac tcc cgg cca agt tcc agc tac tcc ctc aag agg gac aaa atg gtt 816 Tyr Ser Arg Pro Ser Ser Ser Tyr Ser Leu Lys Arg Asp Lys Met Val 260 265 270 tct acc ttt tat act atg ctg ttc ccc atg ttg aat ccc atg atc tac 864 Ser Thr Phe Tyr Thr Met Leu Phe Pro Met Leu Asn Pro Met Ile Tyr 275 280 285 agt ctg agg agt aaa gac atg aaa gac gct ctg aaa aaa ttc ttc aag 912 Ser Leu Arg Ser Lys Asp Met Lys Asp Ala Leu Lys Lys Phe Phe Lys 290 295 300 t ca gca taa 921 Ser Ala 305 <210> 458 <211> 306 <212> PRT <213> Homo sapiens <400> 458 Met Gln Arg Ser Asn His Thr Val Thr Glu Phe Ile Leu Leu Gly Phe 1 5 10 15 Thr Thr Asp Pro Gly Met Gln Leu Gly Leu Phe Val Val Phe Leu Gly 20 25 30 Val Tyr Cys Leu Thr Val Val Gly Ser Ser Thr Leu Ile Val Leu Ile 35 40 45 Cys Asn Asp Ser Arg Leu His Thr Pro Met Tyr Phe Val Ile Gly Asn 50 55 60 Leu Ser Phe Leu Asp Leu Trp Tyr Ser Ser Val His Thr Pro Lys Ile 65 70 75 80 Leu Val Thr Cys Ile Ser Glu Asp Lys Ser Ile Ser Phe Ala Gly Cys 85 90 95 Leu Cys Gln Phe Phe Ser Ala Arg Leu Ala Tyr Ser Glu Cys Tyr Leu 100 105 110 Leu Ala Ala Met Ala Tyr Asp His Tyr Val Ala Ile Ser Lys Pro Leu 115 120 125 Leu Tyr Ala Gln Thr Met Pro Arg Arg Leu Cys Ile Cys Leu Val Leu 130 135 140 Tyr Ser Tyr Thr Gly Gly Phe Val Asn Ala Ile Ile Leu Thr Ser Asn 145 150 155 160 Thr Phe Thr Leu Asp Phe Cys Gly Asp Asn Val Ile Asp Asp Phe Phe 165 170 175 Cys Asp Val Pro Pro Leu Val Lys Leu Ala Cys Ser Val Arg Glu Ser 180 185 190 Tyr Gln Ala Val Leu His Phe Leu Leu Ala Ser Asn Val Ile Ser Pro 195 200 205 Thr Val Leu Ile Leu Ala Ser Tyr Leu Ser Ile Ile Thr Thr Ile Leu 210 215 220 Arg Ile His Ser Thr Gln Gly Arg Ile Lys Val Phe Ser Thr Cys Ser 225 230 235 240 Ser His Leu Ile Ser Val Thr Leu Tyr Tyr Gly Ser Ile Leu Tyr Asn 245 250 255 Tyr Ser Arg Pro Ser Ser Ser Tyr Ser Leu Lys Arg Asp Lys Met Val 260 265 270 Ser Thr Phe Tyr Thr Met Leu Phe Pro Met Leu Asn Pro Met Ile Tyr 275 280 285 Ser Leu Arg Ser Lys Asp Met Lys Asp Ala Leu Lys Lys Phe Phe Lys 290 295 300 Ser Ala 305 <210> 459 <211> 918 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(918) <400> 459 atg tat ctg gtc acg gtg ctg agg aac ctg ctc agc atc ctg gct gtc 48 Met Tyr Leu Val Thr Val Leu Arg Asn Leu Leu Ser Ile Leu Ala Val 1 5 10 15 agc tct gac tcc cac ccc cac aca ccc atg tac ttc ttc ctc tcc aac 96 Ser Ser Asp Ser His Pro His Thr Pro Met Tyr Phe Phe Leu Ser Asn 20 25 30 ctg tgc tgg gct gac atc ggt ttc acc ttg gcc acg gtt ccc aaa atg 144 Leu Cys Trp Ala Asp Ile Gly Phe Thr Leu Ala Thr Val Pro Lys Met 35 40 45 att gtg gac atg ggg tcg cat agc aaa gtc atc tct tat ggg ggc tgc 192 I le Val Asp Met Gly Ser His Ser Lys Val Ile Ser Tyr Gly Gly Cys 50 55 60 ctg aca cag atg tct ttc ttg gta ctt ttt gca tgt ata gta gac atg 240 Leu Thr Gln Met Ser Phe Leu Val Leu Phe Ala Cys Ile Val Asp Met 65 70 75 80 ttc ctg act gtg atg gct tat gac tgc ttt gta gcc atc tgt cgc cct 288 Phe Leu Thr Val Met Ala Tyr Asp Cys Phe Val Ala Ile Cys Arg Pro 85 90 95 ctg cac tac cca gtc atc gtg aat cct cac ctc tgt gtc ttc ttc gtt 336 Leu His Tyr Pro Val Ile Val Asn Pro His Leu Cys Val Phe Phe Val 100 105 110 ttg gtg tcc ttt ttc ctt agc ctg ttg gat tcc cag ctg cac agt tgg 384 Leu Val Ser Phe Phe Leu Ser Leu Leu Asp Ser Gln Leu His Ser Trp 115 120 125 att gtg tta caa ttc acc ttc ttc aag aat gtg gaa atc tct aat ttt 432 Ile Val Leu Gln Phe Thr Phe Phe Lys Asn Val Glu Ile Ser Asn Phe 130 135 140 gtc tgt gag cca tct caa ctt ctc aag ctt gcc tct tat gac agc gtc 480 Val Cys Glu Pro Ser Gln Leu Leu Lys Leu Ala Ser Tyr Asp Ser Val 145 150 155 160 atc aat agc ata ttc ata tat ttt gat aat act atg ttt ggt ttt ctt 528 Ile Asn Ser Ile Phe Ile Tyr Phe Asp Asn Thr Met Phe Gly Phe Leu 165 170 175 ccc att tca ggg atc ctt ttg tct tac tat aaa att gtc ccc tcc att 576 Pro Ile Ser Gly Ile Leu Leu Ser Tyr Tyr Lys Ile Val Pro Ser Ile 180 185 190 cta agg att tca tca tca gat ggg aag tac aaa gcc ttc tca gcc tgt 624 Leu Arg Ile Ser Ser Ser Asp Gly Lys Tyr Lys Ala Phe Ser Ala Cys 195 200 205 ggc tgt cac ctg gca gtt gtt tgc tta ttt tat gga aca ggc att ggc 672 Gly Cys His Leu Ala Val Val Cys Leu Phe Tyr Gly Thr Gly Ile Gly 210 215 220 gtg tac ctg act tca gct gtg gca cca ccc ctc agg aat ggt atg gtg 720 Val Tyr Leu Thr Ser Ala Val Ala Pro Pro Leu Arg Asn Gly Met Val 225 230 235 240 gcg tca gtg atg tac gct gtg gtc acc ccc atg ctg aac cct ttc atc 768 Ala Ser Val Met Tyr Ala Val Val Thr Pro Met Leu Asn Pro Phe Ile 245 250 255 tac agc ctg aga aac agg gac att caa agt gcc ctg tgg agg gtg tgc 816 Tyr Ser Leu Arg Asn Arg Asp Ile Gln Ser Ala Leu Trp Arg Val Cys 260 265 270 aac aaa aca gtc gaa tct cat gat ctg ttc cat cct ttt tct tgt gtg 864 Asn Lys Thr Val Glu Ser His Asp Leu Phe His Pro Phe Ser Cys Val 275 280 285 gtt gag aaa ggg caa cca cat tca atc cct aca tct gca aat cct gcc 912 Val Glu Lys Gly Gln Pro His Ser Ile Pro Thr Ser Ala Asn Pro Ala 290 295 300 cct tag 918 Pro 305 <210> 460 <211> 305 <212> PRT <213> Homo sapiens <400> 460 Met Tyr Leu Val Thr Val Leu Arg Asn Leu Leu Ser Ile Leu Ala Val 1 5 10 15 Ser Ser Asp Ser His Pro His Thr Pro Met Tyr Phe Phe Leu Ser Asn 20 25 30 Leu Cys Trp Ala Asp Ile Gly Phe Thr Leu Ala Thr Val Pro Lys Met 35 40 45 Ile Val Asp Met Gly Ser His Ser Lys Val Ile Ser Tyr Gly Gly Cys 50 55 60 Leu Thr Gln Met Ser Phe Leu Val Leu Phe Ala Cys Ile Val Asp Met 65 70 75 80 Phe Leu Thr Val Met Ala Tyr Asp Cys Phe Val Ala Ile Cys Arg Pro 85 90 95 Leu His Tyr Pro Val Ile Val Asn Pro His Leu Cys Val Phe Phe Val 100 105 110 Leu Val Ser Phe Phe Leu Ser Leu Leu Asp Ser Gln Leu His Ser Trp 115 120 125 Ile Val Leu Gln Phe Thr Phe Phe Lys Asn Val Glu Ile Ser Asn Phe 130 135 140 Val Cys Glu Pro Ser Gln Leu Leu Lys Leu Ala Ser Tyr Asp Ser Val 145 150 155 160 Ile Asn Ser Ile Phe Ile Tyr Phe Asp Asn Thr Met Phe Gly Phe Leu 165 170 175 Pro Ile Ser Gly Ile Leu Leu Ser Tyr Tyr Lys Ile Val Pro Ser Ile 180 185 190 Leu Arg Ile Ser Ser Ser Asp Gly Lys Tyr Lys Ala Phe Ser Ala Cys 195 200 205 Gly Cys His Leu Ala Val Val Cys Leu Phe Tyr Gly Thr Gly Ile Gly 210 215 220 Val Tyr Leu Thr Ser Ala Val Ala Pro Pro Leu Arg Asn Gly Met Val 225 230 235 240 Ala Ser Val Met Tyr Ala Val Val Thr Pro Met Leu Asn Pro Phe Ile 245 250 255 Tyr Ser Leu Arg Asn Arg Asp Ile Gln Ser Ala Leu Trp Arg Val Cys 260 265 270 Asn Lys Thr Val Glu Ser His Asp Leu Phe His Pro Phe Ser Cys Val 275 280 285 Val Glu Lys Gly Gln Pro His Ser Ile Pro Thr Ser Ala Asn Pro Ala 290 295 300 Pro 305 <210> 461 <211> 771 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(771) <400> 461 atg gtc ttg ata ttg cgg tat cat tac tct gaa tta att cca atc tcc 48 M et Val Leu Ile Leu Arg Tyr His Tyr Ser Glu Leu Ile Pro Ile Ser 1 5 10 15 ata tca tta aca ggc atc aag aaa cac aaa tcc atg gct gat gtt aat 96 Ile Ser Leu Thr Gly Ile Lys Lys His Lys Ser Met Ala Asp Val Asn 20 25 30 ttt aca ttg gtt act gag ttt atc ctt ttg gaa ctg aca gat cgt gct 144 Phe Thr Leu Val Thr Glu Phe Ile Leu Leu Glu Leu Thr Asp Arg Ala 35 40 45 gaa ctg aag atg gtc ctc ttc gtg ttg ttc ctg ctg atc tac acc att 192 Glu Leu Lys Met Val Leu Phe Val Leu Phe Leu Leu Ile Tyr Thr Ile 50 55 60 tcc ctg gtg gga aat ata gga atg ctc ttt cta atc tat gta act ccc 240 Ser Leu Val Gly Asn Ile Gly Met Leu Phe Leu Ile Tyr Val Thr Pro 65 70 75 80 aaa ctc cac aca ccc atg tat tat ttc ctc agc tgt ctg tca ttt gtt 288 Lys Leu His Thr Pro Met Tyr Tyr Phe Leu Ser Cys Leu Ser Phe Val 85 90 95 gat gcc tgc tat tca tca gtt ttt gca ccc aga atg ctg ctg aac ttc 336 Asp Ala Cys Tyr Ser Ser Val Phe Ala Pro Arg Met Leu Leu Asn Phe 100 105 110 ttt gtt gag cgg gag aca atc tta ttc tct gca tgt att gtg cag tat 384 Phe Val Glu Arg Glu Thr Ile Leu Phe Ser Ala Cys Ile Val Gln Tyr 115 120 125 ttt tta ttc gtg tct ctc ctt acc act gag ggc ttc ttg ctg gcc aca 432 Phe Leu Phe Val Ser Leu Leu Thr Thr Glu Gly Phe Leu Leu Ala Thr 130 135 140 atg gct tac gac cgt tac atg gcc att gtg aac cct tta ctt tat aca 480 Met Ala Tyr Asp Arg Tyr Met Ala Ile Val Asn Pro Leu Leu Tyr Thr 145 150 155 160 gta gct atg act aaa ata gtt tgt att gtg ctc gca ttt ggg tca tgt 528 Val Ala Met Thr Lys Ile Val Cys Ile Val Leu Ala Phe Gly Ser Cys 165 170 175 atg gga ggt tta atc aac tca ttg aca cat aca att ggc ttg gtg aaa 576 Met Gly Gly Leu Ile Asn Ser Leu Thr His Thr Ile Gly Leu Val Lys 180 185 190 ctg tct ttc tgt ggg cca aat gtc atc agt cac ttc ttc tgt gat ctt 624 Leu Ser Phe Cys Gly Pro Asn Val Ile Ser His Phe Phe Cys Asp Leu 195 200 205 ccc cca ctg ttg aag ctg tca tgt tct gag aca tct atg aat gaa ttg 672 Pro Pro Leu Leu Lys Leu Ser Cys Ser Glu Thr Ser Met Asn Glu Leu 210 215 220 ttg ctt ttg atc ttc tct ggc att att gcc acg ctc act ttt ttg act 720 Leu Leu Leu Ile Phe Ser Gly Ile Ile Ala Thr Leu Thr Phe Leu Thr 225 230 235 240 gtg gtg atc tcc tac atc ttc att gtt gct gct atc ctg agg atc cgc 768 Val Val Ile Ser Tyr Ile Phe Ile Val Ala Ala Ile Leu Arg Ile Arg 245 250 255 taa 771 <210> 462 <211> 256 <212> PRT <213> Homo sapiens <400> 462 Met Val Leu Ile Leu Arg Tyr His Tyr Ser Glu Leu Ile Pro Ile Ser 1 5 10 15 Ile Ser Leu Thr Gly Ile Lys Lys His Lys Ser Met Ala Asp Val Asn 20 25 30 Phe Thr Leu Val Thr Glu Phe Ile Leu Leu Glu Leu Thr Asp Arg Ala 35 40 45 Glu Leu Lys Met Val Leu Phe Val Leu Phe Leu Leu Ile Tyr Thr Ile 50 55 60 Ser Leu Val Gly Asn Ile Gly Met Leu Phe Leu Ile Tyr Val Thr Pro 65 70 75 80 Lys Leu His Thr Pro Met Tyr Tyr Phe Leu Ser Cys Leu Ser Phe Val 85 90 95 Asp Ala Cys Tyr Ser Ser Val Phe Ala Pro Arg Met Leu Leu Asn Phe 100 105 110 Phe Val Glu Arg Glu Thr Ile Leu Phe Ser Ala Cys Ile Val Gln Tyr 115 120 125 Phe Leu Phe Val Ser Leu Leu Thr Thr Glu Gly Phe Leu Leu Ala Thr 130 135 140 Met Ala Tyr Asp Arg Tyr Met Ala Ile Val Asn Pro Leu Leu Tyr Thr 145 150 155 160 Val Ala Met Thr Lys Ile Val Cys Ile Val Leu Ala Phe Gly Ser Cys 165 170 175 Met Gly Gly Leu Ile Asn Ser Leu Thr His Thr Ile Gly Leu Val Lys 180 185 190 Leu Ser Phe Cys Gly Pro Asn Val Ile Ser His Phe Phe Cys Asp Leu 195 200 205 Pro Pro Leu Leu Lys Leu Ser Cys Ser Glu Thr Ser Met Asn Glu Leu 210 215 220 Leu Leu Leu Ile Phe Ser Gly Ile Ile Ala Thr Leu Thr Phe Leu Thr 225 230 235 240 Val Val Ile Ser Tyr Ile Phe Ile Val Ala Ala Ile Leu Arg Ile Arg 245 250 255 <210> 463 <211> 939 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(939) <400> 463 atg atg ggt aga agg aat gac aca aat gtg gct gac ttc atc ctt acg 48 Met Met Gly Arg Arg Asn Asp Thr Asn Val Ala Asp Phe Ile Leu Thr 1 5 10 15 gga ctg tca gac tct gaa gag gtc cag atg gct ctg ttt atg cta ttt 96 Gly Leu Ser Asp Ser Glu Glu Val Gln Met Ala Leu Phe Met Leu Phe 20 25 30 ctc ctc ata tac cta att act atg ctg ggg aat gtg ggg atg cta ttg 144 Leu Leu Ile Tyr Leu Ile Thr Met Leu Gly Asn Val Gly Met Leu Leu 35 40 45 ata atc cgc ctg gac ctc cag ctt cac act ccc atg tat ttt ttc ctt 192 Ile Ile Arg Leu Asp Leu Gln Leu His Thr Pro Met Tyr Phe Phe Leu 50 55 60 act cac ctg tca ttt att gac ctc agt tac tca act gtc gtc aca cct 240 Thr His Leu Ser Phe Ile Asp Leu Ser Tyr Ser Thr Val Val Thr Pro 65 70 75 80 aaa acc tta gcg aac tta ctg act tcc aac tat att tcc ttc acg ggc 288 Lys Thr Leu Ala Asn Leu Leu Thr Ser Asn Tyr Ile Ser Phe Thr Gly 85 90 95 tgc ttt gcc cag atg ttc tgt ttt gtc ttc ttg ggt act gct gaa tgt 336 Cys Phe Ala Gln Met Phe Cys Phe Val Phe Leu Gly Thr Ala Glu Cys 100 105 110 tat ctt ctc tcc tca atg gcc tat gat cgc tat gca gcg atc tgc agt 384 Tyr Leu Leu Ser Ser Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys Ser 115 120 125 cct cta cac tac aca gtt att atg ccc aaa agg ctc tgc ctc gct ctc 432 Pro Leu His Tyr Thr Val Ile Met Pro Lys Arg Leu Cys Leu Ala Leu 130 135 140 atc act ggg cct tat gtg att ggc ttt atg gac tcc ttt gtc aat gtg 480 Ile Thr Gly Pro Tyr Val Ile Gly Phe Met Asp Ser Phe Val Asn Val 145 150 155 160 gtt tcc atg agc aga ttg cat ttc tgt gac tca aac ata att cat cac 528 Val Ser Met Ser Arg Leu His Phe Cys Asp Ser Asn Ile Ile His His 165 170 175 ttt ttc tgt gac act tcc cca att tta gct ctg tcc tgc act gac aca 576 Phe Phe Cys Asp Thr Ser Pro Ile Leu Ala Leu Ser Cys Thr Asp Thr 180 185 190 gac aac act gaa atg ctg ata ttc att atc gct ggt tcc acc ctg atg 624 Asp Asn Thr Glu Met Leu Ile Phe Ile Ile Ala Gly Ser Thr Leu Met 195 200 205 gtg tcc ctt atc aca ata tct gca tcc tat gtg tcc att ctc tct acc 672 Val Ser Leu Ile Thr Ile Ser Ala Ser Tyr Val Ser Ile Leu Ser Thr 210 215 220 atc ctg aaa att aat tcc act tca gga aag cag aaa gct ttc tct act 720 Ile Leu Lys Ile Asn Ser Thr Ser Gly Lys Gln Lys Ala Phe Ser Thr 225 230 235 240 tgc gtc tct cat ctc ttg gga gtc acc atc ttc tat gga act atg att 768 Cys Val Ser His Leu Leu Gly Val Thr Ile Phe Tyr Gly Thr Met Ile 245 250 255 ttt act tac tta aag cca aga aag tct tat tcc ttg gga aga gat caa 816 Phe Thr Tyr Leu Lys Pro Arg Lys Ser Tyr Ser Leu Gly Arg Asp Gln 260 265 270 gtg gct cct gtg ttt tat act att gtg att ccc atg ctg aat cca ctc 864 Val Ala Pro Val Phe Tyr Thr Ile Val Ile Pro Met Leu Asn Pro Leu 275 280 285 att tat agt ctt aga aac aga gaa gtg aaa aat gct ctc att aga gtc 912 Ile Tyr Ser Leu Arg Asn Arg Glu Val Lys Asn Ala Leu Ile Arg Val 290 295 300 atg cag aga aga cag gac tcc agg tag 939 Met Gln Arg Arg Gln Asp Ser Arg 305 310 <210> 464 <211> 312 <212> PRT <213> Homo sapiens <400> 464 Met Met Gly Arg Arg Asn Asp Thr Asn Val Ala Asp Phe Ile Leu Thr 1 5 10 15 Gly Leu Ser Asp Ser Glu Glu Val Gln Met Ala Leu Phe Met Leu Phe 20 25 30 Leu Leu Ile Tyr Leu Ile Thr Met Leu Gly Asn Val Gly Met Leu Leu 35 40 45 Ile Ile Arg Leu Asp Leu Gln Leu His Thr Pro Met Tyr Phe Phe Leu 50 55 60 Thr His Leu Ser Phe Ile Asp Leu Ser Tyr Ser Thr Val Val Thr Pro 65 70 75 80 Lys Thr Leu Ala Asn Leu Leu Thr Ser Asn Tyr Ile Ser Phe Thr Gly 85 90 95 Cys Phe Ala Gln Met Phe Cys Phe Val Phe Leu Gly Thr Ala Glu Cys 100 105 110 Tyr Leu Leu Ser Ser Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys Ser 115 120 125 Pro Leu His Tyr Thr Val Ile Met Pro Lys Arg Leu Cys Leu Ala Leu 130 135 140 Ile Thr Gly Pro Tyr Val Ile Gly Phe Met Asp Ser Phe Val Asn Val 145 150 155 160 Val Ser Met Ser Arg Leu His Phe Cys Asp Ser Asn Ile Ile His His 165 170 175 Phe Phe Cys Asp Thr Ser Pro Ile Leu Ala Leu Ser Cys Thr Asp Thr 180 185 190 Asp Asn Thr Glu Met Leu Ile Phe Ile Ile Ala Gly Ser Thr Leu Met 195 200 205 Val Ser Leu Ile Thr Ile Ser Ala Ser Tyr Val Ser Ile Leu Ser Thr 210 215 220 Ile Leu Lys Ile Asn Ser Thr Ser Gly Lys Gln Lys Ala Phe Ser Thr 225 230 235 240 Cys Val Ser His Leu Leu Gly Val Thr Ile Phe Tyr Gly Thr Met Ile 245 250 255 Phe Thr Tyr Leu Lys Pro Arg Lys Ser Tyr Ser Leu Gly Arg Asp Gln 260 265 270 Val Ala Pro Val Phe Tyr Thr Ile Val Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Glu Val Lys Asn Ala Leu Ile Arg Val 290 295 300 Met Gln Arg Arg Gln Asp Ser Arg 305 310 <210> 465 <211> 801 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(801) <400> 465 atg tat tat ttt ctt agc aac tta tct ttc tta gac atc agc tgt tct 48 Met Tyr Tyr Phe Leu Ser Asn Leu Ser Phe Leu Asp Ile Ser Cys Ser 1 5 10 15 aca gca atc act cct aaa atg ctg gca aac ttc ttg gca tcc agg aaa 96 Thr Ala Ile Thr Pro Lys Met Leu Ala Asn Phe Leu Ala Ser Arg Lys 20 25 30 agc atc tct cct tat ggg tgt gca cta caa atg ttt ttc ttc gct tct 144 Ser Ile Ser Pro Tyr Gly Cys Ala Leu Gln Met Phe Phe Phe Ala Ser 35 40 45 ttt gct gat gct gag tgc ctt atc ctg gca gca atg gct tat gac cgc 192 Phe Ala Asp Ala Glu Cys Leu Ile Leu Ala Ala Met Ala Tyr Asp Arg 50 55 60 tat gca gcc atc tgc aac cca ctg ctc tat act aca ctg atg tct agg 240 Tyr Ala Ala Ile Cys Asn Pro Leu Leu Tyr Thr Thr Leu Met Ser Arg 65 70 75 80 aga gtc tgt gtc tgc ttc att gtg ttg gca tat ttc agt gga agt aca 288 Arg Val Cys Val Cys Phe Ile Val Leu Ala Tyr Phe Ser Gly Ser Thr 85 90 95 aca tca ctg gtc cat gtg tgc ctc aca ttc agg ctg tca ttt tgt ggc 336 Thr Ser Leu Val His Val Cys Leu Thr Phe Arg Leu Ser Phe Cys Gly 100 105 110 tcc aat atc gtc aat cat ttt ttc tgt gat atc cca cct ctt ctg gct 384 Ser Asn Ile Val Asn His Phe Phe Cys Asp Ile Pro Pro Leu Leu Ala 115 120 125 tta tca tgt aca gac act cag atc aac cag ctt ctg ctc ttt gct ttg 432 Leu Ser Cys Thr Asp Thr Gln Ile Asn Gln Leu Leu Leu Phe Ala Leu 130 135 140 tgc agc ttc atc cag acc agc act ttt gtg gta ata ttt att tct tac 480 Cys Ser Phe Ile Gln Thr Ser Thr Phe Val Val Ile Phe Ile Ser Tyr 145 150 155 160 ttc tgc atc ctc atc act gtg ttg agc atc aag tcc tca ggt ggc aga 528 Phe Cys Ile Leu Ile Thr Val Leu Ser Ile Lys Ser Ser Gly Gly Arg 165 170 175 agc aaa aca ttc tcc act tgt gct tcc cac ctc ata gca gtc acc tta 576 Ser Lys Thr Phe Ser Thr Cys Ala Ser His Leu Ile Ala Val Thr Leu 180 185 190 ttc tat gga gcg ctc ctg ttt atg tac tta cag ccc acc act agc tat 624 Phe Tyr Gly Ala Leu Leu Phe Met Tyr Leu Gln Pro Thr Thr Ser Tyr 195 200 205 tcc cta gac act gat aag gtg gtg gca gtg ttt tat act gtt gta ttt 672 Ser Leu Asp Thr Asp Lys Val Val Ala Val Phe Tyr Thr Val Val Phe 210 215 220 ccc atg ttt aat cca ata att tat agt ttc aga aac aag gat gtg aaa 720 Pro Met Phe Asn Pro Ile Ile Tyr Ser Phe Arg Asn Lys Asp Val Lys 225 230 235 240 aat gct ctc aaa aag cta tta gaa aga att gga tat tca aat gaa tgg 768 Asn Ala Leu Lys Lys Leu Leu Glu Arg Ile Gly Tyr Ser Asn Glu Trp 245 250 255 tat tta aat cgt tta aga ata gtc aat atc taa 801 Tyr Leu Asn Arg Leu Arg Ile Val Asn Ile 260 265 <210> 466 <211> 266 <212> PRT <213> Homo sapiens <400> 466 Met Tyr Tyr Phe Leu Ser Asn Leu Ser Phe Leu Asp Ile Ser Cys Ser 1 5 10 15 Thr Ala Ile Thr Pro Lys Met Leu Ala Asn Phe Leu Ala Ser Arg Lys 20 25 30 Ser Ile Ser Pro Tyr Gly Cys Ala Leu Gln Met Phe Phe Phe Ala Ser 35 40 45 Phe Ala Asp Ala Glu Cys Leu Ile Leu Ala Ala Met Ala Tyr Asp Arg 50 55 60 Tyr Ala Ala Ile Cys Asn Pro Leu Leu Tyr Thr Thr Leu Met Ser Arg 65 70 75 80 Arg Val Cys Val Cys Phe Ile Val Leu Ala Tyr Phe Ser Gly Ser Thr 85 90 95 Thr Ser Leu Val His Val Cys Leu Thr Phe Arg Leu Ser Phe Cys Gly 100 105 110 Ser Asn Ile Val Asn His Phe Phe Cys Asp Ile Pro Pro Leu Leu Ala 115 120 125 Leu Ser Cys Thr Asp Thr Gln Ile Asn Gln Leu Leu Leu Phe Ala Leu 130 135 140 Cys Ser Phe Ile Gln Thr Ser Thr Phe Val Val Ile Phe Ile Ser Tyr 145 150 155 160 Phe Cys Ile Leu Ile Thr Val Leu Ser Ile Lys Ser Ser Gly Gly Arg 165 170 175 Ser Lys Thr Phe Ser Thr Cys Ala Ser His Leu Ile Ala Val Thr Leu 180 185 190 Phe Tyr Gly Ala Leu Leu Phe Met Tyr Leu Gln Pro Thr Thr Ser Tyr 195 200 205 Ser Leu Asp Thr Asp Lys Val Val Ala Val Phe Tyr Thr Val Val Phe 210 215 220 Pro Met Phe Asn Pro Ile Ile Tyr Ser Phe Arg Asn Lys Asp Val Lys 225 230 235 240 Asn Ala Leu Lys Lys Leu Leu Glu Arg Ile Gly Tyr Ser Asn Glu Trp 245 250 255 Tyr Leu Asn Arg Leu Arg Ile Val Asn Ile 260 265 <210> 467 <211> 933 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(933) <400> 467 atg gct ggc aac aat ttc act gag gtt acc gtc ttc atc ctc tct gga 48 Met Ala Gly Asn Asn Phe Thr Glu Val Thr Val Phe Ile Leu Ser Gly 1 5 10 15 ttt gca aat cac cct gaa tta caa gtc agt ctt ttc ttg atg ttt ctc 96 Phe Ala Asn His Pro Glu Leu Gln Val Ser Leu Phe Leu Met Phe Leu 20 25 30 ttc att tat cta ttc act gtt ttg gga aac ctg gga ctg atc acg tta 144 Phe Ile Tyr Leu Phe Thr Val Leu Gly Asn Leu Gly Leu Ile Thr Leu 35 40 45 atc aga atg gat tct cag ctt cac acc cct atg tac ttt ttc ctg agc 192 Ile Arg Met Asp Ser Gln Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 aat tta gca ttt att gac ata ttt tac tcc tct act gta aca cct aag 240 Asn Leu Ala Phe Ile Asp Ile Phe Tyr Ser Ser Thr Val Thr Pro Lys 65 70 75 80 gca ttg gtg aat ttc caa tcc aat cgg aga tcc atc tcc ttt gtt ggc 288 Ala Leu Val Asn Phe Gln Ser Asn Arg Arg Ser Ile Ser Phe Val Gly 85 90 95 tgc ttt gtt caa atg tac ttt ttt gtt gga ttg gtg tgt tgt gag tgt 336 Cys Phe Val Gln Met Tyr Phe Phe Val Gly Leu Val Cys Cys Glu Cys 100 105 110 ttc ctt ctg gga tca atg gcc tac aat cgc tac ata gca atc tgc aat 384 Phe Leu Leu Gly Ser Met Ala Tyr Asn Arg Tyr Ile Ala Ile Cys Asn 115 120 125 ccc tta ctg tat tca gta gtc atg tcc caa aaa gtg tcc aac tgg ctg 432 Pro Leu Leu Tyr Ser Val Val Met Ser Gln Lys Val Ser Asn Trp Leu 130 135 140 gga gta atg cca tat gtg ata ggc ttc aca agc tcg ctg ata tct gtc 480 Gly Val Met Pro Tyr Val Ile Gly Phe Thr Ser Ser Leu Ile Ser Val 145 150 155 160 tgg gtg ata agc agt ttg gcg ttc tgt gat tcc agc atc aat cat ttt 528 Trp Val Ile Ser Ser Leu Ala Phe Cys Asp Ser Ser Ile Asn His Phe 165 170 175 ttt tgt gac acc aca gct ctt tta gca ctc tcc tgt gta gat aca ttc 576 Phe Cys Asp Thr Thr Ala Leu Leu Ala Leu Ser Cys Val Asp Thr Phe 180 185 190 ggc aca gaa atg gtg agc ttt gtc tta gct gga ttc act ctt ctt agc 624 Gly Thr Glu Met Val Ser Phe Val Leu Ala Gly Phe Thr Leu Leu Ser 195 200 205 tct ctc ctt atc atc aca gtc act tat atc atc atc atc tca gcc atc 672 Ser Leu Leu Ile Ile Thr Val Thr Tyr Ile Ile Ile Ile Ser Ala Ile 210 215 220 ctg agg atc cag tca gca gca ggc agg cag aag gcc ttc tcc acc tgc 720 Leu Arg Ile Gln Ser Ala Ala Gly Arg Gln Lys Ala Phe Ser Thr Cys 225 230 235 240 gca tcc cac ctc atg gct gta act atc ttt tat ggg tct ctg att ttc 768 Ala Ser His Leu Met Ala Val Thr Ile Phe Tyr Gly Ser Leu Ile Phe 245 250 255 acc tat ttg caa cct gat aac aca tca tcg ctg acc cag gcg cag gtg 816 Thr Tyr Leu Gln Pro Asp Asn Thr Ser Ser Leu Thr Gln Ala Gln Val 260 265 270 gca tct gta ttc tat acg att gtc att ccc atg ctg aat cca ctc atc 864 Ala Ser Val Phe Tyr Thr Ile Val Ile Pro Met Leu Asn Pro Leu Ile 275 280 285 tac agt ctg agg aac aaa gat gtg aaa aat gct ctt ctg aga gtc ata 912 Tyr Ser Leu Arg Asn Lys Asp Val Lys Asn Ala Leu Leu Arg Val Ile 290 295 300 cat aga aaa ctt ttt cca tga 933 His Arg Lys Leu Phe Pro 305 310 <210> 468 <211> 310 <212> PRT <213> Homo sapiens <400> 468 Met Ala Gly Asn Asn Phe Thr Glu Val Thr Val Phe Ile Leu Ser Gly 1 5 10 15 Phe Ala Asn His Pro Glu Leu Gln Val Ser Leu Phe Leu Met Phe Leu 20 25 30 Phe Ile Tyr Leu Phe Thr Val Leu Gly Asn Leu Gly Leu Ile Thr Leu 35 40 45 Ile Arg Met Asp Ser Gln Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ala Phe Ile Asp Ile Phe Tyr Ser Ser Thr Val Thr Pro Lys 65 70 75 80 Ala Leu Val Asn Phe Gln Ser Asn Arg Arg Ser Ile Ser Phe Val Gly 85 90 95 Cys Phe Val Gln Met Tyr Phe Phe Val Gly Leu Val Cys Cys Glu Cys 100 105 110 Phe Leu Leu Gly Ser Met Ala Tyr Asn Arg Tyr Ile Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Ser Val Val Met Ser Gln Lys Val Ser Asn Trp Leu 130 135 140 Gly Val Met Pro Tyr Val Ile Gly Phe Thr Ser Ser Leu Ile Ser Val 145 150 155 160 Trp Val Ile Ser Ser Leu Ala Phe Cys Asp Ser Ser Ile Asn His Phe 165 170 175 Phe Cys Asp Thr Thr Ala Leu Leu Ala Leu Ser Cys Val Asp Thr Phe 180 185 190 Gly Thr Glu Met Val Ser Phe Val Leu Ala Gly Phe Thr Leu Leu Ser 195 200 205 Ser Leu Leu Ile Ile Thr Val Thr Tyr Ile Ile Ile Ile Ser Ala Ile 210 215 220 Leu Arg Ile Gln Ser Ala Ala Gly Arg Gln Lys Ala Phe Ser Thr Cys 225 230 235 240 Ala Ser His Leu Met Ala Val Thr Ile Phe Tyr Gly Ser Leu Ile Phe 245 250 255 Thr Tyr Leu Gln Pro Asp Asn Thr Ser Ser Leu Thr Gln Ala Gln Val 260 265 270 Ala Ser Val Phe Tyr Thr Ile Val Ile Pro Met Leu Asn Pro Leu Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Asp Val Lys Asn Ala Leu Leu Arg Val Ile 290 295 300 His Arg Lys Leu Phe Pro 305 310 <210> 469 <211> 864 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(864) <400> 469 atg gct ctg ttt atg cta ttt ctc ctg ata tac cta att act atg ctg 48 Met Ala Leu Phe Met Leu Phe Leu Leu Ile Tyr Leu Ile Thr Met Leu 1 5 10 15 ggg aat gtg ggg atg ata ttg ata atc cgc ctg gac ctc cag ctt cac 96 Gly Asn Val Gly Met Ile Leu Ile Ile Arg Leu Asp Leu Gln Leu His 20 25 30 act ccc atg tat ttt ttc ctt act cac ctg tca ttt att gac ctc agt 144 Thr Pro Met Tyr Phe Phe Leu Thr His Leu Ser Phe Ile Asp Leu Ser 35 40 45 tac tca act gtc gtc aca cct aaa acc tta gcg aac tta ctg act tcc 192 Tyr Ser Thr Val Val Thr Pro Lys Thr Leu Ala Asn Leu Leu Thr Ser 50 55 60 aac tat att tcc ttt acg ggc tgc ttt gcc cag atg ttc ttt ttt gcc 240 Asn Tyr Ile Ser Phe Thr Gly Cys Phe Ala Gln Met Phe Phe Phe Ala 65 70 75 80 ttc ttg ggt act gct gaa tgt tac ctt ctc tcc tca atg gcc cat gat 288 Phe Leu Gly Thr Ala Glu Cys Tyr Leu Leu Ser Ser Met Ala His Asp 85 90 95 cgc tat gca gcg atc tgc agt cct cta cac tac aca gtt att atg tcc 336 Arg Tyr Ala Ala Ile Cys Ser Pro Leu His Tyr Thr Val Ile Met Ser 100 105 110 aaa agg ctc tgc ctc gct ctc atc act ggg cct tat gtg att ggc ttt 384 Lys Arg Leu Cys Leu Ala Leu Ile Thr Gly Pro Tyr Val Ile Gly Phe 115 120 125 ata gac tcc ttt gtc aac gtg gtt tcc atg agc aga ttg cat ttc tac 432 Ile Asp Ser Phe Val Asn Val Val Ser Met Ser Arg Leu His Phe Tyr 130 135 140 gac tca aac gta att cat cac ttt ttc tgt gac act tcc cca att tta 480 Asp Ser Asn Val Ile His His Phe Phe Cys Asp Thr Ser Pro Ile Leu 145 150 155 160 gct ctg tcc tgc act gat aca tac aac acc gaa atc ctg ata ttc att 528 Ala Leu Ser Cys Thr Asp Thr Tyr Asn Thr Glu Ile Leu Ile Phe Ile 165 170 175 att gtt ggt tcc acc ctg atg gtg tcc ctt ttc aca ata tct gca tcc 576 Ile Val Gly Ser Thr Leu Met Val Ser Leu Phe Thr Ile Ser Ala Ser 180 185 190 tat gtg ttc att ctc ttt acc atc ctg aaa att aat tcc act tca gga 624 Tyr Val Phe Ile Leu Phe Thr Ile Leu Lys Ile Asn Ser Thr Ser Gly 195 200 205 aag cag aaa gct ttc tct act tgc gtc tct cat ctc ttg gga gtc acc 672 Lys Gln Lys Ala Phe Ser Thr Cys Val Ser His Leu Leu Gly Val Thr 210 215 220 atc ttt tat agc act ctg att ttt act tat tta aaa cca aga aag tct 720 Ile Phe Tyr Ser Thr Leu Ile Phe Thr Tyr Leu Lys Pro Arg Lys Ser 225 230 235 240 tat tcc ttg gga aga gat caa gtg gct tct gtt ttt tat act att gtg 768 Tyr Ser Leu Gly Arg Asp Gln Val Ala Ser Val Phe Tyr Thr Ile Val 245 250 255 att ccc gtg ctg aat cca ctc att tat agt ctt aga aac aaa gag gtg 816 Ile Pro Val Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Glu Val 260 265 270 aaa aat gct gtc atc aga gtc atg cag aga aga cag gac tcc agg taa 864 Lys Asn Ala Val Ile Arg Val Met Gln Arg Arg Gln Asp Ser Arg 275 280 285 <210> 470 <211> 287 <212> PRT <213> Homo sapiens <400> 470 Met Ala Leu Phe Met Leu Phe Leu Leu Ile Tyr Leu Ile Thr Met Leu 1 5 10 15 Gly Asn Val Gly Met Ile Leu Ile Ile Arg Leu Asp Leu Gln Leu His 20 25 30 Thr Pro Met Tyr Phe Phe Leu Thr His Leu Ser Phe Ile Asp Leu Ser 35 40 45 Tyr Ser Thr Val Val Thr Pro Lys Thr Leu Ala Asn Leu Leu Thr Ser 50 55 60 Asn Tyr Ile Ser Phe Thr Gly Cys Phe Ala Gln Met Phe Phe Phe Ala 65 70 75 80 Phe Leu Gly Thr Ala Glu Cys Tyr Leu Leu Ser Ser Met Ala His Asp 85 90 95 Arg Tyr Ala Ala Ile Cys Ser Pro Leu His Tyr Thr Val Ile Met Ser 100 105 110 Lys Arg Leu Cys Leu Ala Leu Ile Thr Gly Pro Tyr Val Ile Gly Phe 115 120 125 Ile Asp Ser Phe Val Asn Val Val Ser Met Ser Arg Leu His Phe Tyr 130 135 140 Asp Ser Asn Val Ile His His Phe Phe Cys Asp Thr Ser Pro Ile Leu 145 150 155 160 Ala Leu Ser Cys Thr Asp Thr Tyr Asn Thr Glu Ile Leu Ile Phe Ile 165 170 175 Ile Val Gly Ser Thr Leu Met Val Ser Leu Phe Thr Ile Ser Ala Ser 180 185 190 Tyr Val Phe Ile Leu Phe Thr Ile Leu Lys Ile Asn Ser Thr Ser Gly 195 200 205 Lys Gln Lys Ala Phe Ser Thr Cys Val Ser His Leu Leu Gly Val Thr 210 215 220 Ile Phe Tyr Ser Thr Leu Ile Phe Thr Tyr Leu Lys Pro Arg Lys Ser 225 230 235 240 Tyr Ser Leu Gly Arg Asp Gln Val Ala Ser Val Phe Tyr Thr Ile Val 245 250 255 Ile Pro Val Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Glu Val 260 265 270 Lys Asn Ala Val Ile Arg Val Met Gln Arg Arg Gln Asp Ser Arg 275 280 285 <210> 471 <211> 924 < 212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(924) <400> 471 atg gaa agc gag aac aga aca gtg ata aga gaa ttc atc ctc ctt ggt 48 Met Glu Ser Glu Asn Arg Thr Val Ile Arg Glu Phe Ile Leu Leu Gly 1 5 10 15 ctg acc cag tct caa gat att cag ctc ctg gtc ttt gtg cta gtt tta 96 Leu Thr Gln Ser Gln Asp Ile Gln Leu Leu Val Phe Val Leu Val Leu 20 25 30 ata ttc tac ttc atc atc ctc cct gga aat ttt ctc att att ttc acc 144 Ile Phe Tyr Phe Ile Ile Leu Pro Gly Asn Phe Leu Ile Ile Phe Thr 35 40 45 ata aag tca gac cct ggg ctc aca gcc ccc ctc tat ttc ttt ctg ggc 192 Ile Lys Ser Asp Pro Gly Leu Thr Ala Pro Leu Tyr Phe Phe Leu Gly 50 55 60 aac ttg gcc ttc ctg gat gca tcc tac tcc ttc act gtg gct ccc cgg 240 Asn Leu Ala Phe Leu Asp Ala Ser Tyr Ser Phe Thr Val Ala Pro Arg 65 70 75 80 atg ttg gtg gac ttc ctc tct gcg aag aag ata atc tcc tac aga ggc 288 Met Leu Val Asp Phe Leu Ser Ala Lys Lys Ile Ile Ser Tyr Arg Gly 85 90 95 tgc atc act cag ctc ttt ttc ttg cac ttc ctt gga gga ggg gag gga 336 Cys Ile Thr Gln Leu Phe Phe Leu His Phe Leu Gly Gly Gly Glu Gly 100 105 110 tta ctc ctt gtt gtg atg gcc ttt gac cgc tac atc gcc atc tgc cgg 384 Leu Leu Leu Val Val Met Ala Phe Asp Arg Tyr Ile Ala Ile Cys Arg 115 120 125 cct ctg cac tat cct act gtc atg aac cct aga acc tgc tat gca atg 432 Pro Leu His Tyr Pro Thr Val Met Asn Pro Arg Thr Cys Tyr Ala Met 130 135 140 atg ttg gct ctg tgg ctt ggg ggt ttt gtc cac tcc att atc cag gtg 480 Met Leu Ala Leu Trp Leu Gly Gly Phe Val His Ser Ile Ile Gln Val 145 150 155 160 gtc ctc atc ctc cgc ttg cct ttt tgt ggc cca aac cag ctg gac aac 528 Val Leu Ile Leu Arg Leu Pro Phe Cys Gly Pro Asn Gln Leu Asp Asn 165 170 175 ttc ttc tgt gat gtc cca cag gtc atc aag ctg gcc tgc acc gac aca 576 Phe Phe Cys Asp Val Pro Gln Val Ile Lys Leu Ala Cys Thr Asp Thr 180 185 190 ttt gtg gtg gag ctt ctg atg gtc ttc aac agt ggc ctg atg aca ctc 624 Phe Val Val Glu Leu Leu Met Val Phe Asn Ser Gly Leu Met Thr Leu 195 200 205 ctg tgc ttt ctg ggg ctt ctg gcc tcc tat gca gtc att ctt tgt cgc 672 Leu Cys Phe Leu Gly Leu Leu Ala Ser Tyr Ala Val Ile Leu Cys Arg 210 215 220 ata cga ggg tct tct tct gag gca aaa aac aag gcc atg tcc acg tgc 720 Ile Arg Gly Ser Ser Ser Glu Ala Lys Asn Lys Ala Met Ser Thr Cys 225 230 235 240 atc acc cat atc att gtt ata ttc ttc atg ttt gga cct ggc atc ttc 768 Ile Thr His Ile Ile Val Ile Phe Phe Met Phe Gly Pro Gly Ile Phe 245 250 255 atc tac acg cgc ccc ttc agg gct ttc cca gct gac aag gtg gtt tct 816 Ile Tyr Thr Arg Pro Phe Arg Ala Phe Pro Ala Asp Lys Val Val Ser 260 265 270 ctc ttc cac aca gtg att ttt cct ttg ttg aat cct gtc att tat acc 864 Leu Phe His Thr Val Ile Phe Pro Leu Leu Asn Pro Val Ile Tyr Thr 275 280 285 ctt cgc aac cag gaa gtg aaa gct tcc atg aaa aag gtg ttt aat aag 912 Leu Arg Asn Gln Glu Val Lys Ala Ser Met Lys Lys Val Phe Asn Lys 290 295 300 cac ata gcc tga 924 His Ile Ala 305 <210> 472 <211> 307 <212> PRT <213> Homo sapiens <400> 472 Met Glu Ser Glu Asn Arg Thr Val Ile Arg Glu Phe Ile Leu Leu Gly 1 5 10 15 Leu Thr Gln Ser Gln Asp Ile Gln Leu Leu Val Phe Val Leu Val Leu 20 25 30 I le Phe Tyr Phe Ile Ile Leu Pro Gly Asn Phe Leu Ile Ile Phe Thr 35 40 45 Ile Lys Ser Asp Pro Gly Leu Thr Ala Pro Leu Tyr Phe Phe Leu Gly 50 55 60 Asn Leu Ala Phe Leu Asp Ala Ser Tyr Ser Phe Thr Val Ala Pro Arg 65 70 75 80 Met Leu Val Asp Phe Leu Ser Ala Lys Lys Ile Ile Ser Tyr Arg Gly 85 90 95 Cys Ile Thr Gln Leu Phe Phe Leu His Phe Leu Gly Gly Gly Glu Gly 100 105 110 Leu Leu Leu Val Val Met Ala Phe Asp Arg Tyr Ile Ala Ile Cys Arg 115 120 125 Pro Leu His Tyr Pro Thr Val Met Asn Pro Arg Thr Cys Tyr Ala Met 130 135 140 Met Leu Ala Leu Trp Leu Gly Gly Phe Val His Ser Ile Ile Gln Val 145 150 155 160 Val Leu Ile Leu Arg Leu Pro Phe Cys Gly Pro Asn Gln Leu Asp Asn 165 170 175 Phe Phe Cys Asp Val Pro Gln Val Ile Lys Leu Ala Cys Thr Asp Thr 180 185 190 Phe Val Val Glu Leu Leu Met Val Phe Asn Ser Gly Leu Met Thr Leu 195 200 205 Leu Cys Phe Leu Gly Leu Leu Ala Ser Tyr Ala Val Ile Leu Cys Arg 210 215 220 Ile Arg Gly Ser Ser Ser Glu Ala Lys Asn Lys Ala Met Ser Thr Cys 225 230 235 240 Ile Thr His Ile Ile Val Ile Phe Phe Met Phe Gly Pro Gly Ile Phe 245 250 255 Ile Tyr Thr Arg Pro Phe Arg Ala Phe Pro Ala Asp Lys Val Val Ser 260 265 270 Leu Phe His Thr Val Ile Phe Pro Leu Leu Asn Pro Val Ile Tyr Thr 275 280 285 Leu Arg Asn Gln Glu Val Lys Ala Ser Met Lys Lys Val Phe Asn Lys 290 295 300 His Ile Ala 305 <210> 473 <211> 936 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(936) <400> 473 atg gct cac aca aat gaa tcg atg gtg tct gag ttt gta ctt ttg gga 48 Met Ala His Thr Asn Glu Ser Met Val Ser Glu Phe Val Leu Leu Gly 1 5 10 15 ctc tct aat tcc tgg gga ctt caa ctt ttc ttt ttt gcc atc ttc tct 96 Leu Ser Asn Ser Trp Gly Leu Gln Leu Phe Phe Phe Ala Ile Phe Ser 20 25 30 ata gtc tat gtg aca tca gtg cta ggc aat gtc tta att att gtc att 144 Ile Val Tyr Val Thr Ser Val Leu Gly Asn Val Leu Ile Ile Val Ile 35 40 45 att tct ttt gac tcc cat ttg aac tct cct atg tac ttc ttg ctc agt 192 Ile Ser Phe Asp Ser His Leu Asn Ser Pro Met Tyr Phe Leu Leu Ser 50 55 60 aat ctt tct ttc att gat atc tgt cag tct aac ttt gcc acc ccc aag 240 Asn Leu Ser Phe Ile Asp Ile Cys Gln Ser Asn Phe Ala Thr Pro Lys 65 70 75 80 atg ctt gta gac ttt ttt att gag cgc aag act atc tcc ttt gag ggt 288 Met Leu Val Asp Phe Phe Ile Glu Arg Lys Thr Ile Ser Phe Glu Gly 85 90 95 tgc atg gcc cag ata ttc gtt ctt cac agt ttt gtt ggg agt gag atg 336 Cys Met Ala Gln Ile Phe Val Leu His Ser Phe Val Gly Ser Glu Met 100 105 110 atg ttg ctt gta gct atg gca tat gac aga ttt ata gcc ata tgt aag 384 Met Leu Leu Val Ala Met Ala Tyr Asp Arg Phe Ile Ala Ile Cys Lys 115 120 125 cct ctg cac tac agt aca att atg aac cgg agg ctc tgt gta att ttt 432 Pro Leu His Tyr Ser Thr Ile Met Asn Arg Arg Leu Cys Val Ile Phe 130 135 140 gtg tct att tcc tgg gcg gtg ggc gtt ctt cat tct gtg agc cac ttg 480 Val Ser Ile Ser Trp Ala Val Gly Val Leu His Ser Val Ser His Leu 145 150 155 160 gct ttt aca gtg gac ctg cca ttc tgt ggt ccc aat gag gtg gat agc 528 Ala Phe Thr Val Asp Leu Pro Phe Cys Gly Pro Asn Glu Val Asp Ser 165 170 175 ttc ttt tgt gac ctt ccc ttg gtg ata gag ctg gct tgc atg gat aca 576 Phe Phe Cys Asp Leu Pro Leu Val Ile Glu Leu Ala Cys Met Asp Thr 180 185 190 tat gaa atg gaa att atg acc cta acg aac agt ggc ctg ata tca ttg 624 Tyr Glu Met Glu Ile Met Thr Leu Thr Asn Ser Gly Leu Ile Ser Leu 195 200 205 agc tgt ttc ctg gct tta att att tcc tac acc atc att ttg atc ggt 672 Ser Cys Phe Leu Ala Leu Ile Ile Ser Tyr Thr Ile Ile Leu Ile Gly 210 215 220 gtc cga tgc agg tcc tcc agt ggg tca tct aag gct ctt tct aca tta 720 Va l Arg Cys Arg Ser Ser Ser Gly Ser Ser Lys Ala Leu Ser Thr Leu 225 230 235 240 act gcc cac atc aca gtg gtc att ctt ttc ttc ggg cct tgc att tat 768 Thr Ala His Ile Thr Val Val Ile Leu Phe Phe Gly Pro Cys Ile Tyr 245 250 255 ttc tat ata tgg cct ttt agc aga ctt cct gtg gac aaa ttt ctt tct 816 Phe Tyr Ile Trp Pro Phe Ser Arg Leu Pro Val Asp Lys Phe Leu Ser 260 265 270 gtg ttc tac act gtt tgt act ccc ttg ttg aac ccc atc atc tac tct 864 Val Phe Tyr Thr Val Cys Thr Pro Leu Leu Asn Pro Ile Ile Tyr Ser 275 280 285 ctg agg aat gaa gat gtt aaa gca gcc atg tgg aag ctg aga aac cgt 912 Leu Arg Asn Glu Asp Val Lys Ala Ala Met Trp Lys Leu Arg Asn Arg 290 295 300 cat gtg aac tcc tgg aaa aac tag 936 His Val Asn Ser Trp Lys Asn 305 310 <210> 474 <211> 311 <212> PRT <213> Homo sapiens <400> 474 Met Ala His Thr Asn Glu Ser Met Val Ser Glu Phe Val Leu Leu Gly 1 5 10 15 Leu Ser Asn Ser Trp Gly Leu Gln Leu Phe Phe Phe Ala Ile Phe Ser 20 25 30 Ile Val Tyr Val Thr Ser Val Leu Gly Asn Val Leu Ile Ile Val Ile 35 40 45 Ile Ser Phe Asp Ser His Leu Asn Ser Pro Met Tyr Phe Leu Leu Ser 50 55 60 Asn Leu Ser Phe Ile Asp Ile Cys Gln Ser Asn Phe Ala Thr Pro Lys 65 70 75 80 Met Leu Val Asp Phe Phe Ile Glu Arg Lys Thr Ile Ser Phe Glu Gly 85 90 95 Cys Met Ala Gln Ile Phe Val Leu His Ser Phe Val Gly Ser Glu Met 100 105 110 Met Leu Leu Val Ala Met Ala Tyr Asp Arg Phe Ile Ala Ile Cys Lys 115 120 125 Pro Leu His Tyr Ser Thr Ile Met Asn Arg Arg Leu Cys Val Ile Phe 130 135 140 Val Ser Ile Ser Trp Ala Val Gly Val Leu His Ser Val Ser His Leu 145 150 155 160 Ala Phe Thr Val Asp Leu Pro Phe Cys Gly Pro Asn Glu Val Asp Ser 165 170 175 Phe Phe Cys Asp Leu Pro Leu Val Ile Glu Leu Ala Cys Met Asp Thr 180 185 190 Tyr Glu Met Glu Ile Met Thr Leu Thr Asn Ser Gly Leu Ile Ser Leu 195 200 205 Ser Cys Phe Leu Ala Leu Ile Ile Ser Tyr Thr Ile Ile Leu Ile Gly 210 215 220 Val Arg Cys Arg Ser Ser Ser Gly Ser Ser Lys Ala Leu Ser Thr Leu 225 230 235 240 Thr Ala His Ile Thr Val Val Ile Leu Phe Phe Gly Pro Cys Ile Tyr 245 250 255 Phe Tyr Ile Trp Pro Phe Ser Arg Leu Pro Val Asp Lys Phe Leu Ser 260 265 270 Val Phe Tyr Thr Val Cys Thr Pro Leu Leu Asn Pro Ile Ile Tyr Ser 275 280 285 Leu Arg Asn Glu Asp Val Lys Ala Ala Met Trp Lys Leu Arg Asn Arg 290 295 300 His Val Asn Ser Trp Lys Asn 305 310 <210> 475 <211> 978 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(978) <400> 475 atg cta gag tcc ttc cag aaa tca gag caa atg gcc tgg agc aat cag 48 Met Leu Glu Ser Phe Gln Lys Ser Glu Gln Met Ala Trp Ser Asn Gln 1 5 10 15 tct gcg gta acc gaa ttc ata cta cgg ggt ctg tcc agt tct tta gaa 96 Ser Ala Val Thr Glu Phe Ile Leu Arg Gly Leu Ser Ser Ser Leu Glu 20 25 30 ctc cag att ttc tac ttc ctg ttt ttc tcc ata gtc tat gca gcc act 144 Leu Gln Ile Phe Tyr Phe Leu Phe Phe Ser Ile Val Tyr Ala Ala Thr 35 40 45 gtg ctg ggg aac ctt ctt att gtg gtc acc att gca tca gag cca cac 192 Val Leu Gly Asn Leu Leu Ile Val Val Thr Ile Ala Ser Glu Pro His 50 55 60 ctt cat tcc cct acg tac ttt ctg ctg ggc aat ctc tcc ttc att gac 240 Leu His Ser Pro Thr Tyr Phe Leu Leu Gly Asn Leu Ser Phe Ile Asp 65 70 75 80 atg tcc ctg gcc tca ttt gcc acc ccc aaa atg att gca gac ttc ctt 288 Met Ser Leu Ala Ser Phe Ala Thr Pro Lys Met Ile Ala Asp Phe Leu 85 90 95 aga gaa cac aaa gcc atc tct ttt gaa ggc tgc atg acc cag atg ttc 336 Arg Glu His Lys Ala Ile Ser Phe Glu Gly Cys Met Thr Gln Met Phe 100 105 110 ttc cta cat ctc tta ggg ggt gct gag att gta ctg ctg atc tcc atg 384 Phe Leu His Leu Leu Gly Gly Ala Glu Ile Val Leu Leu Ile Ser Met 115 120 125 tcc ttt gat agg tac gtg gct atc tgt aag cct cta cat tac cta aca 432 Ser Phe Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu His Tyr Leu Thr 130 135 140 atc atg agc cga aga atg tgt gtt ggg ctt gtg ata ctt tcc tgg att 480 Ile Met Ser Arg Arg Met Cys Val Gly Leu Val Ile Leu Ser Trp Ile 145 150 155 160 gtc ggc atc ttc cat gct ctg agt cag tta gca ttt aca gtg aat ctg 528 Val Gly Ile Phe His Ala Leu Ser Gln Leu Ala Phe Thr Val Asn Leu 165 170 175 ccc ttc tgt gga ccc aat gaa gta gac agt ttc ttt tgt gac ctc cct 576 Pro Phe Cys Gly Pro Asn Glu Val Asp Ser Phe Phe Cys Asp Leu Pro 180 185 190 ttg gtg att aaa ctt gct tgt gtc gac aca tat att ctg ggg gtg ttc 624 Leu Val Ile Lys Leu Ala Cys Val Asp Thr Tyr Ile Leu Gly Val Phe 195 200 205 atg atc tca acc agt ggc atg att gcc ctg gtg tgc ttc atc ctc ttg 672 Met Ile Ser Thr Ser Gly Met Ile Ala Leu Val Cys Phe Ile Leu Leu 210 215 220 gtg atc tct tac act atc atc ctg gtc acc gtt cgg cag cgt tcc tct 720 Val Ile Ser Tyr Thr Ile Ile Leu Val Thr Val Arg Gln Arg Ser Ser 225 230 235 240 gg t gga tcc tcc aaa gcc ctc tcc acg tgc agt gcc cac ttt act gtt 768 Gly Gly Ser Ser Lys Ala Leu Ser Thr Cys Ser Ala His Phe Thr Val 245 250 255 gtg acc ctt ttc ttt ggc cca tgc act ttc att tat gtg tgg cct ttc 816 Val Thr Leu Phe Phe Gly Pro Cys Thr Phe Ile Tyr Val Trp Pro Phe 260 265 270 aca aat ttc cca ata gac aaa gta ctc tca gta ttt tat acc ata tac 864 Thr Asn Phe Pro Ile Asp Lys Val Leu Ser Val Phe Tyr Thr Ile Tyr 275 280 285 act ccc ctc ttg aat cca gtg atc tat acc gtt agg aat aaa gat gtc 912 Thr Pro Leu Leu Asn Pro Val Ile Tyr Thr Val Arg Asn Lys Asp Val 290 295 300 aag tat tcc atg agg aaa cta agc agc cat atc ttt aaa tct agg aag 960 Lys Tyr Ser Met Arg Lys Leu Ser Ser His Ile Phe Lys Ser Arg Lys 305 310 315 320 act gat cat act cct taa 978 Thr Asp His Thr Pro 325 <210> 476 <211> 325 <212> PRT <213> Homo sapiens <400> 476 Met Leu Glu Ser Phe Gln Lys Ser Glu Gln Met Ala Trp Ser Asn Gln 1 5 10 15 Ser Ala Val Thr Glu Phe Ile Leu Arg Gly Leu Ser Ser Ser Leu Glu 20 25 30 Leu Gln Ile Phe Tyr Phe Leu Phe Phe Ser Ile Val Tyr Ala Ala Thr 35 40 45 Val Leu Gly Asn Leu Leu Ile Val Val Thr Ile Ala Ser Glu Pro His 50 55 60 Leu His Ser Pro Thr Tyr Phe Leu Leu Gly Asn Leu Ser Phe Ile Asp 65 70 75 80 Met Ser Leu Ala Ser Phe Ala Thr Pro Lys Met Ile Ala Asp Phe Leu 85 90 95 Arg Glu His Lys Ala Ile Ser Phe Glu Gly Cys Met Thr Gln Met Phe 100 105 110 Phe Leu His Leu Leu Gly Gly Ala Glu Ile Val Leu Leu Ile Ser Met 115 120 125 Ser Phe Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu His Tyr Leu Thr 130 135 140 Ile Met Ser Arg Arg Met Cys Val Gly Leu Val Ile Leu Ser Trp Ile 145 150 155 160 Val Gly Ile Phe His Ala Leu Ser Gln Leu Ala Phe Thr Val Asn Leu 165 170 175 Pro Phe Cys Gly Pro Asn Glu Val Asp Ser Phe Phe Cys Asp Leu Pro 180 185 190 Leu Val Ile Lys Leu Ala Cys Val Asp Thr Tyr Ile Leu Gly Val Phe 195 200 205 Met Ile Ser Thr Ser Gly Met Ile Ala Leu Val Cys Phe Ile Leu Leu 210 215 220 Val Ile Ser Tyr Thr Ile Ile Leu Val Thr Val Arg Gln Arg Ser Ser 225 230 235 240 Gly Gly Ser Ser Lys Ala Leu Ser Thr Cys Ser Ala His Phe Thr Val 245 250 255 Val Thr Leu Phe Phe Gly Pro Cys Thr Phe Ile Tyr Val Trp Pro Phe 260 265 270 Thr Asn Phe Pro Ile Asp Lys Val Leu Ser Val Phe Tyr Thr Ile Tyr 275 280 285 Thr Pro Leu Leu Asn Pro Val Ile Tyr Thr Val Arg Asn Lys Asp Val 290 295 300 Lys Tyr Ser Met Arg Lys Leu Ser Ser His Ile Phe Lys Ser Arg Lys 305 310 315 320 T hr Asp His Thr Pro 325 <210> 477 <211> 945 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(945) <400> 477 atg gat gtg ggc aat aag tct acc atg tct gaa ttt gtt ttg ctg ggg 48 Met Asp Val Gly Asn Lys Ser Thr Met Ser Glu Phe Val Leu Leu Gly 1 5 10 15 ctc tct aat tcc tgg gaa cta cag atg ttt ttc ttt atg gtg ttt tca 96 Leu Ser Asn Ser Trp Glu Leu Gln Met Phe Phe Phe Met Val Phe Ser 20 25 30 ttg ctt tat gtg gca aca atg gtg ggt aac agc ctc ata gtc atc aca 144 Leu Leu Tyr Val Ala Thr Met Val Gly Asn Ser Leu Ile Val Ile Thr 35 40 45 gtt ata gtg gac cct cac cta cac tct cct atg tat ttc ctg ctt acc 192 Val Ile Val Asp Pro His Leu His Ser Pro Met Tyr Phe Leu Leu Thr 50 55 60 aat ctt tca atc att gat atg tct ctt gct tct ttc gcc acc cca aag 240 Asn Leu Ser Ile Ile Asp Met Ser Leu Ala Ser Phe Ala Thr Pro Lys 65 70 75 80 atg att aca gat tac cta aca ggt cac aaa acc atc tct ttt gat ggc 288 Met Ile Thr Asp Tyr Leu Thr Gly His Lys Thr Ile Ser Phe Asp Gly 85 90 95 tgc ctt acc cag ata ttc ttt ctc cac ctt ttc act gga act gag atc 336 Cys Leu Thr Gln Ile Phe Phe Leu His Leu Phe Thr Gly Thr Glu Ile 100 105 110 atc tta ctc atg gcc atg tcc ttt gat agg tat att gca ata tgc aag 384 Ile Leu Leu Met Ala Met Ser Phe Asp Arg Tyr Ile Ala Ile Cys Lys 115 120 125 ccc ctg cac tat gct tct gtc att agt ccc cag gtg tgt gtt gct ctc 432 Pro Leu His Tyr Ala Ser Val Ile Ser Pro Gln Val Cys Val Ala Leu 130 135 140 g tg gtg gct tcc tgg att atg gga gtt atg cat tca atg agt cag gtc 480 Val Val Ala Ser Trp Ile Met Gly Val Met His Ser Met Ser Gln Val 145 150 155 160 ata ttt gcc ctc acg tta cca ttc tgt ggt ccc tat gag gta gac agc 528 Ile Phe Ala Leu Thr Leu Pro Phe Cys Gly Pro Tyr Glu Val Asp Ser 165 170 175 ttt ttc tgt gac ctt cct gtg gtg ttc cag ttg gct tgt gtg gat act 576 Phe Phe Cys Asp Leu Pro Val Val Phe Gln Leu Ala Cys Val Asp Thr 180 185 190 tat gtt ctg ggc ctc ttt atg atc tca aca agt ggc ata att gcg ttg 624 Tyr Val Leu Gly Leu Phe Met Ile Ser Thr Ser Gly Ile Ile Ala Leu 195 200 205 tcc tgt ttt att gtt tta ttt aat tca tat gtt att gtc ctg gtt act 672 Ser Cys Phe Ile Val Leu Phe Asn Ser Tyr Val Ile Val Leu Val Thr 210 215 220 gtg aag cat cat tct tcc aga gga tca tct aag gcc ctt tct act tgt 720 Val Lys His His Ser Ser Arg Gly Ser Ser Lys Ala Leu Ser Thr Cys 225 230 235 240 aca gct cat ttc att gtt gtc ttc ttg ttc ttt ggg cca tgc atc ttc 768 Thr Ala His Phe Ile Val Val Phe Leu Phe Phe Gly Pro Cys Ile Phe 245 250 255 atc tac atg tgg cca cta agc agc ttt ctc aca gac aag att ctg tct 816 Ile Tyr Met Trp Pro Leu Ser Ser Phe Leu Thr Asp Lys Ile Leu Ser 260 265 270 gtg ttt tat acc atc ttt act ccc act ctg aac cca ata atc tat act 864 Val Phe Tyr Thr Ile Phe Thr Pro Thr Leu Asn Pro Ile Ile Tyr Thr 275 280 285 ttg agg aat caa gaa gta aag ata gcc atg agg aaa ctg aaa aat agg 912 Leu Arg Asn Gln Glu Val Lys Ile Ala Met Arg Lys Leu Lys Asn Arg 290 295 300 ttt cta aat ttt aat aag gca atg cct tca tag 945 Phe Leu Asn Phe Asn Lys Ala Met Pro Ser 305 310 315 <210> 478 <211> 314 <212> PRT <213> Homo sapiens <400> 478 Met Asp Val Gly Asn Lys Ser Thr Met Ser Glu Phe Val Leu Leu Gly 1 5 10 15 Leu Ser Asn Ser Trp Glu Leu Gln Met Phe Phe Phe Met Val Phe Ser 20 25 30 Leu Leu Tyr Val Ala Thr Met Val Gly Asn Ser Leu Ile Val Ile Thr 35 40 45 Val Ile Val Asp Pro His Leu His Ser Pro Met Tyr Phe Leu Leu Thr 50 55 60 Asn Leu Ser Ile Ile Asp Met Ser Leu Ala Ser Phe Ala Thr Pro Lys 65 70 75 80 Met Ile Thr Asp Tyr Leu Thr Gly His Lys Thr Ile Ser Phe Asp Gly 85 90 95 Cys Leu Thr Gln Ile Phe Phe Leu His Leu Phe Thr Gly Thr Glu Ile 100 105 110 Ile Leu Leu Met Ala Met Ser Phe Asp Arg Tyr Ile Ala Ile Cys Lys 115 120 125 Pro Leu His Tyr Ala Ser Val Ile Ser Pro Gln Val Cys Val Ala Leu 130 135 140 Val Val Ala Ser Trp Ile Met Gly Val Met His Ser Met Ser Gln Val 145 150 155 160 Ile Phe Ala Leu Thr Leu Pro Phe Cys Gly Pro Tyr Glu Val Asp Ser 165 170 175 Phe Phe Cys Asp Leu Pro Val Val Phe Gln Leu Ala Cys Val Asp Thr 180 185 190 Tyr Val Leu Gly Leu Phe Met Ile Ser Thr Ser Gly Ile Ile Ala Leu 195 200 205 Ser Cys Phe Ile Val Leu Phe Asn Ser Tyr Val Ile Val Leu Val Thr 210 215 220 Val Lys His His Ser Ser Arg Gly Ser Ser Lys Ala Leu Ser Thr Cys 225 230 235 240 Thr Ala His Phe Ile Val Val Phe Leu Phe Phe Gly Pro Cys Ile Phe 245 250 255 Ile Tyr Met Trp Pro Leu Ser Ser Phe Leu Thr Asp Lys Ile Leu Ser 260 265 270 Val Phe Tyr Thr Ile Phe Thr Pro Thr Leu Asn Pro Ile Ile Tyr Thr 275 280 285 Leu Arg Asn Gln Glu Val Lys Ile Ala Met Arg Lys Leu Lys Asn Arg 290 295 300 Phe Leu Asn Phe Asn Lys Ala Met Pro Ser 305 310 <210> 479 <211> 972 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(972) <400> 479 atg gat aag tcc aat tct tca gtg gtg tct gaa ttt gta ctg ttg gga 48 Met Asp Lys Ser Asn Ser Ser Val Val Ser Glu Phe Val Leu Leu Gly 1 5 10 15 ctc tgt agt tct caa aaa ctc cag ctt ttc tat ttt tgt ttc ttc tct 96 Leu Cys Ser Ser Gln Lys Leu Gln Leu Phe Tyr Phe Cys Phe Phe Ser 20 25 30 gtg ttg tat aca gtc att gtg ctg gga aat ctt ctc att atc ctc aca 144 Val Leu Tyr Thr Val Ile Val Leu Gly Asn Leu Leu Ile Ile Leu Thr 35 40 45 gtg act tct gat acc agc ctg cac tcc cct atg tac ttt ctc ttg gga 192 Val Thr Ser Asp Thr Ser Leu His Ser Pro Met Tyr Phe Leu Leu Gly 50 55 60 aac ctt tcc ttt gtt gac att tgt cag gct tct ttt gct acc cct aaa 240 Asn Leu Ser Phe Val Asp Ile Cys Gln Ala Ser Phe Ala Thr Pro Lys 65 70 75 80 atg att gca gat ttt ctg agt gca cac gag acc ata tct ttc agt ggc 288 Met Ile Ala Asp Phe Leu Ser Ala His Glu Thr Ile Ser Phe Ser Gly 85 90 95 tgc ata gcc caa att ttc ttt att cac ctt ttt act gga ggg gag atg 336 Cys Ile Ala Gln Ile Phe Phe Ile His Leu Phe Thr Gly Gly Glu Met 100 105 110 gtg cta ctt gtt tcg atg gcc tat gac agg tat gta gcc ata tgc aaa 384 Val Leu Leu Val Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys 115 120 125 ccc tta tac tat gtg gtc atc atg agc cga agg aca tgc act gtc ttg 432 Pro Leu Tyr Tyr Val Val Ile Met Ser Arg Arg Thr Cys Thr Val Leu 130 135 140 gta atg atc tcc tgg gct gtg agc ttg gtg cac aca tta agc cag tta 480 Val Met Ile Ser Trp Ala Val Ser Leu Val His Thr Leu Ser Gln Leu 145 150 155 160 tca ttt act gtg aac ctg cct ttt tgt gga cct aat gta gta gac agc 528 Ser Phe Thr Val Asn Leu Pro Phe Cys Gly Pro Asn Val Val Asp Ser 165 170 175 ttt ttt tgt gat ctt cct cga gtc acc aaa ctt gcc tgc ctg gac tct 576 Phe Phe Cys Asp Leu Pro Arg Val Thr Lys Leu Ala Cys Leu Asp Ser 180 185 190 tac atc att gaa ata cta att gtg gtc aat agt gga att ctt tcc cta 624 Tyr Ile Ile Glu Ile Leu Ile Val Val Asn Ser Gly Ile Leu Ser Leu 195 200 205 agc act ttc tct ctc ttg gtc agc tcc tac atc att att ctt gtt aca 672 Ser Thr Phe Ser Leu Leu Val Ser Ser Tyr Ile Ile Ile Leu Val Thr 210 215 220 gtt tgg ctc aag tct tca gct gca atg gca aag gca ttt tct acg ctg 720 Val Trp Leu Lys Ser Ser Ala Ala Met Ala Lys Ala Phe Ser Thr Leu 225 230 235 240 gct tcc cat att gca gta gta ata tta ttc ttt gga cct tgc atc ttc 768 Ala Ser His Ile Ala Val Val Ile Leu Phe Phe Gly Pro Cys Ile Phe 245 250 255 atc tat gtg tgg ccc ttt acc atc tct cct ttg gat aaa ttt ctt gcc 816 Ile Tyr Val Trp Pro Phe Thr Ile Ser Pro Leu Asp Lys Phe Leu Ala 260 265 270 ata ttt tac act gtt ttc acc ccc gtc cta aac ccc att att tat aca 864 Ile Phe Tyr Thr Val Phe Thr Pro Val Leu Asn Pro Ile Ile Tyr Thr 275 280 285 cta agg aat agg gat atg aag gct gcc gta agg aaa att gtg aac cat 912 Leu Arg Asn Arg Asp Met Lys Ala Ala Val Arg Lys Ile Val Asn His 290 295 300 tac ctg agg cca agg aga att tct gaa atg tca cta gta gtg aga act 960 Tyr Leu Arg Pro Arg Arg Ile Ser Glu Met Ser Leu Val Val Arg Thr 305 310 315 320 tcc ttt cat taa 972 Ser Phe His <210> 480 <211> 323 <212> PRT <213> Homo sapiens <400> 480 Met Asp Lys Ser Asn Ser Ser Val Val Ser Glu Phe Val Leu Leu Gly 1 5 10 15 Leu Cys Ser Ser Gln Lys Leu Gln Leu Phe Tyr Phe Cys Phe Phe Ser 20 25 30 Val Leu Tyr Thr Val Ile Val Leu Gly Asn Leu Leu Ile Ile Leu Thr 35 40 45 Val Thr Ser Asp Thr Ser Leu His Ser Pro Met Tyr Phe Leu Leu Gly 50 55 60 Asn Leu Ser Phe Val Asp Ile Cys Gln Ala Ser Phe Ala Thr Pro Lys 65 70 75 80 Met Ile Ala Asp Phe Leu Ser Ala His Glu Thr Ile Ser Phe Ser Gly 85 90 95 Cys Ile Ala Gln Ile Phe Phe Ile His Leu Phe Thr Gly Gly Glu Met 100 105 110 Val Leu Leu Val Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys 115 120 125 Pro Leu Tyr Tyr Val Val Ile Met Ser Arg Arg Thr Cys Thr Val Leu 130 135 140 Val Met Ile Ser Trp Ala Val Ser Leu Val His Thr Leu Ser Gln Leu 145 150 155 160 Ser Phe Thr Val Asn Leu Pro Phe Cys Gly Pro Asn Val Val Asp Ser 165 170 175 Phe Phe Cys Asp Leu Pro Arg Val Thr Lys Leu Ala Cys Leu Asp Ser 180 185 190 Tyr Ile Ile Glu Ile Leu Ile Val Val Asn Ser Gly Ile Leu Ser Leu 195 200 205 Ser Thr Phe Ser Leu Leu Val Ser Ser Tyr Ile Ile Ile Leu Val Thr 210 215 220 Val Trp Leu Lys Ser Ser Ala Ala Met Ala Lys Ala Phe Ser Thr Leu 225 230 235 240 Ala Ser His Ile Ala Val Val Ile Leu Phe Phe Gly Pro Cys Ile Phe 245 250 255 Ile Tyr Val Trp Pro Phe Thr Ile Ser Pro Leu Asp Lys Phe Leu Ala 260 265 270 Ile Phe Tyr Thr Val Phe Thr Pro Val Leu Asn Pro Ile Ile Tyr Thr 275 280 285 Leu Arg Asn Arg Asp Met Lys Ala Ala Val Arg Lys Ile Val Asn His 290 295 300 Tyr Leu Arg Pro Arg Arg Ile Ser Glu Met Ser Leu Val Val Arg Thr 305 310 315 320 Ser Phe His <210> 481 <211> 951 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(951) <400> 481 atg gtt gaa gaa aat cat acc atg aaa aat gag ttt atc ctc aca gga 48 Met Val Glu Glu Asn His Thr Met Lys Asn Glu Phe Ile Leu Thr Gly 1 5 10 15 ttt aca gat cac cct gag ctg aag act ctg ctg ttt gtg gtg ttc ttt 96 Phe Thr Asp His Pro Glu Leu Lys Thr Leu Leu Phe Val Val Phe Phe 20 25 30 gcc atc tat ctg atc acc gtg gtg ggg aat att agt ttg gtg gca ctg 144 Ala Ile Tyr Leu Ile Thr Val Val Gly Asn Ile Ser Leu Val Ala Leu 35 40 45 ata ttt aca cac cgt cgg ctt cac aca cca atg tac atc ttt ctg gga 192 Ile Phe Thr His Arg Arg Leu His Thr Pro Met Tyr Ile Phe Leu Gly 50 55 60 a at ctg gct ctt gtg gat tct tgc tgt gcc tgt gct att acc ccc aaa 240 Asn Leu Ala Leu Val Asp Ser Cys Cys Ala Cys Ala Ile Thr Pro Lys 65 70 75 80 atg tta gag aac ttc ttt tct gag ggc aaa agg att tcc ctc tat gaa 288 Met Leu Glu Asn Phe Phe Ser Glu Gly Lys Arg Ile Ser Leu Tyr Glu 85 90 95 tgt gca gta cag ttt tat ttt ctt tgc act gtg gaa act gca gac tgc 336 Cys Ala Val Gln Phe Tyr Phe Leu Cys Thr Val Glu Thr Ala Asp Cys 100 105 110 ttt ctt ctg gca gca gtg gcc tat gac cgc tat gtg gcc atc tgc aac 384 Phe Leu Leu Ala Ala Val Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 cca ctg cag tac cac atc atg atg tcc aag aaa ctc tgc att cag atg 432 Pro Leu Gln Tyr His Ile Met Met Ser Lys Lys Leu Cys Ile Gln Met 130 135 140 acc aca ggc gcc ttc ata gct gga aac ctg cat tcc atg att cat gta 480 Thr Thr Gly Ala Phe Ile Ala Gly Asn Leu His Ser Met Ile His Val 145 150 155 160 ggg ctt gta ttt agg tta gtt ttc tgt gga tcg aat cac atc aac cac 528 Gly Leu Val Phe Arg Leu Val Phe Cys Gly Ser Asn His Ile Asn His 165 170 175 ttt tac tgt gat att ctt ccc ttg tat aga ctc tcc tgt gtt gac cct 576 Phe Tyr Cys Asp Ile Leu Pro Leu Tyr Arg Leu Ser Cys Val Asp Pro 180 185 190 ttc atc aat gaa ctg gtt cta ttc atc ttc tca ggt tca gtt caa gtc 624 Phe Ile Asn Glu Leu Val Leu Phe Ile Phe Ser Gly Ser Val Gln Val 195 200 205 ttt acc ata ggt agt gtc tta ata tct tat ctc tat att ctt ctt act 672 Phe Thr Ile Gly Ser Val Leu Ile Ser Tyr Leu Tyr Ile Leu Leu Thr 210 215 220 att ttc aga atg aaa tcc aag gag gga agg gcc aaa gct ttt tct acc 720 Ile Phe Arg Met Lys Ser Lys Glu Gly Arg Ala Lys Ala Phe Ser Thr 225 230 235 240 tgt gca tcc cac ttt tca tca gtt tca tta ttc tat gga tct ctt ttc 768 Cys Ala Ser His Phe Ser Ser Val Ser Leu Phe Tyr Gly Ser Leu Phe 245 250 255 ttc cta tac att aga cca aat ttg ctt gaa gaa gga ggt aat gat ata 816 Phe Leu Tyr Ile Arg Pro Asn Leu Leu Glu Glu Gly Gly Asn Asp Ile 260 265 270 cca gct gct att tta ttt aca ata gta gtt ccc tta cta aat cct ttc 864 Pro Ala Ala Ile Leu Phe Thr Ile Val Val Pro Leu Leu Asn Pro Phe 275 280 285 att tat agc ctg aga aac aag gaa gta ata agt gtc tta aga aaa att 912 Ile Tyr Ser Leu Arg Asn Lys Glu Val Ile Ser Val Leu Arg Lys Ile 290 295 300 ctg ctg aaa ata aaa tct caa gga agt gtg aac aaa tga 951 Leu Leu Lys Ile Lys Ser Gln Gly Ser Val Asn Lys 305 310 315 <210> 482 <211> 316 <212> PRT <213> Homo sapiens <400> 482 Met Val Glu Glu Asn His Thr Met Lys Asn Glu Phe Ile Leu Thr Gly 1 5 10 15 Phe Thr Asp His Pro Glu Leu Lys Thr Leu Leu Phe Val Val Phe Phe 20 25 30 Ala Ile Tyr Leu Ile Thr Val Val Gly Asn Ile Ser Leu Val Ala Leu 35 40 45 Ile Phe Thr His Arg Arg Leu His Thr Pro Met Tyr Ile Phe Leu Gly 50 55 60 Asn Leu Ala Leu Val Asp Ser Cys Cys Ala Cys Ala Ile Thr Pro Lys 65 70 75 80 Met Leu Glu Asn Phe Phe Ser Glu Gly Lys Arg Ile Ser Leu Tyr Glu 85 90 95 Cys Ala Val Gln Phe Tyr Phe Leu Cys Thr Val Glu Thr Ala Asp Cys 100 105 110 Phe Leu Leu Ala Ala Val Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Gln Tyr His Ile Met Met Ser Lys Lys Leu Cys Ile Gln Met 130 135 140 Thr Thr Gly Ala Phe Ile Ala Gly Asn Leu His Ser Met Ile His Val 145 150 155 160 Gly Leu Val Phe Arg Leu Val Phe Cys Gly Ser Asn His Ile Asn His 165 170 175 Phe Tyr Cys Asp Ile Leu Pro Leu Tyr Arg Leu Ser Cys Val Asp Pro 180 185 190 Phe Ile Asn Glu Leu Val Leu Phe Ile Phe Ser Gly Ser Val Gln Val 195 200 205 Phe Thr Ile Gly Ser Val Leu Ile Ser Tyr Leu Tyr Ile Leu Leu Thr 210 215 220 Ile Phe Arg Met Lys Ser Lys Glu Gly Arg Ala Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Phe Ser Ser Val Ser Leu Phe Tyr Gly Ser Leu Phe 245 250 255 Phe Leu Tyr Ile Arg Pro Asn Leu Leu Glu Glu Gly Gly Asn Asp Ile 260 265 270 Pro Ala Ala Ile Leu Phe Thr Ile Val Val Pro Leu Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Val Ile Ser Val Leu Arg Lys Ile 290 295 300 Leu Leu Lys Ile Lys Ser Gln Gly Ser Val Asn Lys 305 310 315 <210> 483 <211> 954 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(954) <400> 483 atg cta agg aat ggc agc ata gtg acg gaa ttt atc ctc gtg ggc ttt 48 Met Leu Arg Asn Gly Ser Ile Val Thr Glu Phe Ile Leu Val Gly Phe 1 5 10 15 cag cag agc tcc act tcc aca cga gca ttg ctc ttt gcc ctc ttc ttg 96 Gln Gln Ser Ser Thr Ser Thr Arg Ala Leu Leu Phe Ala Leu Phe Leu 20 25 30 gcc ctc tac agc ctc acc atg gcc atg aat ggc ctc atc atc ttt atc 144 Ala Leu Tyr Ser Leu Thr Met Ala Met Asn Gly Leu Ile Ile Phe Ile 35 40 45 acc tcc tgg aca gac ccc aag ctc aac agc ccc atg tac ttc ttc ctc 192 Thr Ser Trp Thr Asp Pro Lys Leu Asn Ser Pro Met Tyr Phe Phe Leu 50 55 60 ggc cat ctg tct ctc ctg gat gtc tgc ttc atc acc act acc atc cca 240 Gly His Leu Ser Leu Leu Asp Val Cys Phe Ile Thr Thr Thr Ile Pro 65 70 75 80 cag atg ttg atc cac ctc gtg gtc agg gac cac att gtc tcc ttt gta 288 Gln Met Leu Ile His Leu Val Val Arg Asp His Ile Val Ser Phe Val 85 90 95 tgt tgc atg acc cag atg tac ttt gtc ttc tgt gtt ggt gtg gcc gag 336 Cys Cys Met Thr Gln Met Tyr Phe Val Phe Cys Val Gly Val Ala Glu 100 105 110 tgc atc ctc ttg gct ttc atg gcc tat gac cgt tat gtt gct atc tgc 384 Cys Ile Leu Leu Ala Phe Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys 115 120 125 tac cca ctt aac tat gtc ccg atc ata agc cag aag gtc tgt gtc agg 432 Tyr Pro Leu Asn Tyr Val Pro Ile Ile Ser Gln Lys Val Cys Val Arg 130 135 140 ctt gtg gga act gcc tgg ttc ttt ggg ctg atc aat ggc atc ttt ctc 480 Leu Val Gly Thr Ala Trp Phe Phe Gly Leu Ile Asn Gly Ile Phe Leu 145 150 155 160 gag tat att tca ttc cga gag ccc ttc cgc aga gac aac cac ata gaa 528 Glu Tyr Ile Ser Phe Arg Glu Pro Phe Arg Arg Asp Asn His Ile Glu 165 170 175 agc ttc ttc tgt gag gcc ccc ata gtg att ggc ctc tct tgt ggg gac 576 Ser Phe Phe Cys Glu Ala Pro Ile Val Ile Gly Leu Ser Cys Gly Asp 180 185 190 cct cag ttt agt ctg tgg gca atc ttt gcc gat gcc atc gtg gta att 624 Pro Gln Phe Ser Leu Trp Ala Ile Phe Ala Asp Ala Ile Val Val Ile 195 200 205 ctc agc ccc atg gtg ctc act gtc act tcc tat gtg cac atc ctg gcc 672 Leu Ser Pro Met Val Leu Thr Val Thr Ser Tyr Val His Ile Leu Ala 210 215 220 acc atc ctc agc aaa gcc tcc tcc tca ggt cgg ggg aag act ttc tct 720 Thr Ile Leu Ser Lys Ala Ser Ser Ser Gly Arg Gly Lys Thr Phe Ser 225 230 235 240 act tgt gcc tct cac ctg act gtg gtc atc ttt ctc tac act tca gct 768 Thr Cys Ala Ser His Leu Thr Val Val Ile Phe Leu Tyr Thr Ser Ala 245 250 255 atg ttc tct tac atg aac ccc cac agc aca cat ggg cct gac aaa gac 816 Met Phe Ser Tyr Met Asn Pro His Ser Thr His Gly Pro Asp Lys Asp 260 265 270 aaa cct ttc tcc ctc ctg tac acc atc att acc ccc atg tgc aac ccc 864 Lys Pro Phe Ser Leu Leu Tyr Thr Ile Ile Thr Pro Met Cys Asn Pro 275 280 285 atc att tat agt ttc cgc aac aag gaa att aag gag gcc atg gtg agg 912 Ile Ile Tyr Ser Phe Arg Asn Lys Glu Ile Lys Glu Ala Met Val Arg 290 295 300 gca ctt gga aga acc agg ctg gcc cag cca cag tct gtc tag 954 Ala Leu Gly Arg Thr Arg Leu Ala Gln Pro Gln Ser Val 305 310 315 <210> 484 <211> 317 <212> PRT <213> Homo sapiens <400> 484 Met Leu Arg Asn Gly Ser Ile Val Thr Glu Phe Ile Leu Val Gly Phe 1 5 10 15 G ln Gln Ser Ser Thr Ser Thr Arg Ala Leu Leu Phe Ala Leu Phe Leu 20 25 30 Ala Leu Tyr Ser Leu Thr Met Ala Met Asn Gly Leu Ile Ile Phe Ile 35 40 45 Thr Ser Trp Thr Asp Pro Lys Leu Asn Ser Pro Met Tyr Phe Phe Leu 50 55 60 Gly His Leu Ser Leu Leu Asp Val Cys Phe Ile Thr Thr Thr Ile Pro 65 70 75 80 Gln Met Leu Ile His Leu Val Val Arg Asp His Ile Val Ser Phe Val 85 90 95 Cys Cys Met Thr Gln Met Tyr Phe Val Phe Cys Val Gly Val Ala Glu 100 105 110 Cys Ile Leu Leu Ala Phe Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys 115 120 125 Tyr Pro Leu Asn Tyr Val Pro Ile Ile Ser Gln Lys Val Cys Val Arg 130 135 140 Leu Val Gly Thr Ala Trp Phe Phe Gly Leu Ile Asn Gly Ile Phe Leu 145 150 155 160 Glu Tyr Ile Ser Phe Arg Glu Pro Phe Arg Arg Asp Asn His Ile Glu 165 170 175 Ser Phe Phe Cys Glu Ala Pro Ile Val Ile Gly Leu Ser Cys Gly Asp 180 185 190 Pro Gln Phe Ser Leu Trp Ala Ile Phe Ala Asp Ala Ile Val Val Ile 195 200 205 Leu Ser Pro Met Val Leu Thr Val Thr Ser Tyr Val His Ile Leu Ala 210 215 220 Thr Ile Leu Ser Lys Ala Ser Ser Ser Gly Arg Gly Lys Thr Phe Ser 225 230 235 240 Thr Cys Ala Ser His Leu Thr Val Val Ile Phe Leu Tyr Thr Ser Ala 245 250 255 Met Phe Ser Tyr Met Asn Pro His Ser Thr His Gly Pro Asp Lys Asp 260 265 270 Lys Pro Phe Ser Leu Leu Tyr Thr Ile Ile Thr Pro Met Cys Asn Pro 275 280 285 Ile Ile Tyr Ser Phe Arg Asn Lys Glu Ile Lys Glu Ala Met Val Arg 290 295 300 Ala Leu Gly Arg Thr Arg Leu Ala Gln Pro Gln Ser Val 305 310 315 <210> 485 <211> 918 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(918) <400> 485 atg gtg act gaa ttc att ttt ctg ggt ctc tct gat tct cag gaa ctc 48 Met Val Thr Glu Phe Ile Phe Leu Gly Leu Ser Asp Ser Gln Glu Leu 1 5 10 15 cag acc ttc cta ttt atg ttg ttt ttt gta ttc tat gga gga atc gtg 96 Gln Thr Phe Leu Phe Met Leu Phe Phe Val Phe Tyr Gly Gly Ile Val 20 25 30 ttt gga aac ctt ctt att gtc ata aca gtg gta tct gac tcc cac ctt 144 Phe Gly Asn Leu Leu Ile Val Ile Thr Val Val Ser Asp Ser His Leu 35 40 45 cac tct ccc atg tac ttc ctg cta gcc aac ctc tca ctc att gat ctg 192 His Ser Pro Met Tyr Phe Leu Leu Ala Asn Leu Ser Leu Ile Asp Leu 50 55 60 tct ctg tct tca gtc aca gcc ccc aag atg att act gac ttt ttc agc 240 Ser Leu Ser Ser Val Thr Ala Pro Lys Met Ile Thr Asp Phe Phe Ser 65 70 75 80 cag cgc aaa gtc atc tct ttc aag ggc tgc ctt gtt cag ata ttt ctc 288 Gln Arg Lys Val Ile Ser Phe Lys Gly Cys Leu Val Gln Ile Phe Leu 85 90 95 ctt cac ttc ttt ggt ggg agt gag atg gtg atc ctc ata gcc atg ggc 336 Leu His Phe Phe Gly Gly Ser Glu Met Val Ile Leu Ile Ala Met Gly 100 105 110 ttt gac aga tat ata gca ata tgc aaa ccc cta cac tac act aca att 384 Phe Asp Arg Tyr Ile Ala Ile Cys Lys Pro Leu His Tyr Thr Thr Ile 115 120 125 atg tgt ggc aac gca tgt gtc ggc att atg gct gtc gca tgg gga att 432 Met Cys Gly Asn Ala Cys Val Gly Ile Met Ala Val Ala Trp Gly Ile 130 135 140 ggc ttt ctc cat tcg gtg agc cag ttg gcc ttt gcc gtg cac tta ccc 480 Gly Phe Leu His Ser Val Ser Gln Leu Ala Phe Ala Val His Leu Pro 145 150 155 160 ttc tgt ggt ccc aat gag gtc gat agt ttt tat tgt gac ctt cct agg 528 Phe Cys Gly Pro Asn Glu Val Asp Ser Phe Tyr Cys Asp Leu Pro Arg 165 170 175 gta atc aaa ctt gcc tgt aca gat acc tac agg cta gat att atg gtc 576 Val Ile Lys Leu Ala Cys Thr Asp Thr Tyr Arg Leu Asp Ile Met Val 180 185 190 att gct aac agt ggt gtg ctc act gtg tgt tct ttt gtt ctt cta atc 624 Ile Ala Asn Ser Gly Val Leu Thr Val Cys Ser Phe Val Leu Leu Ile 195 200 205 atc tca tac act atc atc cta atg acc atc cag cat tgc cct tta gat 672 Ile Ser Tyr Thr Ile Ile Leu Met Thr Ile Gln His Cys Pro Leu Asp 210 215 220 aag tcg tcc aaa gct ctg tcc act ttg act gct cac att aca gta gtt 720 Lys Ser Ser Lys Ala Leu Ser Thr Leu Thr Ala His Ile Thr Val Val 225 230 235 240 ctt ttg ttc ttt gga cca tgt gtc ttt att tat gcc tgg cca ttc ccc 768 Leu Leu Phe Phe Gly Pro Cys Val Phe Ile Tyr Ala Trp Pro Phe Pro 245 250 255 atc aag tca tta gat aaa ttc ctt gct gta ttt tat tct gtg atc acc 816 Ile Lys Ser Leu Asp Lys Phe Leu Ala Val Phe Tyr Ser Val Ile Thr 260 265 270 cct ctc ttg aac cca att ata tac aca ctg agg aac aaa gac atg aag 864 Pro Leu Leu Asn Pro Ile Ile Tyr Thr Leu Arg Asn Lys Asp Met Lys 275 280 285 acg gca ata aga cgg ctg aga aaa tgg gat gca cat tct agt gta aag 912 Thr Ala Ile Arg Arg Leu Arg Lys Trp Asp Ala His Ser Ser Val Lys 290 295 300 ttt tag 918 Phe 305 <210> 486 <211> 305 <212> PRT <213> Homo sapiens <400> 486 Met Val Thr Glu Phe Ile Phe Leu Gly Leu Ser Asp Ser Gln Glu Leu 1 5 10 15 Gln Thr Phe Leu Phe Met Leu Phe Phe Val Phe Tyr Gly Gly Ile Val 20 25 30 Phe Gly Asn Leu Leu Ile Val Ile Thr Val Val Ser Asp Ser His Leu 35 40 45 His Ser Pro Met Tyr Phe Leu Leu Ala Asn Leu Ser Leu Ile Asp Leu 50 55 60 Ser Leu Ser Ser Val Thr Ala Pro Lys Met Ile Thr Asp Phe Phe Ser 65 70 75 80 Gln Arg Lys Val Ile Ser Phe Lys Gly Cys Leu Val Gln Ile Phe Leu 85 90 95 Leu His Phe Phe Gly Gly Ser Glu Met Val Ile Leu Ile Ala Met Gly 100 105 110 Phe Asp Arg Tyr Ile Ala Ile Cys Lys Pro Leu His Tyr Thr Thr Ile 115 120 125 Met Cys Gly Asn Ala Cys Val Gly Ile Met Ala Val Ala Trp Gly Ile 130 135 140 Gly Phe Leu His Ser Val Ser Gln Leu Ala Phe Ala Val His Leu Pro 145 150 155 160 Phe Cys Gly Pro Asn Glu Val Asp Ser Phe Tyr Cys Asp Leu Pro Arg 165 170 175 Val Ile Lys Leu Ala Cys Thr Asp Thr Tyr Arg Leu Asp Ile Met Val 180 185 190 Ile Ala Asn Ser Gly Val Leu Thr Val Cys Ser Phe Val Leu Leu Ile 195 200 205 Ile Ser Tyr Thr Ile Ile Leu Met Thr Ile Gln His Cys Pro Leu Asp 210 215 220 Lys Ser Ser Lys Ala Leu Ser Thr Leu Thr Ala His Ile Thr Val Val 225 230 235 240 Leu Leu Phe Phe Gly Pro Cys Val Phe Ile Tyr Ala Trp Pro Phe Pro 245 250 255 Ile Lys Ser Leu Asp Lys Phe Leu Ala Val Phe Tyr Ser Val Ile Thr 260 265 270 Pro Leu Leu Asn Pro Ile Ile Tyr Thr Leu Arg Asn Lys Asp Met Lys 275 280 285 Thr Ala Ile Arg Arg Leu Arg Lys Trp Asp Ala His Ser Ser Val Lys 290 295 300 Phe 305 <210> 487 <211> 984 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(984) <400> 487 atg ctt cat acc aac aat aca cag ttt cac cct tcc acc ttc ctc gta 48 Met Leu His Thr Asn Asn Thr Gln Phe His Pro Ser Thr Phe Leu Val 1 5 10 15 gtg ggg gtc cca ggg ctg gaa gat gtg cat gta tgg att ggc ttc ccc 96 Val Gly Val Pro Gly Leu Glu Asp Val His Val Trp Ile Gly Phe Pro 20 25 30 ttc ttt gcg gtg tat cta aca gcc ctt cta ggg aac atc att atc ctg 144 Phe Phe Ala Val Tyr Leu Thr Ala Leu Leu Gly Asn Ile Ile Ile Leu 35 40 45 ttt gtg ata cag act gaa cag agc ctc cac caa ccc atg ttt tac ttc 192 Phe Val Ile Gln Thr Glu Gln Ser Leu His Gln Pro Met Phe Tyr Phe 50 55 60 cta gcc atg ttg gcc ggc act gat ctg ggc ttg tct aca gca acc atc 240 Leu Ala Met Leu Ala Gly Thr Asp Leu Gly Leu Ser Thr Ala Thr Ile 65 70 75 80 ccc aag atg ctg gga att ttc tgg ttt aat ctt gga gag att gca ttt 288 Pro Lys Met Leu Gly Ile Phe Trp Phe Asn Leu Gly Glu Ile Ala Phe 85 90 95 ggt gcc tgc atc aca cag atg tat acc att cat ata tgc act ggc ctg 336 Gly Ala Cys Ile Thr Gln Met Tyr Thr Ile His Ile Cys Thr Gly Leu 100 105 110 gag tct gtg gta ctg aca gtc acg ggc ata gat cgc tat att gcc atc 384 Glu Ser Val Val Leu Thr Val Thr Gly Ile Asp Arg Tyr Ile Ala Ile 115 120 125 tgc aac ccc ctg aga tat agc atg atc ctt acc aac aag gta ata gcc 432 Cys Asn Pro Leu Arg Tyr Ser Met Ile Leu Thr Asn Lys Val Ile Ala 130 135 140 att ctg ggc ata gtc atc att gtc agg act ttg gta ttt gtg act cca 480 Ile Leu Gly Ile Val Ile Ile Val Arg Thr Leu Val Phe Val Thr Pro 145 150 155 160 ttc aca ttt ctc acc ctg aga ttg cct ttc tgt ggt gtc cgg att atc 528 Phe Thr Phe Leu Thr Leu Arg Leu Pro Phe Cys Gly Val Arg Ile Ile 165 170 175 cct cat acc tat tgt gaa cac atg ggc ttg gca aag tta gct tgt gcc 576 Pro His Thr Tyr Cys Glu His Met Gly Leu Ala Lys Leu Ala Cys Ala 180 185 190 agt att aat gtt ata tat gga ttg att gcc ttc tca gtg gga tac att 624 Ser Ile Asn Val Ile Tyr Gly Leu Ile Ala Phe Ser Val Gly Tyr Ile 195 200 205 gac att tct gtg att gga ttt tcc tat gtc cag atc ctc cga gct gtc 672 Asp Ile Ser Val Ile Gly Phe Ser Tyr Val Gln Ile Leu Arg Ala Val 210 215 220 ttc cat ctc cca gcc tgg gat gcc cgg ctt aag gca ctc agc aca tgt 720 Phe His Leu Pro Ala Trp Asp Ala Arg Leu Lys Ala Leu Ser Thr Cys 225 230 235 240 ggc tct cac gtc tgt gtt atg ttg gct ttc tac ctg cca gcc ctc ttt 768 Gly Ser His Val Cys Val Met Leu Ala Phe Tyr Leu Pro Ala Leu Phe 245 250 255 tcc ttc atg aca cac cgc ttt ggc cac aac atc cct cat tac atc cac 816 Ser Phe Met Thr His Arg Phe Gly His Asn Ile Pro His Tyr Ile His 260 265 270 att ctt ctg gcc aat ctg tat gtg gtt ttt ccc cct gct ctt aac tct 864 Ile Leu Leu Ala Asn Leu Tyr Val Val Phe Pro Pro Ala Leu Asn Ser 275 280 285 gtt atc tat ggg gtc aaa aca aaa cag ata cga gag cag gta ctt agg 912 Val Ile Tyr Gly Val Lys Thr Lys Gln Ile Arg Glu Gln Val Leu Arg 290 295 300 ata ctc aac cct aaa agc ttt tgg cat ttt gac ccc aag agg atc ttc 960 Ile Leu Asn Pro Lys Ser Phe Trp His Phe Asp Pro Lys Arg Ile Phe 305 310 315 320 cac aac aat tca gtt aga caa taa 984 His Asn Asn Ser Val Arg Gln 325 <210> 488 <211> 327 <212> PRT <213> Homo sapiens <400> 488 Met Leu His Thr Asn Asn Thr Gln Phe His Pro Ser Thr Phe Leu Val 1 5 10 15 Val Gly Val Pro Gly Leu Glu Asp Val His Val Trp Ile Gly Phe Pro 20 25 30 Phe Phe Ala Val Tyr Leu Thr Ala Leu Leu Gly Asn Ile Ile Ile Leu 35 40 45 Phe Val Ile Gln Thr Glu Gln Ser Leu His Gln Pro Met Phe Tyr Phe 50 55 60 Leu Ala Met Leu Ala Gly Thr Asp Leu Gly Leu Ser Thr Ala Thr Ile 65 70 75 80 Pro Lys Met Leu Gly Ile Phe Trp Phe Asn Leu Gly Glu Ile Ala Phe 85 90 95 Gly Ala Cys Ile Thr Gln Met Tyr Thr Ile His Ile Cys Thr Gly Leu 100 105 110 Glu Ser Val Val Leu Thr Val Thr Gly Ile Asp Arg Tyr Ile Ala Ile 115 120 125 Cys Asn Pro Leu Arg Tyr Ser Met Ile Leu Thr Asn Lys Val Ile Ala 130 135 140 Ile Leu Gly Ile Val Ile Ile Val Arg Thr Leu Val Phe Val Thr Pro 145 150 155 160 Phe Thr Phe Leu Thr Leu Arg Leu Pro Phe Cys Gly Val Arg Ile Ile 165 170 175 Pro His Thr Tyr Cys Glu His Met Gly Leu Ala Lys Leu Ala Cys Ala 180 185 190 Ser Ile Asn Val Ile Tyr Gly Leu Ile Ala Phe Ser Val Gly Tyr Ile 195 200 205 Asp Ile Ser Val Ile Gly Phe Ser Tyr Val Gln Ile Leu Arg Ala Val 210 215 220 Phe His Leu Pro Ala Trp Asp Ala Arg Leu Lys Ala Leu Ser Thr Cys 225 230 235 240 Gly Ser His Val Cys Val Met Leu Ala Phe Tyr Leu Pro Ala Leu Phe 245 250 255 Ser Phe Met Thr His Arg Phe Gly His Asn Ile Pro His Tyr Ile His 260 265 270 Ile Leu Leu Ala Asn Leu Tyr Val Val Phe Pro Pro Ala Leu Asn Ser 275 280 285 Val Ile Tyr Gly Val Lys Thr Lys Gln Ile Arg Glu Gln Val Leu Arg 290 295 300 Ile Leu Asn Pro Lys Ser Phe Trp His Phe Asp Pro Lys Arg Ile Phe 305 310 315 320 His Asn Asn Ser Val Arg Gln 325 <210> 489 <211> 930 <2 12> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(930) <400> 489 atg gcg aat aga aac aat gtg aca gag ttt att cta ttg ggg ctt aca 48 Met Ala Asn Arg Asn Asn Val Thr Glu Phe Ile Leu Leu Gly Leu Thr 1 5 10 15 gag aat cca aaa atg cag aaa atc ata ttt gtt gtg ttt tct gtc atc 96 Glu Asn Pro Lys Met Gln Lys Ile Ile Phe Val Val Phe Ser Val Ile 20 25 30 tac atc aac gcc atg ata gga aat gtg ctc att gtg gtc acc atc act 144 Tyr Ile Asn Ala Met Ile Gly Asn Val Leu Ile Val Val Thr Ile Thr 35 40 45 gcc agc cca tca ctg aga tcc ccc atg tac ttt ttc ctg gcc tat ctc 192 Ala Ser Pro Ser Leu Arg Ser Pro Met Tyr Phe Phe Leu Ala Tyr Leu 50 55 60 tcc ttt att gat gcc tgc tat tcc tct gtc aat acc cct aag ctg atc 240 Ser Phe Ile Asp Ala Cys Tyr Ser Ser Val Asn Thr Pro Lys Leu Ile 65 70 75 80 aca gat tca ctc tat gaa aac aag act atc tta ttc aat gga tgt atg 288 Thr Asp Ser Leu Tyr Glu Asn Lys Thr Ile Leu Phe Asn Gly Cys Met 85 90 95 act caa gtc ttt gga gaa cat ttt ttc aga ggt gtt gag gtc atc cta 336 Thr Gln Val Phe Gly Glu His Phe Phe Arg Gly Val Glu Val Ile Leu 100 105 110 ctt act gta atg gcc tat gac cac tat gtg gcc atc tgc aag ccc ttg 384 Leu Thr Val Met Ala Tyr Asp His Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 cac tat acc acc atc atg aag cag cat gtt tgt agc ctg cta gtg gga 432 His Tyr Thr Thr Ile Met Lys Gln His Val Cys Ser Leu Leu Val Gly 130 135 140 gtg tca tgg gta gga ggc ttt ctt cat gca acc ata cag atc ctc ttc 480 Val Ser Trp Val Gly Gly Phe Leu His Ala Thr Ile Gln Ile Leu Phe 145 150 155 160 atc tgt caa tta cct ttc tgt ggt cct aat gtc ata gat cac ttt atg 528 Ile Cys Gln Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Phe Met 165 170 175 tgt gat ctc tac act ttg atc aat ctt gcc tgc act aat acc cac act 576 Cys Asp Leu Tyr Thr Leu Ile Asn Leu Ala Cys Thr Asn Thr His Thr 180 185 190 cta gga ctc ttc att gct gcc aac agt ggg ttc ata tgc ctg tta aac 624 Leu Gly Leu Phe Ile Ala Ala Asn Ser Gly Phe Ile Cys Leu Leu Asn 195 200 205 tgt ctc ttg ctc ctg gtc tcc tgc gtg gtc ata ctg tac tcc tta aag 672 Cys Leu Leu Leu Leu Val Ser Cys Val Val Ile Leu Tyr Ser Leu Lys 210 215 220 acc cac agc tta gag gca agg cat gaa gcc ctc tct acc tgt gtc tcc 720 Thr His Ser Leu Glu Ala Arg His Glu Ala Leu Ser Thr Cys Val Ser 225 230 235 240 cac atc aca gtt gtc atc tta tcc ttt ata ccc tgc ata ttt gtg tac 768 His Ile Thr Val Val Ile Leu Ser Phe Ile Pro Cys Ile Phe Val Tyr 245 250 255 atg aga cct cca gct act tta ccc att gat aaa gca gtt gct gta ttc 816 Met Arg Pro Pro Ala Thr Leu Pro Ile Asp Lys Ala Val Ala Val Phe 260 265 270 tac act atg ata act tct atg tta aac ccc tta atc tac acc ttg agg 864 Tyr Thr Met Ile Thr Ser Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 aat gct caa atg aaa aat gcc att agg aaa ttg tgt agt agg aaa gct 912 Asn Ala Gln Met Lys Asn Ala Ile Arg Lys Leu Cys Ser Arg Lys Ala 290 295 300 att tca agt gtc aaa taa 930 Ile Ser Ser Val Lys 305 310 <210> 490 <211> 309 <212> PRT <213> Homo sapiens <400> 490 Met Ala Asn Arg Asn Asn Val Thr Glu Phe Ile Leu Leu Gly Leu Thr 1 5 10 15 Glu Asn Pro Lys Met Gln Lys Ile Ile Phe Val Val Phe Ser Val Ile 20 25 30 Tyr Ile Asn Ala Met Ile Gly Asn Val Leu Ile Val Val Thr Ile Thr 35 40 45 Ala Ser Pro Ser Leu Arg Ser Pro Met Tyr Phe Phe Leu Ala Tyr Leu 50 55 60 Ser Phe Ile Asp Ala Cys Tyr Ser Ser Val Asn Thr Pro Lys Leu Ile 65 70 75 80 Thr Asp Ser Leu Tyr Glu Asn Lys Thr Ile Leu Phe Asn Gly Cys Met 85 90 95 Thr Gln Val Phe Gly Glu His Phe Phe Arg Gly Val Glu Val Ile Leu 100 105 110 Leu Thr Val Met Ala Tyr Asp His Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Thr Thr Ile Met Lys Gln His Val Cys Ser Leu Leu Val Gly 130 135 140 Val Ser Trp Val Gly Gly Phe Leu His Ala Thr Ile Gln Ile Leu Phe 145 150 155 160 Ile Cys Gln Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Phe Met 165 170 175 Cys Asp Leu Tyr Thr Leu Ile Asn Leu Ala Cys Thr Asn Thr His Thr 180 185 190 Leu Gly Leu Phe Ile Ala Ala Asn Ser Gly Phe Ile Cys Leu Leu Asn 195 200 205 Cys Leu Leu Leu Leu Val Ser Cys Val Val Ile Leu Tyr Ser Leu Lys 210 215 220 Thr His Ser Leu Glu Ala Arg His Glu Ala Leu Ser Thr Cys Val Ser 225 230 235 240 His Ile Thr Val Val Ile Leu Ser Phe Ile Pro Cys Ile Phe Val Tyr 245 250 255 Met Arg Pro Pro Ala Thr Leu Pro Ile Asp Lys Ala Val Ala Val Phe 260 265 270 Tyr Thr Met Ile Thr Ser Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ala Gln Met Lys Asn Ala Ile Arg Lys Leu Cys Ser Arg Lys Ala 290 295 300 Ile Ser Ser Val Lys 305 <210> 491 <211> 930 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(930) <400> 491 atg gag aag aaa aag aat gtg act gaa ttc att tta ata ggt ctt aca 48 Met Glu Lys Lys Lys Asn Val Thr Glu Phe Ile Leu Ile Gly Leu Thr 1 5 10 15 cag aac ccc ata atg gag aaa gtc acg ttt gta gta ttt ttg gtt ctt 96 Gln Asn Pro Ile Met Glu Lys Val Thr Phe Val Val Phe Leu Val Leu 20 25 30 tac atg ata aca ctt tca ggc aac ctg ctc att gtg gtt acc att acc 144 Tyr Met Ile Thr Leu Ser Gly Asn Leu Leu Ile Val Val Thr Ile Thr 35 40 45 acc agc cag gct ctg agc tcc ccc atg tac ttc ttc ctg acc cac ctt 192 Thr Ser Gln Ala Leu Ser Ser Pro Met Tyr Phe Phe Leu Thr His Leu 50 55 60 tct ttg ata gac aca gtt tat tct tct tct tca gct cct aag ttg att 240 Ser Leu Ile Asp Thr Val Tyr Ser Ser Ser Ser Ala Pro Lys Leu Ile 65 70 75 80 gtg gat tcc ttt caa gag aag aaa atc atc tcc ttt aat ggg tgt atg 288 Val Asp Ser Phe Gln Glu Lys Lys Ile Ile Ser Phe Asn Gly Cys Met 85 90 95 gct caa gcc tat gca gaa cac att ttt ggt gct act gag atc atc ctg 336 Ala Gln Ala Tyr Ala Glu His Ile Phe Gly Ala Thr Glu Ile Ile Leu 100 105 110 ctg aca gtg atg gcc tgt gac tgc tat gtg gcc atc tgc aaa cct ctg 384 Leu Thr Val Met Ala Cys Asp Cys Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 aac tac aca acc att atg agc cac agc ctg tgc att ctc ctg gtg gca 432 Asn Tyr Thr Thr Ile Met Ser His Ser Leu Cys Ile Leu Leu Val Ala 130 135 140 gtg gcc tgg gtg gga gga ttt ctt cat gca act att cag att ctc ttt 480 Val Ala Trp Val Gly Gly Phe Leu His Ala Thr Ile Gln Ile Leu Phe 145 150 155 160 aca gta tgg ctg ccc ttc tgt ggc ccc aat gtc ata ggc cac ttc atg 528 Thr Val Trp Leu Pro Phe Cys Gly Pro Asn Val Ile Gly His Phe Met 165 170 175 tgt gac ttg tac cca ttg tta aaa ctt gtt tgc ata gac act cat acc 576 Cys Asp Leu Tyr Pro Leu Leu Lys Leu Val Cys Ile Asp Thr His Thr 180 185 190 ctt ggt ctc ttt gtt gct gtg aac agt ggg ttt atc tgc tta tta aac 624 Leu Gly Leu Phe Val Ala Val Asn Ser Gly Phe Ile Cys Leu Leu Asn 195 200 205 ttc ctt atc ttg gtg gta tcc tat gtg atc atc ttg aga tct tta aag 672 Phe Leu Ile Leu Val Val Ser Tyr Val Ile Ile Leu Arg Ser Leu Lys 210 215 220 aac aat agc ttg gag ggg agg tgt aaa gcc ctc tcc acc tgt att tct 720 Asn Asn Ser Leu Glu Gly Arg Cys Lys Ala Leu Ser Thr Cys Ile Ser 225 230 235 240 cac atc ata gta gtt gtc tta ttc ttt gtg ccc tgt ata ttt gtg tat 768 His Ile Ile Val Val Val Leu Phe Phe Val Pro Cys Ile Phe Val Tyr 245 250 255 ctg cgc tca gtg acc act ctg ccc att gat aaa gct gtt gct gta ttt 816 Leu Arg Ser Val Thr Thr Leu Pro Ile Asp Lys Ala Val Ala Val Phe 260 265 270 tat act atg gtg gtc cca atg tta aat ccc gtg gtc tac aca ctc aga 864 Tyr Thr Met Val Val Pro Met Leu Asn Pro Val Val Tyr Thr Leu Arg 275 280 285 aat gct gag gta aaa agt gca ata agg aag ctt tgg aga aaa aaa gtg 912 Asn Ala Glu Val Lys Ser Ala Ile Arg Lys Leu Trp Arg Lys Lys Val 290 295 300 act tca gat aat gat taa 930 T hr Ser Asp Asn Asp 305 310 <210> 492 <211> 309 <212> PRT <213> Homo sapiens <400> 492 Met Glu Lys Lys Lys Asn Val Thr Glu Phe Ile Leu Ile Gly Leu Thr 1 5 10 15 Gln Asn Pro Ile Met Glu Lys Val Thr Phe Val Val Phe Leu Val Leu 20 25 30 Tyr Met Ile Thr Leu Ser Gly Asn Leu Leu Ile Val Val Thr Ile Thr 35 40 45 Thr Ser Gln Ala Leu Ser Ser Pro Met Tyr Phe Phe Leu Thr His Leu 50 55 60 Ser Leu Ile Asp Thr Val Tyr Ser Ser Ser Ser Ala Pro Lys Leu Ile 65 70 75 80 Val Asp Ser Phe Gln Glu Lys Lys Ile Ile Ser Phe Asn Gly Cys Met 85 90 95 Ala Gln Ala Tyr Ala Glu His Ile Phe Gly Ala Thr Glu Ile Ile Leu 100 105 110 Leu Thr Val Met Ala Cys Asp Cys Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 Asn Tyr Thr Thr Ile Met Ser His Ser Leu Cys Ile Leu Leu Val Ala 130 135 140 Val Ala Trp Val Gly Gly Phe Leu His Ala Thr Ile Gln Ile Leu Phe 145 150 155 160 Thr Val Trp Leu Pro Phe Cys Gly Pro Asn Val Ile Gly His Phe Met 165 170 175 Cys Asp Leu Tyr Pro Leu Leu Lys Leu Val Cys Ile Asp Thr His Thr 180 185 190 Leu Gly Leu Phe Val Ala Val Asn Ser Gly Phe Ile Cys Leu Leu Asn 195 200 205 Phe Leu Ile Leu Val Val Ser Tyr Val Ile Ile Leu Arg Ser Leu Lys 210 215 220 Asn Asn Ser Leu Glu Gly Arg Cys Lys Ala Leu Ser Thr Cys Ile Ser 225 230 235 240 His Ile Ile Val Val Val Leu Phe Phe Val Pro Cys Ile Phe Val Tyr 245 250 255 Leu Arg Ser Val Thr Thr Leu Pro Ile Asp Lys Ala Val Ala Val Phe 260 265 270 Tyr Thr Met Val Val Pro Met Leu Asn Pro Val Val Tyr Thr Leu Arg 275 280 285 Asn Ala Glu Val Lys Ser Ala Ile Arg Lys Leu Trp Arg Lys Lys Val 290 295 300 Thr Ser Asp Asn Asp 305 <210> 493 <211> 975 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(975) <400> 493 atg gag agc ccc aat caa acc acc att cag gag ttt atc ttc tcc gct 48 Met Glu Ser Pro Asn Gln Thr Thr Ile Gln Glu Phe Ile Phe Ser Ala 1 5 10 15 ttc cct tat tcc tgg gtt aag tct gtt gtc tgc ttt gtt cca ctg ctc 96 Phe Pro Tyr Ser Trp Val Lys Ser Val Val Cys Phe Val Pro Leu Leu 20 25 30 ttc atc tat gct ttc att gtt gtt gga aac ctg gtc atc atc aca gtg 144 Phe Ile Tyr Ala Phe Ile Val Val Gly Asn Leu Val Ile Ile Thr Val 35 40 45 gtc cag ttg aat act cac ctc cac act ccc atg tat act ttt atc agt 192 Val Gln Leu Asn Thr His Leu His Thr Pro Met Tyr Thr Phe Ile Ser 50 55 60 gct ctt tct ttt ctg gag att tgg tat acc aca gcc aca atc cca aag 240 Ala Leu Ser Phe Leu Glu Ile Trp Tyr Thr Thr Ala Thr Ile Pro Lys 65 70 75 80 atg ctg tct agc ctg ctt agt gag agg agc att tcc ttc aat ggt tgt 288 Met Leu Ser Ser Leu Leu Ser Glu Arg Ser Ile Ser Phe Asn Gly Cys 85 90 95 ctc ctg cag atg tat ttc ttc cat tcc acc ggc atc tgt gag gtg tgt 336 Leu Leu Gln Met Tyr Phe Phe His Ser Thr Gly Ile Cys Glu Val Cys 100 105 110 ctc ttg aca gtt atg gcc ttt gac cac tac ctg gcc ata tgc agc cct 384 Leu Leu Thr Val Met Ala Phe Asp His Tyr Leu Ala Ile Cys Ser Pro 115 120 125 ctt cat tat ccc tct atc atg acc ccc aag cta tgt acc caa ctg act 432 Leu His Tyr Pro Ser Ile Met Thr Pro Lys Leu Cys Thr Gln Leu Thr 130 135 140 tta agt tgc tgt gtt tgt ggc ttt atc aca ccc gtt cct gag att gcc 480 Leu Ser Cys Cys Val Cys Gly Phe Ile Thr Pro Val Pro Glu Ile Ala 145 150 155 160 tgg atc tct aca ctg cca ttt tgt ggt tcg aat cac ctt gaa cat atc 528 Trp Ile Ser Thr Leu Pro Phe Cys Gly Ser Asn His Leu Glu His Ile 165 170 175 ttc tgt gac ttc ctc cca gtg ctg cgt ctg gcc tgc aca gac aca cga 576 Phe Cys Asp Phe Leu Pro Val Leu Arg Leu Ala Cys Thr Asp Thr Arg 180 185 190 gcc atc gtc atg att cag gta gtg gat gtc att cat gca gtg gag att 624 Ala Ile Val Met Ile Gln Val Val Asp Val Ile His Ala Val Glu Ile 195 200 205 att aca gct gtg atg ctc atc ttc atg tcc tac gat ggt att gtg gct 672 Ile Thr Ala Val Met Leu Ile Phe Met Ser Tyr Asp Gly Ile Val Ala 210 215 220 gta att cta cgt att cat tca gct gga ggc cgc cgc aca gca ttt tcc 720 Val Ile Leu Arg Ile His Ser Ala Gly Gly Arg Arg Thr Ala Phe Ser 225 230 235 240 acg tgt gtc tct cac ttc att gtc ttt tcg ctc ttc ttt ggc agt gtg 768 Thr Cys Val Ser His Phe Ile Val Phe Ser Leu Phe Phe Gly Ser Val 245 250 255 act ctc atg tac cta cgc ttc tct gcc acc tac tct ttg ttc tgg gat 816 Thr Leu Met Tyr Leu Arg Phe Ser Ala Thr Tyr Ser Leu Phe Trp Asp 260 265 270 ata gcc att gct ctg gcc ttt gca gtt ttg tct ccc ttc ttc aac ccc 864 Ile Ala Ile Ala Leu Ala Phe Ala Val Leu Ser Pro Phe Phe Asn Pro 275 280 285 att atc tat agc ctg agg aat aaa gaa ata aaa gaa gct ata aaa aag 912 Ile Ile Tyr Ser Leu Arg Asn Lys Glu Ile Lys Glu Ala Ile Lys Lys 290 295 300 cac ata ggt caa gct aag ata ttt ttt tcc gta aga cca ggg acc tca 960 His Ile Gly Gln Ala Lys Ile Phe Phe Ser Val Arg Pro Gly Thr Ser 305 310 315 320 agt aag ata ttt tag 975 Ser Lys Ile Phe 325 <210> 494 <211> 324 <212> PRT <213> Homo sapiens <400> 494 Met Glu Ser Pro Asn Gln Thr Thr Ile Gln Glu Phe Ile Phe Ser Ala 1 5 10 15 Phe Pro Tyr Ser Trp Val Lys Ser Val Val Cys Phe Val Pro Leu Leu 20 25 30 Phe Ile Tyr Ala Phe Ile Val Val Gly Asn Leu Val Ile Ile Thr Val 35 40 45 Val Gln Leu Asn Thr His Leu His Thr Pro Met Tyr Thr Phe Ile Ser 50 55 60 Ala Leu Ser Phe Leu Glu Ile Trp Tyr Thr Thr Ala Thr Ile Pro Lys 65 70 75 80 Met Leu Ser Ser Leu Leu Ser Glu Arg Ser Ile Ser Phe Asn Gly Cys 85 90 95 Leu Leu Gln Met Tyr Phe Phe His Ser Thr Gly Ile Cys Glu Val Cys 100 105 110 Leu Leu Thr Val Met Ala Phe Asp His Tyr Leu Ala Ile Cys Ser Pro 115 120 125 Leu His Tyr Pro Ser Ile Met Thr Pro Lys Leu Cys Thr Gln Leu Thr 130 135 140 Leu Ser Cys Cys Val Cys Gly Phe Ile Thr Pro Val Pro Glu Ile Ala 145 150 155 160 Trp Ile Ser Thr Leu Pro Phe Cys Gly Ser Asn His Leu Glu His Ile 165 170 175 Phe Cys Asp Phe Leu Pro Val Leu Arg Leu Ala Cys Thr Asp Thr Arg 180 185 190 Ala Ile Val Met Ile Gln Val Val Asp Val Ile His Ala Val Glu Ile 195 200 205 Ile Thr Ala Val Met Leu Ile Phe Met Ser Tyr Asp Gly Ile Val Ala 210 215 220 Val Ile Leu Arg Ile His Ser Ala Gly Gly Arg Arg Thr Ala Phe Ser 225 230 235 240 Thr Cys Val Ser His Phe Ile Val Phe Ser Leu Phe Phe Gly Ser Val 245 250 255 Thr Leu Met Tyr Leu Arg Phe Ser Ala Thr Tyr Ser Leu Phe Trp Asp 260 265 270 Ile Ala Ile Ala Leu Ala Phe Ala Val Leu Ser Pro Phe Phe Asn Pro 275 280 285 Ile Ile Tyr Ser Leu Arg Asn Lys Glu Ile Lys Glu Ala Ile Lys Lys 290 295 300 His Ile Gly Gln Ala Lys Ile Phe Phe Ser Val Arg Pro Gly Thr Ser 305 310 315 320 Ser Lys Ile Phe <210> 495 <211> 1032 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1032) <400> 495 atg aag caa tat tca gtg ggt aat caa cat tcc aat tat agg agt ctc 48 Met Lys Gln Tyr Ser Val Gly Asn Gln His Ser Asn Tyr Arg Ser Leu 1 5 10 15 ttg ttt cct ttt ctg tgt tca cag atg aca cag ttg acg gcc agt ggg 96 Leu Phe Pro Phe Leu Cys Ser Gln Met Thr Gln Leu Thr Ala Ser Gly 20 25 30 aat cag aca atg gtg act gag ttc ctc ttc tct atg ttc ccg cat gcg 144 Asn Gln Thr Met Val Thr Glu Phe Leu Phe Ser Met Phe Pro His Ala 35 40 45 cac aga ggt ggc ctc tta ttc ttt att ccc ttg ctt ctc atc tac gga 192 His Arg Gly Gly Leu Leu Phe Phe Ile Pro Leu Leu Leu Ile Tyr Gly 50 55 60 ttt atc cta act gga aac cta ata atg ttc att gtc atc cag gtg ggc 240 Phe Ile Leu Thr Gly Asn Leu Ile Met Phe Ile Val Ile Gln Val Gly 65 70 75 80 atg gcc ctg cac acc cct ttg tat ttc ttt atc agt gtc ctc tcc ttc 288 Met Ala Leu His Thr Pro Leu Tyr Phe Phe Ile Ser Val Leu Ser Phe 85 90 95 ctg gag atc tgc tat acc aca acc acc atc ccc aag atg ctg tcc tgc 336 Leu Glu Ile Cys Tyr Thr Thr Thr Thr Ile Pro Lys Met Leu Ser Cys 100 105 110 cta atc agt gag cag aag agc att tcc gtg gct ggc tgc ctc ctg cag 384 Leu Ile Ser Glu Gln Lys Ser Ile Ser Val Ala Gly Cys Leu Leu Gln 115 120 125 atg tac ttt ttc cac tca ctt ggt atc aca gaa agc tgt gtc ctg aca 432 Met Tyr Phe Phe His Ser Leu Gly Ile Thr Glu Ser Cys Val Leu Thr 130 135 140 gca atg gcc att gac agg tac ata gct atc tgc aat cca ctc cgt tac 480 A la Met Ala Ile Asp Arg Tyr Ile Ala Ile Cys Asn Pro Leu Arg Tyr 145 150 155 160 cca acc atc atg att ccc aaa ctt tgt atc cag ctg aca gtt gga tcc 528 Pro Thr Ile Met Ile Pro Lys Leu Cys Ile Gln Leu Thr Val Gly Ser 165 170 175 tgc ttt tgt ggc ttc ctc ctt gtg ctt cct gag att gca tgg att tcc 576 Cys Phe Cys Gly Phe Leu Leu Val Leu Pro Glu Ile Ala Trp Ile Ser 180 185 190 acc ttg cct ttc tgt ggc tcc aac cag atc cac cag ata ttc tgt gat 624 Thr Leu Pro Phe Cys Gly Ser Asn Gln Ile His Gln Ile Phe Cys Asp 195 200 205 ttc aca cct gtg ctg agc ttg gcc tgc aca gat aca ttc cta gtg gtc 672 Phe Thr Pro Val Leu Ser Leu Ala Cys Thr Asp Thr Phe Leu Val Val 210 215 220 att gtg gat gcc atc cat gca gcg gaa att gta gcc tcc ttc ctg gtc 720 Ile Val Asp Ala Ile His Ala Ala Glu Ile Val Ala Ser Phe Leu Val 225 230 235 240 att gct cta tcc tac atc cgg att att ata gtg att ctg gga atg cac 768 Ile Ala Leu Ser Tyr Ile Arg Ile Ile Ile Val Ile Leu Gly Met His 245 250 255 tca gct gaa ggt cat cac aag gcc ttt tcc acc tgt gct gct cac ctt 816 Ser Ala Glu Gly His His Lys Ala Phe Ser Thr Cys Ala Ala His Leu 260 265 270 gct gtg ttc ttg cta ttt ttt ggc agt gtg gct gtc atg tat ttg aga 864 Ala Val Phe Leu Leu Phe Phe Gly Ser Val Ala Val Met Tyr Leu Arg 275 280 285 ttc tca gcc acc tac tca gtg ttt tgg gac aca gca att gct gtc act 912 Phe Ser Ala Thr Tyr Ser Val Phe Trp Asp Thr Ala Ile Ala Val Thr 290 295 300 ttt gtt atc ctt gct ccc ttt ttc aac ccc atc atc tat agc ctg aaa 960 Phe Val Ile Leu Ala Pro Phe Phe Asn Pro Ile Ile Tyr Ser Leu Lys 305 310 315 320 aac aag gac atg aaa gag gct att gga agg ctt ttc cac tat cag aag 1008 Asn Lys Asp Met Lys Glu Ala Ile Gly Arg Leu Phe His Tyr Gln Lys 325 330 335 agg gct ggt tgg gct ggg aaa tag 1032 Arg Ala Gly Trp Ala Gly Lys 340 <210> 496 <211> 343 <212> PRT <213> Homo sapiens <400> 496 Met Lys Gln Tyr Ser Val Gly Asn Gln His Ser Asn Tyr Arg Ser Leu 1 5 10 15 Leu Phe Pro Phe Leu Cys Ser Gln Met Thr Gln Leu Thr Ala Ser Gly 20 25 30 Asn Gln Thr Met Val Thr Glu Phe Leu Phe Ser Met Phe Pro His Ala 35 40 45 His Arg Gly Gly Leu Leu Phe Phe Ile Pro Leu Leu Leu Ile Tyr Gly 50 55 60 Phe Ile Leu Thr Gly Asn Leu Ile Met Phe Ile Val Ile Gln Val Gly 65 70 75 80 Met Ala Leu His Thr Pro Leu Tyr Phe Phe Ile Ser Val Leu Ser Phe 85 90 95 Leu Glu Ile Cys Tyr Thr Thr Thr Thr Ile Pro Lys Met Leu Ser Cys 100 105 110 Leu Ile Ser Glu Gln Lys Ser Ile Ser Val Ala Gly Cys Leu Leu Gln 115 120 125 Met Tyr Phe Phe His Ser Leu Gly Ile Thr Glu Ser Cys Val Leu Thr 130 135 140 Ala Met Ala Ile Asp Arg Tyr Ile Ala Ile Cys Asn Pro Leu Arg Tyr 145 150 155 160 Pro Thr Ile Met Ile Pro Lys Leu Cys Ile Gln Leu Thr Val Gly Ser 165 170 175 Cys Phe Cys Gly Phe Leu Leu Val Leu Pro Glu Ile Ala Trp Ile Ser 180 185 190 Thr Leu Pro Phe Cys Gly Ser Asn Gln Ile His Gln Ile Phe Cys Asp 195 200 205 Phe Thr Pro Val Leu Ser Leu Ala Cys Thr Asp Thr Phe Leu Val Val 210 215 220 Ile Val Asp Ala Ile His Ala Ala Glu Ile Val Ala Ser Phe Leu Val 225 230 235 240 Ile Ala Leu Ser Tyr Ile Arg Ile Ile Ile Val Ile Leu Gly Met His 245 250 255 Ser Ala Glu Gly His His Lys Ala Phe Ser Thr Cys Ala Ala His Leu 260 265 270 Ala Val Phe Leu Leu Phe Phe Gly Ser Val Ala Val Met Tyr Leu Arg 275 280 285 Phe Ser Ala Thr Tyr Ser Val Phe Trp Asp Thr Ala Ile Ala Val Thr 290 295 300 Phe Val Ile Leu Ala Pro Phe Phe Asn Pro Ile Ile Tyr Ser Leu Lys 305 310 315 320 Asn Lys Asp Met Lys Glu Ala Ile Gly Arg Leu Phe His Tyr Gln Lys 325 330 335 Arg Ala Gly Trp Ala Gly Lys 340 <210> 497 <211> 996 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(996) <400> 497 atg tgc tgg act atg ccc tct cca ttt aca ggt agc tct act aga aat 48 Met Cys Trp Thr Met Pro Ser Pro Phe Thr Gly Ser Ser Thr Arg Asn 1 5 10 15 atg gag agc aga aac caa tca aca gtg act gaa ttt atc ttc act gga 96 Met Glu Ser Arg Asn Gln Ser Thr Val Thr Glu Phe Ile Phe Thr Gly 20 25 30 ttc cct cag ctt cag gat ggt agt ctc ctg tac ttc ttt cct tta ctt 144 Phe Pro Gln Leu Gln Asp Gly Ser Leu Leu Tyr Phe Phe Pro Leu Leu 35 40 45 ttc atc tat act ttt att atc att gat aac tta tta atc ttc tct gct 192 Phe Ile Tyr Thr Phe Ile Ile Ile Asp Asn Leu Leu Ile Phe Ser Ala 50 55 60 gta agg ctg gac acc cat ctc cac aac ccc atg tat aat ttt atc agt 240 Val Arg Leu Asp Thr His Leu His Asn Pro Met Tyr Asn Phe Ile Ser 65 70 75 80 ata ttt tcc ttt ctg gag atc tgg tac acc aca gcc acc att ccc aag 288 Ile Phe Ser Phe Leu Glu Ile Trp Tyr Thr Thr Ala Thr Ile Pro Lys 85 90 95 atg ctc tcc aac ctc atc agt gaa aag aag gcc atc tca atg act ggc 336 Met Leu Ser Asn Leu Ile Ser Glu Lys Lys Ala Ile Ser Met Thr Gly 100 105 110 tgc atc ttg cag atg tat ttc ttc cac tca ctt gaa aac tca gag ggg 384 Cys Ile Leu Gln Met Tyr Phe Phe His Ser Leu Glu Asn Ser Glu Gly 115 120 125 atc ttg ctg acc acc atg gcc att gac aga tac gtt gcc atc tgc aac 432 Ile Leu Leu Thr Thr Met Ala Ile Asp Arg Tyr Val Ala Ile Cys Asn 130 135 140 cct ctt cgc tat caa atg atc atg acc ccc cgg ctc tgt gct cac ctc 480 Pro Leu Arg Tyr Gln Met Ile Met Thr Pro Arg Leu Cys Ala His Leu 145 150 155 160 tct gca ggt tcc tgc ctc ttc ggt ttc ctt atc ctg ctt ccc gag att 528 Ser Ala Gly Ser Cys Leu Phe Gly Phe Leu Ile Leu Leu Pro Glu Ile 165 170 175 gtg atg att tcc aca ctg cct ttc tgt ggg ccc aac caa atc cat cag 576 Val Met Ile Ser Thr Leu Pro Phe Cys Gly Pro Asn Gln Ile His Gln 180 185 190 atc ttc tgt gac ttg gtc cct gtg cta agc ctg gcc tgt aca gac acg 624 Ile Phe Cys Asp Leu Val Pro Val Leu Ser Leu Ala Cys Thr Asp Thr 195 200 205 tcc atg att ctg att gag gat gtg att cat gct gtg acc atc atc att 672 Ser Met Ile Leu Ile Glu Asp Val Ile His Ala Val Thr Ile Ile Ile 210 215 220 acc ttc cta atc att gcc ctg tcc tat gta aga att gtc act gtg ata 720 Thr Phe Leu Ile Ile Ala Leu Ser Tyr Val Arg Ile Val Thr Val Ile 225 230 235 240 ttg agg att ccc tct tct gaa ggg agg caa aag gct ttt tct acc tgt 768 Leu Arg Ile Pro Ser Ser Glu Gly Arg Gln Lys Ala Phe Ser Thr Cys 245 250 255 gca ggc cac ctc atg gtc ttc ctg ata ttc ttt ggc agt gta tca ctc 816 Ala Gly His Leu Met Val Phe Leu Ile Phe Phe Gly Ser Val Ser Leu 260 265 270 atg tac ttg cgt ttc agc aac act tat cca cca gtt ttg gac aca gcc 864 Met Tyr Leu Arg Phe Ser Asn Thr Tyr Pro Pro Val Leu Asp Thr Ala 275 280 285 att gca ctg atg ttt act gta ctt gct cca ttc ttc aat ccc atc att 912 Ile Ala Leu Met Phe Thr Val Leu Ala Pro Phe Phe Asn Pro Ile Ile 290 295 300 tat agc ctg aga aac aag gac atg aac aat gca att aaa aaa ctg ttc 960 Ty r Ser Leu Arg Asn Lys Asp Met Asn Asn Ala Ile Lys Lys Leu Phe 305 310 315 320 tgt ctt caa aaa gtg ttg aac aag cct gga ggt taa 996 Cys Leu Gln Lys Val Leu Asn Lys Pro Gly Gly 325 330 <210> 498 <211> 331 <212> PRT <213> Homo sapiens <400> 498 Met Cys Trp Thr Met Pro Ser Pro Phe Thr Gly Ser Ser Thr Arg Asn 1 5 10 15 Met Glu Ser Arg Asn Gln Ser Thr Val Thr Glu Phe Ile Phe Thr Gly 20 25 30 Phe Pro Gln Leu Gln Asp Gly Ser Leu Leu Tyr Phe Phe Pro Leu Leu 35 40 45 Phe Ile Tyr Thr Phe Ile Ile Ile Asp Asn Leu Leu Ile Phe Ser Ala 50 55 60 Val Arg Leu Asp Thr His Leu His Asn Pro Met Tyr Asn Phe Ile Ser 65 70 75 80 Ile Phe Ser Phe Leu Glu Ile Trp Tyr Thr Thr Ala Thr Ile Pro Lys 85 90 95 Met Leu Ser Asn Leu Ile Ser Glu Lys Lys Ala Ile Ser Met Thr Gly 100 105 110 Cys Ile Leu Gln Met Tyr Phe Phe His Ser Leu Glu Asn Ser Glu Gly 115 120 125 Ile Leu Leu Thr Thr Met Ala Ile Asp Arg Tyr Val Ala Ile Cys Asn 130 135 140 Pro Leu Arg Tyr Gln Met Ile Met Thr Pro Arg Leu Cys Ala His Leu 145 150 155 160 Ser Ala Gly Ser Cys Leu Phe Gly Phe Leu Ile Leu Leu Pro Glu Ile 165 170 175 Val Met Ile Ser Thr Leu Pro Phe Cys Gly Pro Asn Gln Ile His Gln 180 185 190 Ile Phe Cys Asp Leu Val Pro Val Leu Ser Leu Ala Cys Thr Asp Thr 195 200 205 Ser Met Ile Leu Ile Glu Asp Val Ile His Ala Val Thr Ile Ile Ile 210 215 220 Thr Phe Leu Ile Ile Ala Leu Ser Tyr Val Arg Ile Val Thr Val Ile 225 230 235 240 Leu Arg Ile Pro Ser Ser Glu Gly Arg Gln Lys Ala Phe Ser Thr Cys 245 250 255 Ala Gly His Leu Met Val Phe Leu Ile Phe Phe Gly Ser Val Ser Leu 260 265 270 Met Tyr Leu Arg Phe Ser Asn Thr Tyr Pro Pro Val Leu Asp Thr Ala 275 280 285 Ile Ala Leu Met Phe Thr Val Leu Ala Pro Phe Phe Asn Pro Ile Ile 290 295 300 Tyr Ser Leu Arg Asn Lys Asp Met Asn Asn Ala Ile Lys Lys Leu Phe 305 310 315 320 Cys Leu Gln Lys Val Leu Asn Lys Pro Gly Gly 325 330 <210> 499 <211> 954 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(954) <400> 499 atg gat caa tac aac cat tca agc ctg gct gaa ttt gtg ttc ctt ggc 48 Met Asp Gln Tyr Asn His Ser Ser Leu Ala Glu Phe Val Phe Leu Gly 1 5 10 15 ttt gcc agt gtg ggc tat gtc agg ggc tgg ctt ttt gtc ctg ctg cta 96 Phe Ala Ser Val Gly Tyr Val Arg Gly Trp Leu Phe Val Leu Leu Leu 20 25 30 ttg gca tac ctg ttc acc atc tgt ggt aac atg ctc atc ttc tca gtc 144 Leu Ala Tyr Leu Phe Thr Ile Cys Gly Asn Met Leu Ile Phe Ser Val 35 40 45 atc cga ctg gat gca gct ctg cac aca cct atg tac cac ttt gtc agt 192 Ile Arg Leu Asp Ala Ala Leu His Thr Pro Met Tyr His Phe Val Ser 50 55 60 gtt ctt tcc ttc ttg gag ttg tgg tat aca gct acc act atc cct aag 240 Val Leu Ser Phe Leu Glu Leu Trp Tyr Thr Ala Thr Thr Ile Pro Lys 65 70 75 80 atg ttg tct aat att ctc agt gag aag aaa acc att tct ttt gca gga 288 Met Leu Ser Asn Ile Leu Ser Glu Lys Lys Thr Ile Ser Phe Ala Gly 85 90 95 tgc ctc ctt cag acc tac ttc ttc cac tcc ttg gga gcg tct gaa tgc 336 Cys Leu Leu Gln Thr Tyr Phe Phe His Ser Leu Gly Ala Ser Glu Cys 100 105 110 tac ctt ctt aca gcc atg gcc tat gat aga tac ctg gcc att tgt cgg 384 Tyr Leu Leu Thr Ala Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys Arg 115 120 125 ccc ctc cac tac cct ata att atg acc acc aca ctc tgt gcc aag atg 432 Pro Leu His Tyr Pro Ile Ile Met Thr Thr Thr Leu Cys Ala Lys Met 130 135 140 gct gct gct tgt tgg act tgt ggc ttc ctg tgt ccc att tct gag gtc 480 Ala Ala Ala Cys Trp Thr Cys Gly Phe Leu Cys Pro Ile Ser Glu Val 145 150 155 160 atc ctt gcc tcc cag ctc cca ttt tgt gct tac aat gaa atc caa cac 528 Ile Leu Ala Ser Gln Leu Pro Phe Cys Ala Tyr Asn Glu Ile Gln His 165 170 175 att ttc tgt gac ttt cca cct ttg ctg agc ttg gcc tgc aag gac aca 576 Ile Phe Cys Asp Phe Pro Pro Leu Leu Ser Leu Ala Cys Lys Asp Thr 180 185 190 tct gct aac att ctg gtg gac ttt gcc att aat gct ttc ata att ctt 624 Ser Ala Asn Ile Leu Val Asp Phe Ala Ile Asn Ala Phe Ile Ile Leu 195 200 205 atc act ttc ttc ttt atc atg att tct tat gca agg atc att ggg gct 672 Ile Thr Phe Phe Phe Ile Met Ile Ser Tyr Ala Arg Ile Ile Gly Ala 210 215 220 gtg ctg aag ata aaa aca gca tca gga aga aag aag gcc ttt tct acc 720 Val Leu Lys Ile Lys Thr Ala Ser Gly Arg Lys Lys Ala Phe Ser Thr 225 230 235 240 tgt gcc tca cat ctt gct gtg gtc ctc atc ttc ttt ggg agc atc atc 768 Cys Ala Ser His Leu Ala Val Val Leu Ile Phe Phe Gly Ser Ile Ile 245 250 255 ttc atg tat gtg cgg cta aag aag agc tat tcc ctg acc ctt gac cga 816 Phe Met Tyr Val Arg Leu Lys Lys Ser Tyr Ser Leu Thr Leu Asp Arg 260 265 270 aca ctt gct ata gtt tac tcc gta cta aca cca atg gtc aat cca att 864 Thr Leu Ala Ile Val Tyr Ser Val Leu Thr Pro Met Val Asn Pro Ile 275 280 285 atc tac agt ctt cgt aac aag gaa atc att aaa gct atc aag agg acc 912 Ile Tyr Ser Leu Arg Asn Lys Glu Ile Ile Lys Ala Ile Lys Arg Thr 290 295 300 atc ttc cag aag gga gat aaa gct agt ctt gct cat ctt tga 954 Ile Phe Gln Lys Gly Asp Lys Ala Ser Leu Ala His Leu 305 310 315 <210> 500 <211> 317 <212> PRT <213> Homo sapiens <400> 500 Met Asp Gln Tyr Asn His Ser Ser Leu Ala Glu Phe Val Phe Leu Gly 1 5 10 15 Phe Ala Ser Val Gly Tyr Val Arg Gly Trp Leu Phe Val Leu Leu Leu 20 25 30 Leu Ala Tyr Leu Phe Thr Ile Cys Gly Asn Met Leu Ile Phe Ser Val 35 40 45 Ile Arg Leu Asp Ala Ala Leu His Thr Pro Met Tyr His Phe Val Ser 50 55 60 Val Leu Ser Phe Leu Glu Leu Trp Tyr Thr Ala Thr Thr Ile Pro Lys 65 70 75 80 Met Leu Ser Asn Ile Leu Ser Glu Lys Lys Thr Ile Ser Phe Ala Gly 85 90 95 Cys Leu Leu Gln Thr Tyr Phe Phe His Ser Leu Gly Ala Ser Glu Cys 100 105 110 Tyr Leu Leu Thr Ala Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys Arg 115 120 125 Pro Leu His Tyr Pro Ile Ile Met Thr Thr Thr Leu Cys Ala Lys Met 130 135 140 Ala Ala Ala Cys Trp Thr Cys Gly Phe Leu Cys Pro Ile Ser Glu Val 145 150 155 160 Ile Leu Ala Ser Gln Leu Pro Phe Cys Ala Tyr Asn Glu Ile Gln His 165 170 175 Ile Phe Cys Asp Phe Pro Pro Leu Leu Ser Leu Ala Cys Lys Asp Thr 180 185 190 Ser Ala Asn Ile Leu Val Asp Phe Ala Ile Asn Ala Phe Ile Ile Leu 195 200 205 Ile Thr Phe Phe Phe Ile Met Ile Ser Tyr Ala Arg Ile Ile Gly Ala 210 215 220 Val Leu Lys Ile Lys Thr Ala Ser Gly Arg Lys Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Ala Val Val Leu Ile Phe Phe Gly Ser Ile Ile 245 250 255 Phe Met Tyr Val Arg Leu Lys Lys Ser Tyr Ser Leu Thr Leu Asp Arg 260 265 270 Thr Leu Ala Ile Val Tyr Ser Val Leu Thr Pro Met Val Asn Pro Ile 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Ile Ile Lys Ala Ile Lys Arg Thr 290 295 300 Ile Phe Gln Lys Gly Asp Lys Ala Ser Leu Ala His Leu 305 310 315 <210> 501 <2 11> 801 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(801) <400> 501 atg tac tat ttc ctc agc cac ctg gcc ttt gtt gac ctt tgt tac tcc 48 Met Tyr Tyr Phe Leu Ser His Leu Ala Phe Val Asp Leu Cys Tyr Ser 1 5 10 15 tct gct att aca ccg aag atg atg gtg aat ttt gtt gtg gaa cgc aac 96 Ser Ala Ile Thr Pro Lys Met Met Val Asn Phe Val Val Glu Arg Asn 20 25 30 acc att cct ttc cat gct tgt gca acc caa ctg ggt tgt ttt ctc acc 144 Thr Ile Pro Phe His Ala Cys Ala Thr Gln Leu Gly Cys Phe Leu Thr 35 40 45 ttc atg atc act gag tgt ttc ctt cta gcc tcc atg gcc tac gat tgc 192 Phe Met Ile Thr Glu Cys Phe Leu Leu Ala Ser Met Ala Tyr Asp Cys 50 55 60 tat gtc gcc atc tgt agt ccc ctg cat tat tca aca ctg atg tca aga 240 Tyr Val Ala Ile Cys Ser Pro Leu His Tyr Ser Thr Leu Met Ser Arg 65 70 75 80 aga gtc tgc att caa ctg gtg gca gtt cca tat ata tac agc ttc ctg 288 Arg Val Cys Ile Gln Leu Val Ala Val Pro Tyr Ile Tyr Ser Phe Leu 85 90 95 gtt gcc ctc ttc cac acc gtt atc act ttc cgt ctg act tac tgt ggc 336 Val Ala Leu Phe His Thr Val Ile Thr Phe Arg Leu Thr Tyr Cys Gly 100 105 110 cca aac tta att aac cat ttc tat tgt gat gac ctc ccc ttc tta gct 384 Pro Asn Leu Ile Asn His Phe Tyr Cys Asp Asp Leu Pro Phe Leu Ala 115 120 125 ctg tcc tgc tca gac aca cac atg aag gaa att ctg ata ttt gcc ttt 432 Leu Ser Cys Ser Asp Thr His Met Lys Glu Ile Leu Ile Phe Ala Phe 130 135 140 gct ggc ttt gat atg atc tct tcc tct tcc att gtc ctc acc tcc tac 480 Ala Gly Phe Asp Met Ile Ser Ser Ser Ser Ile Val Leu Thr Ser Tyr 145 150 155 160 atc ttt att att gcc gct atc cta agg atc cgc tct act cag ggg caa 528 Ile Phe Ile Ile Ala Ala Ile Leu Arg Ile Arg Ser Thr Gln Gly Gln 165 170 175 cac aaa gcc att tcc acc tgt ggc tcc cat atg gtg act gtc act att 576 His Lys Ala Ile Ser Thr Cys Gly Ser His Met Val Thr Val Thr Ile 180 185 190 ttc tat ggc aca ctg atc ttt atg tac cta cag ccc aaa tca aat cac 624 Phe Tyr Gly Thr Leu Ile Phe Met Tyr Leu Gln Pro Lys Ser Asn His 195 200 205 tcc ttg gac aca gac aag atg gct tct gta ttt tac aca gtg gtg atc 672 Ser Leu Asp Thr Asp Lys Met Ala Ser Val Phe Tyr Thr Val Val Ile 210 215 220 ccc atg tta aac ccc cta atc tat agt cta agg aac aaa gaa gtg aaa 720 Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys 225 230 235 240 gat gcc tca aag aaa gcc ttg gat aaa ggt tgt gaa aac tta cag ata 768 Asp Ala Ser Lys Lys Ala Leu Asp Lys Gly Cys Glu Asn Leu Gln Ile 245 250 255 tta aca ttt tta aaa ata aga aaa ctt tat taa 801 Leu Thr Phe Leu Lys Ile Arg Lys Leu Tyr 260 265 <210> 502 <211> 266 <212> PRT <213> Homo sapiens <400> 502 Met Tyr Tyr Phe Leu Ser His Leu Ala Phe Val Asp Leu Cys Tyr Ser 1 5 10 15 Ser Ala Ile Thr Pro Lys Met Met Val Asn Phe Val Val Glu Arg Asn 20 25 30 Thr Ile Pro Phe His Ala Cys Ala Thr Gln Leu Gly Cys Phe Leu Thr 35 40 45 Phe Met Ile Thr Glu Cys Phe Leu Leu Ala Ser Met Ala Tyr Asp Cys 50 55 60 Tyr Val Ala Ile Cys Ser Pro Leu His Tyr Ser Thr Leu Met Ser Arg 65 70 75 80 Arg Val Cys Ile Gln Leu Val Ala Val Pro Tyr Ile Tyr Ser Phe Leu 85 90 95 Val Ala Leu Phe His Thr Val Ile Thr Phe Arg Leu Thr Tyr Cys Gly 100 105 110 Pro Asn Leu Ile Asn His Phe Tyr Cys Asp Asp Leu Pro Phe Leu Ala 115 120 125 Leu Ser Cys Ser Asp Thr His Met Lys Glu Ile Leu Ile Phe Ala Phe 130 135 140 Ala Gly Phe Asp Met Ile Ser Ser Ser Ser Ile Val Leu Thr Ser Tyr 145 150 155 160 Ile Phe Ile Ile Ala Ala Ile Leu Arg Ile Arg Ser Thr Gln Gly Gln 165 170 175 His Lys Ala Ile Ser Thr Cys Gly Ser His Met Val Thr Val Thr Ile 180 185 190 Phe Tyr Gly Thr Leu Ile Phe Met Tyr Leu Gln Pro Lys Ser Asn His 195 200 205 Ser Leu Asp Thr Asp Lys Met Ala Ser Val Phe Tyr Thr Val Val Ile 210 215 220 Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys 225 230 235 240 Asp Ala Ser Lys Lys Ala Leu Asp Lys Gly Cys Glu Asn Leu Gln Ile 245 250 255 Leu Thr Phe Leu Lys Ile Arg Lys Leu Tyr 260 265 <210> 503 <211> 768 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(768) <400> 503 atg tac ttt ttc ctg agc aac tta tcc ttt gtg gat ctg tgc ttc tct 48 M et Tyr Phe Phe Leu Ser Asn Leu Ser Phe Val Asp Leu Cys Phe Ser 1 5 10 15 tcc aat gtg act cca agg atg ctg gag att ttc ctt tca gag aag aaa 96 Ser Asn Val Thr Pro Arg Met Leu Glu Ile Phe Leu Ser Glu Lys Lys 20 25 30 agc att tcc tat cct gcc cgt ctt gtg cag tgt tac ctt ttt atc acc 144 Ser Ile Ser Tyr Pro Ala Arg Leu Val Gln Cys Tyr Leu Phe Ile Thr 35 40 45 ttg gtc cac gtt gag ctc tac atc ctg gct gtg atg gcc ttt gac cgg 192 Leu Val His Val Glu Leu Tyr Ile Leu Ala Val Met Ala Phe Asp Arg 50 55 60 tac atg gcc atc tgc aac cct ctg ctt tat ggc agc aga atg tcc aag 240 Tyr Met Ala Ile Cys Asn Pro Leu Leu Tyr Gly Ser Arg Met Ser Lys 65 70 75 80 agc gtg tgc tct ttc ctc atc aca gtg ctt tat gtg tat gga gca ctc 288 Ser Val Cys Ser Phe Leu Ile Thr Val Leu Tyr Val Tyr Gly Ala Leu 85 90 95 act ggc ctg atg gag act atg tgg acc tac aac cta gcc ttc tgt ggc 336 Thr Gly Leu Met Glu Thr Met Trp Thr Tyr Asn Leu Ala Phe Cys Gly 100 105 110 ccc agt gaa att aat cac ttc tac tgt gtg gac cca cca ctg att aag 384 Pro Ser Glu Ile Asn His Phe Tyr Cys Val Asp Pro Pro Leu Ile Lys 115 120 125 ctg gct tgt tct gac acc tac aac aag gag gtg tca atg ttt gtt gtg 432 Leu Ala Cys Ser Asp Thr Tyr Asn Lys Glu Val Ser Met Phe Val Val 130 135 140 gct ggt ttc aac ttc act tat cct ctc ctt atc atc ctc att tcc tat 480 Ala Gly Phe Asn Phe Thr Tyr Pro Leu Leu Ile Ile Leu Ile Ser Tyr 145 150 155 160 ctc tac ata ttt cct gcc acc cta agg atc tgc tct aca gaa ggc agg 528 Leu Tyr Ile Phe Pro Ala Thr Leu Arg Ile Cys Ser Thr Glu Gly Arg 165 170 175 cac aaa gct ttt tct acc tgt ggc tcc cat ctg aca gcc gtt act att 576 His Lys Ala Phe Ser Thr Cys Gly Ser His Leu Thr Ala Val Thr Ile 180 185 190 ttc tat tca gct ctt ttc ttc atg tat ctc aga cgt cca tca gaa gag 624 Phe Tyr Ser Ala Leu Phe Phe Met Tyr Leu Arg Arg Pro Ser Glu Glu 195 200 205 tcc atg gag cag ggg aaa atg gta gct gta ttt tat acc act gta atc 672 Ser Met Glu Gln Gly Lys Met Val Ala Val Phe Tyr Thr Thr Val Ile 210 215 220 ccc atg ttg aat ccc atg atc tac agt ctg agg aac aaa gat gtg aaa 720 Pro Met Leu Asn Pro Met Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys 225 230 235 240 gag gca tta tgc aaa gaa ctg ttc aaa aga aaa ttg ttt tct aaa taa 768 Glu Ala Leu Cys Lys Glu Leu Phe Lys Arg Lys Leu Phe Ser Lys 245 250 255 <210> 504 <211> 255 <212> PRT <213> Homo sapiens <400> 504 Met Tyr Phe Phe Leu Ser Asn Leu Ser Phe Val Asp Leu Cys Phe Ser 1 5 10 15 Ser Asn Val Thr Pro Arg Met Leu Glu Ile Phe Leu Ser Glu Lys Lys 20 25 30 Ser Ile Ser Tyr Pro Ala Arg Leu Val Gln Cys Tyr Leu Phe Ile Thr 35 40 45 Leu Val His Val Glu Leu Tyr Ile Leu Ala Val Met Ala Phe Asp Arg 50 55 60 Tyr Met Ala Ile Cys Asn Pro Leu Leu Tyr Gly Ser Arg Met Ser Lys 65 70 75 80 Ser Val Cys Ser Phe Leu Ile Thr Val Leu Tyr Val Tyr Gly Ala Leu 85 90 95 Thr Gly Leu Met Glu Thr Met Trp Thr Tyr Asn Leu Ala Phe Cys Gly 100 105 110 Pro Ser Glu Ile Asn His Phe Tyr Cys Val Asp Pro Pro Leu Ile Lys 115 120 125 Leu Ala Cys Ser Asp Thr Tyr Asn Lys Glu Val Ser Met Phe Val Val 130 135 140 Ala Gly Phe Asn Phe Thr Tyr Pro Leu Leu Ile Ile Leu Ile Ser Tyr 145 150 155 160 Leu Tyr Ile Phe Pro Ala Thr Leu Arg Ile Cys Ser Thr Glu Gly Arg 165 170 175 His Lys Ala Phe Ser Thr Cys Gly Ser His Leu Thr Ala Val Thr Ile 180 185 190 Phe Tyr Ser Ala Leu Phe Phe Met Tyr Leu Arg Arg Pro Ser Glu Glu 195 200 205 Ser Met Glu Gln Gly Lys Met Val Ala Val Phe Tyr Thr Thr Val Ile 210 215 220 Pro Met Leu Asn Pro Met Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys 225 230 235 240 Glu Ala Leu Cys Lys Glu Leu Phe Lys Arg Lys Leu Phe Ser Lys 245 250 255 <210> 505 <211> 813 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(813) <400> 505 atg ggc ctt ggg ggg aat tac ctg ggg ggt ttg ggg ggn nnn nnn nnn 48 Met Gly Leu Gly Gly Asn Tyr Leu Gly Gly Leu Gly Xaa Xaa Xaa Xaa 1 5 10 15 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 96 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 20 25 30 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn tcc att 144 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ser Ile 35 40 45 cta gga tgt gcc ttc cag cta ctt tta atg act tcc ttc tca gca gga 192 Leu Gly Cys Ala Phe Gln Leu Leu Leu Met Thr Ser Phe Ser Ala Gly 50 55 60 gag ata ttt atc ctc act gcc atg tcc tat gac cgc tat gta gcc atc 240 Glu Ile Phe Ile Leu Thr Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile 65 70 75 80 tgc tgt ccc ctg aac tac gag gta atc atg aat act gga gtc tgt gtg 288 Cys Cys Pro Leu Asn Tyr Glu Val Ile Met Asn Thr Gly Val Cys Val 85 90 95 tta atg gca agt gtt tcc tgg gcc att gga ggg ctc ttt ggt act gcg 336 Leu Met Ala Ser Val Ser Trp Ala Ile Gly Gly Leu Phe Gly Thr Ala 100 105 110 tac aca gct ggc aca ttt tcc atg cct ttc tgt ggc tcc agt gtg att 384 Tyr Thr Ala Gly Thr Phe Ser Met Pro Phe Cys Gly Ser Ser Val Ile 115 120 125 cca cag ttt ttc tgt gat gtt cct tca tta cta agg att tcc tgt tct 432 Pro Gln Phe Phe Cys Asp Val Pro Ser Leu Leu Arg Ile Ser Cys Ser 130 135 140 gaa aca cta atg gta att tat gca ggt att gga gtt ggt gca tgt tta 480 Glu Thr Leu Met Val Ile Tyr Ala Gly Ile Gly Val Gly Ala Cys Leu 145 150 155 160 agc att tct tgt ttc atc tgt att gtg atc tct tac att tat atc ttc 528 Ser Ile Ser Cys Phe Ile Cys Ile Val Ile Ser Tyr Ile Tyr Ile Phe 165 170 175 tcc act gta ctg aag atc cct acc act aaa ggt cag tcc aaa gct ttt 576 Ser Thr Val Leu Lys Ile Pro Thr Thr Lys Gly Gln Ser Lys Ala Phe 180 185 190 t cc aca tgc ttc ccc cat ctc act gtt ttc act gtt ttt atc ata act 624 Ser Thr Cys Phe Pro His Leu Thr Val Phe Thr Val Phe Ile Ile Thr 195 200 205 gct tat ttt gtt tat ctt aag cca cct tca aat tca cca tct gtt att 672 Ala Tyr Phe Val Tyr Leu Lys Pro Pro Ser Asn Ser Pro Ser Val Ile 210 215 220 gac agg ctg ctt tct gtg atc tac act gtg atg cct cca gta ttt aac 720 Asp Arg Leu Leu Ser Val Ile Tyr Thr Val Met Pro Pro Val Phe Asn 225 230 235 240 cct gta acc tac agc ctg cgg aac aat gac atg aaa tgt gct ctg ata 768 Pro Val Thr Tyr Ser Leu Arg Asn Asn Asp Met Lys Cys Ala Leu Ile 245 250 255 agg ttg ctg cag aaa aca tat ggt cag gag gct tac ttc att taa 813 Arg Leu Leu Gln Lys Thr Tyr Gly Gln Glu Ala Tyr Phe Ile 260 265 270 <210> 506 <211> 270 <212> PRT <213> Homo sapiens <400> 506 Met Gly Leu Gly Gly Asn Tyr Leu Gly Gly Leu Gly Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 20 25 30 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ser Ile 35 40 45 Leu Gly Cys Ala Phe Gln Leu Leu Leu Met Thr Ser Phe Ser Ala Gly 50 55 60 Glu Ile Phe Ile Leu Thr Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile 65 70 75 80 Cys Cys Pro Leu Asn Tyr Glu Val Ile Met Asn Thr Gly Val Cys Val 85 90 95 Leu Met Ala Ser Val Ser Trp Ala Ile Gly Gly Leu Phe Gly Thr Ala 100 105 110 Tyr Thr Ala Gly Thr Phe Ser Met Pro Phe Cys Gly Ser Ser Val Ile 115 120 125 Pro Gln Phe Phe Cys Asp Val Pro Ser Leu Leu Arg Ile Ser Cys Ser 130 135 140 Glu Thr Leu Met Val Ile Tyr Ala Gly Ile Gly Val Gly Ala Cys Leu 145 150 155 160 Ser Ile Ser Cys Phe Ile Cys Ile Val Ile Ser Tyr Ile Tyr Ile Phe 165 170 175 Ser Thr Val Leu Lys Ile Pro Thr Thr Lys Gly Gln Ser Lys Ala Phe 180 185 190 Ser Thr Cys Phe Pro His Leu Thr Val Phe Thr Val Phe Ile Ile Thr 195 200 205 Ala Tyr Phe Val Tyr Leu Lys Pro Pro Ser Asn Ser Pro Ser Val Ile 210 215 220 Asp Arg Leu Leu Ser Val Ile Tyr Thr Val Met Pro Pro Val Phe Asn 225 230 235 240 Pro Val Thr Tyr Ser Leu Arg Asn Asn Asp Met Lys Cys Ala Leu Ile 245 250 255 Arg Leu Leu Gln Lys Thr Tyr Gly Gln Glu Ala Tyr Phe Ile 260 265 270 <210> 507 < 211> 882 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(882) <400> 507 atg gga ttt tcg aat tcc tgg gat att cag att gta cat gct gct cta 48 Met Gly Phe Ser Asn Ser Trp Asp Ile Gln Ile Val His Ala Ala Leu 1 5 10 15 ttc ttc cta gtt tac ctg gca gct gtc ata gga aat ctc cta atc atc 96 Phe Phe Leu Val Tyr Leu Ala Ala Val Ile Gly Asn Leu Leu Ile Ile 20 25 30 ata ctt acc act ctg gat gtt cac ctc caa acc cca atg tat ttc ttt 144 Ile Leu Thr Thr Leu Asp Val His Leu Gln Thr Pro Met Tyr Phe Phe 35 40 45 ttg aga aac ttg tct ttc tta gat ttt tgt tac atc tct gtc aca att 192 Leu Arg Asn Leu Ser Phe Leu Asp Phe Cys Tyr Ile Ser Val Thr Ile 50 55 60 cca aaa tct att gtt agt tcc ttg act cat gat act tcc att tct ttc 240 Pro Lys Ser Ile Val Ser Ser Leu Thr His Asp Thr Ser Ile Ser Phe 65 70 75 80 ttt ggg tgt gct ctg caa gcc ttc ttt ttc atg gac ttg gca act acg 288 Phe Gly Cys Ala Leu Gln Ala Phe Phe Phe Met Asp Leu Ala Thr Thr 85 90 95 gag gta gcc atc ctt aca gtg atg tcc tat gac cgc tat atg gcc atc 336 Glu Val Ala Ile Leu Thr Val Met Ser Tyr Asp Arg Tyr Met Ala Ile 100 105 110 tgc cgg cct tta cat tat gag gtc atc ata aac caa ggt gtc tgt ctg 384 Cys Arg Pro Leu His Tyr Glu Val Ile Ile Asn Gln Gly Val Cys Leu 115 120 125 agg atg atg gcc atg tcg tgg ctc agt ggg gtg atc tgt gga ttc atg 432 Arg Met Met Ala Met Ser Trp Leu Ser Gly Val Ile Cys Gly Phe Met 130 135 140 cat gtg ata gca aca ttc tca tta cca ttc tgt ggg cgc aat aga ata 480 His Val Ile Ala Thr Phe Ser Leu Pro Phe Cys Gly Arg Asn Arg Ile 145 150 155 160 cgt caa ttt ttc tgt aat att cca cag ctc cta agc ctc tta gac ccc 528 Arg Gln Phe Phe Cys Asn Ile Pro Gln Leu Leu Ser Leu Leu Asp Pro 165 170 175 aaa gta att acc att gag att gga gtc atg gtt ttt ggt aca agt ctt 576 Lys Val Ile Thr Ile Glu Ile Gly Val Met Val Phe Gly Thr Ser Leu 180 185 190 gtg ata atc tcc ttt gtt gta att act ctc tcc tac atg tac att ttt 624 Val Ile Ile Ser Phe Val Val Ile Thr Leu Ser Tyr Met Tyr Ile Phe 195 200 205 tct gtc atc atg agg att cct tct aag gag ggt aga tca aaa aca ttt 672 Ser Val Ile Met Arg Ile Pro Ser Lys Glu Gly Arg Ser Lys Thr Phe 210 215 220 tct acc tgc att cca cat ctt gtg gtt gta aca ctc ttt atg ata tct 720 Ser Thr Cys Ile Pro His Leu Val Val Val Thr Leu Phe Met Ile Ser 225 230 235 240 ggc agc att gcc tat gtg aag cca att tca aat tct ccc ccc gtt ctg 768 Gly Ser Ile Ala Tyr Val Lys Pro Ile Ser Asn Ser Pro Pro Val Leu 245 250 255 gat gtt ttc ctg tct gcg ttc tac aca gtc gtg ccc ccg acc ctg aac 816 Asp Val Phe Leu Ser Ala Phe Tyr Thr Val Val Pro Pro Thr Leu Asn 260 265 270 ccc gtc atc tat agt ctg agg aat agg gac atg aag gca gcc ctg aga 864 Pro Val Ile Tyr Ser Leu Arg Asn Arg Asp Met Lys Ala Ala Leu Arg 275 280 285 agg cag tgt ggt ccc tga 882 Arg Gln Cys Gly Pro 290 <210> 508 <211> 293 <212> PRT <213> Homo sapiens <400> 508 Met Gly Phe Ser Asn Ser Trp Asp Ile Gln Ile Val His Ala Ala Leu 1 5 10 15 Phe Phe Leu Val Tyr Leu Ala Ala Val Ile Gly Asn Leu Leu Ile Ile 20 25 30 Ile Leu Thr Thr Leu Asp Val His Leu Gln Thr Pro Met Tyr Phe Phe 35 40 45 Leu Arg Asn Leu Ser Phe Leu Asp Phe Cys Tyr Ile Ser Val Thr Ile 50 55 60 Pro Lys Ser Ile Val Ser Ser Leu Thr His Asp Thr Ser Ile Ser Phe 65 70 75 80 Phe Gly Cys Ala Leu Gln Ala Phe Phe Phe Met Asp Leu Ala Thr Thr 85 90 95 Glu Val Ala Ile Leu Thr Val Met Ser Tyr Asp Arg Tyr Met Ala Ile 100 105 110 Cys Arg Pro Leu His Tyr Glu Val Ile Ile Asn Gln Gly Val Cys Leu 115 120 125 Arg Met Met Ala Met Ser Trp Leu Ser Gly Val Ile Cys Gly Phe Met 130 135 140 His Val Ile Ala Thr Phe Ser Leu Pro Phe Cys Gly Arg Asn Arg Ile 145 150 155 160 Arg Gln Phe Phe Cys Asn Ile Pro Gln Leu Leu Ser Leu Leu Asp Pro 165 170 175 Lys Val Ile Thr Ile Glu Ile Gly Val Met Val Phe Gly Thr Ser Leu 180 185 190 Val Ile Ile Ser Phe Val Val Ile Thr Leu Ser Tyr Met Tyr Ile Phe 195 200 205 Ser Val Ile Met Arg Ile Pro Ser Lys Glu Gly Arg Ser Lys Thr Phe 210 215 220 Ser Thr Cys Ile Pro His Leu Val Val Val Thr Leu Phe Met Ile Ser 225 230 235 240 Gly Ser Ile Ala Tyr Val Lys Pro Ile Ser Asn Ser Pro Pro Val Leu 245 250 255 Asp Val Phe Leu Ser Ala Phe Tyr Thr Val Val Pro Pro Thr Leu Asn 260 265 270 Pro Val Ile Tyr Ser Leu Arg Asn Arg Asp Met Lys Ala Ala Leu Arg 275 280 285 Arg Gln Cys Gly Pro 290 <210> 509 <211> 924 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(924) <400> 509 atg aat cac agc gtt gta act gag ttc att att ctg ggc ctc acc aaa 48 Met Asn His Ser Val Val Thr Glu Phe Ile Ile Leu Gly Leu Thr Lys 1 5 10 15 aag cct gaa ctc cag gga att atc ttc ctc ttt ttt ctc att gtc tat 96 Lys Pro Glu Leu Gln Gly Ile Ile Phe Leu Phe Phe Leu Ile Val Tyr 20 25 30 ctt gtg gct ttt ctc ggc aac atg ctc atc atc att gcc aaa atc tat 144 Leu Val Ala Phe Leu Gly Asn Met Leu Ile Ile Ile Ala Lys Ile Tyr 35 40 45 aac aac acc ttg cat acg ccc atg tat gtt ttc ctt ctg aca ctg gct 192 Asn Asn Thr Leu His Thr Pro Met Tyr Val Phe Leu Leu Thr Leu Ala 50 55 60 gtt gtg gac atc atc tgc aca aca agc atc ata ccg aag atg ctg ggg 240 Val Val Asp Ile Ile Cys Thr Thr Ser Ile Ile Pro Lys Met Leu Gly 65 70 75 80 acc atg cta aca tca gaa aat acc att tca tat gca ggc tgc atg tcc 288 Thr Met Leu Thr Ser Glu Asn Thr Ile Ser Tyr Ala Gly Cys Met Ser 85 90 95 cag ctc ttc ttg ttc aca tgg tct ctg gga gct gag atg gtt ctc ttc 336 Gln Leu Phe Leu Phe Thr Trp Ser Leu Gly Ala Glu Met Val Leu Phe 100 105 110 acc acc atg gcc tat gac cgc tat gtg gcc att tgt ttc cct ctt cat 384 Thr Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Phe Pro Leu His 115 120 125 tac agt act gtt atg aac cac cat atg tgt gta gcc ttg ctc agc atg 432 Tyr Ser Thr Val Met Asn His His Met Cys Val Ala Leu Leu Ser Met 130 135 140 gtc atg gct att gca gtc acc aat tcc tgg gtg cac aca gct ctt atc 480 Val Met Ala Ile Ala Val Thr Asn Ser Trp Val His Thr Ala Leu Ile 145 150 155 160 atg agg ttg act ttc tgt ggg cca aac acc att gac cac ttc ttc tgt 528 Met Arg Leu Thr Phe Cys Gly Pro Asn Thr Ile Asp His Phe Phe Cys 165 170 175 gag ata ccc cca ttg ctg gct ttg tcc tgt agc cct gta aga atc aat 576 Glu Ile Pro Pro Leu Leu Ala Leu Ser Cys Ser Pro Val Arg Ile Asn 180 185 190 gag gtg atg gtg tat gtt gct gat att acc ctg gcc ata ggg gac ttt 624 Glu Val Met Val Tyr Val Ala Asp Ile Thr Leu Ala Ile Gly Asp Phe 195 200 205 att ctt acc tgc atc tcc tat ggt ttt atc att gtt gct att ctc cgt 672 Ile Leu Thr Cys Ile Ser Tyr Gly Phe Ile Ile Val Ala Ile Leu Arg 210 215 220 atc cgc aca gta gaa ggc aag agg aag gcc ttc tca aca tgc tca tct 720 Ile Arg Thr Val Glu Gly Lys Arg Lys Ala Phe Ser Thr Cys Ser Ser 225 230 235 240 cat ctc aca gtg gtg acc ctt tac tat tct cct gta atc tac acc tat 768 His Leu Thr Val Val Thr Leu Tyr Tyr Ser Pro Val Ile Tyr Thr Tyr 245 250 255 atc cgc cct gct tcc agc tat aca ttt gaa aga gac aag gtg gta gct 816 Ile Arg Pro Ala Ser Ser Tyr Thr Phe Glu Arg Asp Lys Val Val Ala 260 265 270 gca ctc tat act ctt gtg act ccc aca tta aac ccg atg gtg tac agc 864 Ala Leu Tyr Thr Leu Val Thr Pro Thr Leu Asn Pro Met Val Tyr Ser 275 280 285 ttc cag aat agg gag atg cag gca gga att agg aag gtg ttt gca ttt 912 Phe Gln Asn Arg Glu Met Gln Ala Gly Ile Arg Lys Val Phe Ala Phe 290 295 300 ctg aaa cac tag 924 Leu Lys His 305 <210> 510 <211> 307 <212> PRT <213> Homo sapiens <400> 510 Met Asn His Ser Val Val Thr Glu Phe Ile Ile Leu Gly Leu Thr Lys 1 5 10 15 Lys Pro Glu Leu Gln Gly Ile Ile Phe Leu Phe Phe Leu Ile Val Tyr 20 25 30 Leu Val Ala Phe Leu Gly Asn Met Leu Ile Ile Ile Ala Lys Ile Tyr 35 40 45 Asn Asn Thr Leu His Thr Pro Met Tyr Val Phe Leu Leu Thr Leu Ala 50 55 60 Val Val Asp Ile Ile Cys Thr Thr Ser Ile Ile Pro Lys Met Leu Gly 65 70 75 80 Thr Met Leu Thr Ser Glu Asn Thr Ile Ser Tyr Ala Gly Cys Met Ser 85 90 95 Gln Leu Phe Leu Phe Thr Trp Ser Leu Gly Ala Glu Met Val Leu Phe 100 105 110 Thr Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Phe Pro Leu His 115 120 125 Tyr Ser Thr Val Met Asn His His Met Cys Val Ala Leu Leu Ser Met 130 135 140 Val Met Ala Ile Ala Val Thr Asn Ser Trp Val His Thr Ala Leu Ile 145 150 155 160 Met Arg Leu Thr Phe Cys Gly Pro Asn Thr Ile Asp His Phe Phe Cys 165 170 175 Glu Ile Pro Pro Leu Leu Ala Leu Ser Cys Ser Pro Val Arg Ile Asn 180 185 190 Glu Val Met Val Tyr Val Ala Asp Ile Thr Leu Ala Ile Gly Asp Phe 195 200 205 Ile Leu Thr Cys Ile Ser Tyr Gly Phe Ile Ile Val Ala Ile Leu Arg 210 215 220 Ile Arg Thr Val Glu Gly Lys Arg Lys Ala Phe Ser Thr Cys Ser Ser 225 230 235 240 His Leu Thr Val Val Thr Leu Tyr Tyr Ser Pro Val Ile Tyr Thr Tyr 245 250 255 Ile Arg Pro Ala Ser Ser Tyr Thr Phe Glu Arg Asp Lys Val Val Ala 260 265 270 Ala Leu Tyr Thr Leu Val Thr Pro Thr Leu Asn Pro Met Val Tyr Ser 275 280 285 Phe Gln Asn Arg Glu Met Gln Ala Gly Ile Arg Lys Val Phe Ala Phe 290 295 300 Leu Lys His 305 <210> 511 <211> 945 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(945) <400> 511 atg acc aat cag aca cag atg atg gaa ttc ttg ctt gtg aga ttt act 48 Met Thr Asn Gln Thr Gln Met Met Glu Phe Leu Leu Val Arg Phe Thr 1 5 10 15 gag aat tgg gtg ctc ctg agg ctg cat gct ttg ctc ttc tca ctg atc 96 Glu Asn Trp Val Leu Leu Arg Leu His Ala Leu Leu Phe Ser Leu Ile 20 25 30 tac ctc acg gct gtg ctg atg aat tta gtc atc att ctc ctc atg att 144 Tyr Leu Thr Ala Val Leu Met Asn Leu Val Ile Ile Leu Leu Met Ile 35 40 45 ctg gac cat cgt ctc cac atg gca atg tac ttt ttc ctc cga cat ttg 192 Leu Asp His Arg Leu His Met Ala Met Tyr Phe Phe Leu Arg His Leu 50 55 60 tcc ttc tta gac ctg tgt ctc att tct gcc aca gtc ccc aaa tcc atc 240 Ser Phe Leu Asp Leu Cys Leu Ile Ser Ala Thr Val Pro Lys Ser Ile 65 70 75 80 ctc aac tct gtc gcc tcc act gac tcc atc tcc ttc ctg ggg tgt gtg 288 Leu Asn Ser Val Ala Ser Thr Asp Ser Ile Ser Phe Leu Gly Cys Val 85 90 95 ttg cag ctc ttc ttg gtg gta ctg ctg gct gga tca gag att ggc atc 336 Leu Gln Leu Phe Leu Val Val Leu Leu Ala Gly Ser Glu Ile Gly Ile 100 105 110 ctt act gcc atg tcc tat gac cgc tat gct gcc atc tgc tgc ccc cta 384 Leu Thr Ala Met Ser Tyr Asp Arg Tyr Ala Ala Ile Cys Cys Pro Leu 115 120 125 cac tgt gag gct gtc atg agc aga ggg ctc tgt gtc cag ttg atg gct 432 His Cys Glu Ala Val Met Ser Arg Gly Leu Cys Val Gln Leu Met Ala 130 135 140 ctg tcc tgg ctc aac aga ggg gcc ttg gga ctc ttg tac aca gct gga 480 Leu Ser Trp Leu Asn Arg Gly Ala Leu Gly Leu Leu Tyr Thr Ala Gly 145 150 155 160 aca ttc tct ctg aat ttt tat ggc tct gat gag cta cat cag ttc ttc 528 Thr Phe Ser Leu Asn Phe Tyr Gly Ser Asp Glu Leu His Gln Phe Phe 165 170 175 tgc gat gtc cct gcc cta cta aag ctc act tgt tct aaa gaa cat gcc 576 Cys Asp Val Pro Ala Leu Leu Lys Leu Thr Cys Ser Lys Glu His Ala 180 185 190 atc att agt gtc agt gtg gcc att ggg gtc tgt tat gca ttt tca tgt 624 Ile Ile Ser Val Ser Val Ala Ile Gly Val Cys Tyr Ala Phe Ser Cys 195 200 205 tta gtt tgc att gta gtt tcc tat gtg tac att ttc tct gct gtg tta 672 Leu Val Cys Ile Val Val Ser Tyr Val Tyr Ile Phe Ser Ala Val Leu 210 215 220 agg ata tca cag aga cag aga caa tcc aaa gcc ttt tcc aac tgt gtg 720 Arg Ile Ser Gln Arg Gln Arg Gln Ser Lys Ala Phe Ser Asn Cys Val 225 230 235 240 cct cac ctc att gtt gtc act gtg ttt ctt gta aca ggt gct gtt gct 768 Pro His Leu Ile Val Val Thr Val Phe Leu Val Thr Gly Ala Val Ala 245 250 255 tat tta aag cca ggg tct gat gca cct tct att cta gac ttg ctg gtg 816 Tyr Leu Lys Pro Gly Ser Asp Ala Pro Ser Ile Leu Asp Leu Leu Val 260 265 270 tct gtg ttc tat tct gtc gca cct cca acc ttg aac cct gtt atc tac 864 Ser Val Phe Tyr Ser Val Ala Pro Pro Thr Leu Asn Pro Val Ile Tyr 275 280 285 tgt ctg aag aac aag gac att aaa tcc gct ctg agt aaa gtc ctg tgg 912 Cys Leu Lys Asn Lys Asp Ile Lys Ser Ala Leu Ser Lys Val Leu Trp 290 295 300 aat gtt aga agc agt ggg gta atg aaa aga tga 945 Asn Val Arg Ser Ser Gly Val Met Lys Arg 305 310 315 <210> 512 <211> 314 <212> PRT <213> Homo sapiens <400> 512 Met Thr Asn Gln Thr Gln Met Met Glu Phe Leu Leu Val Arg Phe Thr 1 5 10 15 Glu Asn Trp Val Leu Leu Arg Leu His Ala Leu Leu Phe Ser Leu Ile 20 25 30 Tyr Leu Thr Ala Val Leu Met Asn Leu Val Ile Ile Leu Leu Met Ile 35 40 45 Leu Asp His Arg Leu His Met Ala Met Tyr Phe Phe Leu Arg His Leu 50 55 60 Ser Phe Leu Asp Leu Cys Leu Ile Ser Ala Thr Val Pro Lys Ser Ile 65 70 75 80 Leu Asn Ser Val Ala Ser Thr Asp Ser Ile Ser Phe Leu Gly Cys Val 85 90 95 Leu Gln Leu Phe Leu Val Val Leu Leu Ala Gly Ser Glu Ile Gly Ile 100 105 110 Leu Thr Ala Met Ser Tyr Asp Arg Tyr Ala Ala Ile Cys Cys Pro Leu 115 120 125 His Cys Glu Ala Val Met Ser Arg Gly Leu Cys Val Gln Leu Met Ala 130 135 140 Leu Ser Trp Leu Asn Arg Gly Ala Leu Gly Leu Leu Tyr Thr Ala Gly 145 150 155 160 Thr Phe Ser Leu Asn Phe Tyr Gly Ser Asp Glu Leu His Gln Phe Phe 165 170 175 Cys Asp Val Pro Ala Leu Leu Lys Leu Thr Cys Ser Lys Glu His Ala 180 185 190 Ile Ile Ser Val Ser Val Ala Ile Gly Val Cys Tyr Ala Phe Ser Cys 195 200 205 Leu Val Cys Ile Val Val Ser Tyr Val Tyr Ile Phe Ser Ala Val Leu 210 215 220 Arg Ile Ser Gln Arg Gln Arg Gln Ser Lys Ala Phe Ser Asn Cys Val 225 230 235 240 Pro His Leu Ile Val Val Thr Val Phe Leu Val Thr Gly Ala Val Ala 245 250 255 Tyr Leu Lys Pro Gly Ser Asp Ala Pro Ser Ile Leu Asp Leu Leu Val 260 265 270 Ser Val Phe Tyr Ser Val Ala Pro Pro Thr Leu Asn Pro Val Ile Tyr 275 280 285 Cys Leu Lys Asn Lys Asp Ile Lys Ser Ala Leu Ser Lys Val Leu Trp 290 295 300 Asn Val Arg Ser Ser Gly Val Met Lys Arg 305 310 <210> 513 <211> 951 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(951) <400> 513 atg gag ctc tgg aac ttc acc ttg gga agt ggc ttc att ttg gtg ggg 48 Met Glu Leu Trp Asn Phe Thr Leu Gly Ser Gly Phe Ile Leu Val Gly 1 5 10 15 att ctg aat gac agt ggg tct cct gaa ctg ctc tgt gct aca att aca 96 Ile Leu Asn Asp Ser Gly Ser Pro Glu Leu Leu Cys Ala Thr Ile Thr 20 25 30 a tc cta tac ttg ttg gcc ctg atc agc aat ggc cta ctg ctc ctg gct 144 Ile Leu Tyr Leu Leu Ala Leu Ile Ser Asn Gly Leu Leu Leu Leu Ala 35 40 45 atc acc atg gaa gcc cgg ctc cac atg ccc atg tac ctc ctg ctt ggg 192 Ile Thr Met Glu Ala Arg Leu His Met Pro Met Tyr Leu Leu Leu Gly 50 55 60 cag ctc tct ctc atg gac ctc ctg ttc aca tct gtt gtc act ccc aag 240 Gln Leu Ser Leu Met Asp Leu Leu Phe Thr Ser Val Val Thr Pro Lys 65 70 75 80 gcc ctt gcg gac ttt ctg cgc aga gaa aac acc atc tcc ttt gga ggc 288 Ala Leu Ala Asp Phe Leu Arg Arg Glu Asn Thr Ile Ser Phe Gly Gly 85 90 95 tgt gcc ctt cag atg ttc ctg gca ctg aca atg ggt ggt gct gag gac 336 Cys Ala Leu Gln Met Phe Leu Ala Leu Thr Met Gly Gly Ala Glu Asp 100 105 110 ctc cta ctg gcc ttc atg gcc tat gac agg tat gtg gcc att tgt cat 384 Leu Leu Leu Ala Phe Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 cct ctg aca tac atg acc ctc atg agc tca aga gcc tgc tgg ctc atg 432 Pro Leu Thr Tyr Met Thr Leu Met Ser Ser Arg Ala Cys Trp Leu Met 130 135 140 gtg gcc acg tcc tgg atc ctg gca tcc cta agt gcc cta ata tat acc 480 Val Ala Thr Ser Trp Ile Leu Ala Ser Leu Ser Ala Leu Ile Tyr Thr 145 150 155 160 gtg tat acc atg cac tat ccc ttc tgc agg gcc cag gag atc agg cat 528 Val Tyr Thr Met His Tyr Pro Phe Cys Arg Ala Gln Glu Ile Arg His 165 170 175 ctt ctc tgt gag atc cca cac ttg ctg aag gtg gcc tgt gct gat acc 576 Leu Leu Cys Glu Ile Pro His Leu Leu Lys Val Ala Cys Ala Asp Thr 180 185 190 tcc aga tat gag ctc atg gta tat gtg atg ggt gtg acc ttc ctg att 624 Ser Arg Tyr Glu Leu Met Val Tyr Val Met Gly Val Thr Phe Leu Ile 195 200 205 ccc tct ctt gct gct ata ctg gcc tcc tat aca caa att cta ctc act 672 Pro Ser Leu Ala Ala Ile Leu Ala Ser Tyr Thr Gln Ile Leu Leu Thr 210 215 220 gtg ctc cat atg cca tca aat gag ggg agg aag aaa gcc ctt gtc acc 720 Val Leu His Met Pro Ser Asn Glu Gly Arg Lys Lys Ala Leu Val Thr 225 230 235 240 tgc tct tcc cac ctg act gtg gtt ggg atg ttc tat gga gct gcc aca 768 Cys Ser Ser His Leu Thr Val Val Gly Met Phe Tyr Gly Ala Ala Thr 245 250 255 ttc atg tat gtc ttg ccc agt tcc ttc cac agc acc aga caa gac aac 816 Phe Met Tyr Val Leu Pro Ser Ser Phe His Ser Thr Arg Gln Asp Asn 260 265 270 atc atc tct gtt ttc tac aca att gtc act cca gcc ctg aat cca ctc 864 Ile Ile Ser Val Phe Tyr Thr Ile Val Thr Pro Ala Leu Asn Pro Leu 275 280 285 atc tac agc ctg agg aat aag gag gtc atg cgg gcc ttg agg agg gtc 912 Ile Tyr Ser Leu Arg Asn Lys Glu Val Met Arg Ala Leu Arg Arg Val 290 295 300 ctg gga aaa tac atg ctg cca gca cac tcc acg ctc tag 951 Leu Gly Lys Tyr Met Leu Pro Ala His Ser Thr Leu 305 310 315 <210> 514 <211> 316 <212> PRT <213> Homo sapiens <400> 514 Met Glu Leu Trp Asn Phe Thr Leu Gly Ser Gly Phe Ile Leu Val Gly 1 5 10 15 Ile Leu Asn Asp Ser Gly Ser Pro Glu Leu Leu Cys Ala Thr Ile Thr 20 25 30 Ile Leu Tyr Leu Leu Ala Leu Ile Ser Asn Gly Leu Leu Leu Leu Ala 35 40 45 Ile Thr Met Glu Ala Arg Leu His Met Pro Met Tyr Leu Leu Leu Gly 50 55 60 Gln Leu Ser Leu Met Asp Leu Leu Phe Thr Ser Val Val Thr Pro Lys 65 70 75 80 Ala Leu Ala Asp Phe Leu Arg Arg Glu Asn Thr Ile Ser Phe Gly Gly 85 90 95 Cys Ala Leu Gln Met Phe Leu Ala Leu Thr Met Gly Gly Ala Glu Asp 100 105 110 Leu Leu Leu Ala Phe Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu Thr Tyr Met Thr Leu Met Ser Ser Arg Ala Cys Trp Leu Met 130 135 140 Val Ala Thr Ser Trp Ile Leu Ala Ser Leu Ser Ala Leu Ile Tyr Thr 145 150 155 160 Val Tyr Thr Met His Tyr Pro Phe Cys Arg Ala Gln Glu Ile Arg His 165 170 175 Leu Leu Cys Glu Ile Pro His Leu Leu Lys Val Ala Cys Ala Asp Thr 180 185 190 Ser Arg Tyr Glu Leu Met Val Tyr Val Met Gly Val Thr Phe Leu Ile 195 200 205 Pro Ser Leu Ala Ala Ile Leu Ala Ser Tyr Thr Gln Ile Leu Leu Thr 210 215 220 Val Leu His Met Pro Ser Asn Glu Gly Arg Lys Lys Ala Leu Val Thr 225 230 235 240 Cys Ser Ser His Leu Thr Val Val Gly Met Phe Tyr Gly Ala Ala Thr 245 250 255 Phe Met Tyr Val Leu Pro Ser Ser Phe His Ser Thr Arg Gln Asp Asn 260 265 270 Ile Ile Ser Val Phe Tyr Thr Ile Val Thr Pro Ala Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Val Met Arg Ala Leu Arg Arg Val 290 295 300 Leu Gly Lys Tyr Met Leu Pro Ala His Ser Thr Leu 305 310 315 <210> 515 <211> 936 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(936) <400> 515 atg gaa aac caa tcc agc att tct gaa ttt ttc ctc cga gga ata tca 48 Met Glu Asn Gln Ser Ser Ile Ser Glu Phe Phe Leu Arg Gly Ile Ser 1 5 10 15 gcg cct cca gag caa cag cag tcc ctc ttc gga att ttc ctg tgt atg 96 Ala Pro Pro Glu Gln Gln Gln Ser Leu Phe Gly Ile Phe Leu Cys Met 20 25 30 tat ctt gtc acc ttg act ggg aac ctg ctc atc atc ctg gcc att ggc 144 Tyr Leu Val Thr Leu Thr Gly Asn Leu Leu Ile Ile Leu Ala Ile Gly 35 40 45 tct gac ctg cac ctc cac acc ccc atg tac ttt ttc ttg gcc aac ctg 192 Ser Asp Leu His Leu His Thr Pro Met Tyr Phe Phe Leu Ala Asn Leu 50 55 60 tct ttt gtt gac atg ggt tta acg tcc tcc aca gtt acc aag atg ctg 240 Ser Phe Val Asp Met Gly Leu Thr Ser Ser Thr Val Thr Lys Met Leu 65 70 75 80 gtg aat ata cag act cgg cat cac acc atc tcc tat acg ggt tgc ctc 288 Val Asn Ile Gln Thr Arg His His Thr Ile Ser Tyr Thr Gly Cys Leu 85 90 95 acg caa atg tat ttc ttt ctg atg ttt ggt gat cta gac agc ttc ttc 336 Thr Gln Met Tyr Phe Phe Leu Met Phe Gly Asp Leu Asp Ser Phe Phe 100 105 110 ctg gct gcc atg gcg tat gac cgc tat gtg gcc att tgc cac ccc ctc 384 Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His Pro Leu 115 120 125 tgc tac tcc aca gtc atg agg ccc caa gtc tgt gcc cta atg ctt gca 432 Cys Tyr Ser Thr Val Met Arg Pro Gln Val Cys Ala Leu Met Leu Ala 130 135 140 ttg tgc tgg gtc ctc acc aat atc gtt gcc ctg act cac acg ttc ctc 480 Leu Cys Trp Val Leu Thr Asn Ile Val Ala Leu Thr His Thr Phe Leu 145 150 155 160 atg gct cgg ttg tcc ttc tgt gtg act ggg gaa att gct cac ttt ttc 528 Met Ala Arg Leu Ser Phe Cys Val Thr Gly Glu Ile Ala His Phe Phe 165 170 175 tgt gac atc act cct gtc ctg aag ctg tca tgt tct gac acc cac atc 576 Cys Asp Ile Thr Pro Val Leu Lys Leu Ser Cys Ser Asp Thr His Ile 180 185 190 aac gag atg atg gtt ttt gtc ttg gga ggc acc gta ctc atc gtc ccc 624 Asn Glu Met Met Val Phe Val Leu Gly Gly Thr Val Leu Ile Val Pro 195 200 205 ttt tta tgc att gtc acc tcc tac atc cac att gtg cca gct atc ctg 672 Phe Leu Cys Ile Val Thr Ser Tyr Ile His Ile Val Pro Ala Ile Leu 210 215 220 agg gtc cga acc cgt ggt ggg gtg ggc aag gcc ttt tcc acc tgc agt 720 Arg Val Arg Thr Arg Gly Gly Val Gly Lys Ala Phe Ser Thr Cys Ser 225 230 235 240 tcc cac ctc tgc gtt gtt tgt gtg ttc tat ggg acc ctc ttc agt gcc 768 Ser His Leu Cys Val Val Cys Val Phe Tyr Gly Thr Leu Phe Ser Ala 245 250 255 tac ctg tgt cct ccc tcc att gcc tct gaa gag aag gac att gca gca 816 Tyr Leu Cys Pro Pro Ser Ile Ala Ser Glu Glu Lys Asp Ile Ala Ala 260 265 270 gct gca atg tac acc ata gtg act ccc atg ttg aac ccc ttt atc tat 864 Ala Ala Met Tyr Thr Ile Val Thr Pro Met Leu Asn Pro Phe Ile Tyr 275 280 285 agc cta agg aac aag gac atg aag ggg gcc cta aag agg ctc ttc agt 912 Ser Leu Arg Asn Lys Asp Met Lys Gly Ala Leu Lys Arg Leu Phe Ser 290 295 300 cac agg agt att gtt tcc tct tag 936 His Arg Ser Ile Val Ser Ser 305 310 <210> 516 <211> 311 <212> PRT <213> Homo sapiens <400> 516 Met Glu Asn Gln Ser Ser Ile Ser Glu Phe Phe Leu Arg Gly Ile Ser 1 5 10 15 Ala Pro Pro Glu Gln Gln Gln Ser Leu Phe Gly Ile Phe Leu Cys Met 20 25 30 Tyr Leu Val Thr Leu Thr Gly Asn Leu Leu Ile Ile Leu Ala Ile Gly 35 40 45 Ser Asp Leu His Leu His Thr Pro Met Tyr Phe Phe Leu Ala Asn Leu 50 55 60 Ser Phe Val Asp Met Gly Leu Thr Ser Ser Thr Val Thr Lys Met Leu 65 70 75 80 Val Asn Ile Gln Thr Arg His His Thr Ile Ser Tyr Thr Gly Cys Leu 85 90 95 Thr Gln Met Tyr Phe Phe Leu Met Phe Gly Asp Leu Asp Ser Phe Phe 100 105 110 Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His Pro Leu 115 120 125 C ys Tyr Ser Thr Val Met Arg Pro Gln Val Cys Ala Leu Met Leu Ala 130 135 140 Leu Cys Trp Val Leu Thr Asn Ile Val Ala Leu Thr His Thr Phe Leu 145 150 155 160 Met Ala Arg Leu Ser Phe Cys Val Thr Gly Glu Ile Ala His Phe Phe 165 170 175 Cys Asp Ile Thr Pro Val Leu Lys Leu Ser Cys Ser Asp Thr His Ile 180 185 190 Asn Glu Met Met Val Phe Val Leu Gly Gly Thr Val Leu Ile Val Pro 195 200 205 Phe Leu Cys Ile Val Thr Ser Tyr Ile His Ile Val Pro Ala Ile Leu 210 215 220 Arg Val Arg Thr Arg Gly Gly Val Gly Lys Ala Phe Ser Thr Cys Ser 225 230 235 240 Ser His Leu Cys Val Val Cys Val Phe Tyr Gly Thr Leu Phe Ser Ala 245 250 255 Tyr Leu Cys Pro Pro Ser Ile Ala Ser Glu Glu Lys Asp Ile Ala Ala 260 265 270 Ala Ala Met Tyr Thr Ile Val Thr Pro Met Leu Asn Pro Phe Ile Tyr 275 280 285 Ser Leu Arg Asn Lys Asp Met Lys Gly Ala Leu Lys Arg Leu Phe Ser 290 295 300 His Arg Ser Ile Val Ser Ser 305 310 <210> 517 <211> 936 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(936) <400> 517 atg gga agt ttc aac acc agt ttt gaa gat ggc ttc att ttg gtg gga 48 Met Gly Ser Phe Asn Thr Ser Phe Glu Asp Gly Phe Ile Leu Val Gly 1 5 10 15 ttc tca gat tgg ccg caa ctg gag ccc atc ctg ttt gtc ttt att ttt 96 Phe Ser Asp Trp Pro Gln Leu Glu Pro Ile Leu Phe Val Phe Ile Phe 20 25 30 att ttc tac tcc cta act ctc ttt ggc aac acc atc atc atc gct ctc 144 Ile Phe Tyr Ser Leu Thr Leu Phe Gly Asn Thr Ile Ile Ile Ala Leu 35 40 45 tcc tgg cta gac ctt cgg ctg cac aca cct atg tac ttc ttt ctc tct 192 Ser Trp Leu Asp Leu Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 cat ctg tcc ctc ctg gac ctc tgc ttc acc acc agc acc gtg ccc cag 240 His Leu Ser Leu Leu Asp Leu Cys Phe Thr Thr Ser Thr Val Pro Gln 65 70 75 80 ctc ctg atc aac ctt tgc ggg gtg gac cgc acc atc acc cgt gga ggg 288 Leu Leu Ile Asn Leu Cys Gly Val Asp Arg Thr Ile Thr Arg Gly Gly 85 90 95 tgt gtg gct cag ctc ttc atc tac cta gcc ctg ggc tcc aca gag tgt 336 Cys Val Ala Gln Leu Phe Ile Tyr Leu Ala Leu Gly Ser Thr Glu Cys 100 105 110 gtg ctc ctg gtg gtg atg gcc ttt gac cgc tat gct gct gtc tgt cgt 384 Val Leu Leu Val Val Met Ala Phe Asp Arg Tyr Ala Ala Val Cys Arg 115 120 125 cca ctc cac tac atg gcc atc atg cac ccc cat ctc tgc cag acc ctg 432 Pro Leu His Tyr Met Ala Ile Met His Pro His Leu Cys Gln Thr Leu 130 135 140 gct atc gcc tcc tgg ggt gcg ggt ttc gtg aac tct ctg atc cag aca 480 Ala Ile Ala Ser Trp Gly Ala Gly Phe Val Asn Ser Leu Ile Gln Thr 145 150 155 160 ggt ctc gca atg gcc atg cct ctc tgt ggc cat cga ctg aat cac ttc 528 Gly Leu Ala Met Ala Met Pro Leu Cys Gly His Arg Leu Asn His Phe 165 170 175 ttc tgt gag atg cct gta ttt ctg aag ttg gct tgt gcg gac aca gaa 576 Phe Cys Glu Met Pro Val Phe Leu Lys Leu Ala Cys Ala Asp Thr Glu 180 185 190 gga aca gag gcc aag atg ttt gtg gcc cga gtc ata gtc gtg gct gtt 624 Gly Thr Glu Ala Lys Met Phe Val Ala Arg Val Ile Val Val Ala Val 195 200 205 cct gca gca ctt att cta ggc tcc tat gtg cac att gct cat gca gtg 672 Pro Ala Ala Leu Ile Leu Gly Ser Tyr Val His Ile Ala His Ala Val 210 215 220 ctg agg gtg aag tca acg gct ggg cgc aga aag gct ttt ggg act tgt 720 Leu Arg Val Lys Ser Thr Ala Gly Arg Arg Lys Ala Phe Gly Thr Cys 225 230 235 240 ggg tcc cac ctc cta gta gtt ttc ctt ttt tat ggc tca gcc atc tac 768 Gly Ser His Leu Leu Val Val Phe Leu Phe Tyr Gly Ser Ala Ile Tyr 245 250 255 aca tat ctc caa tcc atc cac aat tat tct gag cgt gag gga aaa ttt 816 Thr Tyr Leu Gln Ser Ile His Asn Tyr Ser Glu Arg Glu Gly Lys Phe 260 265 270 gtt gcc ctt ttt tat act ata att acc ccc att ctc aat cct ctc att 864 Val Ala Leu Phe Tyr Thr Ile Ile Thr Pro Ile Leu Asn Pro Leu Ile 275 280 285 tat aca cta aga aac aag gac gtg aag ggg gct ctg tgg aaa gta cta 912 Tyr Thr Leu Arg Asn Lys Asp Val Lys Gly Ala Leu Trp Lys Val Leu 290 295 300 tgg agg ggc agg gac tca ggg tag 936 Trp Arg Gly Arg Asp Ser Gly 305 310 <210> 518 <211> 311 <212> PRT <213> Homo sapiens <400> 518 Met Gly Ser Phe Asn Thr Ser Phe Glu Asp Gly Phe Ile Leu Val Gly 1 5 10 15 Phe Ser Asp Trp Pro Gln Leu Glu Pro Ile Leu Phe Val Phe Ile Phe 20 25 30 Ile Phe Tyr Ser Leu Thr Leu Phe Gly Asn Thr Ile Ile Ile Ala Leu 35 40 45 Ser Trp Leu Asp Leu Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 His Leu Ser Leu Leu Asp Leu Cys Phe Thr Thr Ser Thr Val Pro Gln 65 70 75 80 Leu Leu Ile Asn Leu Cys Gly Val Asp Arg Thr Ile Thr Arg Gly Gly 85 90 95 Cys Val Ala Gln Leu Phe Ile Tyr Leu Ala Leu Gly Ser Thr Glu Cys 100 105 110 Val Leu Leu Val Val Met Ala Phe Asp Arg Tyr Ala Ala Val Cys Arg 115 120 125 Pro Leu His Tyr Met Ala Ile Met His Pro His Leu Cys Gln Thr Leu 130 135 140 Ala Ile Ala Ser Trp Gly Ala Gly Phe Val Asn Ser Leu Ile Gln Thr 145 150 155 160 Gly Leu Ala Met Ala Met Pro Leu Cys Gly His Arg Leu Asn His Phe 165 170 175 Phe Cys Glu Met Pro Val Phe Leu Lys Leu Ala Cys Ala Asp Thr Glu 180 185 190 Gly Thr Glu Ala Lys Met Phe Val Ala Arg Val Ile Val Val Ala Val 195 200 205 Pro Ala Ala Leu Ile Leu Gly Ser Tyr Val His Ile Ala His Ala Val 210 215 220 Leu Arg Val Lys Ser Thr Ala Gly Arg Arg Lys Ala Phe Gly Thr Cys 225 230 235 240 Gly Ser His Leu Leu Val Val Phe Leu Phe Tyr Gly Ser Ala Ile Tyr 245 250 255 Thr Tyr Leu Gln Ser Ile His Asn Tyr Ser Glu Arg Glu Gly Lys Phe 260 265 270 Val Ala Leu Phe Tyr Thr Ile Ile Thr Pro Ile Leu Asn Pro Leu Ile 275 280 285 Tyr Thr Leu Arg Asn Lys Asp Val Lys Gly Ala Leu Trp Lys Val Leu 290 295 300 Trp Arg Gly Arg Asp Ser Gly 305 310 <210> 519 <211> 894 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(894) <400> 519 atg cta gtg tca caa cag gag cag cct ctt ctg ttt ggc atc ttc ctt 48 Met Leu Val Ser Gln Gln Glu Gln Pro Leu Leu Phe Gly Ile Phe Leu 1 5 10 15 ggc atg tac ctg gtc acc atg gtg ggg aac ctg ctc att atc ctg gcc 96 Gly Met Tyr Leu Val Thr Met Val Gly Asn Leu Leu Ile Ile Leu Ala 20 25 30 atc agc tct gac cca cac ctc cat act ccc atg tac ttc ttt ctg gcc 144 Ile Ser Ser Asp Pro His Leu His Thr Pro Met Tyr Phe Phe Leu Ala 35 40 45 aac ctg tca tta act gat gcc tgt ttc act tct gcc tcc atc ccc aaa 192 Asn Leu Ser Leu Thr Asp Ala Cys Phe Thr Ser Ala Ser Ile Pro Lys 50 55 60 atg ctg gcc aac att cat acc cag agt cag atc atc tcg tat tct ggg 240 Met Leu Ala Asn Ile His Thr Gln Ser Gln Ile Ile Ser Tyr Ser Gly 65 70 75 80 tgt ctt gca cag cta tat ttc ctc ctt atg ttt ggt ggc ctt gac aac 288 Cys Leu Ala Gln Leu Tyr Phe Leu Leu Met Phe Gly Gly Leu Asp Asn 85 90 95 tgc ctg ctg gct gtg atg gca tat gac cgc tat gtg gcc atc tgc caa 336 Cys Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Gln 100 105 110 cca ctc cat tac agc aca tct atg agt ccc cag ctc tgt gca cta atg 384 Pro Leu His Tyr Ser Thr Ser Met Ser Pro Gln Leu Cys Ala Leu Met 115 120 125 ctg ggt gtg tgc tgg gtg cta acc aac tgt cct gcc ctg atg cac aca 432 Leu Gly Val Cys Trp Val Leu Thr Asn Cys Pro Ala Leu Met His Thr 130 135 140 ctg ttg ctg acc cgc gtg gct ttc tgt gcc cag aaa gcc atc cct cat 480 Leu Leu Leu Thr Arg Val Ala Phe Cys Ala Gln Lys Ala Ile Pro His 145 150 155 160 ttc tat tgt gat cct agt gct ctc ctg aag ctt gcc tgc tca gat acc 528 Phe Tyr Cys Asp Pro Ser Ala Leu Leu Lys Leu Ala Cys Ser Asp Thr 165 170 175 cat gta aac gag ctg atg atc atc acc atg ggc ttg ctg ttc ctc act 576 His Val Asn Glu Leu Met Ile Ile Thr Met Gly Leu Leu Phe Leu Thr 180 185 190 gtt ccc ctc ctg ctg atc gtc ttc tcc tat gtc cgc att ttc tgg gct 624 Val Pro Leu Leu Leu Ile Val Phe Ser Tyr Val Arg Ile Phe Trp Ala 195 200 205 gtg ttt gtc atc tca tct cct gga ggg aga tgg aag gcc ttc tct acc 672 Val Phe Val Ile Ser Ser Pro Gly Gly Arg Trp Lys Ala Phe Ser Thr 210 215 220 tgt ggt tct cat ctc acg gtg gtt ctg ctc ttc tat ggg tct ctt atg 720 Cys Gly Ser His Leu Thr Val Val Leu Leu Phe Tyr Gly Ser Leu Met 225 230 235 240 ggt gtg tat tta ctt cct cca tca act tac tct aca gag agg gaa agt 768 Gly Val Tyr Leu Leu Pro Pro Ser Thr Tyr Ser Thr Glu Arg Glu Ser 245 250 255 agg gct gct gtt ctc tat atg gtg att att ccc acg cta aac cca ttc 816 Arg Ala Ala Val Leu Tyr Met Val Ile Ile Pro Thr Leu Asn Pro Phe 260 265 270 att tat agc ttg agg aac aga gac atg aag gag gct ttg ggt aaa ctt 864 Ile Tyr Ser Leu Arg Asn Arg Asp Met Lys Glu Ala Leu Gly Lys Leu 275 280 285 ttt gtc agt gga aaa aca ttc ttt tta tga 894 Phe Val Ser Gly Lys Thr Phe Phe Leu 290 295 <210> 520 <211> 297 <212> PRT <213> Homo sapiens <400> 520 Met Leu Val Ser Gln Gln Glu Gln Pro Leu Leu Phe Gly Ile Phe Leu 1 5 10 15 Gly Met Tyr Leu Val Thr Met Val Gly Asn Leu Leu Ile Ile Leu Ala 20 25 30 Ile Ser Ser Asp Pro His Leu His Thr Pro Met Tyr Phe Phe Leu Ala 35 40 45 Asn Leu Ser Leu Thr Asp Ala Cys Phe Thr Ser Ala Ser Ile Pro Lys 50 55 60 Met Leu Ala Asn Ile His Thr Gln Ser Gln Ile Ile Ser Tyr Ser Gly 65 70 75 80 Cys Leu Ala Gln Leu Tyr Phe Leu Leu Met Phe Gly Gly Leu Asp Asn 85 90 95 Cys Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Gln 100 105 110 Pro Leu His Tyr Ser Thr Ser Met Ser Pro Gln Leu Cys Ala Leu Met 115 120 125 Leu Gly Val Cys Trp Val Leu Thr Asn Cys Pro Ala Leu Met His Thr 130 135 140 Leu Leu Leu Thr Arg Val Ala Phe Cys Ala Gln Lys Ala Ile Pro His 145 150 155 160 Phe Tyr Cys Asp Pro Ser Ala Leu Leu Lys Leu Ala Cys Ser Asp Thr 165 170 175 His Val Asn Glu Leu Met Ile Ile Thr Met Gly Leu Leu Phe Leu Thr 180 185 190 Val Pro Leu Leu Leu Ile Val Phe Ser Tyr Val Arg Ile Phe Trp Ala 195 200 205 Val Phe Val Ile Ser Ser Pro Gly Gly Arg Trp Lys Ala Phe Ser Thr 210 215 220 Cys Gly Ser His Leu Thr Val Val Leu Leu Phe Tyr Gly Ser Leu Met 225 230 235 240 Gly Val Tyr Leu Leu Pro Pro Ser Thr Tyr Ser Thr Glu Arg Glu Ser 245 250 255 Arg Ala Ala Val Leu Tyr Met Val Ile Ile Pro Thr Leu Asn Pro Phe 260 265 270 Ile Tyr Ser Leu Arg Asn Arg Asp Met Lys Glu Ala Leu Gly Lys Leu 275 280 285 Phe Val Ser Gly Lys Thr Phe Phe Leu 290 295 <210> 521 <211> 945 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(945) <400> 521 atg gac aac agc aac tgg acc agt gtg tcc cat ttt gtt ctc ttg ggc 48 Met Asp Asn Ser Asn Trp Thr Ser Val Ser His Phe Val Leu Leu Gly 1 5 10 15 att tcc acc cac cca gaa gag caa atc cca ctc ttc ctt gtt ttc tca 96 Ile Ser Thr His Pro Glu Glu Gln Ile Pro Leu Phe Leu Val Phe Ser 20 25 30 ctc atg tac gca atc aat att tct ggc aac ttg gcc atc atc aca ctg 144 Leu Met Tyr Ala Ile Asn Ile Ser Gly Asn Leu Ala Ile Ile Thr Leu 35 40 45 att ctc tct gct cca cgc ctc cac atc ccc atg tac atc ttc ctc agt 192 Ile Leu Ser Ala Pro Arg Leu His Ile Pro Met Tyr Ile Phe Leu Ser 50 55 60 aac ttg gcc ttg aca gac atc tgc ttc acc tcc acc acg gtc ccc aag 240 Asn Leu Ala Leu Thr Asp Ile Cys Phe Thr Ser Thr Thr Val Pro Lys 65 70 75 80 atg ctg cag att att ttc tcc cct aca aag gta att tcc tac aca ggc 288 Met Leu Gln Ile Ile Phe Ser Pro Thr Lys Val Ile Ser Tyr Thr Gly 85 90 95 tgt tta gcc caa act tat ttc ttc att tgc ttc gcc gtc atg gaa aac 336 Cys Leu Ala Gln Thr Tyr Phe Phe Ile Cys Phe Ala Val Met Glu Asn 100 105 110 ttc atc ctg gct gtg atg gcc tat gac agg tac att gcc atc tgc cac 384 Phe Ile Leu Ala Val Met Ala Tyr Asp Arg Tyr Ile Ala Ile Cys His 115 120 125 cct ttc cac tac act atg atc ctg act aga atg ctg tgt gtg aag atg 432 Pro Phe His Tyr Thr Met Ile Leu Thr Arg Met Leu Cys Val Lys Met 130 135 140 gtg gtc atg tgc cat gct ctc tcc cac ctt cat gcc atg ctg cat acc 480 Val Val Met Cys His Ala Leu Ser His Leu His Ala Met Leu His Thr 145 150 155 160 ttt ctc ata ggc caa cta atc ttc tgt gca gat aac aga atc ccc cac 528 Phe Leu Ile Gly Gln Leu Ile Phe Cys Ala Asp Asn Arg Ile Pro His 165 170 175 t tc ttc tgt gac ctc tac gct ctg atg aag atc tcc tgc acc agc acc 576 Phe Phe Cys Asp Leu Tyr Ala Leu Met Lys Ile Ser Cys Thr Ser Thr 180 185 190 tac ctc aac acc ctt atg att cac aca gaa ggt gct gtt gta atc agt 624 Tyr Leu Asn Thr Leu Met Ile His Thr Glu Gly Ala Val Val Ile Ser 195 200 205 gga gct ctg gcc ttc att act gcc tcc tat gcc tgc atc atc ctg gtg 672 Gly Ala Leu Ala Phe Ile Thr Ala Ser Tyr Ala Cys Ile Ile Leu Val 210 215 220 gtc ctc cgg atc ccc tca gcc aag ggc agg tgg aaa acc ttt tct acc 720 Val Leu Arg Ile Pro Ser Ala Lys Gly Arg Trp Lys Thr Phe Ser Thr 225 230 235 240 tgc ggc tcc cac ctc act gtg gtg gcc ata ttc tat ggc acc ctc agt 768 Cys Gly Ser His Leu Thr Val Val Ala Ile Phe Tyr Gly Thr Leu Ser 245 250 255 tgg gtc tac ttc cgg ccc ctt tcc agc tat tca gtg acc aag ggt cgc 816 Trp Val Tyr Phe Arg Pro Leu Ser Ser Tyr Ser Val Thr Lys Gly Arg 260 265 270 att ata aca gtc gtg tac aca gtg gtg act ccc atg ctg aac ccc ttc 864 Ile Ile Thr Val Val Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 atc tac agc ctg agg aat ggg gat gtc aag gga ggc ttc atg aaa tgg 912 Ile Tyr Ser Leu Arg Asn Gly Asp Val Lys Gly Gly Phe Met Lys Trp 290 295 300 atg agc aga atg cag act ttt ttc ttt aga taa 945 Met Ser Arg Met Gln Thr Phe Phe Phe Arg 305 310 315 <210> 522 <211> 314 <212> PRT <213> Homo sapiens <400> 522 Met Asp Asn Ser Asn Trp Thr Ser Val Ser His Phe Val Leu Leu Gly 1 5 10 15 Ile Ser Thr His Pro Glu Glu Gln Ile Pro Leu Phe Leu Val Phe Ser 20 25 30 Leu Met Tyr Ala Ile Asn Ile Ser Gly Asn Leu Ala Ile Ile Thr Leu 35 40 45 Ile Leu Ser Ala Pro Arg Leu His Ile Pro Met Tyr Ile Phe Leu Ser 50 55 60 Asn Leu Ala Leu Thr Asp Ile Cys Phe Thr Ser Thr Thr Val Pro Lys 65 70 75 80 Met Leu Gln Ile Ile Phe Ser Pro Thr Lys Val Ile Ser Tyr Thr Gly 85 90 95 Cys Leu Ala Gln Thr Tyr Phe Phe Ile Cys Phe Ala Val Met Glu Asn 100 105 110 Phe Ile Leu Ala Val Met Ala Tyr Asp Arg Tyr Ile Ala Ile Cys His 115 120 125 Pro Phe His Tyr Thr Met Ile Leu Thr Arg Met Leu Cys Val Lys Met 130 135 140 Val Val Met Cys His Ala Leu Ser His Leu His Ala Met Leu His Thr 145 150 155 160 Phe Leu Ile Gly Gln Leu Ile Phe Cys Ala Asp Asn Arg Ile Pro His 165 170 175 Phe Phe Cys Asp Leu Tyr Ala Leu Met Lys Ile Ser Cys Thr Ser Thr 180 185 190 Tyr Leu Asn Thr Leu Met Ile His Thr Glu Gly Ala Val Val Ile Ser 195 200 205 Gly Ala Leu Ala Phe Ile Thr Ala Ser Tyr Ala Cys Ile Ile Leu Val 210 215 220 Val Leu Arg Ile Pro Ser Ala Lys Gly Arg Trp Lys Thr Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Thr Val Val Ala Ile Phe Tyr Gly Thr Leu Ser 245 250 255 Trp Val Tyr Phe Arg Pro Leu Ser Ser Tyr Ser Val Thr Lys Gly Arg 260 265 270 Ile Ile Thr Val Val Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Gly Asp Val Lys Gly Gly Phe Met Lys Trp 290 295 300 Met Ser Arg Met Gln Thr Phe Phe Phe Arg 305 310 <210> 523 <211> 843 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(843) <400> 523 atg tac ctg acc acg gtg ctg ggg aac ctg ctc atc atg ctg ctc atc 48 Met Tyr Leu Thr Thr Val Leu Gly Asn Leu Leu Ile Met Leu Leu Ile 1 5 10 15 cag ctg gac tct cac ctt cac acc ccc atg tac ttc ttc ctc agc cac 96 Gln Leu Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser His 20 25 30 ttg gct ctc act tat ttt tcc ttt tca tct gtc act gtc cct aag atg 144 Leu Ala Leu Thr Tyr Phe Ser Phe Ser Ser Val Thr Val Pro Lys Met 35 40 45 ctg atg gac atg cgg act aag tac aaa tcg atc ctc tat gag gaa tgc 192 Leu Met Asp Met Arg Thr Lys Tyr Lys Ser Ile Leu Tyr Glu Glu Cys 50 55 60 att tct cag atg tat ttt ttt ata ttt ttt act gac ctg gac agc ttc 240 Ile Ser Gln Met Tyr Phe Phe Ile Phe Phe Thr Asp Leu Asp Ser Phe 65 70 75 80 ctt att aca tca atg gca tat gac cga tat gtt gcc ata tgt cac cct 288 Leu Ile Thr Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His Pro 85 90 95 ctc cac tac act gtc atc atg agg gaa gag ctc tgt gtc ttc tta gtg 336 Leu His Tyr Thr Val Ile Met Arg Glu Glu Leu Cys Val Phe Leu Val 100 105 110 gct gta tct tgg att ctg tct tgt gcc agc tcc ctc tct cac acc ctt 384 Ala Val Ser Trp Ile Leu Ser Cys Ala Ser Ser Leu Ser His Thr Leu 115 120 125 ctc ctg acc cgg ctg tct ttc tgt gct gcg aac acc atc ccc cat gtc 432 Leu Leu Thr Arg Leu Ser Phe Cys Ala Ala Asn Thr Ile Pro His Val 130 135 140 ttc tgt gac ctt gct gcc ctg ctc aag ctg tcc tgc tca gat atc ttc 480 Phe Cys Asp Leu Ala Ala Leu Leu Lys Leu Ser Cys Ser Asp Ile Phe 145 150 155 160 ctc aat gag ctg gtc atg ttc aca gta ggg gtg gtg gtc att acc ctg 528 Leu Asn Glu Leu Val Met Phe Thr Val Gly Val Val Val Ile Thr Leu 165 170 175 cca ttc atg tgt atc ctg gta tca tat ggc tac att ggg gcc acc atc 576 Pro Phe Met Cys Ile Leu Val Ser Tyr Gly Tyr Ile Gly Ala Thr Ile 180 185 190 ctg agg gtc cct tca acc aaa ggg atc cac aaa gca ttg tcc aca tgt 624 Leu Arg Val Pro Ser Thr Lys Gly Ile His Lys Ala Leu Ser Thr Cys 195 200 205 ggc tcc cat ctc tct gtg gtg tct ctc tat tat ggg tca ata ttt ggc 672 Gly Ser His Leu Ser Val Val Ser Leu Tyr Tyr Gly Ser Ile Phe Gly 210 215 220 cag tac ctt ttc ccg act gta agc agt tct att gac aag gat gtc att 720 Gln Tyr Leu Phe Pro Thr Val Ser Ser Ser Ile Asp Lys Asp Val Ile 225 230 235 240 gtg gct ctc atg tac acg gtg gtc aca ccc atg ttg aac ccc ttt atc 768 Val Ala Leu Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe Ile 245 250 255 tac ngc att ngg aac agg gac atg aaa gag gcc ctt ggg aaa ctc ttc 816 Tyr Xaa Ile Xaa Asn Arg Asp Met Lys Glu Ala Leu Gly Lys Leu Phe 260 265 270 agt aga gca aca ttt ttc tct tgg tga 843 Ser Arg Ala Thr Phe Phe Ser Trp 275 280 <210> 524 <211> 280 <212> PRT <213> Homo sapiens <400> 524 Met Tyr Leu Thr Thr Val Leu Gly Asn Leu Leu Ile Met Leu Leu Ile 1 5 10 15 Gln Leu Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser His 20 25 30 Leu Ala Leu Thr Tyr Phe Ser Phe Ser Ser Val Thr Val Pro Lys Met 35 40 45 Leu Met Asp Met Arg Thr Lys Tyr Lys Ser Ile Leu Tyr Glu Glu Cys 50 55 60 Ile Ser Gln Met Tyr Phe Phe Ile Phe Phe Thr Asp Leu Asp Ser Phe 65 70 75 80 Leu Ile Thr Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His Pro 85 90 95 Leu His Tyr Thr Val Ile Met Arg Glu Glu Leu Cys Val Phe Leu Val 100 105 110 Ala Val Ser Trp Ile Leu Ser Cys Ala Ser Ser Leu Ser His Thr Leu 115 120 125 Leu Leu Thr Arg Leu Ser Phe Cys Ala Ala Asn Thr Ile Pro His Val 130 135 140 Phe Cys Asp Leu Ala Ala Leu Leu Lys Leu Ser Cys Ser Asp Ile Phe 145 150 155 160 Leu Asn Glu Leu Val Met Phe Thr Val Gly Val Val Val Ile Thr Leu 165 170 175 Pro Phe Met Cys Ile Leu Val Ser Tyr Gly Tyr Ile Gly Ala Thr Ile 180 185 190 Leu Arg Val Pro Ser Thr Lys Gly Ile His Lys Ala Leu Ser Thr Cys 195 200 205 Gly Ser His Leu Ser Val Val Ser Leu Tyr Tyr Gly Ser Ile Phe Gly 210 215 220 Gln Tyr Leu Phe Pro Thr Val Ser Ser Ser Ile Asp Lys Asp Val Ile 225 230 235 240 Val Ala Leu Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe Ile 245 250 255 Tyr Xaa Ile Xaa Asn Arg Asp Met Lys Glu Ala Leu Gly Lys Leu Phe 260 265 270 Ser Arg Ala Thr Phe Phe Ser Trp 275 280 <210> 525 <211> 975 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(975) <400> 525 atg gga atg tcc aac ctg aca aga ctc tct gaa ttt att ctc ttg gga 48 Met Gly Met Ser Asn Leu Thr Arg Leu Ser Glu Phe Ile Leu Leu Gly 1 5 10 15 ctc tcc tct cgg tct gaa gac cag agg cca ctc ttt gcc ctc ttt ctt 96 Leu Ser Ser Arg Ser Glu Asp Gln Arg Pro Leu Phe Ala Leu Phe Leu 20 25 30 atc ata tac ctg gtc act ttg atg gga aat ctg ctc atc atc ttg gct 144 Ile Ile Tyr Leu Val Thr Leu Met Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 atc cac tct gat cct cga ctt caa aac cct atg tat ttt ttc cta agc 192 Ile His Ser Asp Pro Arg Leu Gln Asn Pro Met Tyr Phe Phe Leu Ser 50 55 60 atc ttg tcc ttt gct gat att tgc tac aca aca gtc ata gtc cca aag 240 Ile Leu Ser Phe Ala Asp Ile Cys Tyr Thr Thr Val Ile Val Pro Lys 65 70 75 80 atg ctc gtg aac ttc tta tca gag aaa aag acc att tcc tat gct gaa 288 Met Leu Val Asn Phe Leu Ser Glu Lys Lys Thr Ile Ser Tyr Ala Glu 85 90 95 tgt ctg gca cag atg tat ttc ttc ctg gtt ttt gga aac ata gat agt 336 Cys Leu Ala Gln Met Tyr Phe Phe Leu Val Phe Gly Asn Ile Asp Ser 100 105 110 tat ctc ctg gcg gct atg gcc atc aac cgc tgt gta gcc att tgt aac 384 Tyr Leu Leu Ala Ala Met Ala Ile Asn Arg Cys Val Ala Ile Cys Asn 115 120 125 cca ttc cat tat gtc act gtt atg aac cgc aga tgc tgt gtg ttg cta 432 Pro Phe His Tyr Val Thr Val Met Asn Arg Arg Cys Cys Val Leu Leu 130 135 140 cta gca ttc ccc atc act ttc tcc tat ttc cac tct ctc cta cat gtc 480 Leu Ala Phe Pro Ile Thr Phe Ser Tyr Phe His Ser Leu Leu His Val 145 150 155 160 ctc ctg gtg aat cgg ctc acc ttt tgt aca tca aat gtt atc cat cat 528 Leu Leu Val Asn Arg Leu Thr Phe Cys Thr Ser Asn Val Ile His His 165 170 175 ttt ttt tgt gat gtc aac cct gtg ctg aaa ctg tcc tgc tcc tcc acc 576 Phe Phe Cys Asp Val Asn Pro Val Leu Lys Leu Ser Cys Ser Ser Thr 180 185 190 ttt gtc aat gaa att gtg gcc atg aca gaa ggg ctg gcc tct gtg atg 624 Phe Val Asn Glu Ile Val Ala Met Thr Glu Gly Leu Ala Ser Val Met 195 200 205 gct cca ttt gtc tgt atc atc atc tct tat cta aga att ctc atc gct 672 Ala Pro Phe Val Cys Ile Ile Ile Ser Tyr Leu Arg Ile Leu Ile Ala 210 215 220 gtt ctc aag att ccc tca gca gct gga aaa cac aaa gcc ttc tcc acc 720 Val Leu Lys Ile Pro Ser Ala Ala Gly Lys His Lys Ala Phe Ser Thr 225 230 235 240 tgc agc tcc cat ctc act gtg gtg att ctg ttt tat ggg agt att agc 768 Cys Ser Ser His Leu Thr Val Val Ile Leu Phe Tyr Gly Ser Ile Ser 245 250 255 tat gtc tat ttg cag cct ttg tcc agc tat act gtc aag gac cga ata 816 Tyr Val Tyr Leu Gln Pro Leu Ser Ser Tyr Thr Val Lys Asp Arg Ile 260 265 270 gca aca atc aac tac act gtg ttg aca tca gtg ttg aac cca ttt atc 864 Ala Thr Ile Asn Tyr Thr Val Leu Thr Ser Val Leu Asn Pro Phe Ile 275 280 285 tac agt tta aga aac aaa gac atg aaa cgg ggc tta cag aaa ttg ata 912 Tyr Ser Leu Arg Asn Lys Asp Met Lys Arg Gly Leu Gln Lys Leu Ile 290 295 300 aac aag att aag tct caa atg agt agg ttc tct aca aag acc aat aaa 960 Asn Lys Ile Lys Ser Gln Met Ser Arg Phe Ser Thr Lys Thr Asn Lys 305 310 315 320 atc tgt gga ccc tga 975 Ile Cys Gly Pro 325 <210> 526 <211> 324 <212> PRT <213> Homo sapiens <400> 526 Met Gly Met Ser Asn Leu Thr Arg Leu Ser Glu Phe Ile Leu Leu Gly 1 5 10 15 Leu Ser Ser Arg Ser Glu Asp Gln Arg Pro Leu Phe Ala Leu Phe Leu 20 25 30 Ile Ile Tyr Leu Val Thr Leu Met Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Ile His Ser Asp Pro Arg Leu Gln Asn Pro Met Tyr Phe Phe Leu Ser 50 55 60 Ile Leu Ser Phe Ala Asp Ile Cys Tyr Thr Thr Val Ile Val Pro Lys 65 70 75 80 Met Leu Val Asn Phe Leu Ser Glu Lys Lys Thr Ile Ser Tyr Ala Glu 85 90 95 Cys Leu Ala Gln Met Tyr Phe Phe Leu Val Phe Gly Asn Ile Asp Ser 100 105 110 Tyr Leu Leu Ala Ala Met Ala Ile Asn Arg Cys Val Ala Ile Cys Asn 115 120 125 Pro Phe His Tyr Val Thr Val Met Asn Arg Arg Cys Cys Val Leu Leu 130 135 140 Leu Ala Phe Pro Ile Thr Phe Ser Tyr Phe His Ser Leu Leu His Val 145 150 155 160 Leu Leu Val Asn Arg Leu Thr Phe Cys Thr Ser Asn Val Ile His His 165 170 175 Ph e Phe Cys Asp Val Asn Pro Val Leu Lys Leu Ser Cys Ser Ser Thr 180 185 190 Phe Val Asn Glu Ile Val Ala Met Thr Glu Gly Leu Ala Ser Val Met 195 200 205 Ala Pro Phe Val Cys Ile Ile Ile Ser Tyr Leu Arg Ile Leu Ile Ala 210 215 220 Val Leu Lys Ile Pro Ser Ala Ala Gly Lys His Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Leu Thr Val Val Ile Leu Phe Tyr Gly Ser Ile Ser 245 250 255 Tyr Val Tyr Leu Gln Pro Leu Ser Ser Tyr Thr Val Lys Asp Arg Ile 260 265 270 Ala Thr Ile Asn Tyr Thr Val Leu Thr Ser Val Leu Asn Pro Phe Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Asp Met Lys Arg Gly Leu Gln Lys Leu Ile 290 295 300 Asn Lys Ile Lys Ser Gln Met Ser Arg Phe Ser Thr Lys Thr Asn Lys 305 310 315 320 Ile Cys Gly Pro <210> 527 <211> 942 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(942) <400> 527 atg aag agg gag aat cag agc agt gtg tct gag ttc ctc ctc ctg gac 48 Met Lys Arg Glu Asn Gln Ser Ser Val Ser Glu Phe Leu Leu Leu Asp 1 5 10 15 ctc ccc atc tgg cca gag cag cag gct gtg ttc ttc acc ctg ttc ttg 96 Leu Pro Ile Trp Pro Glu Gln Gln Ala Val Phe Phe Thr Leu Phe Leu 20 25 30 ggc atg tac ctg atc acg gtg ctg ggg aac ctg ctc atc atc ctg ctc 144 Gly Met Tyr Leu Ile Thr Val Leu Gly Asn Leu Leu Ile Ile Leu Leu 35 40 45 atc cgg ctg gac tct cac ctt cac acc ccc atg ttc ttc ttc ctc agc 192 Ile Arg Leu Asp Ser His Leu His Thr Pro Met Phe Phe Phe Leu Ser 50 55 60 cac ttg gct ctc act gac atc tcc ctt tca tct gtc act gtc cca aag 240 His Leu Ala Leu Thr Asp Ile Ser Leu Ser Ser Val Thr Val Pro Lys 65 70 75 80 atg tta tta agc atg caa act cag gat caa tcc att ctt tat gca ggg 288 Met Leu Leu Ser Met Gln Thr Gln Asp Gln Ser Ile Leu Tyr Ala Gly 85 90 95 tgt gta act cag atg tat ttt ttc ata ttt ttc act gat cta gac aat 336 Cys Val Thr Gln Met Tyr Phe Phe Ile Phe Phe Thr Asp Leu Asp Asn 100 105 110 ttc ctt ctc act tca atg gca tac gat cgg tat gtg gcc atc tgt cac 384 Phe Leu Leu Thr Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 ccc ctc cgc tac acc act atc atg aaa gag gga ctg tgt aac tta cta 432 Pro Leu Arg Tyr Thr Thr Ile Met Lys Glu Gly Leu Cys Asn Leu Leu 130 135 140 gtc act gtg tcc tgg atc ctc tcc tgt acc aat gcc ctg tct cac act 480 Val Thr Val Ser Trp Ile Leu Ser Cys Thr Asn Ala Leu Ser His Thr 145 150 155 160 ctc ctc ctg gcc cag ctg tcc ttt tgt gct gac aac acc atc ccc cat 528 Leu Leu Leu Ala Gln Leu Ser Phe Cys Ala Asp Asn Thr Ile Pro His 165 170 175 ttc ttc tgt gat ctt gtt gcc cta ctc aag ctc tca tgc tca gac atc 576 Phe Phe Cys Asp Leu Val Ala Leu Leu Lys Leu Ser Cys Ser Asp Ile 180 185 190 tcc ctc aat gag ctg gtc att ttc aca gtg gga cag gca gtc att act 624 Ser Leu Asn Glu Leu Val Ile Phe Thr Val Gly Gln Ala Val Ile Thr 195 200 205 cta cca cta ata tgc atc ttg atc tct tat ggc cac att ggg gtc acc 672 Leu Pro Leu Ile Cys Ile Leu Ile Ser Tyr Gly His Ile Gly Val Thr 210 215 220 atc ctc aag gct cca tct act aag ggc atc ttc aaa gct ttg tcc acc 720 Ile Leu Lys Ala Pro Ser Thr Lys Gly Ile Phe Lys Ala Leu Ser Thr 225 230 235 240 tgt ggc tct cac ctc tct gtg gtg tct ctg tat tat ggc aca att att 768 Cys Gly Ser His Leu Ser Val Val Ser Leu Tyr Tyr Gly Thr Ile Ile 245 250 255 gga ctg tat ttt ctc ccc tca tcc agt gcc tcc agt gac aag gac gta 816 Gly Leu Tyr Phe Leu Pro Ser Ser Ser Ala Ser Ser Asp Lys Asp Val 260 265 270 att gcc tct gtg atg tac acg gtg atc acc cca ttg ctg aat ccc ttc 864 Ile Ala Ser Val Met Tyr Thr Val Ile Thr Pro Leu Leu Asn Pro Phe 275 280 285 att tat agc cta agg aac agg gac ata aag gga gcc ctg gag aga ctc 912 Ile Tyr Ser Leu Arg Asn Arg Asp Ile Lys Gly Ala Leu Glu Arg Leu 290 295 300 ttc aac agg gca aca gtc tta tct caa tga 942 Phe Asn Arg Ala Thr Val Leu Ser Gln 305 310 <210> 528 <211> 313 <212> PRT <213> Homo sapiens <400> 528 Met Lys Arg Glu Asn Gln Ser Ser Val Ser Glu Phe Leu Leu Leu Asp 1 5 10 15 Leu Pro Ile Trp Pro Glu Gln Gln Ala Val Phe Phe Thr Leu Phe Leu 20 25 30 Gly Met Tyr Leu Ile Thr Val Leu Gly Asn Leu Leu Ile Ile Leu Leu 35 40 45 Ile Arg Leu Asp Ser His Leu His Thr Pro Met Phe Phe Phe Leu Ser 50 55 60 His Leu Ala Leu Thr Asp Ile Ser Leu Ser Ser Val Thr Val Pro Lys 65 70 75 80 Met Leu Leu Ser Met Gln Thr Gln Asp Gln Ser Ile Leu Tyr Ala Gly 85 90 95 Cys Val Thr Gln Met Tyr Phe Phe Ile Phe Phe Thr Asp Leu Asp Asn 100 105 110 Phe Leu Leu Thr Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu Arg Tyr Thr Thr Ile Met Lys Glu Gly Leu Cys Asn Leu Leu 130 135 140 Val Thr Val Ser Trp Ile Leu Ser Cys Thr Asn Ala Leu Ser His Thr 145 150 155 160 Leu Leu Leu Ala Gln Leu Ser Phe Cys Ala Asp Asn Thr Ile Pro His 165 170 175 Phe Phe Cys Asp Leu Val Ala Leu Leu Lys Leu Ser Cys Ser Asp Ile 180 185 190 Ser Leu Asn Glu Leu Val Ile Phe Thr Val Gly Gln Ala Val Ile Thr 195 200 205 Leu Pro Leu Ile Cys Ile Leu Ile Ser Tyr Gly His Ile Gly Val Thr 210 215 220 Ile Leu Lys Ala Pro Ser Thr Lys Gly Ile Phe Lys Ala Leu Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ser Val Val Ser Leu Tyr Tyr Gly Thr Ile Ile 245 250 255 Gly Leu Tyr Phe Leu Pro Ser Ser Ser Ala Ser Ser Asp Lys Asp Val 260 265 270 Ile Ala Ser Val Met Tyr Thr Val Ile Thr Pro Leu Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Ile Lys Gly Ala Leu Glu Arg Leu 290 295 300 Phe Asn Arg Ala Thr Val Leu Ser Gln 305 310 <210> 529 <211> 858 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(858) <400> 529 atg tat gtg gtc atc ctt ctg ggg aat ggt act ctc att tta atc agc 48 Met Tyr Val Val Ile Leu Leu Gly Asn Gly Thr Leu Ile Leu Ile Ser 1 5 10 15 atc ttg gac cct cac ctt cac acc cct atg tac ttc ttt ctg ggg aac 96 Ile Leu Asp Pro His Leu His Thr Pro Met Tyr Phe Phe Leu Gly Asn 20 25 30 ctc tcc ttc ttg gac atc tgc tac acc acc acc tct att ccc tcc acg 144 Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Thr Ser Ile Pro Ser Thr 35 40 45 cta gtg agc ttc ctt tca gaa aga aag acc att tcc ctt tct ggc tgt 192 Leu Val Ser Phe Leu Ser Glu Arg Lys Thr Ile Ser Leu Ser Gly Cys 50 55 60 gca gtg cag atg ttc ctc agc ttg gcc atg ggg aca aca gag tgt gtg 240 Ala Val Gln Met Phe Leu Ser Leu Ala Met Gly Thr Thr Glu Cys Val 65 70 75 80 ctt ctg ggc gtg atg gcc ttt gac cgc tat gtg gct atc tgc aac cct 288 Leu Leu Gly Val Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn Pro 85 90 95 ctg aga tat ccc atc atc atg agt aag gat gcc tat gta ccc atg gca 336 Leu Arg Tyr Pro Ile Ile Met Ser Lys Asp Ala Tyr Val Pro Met Ala 100 105 110 gct ggg tcc tgg atc ata gga gct gtc aat tct gca gta caa aca gtg 384 Ala Gly Ser Trp Ile Ile Gly Ala Val Asn Ser Ala Val Gln Thr Val 115 120 125 ttt gtg gta caa ttg cct ttc tgc agg aat aac atc atc aat cat ttc 432 Phe Val Val Gln Leu Pro Phe Cys Arg Asn Asn Ile Ile Asn His Phe 130 135 140 acc tgt gaa att cta gct gtc atg aaa ctg gcc tgt gct gac atc tca 480 Thr Cys Glu Ile Leu Ala Val Met Lys Leu Ala Cys Ala Asp Ile Ser 145 150 155 160 ggc aat gag ttc atc ctg ctt gtg acc aca aca ttg ttc cta ttg aca 528 Gly Asn Glu Phe Ile Leu Leu Val Thr Thr Thr Leu Phe Leu Leu Thr 165 170 175 cct ttg tta tta att att gtc tct tac acg tta atc att ttg agc atc 576 Pro Leu Leu Leu Ile Ile Val Ser Tyr Thr Leu Ile Ile Leu Ser Ile 180 185 190 ttc aaa att agc tct tcg gag ggg aga agc aaa cct tcc tct acc tgc 624 Phe Lys Ile Ser Ser Ser Glu Gly Arg Ser Lys Pro Ser Ser Thr Cys 195 200 205 tca gct cgt ctg act gtg gtg ata aca ttc tgt ggg acc atc ttc ctc 672 Ser Ala Arg Leu Thr Val Val Ile Thr Phe Cys Gly Thr Ile Phe Leu 210 215 220 atg tac atg aag ccc aag tct caa gag aca ctt aat tca gat gac ttg 720 Met Tyr Met Lys Pro Lys Ser Gln Glu Thr Leu Asn Ser Asp Asp Leu 225 230 235 240 gat gcc act gac aaa ctt ata ttc ata ttc tac agg gtg atg act ccc 768 Asp Ala Thr Asp Lys Leu Ile Phe Ile Phe Tyr Arg Val Met Thr Pro 245 250 255 atg atg aat cct tta atc tac agt ctt aga aac aag gat gtg aag gag 816 Met Met Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu 260 265 270 gca gta aaa cac cta ctg aga aga aaa aat ttt aac aag taa 858 Ala Val Lys His Leu Leu Arg Arg Lys Asn Phe Asn Lys 275 280 285 <210> 530 <211> 285 <212> PRT <213> Homo sapiens <400> 530 Met Tyr Val Val Ile Leu Leu Gly Asn Gly Thr Leu Ile Leu Ile Ser 1 5 10 15 Ile Leu Asp Pro His Leu His Thr Pro Met Tyr Phe Phe Leu Gly Asn 20 25 30 Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Thr Ser Ile Pro Ser Thr 35 40 45 Leu Val Ser Phe Leu Ser Glu Arg Lys Thr Ile Ser Leu Ser Gly Cys 50 55 60 Ala Val Gln Met Phe Leu Ser Leu Ala Met Gly Thr Thr Glu Cys Val 65 70 75 80 Leu Leu Gly Val Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn Pro 85 90 95 Leu Arg Tyr Pro Ile Ile Met Ser Lys Asp Ala Tyr Val Pro Met Ala 100 105 110 Ala Gly Ser Trp Ile Ile Gly Ala Val Asn Ser Ala Val Gln Thr Val 115 120 125 Phe Val Val Gln Leu Pro Phe Cys Arg Asn Asn Ile Ile Asn His Phe 130 135 140 Thr Cys Glu Ile Leu Ala Val Met Lys Leu Ala Cys Ala Asp Ile Ser 145 150 155 160 Gly Asn Glu Phe Ile Leu Leu Val Thr Thr Thr Leu Phe Leu Leu Thr 165 170 175 Pro Leu Leu Leu Ile Ile Val Ser Tyr Thr Leu Ile Ile Leu Ser Ile 180 185 190 Phe Lys Ile Ser Ser Ser Glu Gly Arg Ser Lys Pro Ser Ser Thr Cys 195 200 205 Ser Ala Arg Leu Thr Val Val Ile Thr Phe Cys Gly Thr Ile Phe Leu 210 215 220 Met Tyr Met Lys Pro Lys Ser Gln Glu Thr Leu Asn Ser Asp Asp Leu 225 230 235 240 Asp Ala Thr Asp Lys Leu Ile Phe Ile Phe Tyr Arg Val Met Thr Pro 245 250 255 Met Met Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu 260 265 270 Ala Val Lys His Leu Leu Arg Arg Lys Asn Phe Asn Lys 275 280 285 <210> 531 <211> 957 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(957) <400> 531 atg gac aag ata aac cag aca ttt gtg aga gaa ttc att ctt ctg gga 48 Met Asp Lys Ile Asn Gln Thr Phe Val Arg Glu Phe Ile Leu Leu Gly 1 5 10 15 ctc tct ggt tac ccc aaa ctt gag atc att ttc ttt gct ctg att cta 96 Leu Ser Gly Tyr Pro Lys Leu Glu Ile Ile Phe Phe Ala Leu Ile Leu 20 25 30 gtt atg tac gta gtg att cta att ggc aat ggt gtt ctg atc ata gca 144 Val Met Tyr Val Val Ile Leu Ile Gly Asn Gly Val Leu Ile Ile Ala 35 40 45 agc atc ttg gat tct cgt ctt cac atg ccc atg tac ttc ttc ctg ggc 192 Ser Ile Leu Asp Ser Arg Leu His Met Pro Met Tyr Phe Phe Leu Gly 50 55 60 aac ctc tct ttc ctg gat atc tgc tat aca acc tcc tcc att ccc tca 240 Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Ser Ser Ile Pro Ser 65 70 75 80 aca ctg gtg agc tta atc tca aag aaa aga aac att tcc ttc tct gga 288 Thr Leu Val Ser Leu Ile Ser Lys Lys Arg Asn Ile Ser Phe Ser Gly 85 90 95 tgt gca gtg cag atg ttc ttt ggg ttt gca atg ggg tca aca gaa tgt 336 Cys Ala Val Gln Met Phe Phe Gly Phe Ala Met Gly Ser Thr Glu Cys 100 105 110 ttc ctc ctt ggc atg atg gca ttt gat cgt tat gtg gcc atc tgt aac 384 Phe Leu Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 cct ctg aga tac ccc atc atc atg aac aag gtg gtg tat gta ctg ctg 432 Pro Leu Arg Tyr Pro Ile Ile Met Asn Lys Val Val Tyr Val Leu Leu 130 135 140 act tct gta tca tgg ctt tct ggt gga atc aat tca act gtg caa aca 480 Thr Ser Val Ser Trp Leu Ser Gly Gly Ile Asn Ser Thr Val Gln Thr 145 150 155 160 tca ctt gcc atg cga tgg cct ttc tgt ggg aac aat att att aat cat 528 Ser Leu Ala Met Arg Trp Pro Phe Cys Gly Asn Asn Ile Ile Asn His 165 170 175 ttc tta tgc gag atc tta gct gtc cta aaa tta gct tgt tct gat ata 576 Phe Leu Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Ser Asp Ile 180 185 190 tct gtc aat att gtt acc cta gca gtg tca aat att gct ttc cta gtt 624 Ser Val Asn Ile Val Thr Leu Ala Val Ser Asn Ile Ala Phe Leu Val 195 200 205 ctt cct ctg ctc gtg att ttt ttc tcc tat atg ttc atc ctc tac acc 672 Leu Pro Leu Leu Val Ile Phe Phe Ser Tyr Met Phe Ile Leu Tyr Thr 210 215 220 atc ttg cga acg aac tcg gcc aca gga aga cac aag gca ttt tct aca 720 Ile Leu Arg Thr Asn Ser Ala Thr Gly Arg His Lys Ala Phe Ser Thr 225 230 235 240 tgc tca gct cac ctg act gtg gtg atc ata ttt tat ggt acc atc ttc 768 Cys Ser Ala His Leu Thr Val Val Ile Ile Phe Tyr Gly Thr Ile Phe 245 250 255 ttt atg tat gca aaa cct aag tcc cag gac ctc ctt ggg aaa gac aac 816 Phe Met Tyr Ala Lys Pro Lys Ser Gln Asp Leu Leu Gly Lys Asp Asn 260 265 270 ttg caa gct aca gag ggg ctt gtt tcc atg ttt tat ggg gtt gtg acc 864 Leu Gln Ala Thr Glu Gly Leu Val Ser Met Phe Tyr Gly Val Val Thr 275 280 285 ccc atg tta aac ccc ata atc tat agc ttg aga aat aaa gat gta aaa 912 Pro Met Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys 290 295 300 gct gct ata aaa tat ttg ctg agc agg aaa gct att aac cag taa 957 Ala Ala Ile Lys Tyr Leu Leu Ser Arg Lys Ala Ile Asn Gln 305 310 315 <210> 532 <211> 318 <212> PRT <213> Homo sapiens <400> 532 Met Asp Lys Ile Asn Gln Thr Phe Val Arg Glu Phe Ile Leu Leu Gly 1 5 10 15 Leu Ser Gly Tyr Pro Lys Leu Glu Ile Ile Phe Phe Ala Leu Ile Leu 20 25 30 Val Met Tyr Val Val Ile Leu Ile Gly Asn Gly Val Leu Ile Ile Ala 35 40 45 Ser Ile Leu Asp Ser Arg Leu His Met Pro Met Tyr Phe Phe Leu Gly 50 55 60 Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Ser Ser Ile Pro Ser 65 70 75 80 Thr Leu Val Ser Leu Ile Ser Lys Lys Arg Asn Ile Ser Phe Ser Gly 85 90 95 Cys Ala Val Gln Met Phe Phe Gly Phe Ala Met Gly Ser Thr Glu Cys 100 105 110 Phe Leu Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Pro Ile Ile Met Asn Lys Val Val Tyr Val Leu Leu 130 135 140 Thr Ser Val Ser Trp Leu Ser Gly Gly Ile Asn Ser Thr Val Gln Thr 145 150 155 160 Ser Leu Ala Met Arg Trp Pro Phe Cys Gly Asn Asn Ile Ile Asn His 165 170 175 Phe Leu Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Ser Asp Ile 180 185 190 Ser Val Asn Ile Val Thr Leu Ala Val Ser Asn Ile Ala Phe Leu Val 195 200 205 Leu Pro Leu Leu Val Ile Phe Phe Ser Tyr Met Phe Ile Leu Tyr Thr 210 215 220 Ile Leu Arg Thr Asn Ser Ala Thr Gly Arg His Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ala His Leu Thr Val Val Ile Ile Phe Tyr Gly Thr Ile Phe 245 250 255 Phe Met Tyr Ala Lys Pro Lys Ser Gln Asp Leu Leu Gly Lys Asp Asn 260 265 270 Leu Gln Ala Thr Glu Gly Leu Val Ser Met Phe Tyr Gly Val Val Thr 275 280 285 Pro Met Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys 290 295 300 Ala Ala Ile Lys Tyr Leu Leu Ser Arg Lys Ala Ile Asn Gln 305 310 315 <210> 533 <211> 858 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(858) <400> 533 atg tat gtg gtc atc ctt ctg ggg aat ggt act ctc att tta atc agc 48 Met Tyr Val Val Ile Leu Leu Gly Asn Gly Thr Leu Ile Leu Ile Ser 1 5 10 15 atc ttg gac cct cac ctt cac acc cct atg tac ttc ttt ctg ggg aac 96 Ile Leu Asp Pro His Leu His Thr Pro Met Tyr Phe Phe Leu Gly Asn 20 25 30 ctc tcc ttc ttg gac atc tgc tac acc acc acc tct att ccc tcc acg 144 Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Thr Ser Ile Pro Ser Thr 35 40 45 cta gtg agc ttc ctt tca gaa aga aag acc att tcc ctt tct ggc tgt 192 Leu Val Ser Phe Leu Ser Glu Arg Lys Thr Ile Ser Leu Ser Gly Cys 50 55 60 gca gtg cag atg ttc ctc ggc ttg gcc atg ggg aca aca gag tgt gtg 240 Ala Val Gln Met Phe Leu Gly Leu Ala Met Gly Thr Thr Glu Cys Val 65 70 75 80 ctt ctg ggc atg atg gcc ttt gac cgc tat gtg gct atc tgc aac cct 288 Leu Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn Pro 85 90 95 ctg aga tat ccc atc atc atg agt aag gat gcc tat gta ccc atg gca 336 Leu Arg Tyr Pro Ile Ile Met Ser Lys Asp Ala Tyr Val Pro Met Ala 100 105 110 gct ggg tcc tgg atc ata gga gct gtc aat tct gca gta caa tca gtg 384 Ala Gly Ser Trp Ile Ile Gly Ala Val Asn Ser Ala Val Gln Ser Val 115 120 125 ttt gtg gta caa ttg cct ttc tgc agg aat aac atc atc aat cat ttc 432 Phe Val Val Gln Leu Pro Phe Cys Arg Asn Asn Ile Ile Asn His Phe 130 135 140 acc tgt gaa att ctg gct gtc atg aaa ctg gcc tgt gct gac atc tca 480 Thr Cys Glu Ile Leu Ala Val Met Lys Leu Ala Cys Ala Asp Ile Ser 145 150 155 160 gac aat gag ttc atc atg ctt gtg gcc aca aca ttg ttc ata ttg aca 528 Asp Asn Glu Phe Ile Met Leu Val Ala Thr Thr Leu Phe Ile Leu Thr 165 170 175 cct ttg tta tta atc att gtc tct tac acg tta atc att gtg agc atc 576 Pro Leu Leu Leu Ile Ile Val Ser Tyr Thr Leu Ile Ile Val Ser Ile 180 185 190 ttc aaa att agc tct tcc gag ggg aga agc aaa gct tcc tct acc tgt 624 Phe Lys Ile Ser Ser Ser Glu Gly Arg Ser Lys Ala Ser Ser Thr Cys 195 200 205 tca gcc cat ctg act gtg gtc ata ata ttc tat ggg acc atc ctc ttc 672 Ser Ala His Leu Thr Val Val Ile Ile Phe Tyr Gly Thr Ile Leu Phe 210 215 220 atg tac atg aag ccc aag tct aaa gag aca ctt aat tcg gat gac ttg 720 Met Tyr Met Lys Pro Lys Ser Lys Glu Thr Leu Asn Ser Asp Asp Leu 225 230 235 240 gat gct acc gac aaa att ata tcc atg ttc tat ggg gtg atg act ccc 768 Asp Ala Thr Asp Lys Ile Ile Ser Met Phe Tyr Gly Val Met Thr Pro 245 250 255 atg atg aat cct tta atc tac agt ctt aga aac aag gat gtg aaa gag 816 Met Met Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu 260 265 270 gca gta aaa cac cta ctg aac aga agg ttc ttt agc aag tga 858 Ala Val Lys His Leu Leu Asn Arg Arg Phe Phe Ser Lys 275 280 285 <210> 534 <211> 285 <212> PRT <213> Homo sapiens <4 00> 534 Met Tyr Val Val Ile Leu Leu Gly Asn Gly Thr Leu Ile Leu Ile Ser 1 5 10 15 Ile Leu Asp Pro His Leu His Thr Pro Met Tyr Phe Phe Leu Gly Asn 20 25 30 Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Thr Ser Ile Pro Ser Thr 35 40 45 Leu Val Ser Phe Leu Ser Glu Arg Lys Thr Ile Ser Leu Ser Gly Cys 50 55 60 Ala Val Gln Met Phe Leu Gly Leu Ala Met Gly Thr Thr Glu Cys Val 65 70 75 80 Leu Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn Pro 85 90 95 Leu Arg Tyr Pro Ile Ile Met Ser Lys Asp Ala Tyr Val Pro Met Ala 100 105 110 Ala Gly Ser Trp Ile Ile Gly Ala Val Asn Ser Ala Val Gln Ser Val 115 120 125 Phe Val Val Gln Leu Pro Phe Cys Arg Asn Asn Ile Ile Asn His Phe 130 135 140 Thr Cys Glu Ile Leu Ala Val Met Lys Leu Ala Cys Ala Asp Ile Ser 145 150 155 160 Asp Asn Glu Phe Ile Met Leu Val Ala Thr Thr Leu Phe Ile Leu Thr 165 170 175 Pro Leu Leu Leu Ile Ile Val Ser Tyr Thr Leu Ile Ile Val Ser Ile 180 185 190 Phe Lys Ile Ser Ser Ser Glu Gly Arg Ser Lys Ala Ser Ser Thr Cys 195 200 205 Ser Ala His Leu Thr Val Val Ile Ile Phe Tyr Gly Thr Ile Leu Phe 210 215 220 Met Tyr Met Lys Pro Lys Ser Lys Glu Thr Leu Asn Ser Asp Asp Leu 225 230 235 240 Asp Ala Thr Asp Lys Ile Ile Ser Met Phe Tyr Gly Val Met Thr Pro 245 250 255 Met Met Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu 260 265 270 Ala Val Lys His Leu Leu Asn Arg Arg Phe Phe Ser Lys 275 280 285 <210> 535 <211> 1044 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1044) <400> 535 atg att gtt cag tta att tgt act gtt tgt ttc ttg gca gta aat aca 48 Met Ile Val Gln Leu Ile Cys Thr Val Cys Phe Leu Ala Val Asn Thr 1 5 10 15 ttt cat gtt aga tct tct ttt gat ttc ctg aaa gca gat gac atg ggt 96 Phe His Val Arg Ser Ser Phe Asp Phe Leu Lys Ala Asp Asp Met Gly 20 25 30 gag att aac cag aca ctt gtg tca gaa ttt ctt ctt ctg ggt ctt tct 144 Glu Ile Asn Gln Thr Leu Val Ser Glu Phe Leu Leu Leu Gly Leu Ser 35 40 45 gga tac cca aag att gag att gtt tac ttt gct ctc att cta gtt atg 192 Gly Tyr Pro Lys Ile Glu Ile Val Tyr Phe Ala Leu Ile Leu Val Met 50 55 60 tac cta gtg att cta att ggc aat ggt gtt cta atc ata gcc agc atc 240 Tyr Leu Val Ile Leu Ile Gly Asn Gly Val Leu Ile Ile Ala Ser Ile 65 70 75 80 ttt gat tct cat ttt cac aca cca atg tac ttc ttc ctg ggc aac ctc 288 Phe Asp Ser His Phe His Thr Pro Met Tyr Phe Phe Leu Gly Asn Leu 85 90 95 tct ttc ctg gat atc tgc tat aca tcc tcc tct gtt ccc tca aca ttg 336 Ser Phe Leu Asp Ile Cys Tyr Thr Ser Ser Ser Val Pro Ser Thr Leu 100 105 110 gtg agc tta atc tca aag aaa aga aac att tcc ttc tct gga tgt gca 384 Val Ser Leu Ile Ser Lys Lys Arg Asn Ile Ser Phe Ser Gly Cys Ala 115 120 125 gtg cag atg ttc ttt ggg ttt gca atg ggg tca aca gaa tgt ctg ctt 432 Val Gln Met Phe Phe Gly Phe Ala Met Gly Ser Thr Glu Cys Leu Leu 130 135 140 ctt ggc atg atg gca ttt gat cgt tat gtg gcc atc tgc aac cca ctg 480 Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn Pro Leu 145 150 155 160 aga tac ccc atc atc ctg agc aag gtg gcg tat gta ttg atg gct tct 528 Arg Tyr Pro Ile Ile Leu Ser Lys Val Ala Tyr Val Leu Met Ala Ser 165 170 175 gtg tcc tgg ctg tcc ggt gga ata aat tca gct gtg caa aca tta ctt 576 Val Ser Trp Leu Ser Gly Gly Ile Asn Ser Ala Val Gln Thr Leu Leu 180 185 190 gcc atg aga ctg cct ttc tgt ggg aat aat att atc aat cat ttc gca 624 Ala Met Arg Leu Pro Phe Cys Gly Asn Asn Ile Ile Asn His Phe Ala 195 200 205 tgt gaa ata tta gct gtc ctc aag ctg gcc tgt gct gat ata tcc ctc 672 Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Ala Asp Ile Ser Leu 210 215 220 aat att atc acc atg gtg ata tca aat atg gcc ttc ctg gtt ctt cca 720 Asn Ile Ile Thr Met Val Ile Ser Asn Met Ala Phe Leu Val Leu Pro 225 230 235 240 ctg atg gtc att ttt ttc tcc tat atg ttc atc ctc tac acc atc ttg 768 Leu Met Val Ile Phe Phe Ser Tyr Met Phe Ile Leu Tyr Thr Ile Leu 245 250 255 caa atg aat tca gcc aca gga aga cgc aag gca ttt tcc acg tgc tca 816 Gln Met Asn Ser Ala Thr Gly Arg Arg Lys Ala Phe Ser Thr Cys Ser 260 265 270 gct cac ctg act gtg gtg atc ata ttt tac ggt acc atc ttc ttt atg 864 Ala His Leu Thr Val Val Ile Ile Phe Tyr Gly Thr Ile Phe Phe Met 275 280 285 tat gcg aaa ccg aag tct caa gac ctg att ggg gaa gaa aaa ttg caa 912 Tyr Ala Lys Pro Lys Ser Gln Asp Leu Ile Gly Glu Glu Lys Leu Gln 290 295 300 gca tta gac aag ctc att tct ctg ttt tat ggg gta gtg aca ccc atg 960 Ala Leu Asp Lys Leu Ile Ser Leu Phe Tyr Gly Val Val Thr Pro Met 305 310 315 320 ctg aat cct ata ctc tat agc ttg aga aat aag gat gta aaa gct gct 1008 Leu Asn Pro Ile Leu Tyr Ser Leu Arg Asn Lys Asp Val Lys Ala Ala 325 330 335 gta aaa tat ttg ctg aac aaa aaa cca att cac taa 1044 Val Lys Tyr Leu Leu Asn Lys Lys Pro Ile His 340 345 <210> 536 <211> 347 <212> PRT <213> Homo sapiens <400> 536 Met Ile Val Gln Leu Ile Cys Thr Val Cys Phe Leu Ala Val Asn Thr 1 5 10 15 Phe His Val Arg Ser Ser Phe Asp Phe Leu Lys Ala Asp Asp Met Gly 20 25 30 Glu Ile Asn Gln Thr Leu Val Ser Glu Phe Leu Leu Leu Gly Leu Ser 35 40 45 Gly Tyr Pro Lys Ile Glu Ile Val Tyr Phe Ala Leu Ile Leu Val Met 50 55 60 Tyr Leu Val Ile Leu Ile Gly Asn Gly Val Leu Ile Ile Ala Ser Ile 65 70 75 80 Phe Asp Ser His Phe His Thr Pro Met Tyr Phe Phe Leu Gly Asn Leu 85 90 95 Ser Phe Leu Asp Ile Cys Tyr Thr Ser Ser Ser Val Pro Ser Thr Leu 100 105 110 Val Ser Leu Ile Ser Lys Lys Arg Asn Ile Ser Phe Ser Gly Cys Ala 115 120 125 Val Gln Met Phe Phe Gly Phe Ala Met Gly Ser Thr Glu Cys Leu Leu 130 135 140 Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn Pro Leu 145 150 155 160 Arg Tyr Pro Ile Ile Leu Ser Lys Val Ala Tyr Val Leu Met Ala Ser 165 170 175 Val Ser Trp Leu Ser Gly Gly Ile Asn Ser Ala Val Gln Thr Leu Leu 180 185 190 Ala Met Arg Leu Pro Phe Cys Gly Asn Asn Ile Ile Asn His Phe Ala 195 200 205 Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Ala Asp Ile Ser Leu 210 215 220 Asn Ile Ile Thr Met Val Ile Ser Asn Met Ala Phe Leu Val Leu Pro 225 230 235 240 Leu Met Val Ile Phe Phe Ser Tyr Met Phe Ile Leu Tyr Thr Ile Leu 245 250 255 Gln Met Asn Ser Ala Thr Gly Arg Arg Lys Ala Phe Ser Thr Cys Ser 260 265 270 Ala His Leu Thr Val Val Ile Ile Phe Tyr Gly Thr Ile Phe Phe Met 275 280 285 Tyr Ala Lys Pro Lys Ser Gln Asp Leu Ile Gly Glu Glu Lys Leu Gln 290 295 300 Ala Leu Asp Lys Leu Ile Ser Leu Phe Tyr Gly Val Val Thr Pro Met 305 310 315 320 Leu Asn Pro Ile Leu Tyr Ser Leu Arg Asn Lys Asp Val Lys Ala Ala 325 330 335 Val Lys Tyr Leu Leu Asn Lys Lys Pro Ile His 340 345 <210> 537 <211> 861 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(861) <400> 537 atg tac ctg atc acc ttg ctg ggc aac att ttt ctg atc tcc atc acc 48 Met Tyr Leu Ile Thr Leu Leu Gly Asn Ile Phe Leu Ile Ser Ile Thr 1 5 10 15 att cta gat tcc cac ctg cac acc cct atg tac ctc ttc ctc agc aat 96 Ile Leu Asp Ser His Leu His Thr Pro Met Tyr Leu Phe Leu Ser Asn 20 25 30 ctc tcc ttt ctg gac atc tgg tac tcc tct tct gcc ctc tct cca atg 144 Leu Ser Phe Leu Asp Ile Trp Tyr Ser Ser Ser Ala Leu Ser Pro Met 35 40 45 ctg gca aac ttt gtt tca ggg aga aac act att tca ttc tca ggg tgc 192 Leu Ala Asn Phe Val Ser Gly Arg Asn Thr Ile Ser Phe Ser Gly Cys 50 55 60 gcc act cag atg tac ctc tcc ctt gcc atg ggc tcc act gag tgt gtg 240 Ala Thr Gln Met Tyr Leu Ser Leu Ala Met Gly Ser Thr Glu Cys Val 65 70 75 80 ctc ctg ccc atg atg gca tat gac cgg tat gtg gcc atc tgc aac ccc 288 Leu Leu Pro Met Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn Pro 85 90 95 ctg aga tac cct gtc atc atg aat agg aga acc tgt gtg cag att gca 336 Leu Arg Tyr Pro Val Ile Met Asn Arg Arg Thr Cys Val Gln Ile Ala 100 105 110 gct ggc tcc tgg atg aca ggc tgt ctc act gcc atg gtg gaa atg atg 384 Ala Gly Ser Trp Met Thr Gly Cys Leu Thr Ala Met Val Glu Met Met 115 120 125 tct gtg ctg cca ctg tct ctc tgt ggt aat agc atc atc aat cat ttc 432 Ser Val Leu Pro Leu Ser Leu Cys Gly Asn Ser Ile Ile Asn His Phe 130 135 140 act tgt gaa att ctg gcc atc ttg aaa ttg gtt tgt gtg gac acc tcc 480 Thr Cys Glu Ile Leu Ala Ile Leu Lys Leu Val Cys Val Asp Thr Ser 145 150 155 160 ctg gtg cag tta atc atg ctg gtg atc agt gta ctt ctt ctc ccc atg 528 Leu Val Gln Leu Ile Met Leu Val Ile Ser Val Leu Leu Leu Pro Met 165 170 175 cca atg cta ctc att tgt atc tct tat gca ttt atc ctc gcc agt atc 576 Pro Met Leu Leu Ile Cys Ile Ser Tyr Ala Phe Ile Leu Ala Ser Ile 180 185 190 ctg aga atc agc tca gtg gaa ggt cga agt aaa gcc ttt tca acg tgc 624 Leu Arg Ile Ser Ser Val Glu Gly Arg Ser Lys Ala Phe Ser Thr Cys 195 200 205 aca gcc cac ctg atg gtg gta gtt ttg ttc tat ggg acg gct ctc tcc 672 Thr Ala His Leu Met Val Val Val Leu Phe Tyr Gly Thr Ala Leu Ser 210 215 220 atg cac ctg aag ccc tcc gct gta gat tca cag gaa ata gac aaa ttt 720 Met His Leu Lys Pro Ser Ala Val Asp Ser Gln Glu Ile Asp Lys Phe 225 230 235 240 atg gct ttg gtg tat gcc gga caa acc ccc atg ttg aat cct atc atc 768 Met Ala Leu Val Tyr Ala Gly Gln Thr Pro Met Leu Asn Pro Ile Ile 245 250 255 tat agt cta cgg aac aaa gag gtg aaa gtg gcc ttg aaa aaa ttg ctg 816 Tyr Ser Leu Arg Asn Lys Glu Val Lys Val Ala Leu Lys Lys Leu Leu 260 265 270 att aga aat cat ttt aat act gcc ttc att tcc atc ctc aaa taa 861 Ile Arg Asn His Phe Asn Thr Ala Phe Ile Ser Ile Leu Lys 275 280 285 <210> 538 <211> 286 <212> PRT <213> Homo sapiens <400> 538 Met Tyr Leu Ile Thr Leu Leu Gly Asn Ile Phe Leu Ile Ser Ile Thr 1 5 10 15 Ile Leu Asp Ser His Leu His Thr Pro Met Tyr Leu Phe Leu Ser Asn 20 25 30 Leu Ser Phe Leu Asp Ile Trp Tyr Ser Ser Ser Ala Leu Ser Pro Met 35 40 45 Leu Ala Asn Phe Val Ser Gly Arg Asn Thr Ile Ser Phe Ser Gly Cys 50 55 60 Ala Thr Gln Met Tyr Leu Ser Leu Ala Met Gly Ser Thr Glu Cys Val 65 70 75 80 Leu Leu Pro Met Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn Pro 85 90 95 Leu Arg Tyr Pro Val Ile Met Asn Arg Arg Thr Cys Val Gln Ile Ala 100 105 110 Ala Gly Ser Trp Met Thr Gly Cys Leu Thr Ala Met Val Glu Met Met 115 120 125 Ser Val Leu Pro Leu Ser Leu Cys Gly Asn Ser Ile Ile Asn His Phe 130 135 140 Thr Cys Glu Ile Leu Ala Ile Leu Lys Leu Val Cys Val Asp Thr Ser 145 150 155 160 Leu Val Gln Leu Ile Met Leu Val Ile Ser Val Leu Leu Leu Pro Met 165 170 175 Pro Met Leu Leu Ile Cys Ile Ser Tyr Ala Phe Ile Leu Ala Ser Ile 180 185 190 Leu Arg Ile Ser Ser Val Glu Gly Arg Ser Lys Ala Phe Ser Thr Cys 195 200 205 Thr Ala His Leu Met Val Val Val Leu Phe Tyr Gly Thr Ala Leu Ser 210 215 220 Met His Leu Lys Pro Ser Ala Val Asp Ser Gln Glu Ile Asp Lys Phe 225 230 235 240 Met Ala Leu Val Tyr Ala Gly Gln Thr Pro Met Leu Asn Pro Ile Ile 245 250 255 Tyr Ser Leu Arg Asn Lys Glu Val Lys Val Ala Leu Lys Lys Leu Leu 260 265 270 Ile Arg Asn His Phe Asn Thr Ala Phe Ile Ser Ile Leu Lys 275 280 285 <210> 539 <211> 963 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(963) <400> 539 atg gaa agg acc aac gat tcc acg tcg aca gaa ttt ttc ctg gta ggg 48 Met Glu Arg Thr Asn Asp Ser Thr Ser Thr Glu Phe Phe Leu Val Gly 1 5 10 15 ctt tct gcc cac cca aag ctc cag aca gtt ttc ttc gtt cta att ttg 96 Leu Ser Ala His Pro Lys Leu Gln Thr Val Phe Phe Val Leu Ile Leu 20 25 30 tgg atg tac ctg atg atc ctg ctt gga aat gga gtc ctt atc tca gtt 144 Trp Met Tyr Leu Met Ile Leu Leu Gly Asn Gly Val Leu Ile Ser Val 35 40 45 atc atc ttt gat tct cac ctg cac acc ccc atg tat ttc ttc ctc tgt 192 Ile Ile Phe Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Cys 50 55 60 aat ctt tcc ttc ctc gac gtt tgc tac aca agt tcc tct gtc cca cta 240 Asn Leu Ser Phe Leu Asp Val Cys Tyr Thr Ser Ser Ser Val Pro Leu 65 70 75 80 att ctt gcc agc ttt ctg gca gta aag aaa aag gtt tcc ttc tct ggg 288 Ile Leu Ala Ser Phe Leu Ala Val Lys Lys Lys Val Ser Phe Ser Gly 85 90 95 tgt atg gtg caa atg ttt att tct ttt gcc atg ggg gcc acg gag tgc 336 Cys Met Val Gln Met Phe Ile Ser Phe Ala Met Gly Ala Thr Glu Cys 100 105 110 atg atc tta ggc acg atg gca ctg gac cgc tat gtg gcc atc tgc tac 384 Met Ile Leu Gly Thr Met Ala Leu Asp Arg Tyr Val Ala Ile Cys Tyr 115 120 125 cca ctg aga tac cct gtc atc atg agc aag ggt gcc tat gtg gcc atg 432 Pro Leu Arg Tyr Pro Val Ile Met Ser Lys Gly Ala Tyr Val Ala Met 130 135 140 gca gct ggg tcc tgg gtc act ggg ctt gtg gac tca gta gtg cag aca 480 Ala Ala Gly Ser Trp Val Thr Gly Leu Val Asp Ser Val Val Gln Thr 145 150 155 160 gct ttt gca atg cag tta cca ttc tgt gct aat aat gtc att aaa cat 528 Ala Phe Ala Met Gln Leu Pro Phe Cys Ala Asn Asn Val Ile Lys His 165 170 175 ttt gtc tgt gaa att ctg gct atc ttg aaa ctg gcc tgt gct gat att 576 Phe Val Cys Glu Ile Leu Ala Ile Leu Lys Leu Ala Cys Ala Asp Ile 180 185 190 tca atc aat gtg att agt atg aca ggg tcg aat ctg att gtt ctg gtt 624 Ser Ile Asn Val Ile Ser Met Thr Gly Ser Asn Leu Ile Val Leu Val 195 200 205 att cca ttg tta gta att tcc atc tct tac ata ttt att gtt gcc act 672 Ile Pro Leu Leu Val Ile Ser Ile Ser Tyr Ile Phe Ile Val Ala Thr 210 215 220 att ctg agg att cct tcc act gaa gga aaa cat aag gcc ttc tcc acc 720 Ile Leu Arg Ile Pro Ser Thr Glu Gly Lys His Lys Ala Phe Ser Thr 225 230 235 240 tgc tca gcc cac ctg aca gtg gtg att ata ttc tat gga acc atc ttc 768 Cys Ser Ala His Leu Thr Val Val Ile Ile Phe Tyr Gly Thr Ile Phe 245 250 255 ttc atg tac gca aag cct gag tct aaa gcc tct gtt gat tca ggt aat 816 Phe Met Tyr Ala Lys Pro Glu Ser Lys Ala Ser Val Asp Ser Gly Asn 260 265 270 gaa gac atc att gag gcc ctc atc tcc ctt ttc tat gga gtg atg act 864 Glu Asp Ile Ile Glu Ala Leu Ile Ser Leu Phe Tyr Gly Val Met Thr 275 280 285 ccc atg ctt aat cct ctc atc tat agt ctg cga aac aag gat gta aag 912 Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys 290 295 300 gct gct gtc aaa aac ata ctg tgt agg aaa aac ttt tct gat gga aaa 960 Ala Ala Val Lys Asn Ile Leu Cys Arg Lys Asn Phe Ser Asp Gly Lys 305 310 315 320 tga 963 <210> 540 <211> 320 <212> PRT <213> Homo sapiens <400> 540 Met Glu Arg Thr Asn Asp Ser Thr Ser Thr Glu Phe Phe Leu Val Gly 1 5 10 15 Leu Ser Ala His Pro Lys Leu Gln Thr Val Phe Phe Val Leu Ile Leu 20 25 30 Trp Met Tyr Leu Met Ile Leu Leu Gly Asn Gly Val Leu Ile Ser Val 35 40 45 Ile Ile Phe Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Cys 50 55 60 Asn Leu Ser Phe Leu Asp Val Cys Tyr Thr Ser Ser Ser Val Pro Leu 65 70 75 80 Ile Leu Ala Ser Phe Leu Ala Val Lys Lys Lys Val Ser Phe Ser Gly 85 90 95 Cys Met Val Gln Met Phe Ile Ser Phe Ala Met Gly Ala Thr Glu Cys 100 105 110 Met Ile Leu Gly Thr Met Ala Leu Asp Arg Tyr Val Ala Ile Cys Tyr 115 120 125 Pro Leu Arg Tyr Pro Val Ile Met Ser Lys Gly Ala Tyr Val Ala Met 130 135 140 Ala Ala Gly Ser Trp Val Thr Gly Leu Val Asp Ser Val Val Gln Thr 145 150 155 160 Ala Phe Ala Met Gln Leu Pro Phe Cys Ala Asn Asn Val Ile Lys His 165 170 175 Phe Val Cys Glu Ile Leu Ala Ile Leu Lys Leu Ala Cys Ala Asp Ile 180 185 190 Ser Ile Asn Val Ile Ser Met Thr Gly Ser Asn Leu Ile Val Leu Val 195 200 205 Ile Pro Leu Leu Val Ile Ser Ile Ser Tyr Ile Phe Ile Val Ala Thr 210 215 220 Ile Leu Arg Ile Pro Ser Thr Glu Gly Lys His Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ala His Leu Thr Val Val Ile Ile Phe Tyr Gly Thr Ile Phe 245 250 255 Phe Met Tyr Ala Lys Pro Glu Ser Lys Ala Ser Val Asp Ser Gly Asn 260 265 270 Glu Asp Ile Ile Glu Ala Leu Ile Ser Leu Phe Tyr Gly Val Met Thr 275 280 285 Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys 290 295 300 Ala Ala Val Lys Asn Ile Leu Cys Arg Lys Asn Phe Ser Asp Gly Lys 305 310 315 320 <210> 541 <211> 978 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(978) <400> 541 atg aag act ttg tgt tcc ttt ctt cag atc agc aga aat atg cat caa 48 Met Lys Thr Leu Cys Ser Phe Leu Gln Ile Ser Arg Asn Met His Gln 1 5 10 15 gaa aac caa acc acc atc act gaa ttc att ctc ctg gga ctc tcc aac 96 Glu Asn Gln Thr Thr Ile Thr Glu Phe Ile Leu Leu Gly Leu Ser Asn 20 25 30 cag gct gaa cat caa aac ctc ctc ttt gtg ctt ttc ctg agt atg tat 144 Gln Ala Glu His Gln Asn Leu Leu Phe Val Leu Phe Leu Ser Met Tyr 35 40 45 gtg gtc act gtg gtt ggg aac ggg ctc atc att gtg gct atc agc ttg 192 Val Val Thr Val Val Gly Asn Gly Leu Ile Ile Val Ala Ile Ser Leu 50 55 60 gat ata tac ctt cac acc ccc atg tat ctc ttc ctt gcc tac cta tcc 240 Asp Ile Tyr Leu His Thr Pro Met Tyr Leu Phe Leu Ala Tyr Leu Ser 65 70 75 80 ttt gct gat att tcc tcc att tcc aac tca gtc ccc aaa atg ctg gtg 288 Phe Ala Asp Ile Ser Ser Ile Ser Asn Ser Val Pro Lys Met Leu Val 85 90 95 aat att caa acc aac agc caa tcc atc tct tat gag agc tgc atc aca 336 Asn Ile Gln Thr Asn Ser Gln Ser Ile Ser Tyr Glu Ser Cys Ile Thr 100 105 110 cag atg tac ttt tct att gtg ttt gtc gtc act gac aat ttg ctt ttg 384 Gln Met Tyr Phe Ser Ile Val Phe Val Val Thr Asp Asn Leu Leu Leu 115 120 125 ggg acc atg gcc ttc gac cac ttt gtg gcg atc tgc cac cct ctg aac 432 Gly Thr Met Ala Phe Asp His Phe Val Ala Ile Cys His Pro Leu Asn 130 135 140 tat aca act ttc atg cgg gcc agg ttc ggc act ttg ctc aca gtc atc 480 Tyr Thr Thr Phe Met Arg Ala Arg Phe Gly Thr Leu Leu Thr Val Ile 145 150 155 160 tcg tgg ttc ctc agt aat att att gct ctt aca cac acc ctt ctg ctc 528 Ser Trp Phe Leu Ser Asn Ile Ile Ala Leu Thr His Thr Leu Leu Leu 165 170 175 att caa ttg ctc ttc tgt gac cac aac act ctc cca cac ttc ttc tgt 576 Ile Gln Leu Leu Phe Cys Asp His Asn Thr Leu Pro His Phe Phe Cys 180 185 190 gac ttg gcc cct ctg ctc aaa ctg tcc tgt tca gat aca atg atc aat 624 Asp Leu Ala Pro Leu Leu Lys Leu Ser Cys Ser Asp Thr Met Ile Asn 195 200 205 gag ctt gtg ttg ttt att gtg ggt tta tca gtt atc atc ttc ccc ttt 672 Glu Leu Val Leu Phe Ile Val Gly Leu Ser Val Ile Ile Phe Pro Phe 210 215 220 gta ctc atc ttc ttc tcc tat gtc tgc atc atc aga gct gtc ctg gga 720 Val Leu Ile Phe Phe Ser Tyr Val Cys Ile Ile Arg Ala Val Leu Gly 225 230 235 240 gta tca tcc aca cag gga aag tgg aaa gcc ttc tcc act tgt ggc tct 768 Val Ser Ser Thr Gln Gly Lys Trp Lys Ala Phe Ser Thr Cys Gly Ser 245 250 255 cac ctg aca att gca tta ctg ttc tac gga acc act gta ggc gtg tac 816 His Leu Thr Ile Ala Leu Leu Phe Tyr Gly Thr Thr Val Gly Val Tyr 260 265 270 ttt ttc ccc tcc tcc act cac cct gag gac act gat aag att ggt gct 864 Phe Phe Pro Ser Ser Thr His Pro Glu Asp Thr Asp Lys Ile Gly Ala 275 280 285 gtc cta ttc act gtg gtg aca ccc atg atg aac ccc ttc atc tac agc 912 Val Leu Phe Thr Val Val Thr Pro Met Met Asn Pro Phe Ile Tyr Ser 290 295 300 ttg agg aat aag gat atg aaa ggt gcc ctg aga aag ctc atc aat aga 960 Leu Arg Asn Lys Asp Met Lys Gly Ala Leu Arg Lys Leu Ile Asn Arg 305 310 315 320 aaa att tct tcc ctt tga 978 Lys Ile Ser Ser Leu 325 <210> 542 <211> 325 <212> PRT <213> Homo sapiens <400> 542 Met Lys Thr Leu Cys Ser Phe Leu Gln Ile Ser Arg Asn Met His Gln 1 5 10 15 Glu Asn Gln Thr Thr Ile Thr Glu Phe Ile Leu Leu Gly Leu Ser Asn 20 25 30 Gln Ala Glu His Gln Asn Leu Leu Phe Val Leu Phe Leu Ser Met Tyr 35 40 45 Val Val Thr Val Val Gly Asn Gly Leu Ile Ile Val Ala Ile Ser Leu 50 55 60 Asp Ile Tyr Leu His Thr Pro Met Tyr Leu Phe Leu Ala Tyr Leu Ser 65 70 75 80 Phe Ala Asp Ile Ser Ser Ile Ser Asn Ser Val Pro Lys Met Leu Val 85 90 95 Asn Ile Gln Thr Asn Ser Gln Ser Ile Ser Tyr Glu Ser Cys Ile Thr 100 105 110 Gln Met Tyr Phe Ser Ile Val Phe Val Val Thr Asp Asn Leu Leu Leu 115 120 125 Gly Thr Met Ala Phe Asp His Phe Val Ala Ile Cys His Pro Leu Asn 130 135 140 Tyr Thr Thr Phe Met Arg Ala Arg Phe Gly Thr Leu Leu Thr Val Ile 145 150 155 160 Ser Trp Phe Leu Ser Asn Ile Ile Ala Leu Thr His Thr Leu Leu Leu 165 170 175 Ile Gln Leu Leu Phe Cys Asp His Asn Thr Leu Pro His Phe Phe Cys 180 185 190 Asp Leu Ala Pro Leu Leu Lys Leu Ser Cys Ser Asp Thr Met Ile Asn 195 200 205 Glu Leu Val Leu Phe Ile Val Gly Leu Ser Val Ile Ile Phe Pro Phe 210 215 220 Val Leu Ile Phe Phe Ser Tyr Val Cys Ile Ile Arg Ala Val Leu Gly 225 230 235 240 Val Ser Ser Thr Gln Gly Lys Trp Lys Ala Phe Ser Thr Cys Gly Ser 245 250 255 His Leu Thr Ile Ala Leu Leu Phe Tyr Gly Thr Thr Val Gly Val Tyr 260 265 270 Phe Phe Pro Ser Ser Thr His Pro Glu Asp Thr Asp Lys Ile Gly Ala 275 280 285 Val Leu Phe Thr Val Val Thr Pro Met Met Asn Pro Phe Ile Tyr Ser 290 295 300 Leu Arg Asn Lys Asp Met Lys Gly Ala Leu Arg Lys Leu Ile Asn Arg 305 310 315 320 Lys Ile Ser Ser Leu 325 <210> 543 <211> 978 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(978) <400> 543 atg aag act ttt agt tcc ttt ctt cag atc ggc aga aat atg cat caa 48 Met Lys Thr Phe Ser Ser Phe Leu Gln Ile Gly Arg Asn Met His Gln 1 5 10 15 gga aac caa acc acc atc act gaa ttc att ctc ctg gga ttt ttc aag 96 Gly Asn Gln Thr Thr Ile Thr Glu Phe Ile Leu Leu Gly Phe Phe Lys 20 25 30 cag gat gag cat caa aac ctc ctc ttt gtg ctt ttc ttg ggt atg tac 144 Gln Asp Glu His Gln Asn Leu Leu Phe Val Leu Phe Leu Gly Met Tyr 35 40 45 ctg gtc act gtg att ggg aac ggg ctc atc att gtg gct atc agc ttg 192 Leu Val Thr Val Ile Gly Asn Gly Leu Ile Ile Val Ala Ile Ser Leu 50 55 60 gat acg tac ctt cat acc ccc atg tat ctc ttc ctt gcc aat cta tcc 240 Asp Thr Tyr Leu His Thr Pro Met Tyr Leu Phe Leu Ala Asn Leu Ser 65 70 75 80 ttt gct gat att tcc tcc att tcc aac tca gtc ccc aaa atg ctg gtg 288 Phe Ala Asp Ile Ser Ser Ile Ser Asn Ser Val Pro Lys Met Leu Val 85 90 95 aat att caa acc aag agt caa tcc atc tct tat gag agc tgc atc aca 336 Asn Ile Gln Thr Lys Ser Gln Ser Ile Ser Tyr Glu Ser Cys Ile Thr 100 105 110 cag atg tac ttt tct att gtg ttt gtc gtc att gac aat ttg ctc ttg 384 Gln Met Tyr Phe Ser Ile Val Phe Val Val Ile Asp Asn Leu Leu Leu 115 120 125 ggg acc atg gcc tat gac cac ttt gtg gcg atc tgc cac cct ctg aat 432 Gly Thr Met Ala Tyr Asp His Phe Val Ala Ile Cys His Pro Leu Asn 130 135 140 tat aca att ctc atg cgg ccc agg ttc ggc att ttg ctc aca gtc atc 480 Tyr Thr Ile Leu Met Arg Pro Arg Phe Gly Ile Leu Leu Thr Val Ile 145 150 155 160 tca tgg ttc ctc agt aat att att gct ctg aca cac acc ctt ctg ctc 528 Ser Trp Phe Leu Ser Asn Ile Ile Ala Leu Thr His Thr Leu Leu Leu 165 170 175 att caa ttg ctc ttc tgt aac cac aac act ctc cca cac ttc ttc tgt 576 Ile Gln Leu Leu Phe Cys Asn His Asn Thr Leu Pro His Phe Phe Cys 180 185 190 gac ttg gcc cct ctg ctc aaa ctg tcc tgt tca gat aca ttg atc aat 624 Asp Leu Ala Pro Leu Leu Lys Leu Ser Cys Ser Asp Thr Leu Ile Asn 195 200 205 gag ctt gtg ttg ttt att gtg ggt tta tca gtt atc atc ttc ccc ttt 672 Glu Leu Val Leu Phe Ile Val Gly Leu Ser Val Ile Ile Phe Pro Phe 210 215 220 aca ctc agc ttc ttt tcc tat gtc tgc atc atc aga gct gtc ctg aga 720 Thr Leu Ser Phe Phe Ser Tyr Val Cys Ile Ile Arg Ala Val Leu Arg 225 230 235 240 gta tct tcc aca cag gga aag tgg aaa gcc ttc tcc act tgt ggc tct 768 Val Ser Ser Thr Gln Gly Lys Trp Lys Ala Phe Ser Thr Cys Gly Ser 245 250 255 cac ctg aca gtt gta tta ctg ttc tac gga acc att gta ggc gtg tac 816 His Leu Thr Val Val Leu Leu Phe Tyr Gly Thr Ile Val Gly Val Tyr 260 265 270 ttt ttc ccc tcc tcc act cac cct gag gac act gat aag att ggt gct 864 Phe Phe Pro Ser Ser Thr His Pro Glu Asp Thr Asp Lys Ile Gly Ala 275 280 285 gtc cta ttc act gtg gtg aca ccc atg ata aac ccc ttc atc tac agc 912 Val Leu Phe Thr Val Val Thr Pro Met Ile Asn Pro Phe Ile Tyr Ser 290 295 300 ttg agg aat aag gat atg aaa ggt gcc ctg aga aag ctc atc aat aga 960 Leu Arg Asn Lys Asp Met Lys Gly Ala Leu Arg Lys Leu Ile Asn Arg 305 310 315 320 aaa att tct tcc ctt tga 978 Lys Ile Ser Ser Leu 325 <210> 544 <211> 325 <212> PRT <213> Homo sapiens <400> 544 Met Lys Thr Phe Ser Ser Phe Leu Gln Ile Gly Arg Asn Met His Gln 1 5 10 15 Gly Asn Gln Thr Thr Ile Thr Glu Phe Ile Leu Leu Gly Phe Phe Lys 20 25 30 Gln Asp Glu His Gln Asn Leu Leu Phe Val Leu Phe Leu Gly Met Tyr 35 40 45 Leu Val Thr Val Ile Gly Asn Gly Leu Ile Ile Val Ala Ile Ser Leu 50 55 60 Asp Thr Tyr Leu His Thr Pro Met Tyr Leu Phe Leu Ala Asn Leu Ser 65 70 75 80 Phe Ala Asp Ile Ser Ser Ile Ser Asn Ser Val Pro Lys Met Leu Val 85 90 95 Asn Ile Gln Thr Lys Ser Gln Ser Ile Ser Tyr Glu Ser Cys Ile Thr 100 105 110 Gln Met Tyr Phe Ser Ile Val Phe Val Val Ile Asp Asn Leu Leu Leu 115 120 125 Gly Thr Met Ala Tyr Asp His Phe Val Ala Ile Cys His Pro Leu Asn 130 135 140 T yr Thr Ile Leu Met Arg Pro Arg Phe Gly Ile Leu Leu Thr Val Ile 145 150 155 160 Ser Trp Phe Leu Ser Asn Ile Ile Ala Leu Thr His Thr Leu Leu Leu 165 170 175 Ile Gln Leu Leu Phe Cys Asn His Asn Thr Leu Pro His Phe Phe Cys 180 185 190 Asp Leu Ala Pro Leu Leu Lys Leu Ser Cys Ser Asp Thr Leu Ile Asn 195 200 205 Glu Leu Val Leu Phe Ile Val Gly Leu Ser Val Ile Ile Phe Pro Phe 210 215 220 Thr Leu Ser Phe Phe Ser Tyr Val Cys Ile Ile Arg Ala Val Leu Arg 225 230 235 240 Val Ser Ser Thr Gln Gly Lys Trp Lys Ala Phe Ser Thr Cys Gly Ser 245 250 255 His Leu Thr Val Val Leu Leu Phe Tyr Gly Thr Ile Val Gly Val Tyr 260 265 270 Phe Phe Pro Ser Ser Thr His Pro Glu Asp Thr Asp Lys Ile Gly Ala 275 280 285 Val Leu Phe Thr Val Val Thr Pro Met Ile Asn Pro Phe Ile Tyr Ser 290 295 300 Leu Arg Asn Lys Asp Met Lys Gly Ala Leu Arg Lys Leu Ile Asn Arg 305 310 315 320 Lys Ile Ser Ser Leu 325 <210> 545 <211> 960 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(960) <400> 545 atg cct gtg ggg aaa ctt gtc ttc aac cag tct gag ccc act gag ttt 48 M et Pro Val Gly Lys Leu Val Phe Asn Gln Ser Glu Pro Thr Glu Phe 1 5 10 15 gtg ttc cgt gcg ttc acc aca gcc act gaa ttc cag gtt ctt ctc ttc 96 Val Phe Arg Ala Phe Thr Thr Ala Thr Glu Phe Gln Val Leu Leu Phe 20 25 30 ctt ctc ttc ctc ctc ctc tac ttg atg atc ctc tgt ggc aac aca gcc 144 Leu Leu Phe Leu Leu Leu Tyr Leu Met Ile Leu Cys Gly Asn Thr Ala 35 40 45 atc atc tgg gtg gtg tgc aca cac agc acc ctc cgc acc ccg atg tat 192 Ile Ile Trp Val Val Cys Thr His Ser Thr Leu Arg Thr Pro Met Tyr 50 55 60 ttc ttc ctg tcc aac ctg tct ttc ctg gaa ctc tgc tac acc acc gtg 240 Phe Phe Leu Ser Asn Leu Ser Phe Leu Glu Leu Cys Tyr Thr Thr Val 65 70 75 80 gta gta ccc ttg atg ctt tcc aac att ttg ggg gcc cag aag ccc att 288 Val Val Pro Leu Met Leu Ser Asn Ile Leu Gly Ala Gln Lys Pro Ile 85 90 95 tcg ttg gct gga tgt ggg gcc caa atg ttc ttc ttt gtc acc ctc ggc 336 Ser Leu Ala Gly Cys Gly Ala Gln Met Phe Phe Phe Val Thr Leu Gly 100 105 110 agc acg gac tgt ttc ctc ttg gcg atc atg gcc tat gac cgc tat gtg 384 Ser Thr Asp Cys Phe Leu Leu Ala Ile Met Ala Tyr Asp Arg Tyr Val 115 120 125 gct atc tgc cac ccg ctg cac tac acc ctc atc atg acc cgc gag ctg 432 Ala Ile Cys His Pro Leu His Tyr Thr Leu Ile Met Thr Arg Glu Leu 130 135 140 tgc acg cag atg ctg ggt ggg gcc ctg ggc ctg gcc ctc ttc ccc tcc 480 Cys Thr Gln Met Leu Gly Gly Ala Leu Gly Leu Ala Leu Phe Pro Ser 145 150 155 160 ctg cag ctc acc gcc tta atc ttc acc ctg ccc ttt tgc ggc cac cac 528 Leu Gln Leu Thr Ala Leu Ile Phe Thr Leu Pro Phe Cys Gly His His 165 170 175 cag gaa atc aac cac ttc ctc tgc gat gtg cct ccc gtc ctg cgc ctg 576 Gln Glu Ile Asn His Phe Leu Cys Asp Val Pro Pro Val Leu Arg Leu 180 185 190 gcc tgc gct gac atc cgc gtg cac cag gct gtc ctc tat gtc gtg agc 624 Ala Cys Ala Asp Ile Arg Val His Gln Ala Val Leu Tyr Val Val Ser 195 200 205 atc ctc gtg ctg acc atc ccc ttc ctg ctc atc tgc gtc tcc tac gtg 672 Ile Leu Val Leu Thr Ile Pro Phe Leu Leu Ile Cys Val Ser Tyr Val 210 215 220 ttc atc acc tgt gcc atc ctg agc atc cgt tct gcc gag ggc cgc cgc 720 Phe Ile Thr Cys Ala Ile Leu Ser Ile Arg Ser Ala Glu Gly Arg Arg 225 230 235 240 cgg gcc ttc tcc acc tgc tcc ttc cac ctc acc gtg gtc ctg ctg cag 768 Arg Ala Phe Ser Thr Cys Ser Phe His Leu Thr Val Val Leu Leu Gln 245 250 255 tat ggc tgc tgc agc ctc gtg tac ctg cgt cct cgg tcc agc acc tca 816 Tyr Gly Cys Cys Ser Leu Val Tyr Leu Arg Pro Arg Ser Ser Thr Ser 260 265 270 gag gat gag gac agc caa atc gcg ttg gtc tac acc ttt gtc acc ccc 864 Glu Asp Glu Asp Ser Gln Ile Ala Leu Val Tyr Thr Phe Val Thr Pro 275 280 285 tta ctc aac cct ttg ctt tac agc ctt agg aac aag gat gtc aaa ggt 912 Leu Leu Asn Pro Leu Leu Tyr Ser Leu Arg Asn Lys Asp Val Lys Gly 290 295 300 gct ctg agg agt gcc att atc cgt aaa gca gcc tct gac gcc aac tga 960 Ala Leu Arg Ser Ala Ile Ile Arg Lys Ala Ala Ser Asp Ala Asn 305 310 315 320 <210> 546 <211> 319 <212> PRT <213> Homo sapiens <400> 546 Met Pro Val Gly Lys Leu Val Phe Asn Gln Ser Glu Pro Thr Glu Phe 1 5 10 15 Val Phe Arg Ala Phe Thr Thr Ala Thr Glu Phe Gln Val Leu Leu Phe 20 25 30 Leu Leu Phe Leu Leu Leu Tyr Leu Met Ile Leu Cys Gly Asn Thr Ala 35 40 45 Ile Ile Trp Val Val Cys Thr His Ser Thr Leu Arg Thr Pro Met Tyr 50 55 60 Phe Phe Leu Ser Asn Leu Ser Phe Leu Glu Leu Cys Tyr Thr Thr Val 65 70 75 80 Val Val Pro Leu Met Leu Ser Asn Ile Leu Gly Ala Gln Lys Pro Ile 85 90 95 Ser Leu Ala Gly Cys Gly Ala Gln Met Phe Phe Phe Val Thr Leu Gly 100 105 110 Ser Thr Asp Cys Phe Leu Leu Ala Ile Met Ala Tyr Asp Arg Tyr Val 115 120 125 Ala Ile Cys His Pro Leu His Tyr Thr Leu Ile Met Thr Arg Glu Leu 130 135 140 Cys Thr Gln Met Leu Gly Gly Ala Leu Gly Leu Ala Leu Phe Pro Ser 145 150 155 160 Leu Gln Leu Thr Ala Leu Ile Phe Thr Leu Pro Phe Cys Gly His His 165 170 175 Gln Glu Ile Asn His Phe Leu Cys Asp Val Pro Pro Val Leu Arg Leu 180 185 190 Ala Cys Ala Asp Ile Arg Val His Gln Ala Val Leu Tyr Val Val Ser 195 200 205 Ile Leu Val Leu Thr Ile Pro Phe Leu Leu Ile Cys Val Ser Tyr Val 210 215 220 Phe Ile Thr Cys Ala Ile Leu Ser Ile Arg Ser Ala Glu Gly Arg Arg 225 230 235 240 Arg Ala Phe Ser Thr Cys Ser Phe His Leu Thr Val Val Leu Leu Gln 245 250 255 Tyr Gly Cys Cys Ser Leu Val Tyr Leu Arg Pro Arg Ser Ser Thr Ser 260 265 270 Glu Asp Glu Asp Ser Gln Ile Ala Leu Val Tyr Thr Phe Val Thr Pro 275 280 285 Leu Leu Asn Pro Leu Leu Tyr Ser Leu Arg Asn Lys Asp Val Lys Gly 290 295 300 Ala Leu Arg Ser Ala Ile Ile Arg Lys Ala Ala Ser Asp Ala Asn 305 310 315 <210> 547 <211> 933 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(933) <400> 547 atg gca gag atg aac ctc acc ttg gtg acc gag ttc ctc ctt att gca 48 Met Ala Glu Met Asn Leu Thr Leu Val Thr Glu Phe Leu Leu Ile Ala 1 5 10 15 ttc act gaa tat cct gaa tgg gca ctc cct ctc ttc ctc ttg ttt tta 96 Phe Thr Glu Tyr Pro Glu Trp Ala Leu Pro Leu Phe Leu Leu Phe Leu 20 25 30 ttt atg tat ctc atc acc gta ttg ggg aac tta gag atg att att ctg 144 Phe Met Tyr Leu Ile Thr Val Leu Gly Asn Leu Glu Met Ile Ile Leu 35 40 45 atc ctc atg gat cac cag ctc cac gct cca atg tat ttc ctt ctg agt 192 Ile Leu Met Asp His Gln Leu His Ala Pro Met Tyr Phe Leu Leu Ser 50 55 60 cac ctc gct ttc atg gac gtc tgc tac tca tct atc act gtc ccc cag 240 His Leu Ala Phe Met Asp Val Cys Tyr Ser Ser Ile Thr Val Pro Gln 65 70 75 80 atg ctg gca gtg ctg ctg gag cat ggg gca gct tta tct tac aca cgc 288 Met Leu Ala Val Leu Leu Glu His Gly Ala Ala Leu Ser Tyr Thr Arg 85 90 95 tgt gct gct cag ttc ttt ctg ttc acc ttc ttt ggt tcc atc gac tgc 336 Cys Ala Ala Gln Phe Phe Leu Phe Thr Phe Phe Gly Ser Ile Asp Cys 100 105 110 tac ctc ttg gcc ctc atg gcc tat gac cgc tac ttg gct gtg tgc cag 384 Tyr Leu Leu Ala Leu Met Ala Tyr Asp Arg Tyr Leu Ala Val Cys Gln 115 120 125 ccc ctg ctt tat gtc acc atc ctg aca cag cag gcc cgc ttg agt ctt 432 Pro Leu Leu Tyr Val Thr Ile Leu Thr Gln Gln Ala Arg Leu Ser Leu 130 135 140 gtg gct ggg gct tac gtt gct ggt ctc atc agt gcc ttg gtg cgg aca 480 Val Ala Gly Ala Tyr Val Ala Gly Leu Ile Ser Ala Leu Val Arg Thr 145 150 155 160 gtc tca gcc ttc act ctc tcc ttc tgt gga acc agt gag att gac ttt 528 Val Ser Ala Phe Thr Leu Ser Phe Cys Gly Thr Ser Glu Ile Asp Phe 165 170 175 at t ttc tgt gac ctc cct cct ctg tta aag ttg acc tgt ggg gag agc 576 Ile Phe Cys Asp Leu Pro Pro Leu Leu Lys Leu Thr Cys Gly Glu Ser 180 185 190 tac act caa gaa gtg ctg att att atg ttt gcc att ttt gtc atc cct 624 Tyr Thr Gln Glu Val Leu Ile Ile Met Phe Ala Ile Phe Val Ile Pro 195 200 205 gct tcc atg gtg gtg atc ttg gtg tcc tac ctg ttt atc atc gtg gcc 672 Ala Ser Met Val Val Ile Leu Val Ser Tyr Leu Phe Ile Ile Val Ala 210 215 220 atc atg ggg atc cct gct gga agc cag gcc aag acc ttc tcc acc tgc 720 Ile Met Gly Ile Pro Ala Gly Ser Gln Ala Lys Thr Phe Ser Thr Cys 225 230 235 240 acc tcc cac ctc act gct gtg tca ctc ttc ttt ggt acc ctc atc ttc 768 Thr Ser His Leu Thr Ala Val Ser Leu Phe Phe Gly Thr Leu Ile Phe 245 250 255 atg tac ttg aga ggt aac tca gat cag tct tcg gag aag aat cgg gta 816 Met Tyr Leu Arg Gly Asn Ser Asp Gln Ser Ser Glu Lys Asn Arg Val 260 265 270 gtg tct gtg ctt tac aca gag gtc atc ccc atg ttg aat ccc ctc atc 864 Val Ser Val Leu Tyr Thr Glu Val Ile Pro Met Leu Asn Pro Leu Ile 275 280 285 tac agc ctg agg aac aag gaa gtg aag gag gcc ctg aga aaa att ctc 912 Tyr Ser Leu Arg Asn Lys Glu Val Lys Glu Ala Leu Arg Lys Ile Leu 290 295 300 aat aga gcc aag ttg tcc taa 933 Asn Arg Ala Lys Leu Ser 305 310 <210> 548 <211> 310 <212> PRT <213> Homo sapiens <400> 548 Met Ala Glu Met Asn Leu Thr Leu Val Thr Glu Phe Leu Leu Ile Ala 1 5 10 15 Phe Thr Glu Tyr Pro Glu Trp Ala Leu Pro Leu Phe Leu Leu Phe Leu 20 25 30 Phe Met Tyr Leu Ile Thr Val Leu Gly Asn Leu Glu Met Ile Ile Leu 35 40 45 Ile Leu Met Asp His Gln Leu His Ala Pro Met Tyr Phe Leu Leu Ser 50 55 60 His Leu Ala Phe Met Asp Val Cys Tyr Ser Ser Ile Thr Val Pro Gln 65 70 75 80 Met Leu Ala Val Leu Leu Glu His Gly Ala Ala Leu Ser Tyr Thr Arg 85 90 95 Cys Ala Ala Gln Phe Phe Leu Phe Thr Phe Phe Gly Ser Ile Asp Cys 100 105 110 Tyr Leu Leu Ala Leu Met Ala Tyr Asp Arg Tyr Leu Ala Val Cys Gln 115 120 125 Pro Leu Leu Tyr Val Thr Ile Leu Thr Gln Gln Ala Arg Leu Ser Leu 130 135 140 Val Ala Gly Ala Tyr Val Ala Gly Leu Ile Ser Ala Leu Val Arg Thr 145 150 155 160 Val Ser Ala Phe Thr Leu Ser Phe Cys Gly Thr Ser Glu Ile Asp Phe 165 170 175 Ile Phe Cys Asp Leu Pro Pro Leu Leu Lys Leu Thr Cys Gly Glu Ser 180 185 190 Tyr Thr Gln Glu Val Leu Ile Ile Met Phe Ala Ile Phe Val Ile Pro 195 200 205 Ala Ser Met Val Val Ile Leu Val Ser Tyr Leu Phe Ile Ile Val Ala 210 215 220 Ile Met Gly Ile Pro Ala Gly Ser Gln Ala Lys Thr Phe Ser Thr Cys 225 230 235 240 Thr Ser His Leu Thr Ala Val Ser Leu Phe Phe Gly Thr Leu Ile Phe 245 250 255 Met Tyr Leu Arg Gly Asn Ser Asp Gln Ser Ser Glu Lys Asn Arg Val 260 265 270 Val Ser Val Leu Tyr Thr Glu Val Ile Pro Met Leu Asn Pro Leu Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Glu Val Lys Glu Ala Leu Arg Lys Ile Leu 290 295 300 Asn Arg Ala Lys Leu Ser 305 310 <210> 549 <211> 927 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(927) <400> 549 atg gcc atg gac aat gtc aca gca gtg ttt cag ttt ctc ctt att ggc 48 Met Ala Met Asp Asn Val Thr Ala Val Phe Gln Phe Leu Leu Ile Gly 1 5 10 15 att tct aac tat cct caa tgg aga gac acg ttt ttc aca tta gtg ctg 96 Ile Ser Asn Tyr Pro Gln Trp Arg Asp Thr Phe Phe Thr Leu Val Leu 20 25 30 ata att tac ctc agc aca ttg ttg ggg aat gga ttt atg atc ttt ctt 144 Ile Ile Tyr Leu Ser Thr Leu Leu Gly Asn Gly Phe Met Ile Phe Leu 35 40 45 att cac ttt gac ccc aac ctc cac act cca atc tac ttc ttc ctt agt 192 Ile His Phe Asp Pro Asn Leu His Thr Pro Ile Tyr Phe Phe Leu Ser 50 55 60 aac ctg tct ttc tta gac ctt tgt tat gga aca gct tcc atg ccc cag 240 Asn Leu Ser Phe Leu Asp Leu Cys Tyr Gly Thr Ala Ser Met Pro Gln 65 70 75 80 gct ttg gtg cat tgt ttc tct acc cat ccc tac ctc tct tat ccc cga 288 Ala Leu Val His Cys Phe Ser Thr His Pro Tyr Leu Ser Tyr Pro Arg 85 90 95 tgt ttg gct caa acg agt gtc tcc ttg gct ttg gcc aca gca gag tgc 336 Cys Leu Ala Gln Thr Ser Val Ser Leu Ala Leu Ala Thr Ala Glu Cys 100 105 110 ctc cta ctg gct gcc atg gcc tat gac cgt gtg gtt gct atc agc aat 384 Leu Leu Leu Ala Ala Met Ala Tyr Asp Arg Val Val Ala Ile Ser Asn 115 120 125 ccc ctg cgt tat tca gtg gtt atg aat ggc cca gta tgt gtc tgc ttg 432 Pro Leu Arg Tyr Ser Val Val Met Asn Gly Pro Val Cys Val Cys Leu 130 135 140 gtt gct acc tca tgg ggg aca tca ctt gtg ctc act gcc atg ctc atc 480 Val Ala Thr Ser Trp Gly Thr Ser Leu Val Leu Thr Ala Met Leu Ile 145 150 155 160 cta tcc ctg agg ctt cac ttc tgt ggg gct aat gtc atc aac cat ttt 528 Leu Ser Leu Arg Leu His Phe Cys Gly Ala Asn Val Ile Asn His Phe 165 170 175 gcc tgt gag att ctc tcc ctc att aag ctg acc tgt tct gat acc agc 576 Ala Cys Glu Ile Leu Ser Leu Ile Lys Leu Thr Cys Ser Asp Thr Ser 180 185 190 ctc aat gaa ttt atg atc ctc atc acc agt atc ttc acc ctg ctg cta 624 Leu Asn Glu Phe Met Ile Leu Ile Thr Ser Ile Phe Thr Leu Leu Leu 195 200 205 cca ttt ggg ttt gtt ctc ctc tcc tac ata cga att gct atg gct atc 672 Pro Phe Gly Phe Val Leu Leu Ser Tyr Ile Arg Ile Ala Met Ala Ile 210 215 220 ata agg att cgc tca ctc cag ggc agg ctc aag gcc ttt acc aca tgt 720 Ile Arg Ile Arg Ser Leu Gln Gly Arg Leu Lys Ala Phe Thr Thr Cys 225 230 235 240 ggc tct cac ctg acc gtg gtg aca atc ttc tat ggg tca gcc atc tcc 768 Gly Ser His Leu Thr Val Val Thr Ile Phe Tyr Gly Ser Ala Ile Ser 245 250 255 atg tat atg aaa act cag tcc aag tcc tac cct gac cag gac aag ttt 816 Met Tyr Met Lys Thr Gln Ser Lys Ser Tyr Pro Asp Gln Asp Lys Phe 260 265 270 atc tca gtg ttt tat gga gct ttg aca ccc atg ttg aac ccc ctg ata 864 Ile Ser Val Phe Tyr Gly Ala Leu Thr Pro Met Leu Asn Pro Leu Ile 275 280 285 tat agc ctg aga aaa aaa gat gtt aaa cgg gca ata agg aaa gtt atg 912 Tyr Ser Leu Arg Lys Lys Asp Val Lys Arg Ala Ile Arg Lys Val Met 290 295 300 ttg aaa agg aca tga 927 Leu Lys Arg Thr 305 <210> 550 <211> 308 <212> PRT <213> Homo sapiens <400> 550 Met Ala Met Asp Asn Val Thr Ala Val Phe Gln Phe Leu Leu Ile Gly 1 5 10 15 Ile Ser Asn Tyr Pro Gln Trp Arg Asp Thr Phe Phe Thr Leu Val Leu 20 25 30 Ile Ile Tyr Leu Ser Thr Leu Leu Gly Asn Gly Phe Met Ile Phe Leu 35 40 45 Ile His Phe Asp Pro Asn Leu His Thr Pro Ile Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Leu Asp Leu Cys Tyr Gly Thr Ala Ser Met Pro Gln 65 70 75 80 Ala Leu Val His Cys Phe Ser Thr His Pro Tyr Leu Ser Tyr Pro Arg 85 90 95 Cys Leu Ala Gln Thr Ser Val Ser Leu Ala Leu Ala Thr Ala Glu Cys 100 105 110 Leu Leu Leu Ala Ala Met Ala Tyr Asp Arg Val Val Ala Ile Ser Asn 115 120 125 Pro Leu Arg Tyr Ser Val Val Met Asn Gly Pro Val Cys Val Cys Leu 130 135 140 Val Ala Thr Ser Trp Gly Thr Ser Leu Val Leu Thr Ala Met Leu Ile 145 150 155 160 Leu Ser Leu Arg Leu His Phe Cys Gly Ala Asn Val Ile Asn His Phe 165 170 175 Ala Cys Glu Ile Leu Ser Leu Ile Lys Leu Thr Cys Ser Asp Thr Ser 180 185 190 Leu Asn Glu Phe Met Ile Leu Ile Thr Ser Ile Phe Thr Leu Leu Leu 195 200 205 Pro Phe Gly Phe Val Leu Leu Ser Tyr Ile Arg Ile Ala Met Ala Ile 210 215 220 Ile Arg Ile Arg Ser Leu Gln Gly Arg Leu Lys Ala Phe Thr Thr Cys 225 230 235 240 Gly Ser His Leu Thr Val Val Thr Ile Phe Tyr Gly Ser Ala Ile Ser 245 250 255 Met Tyr Met Lys Thr Gln Ser Lys Ser Tyr Pro Asp Gln Asp Lys Phe 260 265 270 Ile Ser Val Phe Tyr Gly Ala Leu Thr Pro Met Leu Asn Pro Leu Ile 275 280 285 Tyr Ser Leu Arg Lys Lys Asp Val Lys Arg Ala Ile Arg Lys Val Met 290 295 300 Leu Lys Arg Thr 305 <210> 551 <211> 975 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(975) <400> 551 atg ggc atg gag ggt ctt ctc cag aac tcc act aac ttc gtc ctc aca 48 Met Gly Met Glu Gly Leu Leu Gln Asn Ser Thr Asn Phe Val Leu Thr 1 5 10 15 ggc ctc atc acc cat cct gcc ttc ccc ggg ctt ctc ttt gca ata gtc 96 Gly Leu Ile Thr His Pro Ala Phe Pro Gly Leu Leu Phe Ala Ile Val 20 25 30 ttc tcc atc ttt gtg gtg gct ata aca gcc aac ttg gtc atg att ctg 144 Phe Ser Ile Phe Val Val Ala Ile Thr Ala Asn Leu Val Met Ile Leu 35 40 45 ctc atc cac atg gac tcc cgc ctc cac aca ccc atg tac ttc ttg ctc 192 Leu Ile His Met Asp Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu 50 55 60 agc cag ctc tcc atc atg gat acc atc tac atc tgt atc act gtc ccc 240 Ser Gln Leu Ser Ile Met Asp Thr Ile Tyr Ile Cys Ile Thr Val Pro 65 70 75 80 aag atg ctc cag gac ctc ctg tcc aag gac aag acc att tcc ttc ctg 288 Lys Met Leu Gln Asp Leu Leu Ser Lys Asp Lys Thr Ile Ser Phe Leu 85 90 95 ggc tgt gca gtt cag atc ttc ctc tac ctg acc ctg att gga ggg gaa 336 Gly Cys Ala Val Gln Ile Phe Leu Tyr Leu Thr Leu Ile Gly Gly Glu 100 105 110 ttc ttc ctg ctg ggt ctc atg gcc tat gac cgc tat gtg gct gtg tgc 384 Phe Phe Leu Leu Gly Leu Met Ala Tyr Asp Arg Tyr Val Ala Val Cys 115 120 125 aac cct cta cgg tac cct ctc ctc atg aac cgc agg gtt tgc tta ttc 432 Asn Pro Leu Arg Tyr Pro Leu Leu Met Asn Arg Arg Val Cys Leu Phe 130 135 140 atg gtg gtc ggc tcc tgg gtt ggt ggt tcc ttg gat ggg ttc atg ctg 480 Met Val Val Gly Ser Trp Val Gly Gly Ser Leu Asp Gly Phe Met Leu 145 150 155 160 act cct gtc act atg agt ttc ccc ttc tgt aga tcc cga gag atc aat 528 Thr Pro Val Thr Met Ser Phe Pro Phe Cys Arg Ser Arg Glu Ile Asn 165 170 175 cac ttt ttc tgt gag atc cca gcc gtg ctg aag ttg tct tgc aca gac 576 His Phe Phe Cys Glu Ile Pro Ala Val Leu Lys Leu Ser Cys Thr Asp 180 185 190 acg tca ctc tat gag acc ctg atg tat gcc tgc tgc gtg ctg atg ctg 624 Thr Ser Leu Tyr Glu Thr Leu Met Tyr Ala Cys Cys Val Leu Met Leu 195 200 205 ctt atc cct cta tct gtc atc tct gtc tcc tac acg cac atc ctc ctg 672 Leu Ile Pro Leu Ser Val Ile Ser Val Ser Tyr Thr His Ile Leu Leu 210 215 220 act gtc cac agg atg aac tct gct gag ggc cgg cgc aaa gcc ttt gct 720 Thr Val His Arg Met Asn Ser Ala Glu Gly Arg Arg Lys Ala Phe Ala 225 230 235 240 acg tgt tcc tcc cac att atg gtg gtg agc gtt ttc tac ggg gca gcc 768 Thr Cys Ser Ser His Ile Met Val Val Ser Val Phe Tyr Gly Ala Ala 245 250 255 ttc tac acc aac gtg ctg ccc cac tcc tac cac act cca gag aaa gat 816 Phe Tyr Thr Asn Val Leu Pro His Ser Tyr His Thr Pro Glu Lys Asp 260 265 270 aaa gtg gtg tct gcc ttc tac acc atc ctc acc ccc atg ctc aac cca 864 Lys Val Val Ser Ala Phe Tyr Thr Ile Leu Thr Pro Met Leu Asn Pro 275 280 285 ctc atc tac agc ttg agg aat aaa gat gtg gct gca gct ctg agg aaa 912 Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Ala Ala Ala Leu Arg Lys 290 295 300 gta cta ggg aga tgt ggt tcc tcc cag agc atc agg gtg gcg act gtg 960 Val Leu Gly Arg Cys Gly Ser Ser Gln Ser Ile Arg Val Ala Thr Val 305 310 315 320 atc agg aag ggc tag 975 Ile Arg Lys Gly 325 <210> 552 <211> 324 <212> PRT <213> Homo sapiens <400> 552 Met Gly Met Glu Gly Leu Leu Gln Asn Ser Thr Asn Phe Val Leu Thr 1 5 10 15 Gly Leu Ile Thr His Pro Ala Phe Pro Gly Leu Leu Phe Ala Ile Val 20 25 30 Phe Ser Ile Phe Val Val Ala Ile Thr Ala Asn Leu Val Met Ile Leu 35 40 45 Leu Ile His Met Asp Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu 50 55 60 Ser Gln Leu Ser Ile Met Asp Thr Ile Tyr Ile Cys Ile Thr Val Pro 65 70 75 80 Lys Met Leu Gln Asp Leu Leu Ser Lys Asp Lys Thr Ile Ser Phe Leu 85 90 95 Gly Cys Ala Val Gln Ile Phe Leu Tyr Leu Thr Leu Ile Gly Gly Glu 100 105 110 Phe Phe Leu Leu Gly Leu Met Ala Tyr Asp Arg Tyr Val Ala Val Cys 115 120 125 Asn Pro Leu Arg Tyr Pro Leu Leu Met Asn Arg Arg Val Cys Leu Phe 130 135 140 Met Val Val Gly Ser Trp Val Gly Gly Ser Leu Asp Gly Phe Met Leu 145 150 155 160 Thr Pro Val Thr Met Ser Phe Pro Phe Cys Arg Ser Arg Glu Ile Asn 165 170 175 His Phe Phe Cys Glu Ile Pro Ala Val Leu Lys Leu Ser Cys Thr Asp 180 185 190 Thr Ser Leu Tyr Glu Thr Leu Met Tyr Ala Cys Cys Val Leu Met Leu 195 200 205 Leu Ile Pro Leu Ser Val Ile Ser Val Ser Tyr Thr His Ile Leu Leu 210 215 220 Thr Val His Arg Met Asn Ser Ala Glu Gly Arg Arg Lys Ala Phe Ala 225 230 235 240 Thr Cys Ser Ser His Ile Met Val Val Ser Val Phe Tyr Gly Ala Ala 245 250 255 Phe Tyr Thr Asn Val Leu Pro His Ser Tyr His Thr Pro Glu Lys Asp 260 265 270 Lys Val Val Ser Ala Phe Tyr Thr Ile Leu Thr Pro Met Leu Asn Pro 275 280 285 Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Ala Ala Ala Leu Arg Lys 290 295 300 Val Leu Gly Arg Cys Gly Ser Ser Gln Ser Ile Arg Val Ala Thr Val 305 310 315 320 Ile Arg Lys Gly <210> 553 <211> 1017 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1017) <400> 553 atg ttt tat gta aat cag ata cct ttc caa ctt tat cat atc tct ttc 48 Met Phe Tyr Val Asn Gln Ile Pro Phe Gln Leu Tyr His Ile Ser Phe 1 5 10 15 gtg tac cct aca gag cta tgg agc aga gca att att ccg tgt atg ccg 96 Val Tyr Pro Thr Glu Leu Trp Ser Arg Ala Ile Ile Pro Cys Met Pro 20 25 30 act tta tcc ttc tgg gtt tgt tca gca acg ccc gtt tcc cct ggc ttc 144 Thr Leu Ser Phe Trp Val Cys Ser Ala Thr Pro Val Ser Pro Gly Phe 35 40 45 ttt gcc ctc att ctc ctg gtc ttt gtg acc tcc ata gcc agc aac gtg 192 Phe Ala Leu Ile Leu Leu Val Phe Val Thr Ser Ile Ala Ser Asn Val 50 55 60 gtc aag atc att ctc atc cac ata gac tcc cgc ctc cac acc ccc atg 240 Val Lys Ile Ile Leu Ile His Ile Asp Ser Arg Leu His Thr Pro Met 65 70 75 80 tac ttc ctg ctc agc cag ctc tcc ctc agg gac atc ctg tat att tcc 288 Tyr Phe Leu Leu Ser Gln Leu Ser Leu Arg Asp Ile Leu Tyr Ile Ser 85 90 95 acc att gtg ccc aaa atg ctg gtc gac cag gtg atg agc cag aga gcc 336 Thr Ile Val Pro Lys Met Leu Val Asp Gln Val Met Ser Gln Arg Ala 100 105 110 att tcc ttt gct gga tgc act gcc caa cac ttc ctc tac ttg acc tta 384 Ile Ser Phe Ala Gly Cys Thr Ala Gln His Phe Leu Tyr Leu Thr Leu 115 120 125 gca ggg gct gag ttc ttc ctc cta gga ctc atg tcc tgt gat cgc tac 432 Ala Gly Ala Glu Phe Phe Leu Leu Gly Leu Met Ser Cys Asp Arg Tyr 130 135 140 gta gcc atc tgc aac cct ctg cac tat cct gac ctc atg agc cgc aag 480 Val Ala Ile Cys Asn Pro Leu His Tyr Pro Asp Leu Met Ser Arg Lys 145 150 155 160 atc tgc tgg ttg att gtg gcg gca gcc tgg ctg gga ggg tct atc gat 528 Ile Cys Trp Leu Ile Val Ala Ala Ala Trp Leu Gly Gly Ser Ile Asp 165 170 175 ggt ttc ttg ctc acc ccc gtc acc atg cag ttc ccc ttc tgt gcc tct 576 Gly Phe Leu Leu Thr Pro Val Thr Met Gln Phe Pro Phe Cys Ala Ser 180 185 190 cgg gag atc aac cac ttc ttc tgc gag gtg cct gcc ctt ctg aag ctc 624 Arg Glu Ile Asn His Phe Phe Cys Glu Val Pro Ala Leu Leu Lys Leu 195 200 205 tcc tgc acg gac aca tca gcc tac gag aca gcc atg tat gtc tgc tgt 672 Ser Cys Thr Asp Thr Ser Ala Tyr Glu Thr Ala Met Tyr Val Cys Cys 210 215 220 att atg atg ctc ctc atc cct ttc tct gtg atc tcg ggc tct tac aca 720 Ile Met Met Leu Leu Ile Pro Phe Ser Val Ile Ser Gly Ser Tyr Thr 225 230 235 240 aga att ctc att act gtt tat agg atg agc gag gca gag ggg agg cga 768 Arg Ile Leu Ile Thr Val Tyr Arg Met Ser Glu Ala Glu Gly Arg Arg 245 250 255 aag gct gtg gcc acc tgc tcc tca cac atg gtg gtt gtc agc ctc ttc 816 Lys Ala Val Ala Thr Cys Ser Ser His Met Val Val Val Ser Leu Phe 260 265 270 tat ggg gct gcc atg tac aca tac gtg ctg cct cat tct tac cac acc 864 Tyr Gly Ala Ala Met Tyr Thr Tyr Val Leu Pro His Ser Tyr His Thr 275 280 285 cct gag cag gac aaa gct gta tct gcc ttc tac acc atc ctc act ccc 912 Pro Glu Gln Asp Lys Ala Val Ser Ala Phe Tyr Thr Ile Leu Thr Pro 290 295 300 atg ctc aat cca ctc att tac agc ctt agg aac aag gat gtc acg ggg 960 Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Thr Gly 305 310 315 320 gcc cta cag aag gtt gtt ggg agg tgt gtg tcc tca gga aag gta acc 1008 Ala Leu Gln Lys Val Val Gly Arg Cys Val Ser Ser Gly Lys Val Thr 325 330 335 act ttc taa 1017 Thr Phe <210> 554 <211> 338 <212> PRT <213> Homo sapiens <400> 554 Met Phe Tyr Val Asn Gln Ile Pro Phe Gln Leu Tyr His Ile Ser Phe 1 5 10 15 Val Tyr Pro Thr Glu Leu Trp Ser Arg Ala Ile Ile Pro Cys Met Pro 20 25 30 Thr Leu Ser Phe Trp Val Cys Ser Ala Thr Pro Val Ser Pro Gly Phe 35 40 45 Phe Ala Leu Ile Leu Leu Val Phe Val Thr Ser Ile Ala Ser Asn Val 50 55 60 Val Lys Ile Ile Leu Ile His Ile Asp Ser Arg Leu His Thr Pro Met 65 70 75 80 Tyr Phe Leu Leu Ser Gln Leu Ser Leu Arg Asp Ile Leu Tyr Ile Ser 85 90 95 Thr Ile Val Pro Lys Met Leu Val Asp Gln Val Met Ser Gln Arg Ala 100 105 110 Ile Ser Phe Ala Gly Cys Thr Ala Gln His Phe Leu Tyr Leu Thr Leu 115 120 125 Ala Gly Ala Glu Phe Phe Leu Leu Gly Leu Met Ser Cys Asp Arg Tyr 130 135 140 Val Ala Ile Cys Asn Pro Leu His Tyr Pro Asp Leu Met Ser Arg Lys 145 150 155 160 Ile Cys Trp Leu Ile Val Ala Ala Ala Trp Leu Gly Gly Ser Ile Asp 165 170 175 Gly Phe Leu Leu Thr Pro Val Thr Met Gln Phe Pro Phe Cys Ala Ser 180 185 190 Arg Glu Ile Asn His Phe Phe Cys Glu Val Pro Ala Leu Leu Lys Leu 195 200 205 Ser Cys Thr Asp Thr Ser Ala Tyr Glu Thr Ala Met Tyr Val Cys Cys 210 215 220 Ile Met Met Leu Leu Ile Pro Phe Ser Val Ile Ser Gly Ser Tyr Thr 225 230 235 240 Arg Ile Leu Ile Thr Val Tyr Arg Met Ser Glu Ala Glu Gly Arg Arg 245 250 255 Lys Ala Val Ala Thr Cys Ser Ser His Met Val Val Val Ser Leu Phe 260 265 270 Tyr Gly Ala Ala Met Tyr Thr Tyr Val Leu Pro His Ser Tyr His Thr 275 280 285 Pro Glu Gln Asp Lys Ala Val Ser Ala Phe Tyr Thr Ile Leu Thr Pro 290 295 300 Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Thr Gly 305 310 315 320 Ala Leu Gln Lys Val Val Gly Arg Cys Val Ser Ser Gly Lys Val Thr 325 330 335 Thr Phe <210> 555 <211> 1071 <2 12> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1071) <400> 555 atg tgc tca ggg aat cag act tct cag aat caa aca gca agc act gat 48 Met Cys Ser Gly Asn Gln Thr Ser Gln Asn Gln Thr Ala Ser Thr Asp 1 5 10 15 ttc acc ctc acg gga ctc ttt gct gag agc aag cat gct gcc ctc ctc 96 Phe Thr Leu Thr Gly Leu Phe Ala Glu Ser Lys His Ala Ala Leu Leu 20 25 30 tac acc gtg acc ttc ctt ctt ttc ttg atg gcc ctc act ggg aat gcc 144 Tyr Thr Val Thr Phe Leu Leu Phe Leu Met Ala Leu Thr Gly Asn Ala 35 40 45 ctc ctc atc ctc ctc atc cac tca gag ccc cgc ctc cac acc ccc atg 192 Leu Leu Ile Leu Leu Ile His Ser Glu Pro Arg Leu His Thr Pro Met 50 55 60 tac ttc ttc atc agc cag ctc gcg ctc atg gat ctc atg tac cta tgc 240 Tyr Phe Phe Ile Ser Gln Leu Ala Leu Met Asp Leu Met Tyr Leu Cys 65 70 75 80 gtg act gtg ccc aag atg ctt gtg ggc cag gtc act gga gat gat acc 288 Val Thr Val Pro Lys Met Leu Val Gly Gln Val Thr Gly Asp Asp Thr 85 90 95 att tcc ccg tca ggc tgt ggg atc cag atg ttc ttc tac ctg acc ctg 336 Ile Ser Pro Ser Gly Cys Gly Ile Gln Met Phe Phe Tyr Leu Thr Leu 100 105 110 gct gga gct gag gtt ttc ctc ctg gct gcc atg gcc tat gac cga tat 384 Ala Gly Ala Glu Val Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr 115 120 125 gct gct gtt tgc aga cct ctc cat tac cca ctg ctg atg aac cag agg 432 Ala Ala Val Cys Arg Pro Leu His Tyr Pro Leu Leu Met Asn Gln Arg 130 135 140 gtg tgc cag ctc ctg gtg tca gcc tgc tgg gtt ttg gga atg gtt gat 480 Val Cys Gln Leu Leu Val Ser Ala Cys Trp Val Leu Gly Met Val Asp 145 150 155 160 ggt ttg ttg ctc acc ccc att acc atg agc ttc ccc ttt tgc cag tct 528 Gly Leu Leu Leu Thr Pro Ile Thr Met Ser Phe Pro Phe Cys Gln Ser 165 170 175 agg aaa atc ctg agt ttt ttc tgt gag act cct gcc ctg ctg aag ctc 576 Arg Lys Ile Leu Ser Phe Phe Cys Glu Thr Pro Ala Leu Leu Lys Leu 180 185 190 tcc tgc tct gac gtc tcc ctc tat aag acg ctc atg tac ctg tgc tgc 624 Ser Cys Ser Asp Val Ser Leu Tyr Lys Thr Leu Met Tyr Leu Cys Cys 195 200 205 atc ctc atg ctt ctc gcc ccc atc atg gtc atc tcc agc tca tac acc 672 Ile Leu Met Leu Leu Ala Pro Ile Met Val Ile Ser Ser Ser Tyr Thr 210 215 220 ctc atc ctg cat ctc atc cac agg atg aat tct gcc gcc ggc cac agg 720 Leu Ile Leu His Leu Ile His Arg Met Asn Ser Ala Ala Gly His Arg 225 230 235 240 aag gcc ttg gcc acc tgc tcc tcc cac atg atc ata gtg ctg ctg ctc 768 Lys Ala Leu Ala Thr Cys Ser Ser His Met Ile Ile Val Leu Leu Leu 245 250 255 ttc ggt gct tcc ttc tac acc tac atg ctc ccg agt tcc tac cac aca 816 Phe Gly Ala Ser Phe Tyr Thr Tyr Met Leu Pro Ser Ser Tyr His Thr 260 265 270 gct gag cag gac atg atg gtg tct gcc ttt tac acc atc ttc act cct 864 Ala Glu Gln Asp Met Met Val Ser Ala Phe Tyr Thr Ile Phe Thr Pro 275 280 285 gtg ctg aac ccc ctc att tac agt ctc cgc aac aaa gat gtc acc agg 912 Val Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Thr Arg 290 295 300 gct atg agg agc atg atg cag tca aga ann nnn nnn nnn nnn nnn nnn 960 Ala Met Arg Ser Met Met Gln Ser Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa 305 310 315 320 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 1008 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 325 330 335 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnt tat tgc tcc cat tca 1056 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Cys Ser His Ser 340 345 350 tct cat cag att taa 1071 Ser His Gln Ile 355 <210> 556 <211> 356 <212> PRT <213> Homo sapiens <400> 556 Met Cys Ser Gly Asn Gln Thr Ser Gln Asn Gln Thr Ala Ser Thr Asp 1 5 10 15 Phe Thr Leu Thr Gly Leu Phe Ala Glu Ser Lys His Ala Ala Leu Leu 20 25 30 Tyr Thr Val Thr Phe Leu Leu Phe Leu Met Ala Leu Thr Gly Asn Ala 35 40 45 Leu Leu Ile Leu Leu Ile His Ser Glu Pro Arg Leu His Thr Pro Met 50 55 60 Tyr Phe Phe Ile Ser Gln Leu Ala Leu Met Asp Leu Met Tyr Leu Cys 65 70 75 80 Val Thr Val Pro Lys Met Leu Val Gly Gln Val Thr Gly Asp Asp Thr 85 90 95 Ile Ser Pro Ser Gly Cys Gly Ile Gln Met Phe Phe Tyr Leu Thr Leu 100 105 110 Ala Gly Ala Glu Val Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr 115 120 125 Ala Ala Val Cys Arg Pro Leu His Tyr Pro Leu Leu Met Asn Gln Arg 130 135 140 Val Cys Gln Leu Leu Val Ser Ala Cys Trp Val Leu Gly Met Val Asp 145 150 155 160 Gly Leu Leu Leu Thr Pro Ile Thr Met Ser Phe Pro Phe Cys Gln Ser 165 170 175 Arg Lys Ile Leu Ser Phe Phe Cys Glu Thr Pro Ala Leu Leu Lys Leu 180 185 190 Ser Cys Ser Asp Val Ser Leu Tyr Lys Thr Leu Met Tyr Leu Cys Cys 195 200 205 Ile Leu Met Leu Leu Ala Pro Ile Met Val Ile Ser Ser Ser Tyr Thr 210 215 220 Leu Ile Leu His Leu Ile His Arg Met Asn Ser Ala Ala Gly His Arg 225 230 235 240 Lys Ala Leu Ala Thr Cys Ser Ser His Met Ile Ile Val Leu Leu Leu 245 250 255 Phe Gly Ala Ser Phe Tyr Thr Tyr Met Leu Pro Ser Ser Tyr His Thr 260 265 270 Ala Glu Gln Asp Met Met Val Ser Ala Phe Tyr Thr Ile Phe Thr Pro 275 280 285 Val Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Thr Arg 290 295 300 Ala Met Arg Ser Met Met Gln Ser Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa 305 310 315 320 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 325 330 335 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Cys Ser His Ser 340 345 350 Ser His Gln Ile 355 <210> 557 <211> 843 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(843) <400> 557 atg gcg ttg tct gga aat gct gtc ctg atc ctt ctg ata cac tgt gac 48 Met Ala Leu Ser Gly Asn Ala Val Leu Ile Leu Leu Ile His Cys Asp 1 5 10 15 gcc cac ctc cac acc ccc atg tac ttt ttc atc agt caa ttg tct ctc 96 Ala His Leu His Thr Pro Met Tyr Phe Phe Ile Ser Gln Leu Ser Leu 20 25 30 atg gac atg gcg tac att tct gtc act gtg ccc aag atg ctc ctg gac 144 Met Asp Met Ala Tyr Ile Ser Val Thr Val Pro Lys Met Leu Leu Asp 35 40 45 cag gtc atg ggt gtg aat aag atc tca gcc cct gag tgt ggg atg cag 192 Gln Val Met Gly Val Asn Lys Ile Ser Ala Pro Glu Cys Gly Met Gln 50 55 60 atg ttc ttc tac gtg aca cta gca ggt tca gaa ttt ttc ctt cta gcc 240 Met Phe Phe Tyr Val Thr Leu Ala Gly Ser Glu Phe Phe Leu Leu Ala 65 70 75 80 acc atg gcc tat gac cgc tac gtg gcc atc tgc cat cct ctc cgt tac 288 Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr 85 90 95 cct gtc ctc atg aac cat agg gtg tgt ctc ttc ctg tca tca ggc tgc 336 Pro Val Leu Met Asn His Arg Val Cys Leu Phe Leu Ser Ser Gly Cys 100 105 110 tgg ttc ctg ggc tca gtg gat ggc ttc aca ttc act ccc atc acc atg 384 Trp Phe Leu Gly Ser Val Asp Gly Phe Thr Phe Thr Pro Ile Thr Met 115 120 125 acc ttc ccc ttc cgt gga tcc cgg gag att cat cat ttc ttc tgt gaa 432 Thr Phe Pro Phe Arg Gly Ser Arg Glu Ile His His Phe Phe Cys Glu 130 135 140 gtt cct gct gta ttg aat ctc tcc tgc tca gac acc tca ctc tat gag 480 Va l Pro Ala Val Leu Asn Leu Ser Cys Ser Asp Thr Ser Leu Tyr Glu 145 150 155 160 att ttc atg tac ttg tgc tgt gtc ctc atg ctc ctc atc cct gtg gtg 528 Ile Phe Met Tyr Leu Cys Cys Val Leu Met Leu Leu Ile Pro Val Val 165 170 175 atc att tca agc tcc tat tta ctc atc ctc ctc acc atc cac ggg atg 576 Ile Ile Ser Ser Ser Tyr Leu Leu Ile Leu Leu Thr Ile His Gly Met 180 185 190 aac tca gca gag ggc cgg aaa aag gcc ttt gcc acc tgc tcc tcc cac 624 Asn Ser Ala Glu Gly Arg Lys Lys Ala Phe Ala Thr Cys Ser Ser His 195 200 205 ctg act gtg gtc atc ctc ttc tat ggg gct gcc atc tac acc tac atg 672 Leu Thr Val Val Ile Leu Phe Tyr Gly Ala Ala Ile Tyr Thr Tyr Met 210 215 220 ctc ccc agc tcc tac cac acc cct gag aag gac atg atg gta tct gtc 720 Leu Pro Ser Ser Tyr His Thr Pro Glu Lys Asp Met Met Val Ser Val 225 230 235 240 ttc tat acc atc ctc act cca gtg gtg aac cct tta atc tat agt ctt 768 Phe Tyr Thr Ile Leu Thr Pro Val Val Asn Pro Leu Ile Tyr Ser Leu 245 250 255 agg aat aag gat gtc atg ggg gct ctg aag aaa atg tta aca gtg gaa 816 Arg Asn Lys Asp Val Met Gly Ala Leu Lys Lys Met Leu Thr Val Glu 260 265 270 cct gcc ttt caa aaa gct atg gag tag 843 Pro Ala Phe Gln Lys Ala Met Glu 275 280 <210> 558 <211> 280 <212> PRT <213> Homo sapiens <400> 558 Met Ala Leu Ser Gly Asn Ala Val Leu Ile Leu Leu Ile His Cys Asp 1 5 10 15 Ala His Leu His Thr Pro Met Tyr Phe Phe Ile Ser Gln Leu Ser Leu 20 25 30 Met Asp Met Ala Tyr Ile Ser Val Thr Val Pro Lys Met Leu Leu Asp 35 40 45 Gln Val Met Gly Val Asn Lys Ile Ser Ala Pro Glu Cys Gly Met Gln 50 55 60 Met Phe Phe Tyr Val Thr Leu Ala Gly Ser Glu Phe Phe Leu Leu Ala 65 70 75 80 Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr 85 90 95 Pro Val Leu Met Asn His Arg Val Cys Leu Phe Leu Ser Ser Gly Cys 100 105 110 Trp Phe Leu Gly Ser Val Asp Gly Phe Thr Phe Thr Pro Ile Thr Met 115 120 125 Thr Phe Pro Phe Arg Gly Ser Arg Glu Ile His His Phe Phe Cys Glu 130 135 140 Val Pro Ala Val Leu Asn Leu Ser Cys Ser Asp Thr Ser Leu Tyr Glu 145 150 155 160 Ile Phe Met Tyr Leu Cys Cys Val Leu Met Leu Leu Ile Pro Val Val 165 170 175 Ile Ile Ser Ser Ser Tyr Leu Leu Ile Leu Leu Thr Ile His Gly Met 180 185 190 Asn Ser Ala Glu Gly Arg Lys Lys Ala Phe Ala Thr Cys Ser Ser His 195 200 205 Leu Thr Val Val Ile Leu Phe Tyr Gly Ala Ala Ile Tyr Thr Tyr Met 210 215 220 Leu Pro Ser Ser Tyr His Thr Pro Glu Lys Asp Met Met Val Ser Val 225 230 235 240 Phe Tyr Thr Ile Leu Thr Pro Val Val Asn Pro Leu Ile Tyr Ser Leu 245 250 255 Arg Asn Lys Asp Val Met Gly Ala Leu Lys Lys Met Leu Thr Val Glu 260 265 270 Pro Ala Phe Gln Lys Ala Met Glu 275 280 <210> 559 <211> 939 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(939) <400> 559 atg ccc aat tca acc acc gtg atg gaa ttt ctc ctc atg agg ttt tct 48 Met Pro Asn Ser Thr Thr Val Met Glu Phe Leu Leu Met Arg Phe Ser 1 5 10 15 gat gtg tgg aca cta cag att tta cat tct gca tcc ttc ttt atg ttg 96 Asp Val Trp Thr Leu Gln Ile Leu His Ser Ala Ser Phe Phe Met Leu 20 25 30 tat ttg gta act cta atg gga aac atc ctc att gtg acc gtc acc acc 144 Tyr Leu Val Thr Leu Met Gly Asn Ile Leu Ile Val Thr Val Thr Thr 35 40 45 tgt gac agc agc ctt cac atg ccc atg tac ttc ttc ctc agg aat ctg 192 Cys Asp Ser Ser Leu His Met Pro Met Tyr Phe Phe Leu Arg Asn Leu 50 55 60 tct atc ttg gat gcc tgc tac att tct gtt aca gtc cct acc tca tgt 240 Ser Ile Leu Asp Ala Cys Tyr Ile Ser Val Thr Val Pro Thr Ser Cys 65 70 75 80 gtc aat tcc cta ctg gac agc acc acc att tct aag gcg gga tgt gta 288 Val Asn Ser Leu Leu Asp Ser Thr Thr Ile Ser Lys Ala Gly Cys Val 85 90 95 gct cag gtc ttc ctc gtg gtt ttt ttt gta tat gtg gag ctt ctg ttt 336 Ala Gln Val Phe Leu Val Val Phe Phe Val Tyr Val Glu Leu Leu Phe 100 105 110 ctc acc att atg gct cat gac cgc tat gtg gct gtc tgc cag cca ctt 384 Leu Thr Ile Met Ala His Asp Arg Tyr Val Ala Val Cys Gln Pro Leu 115 120 125 cac tac cct gtg atc gtg aac tct cga atc tgc atc cag atg aca ctg 432 His Tyr Pro Val Ile Val Asn Ser Arg Ile Cys Ile Gln Met Thr Leu 130 135 140 gcc tcc cta ctc agt ggt ctt gtc tat gca ggc atg cac act ggc agc 480 Ala Ser Leu Leu Ser Gly Leu Val Tyr Ala Gly Met His Thr Gly Ser 145 150 155 160 aca ttc cag ctg ccc ttc tgt cgg tcc aac gtt att cat caa ttc ttc 528 Thr Phe Gln Leu Pro Phe Cys Arg Ser Asn Val Ile His Gln Phe Phe 165 170 175 tgt gac atc ccc tct ctg ctg aag ctc tct tgc tct gac acc ttc agc 576 Cys Asp Ile Pro Ser Leu Leu Lys Leu Ser Cys Ser Asp Thr Phe Ser 180 185 190 aa t gag gtc atg att gtt gtc tct gct ctg ggg gta ggt ggc ggc tgt 624 Asn Glu Val Met Ile Val Val Ser Ala Leu Gly Val Gly Gly Gly Cys 195 200 205 ttc atc ttt atc atc agg tct tac att cac atc ttt tcg acc gtg ctc 672 Phe Ile Phe Ile Ile Arg Ser Tyr Ile His Ile Phe Ser Thr Val Leu 210 215 220 ggg ttt cca aga gga gca gac aga aca aag gcc ttt tcc acc tgc atc 720 Gly Phe Pro Arg Gly Ala Asp Arg Thr Lys Ala Phe Ser Thr Cys Ile 225 230 235 240 cct cac atc ctg gtg gtg tca gtc ttc ctc agt tca tgc tct tct gtg 768 Pro His Ile Leu Val Val Ser Val Phe Leu Ser Ser Cys Ser Ser Val 245 250 255 tac ctc agg cca cct gcg ata cct gca gcc acc cag gat ctg atc ctt 816 Tyr Leu Arg Pro Pro Ala Ile Pro Ala Ala Thr Gln Asp Leu Ile Leu 260 265 270 tct ggt ttt tat tcc ata atg cct ccc ctc ttt aac cct att att tac 864 Ser Gly Phe Tyr Ser Ile Met Pro Pro Leu Phe Asn Pro Ile Ile Tyr 275 280 285 agt ctt aga aat aag caa ata aag gtg gcc atc aag aaa atc atg aag 912 Ser Leu Arg Asn Lys Gln Ile Lys Val Ala Ile Lys Lys Ile Met Lys 290 295 300 aga att ttt tat tca gaa aat gtg taa 939 Arg Ile Phe Tyr Ser Glu Asn Val 305 310 <210> 560 <211> 312 <212> PRT <213> Homo sapiens <400> 560 Met Pro Asn Ser Thr Thr Val Met Glu Phe Leu Leu Met Arg Phe Ser 1 5 10 15 Asp Val Trp Thr Leu Gln Ile Leu His Ser Ala Ser Phe Phe Met Leu 20 25 30 Tyr Leu Val Thr Leu Met Gly Asn Ile Leu Ile Val Thr Val Thr Thr 35 40 45 Cys Asp Ser Ser Leu His Met Pro Met Tyr Phe Phe Leu Arg Asn Leu 50 55 60 Ser Ile Leu Asp Ala Cys Tyr Ile Ser Val Thr Val Pro Thr Ser Cys 65 70 75 80 Val Asn Ser Leu Leu Asp Ser Thr Thr Ile Ser Lys Ala Gly Cys Val 85 90 95 Ala Gln Val Phe Leu Val Val Phe Phe Val Tyr Val Glu Leu Leu Phe 100 105 110 Leu Thr Ile Met Ala His Asp Arg Tyr Val Ala Val Cys Gln Pro Leu 115 120 125 His Tyr Pro Val Ile Val Asn Ser Arg Ile Cys Ile Gln Met Thr Leu 130 135 140 A la Ser Leu Leu Ser Gly Leu Val Tyr Ala Gly Met His Thr Gly Ser 145 150 155 160 Thr Phe Gln Leu Pro Phe Cys Arg Ser Asn Val Ile His Gln Phe Phe 165 170 175 Cys Asp Ile Pro Ser Leu Leu Lys Leu Ser Cys Ser Asp Thr Phe Ser 180 185 190 Asn Glu Val Met Ile Val Val Ser Ala Leu Gly Val Gly Gly Gly Cys 195 200 205 Phe Ile Phe Ile Ile Arg Ser Tyr Ile His Ile Phe Ser Thr Val Leu 210 215 220 Gly Phe Pro Arg Gly Ala Asp Arg Thr Lys Ala Phe Ser Thr Cys Ile 225 230 235 240 Pro His Ile Leu Val Val Ser Val Phe Leu Ser Ser Cys Ser Ser Val 245 250 255 Tyr Leu Arg Pro Pro Ala Ile Pro Ala Ala Thr Gln Asp Leu Ile Leu 260 265 270 Ser Gly Phe Tyr Ser Ile Met Pro Pro Leu Phe Asn Pro Ile Ile Tyr 275 280 285 Ser Leu Arg Asn Lys Gln Ile Lys Val Ala Ile Lys Lys Ile Met Lys 290 295 300 Arg Ile Phe Tyr Ser Glu Asn Val 305 310 <210> 561 <211> 948 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(948) <400> 561 atg gcc aac atc acc agg atg gcc aac cac act gga aag ttg gat ttc 48 Met Ala Asn Ile Thr Arg Met Ala Asn His Thr Gly Lys Leu Asp Phe 1 5 10 15 atc ctc atg gga ctc ttc aga cga tcc aaa cat cca gct cta ctt agt 96 Ile Leu Met Gly Leu Phe Arg Arg Ser Lys His Pro Ala Leu Leu Ser 20 25 30 gtg gtc atc ttt gtg gtt ttc ctg aag gcg ttg tct gga aat gct gtc 144 Val Val Ile Phe Val Val Phe Leu Lys Ala Leu Ser Gly Asn Ala Val 35 40 45 ctg atc ctt ctg ata cac tgt gac gcc cac ctc cac agc ccc atg tac 192 Leu Ile Leu Leu Ile His Cys Asp Ala His Leu His Ser Pro Met Tyr 50 55 60 ttt ttc atc agt caa ttg tct ctc atg gac atg gcg tac att tct gtc 240 Phe Phe Ile Ser Gln Leu Ser Leu Met Asp Met Ala Tyr Ile Ser Val 65 70 75 80 a ct gtg ccc aag atg ctc ctg gac cag gtc atg ggt gtg aat aag gtc 288 Thr Val Pro Lys Met Leu Leu Asp Gln Val Met Gly Val Asn Lys Val 85 90 95 tca gcc cct gag tgt ggg atg cag atg ttc ctc tat ctg aca cta gca 336 Ser Ala Pro Glu Cys Gly Met Gln Met Phe Leu Tyr Leu Thr Leu Ala 100 105 110 ggt tcg gaa ttt ttc ctt cta gcc acc atg gcc tat gac cgc tac gtg 384 Gly Ser Glu Phe Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val 115 120 125 gcc atc tgc cat cct ctc cgt tac cct gtc ctc atg aac cat agg gtc 432 Ala Ile Cys His Pro Leu Arg Tyr Pro Val Leu Met Asn His Arg Val 130 135 140 tgt ctt ttc ctg gca tcg ggc tgc tgg ttc ctg ggc tca gtg gat ggc 480 Cys Leu Phe Leu Ala Ser Gly Cys Trp Phe Leu Gly Ser Val Asp Gly 145 150 155 160 ttc atg ctc act ccc atc acc atg agc ttc ccc ttc tgc aga tcc tgg 528 Phe Met Leu Thr Pro Ile Thr Met Ser Phe Pro Phe Cys Arg Ser Trp 165 170 175 gag att cat cat ttc ttc tgt gaa gtc cct gct gta acg atc ctg tcc 576 Glu Ile His His Phe Phe Cys Glu Val Pro Ala Val Thr Ile Leu Ser 180 185 190 tgc tca gac acc tca ctc tat gag acc ctc atg tac cta tgc tgt gtc 624 Cys Ser Asp Thr Ser Leu Tyr Glu Thr Leu Met Tyr Leu Cys Cys Val 195 200 205 ctc atg ctc ctc atc cct gtg acg atc att tca agc tcc tat tta ctc 672 Leu Met Leu Leu Ile Pro Val Thr Ile Ile Ser Ser Ser Tyr Leu Leu 210 215 220 atc ctc ctc acc gtc cac agg atg aac tca gca gag ggc cgg aaa aag 720 Ile Leu Leu Thr Val His Arg Met Asn Ser Ala Glu Gly Arg Lys Lys 225 230 235 240 gcc ttt gcc acc tgc tcc tcc cac ctg act gtg gtc atc ctc ttc tat 768 Ala Phe Ala Thr Cys Ser Ser His Leu Thr Val Val Ile Leu Phe Tyr 245 250 255 ggg gct gcc gtc tac acc tac atg ctc ccc agc tcc tac cac acc cct 816 Gly Ala Ala Val Tyr Thr Tyr Met Leu Pro Ser Ser Tyr His Thr Pro 260 265 270 gag aag gac atg atg gta tct gtc ttc tat acc atc ctc act ccg gtg 864 Glu Lys Asp Met Met Val Ser Val Phe Tyr Thr Ile Leu Thr Pro Val 275 280 285 ctg aac cct tta atc tat agt ctt agg aat aag gat gtc atg ggg gct 912 Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Met Gly Ala 290 295 300 ctg aag aaa atg tta act gtg aga ttc gtc ctt tag 948 Leu Lys Lys Met Leu Thr Val Arg Phe Val Leu 305 310 315 <210> 562 <211> 315 <212> PRT <213> Homo sapiens <400> 562 Met Ala Asn Ile Thr Arg Met Ala Asn His Thr Gly Lys Leu Asp Phe 1 5 10 15 Ile Leu Met Gly Leu Phe Arg Arg Ser Lys His Pro Ala Leu Leu Ser 20 25 30 Val Val Ile Phe Val Val Phe Leu Lys Ala Leu Ser Gly Asn Ala Val 35 40 45 Leu Ile Leu Leu Ile His Cys Asp Ala His Leu His Ser Pro Met Tyr 50 55 60 Phe Phe Ile Ser Gln Leu Ser Leu Met Asp Met Ala Tyr Ile Ser Val 65 70 75 80 Thr Val Pro Lys Met Leu Leu Asp Gln Val Met Gly Val Asn Lys Val 85 90 95 Ser Ala Pro Glu Cys Gly Met Gln Met Phe Leu Tyr Leu Thr Leu Ala 100 105 110 Gly Ser Glu Phe Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val 115 120 125 Ala Ile Cys His Pro Leu Arg Tyr Pro Val Leu Met Asn His Arg Val 130 135 140 Cys Leu Phe Leu Ala Ser Gly Cys Trp Phe Leu Gly Ser Val Asp Gly 145 150 155 160 Phe Met Leu Thr Pro Ile Thr Met Ser Phe Pro Phe Cys Arg Ser Trp 165 170 175 Glu Ile His His Phe Phe Cys Glu Val Pro Ala Val Thr Ile Leu Ser 180 185 190 Cys Ser Asp Thr Ser Leu Tyr Glu Thr Leu Met Tyr Leu Cys Cys Val 195 200 205 Leu Met Leu Leu Ile Pro Val Thr Ile Ile Ser Ser Ser Tyr Leu Leu 210 215 220 Ile Leu Leu Thr Val His Arg Met Asn Ser Ala Glu Gly Arg Lys Lys 225 230 235 240 Ala Phe Ala Thr Cys Ser Ser His Leu Thr Val Val Ile Leu Phe Tyr 245 250 255 Gly Ala Ala Val Tyr Thr Tyr Met Leu Pro Ser Ser Tyr His Thr Pro 260 265 270 Glu Lys Asp Met Met Val Ser Val Phe Tyr Thr Ile Leu Thr Pro Val 275 280 285 Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Met Gly Ala 290 295 300 Leu Lys Lys Met Leu Thr Val Arg Phe Val Leu 305 310 315 <210> 563 <211> 939 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(939) <400> 563 atg gag ccg ctc aac aga aca gag gtg tcc gag ttc ttt ctg aaa gga 48 Met Glu Pro Leu Asn Arg Thr Glu Val Ser Glu Phe Phe Leu Lys Gly 1 5 10 15 ttt tct ggc tac cca gcc ctg gag cat ctg ctc ttc cct ctg tgc tca 96 Phe Ser Gly Tyr Pro Ala Leu Glu His Leu Leu Phe Pro Leu Cys Ser 20 25 30 gcc atg tac ctg gtg acc ctc ctg ggg aac aca gcc atc atg gcg gtg 144 Ala Met Tyr Leu Val Thr Leu Leu Gly Asn Thr Ala Ile Met Ala Val 35 40 45 agc gtg cta gat atc cac ctg cac acg ccc gtg tac ttc ttc ctg ggc 192 Ser Val Leu Asp Ile His Leu His Thr Pro Val Tyr Phe Phe Leu Gly 50 55 60 aac ctc tct acc ctg gac atc tgc tac acg ccc acc ttt gtg cct ctg 240 Asn Leu Ser Thr Leu Asp Ile Cys Tyr Thr Pro Thr Phe Val Pro Leu 65 70 75 80 atg ctg gtc cac ctc ctg tca tcc cgg aag acc atc tcc ttt gct gtc 288 Met Leu Val His Leu Leu Ser Ser Arg Lys Thr Ile Ser Phe Ala Val 85 90 95 tgt gcc atc cag atg tgt ctg agc ctg tcc acg ggc tcc acg gag tgc 336 Cys Ala Ile Gln Met Cys Leu Ser Leu Ser Thr Gly Ser Thr Glu Cys 100 105 110 ctg cta ctg gcc atc acg gcc tat gac cgc tac ctg gcc atc tgc cag 384 Leu Leu Leu Ala Ile Thr Ala Tyr Asp Arg Tyr Leu Ala Ile Cys Gln 115 120 125 cca ctc agg tac cac gtg ctc atg agc cac cgg ctc tgc gtg ctg ctg 432 Pro Leu Arg Tyr His Val Leu Met Ser His Arg Leu Cys Val Leu Leu 130 135 140 atg gga gct gcc tgg gtc ctc tgc ctc ctc aag tcg gtg act gag atg 480 Met Gly Ala Ala Trp Val Leu Cys Leu Leu Lys Ser Val Thr Glu Met 145 150 155 160 gtc atc tcc atg agg ctg ccc ttc tgt ggc cac cac gtg gtc agt cac 528 Val Ile Ser Met Arg Leu Pro Phe Cys Gly His His Val Val Ser His 165 170 175 ttc acc tgc aag atc ctg gca gtg ctg aag ctg gca tgc ggc aac acg 576 Phe Thr Cys Lys Ile Leu Ala Val Leu Lys Leu Ala Cys Gly Asn Thr 180 185 190 tcg gtc agc gaa gac ttc ctg ctg gcg ggc tcc atc ctg ctg ctg cct 624 Ser Val Ser Glu Asp Phe Leu Leu Ala Gly Ser Ile Leu Leu Leu Pro 195 200 205 gta ccc ctg gca ttc atc tgc ctg tcc tac ttg ctc atc ctg gcc acc 672 Val Pro Leu Ala Phe Ile Cys Leu Ser Tyr Leu Leu Ile Leu Ala Thr 210 215 220 atc ctg agg gtg ccc tcg gcc gcc agg tgc tgc aaa gcc ttc tcc acc 720 Ile Leu Arg Val Pro Ser Ala Ala Arg Cys Cys Lys Ala Phe Ser Thr 225 230 235 240 tgc ttg gca cac ctg gct gta gtg ctg ctt ttc tac ggc acc atc atc 768 Cys Leu Ala His Leu Ala Val Val Leu Leu Phe Tyr Gly Thr Ile Ile 245 250 255 ttc atg tac ttg aag ccc aag agt aag gaa gcc cac atc tct gat gag 816 Phe Met Tyr Leu Lys Pro Lys Ser Lys Glu Ala His Ile Ser Asp Glu 260 265 270 gtc ttc aca gtc ctc tat gcc atg gtc acg acc atg ctg aac ccc acc 864 Val Phe Thr Val Leu Tyr Ala Met Val Thr Thr Met Leu Asn Pro Thr 275 280 285 atc tac agc ctg agg aac aag gag gtg aag gag gcc gcc agg aag gtg 912 Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Glu Ala Ala Arg Lys Val 290 295 300 tgg ggc agg agt cgg gcc tcc agg tga 939 Trp Gly Arg Ser Arg Ala Ser Arg 305 310 <210> 564 <211> 312 <212> PRT <213> Homo sapiens <400> 564 Met Glu Pro Leu Asn Arg Thr Glu Val Ser Glu Phe Phe Leu Lys Gly 1 5 10 15 Phe Ser Gly Tyr Pro Ala Leu Glu His Leu Leu Phe Pro Leu Cys Ser 20 25 30 Ala Met Tyr Leu Val Thr Leu Leu Gly Asn Thr Ala Ile Met Ala Val 35 40 45 Ser Val Leu Asp Ile His Leu His Thr Pro Val Tyr Phe Phe Leu Gly 50 55 60 Asn Leu Ser Thr Leu Asp Ile Cys Tyr Thr Pro Thr Phe Val Pro Leu 65 70 75 80 Met Leu Val His Leu Leu Ser Ser Arg Lys Thr Ile Ser Phe Ala Val 85 90 95 Cys Ala Ile Gln Met Cys Leu Ser Leu Ser Thr Gly Ser Thr Glu Cys 100 105 110 Leu Leu Leu Ala Ile Thr Ala Tyr Asp Arg Tyr Leu Ala Ile Cys Gln 115 120 125 Pro Leu Arg Tyr His Val Leu Met Ser His Arg Leu Cys Val Leu Leu 130 135 140 Met Gly Ala Ala Trp Val Leu Cys Leu Leu Lys Ser Val Thr Glu Met 145 150 155 160 Val Ile Ser Met Arg Leu Pro Phe Cys Gly His His Val Val Ser His 165 170 175 Phe Thr Cys Lys Ile Leu Ala Val Leu Lys Leu Ala Cys Gly Asn Thr 180 185 190 Ser Val Ser Glu Asp Phe Leu Leu Ala Gly Ser Ile Leu Leu Leu Pro 195 200 205 Val Pro Leu Ala Phe Ile Cys Leu Ser Tyr Leu Leu Ile Leu Ala Thr 210 215 220 Ile Leu Arg Val Pro Ser Ala Ala Arg Cys Cys Lys Ala Phe Ser Thr 225 230 235 240 Cys Leu Ala His Leu Ala Val Val Leu Leu Phe Tyr Gly Thr Ile Ile 245 250 255 Phe Met Tyr Leu Lys Pro Lys Ser Lys Glu Ala His Ile Ser Asp Glu 260 265 270 Val Phe Thr Val Leu Tyr Ala Met Val Thr Thr Met Leu Asn Pro Thr 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Glu Ala Ala Arg Lys Val 290 295 300 Trp Gly Arg Ser Arg Ala Ser Arg 305 310 <210> 565 <211> 942 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(942) <400> 565 atg gag caa gtc aat aag act gtg gtg aga gag ttc gtc gtc ctc ggc 48 Met Glu Gln Val Asn Lys Thr Val Val Arg Glu Phe Val Val Leu Gly 1 5 10 15 ttc tca tcc ctg gcc agg ctg cag cag ctg ctc ttt gtt atc ttc ctg 96 Phe Ser Ser Leu Ala Arg Leu Gln Gln Leu Leu Phe Val Ile Phe Leu 20 25 30 ctc ctc tac ctg ttc act ctg ggc acc aat gca atc atc att tcc acc 144 Leu Leu Tyr Leu Phe Thr Leu Gly Thr Asn Ala Ile Ile Ile Ser Thr 35 40 45 att gtg ctg gac aga gcc ctt cat act ccc atg tac ttc ttc ctt gcc 192 Ile Val Leu Asp Arg Ala Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 atc ctt tct tgc tct gag att tgc tat acc ttt gtc att gta ccc aag 240 Ile Leu Ser Cys Ser Glu Ile Cys Tyr Thr Phe Val Ile Val Pro Lys 65 70 75 80 atg ctg gtt gac ctg ctg tcc cag aag aag acc att tct ttc ctg ggc 288 Met Leu Val Asp Leu Leu Ser Gln Lys Lys Thr Ile Ser Phe Leu Gly 85 90 95 tgt gcc atc caa atg ttt tcc ttc ctc ttc ttt ggc tcc tct cac tcc 336 Cys Ala Ile Gln Met Phe Ser Phe Leu Phe Phe Gly Ser Ser His Ser 100 105 110 ttc ctg ctg gca gcc atg ggc tat gat cgc tat atg gcc atc tgt aac 384 Phe Leu Leu Ala Ala Met Gly Tyr Asp Arg Tyr Met Ala Ile Cys Asn 115 120 125 cca ctg cgc tac tca gtg ctc atg gga cat ggg gtg tgt atg gga cta 432 Pro Leu Arg Tyr Ser Val Leu Met Gly His Gly Val Cys Met Gly Leu 130 135 140 atg gct gct gcc tgt gcc tgt ggc ttc act gtc tcc ctg gtc acc acc 480 Met Ala Ala Ala Cys Ala Cys Gly Phe Thr Val Ser Leu Val Thr Thr 145 150 155 160 tcc cta gta ttt cat ctg ccc ttc cac tcc tcc aac cag ctc cat cac 528 Ser Leu Val Phe His Leu Pro Phe His Ser Ser Asn Gln Leu His His 165 170 175 ttc ttc tgt gac atc tcc cct gtc ctt aaa ctg gca tct cag cac tcc 576 Phe Phe Cys Asp Ile Ser Pro Val Leu Lys Leu Ala Ser Gln His Ser 180 185 190 ggc ttc agt cag ctg gtc ata ttc atg ctt ggt gta ttt gcc ttg gtc 624 Gly Phe Ser Gln Leu Val Ile Phe Met Leu Gly Val Phe Ala Leu Val 195 200 205 att cct ctg cta ctt atc cta gtc tcc tac atc cgc atc atc tct gcc 672 Ile Pro Leu Leu Leu Ile Leu Val Ser Tyr Ile Arg Ile Ile Ser Ala 210 215 220 att cta aaa atc cct tcc tcc gtt gga aga tac aag acc ttc tcc acc 720 Ile Leu Lys Ile Pro Ser Ser Val Gly Arg Tyr Lys Thr Phe Ser Thr 225 230 235 240 tgt gcc tcc cat ctc att gtg gta act gtt cac tac agt tgt gcc tct 768 Cys Ala Ser His Leu Ile Val Val Thr Val His Tyr Ser Cys Ala Ser 245 250 255 ttc atc tac tta agg ccc aag act aat tac act tca agc caa gac acc 816 Phe Ile Tyr Leu Arg Pro Lys Thr Asn Tyr Thr Ser Ser Gln Asp Thr 260 265 270 cta ata tct gtg tca tac acc atc ctt acc cca ttg ttc aat cca atg 864 Leu Ile Ser Val Ser Tyr Thr Ile Leu Thr Pro Leu Phe Asn Pro Met 275 280 285 att tat agt ctg aga aat aag gaa ttc aaa tca gcc cta cga aga aca 912 Ile Tyr Ser Leu Arg Asn Lys Glu Phe Lys Ser Ala Leu Arg Arg Thr 290 295 300 atc ggc caa act ttc tat cct ctt agt taa 942 Ile Gly Gln Thr Phe Tyr Pro Leu Ser 305 310 <210> 566 <211> 313 <212> PRT <213> Homo sapiens <400> 566 Met Glu Gln Val Asn Lys Thr Val Val Arg Glu Phe Val Val Leu Gly 1 5 10 15 Phe Ser Ser Leu Ala Arg Leu Gln Gln Leu Leu Phe Val Ile Phe Leu 20 25 30 Leu Leu Tyr Leu Phe Thr Leu Gly Thr Asn Ala Ile Ile Ile Ser Thr 35 40 45 Ile Val Leu Asp Arg Ala Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Ile Leu Ser Cys Ser Glu Ile Cys Tyr Thr Phe Val Ile Val Pro Lys 65 70 75 80 Met Leu Val Asp Leu Leu Ser Gln Lys Lys Thr Ile Ser Phe Leu Gly 85 90 95 Cys Ala Ile Gln Met Phe Ser Phe Leu Phe Phe Gly Ser Ser His Ser 100 105 110 Phe Leu Leu Ala Ala Met Gly Tyr Asp Arg Tyr Met Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Ser Val Leu Met Gly His Gly Val Cys Met Gly Leu 130 135 140 Met Ala Ala Ala Cys Ala Cys Gly Phe Thr Val Ser Leu Val Thr Thr 145 150 155 160 Ser Leu Val Phe His Leu Pro Phe His Ser Ser Asn Gln Leu His His 165 170 175 Phe Phe Cys Asp Ile Ser Pro Val Leu Lys Leu Ala Ser Gln His Ser 180 185 190 Gly Phe Ser Gln Leu Val Ile Phe Met Leu Gly Val Phe Ala Leu Val 195 200 205 Ile Pro Leu Leu Leu Ile Leu Val Ser Tyr Ile Arg Ile Ile Ser Ala 210 215 220 Ile Leu Lys Ile Pro Ser Ser Val Gly Arg Tyr Lys Thr Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Ile Val Val Thr Val His Tyr Ser Cys Ala Ser 245 250 255 Phe Ile Tyr Leu Arg Pro Lys Thr Asn Tyr Thr Ser Ser Gln Asp Thr 260 265 270 Leu Ile Ser Val Ser Tyr Thr Ile Leu Thr Pro Leu Phe Asn Pro Met 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Phe Lys Ser Ala Leu Arg Arg Thr 290 295 300 Ile Gly Gln Thr Phe Tyr Pro Leu Ser 305 310 <210> 567 <211> 927 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(927) <400> 567 atg gac aca ggc aac aaa act ctg ccc cag gac ttt ctc tta ctg ggc 48 Met Asp Thr Gly Asn Lys Thr Leu Pro Gln Asp Phe Leu Leu Leu Gly 1 5 10 15 ttt cct ggt tct caa act ctt cag ctc tct ctc ttt atg ctt ttt ctg 96 Phe Pro Gly Ser Gln Thr Leu Gln Leu Ser Leu Phe Met Leu Phe Leu 20 25 30 gtg atg tac atc ctc aca gtt agt ggt aat gtg gct atc ttg atg ttg 144 Val Met Tyr Ile Leu Thr Val Ser Gly Asn Val Ala Ile Leu Met Leu 35 40 45 gtg agc acc tcc cat cag ttg cat acc ccc atg tac ttc ttt ctg agc 192 Val Ser Thr Ser His Gln Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 aac ctc tcc ttc ctg gag att tgg tat acc aca gca gca gtg ccc aaa 240 Asn Leu Ser Phe Leu Glu Ile Trp Tyr Thr Thr Ala Ala Val Pro Lys 65 70 75 80 gca ctg gcc atc cta ctg ggg aga agt cag acc ata tca ttt aca agc 288 Ala Leu Ala Ile Leu Leu Gly Arg Ser Gln Thr Ile Ser Phe Thr Ser 85 90 95 tgt ctt ttg cag atg tac ttt gtt ttc tca tta ggc tgc aca gag tac 336 Cys Leu Leu Gln Met Tyr Phe Val Phe Ser Leu Gly Cys Thr Glu Tyr 100 105 110 ttc ctc ctg gca gcc atg gct tat gac cgc tgt ctt gcc atc tgc tat 384 Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Cys Leu Ala Ile Cys Tyr 115 120 125 cct tta cac tac gga gcc atc atg agt agc ctg ctc tca gcg cag ctg 432 Pro Leu His Tyr Gly Ala Ile Met Ser Ser Leu Leu Ser Ala Gln Leu 130 135 140 gcc ctg ggc tcc tgg gtg tgt ggt ttc gtg gcc att gca gtg ccc aca 480 Ala Leu Gly Ser Trp Val Cys Gly Phe Val Ala Ile Ala Val Pro Thr 145 150 155 160 gcc ctc atc agt ggc ctg tcc ttc tgt ggc ccc cgt gcc atc aac cac 528 Ala Leu Ile Ser Gly Leu Ser Phe Cys Gly Pro Arg Ala Ile Asn His 165 170 175 ttc ttc tgt gac att gca ccc tgg att gcc ctg gcc tgc acc aac aca 576 Phe Phe Cys Asp Ile Ala Pro Trp Ile Ala Leu Ala Cys Thr Asn Thr 180 185 190 cag gca gta gag ctt gtg gcc ttt gtg att gct gtt gtg gtt atc ctg 624 Gln Ala Val Glu Leu Val Ala Phe Val Ile Ala Val Val Val Ile Leu 195 200 205 agt tca tgc ctc atc acc ttt gtc tcc tat gtg tac atc atc agc acc 672 Ser Ser Cys Leu Ile Thr Phe Val Ser Tyr Val Tyr Ile Ile Ser Thr 210 215 220 atc ctc agg atc ccc tct gcc agt ggc cgg agc aaa gcc ttc tcc acg 720 Ile Leu Arg Ile Pro Ser Ala Ser Gly Arg Ser Lys Ala Phe Ser Thr 225 230 235 240 tgc tcc tcg cat ctc acc gtg gtg ctc att tgg tat ggg tcc aca gtt 768 Cys Ser Ser His Leu Thr Val Val Leu Ile Trp Tyr Gly Ser Thr Val 245 250 255 ttc ctt cac gtc cgc acc tct atc aaa gat gcc ttg gat ctg atc aaa 816 Phe Leu His Val Arg Thr Ser Ile Lys Asp Ala Leu Asp Leu Ile Lys 260 265 270 gct gtc cac gtc ctg aac act gtg gtg act cca gtt tta aac ccc ttc 864 Ala Val His Val Leu Asn Thr Val Val Thr Pro Val Leu Asn Pro Phe 275 280 285 atc tat acg ctt cgt aat aag gaa gta aga gag act ctg ctg aag aaa 912 Ile Tyr Thr Leu Arg Asn Lys Glu Val Arg Glu Thr Leu Leu Lys Lys 290 295 300 tgg aag gga aaa taa 927 Trp Lys Gly Lys 305 <210> 568 <211> 308 <212> PRT <213> Homo sapiens <400> 568 Met Asp Thr Gly Asn Lys Thr Leu Pro Gln Asp Phe Leu Leu Leu Gly 1 5 10 15 Phe Pro Gly Ser Gln Thr Leu Gln Leu Ser Leu Phe Met Leu Phe Leu 20 25 30 Val Met Tyr Ile Leu Thr Val Ser Gly Asn Val Ala Ile Leu Met Leu 35 40 45 Val Ser Thr Ser His Gln Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Leu Glu Ile Trp Tyr Thr Thr Ala Ala Val Pro Lys 65 70 75 80 Ala Leu Ala Ile Leu Leu Gly Arg Ser Gln Thr Ile Ser Phe Thr Ser 85 90 95 Cys Leu Leu Gln Met Tyr Phe Val Phe Ser Leu Gly Cys Thr Glu Tyr 100 105 110 Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Cys Leu Ala Ile Cys Tyr 115 120 125 Pro Leu His Tyr Gly Ala Ile Met Ser Ser Leu Leu Ser Ala Gln Leu 130 135 140 Ala Leu Gly Ser Trp Val Cys Gly Phe Val Ala Ile Ala Val Pro Thr 145 150 155 160 Ala Leu Ile Ser Gly Leu Ser Phe Cys Gly Pro Arg Ala Ile Asn His 165 170 175 Phe Phe Cys Asp Ile Ala Pro Trp Ile Ala Leu Ala Cys Thr Asn Thr 180 185 190 Gln Ala Val Glu Leu Val Ala Phe Val Ile Ala Val Val Val Ile Leu 195 200 205 Ser Ser Cys Leu Ile Thr Phe Val Ser Tyr Val Tyr Ile Ile Ser Thr 210 215 220 Ile Leu Arg Ile Pro Ser Ala Ser Gly Arg Ser Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Leu Thr Val Val Leu Ile Trp Tyr Gly Ser Thr Val 245 250 255 Phe Leu His Val Arg Thr Ser Ile Lys Asp Ala Leu Asp Leu Ile Lys 260 265 270 Ala Val His Val Leu Asn Thr Val Val Thr Pro Val Leu Asn Pro Phe 275 280 285 Ile Tyr Thr Leu Arg Asn Lys Glu Val Arg Glu Thr Leu Leu Lys Lys 290 295 300 Trp Lys Gly Lys 305 <210> 569 <211> 1053 <212> DNA <213> Homo sapiens <22 0> <221> CDS <222> (1)..(1053) <400> 569 atg aat agt ttg gga aag ttg gtc tcc atg atc ctc tca gct cat gtg 48 Met Asn Ser Leu Gly Lys Leu Val Ser Met Ile Leu Ser Ala His Val 1 5 10 15 ttc tgt tat tct aaa ttt aat tgt ttt gga tgt acc cat tcc att cct 96 Phe Cys Tyr Ser Lys Phe Asn Cys Phe Gly Cys Thr His Ser Ile Pro 20 25 30 gcc tta ggt gcg gat ccc cct gga ggg atg gga ttg ggc aat gag agt 144 Ala Leu Gly Ala Asp Pro Pro Gly Gly Met Gly Leu Gly Asn Glu Ser 35 40 45 tcc cta atg gat ttc atc ctt cta ggc ttc tca gac cac cct cgt ctg 192 Ser Leu Met Asp Phe Ile Leu Leu Gly Phe Ser Asp His Pro Arg Leu 50 55 60 gag gct gtt ctc ttt gta ttt gtc ctt ttc ttc tac ctc ctg acc ctt 240 Glu Ala Val Leu Phe Val Phe Val Leu Phe Phe Tyr Leu Leu Thr Leu 65 70 75 80 gtg gga aac ttc acc ata atc atc atc tca tat ctg gat ccc cct ctt 288 Val Gly Asn Phe Thr Ile Ile Ile Ile Ser Tyr Leu Asp Pro Pro Leu 85 90 95 cat acc cca atg tac ttt ttt ctc agc aac ctc tct tta ctg gac atc 336 His Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu Ser Leu Leu Asp Ile 100 105 110 tgc ttc act act agc ctt gct cct cag acc tta gtt aac ttg caa aga 384 Cys Phe Thr Thr Ser Leu Ala Pro Gln Thr Leu Val Asn Leu Gln Arg 115 120 125 cca aag aag acg atc act tac ggt ggt tgt gtg gcg caa ctc tat att 432 Pro Lys Lys Thr Ile Thr Tyr Gly Gly Cys Val Ala Gln Leu Tyr Ile 130 135 140 tct ctg gca ctg ggc tcc act gaa tgt atc ctc ttg gct gac atg gcc 480 Ser Leu Ala Leu Gly Ser Thr Glu Cys Ile Leu Leu Ala Asp Met Ala 145 150 155 160 ttg gat cgg tac att gct gtc tgc aaa ccc ctc cac tat gta gtc atc 528 Leu Asp Arg Tyr Ile Ala Val Cys Lys Pro Leu His Tyr Val Val Ile 165 170 175 atg aac cca cgg ctt tgc caa cag ctg gca tct atc tcc tgg ctc agt 576 Met Asn Pro Arg Leu Cys Gln Gln Leu Ala Ser Ile Ser Trp Leu Ser 180 185 190 ggt ttg gct agt tcc cta atc cat gca act ttt acc ttg caa ttg cct 624 Gly Leu Ala Ser Ser Leu Ile His Ala Thr Phe Thr Leu Gln Leu Pro 195 200 205 ctc tgt ggc aac cat agg ctg gac cat ttt att tgc gaa gta cca gct 672 Leu Cys Gly Asn His Arg Leu Asp His Phe Ile Cys Glu Val Pro Ala 210 215 220 ctt ctc aag ttg gct tgt gtg gac acc act gtc aat gaa ttg gtg ctt 720 Leu Leu Lys Leu Ala Cys Val Asp Thr Thr Val Asn Glu Leu Val Leu 225 230 235 240 ttt gtt gtt agt gtt ctg ttt gtt gtc att cca cca gca ctc atc tcc 768 Phe Val Val Ser Val Leu Phe Val Val Ile Pro Pro Ala Leu Ile Ser 245 250 255 atc tcc tat ggc ttc ata act caa gct gtg ctg agg atc aaa tca gta 816 Ile Ser Tyr Gly Phe Ile Thr Gln Ala Val Leu Arg Ile Lys Ser Val 260 265 270 gag gca agg cat aaa gcc ttc agc acc tgc tcc tcc cac ctt aca gtg 864 Glu Ala Arg His Lys Ala Phe Ser Thr Cys Ser Ser His Leu Thr Val 275 280 285 gtg att ata ttc tat ggc acc ata atc tac gtg tac ctg caa cct agt 912 Val Ile Ile Phe Tyr Gly Thr Ile Ile Tyr Val Tyr Leu Gln Pro Ser 290 295 300 gac agc tat gcc cag gac caa ggg aag ttt atc tcc ctc ttc tac acc 960 Asp Ser Tyr Ala Gln Asp Gln Gly Lys Phe Ile Ser Leu Phe Tyr Thr 305 310 315 320 atg gtg acc ccc act tta aat cct atc atc tat act tta agg aac aag 1008 Met Val Thr Pro Thr Leu Asn Pro Ile Ile Tyr Thr Leu Arg Asn Lys 325 330 335 gat atg aaa gag gct ctg agg aaa ctt ctc tcg gga aaa ttg tga 1053 Asp Met Lys Glu Ala Leu Arg Lys Leu Leu Ser Gly Lys Leu 340 345 350 <210> 570 <211> 350 <212> PRT <213> Homo sapiens <400> 570 Met Asn Ser Leu Gly Lys Leu Val Ser Met Ile Leu Ser Ala His Val 1 5 10 15 Phe Cys Tyr Ser Lys Phe Asn Cys Phe Gly Cys Thr His Ser Ile Pro 20 25 30 Ala Leu Gly Ala Asp Pro Pro Gly Gly Met Gly Leu Gly Asn Glu Ser 35 40 45 Ser Leu Met Asp Phe Ile Leu Leu Gly Phe Ser Asp His Pro Arg Leu 50 55 60 Glu Ala Val Leu Phe Val Phe Val Leu Phe Phe Tyr Leu Leu Thr Leu 65 70 75 80 Val Gly Asn Phe Thr Ile Ile Ile Ile Ser Tyr Leu Asp Pro Pro Leu 85 90 95 His Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu Ser Leu Leu Asp Ile 100 105 110 Cys Phe Thr Thr Ser Leu Ala Pro Gln Thr Leu Val Asn Leu Gln Arg 115 120 125 Pro Lys Lys Thr Ile Thr Tyr Gly Gly Cys Val Ala Gln Leu Tyr Ile 130 135 140 Ser Leu Ala Leu Gly Ser Thr Glu Cys Ile Leu Leu Ala Asp Met Ala 145 150 155 160 Leu Asp Arg Tyr Ile Ala Val Cys Lys Pro Leu His Tyr Val Val Ile 165 170 175 Met Asn Pro Arg Leu Cys Gln Gln Leu Ala Ser Ile Ser Trp Leu Ser 180 185 190 Gly Leu Ala Ser Ser Leu Ile His Ala Thr Phe Thr Leu Gln Leu Pro 195 200 205 Leu Cys Gly Asn His Arg Leu Asp His Phe Ile Cys Glu Val Pro Ala 210 215 220 Leu Leu Lys Leu Ala Cys Val Asp Thr Thr Val Asn Glu Leu Val Leu 225 230 235 240 Phe Val Val Ser Val Leu Phe Val Val Ile Pro Pro Ala Leu Ile Ser 245 250 255 Ile Ser Tyr Gly Phe Ile Thr Gln Ala Val Leu Arg Ile Lys Ser Val 260 265 270 Glu Ala Arg His Lys Ala Phe Ser Thr Cys Ser Ser His Leu Thr Val 275 280 285 Val Ile Ile Phe Tyr Gly Thr Ile Ile Tyr Val Tyr Leu Gln Pro Ser 290 295 300 Asp Ser Tyr Ala Gln Asp Gln Gly Lys Phe Ile Ser Leu Phe Tyr Thr 305 310 315 320 Met Val Thr Pro Thr Leu Asn Pro Ile Ile Tyr Thr Leu Arg Asn Lys 325 330 335 Asp Met Lys Glu Ala Leu Arg Lys Leu Leu Ser Gly Lys Leu 340 345 350 <210> 571 <211> 879 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(879) <400> 571 atg agt gta aca gaa aat acg ctc atg atc ctc ctc att cgc agt gac 48 Met Ser Val Thr Glu Asn Thr Leu Met Ile Leu Leu Ile Arg Ser Asp 1 5 10 15 tcc cga ctc cac act cca atg tat ttt ctg ctc agc cat ctc tcc tta 96 Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ser His Leu Ser Leu 20 25 30 atg gat atc ttg cat gtt tcc aac atc gtt ccc aaa atg gtc act aac 144 Met Asp Ile Leu His Val Ser Asn Ile Val Pro Lys Met Val Thr Asn 35 40 45 ttt ctg tca ggc agc aga act att tca ttt gca ggt tgt ggg ttc cag 192 Phe Leu Ser Gly Ser Arg Thr Ile Ser Phe Ala Gly Cys Gly Phe Gln 50 55 60 gta ttt ctg tcc ctc acc ctc ctg ggt ggt gag tgc ctt ctc ctg gct 240 Val Phe Leu Ser Leu Thr Leu Leu Gly Gly Glu Cys Leu Leu Leu Ala 65 70 75 80 gca atg tcc tgt gat cgc tat gtg gct atc tgt cac ccg ctg cgc tat 288 Ala Met Ser Cys Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr 85 90 95 ccg att ctt atg aag gag tat gcc agc gct ctc atg gct gga ggc tcc 336 Pro Ile Leu Met Lys Glu Tyr Ala Ser Ala Leu Met Ala Gly Gly Ser 100 105 110 tgg ctc att ggg gtt ttc aac tcc aca gtc cac aca gct tat gca ctg 384 Trp Leu Ile Gly Val Phe Asn Ser Thr Val His Thr Ala Tyr Ala Leu 115 120 125 cag ttt ccc ttc tgt ggc tct agg gca att gat cac ttc ttc tgt gaa 432 Gln Phe Pro Phe Cys Gly Ser Arg Ala Ile Asp His Phe Phe Cys Glu 130 135 140 gtc cct gcc atg ttg aag ttg tcc tgt gca gac aca aca cgc tat gaa 480 Val Pro Ala Met Leu Lys Leu Ser Cys Ala Asp Thr Thr Arg Tyr Glu 145 150 155 160 cga ggg gtt tgt gta agt gct gtg atc ttc ctg ctg atc cct ttc tcc 528 Arg Gly Val Cys Val Ser Ala Val Ile Phe Leu Leu Ile Pro Phe Ser 165 170 175 ttg atc tct gct tct tat ggc caa att att ctt act gtc ctc cag atg 576 Leu Ile Ser Ala Ser Tyr Gly Gln Ile Ile Leu Thr Val Leu Gln Met 180 185 190 aaa tca tca gag gca agg aaa aag tca ttt tcc act tgt tcc ttc cac 624 Lys Ser Ser Glu Ala Arg Lys Lys Ser Phe Ser Thr Cys Ser Phe His 195 200 205 atg att gtg gtc acg atg tac tat ggg cca ttt att ttt aca tat atg 672 Met Ile Val Val Thr Met Tyr Tyr Gly Pro Phe Ile Phe Thr Tyr Met 210 215 220 aga cct aaa tca tac cac act cca ggc cag gat aag ttc ctg gca ata 720 Arg Pro Lys Ser Tyr His Thr Pro Gly Gln Asp Lys Phe Leu Ala Ile 225 230 235 240 ttc tat acg atc ctc aca ccc aca ctc aac cct ttc atc tac agc ttt 768 Phe Tyr Thr Ile Leu Thr Pro Thr Leu Asn Pro Phe Ile Tyr Ser Phe 245 250 255 agg aat aaa gat gtt ctg gcg gtg atg aaa aat atg ctc aaa agt aac 816 Arg Asn Lys Asp Val Leu Ala Val Met Lys Asn Met Leu Lys Ser Asn 260 265 270 ttt ctg cac aaa aaa atg aat agg aaa att cct gaa tgt gtg ttc tgt 864 Phe Leu His Lys Lys Met Asn Arg Lys Ile Pro Glu Cys Val Phe Cys 275 280 285 cta ttt cta tgt taa 879 Leu Phe Leu Cys 290 <210> 572 <211> 292 <212> PRT <213> Homo sapiens <400> 572 Met Ser Val Thr Glu Asn Thr Leu Met Ile Leu Leu Ile Arg Ser Asp 1 5 10 15 Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ser His Leu Ser Leu 20 25 30 Met Asp Ile Leu His Val Ser Asn Ile Val Pro Lys Met Val Thr Asn 35 40 45 Phe Leu Ser Gly Ser Arg Thr Ile Ser Phe Ala Gly Cys Gly Phe Gln 50 55 60 Val Phe Leu Ser Leu Thr Leu Leu Gly Gly Glu Cys Leu Leu Leu Ala 65 70 75 80 Ala Met Ser Cys Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr 85 90 95 Pro Ile Leu Met Lys Glu Tyr Ala Ser Ala Leu Met Ala Gly Gly Ser 100 105 110 Trp Leu Ile Gly Val Phe Asn Ser Thr Val His Thr Ala Tyr Ala Leu 115 120 125 Gln Phe Pro Phe Cys Gly Ser Arg Ala Ile Asp His Phe Phe Cys Glu 130 135 140 Val Pro Ala Met Leu Lys Leu Ser Cys Ala Asp Thr Thr Arg Tyr Glu 145 150 155 160 Arg Gly Val Cys Val Ser Ala Val Ile Phe Leu Leu Ile Pro Phe Ser 165 170 175 Leu Ile Ser Ala Ser Tyr Gly Gln Ile Ile Leu Thr Val Leu Gln Met 180 185 190 Lys Ser Ser Glu Ala Arg Lys Lys Ser Phe Ser Thr Cys Ser Phe His 195 200 205 Met Ile Val Val Thr Met Tyr Tyr Gly Pro Phe Ile Phe Thr Tyr Met 210 215 220 Arg Pro Lys Ser Tyr His Thr Pro Gly Gln Asp Lys Phe Leu Ala Ile 225 230 235 240 Phe Tyr Thr Ile Leu Thr Pro Thr Leu Asn Pro Phe Ile Tyr Ser Phe 245 250 255 Arg Asn Lys Asp Val Leu Ala Val Met Lys Asn Met Leu Lys Ser Asn 260 265 270 Phe Leu His Lys Lys Met Asn Arg Lys Ile Pro Glu Cys Val Phe Cys 275 280 285 Leu Phe Leu Cys 290 <210> 573 <211> 963 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(963) <400> 573 atg att ctc ctg att cac tgg gac cac cgg ttc cac acg ccc atg tac 48 Met Ile Leu Leu Ile His Trp Asp His Arg Phe His Thr Pro Met Tyr 1 5 10 15 ttc ctc ctg agc caa ctt tcc ctc atg gac gtg atg ctg gtt tcc acc 96 Phe Leu Leu Ser Gln Leu Ser Leu Met Asp Val Met Leu Val Ser Thr 20 25 30 act gtg ccc aaa atg gcg gct gac tac ttg acc gga agt aag gcc atc 144 Thr Val Pro Lys Met Ala Ala Asp Tyr Leu Thr Gly Ser Lys Ala Ile 35 40 45 tcc cgc gct ggc tgt ggt gcg cag atc ttc ttc ctc ccc aca ctg ggt 192 Ser Arg Ala Gly Cys Gly Ala Gln Ile Phe Phe Leu Pro Thr Leu Gly 50 55 60 ggt gga gag tgc ttc ctc tta gca gcc atg gcc tat gac cgc tat gcg 240 Gly Gly Glu Cys Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Ala 65 70 75 80 gct gtc tgc cac cca ctc cga tat ccc act ctc atg agc tgg cag ctg 288 Ala Val Cys His Pro Leu Arg Tyr Pro Thr Leu Met Ser Trp Gln Leu 85 90 95 tgc ctg agg atg aac ctg tcg tgt tgg ctc ctg ggt gca gct gac ggg 336 Cys Leu Arg Met Asn Leu Ser Cys Trp Leu Leu Gly Ala Ala Asp Gly 100 105 110 ctc ctg cag gct gtt gct acc ctg agc ttc cca tat tgc ggt gca cac 384 Leu Leu Gln Ala Val Ala Thr Leu Ser Phe Pro Tyr Cys Gly Ala His 115 120 125 gag atc gat cac ttc ttc tgc gag acc ccc gtg ctg gtg cgt ttg gct 432 Glu Ile Asp His Phe Phe Cys Glu Thr Pro Val Leu Val Arg Leu Ala 130 135 140 tgt gct gac act tca gtc ttc gaa aac gcc atg tac atc tgc tgt gtg 480 Cys Ala Asp Thr Ser Val Phe Glu Asn Ala Met Tyr Ile Cys Cys Val 145 150 155 160 tta atg ctc ctg gtc ccc ttt tcc ctc atc ctg tcc tcc tat ggt ctc 528 Leu Met Leu Leu Val Pro Phe Ser Leu Ile Leu Ser Ser Tyr Gly Leu 165 170 175 atc ctc gct gct gtt ctg cac atg cgc tct aca gaa gcc cgc aag aag 576 Ile Leu Ala Ala Val Leu His Met Arg Ser Thr Glu Ala Arg Lys Lys 180 185 190 gcc ttt gcc acc tgc tct tca cat gtg gct gtg gtg gga ctc ttt tat 624 Ala Phe Ala Thr Cys Ser Ser His Val Ala Val Val Gly Leu Phe Tyr 195 200 205 gga gct gcc att ttt acc tat atg aga ccc aaa tcc cac agg tcc act 672 Gly Ala Ala Ile Phe Thr Tyr Met Arg Pro Lys Ser His Arg Ser Thr 210 215 220 aac cac gac aag gtt gtg tca gcc ttc tat act atg ttc acc cct tta 720 Asn His Asp Lys Val Val Ser Ala Phe Tyr Thr Met Phe Thr Pro Leu 225 230 235 240 cta aac ccc ctc atc tac agt gtg aan nnn nnn nnn nnn nnn nnn nnn 768 Leu Asn Pro Leu Ile Tyr Ser Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 245 250 255 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 816 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 260 265 270 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn ttc tat act atg ttc acc 864 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Phe Tyr Thr Met Phe Thr 275 280 285 cct ttt cta aac ccc ctc atc tac agt gtc cag aac agt gag gtg aag 912 Pro Phe Leu Asn Pro Leu Ile Tyr Ser Val Gln Asn Ser Glu Val Lys 290 295 300 gga gcc ctg aca agg tgt atg ggt cgg tgt gtg gcc tta agt cgt gaa 960 Gly Ala Leu Thr Arg Cys Met Gly Arg Cys Val Ala Leu Ser Arg Glu 305 310 315 320 taa 963 <210> 574 <211> 320 <212> PRT <213> Homo sapiens <400> 574 Met Ile Leu Leu Ile His Trp Asp His Arg Phe His Thr Pro Met Tyr 1 5 10 15 Phe Leu Leu Ser Gln Leu Ser Leu Met Asp Val Met Leu Val Ser Thr 20 25 30 Thr Val Pro Lys Met Ala Ala Asp Tyr Leu Thr Gly Ser Lys Ala Ile 35 40 45 Ser Arg Ala Gly Cys Gly Ala Gln Ile Phe Phe Leu Pro Thr Leu Gly 50 55 60 Gly Gly Glu Cys Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Ala 65 70 75 80 Ala Val Cys His Pro Leu Arg Tyr Pro Thr Leu Met Ser Trp Gln Leu 85 90 95 Cys Leu Arg Met Asn Leu Ser Cys Trp Leu Leu Gly Ala Ala Asp Gly 100 105 110 Leu Leu Gln Ala Val Ala Thr Leu Ser Phe Pro Tyr Cys Gly Ala His 115 120 125 Glu Ile Asp His Phe Phe Cys Glu Thr Pro Val Leu Val Arg Leu Ala 130 135 140 Cys Ala Asp Thr Ser Val Phe Glu Asn Ala Met Tyr Ile Cys Cys Val 145 150 155 160 Leu Met Leu Leu Val Pro Phe Ser Leu Ile Leu Ser Ser Tyr Gly Leu 165 170 175 Ile Leu Ala Ala Val Leu His Met Arg Ser Thr Glu Ala Arg Lys Lys 180 185 190 Ala Phe Ala Thr Cys Ser Ser His Val Ala Val Val Gly Leu Phe Tyr 195 200 205 Gly Ala Ala Ile Phe Thr Tyr Met Arg Pro Lys Ser His Arg Ser Thr 210 215 220 Asn His Asp Lys Val Val Ser Ala Phe Tyr Thr Met Phe Thr Pro Leu 225 230 235 240 Leu Asn Pro Leu Ile Tyr Ser Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 245 250 255 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 260 265 270 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Phe Tyr Thr Met Phe Thr 275 280 285 Pro Phe Leu Asn Pro Leu Ile Tyr Ser Val Gln Asn Ser Glu Val Lys 290 295 300 Gly Ala Leu Thr Arg Cys Met Gly Arg Cys Val Ala Leu Ser Arg Glu 305 310 315 320 <210> 575 <211> 939 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(939) <400> 575 atg gaa aat tac aat caa aca tca act gat ttc atc tta ttg ggg ctg 48 Met Glu Asn Tyr Asn Gln Thr Ser Thr Asp Phe Ile Leu Leu Gly Leu 1 5 10 15 ttt cca cca tca ata att gac ctt ttc ttc ttc att ctc att gtt ttc 96 Phe Pro Pro Ser Ile Ile Asp Leu Phe Phe Phe Ile Leu Ile Val Phe 20 25 30 att ttc ctg atg gct cta att gga aac ctg tcc atg att ctt ctc atc 144 Ile Phe Leu Met Ala Leu Ile Gly Asn Leu Ser Met Ile Leu Leu Ile 35 40 45 ttc ttg gac acc cat ctc cac aca ccc atg tat ttc cta ctg agt cag 192 Phe Leu Asp Thr His Leu His Thr Pro Met Tyr Phe Leu Leu Ser Gln 50 55 60 ctc tcc ctc att gac cta aat tac atc tcc acc att gtt cct aag atg 240 Leu Ser Leu Ile Asp Leu Asn Tyr Ile Ser Thr Ile Val Pro Lys Met 65 70 75 80 gca tct gat ttt ctg cat gga aac aag tct atc tcc ttc act ggg tgt 288 Ala Ser Asp Phe Leu His Gly Asn Lys Ser Ile Ser Phe Thr Gly Cys 85 90 95 ggg att cag agt ttc ttc ttc ttg gca tta gga ggt gca gaa gca cta 336 Gly Ile Gln Ser Phe Phe Phe Leu Ala Leu Gly Gly Ala Glu Ala Leu 100 105 110 ctt ttg gca tct atg gcc tat gat cgt tac att gct att tgc ttt cct 384 Leu Leu Ala Ser Met Ala Tyr Asp Arg Tyr Ile Ala Ile Cys Phe Pro 115 120 125 ctc cac tat ctc atc cgc atg agc aaa aga gtg tgt gtg ctg atg ata 432 Leu His Tyr Leu Ile Arg Met Ser Lys Arg Val Cys Val Leu Met Ile 130 135 140 aca ggg tct tgg atc ata ggc tcg atc aat gct tgt gct cac act gta 480 Thr Gly Ser Trp Ile Ile Gly Ser Ile Asn Ala Cys Ala His Thr Val 145 150 155 160 tat gta ctc cat att cct tat tgc cga tcc agg gcc atc aat cat ttc 528 Tyr Val Leu His Ile Pro Tyr Cys Arg Ser Arg Ala Ile Asn His Phe 165 170 175 ttc tgt gat gtc cca gca atg gtg act ctg gcc tgc atg gac acc tgg 576 Phe Cys Asp Val Pro Ala Met Val Thr Leu Ala Cys Met Asp Thr Trp 180 185 190 gtc tat gag ggc aca gtg ttt ttg agt gcc acc atc ttt ctc gtg ttt 624 Val Tyr Glu Gly Thr Val Phe Leu Ser Ala Thr Ile Phe Leu Val Phe 195 200 205 ccc ttc att ggt att tca tgt tcc tat ggc cag gtt ctc ttt gct gtc 672 Pro Phe Ile Gly Ile Ser Cys Ser Tyr Gly Gln Val Leu Phe Ala Val 210 215 220 tac cac atg aaa tct gca gaa ggg agg aag aaa gcc tat ttg acc tgc 720 Tyr His Met Lys Ser Ala Glu Gly Arg Lys Lys Ala Tyr Leu Thr Cys 225 230 235 240 agc acc cac ctc act gta gta act ttc tac tat gca cct ttt gtc tac 768 Ser Thr His Leu Thr Val Val Thr Phe Tyr Tyr Ala Pro Phe Val Tyr 245 250 255 act tat cta cgt cca aga tcc ctg cga tct cca aca gag gac aag gtt 816 Thr Tyr Leu Arg Pro Arg Ser Leu Arg Ser Pro Thr Glu Asp Lys Val 260 265 270 ctg gct gtc ttc tac acc atc ctc acc cca atg ctc aac ccc atc atc 864 Leu Ala Val Phe Tyr Thr Ile Leu Thr Pro Met Leu Asn Pro Ile Ile 275 280 285 tat agc ctg agg aac aag gag gtg atg ggg gcc ctg aca cga gtg agt 912 Tyr Ser Leu Arg Asn Lys Glu Val Met Gly Ala Leu Thr Arg Val Ser 290 295 300 cag aga atc tgc tct gtg aaa atg tag 939 Gln Arg Ile Cys Ser Val Lys Met 305 310 <210> 576 <211> 312 <212> PRT <213> Homo sapiens <400> 576 Met Glu Asn Tyr Asn Gln Thr Ser Thr Asp Phe Ile Leu Leu Gly Leu 1 5 10 15 Phe Pro Pro Ser Ile Ile Asp Leu Phe Phe Phe Ile Leu Ile Val Phe 20 25 30 Ile Phe Leu Met Ala Leu Ile Gly Asn Leu Ser Met Ile Leu Leu Ile 35 40 45 Phe Leu Asp Thr His Leu His Thr Pro Met Tyr Phe Leu Leu Ser Gln 50 55 60 Leu Ser Leu Ile Asp Leu Asn Tyr Ile Ser Thr Ile Val Pro Lys Met 65 70 75 80 Ala Ser Asp Phe Leu His Gly Asn Lys Ser Ile Ser Phe Thr Gly Cys 85 90 95 Gly Ile Gln Ser Phe Phe Phe Leu Ala Leu Gly Gly Ala Glu Ala Leu 100 105 110 Leu Leu Ala Ser Met Ala Tyr Asp Arg Tyr Ile Ala Ile Cys Phe Pro 115 120 125 Leu His Tyr Leu Ile Arg Met Ser Lys Arg Val Cys Val Leu Met Ile 130 135 140 Thr Gly Ser Trp Ile Ile Gly Ser Ile Asn Ala Cys Ala His Thr Val 145 150 155 160 Tyr Val Leu His Ile Pro Tyr Cys Arg Ser Arg Ala Ile Asn His Phe 165 170 175 Phe Cys Asp Val Pro Ala Met Val Thr Leu Ala Cys Met Asp Thr Trp 180 185 190 Val Tyr Glu Gly Thr Val Phe Leu Ser Ala Thr Ile Phe Leu Val Phe 195 200 205 Pro Phe Ile Gly Ile Ser Cys Ser Tyr Gly Gln Val Leu Phe Ala Val 210 215 220 Tyr His Met Lys Ser Ala Glu Gly Arg Lys Lys Ala Tyr Leu Thr Cys 225 230 235 240 Ser Thr His Leu Thr Val Val Thr Phe Tyr Tyr Ala Pro Phe Val Tyr 245 250 255 Thr Tyr Leu Arg Pro Arg Ser Leu Arg Ser Pro Thr Glu Asp Lys Val 260 265 270 Leu Ala Val Phe Tyr Thr Ile Leu Thr Pro Met Leu Asn Pro Ile Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Glu Val Met Gly Ala Leu Thr Arg Val Ser 290 295 300 Gln Arg Ile Cys Ser Val Lys Met 305 310 <210> 577 <211> 951 <212> DNA <213> Homo sapiens <2 20> <221> CDS <222> (1)..(951) <400> 577 atg gag gct gcc aat gag tct tca gag gga atc tca ttc gtt tta ttg 48 Met Glu Ala Ala Asn Glu Ser Ser Glu Gly Ile Ser Phe Val Leu Leu 1 5 10 15 gga ctg aca aca agt cct gga cag cag cgg cct ctc ttt gtg ctg ttc 96 Gly Leu Thr Thr Ser Pro Gly Gln Gln Arg Pro Leu Phe Val Leu Phe 20 25 30 ttg ctc ttg tat gtg gcc agc ctc ctg ggt aat gga ctc att gtg gct 144 Leu Leu Leu Tyr Val Ala Ser Leu Leu Gly Asn Gly Leu Ile Val Ala 35 40 45 gcc atc cag gcc agt cca gcc ctt cat gca ccc atg tac ttc ctg ctg 192 Ala Ile Gln Ala Ser Pro Ala Leu His Ala Pro Met Tyr Phe Leu Leu 50 55 60 gcc cac ctg tcc ttt gct gac ctc tgt ttc gcc tcc gtc act gtg ccc 240 Ala His Leu Ser Phe Ala Asp Leu Cys Phe Ala Ser Val Thr Val Pro 65 70 75 80 aag atg ttg gcc aac ttg ttg gcc cat gac cac tcc atc tcg ctg gct 288 Lys Met Leu Ala Asn Leu Leu Ala His Asp His Ser Ile Ser Leu Ala 85 90 95 ggc tgc ctg acc caa atg tac ttc ttc ttt gcc ctg ggg gta act gat 336 Gly Cys Leu Thr Gln Met Tyr Phe Phe Phe Ala Leu Gly Val Thr Asp 100 105 110 agc tgt ctt ctg gcg gcc atg gcc tat gac tgc tac gtg gcc atc cgg 384 Ser Cys Leu Leu Ala Ala Met Ala Tyr Asp Cys Tyr Val Ala Ile Arg 115 120 125 cac ccc ctc ccc tat gcc acg agg atg tcc cgg gcc atg tgc gca gcc 432 His Pro Leu Pro Tyr Ala Thr Arg Met Ser Arg Ala Met Cys Ala Ala 130 135 140 ctg gtg gga atg gca tgg ctg gtg tcc cac gtc cac tcc ctc ctg tat 480 Leu Val Gly Met Ala Trp Leu Val Ser His Val His Ser Leu Leu Tyr 145 150 155 160 atc ctg ctc atg gct cgc ttg tcc ttc tgt gct tcc cac caa gtg ccc 528 Ile Leu Leu Met Ala Arg Leu Ser Phe Cys Ala Ser His Gln Val Pro 165 170 175 cac ttc ttc tgt gac cac cag cct ctc tta agg ctc tcg tgc tct gac 576 His Phe Phe Cys Asp His Gln Pro Leu Leu Arg Leu Ser Cys Ser Asp 180 185 190 acc cac cac atc cag ctg ctc atc ttc acc gag ggc gcc gca gtg gtg 624 Thr His His Ile Gln Leu Leu Ile Phe Thr Glu Gly Ala Ala Val Val 195 200 205 gtc act ccc ttc ctg ctc atc ctc gcc tcc tat ggg gcc atc gca gct 672 Val Thr Pro Phe Leu Leu Ile Leu Ala Ser Tyr Gly Ala Ile Ala Ala 210 215 220 gcc gtg ctc cag ctg ccc tca gcc tct ggg agg ctc cgg gct gtg tcc 720 Ala Val Leu Gln Leu Pro Ser Ala Ser Gly Arg Leu Arg Ala Val Ser 225 230 235 240 acc tgt ggc tcc cac ctg gct gtg gtg agc ctc ttc tat ggg aca gtc 768 Thr Cys Gly Ser His Leu Ala Val Val Ser Leu Phe Tyr Gly Thr Val 245 250 255 att gca gtc tac ttc cag gcc aca tcc cga cgc gag gca gag tgg ggc 816 Ile Ala Val Tyr Phe Gln Ala Thr Ser Arg Arg Glu Ala Glu Trp Gly 260 265 270 cgt gtg gcc act gtc atg tac act gta gtc acc ccc atg ctg aac ccc 864 Arg Val Ala Thr Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro 275 280 285 atc atc tac agc ctc tgg aat cgc gat gta cag ggg gca ctc cga gcc 912 Ile Ile Tyr Ser Leu Trp Asn Arg Asp Val Gln Gly Ala Leu Arg Ala 290 295 300 ctt ctc att ggg cga agg atc tca gct agt gac tcc tga 951 Leu Leu Ile Gly Arg Arg Ile Ser Ala Ser Asp Ser 305 310 315 <210> 578 <211> 316 <212> PRT <213> Homo sapiens <400> 578 Met Glu Ala Ala Asn Glu Ser Ser Glu Gly Ile Ser Phe Val Leu Leu 1 5 10 15 Gly Leu Thr Thr Ser Pro Gly Gln Gln Arg Pro Leu Phe Val Leu Phe 20 25 30 Leu Leu Leu Tyr Val Ala Ser Leu Leu Gly Asn Gly Leu Ile Val Ala 35 40 45 Ala Ile Gln Ala Ser Pro Ala Leu His Ala Pro Met Tyr Phe Leu Leu 50 55 60 Ala His Leu Ser Phe Ala Asp Leu Cys Phe Ala Ser Val Thr Val Pro 65 70 75 80 Lys Met Leu Ala Asn Leu Leu Ala His Asp His Ser Ile Ser Leu Ala 85 90 95 Gly Cys Leu Thr Gln Met Tyr Phe Phe Phe Ala Leu Gly Val Thr Asp 100 105 110 Ser Cys Leu Leu Ala Ala Met Ala Tyr Asp Cys Tyr Val Ala Ile Arg 115 120 125 His Pro Leu Pro Tyr Ala Thr Arg Met Ser Arg Ala Met Cys Ala Ala 130 135 140 Leu Val Gly Met Ala Trp Leu Val Ser His Val His Ser Leu Leu Tyr 145 150 155 160 Ile Leu Leu Met Ala Arg Leu Ser Phe Cys Ala Ser His Gln Val Pro 165 170 175 His Phe Phe Cys Asp His Gln Pro Leu Leu Arg Leu Ser Cys Ser Asp 180 185 190 Thr His His Ile Gln Leu Leu Ile Phe Thr Glu Gly Ala Ala Val Val 195 200 205 Val Thr Pro Phe Leu Leu Ile Leu Ala Ser Tyr Gly Ala Ile Ala Ala 210 215 220 Ala Val Leu Gln Leu Pro Ser Ala Ser Gly Arg Leu Arg Ala Val Ser 225 230 235 240 Thr Cys Gly Ser His Leu Ala Val Val Ser Leu Phe Tyr Gly Thr Val 245 250 255 Ile Ala Val Tyr Phe Gln Ala Thr Ser Arg Arg Glu Ala Glu Trp Gly 260 265 270 Arg Val Ala Thr Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro 275 280 285 Ile Ile Tyr Ser Leu Trp Asn Arg Asp Val Gln Gly Ala Leu Arg Ala 290 295 300 Leu Leu Ile Gly Arg Arg Ile Ser Ala Ser Asp Ser 305 310 315 <210> 579 <211> 1026 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1026) <400> 579 atg gcc ttg cca ttg ctc tta tct ccc tcc tgc ttt gcc tct tct cag 48 Met Ala Leu Pro Leu Leu Leu Ser Pro Ser Cys Phe Ala Ser Ser Gln 1 5 10 15 tct ctg tcc agt agg atg aac tca gag aac ctc acc cgg gcc gcg gtt 96 Ser Leu Ser Ser Arg Met Asn Ser Glu Asn Leu Thr Arg Ala Ala Val 20 25 30 gcc cct gct gaa ttc gtc ctc ctg ggc atc aca aat cgc tgg gac ctg 144 Ala Pro Ala Glu Phe Val Leu Leu Gly Ile Thr Asn Arg Trp Asp Leu 35 40 45 cgt gtg gcc ctc ttc ctg acc tgc ctg cct gtc tac ctg gtg agc ctg 192 Arg Val Ala Leu Phe Leu Thr Cys Leu Pro Val Tyr Leu Val Ser Leu 50 55 60 ctg gga aac atg ggc atg gcg ctg ctg atc cgc atg gat gcc cgg ctc 240 Leu Gly Asn Met Gly Met Ala Leu Leu Ile Arg Met Asp Ala Arg Leu 65 70 75 80 cac aca cct atg tac ttc ttc ctg gcc aac ctc tcc ctg ctg gat gcc 288 His Thr Pro Met Tyr Phe Phe Leu Ala Asn Leu Ser Leu Leu Asp Ala 85 90 95 tgc tat tcc tcc gcc atc ggc ccc aag atg cta gtg gac ctg ctg ctg 336 Cys Tyr Ser Ser Ala Ile Gly Pro Lys Met Leu Val Asp Leu Leu Leu 100 105 110 ccc cga gcc acc atc cct tac aca gcc tgt gcc ctc cag atg ttt gtc 384 Pro Arg Ala Thr Ile Pro Tyr Thr Ala Cys Ala Leu Gln Met Phe Val 115 120 125 ttt gca ggt ctg gct gat act gag tgt tgc ttg ctg gca gcc atg gcc 432 Phe Ala Gly Leu Ala Asp Thr Glu Cys Cys Leu Leu Ala Ala Met Ala 130 135 140 tat gac cgc tac gtg gcc atc aga aac cca ctt ctc tat aca aca gct 480 Tyr Asp Arg Tyr Val Ala Ile Arg Asn Pro Leu Leu Tyr Thr Thr Ala 145 150 155 160 atg tcg cag cgt cta tgc ctg gcc ttg ctg gga gca tca ggc ctg ggt 528 Met Ser Gln Arg Leu Cys Leu Ala Leu Leu Gly Ala Ser Gly Leu Gly 165 170 175 ggg gca gtg agt gcc ttt gtt cac aca acc ctc acc ttc cgc ctg agc 576 Gly Ala Val Ser Ala Phe Val His Thr Thr Leu Thr Phe Arg Leu Ser 180 185 190 ttc tgc cgc tcc cgg aag atc aat agc ttc ttc tgc gat atc cct cca 624 Phe Cys Arg Ser Arg Lys Ile Asn Ser Phe Phe Cys Asp Ile Pro Pro 195 200 205 ctg ctg gcc atc tcg tgc agt gac acc agt ctc aat gaa ctc ctt ctc 672 Leu Leu Ala Ile Ser Cys Ser Asp Thr Ser Leu Asn Glu Leu Leu Leu 210 215 220 ttc gcc atc tgt ggc ttc atc cag aca gcc acg gtg tta gct atc acg 720 Phe Ala Ile Cys Gly Phe Ile Gln Thr Ala Thr Val Leu Ala Ile Thr 225 230 235 240 gtg tct tat ggc ttc atc gct ggg gct gtg atc cac atg cgc tcg gtc 768 Val Ser Tyr Gly Phe Ile Ala Gly Ala Val Ile His Met Arg Ser Val 245 250 255 gag ggc agt cgg cga gca gcc tcc acc ggt ggt tcc cac ctc aca gcc 816 Glu Gly Ser Arg Arg Ala Ala Ser Thr Gly Gly Ser His Leu Thr Ala 260 265 270 gtg gcc atg atg tac ggg aca ctc att ttc atg tac ctg cgc ccc agc 864 Val Ala Met Met Tyr Gly Thr Leu Ile Phe Met Tyr Leu Arg Pro Ser 275 280 285 tcc agc tat gcc ctg gac act gac aag atg gcc tct gtg ttc tat acc 912 Ser Ser Tyr Ala Leu Asp Thr Asp Lys Met Ala Ser Val Phe Tyr Thr 290 295 300 ctg gtc atc ccg tct ctc aac cca ctc atc tac agc ctc cgc aat aag 960 Leu Val Ile Pro Ser Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys 305 310 315 320 gag gtc aag gag gcc ctc agg cag acc tgg agc cga ttc cac tgt cca 1008 Glu Val Lys Glu Ala Leu Arg Gln Thr Trp Ser Arg Phe His Cys Pro 325 330 335 ggg cag ggg tcc cag tga 1026 Gly Gln Gly Ser Gln 340 <210> 580 <211> 341 <21 2> PRT <213> Homo sapiens <400> 580 Met Ala Leu Pro Leu Leu Leu Ser Pro Ser Cys Phe Ala Ser Ser Gln 1 5 10 15 Ser Leu Ser Ser Arg Met Asn Ser Glu Asn Leu Thr Arg Ala Ala Val 20 25 30 Ala Pro Ala Glu Phe Val Leu Leu Gly Ile Thr Asn Arg Trp Asp Leu 35 40 45 Arg Val Ala Leu Phe Leu Thr Cys Leu Pro Val Tyr Leu Val Ser Leu 50 55 60 Leu Gly Asn Met Gly Met Ala Leu Leu Ile Arg Met Asp Ala Arg Leu 65 70 75 80 His Thr Pro Met Tyr Phe Phe Leu Ala Asn Leu Ser Leu Leu Asp Ala 85 90 95 Cys Tyr Ser Ser Ala Ile Gly Pro Lys Met Leu Val Asp Leu Leu Leu 100 105 110 Pro Arg Ala Thr Ile Pro Tyr Thr Ala Cys Ala Leu Gln Met Phe Val 115 120 125 Phe Ala Gly Leu Ala Asp Thr Glu Cys Cys Leu Leu Ala Ala Met Ala 130 135 140 Tyr Asp Arg Tyr Val Ala Ile Arg Asn Pro Leu Leu Tyr Thr Thr Ala 145 150 155 160 Met Ser Gln Arg Leu Cys Leu Ala Leu Leu Gly Ala Ser Gly Leu Gly 165 170 175 Gly Ala Val Ser Ala Phe Val His Thr Thr Leu Thr Phe Arg Leu Ser 180 185 190 Phe Cys Arg Ser Arg Lys Ile Asn Ser Phe Phe Cys Asp Ile Pro Pro 195 200 205 Leu Leu Ala Ile Ser Cys Ser Asp Thr Ser Leu Asn Glu Leu Leu Leu 210 215 220 Phe Ala Ile Cys Gly Phe Ile Gln Thr Ala Thr Val Leu Ala Ile Thr 225 230 235 240 Val Ser Tyr Gly Phe Ile Ala Gly Ala Val Ile His Met Arg Ser Val 245 250 255 Glu Gly Ser Arg Arg Ala Ala Ser Thr Gly Gly Ser His Leu Thr Ala 260 265 270 Val Ala Met Met Tyr Gly Thr Leu Ile Phe Met Tyr Leu Arg Pro Ser 275 280 285 Ser Ser Tyr Ala Leu Asp Thr Asp Lys Met Ala Ser Val Phe Tyr Thr 290 295 300 Leu Val Ile Pro Ser Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys 305 310 315 320 Glu Val Lys Glu Ala Leu Arg Gln Thr Trp Ser Arg Phe His Cys Pro 325 330 335 Gly Gln Gly Ser Gln 340 <210> 581 <211> 969 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(969) <400> 581 atg agc cct gag aac cag agc agc gtg tcc gag ttc ctc ctc ctg ggc 48 Met Ser Pro Glu Asn Gln Ser Ser Val Ser Glu Phe Leu Leu Leu Gly 1 5 10 15 ctc ccc atc cgg cca gag cag cag gcc gtg ttc ttc gcc ctg ttc ctg 96 Leu Pro Ile Arg Pro Glu Gln Gln Ala Val Phe Phe Ala Leu Phe Leu 20 25 30 ggc atg tac ctg acc acg gtg ctg ggg aac ctg ctc atc atg ctg ctc 144 Gly Met Tyr Leu Thr Thr Val Leu Gly Asn Leu Leu Ile Met Leu Leu 35 40 45 atc cag cta gac tct cac ctt cac acc ccc atg tac ttc ttc ctt agc 192 Ile Gln Leu Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 cac ttg gcc ctc act gac atc tcc ttt tca tct gtc act gtc cct aag 240 His Leu Ala Leu Thr Asp Ile Ser Phe Ser Ser Val Thr Val Pro Lys 65 70 75 80 atg ctg atg aac atg cag act cag cac cta gcc gtc ttt tac aag gga 288 Met Leu Met Asn Met Gln Thr Gln His Leu Ala Val Phe Tyr Lys Gly 85 90 95 tgc att tca cag aca tat ttt ttc ata ttt ttt gct gac tta gac agt 336 Cys Ile Ser Gln Thr Tyr Phe Phe Ile Phe Phe Ala Asp Leu Asp Ser 100 105 110 ttc ctt atc act tca atg gca tat gac agg tat gtg gcc atc tgt cat 384 Phe Leu Ile Thr Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 cct cta cat tat gcc acc atc atg act cag agc cag tgt gtc atg ctg 432 Pro Leu His Tyr Ala Thr Ile Met Thr Gln Ser Gln Cys Val Met Leu 130 135 140 gtg gct ggg tcc tgg gtc atc gct tgt gcg tgt gct ctt ttg cat acc 480 Val Ala Gly Ser Trp Val Ile Ala Cys Ala Cys Ala Leu Leu His Thr 145 150 155 160 ctc ctc ctg gcc cag ctt tcc ttc tgt gct gac cac atc atc cct cac 528 Leu Leu Leu Ala Gln Leu Ser Phe Cys Ala Asp His Ile Ile Pro His 165 170 175 tac ttc tgt gac ctt ggt gcc ctg ctc aag ttg tcc tgc tca gac acc 576 Tyr Phe Cys Asp Leu Gly Ala Leu Leu Lys Leu Ser Cys Ser Asp Thr 180 185 190 tcc ctc aat cag tta gca atc ttt aca gca gca ttg aca gcc att atg 624 Ser Leu Asn Gln Leu Ala Ile Phe Thr Ala Ala Leu Thr Ala Ile Met 195 200 205 ctt cca ttc ctg tgc atc ctg gtt tct tat ggt cac att ggg gtc acc 672 Leu Pro Phe Leu Cys Ile Leu Val Ser Tyr Gly His Ile Gly Val Thr 210 215 220 atc ctc cag att ccc tct acc aag ggc ata tgc aaa gcc ttg tcc act 720 Ile Leu Gln Ile Pro Ser Thr Lys Gly Ile Cys Lys Ala Leu Ser Thr 225 230 235 240 tgt gga tcc cac ctc tca gtg gtg act atc tat tat cgg aca att att 768 Cy s Gly Ser His Leu Ser Val Val Thr Ile Tyr Tyr Arg Thr Ile Ile 245 250 255 ggt ctc tat ttt ctt ccc cca tcc agc aac acc aat gac aag aac ata 816 Gly Leu Tyr Phe Leu Pro Pro Ser Ser Asn Thr Asn Asp Lys Asn Ile 260 265 270 att gct tca gtg ata tac aca gca gtc act ccc atg ttg aac cca ttc 864 Ile Ala Ser Val Ile Tyr Thr Ala Val Thr Pro Met Leu Asn Pro Phe 275 280 285 att tac agt ctg aga aat aaa gac att aag gga gcc cta aga aaa ctc 912 Ile Tyr Ser Leu Arg Asn Lys Asp Ile Lys Gly Ala Leu Arg Lys Leu 290 295 300 ttg agt agg tca ggc gca gtg gct cat gcc tgt aat ctc aac act ttg 960 Leu Ser Arg Ser Gly Ala Val Ala His Ala Cys Asn Leu Asn Thr Leu 305 310 315 320 gga ggc tga 969 Gly Gly <2 10> 582 <211> 322 <212> PRT <213> Homo sapiens <400> 582 Met Ser Pro Glu Asn Gln Ser Ser Val Ser Glu Phe Leu Leu Leu Gly 1 5 10 15 Leu Pro Ile Arg Pro Glu Gln Gln Ala Val Phe Phe Ala Leu Phe Leu 20 25 30 Gly Met Tyr Leu Thr Thr Val Leu Gly Asn Leu Leu Ile Met Leu Leu 35 40 45 Ile Gln Leu Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 His Leu Ala Leu Thr Asp Ile Ser Phe Ser Ser Val Thr Val Pro Lys 65 70 75 80 Met Leu Met Asn Met Gln Thr Gln His Leu Ala Val Phe Tyr Lys Gly 85 90 95 Cys Ile Ser Gln Thr Tyr Phe Phe Ile Phe Phe Ala Asp Leu Asp Ser 100 105 110 Phe Leu Ile Thr Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu His Tyr Ala Thr Ile Met Thr Gln Ser Gln Cys Val Met Leu 130 135 140 Val Ala Gly Ser Trp Val Ile Ala Cys Ala Cys Ala Leu Leu His Thr 145 150 155 160 Leu Leu Leu Ala Gln Leu Ser Phe Cys Ala Asp His Ile Ile Pro His 165 170 175 Tyr Phe Cys Asp Leu Gly Ala Leu Leu Lys Leu Ser Cys Ser Asp Thr 180 185 190 Ser Leu Asn Gln Leu Ala Ile Phe Thr Ala Ala Leu Thr Ala Ile Met 195 200 205 Leu Pro Phe Leu Cys Ile Leu Val Ser Tyr Gly His Ile Gly Val Thr 210 215 220 Ile Leu Gln Ile Pro Ser Thr Lys Gly Ile Cys Lys Ala Leu Ser Thr 225 230 235 240 Cy s Gly Ser His Leu Ser Val Val Thr Ile Tyr Tyr Arg Thr Ile Ile 245 250 255 Gly Leu Tyr Phe Leu Pro Pro Ser Ser Asn Thr Asn Asp Lys Asn Ile 260 265 270 Ile Ala Ser Val Ile Tyr Thr Ala Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Ile Lys Gly Ala Leu Arg Lys Leu 290 295 300 Leu Ser Arg Ser Gly Ala Val Ala His Ala Cys Asn Leu Asn Thr Leu 305 310 315 320 Gly Gly <210> 583 <211> 1038 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1038) <400> 583 atg aat atc aca ctt tat tca ttt ctt tat gtc ctc aga tta aat gaa 48 Met Asn Ile Thr Leu Tyr Ser Phe Leu Tyr Val Leu Arg Leu Asn Glu 1 5 10 15 ggg aat agt act gga aga aat ata gat gaa aga aag aaa atg caa gga 96 Gly Asn Ser Thr Gly Arg Asn Ile Asp Glu Arg Lys Lys Met Gln Gly 20 25 30 gaa aac ttc acc att tgg agc att ttt ttc ttg gag gga ttt tcc cag 144 Glu Asn Phe Thr Ile Trp Ser Ile Phe Phe Leu Glu Gly Phe Ser Gln 35 40 45 tac cca ggg tta gaa gtg gtt ctc ttc gtc ttc agc ctt gta atg tat 192 Tyr Pro Gly Leu Glu Val Val Leu Phe Val Phe Ser Leu Val Met Tyr 50 55 60 ctg aca acg ctc ttg ggc aac agc act ctt att ttg atc act atc cta 240 Leu Thr Thr Leu Leu Gly Asn Ser Thr Leu Ile Leu Ile Thr Ile Leu 65 70 75 80 gat tca cgc ctt aaa acc ccc atg tac tta ttc ctt gga aat ctc tct 288 Asp Ser Arg Leu Lys Thr Pro Met Tyr Leu Phe Leu Gly Asn Leu Ser 85 90 95 ttc atg gat att tgt tac aca tct gcc tct gtt cct act ttg ctg gtg 336 Phe Met Asp Ile Cys Tyr Thr Ser Ala Ser Val Pro Thr Leu Leu Val 100 105 110 aac ttg ctg tca tcc cag aaa acc att atc ttt tct ggg tgt gct gta 384 Asn Leu Leu Ser Ser Gln Lys Thr Ile Ile Phe Ser Gly Cys Ala Val 115 120 125 cag atg tat ctg tcc ctt gcc atg ggc tcc aca gag tgt gtg ctc ctg 432 Gln Met Tyr Leu Ser Leu Ala Met Gly Ser Thr Glu Cys Val Leu Leu 130 135 140 gcc gtg atg gca tat gac cgt tat gtg gcc att tgt aac ccg ctg aga 480 Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn Pro Leu Arg 145 150 155 160 tac tcc atc atc atg aac agg tgc gtc tgt gca cgg atg gcc acg gtc 528 Tyr Ser Ile Ile Met Asn Arg Cys Val Cys Ala Arg Met Ala Thr Val 165 170 175 tcc tgg gtg acg ggt tgc ctg acc gct ctg ctg gaa acc agt ttt gcc 576 Ser Trp Val Thr Gly Cys Leu Thr Ala Leu Leu Glu Thr Ser Phe Ala 180 185 190 ctg cag ata ccc ctc tgt ggg aat ctc atc gat cac ttc acg tgt gaa 624 Leu Gln Ile Pro Leu Cys Gly Asn Leu Ile Asp His Phe Thr Cys Glu 195 200 205 att ctg gcg gtg cta aag tta gct tgc aca agt tca ctg ctc atg aac 672 Ile Leu Ala Val Leu Lys Leu Ala Cys Thr Ser Ser Leu Leu Met Asn 210 215 220 acc atc atg ctg gtg gtc agc att ctc ctc ttg cca att cca atg ctc 720 Thr Ile Met Leu Val Val Ser Ile Leu Leu Leu Pro Ile Pro Met Leu 225 230 235 240 tta gtt tgc atc tct tac atc ttc atc ctt tcc act att ctg aga atc 768 Leu Val Cys Ile Ser Tyr Ile Phe Ile Leu Ser Thr Ile Leu Arg Ile 245 250 255 acc tca gca gag gga aga aac aag gct ttt tct acc tgt ggt gcc cat 816 Thr Ser Ala Glu Gly Arg Asn Lys Ala Phe Ser Thr Cys Gly Ala His 260 265 270 ttg act gtg gtg att ttg tat tat ggg gct gcc ctc tct atg tac cta 864 Leu Thr Val Val Ile Leu Tyr Tyr Gly Ala Ala Leu Ser Met Tyr Leu 275 280 285 aag cct tct tca tca aat gca caa aaa ata gac aaa atc atc tcg ttg 912 Lys Pro Ser Ser Ser Asn Ala Gln Lys Ile Asp Lys Ile Ile Ser Leu 290 295 300 ctt tac gga gtg ctt acc cct atg ttg aac ccc ata att tac agt tta 960 Leu Tyr Gly Val Leu Thr Pro Met Leu Asn Pro Ile Ile Tyr Ser Leu 305 310 315 320 aga aac aag gaa gtc aaa gat gct atg aag aaa ttg ctg ggc aaa ata 1008 Arg Asn Lys Glu Val Lys Asp Ala Met Lys Lys Leu Leu Gly Lys Ile 325 330 335 aca ttg cat caa aca cac gaa cat ctc tga 1038 Thr Leu His Gln Thr His Glu His Leu 340 345 <210> 584 <211> 345 <212> PRT <213> Homo sapiens <400> 584 Met Asn Ile Thr Leu Tyr Ser Phe Leu Tyr Val Leu Arg Leu Asn Glu 1 5 10 15 Gly Asn Ser Thr Gly Arg Asn Ile Asp Glu Arg Lys Lys Met Gln Gly 20 25 30 Glu Asn Phe Thr Ile Trp Ser Ile Phe Phe Leu Glu Gly Phe Ser Gln 35 40 45 Tyr Pro Gly Leu Glu Val Val Leu Phe Val Phe Ser Leu Val Met Tyr 50 55 60 Leu Thr Thr Leu Leu Gly Asn Ser Thr Leu Ile Leu Ile Thr Ile Leu 65 70 75 80 Asp Ser Arg Leu Lys Thr Pro Met Tyr Leu Phe Leu Gly Asn Leu Ser 85 90 95 Phe Met Asp Ile Cys Tyr Thr Ser Ala Ser Val Pro Thr Leu Leu Val 100 105 110 Asn Leu Leu Ser Ser Gln Lys Thr Ile Ile Phe Ser Gly Cys Ala Val 115 120 125 Gln Met Tyr Leu Ser Leu Ala Met Gly Ser Thr Glu Cys Val Leu Leu 130 135 140 Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn Pro Leu Arg 145 150 155 160 Tyr Ser Ile Ile Met Asn Arg Cys Val Cys Ala Arg Met Ala Thr Val 165 170 175 Ser Trp Val Thr Gly Cys Leu Thr Ala Leu Leu Glu Thr Ser Phe Ala 180 185 190 Leu Gln Ile Pro Leu Cys Gly Asn Leu Ile Asp His Phe Thr Cys Glu 195 200 205 Ile Leu Ala Val Leu Lys Leu Ala Cys Thr Ser Ser Leu Leu Met Asn 210 215 220 Thr Ile Met Leu Val Val Ser Ile Leu Leu Leu Pro Ile Pro Met Leu 225 230 235 240 Leu Val Cys Ile Ser Tyr Ile Phe Ile Leu Ser Thr Ile Leu Arg Ile 245 250 255 Thr Ser Ala Glu Gly Arg Asn Lys Ala Phe Ser Thr Cys Gly Ala His 260 265 270 Leu Thr Val Val Ile Leu Tyr Tyr Gly Ala Ala Leu Ser Met Tyr Leu 275 280 285 Lys Pro Ser Ser Ser Asn Ala Gln Lys Ile Asp Lys Ile Ile Ser Leu 290 295 300 Leu Tyr Gly Val Leu Thr Pro Met Leu Asn Pro Ile Ile Tyr Ser Leu 305 310 315 320 Arg Asn Lys Glu Val Lys Asp Ala Met Lys Lys Leu Leu Gly Lys Ile 325 330 335 Thr Leu His Gln Thr His Glu His Leu 340 345 <210> 585 <211> 924 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(924) <400> 585 atg ggc caa cac aat cta aca gtg cta act gaa ttc att ctg atg gaa 48 Met Gly Gln His Asn Leu Thr Val Leu Thr Glu Phe Ile Leu Met Glu 1 5 10 15 ctc aca agg cgg cct gag ctg cag att ccc ctt ttt gga gtc ttc ctc 96 Leu Thr Arg Arg Pro Glu Leu Gln Ile Pro Leu Phe Gly Val Phe Leu 20 25 30 gtc atc tac cta atc aca gtg gtg ggc aac cta act atg atc att ttg 144 Val Ile Tyr Leu Ile Thr Val Val Gly Asn Leu Thr Met Ile Ile Leu 35 40 45 acc aaa ctg gac tcc cac tta cat aca cct atg tac ttt tct atc aga 192 Thr Lys Leu Asp Ser His Leu His Thr Pro Met Tyr Phe Ser Ile Arg 50 55 60 cat ttg gct tct gtt gat ctt ggt aat tct act gtc att tgt ccc aag 240 His Leu Ala Ser Val Asp Leu Gly Asn Ser Thr Val Ile Cys Pro Lys 65 70 75 80 gtg ctg gca aat ttt gtt gtg gat cga aat act att tcc tat tat gca 288 Val Leu Ala Asn Phe Val Val Asp Arg Asn Thr Ile Ser Tyr Tyr Ala 85 90 95 tgt gct gca cag ctg gca ttc ttc ctt atg ttc att atc agt gaa ttt 336 Cys Ala Ala Gln Leu Ala Phe Phe Leu Met Phe Ile Ile Ser Glu Phe 100 105 110 ttc atc ctg tca gcc atg gcc tat gac cgc tat gtg gcc att tgt aac 384 Phe Ile Leu Ser Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 cct ctg ctc tat tat gtt att atg tct cag cga ctg tgt cat gta ctg 432 Pro Leu Leu Tyr Tyr Val Ile Met Ser Gln Arg Leu Cys His Val Leu 130 135 140 gtg ggc att caa tat ctc tac agc aca ttt cag gct ctg atg ttc act 480 Val Gly Ile Gln Tyr Leu Tyr Ser Thr Phe Gln Ala Leu Met Phe Thr 145 150 155 160 att aag att ttt aca ttg acc ttc tgt ggc tct aat gtc atc agt cat 528 Ile Lys Ile Phe Thr Leu Thr Phe Cys Gly Ser Asn Val Ile Ser His 165 170 175 ttt tac tgt gat gat gtt cct ttg cta cct atg ctt tgc tca aat gca 576 Phe Tyr Cys Asp Asp Val Pro Leu Leu Pro Met Leu Cys Ser Asn Ala 180 185 190 cag gaa ata gaa ttg ttg agc ata cta ttt tct gta ttt aat ttg atc 624 Gln Glu Ile Glu Leu Leu Ser Ile Leu Phe Ser Val Phe Asn Leu Ile 195 200 205 tcc tcc ttt ctg ata gtc tta gtg tcc tac atg ttg att ttg tta gct 672 Ser Ser Phe Leu Ile Val Leu Val Ser Tyr Met Leu Ile Leu Leu Ala 210 215 220 ata tgt caa atg cat tct gca gag ggc agg aaa aag gct ttc tcc aca 720 Ile Cys Gln Met His Ser Ala Glu Gly Arg Lys Lys Ala Phe Ser Thr 225 230 235 240 tgt ggt tcc cat ttg aca gtg gtg gtt gtg ttc tat ggg tct cta ctc 768 Cys Gly Ser His Leu Thr Val Val Val Val Phe Tyr Gly Ser Leu Leu 245 250 255 ttc atg tac atg cag ccc aat tcc act cac ttc ttt gat act gat aaa 816 Phe Met Tyr Met Gln Pro Asn Ser Thr His Phe Phe Asp Thr Asp Lys 260 265 270 atg gct tct gtg ttt tac act tta gta atc ccc atg ctt aac cct ttg 864 Met Ala Ser Val Phe Tyr Thr Leu Val Ile Pro Met Leu Asn Pro Leu 275 280 285 att tac agc tta aga aac gaa gag gtg aaa aat gcc ttc tat aag ctc 912 Ile Tyr Ser Leu Arg Asn Glu Glu Val Lys Asn Ala Phe Tyr Lys Leu 290 295 300 ttt gag aat tga 924 Phe Glu Asn 305 <210> 586 <211> 307 <212> PRT <213> Homo sapiens <400> 586 Met Gly Gln His Asn Leu Thr Val Leu Thr Glu Phe Ile Leu Met Glu 1 5 10 15 Leu Thr Arg Arg Pro Glu Leu Gln Ile Pro Leu Phe Gly Val Phe Leu 20 25 30 Val Ile Tyr Leu Ile Thr Val Val Gly Asn Leu Thr Met Ile Ile Leu 35 40 45 Thr Lys Leu Asp Ser His Leu His Thr Pro Met Tyr Phe Ser Ile Arg 50 55 60 His Leu Ala Ser Val Asp Leu Gly Asn Ser Thr Val Ile Cys Pro Lys 65 70 75 80 Val Leu Ala Asn Phe Val Val Asp Arg Asn Thr Ile Ser Tyr Tyr Ala 85 90 95 Cys Ala Ala Gln Leu Ala Phe Phe Leu Met Phe Ile Ile Ser Glu Phe 100 105 110 Phe Ile Leu Ser Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Tyr Val Ile Met Ser Gln Arg Leu Cys His Val Leu 130 135 140 Val Gly Ile Gln Tyr Leu Tyr Ser Thr Phe Gln Ala Leu Met Phe Thr 145 150 155 160 Ile Lys Ile Phe Thr Leu Thr Phe Cys Gly Ser Asn Val Ile Ser His 165 170 175 Phe Tyr Cys Asp Asp Val Pro Leu Leu Pro Met Leu Cys Ser Asn Ala 180 185 190 Gln Glu Ile Glu Leu Leu Ser Ile Leu Phe Ser Val Phe Asn Leu Ile 195 200 205 Ser Ser Phe Leu Ile Val Leu Val Ser Tyr Met Leu Ile Leu Leu Ala 210 215 220 Ile Cys Gln Met His Ser Ala Glu Gly Arg Lys Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Thr Val Val Val Val Phe Tyr Gly Ser Leu Leu 245 250 255 Phe Met Tyr Met Gln Pro Asn Ser Thr His Phe Phe Asp Thr Asp Lys 260 265 270 Met Ala Ser Val Phe Tyr Thr Leu Val Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Glu Glu Val Lys Asn Ala Phe Tyr Lys Leu 290 295 300 Phe Glu Asn 305 <210> 587 <211> 948 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(948) <400> 587 atg gct cct gaa aat ttc acc agg gtc act gag ttt att ctc aca ggt 48 Met Ala Pro Glu Asn Phe Thr Arg Val Thr Glu Phe Ile Leu Thr Gly 1 5 10 15 gtc tct agc tgt cca gag ctc cag att ccc ctc ttc ctg gtc ttc cta 96 Val Ser Ser Cys Pro Glu Leu Gln Ile Pro Leu Phe Leu Val Phe Leu 20 25 30 gtg ctc tat gtg ctg acc atg gca ggg aac ctg ggc atc atc acc ctc 144 Val Leu Tyr Val Leu Thr Met Ala Gly Asn Leu Gly Ile Ile Thr Leu 35 40 45 acc agt gtt gac tct cga ctt caa acc ccc atg tac ttt ttc ctg aga 192 Thr Ser Val Asp Ser Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg 50 55 60 cat cta gct atc atc aat ctt ggc aac tct act gtc att gcc cct aaa 240 His Leu Ala Ile Ile Asn Leu Gly Asn Ser Thr Val Ile Ala Pro Lys 65 70 75 80 atg ctg atg aac ttt tta gta aag aag aaa act acc tca ttc tat gaa 288 Met Leu Met Asn Phe Leu Val Lys Lys Lys Thr Thr Ser Phe Tyr Glu 85 90 95 tgt gcc acc caa ctg gga ggg ttc ttg ttc ttt att gta tcg gag gta 336 Cys Ala Thr Gln Leu Gly Gly Phe Leu Phe Phe Ile Val Ser Glu Val 100 105 110 atg atg ctg gct gtg atg gcc tat gac cgc tat gtg gcc att tgt aac 384 Met Met Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 cct ctg ctc tac atg gtg gtg gtg tct cgg cgg ctc tgc ctc ctg ctg 432 Pro Leu Leu Tyr Met Val Val Val Ser Arg Arg Leu Cys Leu Leu Leu 130 135 140 gtg tcc ctc acg tac ctc tat ggc ttt tct aca gct att gtg gtt tca 480 Val Ser Leu Thr Tyr Leu Tyr Gly Phe Ser Thr Ala Ile Val Val Ser 145 150 155 160 cct tgt ata ttc tct gtg tct tat tgc tct tct aat ata atc aat cat 528 Pro Cys Ile Phe Ser Val Ser Tyr Cys Ser Ser Asn Ile Ile Asn His 165 170 175 ttt tac tgt gat att gca cct ctg tta gca tta tct tgc tct gat act 576 Phe Tyr Cys Asp Ile Ala Pro Leu Leu Ala Leu Ser Cys Ser Asp Thr 180 185 190 tac ata cca gaa aca ata gtc ttt ata tct gca gca aca aat ttg ttt 624 Tyr Ile Pro Glu Thr Ile Val Phe Ile Ser Ala Ala Thr Asn Leu Phe 195 200 205 ttt tcc atg att aca gtt cta gta tct tat ttc aat att gtt ttg tcc 672 Phe Ser Met Ile Thr Val Leu Val Ser Tyr Phe Asn Ile Val Leu Ser 210 215 220 att cta agg ata cgt tca cca gaa gga agg aaa aaa gcc ttt tcc acc 720 Ile Leu Arg Ile Arg Ser Pro Glu Gly Arg Lys Lys Ala Phe Ser Thr 225 230 235 240 tgc gct tcg cat atg ata gca gtc acg gtt ttc tat ggg aca atg cta 768 Cys Ala Ser His Met Ile Ala Val Thr Val Phe Tyr Gly Thr Met Leu 245 250 255 ttt atg tat ttg cag ccc caa acc aac cac tca ctg gat act gat aag 816 Phe Met Tyr Leu Gln Pro Gln Thr Asn His Ser Leu Asp Thr Asp Lys 260 265 270 atg gct tct gtg ttt tac aca ttg gtg att cct atg ctg aat ccc ttg 864 Met Ala Ser Val Phe Tyr Thr Leu Val Ile Pro Met Leu Asn Pro Leu 275 280 285 atc tac agc ctg agg aat aat gat gta aat gtt gcc tta aag aaa ttc 912 Ile Tyr Ser Leu Arg Asn Asn Asp Val Asn Val Ala Leu Lys Lys Phe 290 295 300 atg gaa aat cca tgt tac tcc ttt aaa tca atg taa 948 Met Glu Asn Pro Cys Tyr Ser Phe Lys Ser Met 305 310 315 <210> 588 <211> 315 <212> PRT <213> Homo sapiens <400> 588 Met Ala Pro Glu Asn Phe Thr Arg Val Thr Glu Phe Ile Leu Thr Gly 1 5 10 15 Val Ser Ser Cys Pro Glu Leu Gln Ile Pro Leu Phe Leu Val Phe Leu 20 25 30 Val Leu Tyr Val Leu Thr Met Ala Gly Asn Leu Gly Ile Ile Thr Leu 35 40 45 Thr Ser Val Asp Ser Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg 50 55 60 His Leu Ala Ile Ile Asn Leu Gly Asn Ser Thr Val Ile Ala Pro Lys 65 70 75 80 Met Leu Met Asn Phe Leu Val Lys Lys Lys Thr Thr Ser Phe Tyr Glu 85 90 95 Cys Ala Thr Gln Leu Gly Gly Phe Leu Phe Phe Ile Val Ser Glu Val 100 105 110 Met Met Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Met Val Val Val Ser Arg Arg Leu Cys Leu Leu Leu 130 135 140 Val Ser Leu Thr Tyr Leu Tyr Gly Phe Ser Thr Ala Ile Val Val Ser 145 150 155 160 Pro Cys Ile Phe Ser Val Ser Tyr Cys Ser Ser Asn Ile Ile Asn His 165 170 175 Phe Tyr Cys Asp Ile Ala Pro Leu Leu Ala Leu Ser Cys Ser Asp Thr 180 185 190 Tyr Ile Pro Glu Thr Ile Val Phe Ile Ser Ala Ala Thr Asn Leu Phe 195 200 205 Phe Ser Met Ile Thr Val Leu Val Ser Tyr Phe Asn Ile Val Leu Ser 210 215 220 Ile Leu Arg Ile Arg Ser Pro Glu Gly Arg Lys Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Met Ile Ala Val Thr Val Phe Tyr Gly Thr Met Leu 245 250 255 Phe Met Tyr Leu Gln Pro Gln Thr Asn His Ser Leu Asp Thr Asp Lys 260 265 270 Met Ala Ser Val Phe Tyr Thr Leu Val Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Asn Asp Val Asn Val Ala Leu Lys Lys Phe 290 295 300 Met Glu Asn Pro Cys Tyr Ser Phe Lys Ser Met 305 310 315 <210> 589 <211> 861 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(861) <400> 589 atg ggg gcc atc aag ctc agc cac aac ctt cac act cct atg tac ttt 48 Met Gly Ala Ile Lys Leu Ser His Asn Leu His Thr Pro Met Tyr Phe 1 5 10 15 ttc ctc tgt ggc ctg tcc ttt tca gaa act tgt acc act gtg gta gta 96 Phe Leu Cys Gly Leu Ser Phe Ser Glu Thr Cys Thr Thr Val Val Val 20 25 30 atc cct cgc atg ttg gtg gac ttt cta tca gag agc aag acc att tct 144 Ile Pro Arg Met Leu Val Asp Phe Leu Ser Glu Ser Lys Thr Ile Ser 35 40 45 ctt cct gag tgt gcc aca cag atg ttt ttc ttt ctg ggc ttt gca tcc 192 Leu Pro Glu Cys Ala Thr Gln Met Phe Phe Phe Leu Gly Phe Ala Ser 50 55 60 aac aac tgt ttc atc atg gcc gct atg tcc tac gac cgc tac acg gcc 240 Asn Asn Cys Phe Ile Met Ala Ala Met Ser Tyr Asp Arg Tyr Thr Ala 65 70 75 80 atc cac aac cca ctg cag tac cac acc ctt atg aca aga aag atc tgc 288 Ile His Asn Pro Leu Gln Tyr His Thr Leu Met Thr Arg Lys Ile Cys 85 90 95 ttg cag atg atg atg gct tct tgg atg gtt ggg ttc ctg ttt tct ctg 336 Leu Gln Met Met Met Ala Ser Trp Met Val Gly Phe Leu Phe Ser Leu 100 105 110 tgc atc atc gtc act gta ttc aac ttg tct ctt tgc gac ttg aac act 384 Cys Ile Ile Val Thr Val Phe Asn Leu Ser Leu Cys Asp Leu Asn Thr 115 120 125 atc cag cac tat ttc tgt gat atc tca cca gtg gtc tcc ctt gct tgt 432 Ile Gln His Tyr Phe Cys Asp Ile Ser Pro Val Val Ser Leu Ala Cys 130 135 140 aat tac act ttc tat cat gaa atg gct att ttt gtg ctc tct gcc ttt 480 Asn Tyr Thr Phe Tyr His Glu Met Ala Ile Phe Val Leu Ser Ala Phe 145 150 155 160 gtg ttg gtg ggc agc tgt att tta att atg att tcc tat gtc ttc att 528 Val Leu Val Gly Ser Cys Ile Leu Ile Met Ile Ser Tyr Val Phe Ile 165 170 175 gtg ttc ata gtc ata aag atg ccc tct gca aag ggg agg tct aag gcc 576 Val Phe Ile Val Ile Lys Met Pro Ser Ala Lys Gly Arg Ser Lys Ala 180 185 190 ttc tca act tgc tcc tcc cac ctc act gtt gtg tcc ata cac tat gga 624 Phe Ser Thr Cys Ser Ser His Leu Thr Val Val Ser Ile His Tyr Gly 195 200 205 ttt gct tgc ttt gtc tat ttg agg ccc aag aac agc aac tcc ttc gat 672 Phe Ala Cys Phe Val Tyr Leu Arg Pro Lys Asn Ser Asn Ser Phe Asp 210 215 220 gaa gac atg ctg acg gcc atg ata tat aca ata ctg atg cct ctg ctt 720 Glu Asp Met Leu Thr Ala Met Ile Tyr Thr Ile Leu Met Pro Leu Leu 225 230 235 240 aac ccc atc gtg tac agt ctg aga aac aaa gaa atg cag ata gcc cta 768 Asn Pro Ile Val Tyr Ser Leu Arg Asn Lys Glu Met Gln Ile Ala Leu 245 250 255 aga aaa aca cta ggc agt gta ttt ggg gtt ttc cct cag aag aca aaa 816 Arg Lys Thr Leu Gly Ser Val Phe Gly Val Phe Pro Gln Lys Thr Lys 260 265 270 aaa gag cct gaa cat tta aaa aaa tta cac agc att gat aaa taa 861 Lys Glu Pro Glu His Leu Lys Lys Leu His Ser Ile Asp Lys 275 280 285 <210> 590 <211> 286 <212> PRT <213> Homo sapiens <400> 590 Met Gly Ala Ile Lys Leu Ser His Asn Leu His Thr Pro Met Tyr Phe 1 5 10 15 Phe Leu Cys Gly Leu Ser Phe Ser Glu Thr Cys Thr Thr Val Val Val 20 25 30 Ile Pro Arg Met Leu Val Asp Phe Leu Ser Glu Ser Lys Thr Ile Ser 35 40 45 Leu Pro Glu Cys Ala Thr Gln Met Phe Phe Phe Leu Gly Phe Ala Ser 50 55 60 Asn Asn Cys Phe Ile Met Ala Ala Met Ser Tyr Asp Arg Tyr Thr Ala 65 70 75 80 Ile His Asn Pro Leu Gln Tyr His Thr Leu Met Thr Arg Lys Ile Cys 85 90 95 Leu Gln Met Met Met Ala Ser Trp Met Val Gly Phe Leu Phe Ser Leu 100 105 110 Cys Ile Ile Val Thr Val Phe Asn Leu Ser Leu Cys Asp Leu Asn Thr 115 120 125 Ile Gln His Tyr Phe Cys Asp Ile Ser Pro Val Val Ser Leu Ala Cys 130 135 140 Asn Tyr Thr Phe Tyr His Glu Met Ala Ile Phe Val Leu Ser Ala Phe 145 150 155 160 Val Leu Val Gly Ser Cys Ile Leu Ile Met Ile Ser Tyr Val Phe Ile 165 170 175 Val Phe Ile Val Ile Lys Met Pro Ser Ala Lys Gly Arg Ser Lys Ala 180 185 190 Phe Ser Thr Cys Ser Ser His Leu Thr Val Val Ser Ile His Tyr Gly 195 200 205 Phe Ala Cys Phe Val Tyr Leu Arg Pro Lys Asn Ser Asn Ser Phe Asp 210 215 220 Glu Asp Met Leu Thr Ala Met Ile Tyr Thr Ile Leu Met Pro Leu Leu 225 230 235 240 Asn Pro Ile Val Tyr Ser Leu Arg Asn Lys Glu Met Gln Ile Ala Leu 245 250 255 Arg Lys Thr Leu Gly Ser Val Phe Gly Val Phe Pro Gln Lys Thr Lys 260 265 270 Lys Glu Pro Glu His Leu Lys Lys Leu His Ser Ile Asp Lys 275 280 285 <210> 591 <211> 657 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(657) <400> 591 atg ttc ctc tcc ctt gcc atg gga gcc aca gag tgt gtt ctc ctg agc 48 Met Phe Leu Ser Leu Ala Met Gly Ala Thr Glu Cys Val Leu Leu Ser 1 5 10 15 atg atg gcg ttt gat cgc tac gtg gcc atc tgc aac ccc ctt tgg tac 96 Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn Pro Leu Trp Tyr 20 25 30 cct gaa gtc atg aac aaa gct act tat gtg ccc atg gct gct ggc tcc 144 Pro Glu Val Met Asn Lys Ala Thr Tyr Val Pro Met Ala Ala Gly Ser 35 40 45 tgg gta gct gga agc ctc act gcc atg gtg cag aca ccc ctt gca ttg 192 Trp Val Ala Gly Ser Leu Thr Ala Met Val Gln Thr Pro Leu Ala Leu 50 55 60 agg ctg ccc ttc tgt gga gac aac atc atc aat cac ttc acc tgt gag 240 Arg Leu Pro Phe Cys Gly Asp Asn Ile Ile Asn His Phe Thr Cys Glu 65 70 75 80 att ctg gct gtc ctg aag ttg gcc tgt gct gat atc tct gtc aat gtg 288 Ile Leu Ala Val Leu Lys Leu Ala Cys Ala Asp Ile Ser Val Asn Val 85 90 95 atc agt atg gga gtg gcc aat gtg atc ttc ctg ggg gtc cct gtt ctg 336 Ile Ser Met Gly Val Ala Asn Val Ile Phe Leu Gly Val Pro Val Leu 100 105 110 ttc atc tct ttc tcc tat gtc ttc atc att gcc acc atc ctg agg atc 384 Phe Ile Ser Phe Ser Tyr Val Phe Ile Ile Ala Thr Ile Leu Arg Ile 115 120 125 ccc tca gct gag ggg agg aaa aag gcc ttc tcc acc tgc tct gcc cac 432 Pro Ser Ala Glu Gly Arg Lys Lys Ala Phe Ser Thr Cys Ser Ala His 130 135 140 ctc act gtc gtg atc gtc ttc tac ggg acc atc ctc ttc atg tac ggg 480 Leu Thr Val Val Ile Val Phe Tyr Gly Thr Ile Leu Phe Met Tyr Gly 145 150 155 160 aag ccc aag tct aag gac cca ctg gga gca gac aaa cag gac ctt gca 528 Lys Pro Lys Ser Lys Asp Pro Leu Gly Ala Asp Lys Gln Asp Leu Ala 165 170 175 gac aaa ctc att tcc ctt ttc tat ggg gtg gtg acc ccc atg ctc aac 576 Asp Lys Leu Ile Ser Leu Phe Tyr Gly Val Val Thr Pro Met Leu Asn 180 185 190 ccc atc atc tac agc ctg agg aac aag gaa gtg aag gct gct gtg agg 624 Pro Ile Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Ala Ala Val Arg 195 200 205 aac ctg gta ttt cag aaa cgc ttc ctg cag tga 657 Asn Leu Val Phe Gln Lys Arg Phe Leu Gln 210 215 <210> 592 <211> 218 <212> PRT <213> Homo sapiens <400> 592 Met Phe Leu Ser Leu Ala Met Gly Ala Thr Glu Cys Val Leu Leu Ser 1 5 10 15 Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn Pro Leu Trp Tyr 20 25 30 Pro Glu Val Met Asn Lys Ala Thr Tyr Val Pro Met Ala Ala Gly Ser 35 40 45 Trp Val Ala Gly Ser Leu Thr Ala Met Val Gln Thr Pro Leu Ala Leu 50 55 60 Arg Leu Pro Phe Cys Gly Asp Asn Ile Ile Asn His Phe Thr Cys Glu 65 70 75 80 Ile Leu Ala Val Leu Lys Leu Ala Cys Ala Asp Ile Ser Val Asn Val 85 90 95 Ile Ser Met Gly Val Ala Asn Val Ile Phe Leu Gly Val Pro Val Leu 100 105 110 Phe Ile Ser Phe Ser Tyr Val Phe Ile Ile Ala Thr Ile Leu Arg Ile 115 120 125 Pro Ser Ala Glu Gly Arg Lys Lys Ala Phe Ser Thr Cys Ser Ala His 130 135 140 Leu Thr Val Val Ile Val Phe Tyr Gly Thr Ile Leu Phe Met Tyr Gly 145 150 155 160 Lys Pro Lys Ser Lys Asp Pro Leu Gly Ala Asp Lys Gln Asp Leu Ala 165 170 175 Asp Lys Leu Ile Ser Leu Phe Tyr Gly Val Val Thr Pro Met Leu Asn 180 185 190 Pro Ile Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Ala Ala Val Arg 195 200 205 Asn Leu Val Phe Gln Lys Arg Phe Leu Gln 210 215 <210> 593 <211> 627 <212> DNA <2 13> Homo sapiens <220> <221> CDS <222> (1)..(627) <400> 593 atg ggg gac aac caa tca cgg gtc aca gaa ttc atc ctg gtt gga ttc 48 Met Gly Asp Asn Gln Ser Arg Val Thr Glu Phe Ile Leu Val Gly Phe 1 5 10 15 cag ctc agt gtg gag atg gaa gtg ctc ctc ttc tgg atc ttc tcc ctg 96 Gln Leu Ser Val Glu Met Glu Val Leu Leu Phe Trp Ile Phe Ser Leu 20 25 30 tta tat ctc ttc agc ctg ctg ggg aat ggg gtc atc ttt ggg ctc atc 144 Leu Tyr Leu Phe Ser Leu Leu Gly Asn Gly Val Ile Phe Gly Leu Ile 35 40 45 tgc ctg gac tct aag ctt cac acc ccc atg tac ttc ttc ctc tca cac 192 Cys Leu Asp Ser Lys Leu His Thr Pro Met Tyr Phe Phe Leu Ser His 50 55 60 ctg gcc gtc att gac atg tcc tat gct tcc aac aat gtt ccc aag atg 240 Leu Ala Val Ile Asp Met Ser Tyr Ala Ser Asn Asn Val Pro Lys Met 65 70 75 80 ctg gca aac cta gtg aac cag aaa aga act atc tcg ttc atc tct tgc 288 Leu Ala Asn Leu Val Asn Gln Lys Arg Thr Ile Ser Phe Ile Ser Cys 85 90 95 ata atg cag act ttt ttg tat ttg gct ttt gct gtt aca gtg tgc ctg 336 Ile Met Gln Thr Phe Leu Tyr Leu Ala Phe Ala Val Thr Val Cys Leu 100 105 110 att ttg gtg gtg atg tcc tat gac aga ttt gtg gcc atc tgc cat ccc 384 Ile Leu Val Val Met Ser Tyr Asp Arg Phe Val Ala Ile Cys His Pro 115 120 125 ctg cat tac act gtc atc atg agc tgg aga gtg tgc act gtc ctg gct 432 Leu His Tyr Thr Val Ile Met Ser Trp Arg Val Cys Thr Val Leu Ala 130 135 140 gtg gct tcc tgg gtg ttc agc ttc ctc ctg gct ctg gtc cat tta gtt 480 Val Ala Ser Trp Val Phe Ser Phe Leu Leu Ala Leu Val His Leu Val 145 150 155 160 ctc att ctg agg ctg ccc ttc tgt ggg ccc cag gag gtg aac cac ttc 528 Leu Ile Leu Arg Leu Pro Phe Cys Gly Pro Gln Glu Val Asn His Phe 165 170 175 ttc ggt gaa atc ctg tct gtc ctc aag ttg gcc tgt gct gac acc tgg 576 Phe Gly Glu Ile Leu Ser Val Leu Lys Leu Ala Cys Ala Asp Thr Trp 180 185 190 ctc aac cag gtg gtc atc ttt gca gcc tgc atg ttc atc ctg gta ggg 624 Leu Asn Gln Val Val Ile Phe Ala Ala Cys Met Phe Ile Leu Val Gly 195 200 205 tga 627 <210> 594 <211> 208 <212> PRT <213> Homo sapiens <400> 594 Met Gly Asp Asn Gln Ser Arg Val Thr Glu Phe Ile Leu Val Gly Phe 1 5 10 15 Gln Leu Ser Val Glu Met Glu Val Leu Leu Phe Trp Ile Phe Ser Leu 20 25 30 Leu Tyr Leu Phe Ser Leu Leu Gly Asn Gly Val Ile Phe Gly Leu Ile 35 40 45 Cys Leu Asp Ser Lys Leu His Thr Pro Met Tyr Phe Phe Leu Ser His 50 55 60 Leu Ala Val Ile Asp Met Ser Tyr Ala Ser Asn Asn Val Pro Lys Met 65 70 75 80 Leu Ala Asn Leu Val Asn Gln Lys Arg Thr Ile Ser Phe Ile Ser Cys 85 90 95 Ile Met Gln Thr Phe Leu Tyr Leu Ala Phe Ala Val Thr Val Cys Leu 100 105 110 Ile Leu Val Val Met Ser Tyr Asp Arg Phe Val Ala Ile Cys His Pro 115 120 125 Leu His Tyr Thr Val Ile Met Ser Trp Arg Val Cys Thr Val Leu Ala 130 135 140 Val Ala Ser Trp Val Phe Ser Phe Leu Leu Ala Leu Val His Leu Val 145 150 155 160 Leu Ile Leu Arg Leu Pro Phe Cys Gly Pro Gln Glu Val Asn His Phe 165 170 175 Phe Gly Glu Ile Leu Ser Val Leu Lys Leu Ala Cys Ala Asp Thr Trp 180 185 190 Leu Asn Gln Val Val Ile Phe Ala Ala Cys Met Phe Ile Leu Val Gly 195 200 205 <210> 595 <211> 1134 <212> DNA <213> Homo sapiens <2 20> <221> CDS <222> (1)..(1134) <400> 595 atg aat gat gca aat ccc cat ttc cat nnn nnn nnn nnn nnn nnn nnn 48 Met Asn Asp Ala Asn Pro His Phe His Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn 96 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 20 25 30 nnn nnn nnn nnn nnn nnn nnn nnn nnn nnn ngt gct ctt ccc aca ggt 144 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Leu Pro Thr Gly 35 40 45 ggc ctt ttg ccc cac ccc cag cat aca atg atg gaa ata gcc aat gtg 192 Gly Leu Leu Pro His Pro Gln His Thr Met Met Glu Ile Ala Asn Val 50 55 60 agt tct cca gaa gtc ttt gtc ctc ctg ggc ttc tcc aca cga ccc tca 240 Ser Ser Pro Glu Val Phe Val Leu Leu Gly Phe Ser Thr Arg Pro Ser 65 70 75 80 cta gaa act gtc ctc ttc ata gtt gtc ttg agt ttt tac atg gta tcg 288 Leu Glu Thr Val Leu Phe Ile Val Val Leu Ser Phe Tyr Met Val Ser 85 90 95 atc ttg ggc aat ggc atc atc att ctg gtc tcc cat aca gat gtg cac 336 Ile Leu Gly Asn Gly Ile Ile Ile Leu Val Ser His Thr Asp Val His 100 105 110 ctc cac aca cct atg tac ttc ttt ctt gcc aac ctc ccc ttc ctg gac 384 Leu His Thr Pro Met Tyr Phe Phe Leu Ala Asn Leu Pro Phe Leu Asp 115 120 125 atg agc ttc acc acg agc att gtc cca cag ctc ctg gct aac ctc tgg 432 Met Ser Phe Thr Thr Ser Ile Val Pro Gln Leu Leu Ala Asn Leu Trp 130 135 140 gga cca cag aaa acc ata agc tat gga ggg tgt gtg gtc cag ttc tat 480 Gly Pro Gln Lys Thr Ile Ser Tyr Gly Gly Cys Val Val Gln Phe Tyr 145 150 155 160 atc tcc cat tgg ctg ggg gca acc gag tgt gtc ctg ctg gcc acc atg 528 Ile Ser His Trp Leu Gly Ala Thr Glu Cys Val Leu Leu Ala Thr Met 165 170 175 tcc tat gac cgc tac gct gcc atc tgc agg cca ctc cat tac act gtc 576 Ser Tyr Asp Arg Tyr Ala Ala Ile Cys Arg Pro Leu His Tyr Thr Val 180 185 190 att atg cat cca cag ctt tgc ctt ggg cta gct ttg gcc tcc tgg ctg 624 Ile Met His Pro Gln Leu Cys Leu Gly Leu Ala Leu Ala Ser Trp Leu 195 200 205 ggg ggt ctg acc acc agc atg gtg ggc tcc acg ctc acc atg ctc cta 672 Gly Gly Leu Thr Thr Ser Met Val Gly Ser Thr Leu Thr Met Leu Leu 210 215 220 ccg ctg tgt ggg aac aat tgc atc gac cac ttc ttt tgc gag atg ccc 720 Pro Leu Cys Gly Asn Asn Cys Ile Asp His Phe Phe Cys Glu Met Pro 225 230 235 240 ctc att atg caa ctg gct tgt gtg gat acc agc ctc aat gag atg gag 768 Leu Ile Met Gln Leu Ala Cys Val Asp Thr Ser Leu Asn Glu Met Glu 245 250 255 atg tac ctg gcc agc ttt gtc ttt gtt gtc ctg cct ctg ggg ctc atc 816 Met Tyr Leu Ala Ser Phe Val Phe Val Val Leu Pro Leu Gly Leu Ile 260 265 270 ctg gtc tct tac ggc cac att gcc cgg gcc gtg ttg aag atc agg tca 864 Leu Val Ser Tyr Gly His Ile Ala Arg Ala Val Leu Lys Ile Arg Ser 275 280 285 gca gaa ggg cgg aga aag gca ttc aac acc tgt tct tcc cac gtg gct 912 Ala Glu Gly Arg Arg Lys Ala Phe Asn Thr Cys Ser Ser His Val Ala 290 295 300 gtg gtg tct ctg ttt tac ggg agc atc atc ttc atg tat ctc cag cca 960 Val Val Ser Leu Phe Tyr Gly Ser Ile Ile Phe Met Tyr Leu Gln Pro 305 310 315 320 gcc aag agc acc tcc cat gag cag ggc aag ttc ata gct ctg ttc tac 1008 Ala Lys Ser Thr Ser His Glu Gln Gly Lys Phe Ile Ala Leu Phe Tyr 325 330 335 acc gta gtc act cct gcg ctg aac cca ctt att tac acc ctg agg aac 1056 Thr Val Val Thr Pro Ala Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn 340 345 350 acg gag gtg aag agc gcc ctc cgg cac atg gta tta gag aac tgc tgt 1104 Thr Glu Val Lys Ser Ala Leu Arg His Met Val Leu Glu Asn Cys Cys 355 360 365 ggc tct gca ggc aag ctg gcg caa att tag 1134 Gly Ser Ala Gly Lys Leu Ala Gln Ile 370 375 <210> 596 <211> 377 <212> PRT <213> Homo sapiens <400> 596 Met Asn Asp Ala Asn Pro His Phe His Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 20 25 30 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Leu Pro Thr Gly 35 40 45 Gly Leu Leu Pro His Pro Gln His Thr Met Met Glu Ile Ala Asn Val 50 55 60 Ser Ser Pro Glu Val Phe Val Leu Leu Gly Phe Ser Thr Arg Pro Ser 65 70 75 80 Leu Glu Thr Val Leu Phe Ile Val Val Leu Ser Phe Tyr Met Val Ser 85 90 95 Ile Leu Gly Asn Gly Ile Ile Ile Leu Val Ser His Thr Asp Val His 100 105 110 Leu His Thr Pro Met Tyr Phe Phe Leu Ala Asn Leu Pro Phe Leu Asp 115 120 125 Met Ser Phe Thr Thr Ser Ile Val Pro Gln Leu Leu Ala Asn Leu Trp 130 135 140 Gly Pro Gln Lys Thr Ile Ser Tyr Gly Gly Cys Val Val Gln Phe Tyr 145 150 155 160 Ile Ser His Trp Leu Gly Ala Thr Glu Cys Val Leu Leu Ala Thr Met 165 170 175 Ser Tyr Asp Arg Tyr Ala Ala Ile Cys Arg Pro Leu His Tyr Thr Val 180 185 190 Ile Met His Pro Gln Leu Cys Leu Gly Leu Ala Leu Ala Ser Trp Leu 195 200 205 Gly Gly Leu Thr Thr Ser Met Val Gly Ser Thr Leu Thr Met Leu Leu 210 215 220 Pro Leu Cys Gly Asn Asn Cys Ile Asp His Phe Phe Cys Glu Met Pro 225 230 235 240 Leu Ile Met Gln Leu Ala Cys Val Asp Thr Ser Leu Asn Glu Met Glu 245 250 255 Met Tyr Leu Ala Ser Phe Val Phe Val Val Leu Pro Leu Gly Leu Ile 260 265 270 Leu Val Ser Tyr Gly His Ile Ala Arg Ala Val Leu Lys Ile Arg Ser 275 280 285 Ala Glu Gly Arg Arg Lys Ala Phe Asn Thr Cys Ser Ser His Val Ala 290 295 300 Val Val Ser Leu Phe Tyr Gly Ser Ile Ile Phe Met Tyr Leu Gln Pro 305 310 315 320 Ala Lys Ser Thr Ser His Glu Gln Gly Lys Phe Ile Ala Leu Phe Tyr 325 330 335 Thr Val Val Thr Pro Ala Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn 340 345 350 Thr Glu Val Lys Ser Ala Leu Arg His Met Val Leu Glu Asn Cys Cys 355 360 365 Gly Ser Ala Gly Lys Leu Ala Gln Ile 370 375 <210> 597 <211> 861 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(861) <400> 597 atg ggg gaa aat cag aca atg gtc aca gag ttc ctc cta ctg gga ttt 48 Met Gly Glu Asn Gln Thr Met Val Thr Glu Phe Leu Leu Leu Gly Phe 1 5 10 15 ctc ctg ggc cca agg att cag atg ctc ctc ttt ggg ctc ttc tcc ctg 96 Leu Leu Gly Pro Arg Ile Gln Met Leu Leu Phe Gly Leu Phe Ser Leu 20 25 30 ttc tat atc ttc acc ctg ctg ggg aac ggg gcc atc ctg ggg ctc atc 144 Phe Tyr Ile Phe Thr Leu Leu Gly Asn Gly Ala Ile Leu Gly Leu Ile 35 40 45 tca ctg gac tcc aga ctc cac acc ccc atg tac ttc ttc ctc tca cac 192 Ser Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser His 50 55 60 ctg gct gtc gtc gac atc gcc tac acc cgc aac acg gtg ccc cag atg 240 Leu Ala Val Val Asp Ile Ala Tyr Thr Arg Asn Thr Val Pro Gln Met 65 70 75 80 ctg gcg aac ctc ctg cat cca gcc aag ccc atc tcc ttt gct ggc tgc 288 Leu Ala Asn Leu Leu His Pro Ala Lys Pro Ile Ser Phe Ala Gly Cys 85 90 95 atg acg cag acc ttt ctc tgt ttg agt ttt gga cac agc gaa tgt ctc 336 Met Thr Gln Thr Phe Leu Cys Leu Ser Phe Gly His Ser Glu Cys Leu 100 105 110 ctg ctg gtg ctg atg tcc tac gat cgt tac gtg gcc atc tgc cac cct 384 Leu Leu Val Leu Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys His Pro 115 120 125 ctc cga tac tcc gtc atc atg acc tgg aga gtc tgc atc acc ctg gcc 432 Leu Arg Tyr Ser Val Ile Met Thr Trp Arg Val Cys Ile Thr Leu Ala 130 135 140 gtc act tcc tgg acg tgt ggc tcc ctc ctg gct ctg gcc cat gtg gtt 480 Val Thr Ser Trp Thr Cys Gly Ser Leu Leu Ala Leu Ala His Val Val 145 150 155 160 ctc atc cta aga ctg ccc ttc tct ggg cct cat gaa atc aac cac ttc 528 Leu Ile Leu Arg Leu Pro Phe Ser Gly Pro His Glu Ile Asn His Phe 165 170 175 ttc tgt gaa atc ctg tct gtc ctc agg ctg gcc tgt gct gac acc tgg 576 Phe Cys Glu Ile Leu Ser Val Leu Arg Leu Ala Cys Ala Asp Thr Trp 180 185 190 ctc aac cag gtg gtc atc ttt gca gcc tgc gtg ttc ttc ctg gtg ggg 624 Leu Asn Gln Val Val Ile Phe Ala Ala Cys Val Phe Phe Leu Val Gly 195 200 205 cca ccc agc ctg gtg ctt gtc tcc tac tcg cac atc ctg gcg gcc atc 672 Pro Pro Ser Leu Val Leu Val Ser Tyr Ser His Ile Leu Ala Ala Ile 210 215 220 c tg agg atc cag tct ggg gag ggc cgc aga aag gcc ttc tcc acc tgc 720 Leu Arg Ile Gln Ser Gly Glu Gly Arg Arg Lys Ala Phe Ser Thr Cys 225 230 235 240 tcc tcc cac ctc tgc gtg gtg gga ctc ttc ttt gca gtg cca tca tca 768 Ser Ser His Leu Cys Val Val Gly Leu Phe Phe Ala Val Pro Ser Ser 245 250 255 tgt aca tgg ccc cca agt ccc gcc atc ctg agg agc agc aaa agg tct 816 Cys Thr Trp Pro Pro Ser Pro Ala Ile Leu Arg Ser Ser Lys Arg Ser 260 265 270 ttt ttc tat ttt aca gtt ttt tca acc caa cac tta acc ccc tga 861 Phe Phe Tyr Phe Thr Val Phe Ser Thr Gln His Leu Thr Pro 275 280 285 <210> 598 <211> 286 <212> PRT <213> Homo sapiens <400> 598 Met Gly Glu Asn Gln Thr Met Val Thr Glu Phe Leu Leu Leu Gly Phe 1 5 10 15 Leu Leu Gly Pro Arg Ile Gln Met Leu Leu Phe Gly Leu Phe Ser Leu 20 25 30 Phe Tyr Ile Phe Thr Leu Leu Gly Asn Gly Ala Ile Leu Gly Leu Ile 35 40 45 Ser Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser His 50 55 60 Leu Ala Val Val Asp Ile Ala Tyr Thr Arg Asn Thr Val Pro Gln Met 65 70 75 80 Leu Ala Asn Leu Leu His Pro Ala Lys Pro Ile Ser Phe Ala Gly Cys 85 90 95 Met Thr Gln Thr Phe Leu Cys Leu Ser Phe Gly His Ser Glu Cys Leu 100 105 110 Leu Leu Val Leu Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys His Pro 115 120 125 Leu Arg Tyr Ser Val Ile Met Thr Trp Arg Val Cys Ile Thr Leu Ala 130 135 140 Val Thr Ser Trp Thr Cys Gly Ser Leu Leu Ala Leu Ala His Val Val 145 150 155 160 Leu Ile Leu Arg Leu Pro Phe Ser Gly Pro His Glu Ile Asn His Phe 165 170 175 Phe Cys Glu Ile Leu Ser Val Leu Arg Leu Ala Cys Ala Asp Thr Trp 180 185 190 Leu Asn Gln Val Val Ile Phe Ala Ala Cys Val Phe Phe Leu Val Gly 195 200 205 Pro Pro Ser Leu Val Leu Val Ser Tyr Ser His Ile Leu Ala Ala Ile 210 215 220 Leu Arg Ile Gln Ser Gly Glu Gly Arg Arg Lys Ala Phe Ser Thr Cys 225 230 235 240 Ser Ser His Leu Cys Val Val Gly Leu Phe Phe Ala Val Pro Ser Ser 245 250 255 Cys Thr Trp Pro Pro Ser Pro Ala Ile Leu Arg Ser Ser Lys Arg Ser 260 265 270 Phe Phe Tyr Phe Thr Val Phe Ser Thr Gln His Leu Thr Pro 275 280 285 <210> 599 <211> 945 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(945) <400> 599 atg ggg gat gtg aat cag tcg gtg gcc tca gac ttc att ctg gtg ggc 48 Met Gly Asp Val Asn Gln Ser Val Ala Ser Asp Phe Ile Leu Val Gly 1 5 10 15 ctc ttc agt cac tca gga tca cgc cag ctc ctc ttc tcc ctg gtg gct 96 Leu Phe Ser His Ser Gly Ser Arg Gln Leu Leu Phe Ser Leu Val Ala 20 25 30 gtc atg ttt gtc ata ggc ctt ctg ggc aac acc gtt ctt ctc ttc ttg 144 Val Met Phe Val Ile Gly Leu Leu Gly Asn Thr Val Leu Leu Phe Leu 35 40 45 atc cgt gtg gac tcc cgg ctc cac aca ccc atg tac ttc ctg ctc agc 192 Ile Arg Val Asp Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ser 50 55 60 cag ctc tcc ctg ttt gac att ggc tgt ccc atg gtc acc atc ccc aag 240 Gln Leu Ser Leu Phe Asp Ile Gly Cys Pro Met Val Thr Ile Pro Lys 65 70 75 80 atg gca tca gac ttt ctg cgg gga gaa ggt gcc acc tcc tat gga ggt 288 Met Ala Ser Asp Phe Leu Arg Gly Glu Gly Ala Thr Ser Tyr Gly Gly 85 90 95 ggt gca gct caa ata ttc ttc ctc aca ctg atg ggt gtg gct gag ggc 336 Gly Ala Ala Gln Ile Phe Phe Leu Thr Leu Met Gly Val Ala Glu Gly 100 105 110 gtc ctg ttg gtc ctc atg tct tat gac cgt tat gtt gct gtg tgc cag 384 Val Leu Leu Val Leu Met Ser Tyr Asp Arg Tyr Val Ala Val Cys Gln 115 120 125 ccc ctg cag tat cct gta ctt atg aga cgc cag gta tgt ctg ctg atg 432 Pro Leu Gln Tyr Pro Val Leu Met Arg Arg Gln Val Cys Leu Leu Met 130 135 140 atg ggc tcc tcc tgg gtg gta ggt gtg ctc aac gcc tcc atc cag acc 480 Met Gly Ser Ser Trp Val Val Gly Val Leu Asn Ala Ser Ile Gln Thr 145 150 155 160 tcc atc acc ctg cat ttt ccc tac tgt gcc tcc cgt att gtg gat cac 528 Ser Ile Thr Leu His Phe Pro Tyr Cys Ala Ser Arg Ile Val Asp His 165 170 175 ttc ttc tgt gag gtg cca gcc cta ctg aag ctc tcc tgt gca gat acc 576 Phe Phe Cys Glu Val Pro Ala Leu Leu Lys Leu Ser Cys Ala Asp Thr 180 185 190 tgt gcc tac gag atg gcg ctg tcc acc tca ggg gtg ctg atc cta atg 624 Cys Ala Tyr Glu Met Ala Leu Ser Thr Ser Gly Val Leu Ile Leu Met 195 200 205 ctc cct ctt tcc ctc atc gcc acc tcc tac ggc cac gtg ttg cag gct 672 Leu Pro Leu Ser Leu Ile Ala Thr Ser Tyr Gly His Val Leu Gln Ala 210 215 220 gtt cta agc atg cgc tca gag gag gcc aga cac aag gct gtc acc acc 720 Val Leu Ser Met Arg Ser Glu Glu Ala Arg His Lys Ala Val Thr Thr 225 230 235 240 tgc tcc tcg cac atc acg gta gtg ggg ctc ttt tat ggt gcc gcc gtg 768 Cys Ser Ser His Ile Thr Val Val Gly Leu Phe Tyr Gly Ala Ala Val 245 250 255 ttc atg tac atg gtg cct tgc gcc tac cac agt cca cag cag gat aac 816 Phe Met Tyr Met Val Pro Cys Ala Tyr His Ser Pro Gln Gln Asp Asn 260 265 270 gtg gtt tcc ctc ttc tat agc ctt gtc acc cct aca ctc aac ccc ctt 864 Val Val Ser Leu Phe Tyr Ser Leu Val Thr Pro Thr Leu Asn Pro Leu 275 280 285 atc tac agt ctg agg aat ccg gag gtg tgg atg gct ttg gtc aaa gtg 912 Ile Tyr Ser Leu Arg Asn Pro Glu Val Trp Met Ala Leu Val Lys Val 290 295 300 ctt agc aga gct gga ctc agg caa atg tgc tga 945 Leu Ser Arg Ala Gly Leu Arg Gln Met Cys 305 310 315 <210> 600 <211> 314 <212> PRT <213> Homo sapiens <400> 600 Met Gly Asp Val Asn Gln Ser Val Ala Ser Asp Phe Ile Leu Val Gly 1 5 10 15 Leu Phe Ser His Ser Gly Ser Arg Gln Leu Leu Phe Ser Leu Val Ala 20 25 30 Val Met Phe Val Ile Gly Leu Leu Gly Asn Thr Val Leu Leu Phe Leu 35 40 45 Ile Arg Val Asp Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ser 50 55 60 Gln Leu Ser Leu Phe Asp Ile Gly Cys Pro Met Val Thr Ile Pro Lys 65 70 75 80 Met Ala Ser Asp Phe Leu Arg Gly Glu Gly Ala Thr Ser Tyr Gly Gly 85 90 95 Gly Ala Ala Gln Ile Phe Phe Leu Thr Leu Met Gly Val Ala Glu Gly 100 105 110 Val Leu Leu Val Leu Met Ser Tyr Asp Arg Tyr Val Ala Val Cys Gln 115 120 125 Pro Leu Gln Tyr Pro Val Leu Met Arg Arg Gln Val Cys Leu Leu Met 130 135 140 Met Gly Ser Ser Trp Val Val Gly Val Leu Asn Ala Ser Ile Gln Thr 145 150 155 160 Ser Ile Thr Leu His Phe Pro Tyr Cys Ala Ser Arg Ile Val Asp His 165 170 175 Phe Phe Cys Glu Val Pro Ala Leu Leu Lys Leu Ser Cys Ala Asp Thr 180 185 190 Cys Ala Tyr Glu Met Ala Leu Ser Thr Ser Gly Val Leu Ile Leu Met 195 200 205 Leu Pro Leu Ser Leu Ile Ala Thr Ser Tyr Gly His Val Leu Gln Ala 210 215 220 Val Leu Ser Met Arg Ser Glu Glu Ala Arg His Lys Ala Val Thr Thr 225 230 235 240 Cys Ser Ser His Ile Thr Val Val Gly Leu Phe Tyr Gly Ala Ala Val 245 250 255 Phe Met Tyr Met Val Pro Cys Ala Tyr His Ser Pro Gln Gln Asp Asn 260 265 270 Val Val Ser Leu Phe Tyr Ser Leu Val Thr Pro Thr Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Pro Glu Val Trp Met Ala Leu Val Lys Val 290 295 300 Leu Ser Arg Ala Gly Leu Arg Gln Met Cys 305 310 <210> 601 <211> 948 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(948) <400> 601 atg cag ggg cta aac cac acc tcc gtg tct gaa ttc atc ctc gtt ggc 48 Met Gln Gly Leu Asn His Thr Ser Val Ser Glu Phe Ile Leu Val Gly 1 5 10 15 ttc tct gcc ttc ccc cac ctc cag ctg atg ctc ttc ctg ctg ttc ctg 96 Phe Ser Ala Phe Pro His Leu Gln Leu Met Leu Phe Leu Leu Phe Leu 20 25 30 ctg atg tac ctg ttc acg ctg ctg ggc aac ctg ctc atc atg gcc act 144 Leu Met Tyr Leu Phe Thr Leu Leu Gly Asn Leu Leu Ile Met Ala Thr 35 40 45 gtc tgg agc gag cgc agc ctc cac atg ccc atg tac ctc ttc ctg tgt 192 Val Trp Ser Glu Arg Ser Leu His Met Pro Met Tyr Leu Phe Leu Cys 50 55 60 gcc ctc tcc atc acc gag atc ctc tac acc gtg gcc atc atc ccg cgc 240 Ala Leu Ser Ile Thr Glu Ile Leu Tyr Thr Val Ala Ile Ile Pro Arg 65 70 75 80 atg ctg gcc gac ctg ctg tcc acc cag cgc tcc atc gcc ttc ctg gcc 288 Met Leu Ala Asp Leu Leu Ser Thr Gln Arg Ser Ile Ala Phe Leu Ala 85 90 95 tgt gcc agt cag atg ttc ttc tcc ttc agc ttc ggc ttc acc cac tcc 336 Cys Ala Ser Gln Met Phe Phe Ser Phe Ser Phe Gly Phe Thr His Ser 100 105 110 ttc ctg ctc act gtc atg ggc tac gac cgc tac gtg gcc atc tgc cac 384 Phe Leu Leu Thr Val Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 ccc ctg cgt tac aac gtg ctc atg agc ctg cgg ggc tgc acc tgc cgg 432 Pro Leu Arg Tyr Asn Val Leu Met Ser Leu Arg Gly Cys Thr Cys Arg 130 135 140 gtg ggc tgc tcc tgg gct ggt ggc ttg gtc atg ggg atg gtg gtg acc 480 Val Gly Cys Ser Trp Ala Gly Gly Leu Val Met Gly Met Val Val Thr 145 150 155 160 tcg gcc att ttc cac ctc gcc ttc tgt gga cac aag gag atc cac cat 528 Ser Ala Ile Phe His Leu Ala Phe Cys Gly His Lys Glu Ile His His 165 170 175 ttc ttc tgc cac gtg cca cct ctg ttg aag ttg gcc tgt gga gat gat 576 Phe Phe Cys His Val Pro Pro Leu Leu Lys Leu Ala Cys Gly Asp Asp 180 185 190 gtg ctg gtg gtg gcc aaa ggc gtg ggc ttg gtg tgt atc acg gcc ctg 624 Val Leu Val Val Ala Lys Gly Val Gly Leu Val Cys Ile Thr Ala Leu 195 200 205 ctg ggc tgt ttt ctc ctc atc ctc ctc tcc tat gcc ttc atc gtg gcc 672 Leu Gly Cys Phe Leu Leu Ile Leu Leu Ser Tyr Ala Phe Ile Val Ala 210 215 220 gcc atc ttg aag atc cct tct gct gaa ggt cgg aac aag gcc ttc tcc 720 Ala Ile Leu Lys Ile Pro Ser Ala Glu Gly Arg Asn Lys Ala Phe Ser 225 230 235 240 acc tgt gcc tct cac ctc act gtg gtg gtc gtg cac tat ggc ttt gcc 768 Thr Cys Ala Ser His Leu Thr Val Val Val Val His Tyr Gly Phe Ala 245 250 255 tcc gtc att tac ctg aag ccc aaa ggt ccc cag tct ccg gaa gga gac 816 Ser Val Ile Tyr Leu Lys Pro Lys Gly Pro Gln Ser Pro Glu Gly Asp 260 265 270 acc ttg atg ggc atc acc tac acg gtc ctc aca ccc ttc ctc agc ccc 864 Thr Leu Met Gly Ile Thr Tyr Thr Val Leu Thr Pro Phe Leu Ser Pro 275 280 285 atc atc ttc agc ctc agg aac aag gag ctg aag gtc gcc atg aag aag 912 Ile Ile Phe Ser Leu Arg Asn Lys Glu Leu Lys Val Ala Met Lys Lys 290 295 300 act tgc ttc acc aaa ctc ttt cca cag aac tgc tga 948 Thr Cys Phe Thr Lys Leu Phe Pro Gln Asn Cys 305 310 315 <210> 602 <211> 315 <212> PRT <213> Homo sapiens <400> 602 Met Gln Gly Leu Asn His Thr Ser Val Ser Glu Phe Ile Leu Val Gly 1 5 10 15 Phe Ser Ala Phe Pro His Leu Gln Leu Met Leu Phe Leu Leu Phe Leu 20 25 30 Leu Met Tyr Leu Phe Thr Leu Leu Gly Asn Leu Leu Ile Met Ala Thr 35 40 45 Val Trp Ser Glu Arg Ser Leu His Met Pro Met Tyr Leu Phe Leu Cys 50 55 60 Ala Leu Ser Ile Thr Glu Ile Leu Tyr Thr Val Ala Ile Ile Pro Arg 65 70 75 80 Met Leu Ala Asp Leu Leu Ser Thr Gln Arg Ser Ile Ala Phe Leu Ala 85 90 95 Cys Ala Ser Gln Met Phe Phe Ser Phe Ser Phe Gly Phe Thr His Ser 100 105 110 Phe Leu Leu Thr Val Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu Arg Tyr Asn Val Leu Met Ser Leu Arg Gly Cys Thr Cys Arg 130 135 140 Val Gly Cys Ser Trp Ala Gly Gly Leu Val Met Gly Met Val Val Thr 145 150 155 160 Ser Ala Ile Phe His Leu Ala Phe Cys Gly His Lys Glu Ile His His 165 170 175 Phe Phe Cys His Val Pro Pro Leu Leu Lys Leu Ala Cys Gly Asp Asp 180 185 190 Val Leu Val Val Ala Lys Gly Val Gly Leu Val Cys Ile Thr Ala Leu 195 200 205 Leu Gly Cys Phe Leu Leu Ile Leu Leu Ser Tyr Ala Phe Ile Val Ala 210 215 220 Ala Ile Leu Lys Ile Pro Ser Ala Glu Gly Arg Asn Lys Ala Phe Ser 225 230 235 240 Thr Cys Ala Ser His Leu Thr Val Val Val Val His Tyr Gly Phe Ala 245 250 255 Ser Val Ile Tyr Leu Lys Pro Lys Gly Pro Gln Ser Pro Glu Gly Asp 260 265 270 Thr Leu Met Gly Ile Thr Tyr Thr Val Leu Thr Pro Phe Leu Ser Pro 275 280 285 Ile Ile Phe Ser Leu Arg Asn Lys Glu Leu Lys Val Ala Met Lys Lys 290 295 300 Thr Cys Phe Thr Lys Leu Phe Pro Gln Asn Cys 305 310 315 <210> 603 <211> 1089 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1089) <400> 603 atg aca gag ttt cat ctg caa agc caa atg ccc tca ata aga ctc atc 48 Met Thr Glu Phe His Leu Gln Ser Gln Met Pro Ser Ile Arg Leu Ile 1 5 10 15 ttc aga agg ctg tcc tta ggc aga att aaa ccc agt cag agc ccc agg 96 Phe Arg Arg Leu Ser Leu Gly Arg Ile Lys Pro Ser Gln Ser Pro Arg 20 25 30 tgt tca acc tca ttt atg gtg gtg cct tct ttc tcc atc gca gag cac 144 Cys Ser Thr Ser Phe Met Val Val Pro Ser Phe Ser Ile Ala Glu His 35 40 45 tgg aga agg atg aaa ggg gca aac ctg agc caa ggg atg gag ttt gag 192 Trp Arg Arg Met Lys Gly Ala Asn Leu Ser Gln Gly Met Glu Phe Glu 50 55 60 ctc ttg ggc ctc acc act gac ccc cag ctc cag agg ctg ctc ttc gtg 240 Leu Leu Gly Leu Thr Thr Asp Pro Gln Leu Gln Arg Leu Leu Phe Val 65 70 75 80 gtg ttc ctg ggc atg tac aca gcc act ctg ctg ggg aac ctg gtc atg 288 Val Phe Leu Gly Met Tyr Thr Ala Thr Leu Leu Gly Asn Leu Val Met 85 90 95 ttc ctc ctg atc cat gtg agt gcc acc ctg cac aca ccc atg tac tcc 336 Phe Leu Leu Ile His Val Ser Ala Thr Leu His Thr Pro Met Tyr Ser 100 105 110 ctc ctg aag agc ctc tcc ttc ttg gat ttc tgc tac tcc tcc acg gtt 384 Leu Leu Lys Ser Leu Ser Phe Leu Asp Phe Cys Tyr Ser Ser Thr Val 115 120 125 gtg ccc cag acc ctg gtg aac ttc ttg gcc aag agg aaa gtg atc tct 432 Val Pro Gln Thr Leu Val Asn Phe Leu Ala Lys Arg Lys Val Ile Ser 130 135 140 tat ttt ggc tgc atg act cag atg ttc ttc tat gcg ggt ttt gcc acc 480 Tyr Phe Gly Cys Met Thr Gln Met Phe Phe Tyr Ala Gly Phe Ala Thr 145 150 155 160 agt gag tgc tat ctc atc gct gcc atg gcc tat gac cgc tat gcc gct 528 Ser Glu Cys Tyr Leu Ile Ala Ala Met Ala Tyr Asp Arg Tyr Ala Ala 165 170 175 att tgt aac ccc ctg ctc tac tca acc atc atg tct cct gag gtc tgt 576 Ile Cys Asn Pro Leu Leu Tyr Ser Thr Ile Met Ser Pro Glu Val Cys 180 185 190 gcc tcg ctg att gtg ggc tcc tac agt gca gga ttc ctc aat tct ctt 624 Ala Ser Leu Ile Val Gly Ser Tyr Ser Ala Gly Phe Leu Asn Ser Leu 195 200 205 atc cac act ggc tgt atc ttt agt ctg aaa ttc tgc ggt gct cat gtc 672 Ile His Thr Gly Cys Ile Phe Ser Leu Lys Phe Cys Gly Ala His Val 210 215 220 gtc act cac ttc ttc tgt gat ggg cca ccc atc ctg tcc ttg tct tgt 720 Val Thr His Phe Phe Cys Asp Gly Pro Pro Ile Leu Ser Leu Ser Cys 225 230 235 240 gta gac acc tca ctg tgt gag atc ctg ctc ttc att ttt gct ggt ttc 768 Val Asp Thr Ser Leu Cys Glu Ile Leu Leu Phe Ile Phe Ala Gly Phe 245 250 255 aac ctt ttg agc tgc acc ctc acc atc ttg atc tcc tac ttc tta att 816 Asn Leu Leu Ser Cys Thr Leu Thr Ile Leu Ile Ser Tyr Phe Leu Ile 260 265 270 ctc aac acc atc ctg aaa atg agc tcg gcc cag ggc agg ttt aag gca 864 Leu Asn Thr Ile Leu Lys Met Ser Ser Ala Gln Gly Arg Phe Lys Ala 275 280 285 ttt tcc acc tgt gca tcc cac ctc act gcc atc tgc ctc ttc ttt ggc 912 Phe Ser Thr Cys Ala Ser His Leu Thr Ala Ile Cys Leu Phe Phe Gly 290 295 300 aca aca ctt ttt atg tac ctg cgc ccc agg tcc agc tac tcc ttg acc 960 Thr Thr Leu Phe Met Tyr Leu Arg Pro Arg Ser Ser Tyr Ser Leu Thr 305 310 315 320 cag gac cgc aca gtt gct gtc atc tac aca gtg gtg atc cca gtg ctg 1008 Gln Asp Arg Thr Val Ala Val Ile Tyr Thr Val Val Ile Pro Val Leu 325 330 335 aac ccc ctc atg tac tct ttg aga aac aag gat gtg aag aaa gct tta 1056 Asn Pro Leu Met Tyr Ser Leu Arg Asn Lys Asp Val Lys Lys Ala Leu 340 345 350 ata aag gtt tgg ggt agg aaa aca atg gaa tga 1089 Ile Lys Val Trp Gly Arg Lys Thr Met Glu 355 360 <210> 604 <211> 362 <212> PRT <213> Homo sapiens <400> 604 Met Thr Glu Phe His Leu Gln Ser Gln Met Pro Ser Ile Arg Leu Ile 1 5 10 15 Phe Arg Arg Leu Ser Leu Gly Arg Ile Lys Pro Ser Gln Ser Pro Arg 20 25 30 Cys Ser Thr Ser Phe Met Val Val Pro Ser Phe Ser Ile Ala Glu His 35 40 45 Trp Arg Arg Met Lys Gly Ala Asn Leu Ser Gln Gly Met Glu Phe Glu 50 55 60 Leu Leu Gly Leu Thr Thr Asp Pro Gln Leu Gln Arg Leu Leu Phe Val 65 70 75 80 Val Phe Leu Gly Met Tyr Thr Ala Thr Leu Leu Gly Asn Leu Val Met 85 90 95 Phe Leu Leu Ile His Val Ser Ala Thr Leu His Thr Pro Met Tyr Ser 100 105 110 Leu Leu Lys Ser Leu Ser Phe Leu Asp Phe Cys Tyr Ser Ser Thr Val 115 120 125 Val Pro Gln Thr Leu Val Asn Phe Leu Ala Lys Arg Lys Val Ile Ser 130 135 140 Tyr Phe Gly Cys Met Thr Gln Met Phe Phe Tyr Ala Gly Phe Ala Thr 145 150 155 160 Ser Glu Cys Tyr Leu Ile Ala Ala Met Ala Tyr Asp Arg Tyr Ala Ala 165 170 175 Ile Cys Asn Pro Leu Leu Tyr Ser Thr Ile Met Ser Pro Glu Val Cys 180 185 190 Ala Ser Leu Ile Val Gly Ser Tyr Ser Ala Gly Phe Leu Asn Ser Leu 195 200 205 Ile His Thr Gly Cys Ile Phe Ser Leu Lys Phe Cys Gly Ala His Val 210 215 220 Val Thr His Phe Phe Cys Asp Gly Pro Pro Ile Leu Ser Leu Ser Cys 225 230 235 240 Val Asp Thr Ser Leu Cys Glu Ile Leu Leu Phe Ile Phe Ala Gly Phe 245 250 255 Asn Leu Leu Ser Cys Thr Leu Thr Ile Leu Ile Ser Tyr Phe Leu Ile 260 265 270 Leu Asn Thr Ile Leu Lys Met Ser Ser Ala Gln Gly Arg Phe Lys Ala 275 280 285 Phe Ser Thr Cys Ala Ser His Leu Thr Ala Ile Cys Leu Phe Phe Gly 290 295 300 Thr Thr Leu Phe Met Tyr Leu Arg Pro Arg Ser Ser Tyr Ser Leu Thr 305 310 315 320 Gln Asp Arg Thr Val Ala Val Ile Tyr Thr Val Val Ile Pro Val Leu 325 330 335 Asn Pro Leu Met Tyr Ser Leu Arg Asn Lys Asp Val Lys Lys Ala Leu 340 345 350 Ile Lys Val Trp Gly Arg Lys Thr Met Glu 355 360 <210> 605 <211> 993 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(993) <400> 605 atg ttc ttt att att cat tct ttg gtt act tct gtt ttt cta aca gct 48 Met Phe Phe Ile Ile His Ser Leu Val Thr Ser Val Phe Leu Thr Ala 1 5 10 15 ttg gga ccc cag aac aga aca atg cat ttt gtg act gag ttt gtc ctc 96 Leu Gly Pro Gln Asn Arg Thr Met His Phe Val Thr Glu Phe Val Leu 20 25 30 ctg ggt ttc cat ggt caa agg gag atg cag agc tgc ttc ttc tca ttc 144 Leu Gly Phe His Gly Gln Arg Glu Met Gln Ser Cys Phe Phe Ser Phe 35 40 45 atc ctg gtt ctc tat ctc ctg aca ctg cta ggg aat gga gct att gtc 192 Ile Leu Val Leu Tyr Leu Leu Thr Leu Leu Gly Asn Gly Ala Ile Val 50 55 60 tgt gca gtg aaa ttg gac agg cgg ctc cac aca ccc atg tac atc ctt 240 Cys Ala Val Lys Leu Asp Arg Arg Leu His Thr Pro Met Tyr Ile Leu 65 70 75 80 ctg gga aac ttt gcc ttt cta gag atc tgg tac att tcc tcc act gtc 288 Leu Gly Asn Phe Ala Phe Leu Glu Ile Trp Tyr Ile Ser Ser Thr Val 85 90 95 cca aac atg cta gtc aat atc ctc tct gag att aaa acc atc tcc ttc 336 Pro Asn Met Leu Val Asn Ile Leu Ser Glu Ile Lys Thr Ile Ser Phe 100 105 110 tct ggt tgc ttc ctg caa ttc tat ttc ttt ttt tca ctg ggt aca aca 384 Ser Gly Cys Phe Leu Gln Phe Tyr Phe Phe Phe Ser Leu Gly Thr Thr 115 120 125 gag tgt ttc ttt tta tca gtt atg gct tat gat cgg tac ctg gcc atc 432 Glu Cys Phe Phe Leu Ser Val Met Ala Tyr Asp Arg Tyr Leu Ala Ile 130 135 140 tgt cgt cca tta cac tac ccc tcc atc atg act ggg aag ttc tgt ata 480 Cys Arg Pro Leu His Tyr Pro Ser Ile Met Thr Gly Lys Phe Cys Ile 145 150 155 160 att ctg gtc tgt gta tgc tgg gta ggc gga ttt ctc tgc tat cca gtc 528 Ile Leu Val Cys Val Cys Trp Val Gly Gly Phe Leu Cys Tyr Pro Val 165 170 175 cct att gtt ctt atc tcc caa ctt ccc ttc tgt ggg ccc aac atc att 576 Pro Ile Val Leu Ile Ser Gln Leu Pro Phe Cys Gly Pro Asn Ile Ile 180 185 190 gac cac ttg gtg tgt gac cca ggc cca ttg ttt gca ctg gcc tgc atc 624 Asp His Leu Val Cys Asp Pro Gly Pro Leu Phe Ala Leu Ala Cys Ile 195 200 205 tct gct cct tcc act gag ctt atc tgt tac acc ttc aac tcg atg att 672 Ser Ala Pro Ser Thr Glu Leu Ile Cys Tyr Thr Phe Asn Ser Met Ile 210 215 220 atc ttt ggg ccc ttc ctc tcc atc ttg gga tct tac act ctg gtc atc 720 Ile Phe Gly Pro Phe Leu Ser Ile Leu Gly Ser Tyr Thr Leu Val Ile 225 230 235 240 aga gct gtg ctt tgt att ccc tct ggt gct ggt cga act aaa gct ttc 768 Arg Ala Val Leu Cys Ile Pro Ser Gly Ala Gly Arg Thr Lys Ala Phe 245 250 255 tcc aca tgt ggg tcc cac cta atg gtg gtg tct cta ttc tat gga acc 816 Ser Thr Cys Gly Ser His Leu Met Val Val Ser Leu Phe Tyr Gly Thr 260 265 270 ctt atg gtg atg tat gtg agc cca aca tca ggg aac cca gca gga atg 864 Leu Met Val Met Tyr Val Ser Pro Thr Ser Gly Asn Pro Ala Gly Met 275 280 285 cag aag atc atc act ctg gta tac aca gca atg act cca ttc tta aat 912 Gln Lys Ile Ile Thr Leu Val Tyr Thr Ala Met Thr Pro Phe Leu Asn 290 295 300 ccc ctt atc tat agt ctt cga aac aaa gac atg aaa gat gct cta aag 960 Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys Asp Ala Leu Lys 305 310 315 320 aga gtc ctg ggg tta aca gtt agc caa aac tga 993 Arg Val Leu Gly Leu Thr Val Ser Gln Asn 325 330 <210> 606 <211> 330 <212> PRT <213> Homo sapiens <400> 606 Met Phe Phe Ile Ile His Ser Leu Val Thr Ser Val Phe Leu Thr Ala 1 5 10 15 Leu Gly Pro Gln Asn Arg Thr Met His Phe Val Thr Glu Phe Val Leu 20 25 30 Leu Gly Phe His Gly Gln Arg Glu Met Gln Ser Cys Phe Phe Ser Phe 35 40 45 Ile Leu Val Leu Tyr Leu Leu Thr Leu Leu Gly Asn Gly Ala Ile Val 50 55 60 Cys Ala Val Lys Leu Asp Arg Arg Leu His Thr Pro Met Tyr Ile Leu 65 70 75 80 Leu Gly Asn Phe Ala Phe Leu Glu Ile Trp Tyr Ile Ser Ser Thr Val 85 90 95 Pro Asn Met Leu Val Asn Ile Leu Ser Glu Ile Lys Thr Ile Ser Phe 100 105 110 Ser Gly Cys Phe Leu Gln Phe Tyr Phe Phe Phe Ser Leu Gly Thr Thr 115 120 125 Glu Cys Phe Phe Leu Ser Val Met Ala Tyr Asp Arg Tyr Leu Ala Ile 130 135 140 Cys Arg Pro Leu His Tyr Pro Ser Ile Met Thr Gly Lys Phe Cys Ile 145 150 155 160 Ile Leu Val Cys Val Cys Trp Val Gly Gly Phe Leu Cys Tyr Pro Val 165 170 175 Pro Ile Val Leu Ile Ser Gln Leu Pro Phe Cys Gly Pro Asn Ile Ile 180 185 190 Asp His Leu Val Cys Asp Pro Gly Pro Leu Phe Ala Leu Ala Cys Ile 195 200 205 Ser Ala Pro Ser Thr Glu Leu Ile Cys Tyr Thr Phe Asn Ser Met Ile 210 215 220 Ile Phe Gly Pro Phe Leu Ser Ile Leu Gly Ser Tyr Thr Leu Val Ile 225 230 235 240 Arg Ala Val Leu Cys Ile Pro Ser Gly Ala Gly Arg Thr Lys Ala Phe 245 250 255 Ser Thr Cys Gly Ser His Leu Met Val Val Ser Leu Phe Tyr Gly Thr 260 265 270 Leu Met Val Met Tyr Val Ser Pro Thr Ser Gly Asn Pro Ala Gly Met 275 280 285 Gln Lys Ile Ile Thr Leu Val Tyr Thr Ala Met Thr Pro Phe Leu Asn 290 295 300 Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys Asp Ala Leu Lys 305 310 315 320 Arg Val Leu Gly Leu Thr Val Ser Gln Asn 325 330 <210> 607 <211> 975 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(975) <400> 607 atg tct ttc ttc ttt gta gac tta aga ccc atg aac agg tca gca aca 48 Met Ser Phe Phe Phe Val Asp Leu Arg Pro Met Asn Arg Ser Ala Thr 1 5 10 15 cac atc gtg aca gag ttt att ctc ctg gga ttc cct ggt tgc tgg aag 96 His Ile Val Thr Glu Phe Ile Leu Leu Gly Phe Pro Gly Cys Trp Lys 20 25 30 att cag att ttc ctc ttc tca ttg ttt ttg gtg att tat gtc ttg acc 144 Ile Gln Ile Phe Leu Phe Ser Leu Phe Leu Val Ile Tyr Val Leu Thr 35 40 45 ttg ctg gga aat gga gcc atc atc tat gca gtg aga tgc aac cca cta 192 Leu Leu Gly Asn Gly Ala Ile Ile Tyr Ala Val Arg Cys Asn Pro Leu 50 55 60 cta cac acc ccc atg tac ttt ctg ctg gga aat ttt gcc ttc ctt gag 240 Leu His Thr Pro Met Tyr Phe Leu Leu Gly Asn Phe Ala Phe Leu Glu 65 70 75 80 atc tgg tat gtg tcc tcc act att cct aac atg cta gtc aac att ctc 288 Ile Trp Tyr Val Ser Ser Thr Ile Pro Asn Met Leu Val Asn Ile Leu 85 90 95 tcc aag acc aag gcc atc tca ttt tct ggg tgc ttc ctc cag ttc tat 336 Ser Lys Thr Lys Ala Ile Ser Phe Ser Gly Cys Phe Leu Gln Phe Tyr 100 105 110 ttc ttc ttt tca ctg gga aca act gaa tgt ctc ttt ctg gca gta atg 384 Phe Phe Phe Ser Leu Gly Thr Thr Glu Cys Leu Phe Leu Ala Val Met 115 120 125 gct tat gat cga tac ctg gcc atc tgc cac cca ctg cag tac cct gcc 432 Ala Tyr Asp Arg Tyr Leu Ala Ile Cys His Pro Leu Gln Tyr Pro Ala 130 135 140 atc atg act gta agg ttc tgt ggt aag ctg gtg tct ttc tgt tgg ctt 480 Ile Met Thr Val Arg Phe Cys Gly Lys Leu Val Ser Phe Cys Trp Leu 145 150 155 160 att gga ttc ctt gga tac cca att ccc att ttc tac atc tcc caa ctc 528 Ile Gly Phe Leu Gly Tyr Pro Ile Pro Ile Phe Tyr Ile Ser Gln Leu 165 170 175 ccc ttc tgt ggt cct aat atc att gat cac ttc ctg tgt gac atg gac 576 Pro Phe Cys Gly Pro Asn Ile Ile Asp His Phe Leu Cys Asp Met Asp 180 185 190 cca ttg atg gct cta tcc tgt gcc cca gct ccc ata act gaa tgt att 624 Pro Leu Met Ala Leu Ser Cys Ala Pro Ala Pro Ile Thr Glu Cys Ile 195 200 205 ttc tat act cag agc tcc ctt gtc ctc ttt ttc act agt atg tac att 672 Phe Tyr Thr Gln Ser Ser Leu Val Leu Phe Phe Thr Ser Met Tyr Ile 210 215 220 ctt cga tcc tat atc ctg tta cta aca gct gtt ttt cag gtc cct tct 720 Leu Arg Ser Tyr Ile Leu Leu Leu Thr Ala Val Phe Gln Val Pro Ser 225 230 235 240 gca gct ggt cgg aga aaa gcc ttc tct acc tgt ggt tct cat ttg gtt 768 Ala Ala Gly Arg Arg Lys Ala Phe Ser Thr Cys Gly Ser His Leu Val 245 250 255 gtg gta tct ctt ttc tat ggg aca gtc atg gta atg tat gta agt cct 816 Val Val Ser Leu Phe Tyr Gly Thr Val Met Val Met Tyr Val Ser Pro 260 265 270 aca tat ggg atc cca act tta ttg cag aag atc ctc aca ctg gta tat 864 Thr Tyr Gly Ile Pro Thr Leu Leu Gln Lys Ile Leu Thr Leu Val Tyr 275 280 285 tca gta acg act cct ctt ttt aat cct ctg atc tat act ctt cgt aat 912 Ser Val Thr Thr Pro Leu Phe Asn Pro Leu Ile Tyr Thr Leu Arg Asn 290 295 300 aag gac atg aaa ctc gct ctg aga aat gtc ctg ttt gga atg aga att 960 Lys Asp Met Lys Leu Ala Leu Arg Asn Val Leu Phe Gly Met Arg Ile 305 310 315 320 cgt caa aat tcg tga 975 Arg Gln Asn Ser 325 <210> 608 <211> 324 <212> PRT <213> Homo sapiens <400> 608 Met Ser Phe Phe Phe Val Asp Leu Arg Pro Met Asn Arg Ser Ala Thr 1 5 10 15 His Ile Val Thr Glu Phe Ile Leu Leu Gly Phe Pro Gly Cys Trp Lys 20 25 30 Ile Gln Ile Phe Leu Phe Ser Leu Phe Leu Val Ile Tyr Val Leu Thr 35 40 45 Leu Leu Gly Asn Gly Ala Ile Ile Tyr Ala Val Arg Cys Asn Pro Leu 50 55 60 Leu His Thr Pro Met Tyr Phe Leu Leu Gly Asn Phe Ala Phe Leu Glu 65 70 75 80 Ile Trp Tyr Val Ser Ser Thr Ile Pro Asn Met Leu Val Asn Ile Leu 85 90 95 Ser Lys Thr Lys Ala Ile Ser Phe Ser Gly Cys Phe Leu Gln Phe Tyr 100 105 110 Phe Phe Phe Ser Leu Gly Thr Thr Glu Cys Leu Phe Leu Ala Val Met 115 120 125 Ala Tyr Asp Arg Tyr Leu Ala Ile Cys His Pro Leu Gln Tyr Pro Ala 130 135 140 Ile Met Thr Val Arg Phe Cys Gly Lys Leu Val Ser Phe Cys Trp Leu 145 150 155 160 Ile Gly Phe Leu Gly Tyr Pro Ile Pro Ile Phe Tyr Ile Ser Gln Leu 165 170 175 Pro Phe Cys Gly Pro Asn Ile Ile Asp His Phe Leu Cys Asp Met Asp 180 185 190 Pro Leu Met Ala Leu Ser Cys Ala Pro Ala Pro Ile Thr Glu Cys Ile 195 200 205 Phe Tyr Thr Gln Ser Ser Leu Val Leu Phe Phe Thr Ser Met Tyr Ile 210 215 220 Leu Arg Ser Tyr Ile Leu Leu Leu Thr Ala Val Phe Gln Val Pro Ser 225 230 235 240 Ala Ala Gly Arg Arg Lys Ala Phe Ser Thr Cys Gly Ser His Leu Val 245 250 255 Val Val Ser Leu Phe Tyr Gly Thr Val Met Val Met Tyr Val Ser Pro 260 265 270 Thr Tyr Gly Ile Pro Thr Leu Leu Gln Lys Ile Leu Thr Leu Val Tyr 275 280 285 Ser Val Thr Thr Pro Leu Phe Asn Pro Leu Ile Tyr Thr Leu Arg Asn 290 295 300 Lys Asp Met Lys Leu Ala Leu Arg Asn Val Leu Phe Gly Met Arg Ile 305 310 315 320 Arg Gln Asn Ser <210> 609 <211> 927 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(927) <400> 609 atg gaa aca cag aac ctc aca gtg gtg aca gaa ttc att ctt ctt ggt 48 Met Glu Thr Gln Asn Leu Thr Val Val Thr Glu Phe Ile Leu Leu Gly 1 5 10 15 ctg acc cag tct caa gat gct caa ctt ctg gtc ttt gtg cta gtc tta 96 Leu Thr Gln Ser Gln Asp Ala Gln Leu Leu Val Phe Val Leu Val Leu 20 25 30 att ttc tac ctt atc atc ctc cct gga aat ttc ctc atc att ttc acc 144 Ile Phe Tyr Leu Ile Ile Leu Pro Gly Asn Phe Leu Ile Ile Phe Thr 35 40 45 ata aag tca gac cct ggg ctc aca gcc ccc ctc tat ttc ttt ctg ggc 192 Ile Lys Ser Asp Pro Gly Leu Thr Ala Pro Leu Tyr Phe Phe Leu Gly 50 55 60 aac ttg gcc tta ctg gat gca tcc tac tcc ttc att gtg gtt ccc agg 240 Asn Leu Ala Leu Leu Asp Ala Ser Tyr Ser Phe Ile Val Val Pro Arg 65 70 75 80 atg ttg gtg gac ttc ctc tct gag aag aag gta atc tcc tat aga agc 288 Met Leu Val Asp Phe Leu Ser Glu Lys Lys Val Ile Ser Tyr Arg Ser 85 90 95 tgc atc act cag ctc ttt ttc ttg cat ttt ctt gga gcg gga gag atg 336 Cys Ile Thr Gln Leu Phe Phe Leu His Phe Leu Gly Ala Gly Glu Met 100 105 110 ttc ctc ctc gtt gtg atg gcc ttt gac cgc tac atc gcc atc tgc cgg 384 Phe Leu Leu Val Val Met Ala Phe Asp Arg Tyr Ile Ala Ile Cys Arg 115 120 125 cct tta cac tat tca acc atc atg aac cct aga gcc tgc tat gca tta 432 Pro Leu His Tyr Ser Thr Ile Met Asn Pro Arg Ala Cys Tyr Ala Leu 130 135 140 tcg ttg gtt ctg tgg ctt ggg ggc ttt atc cat tcc att gta caa gta 480 Ser Leu Val Leu Trp Leu Gly Gly Phe Ile His Ser Ile Val Gln Val 145 150 155 160 gcc ctt atc ctg cac ttg cct ttc tgt ggc cca aac cag ctc gat aac 528 Ala Leu Ile Leu His Leu Pro Phe Cys Gly Pro Asn Gln Leu Asp Asn 165 170 175 ttc ttc tgt gat gtt cca cag gtc atc aag ctg gcc tgc acc aat acc 576 Phe Phe Cys Asp Val Pro Gln Val Ile Lys Leu Ala Cys Thr Asn Thr 180 185 190 ttt gtg gtg gag ctt ctg atg gtc tcc aac agt ggc ctg ctc agc ctc 624 Phe Val Val Glu Leu Leu Met Val Ser Asn Ser Gly Leu Leu Ser Leu 195 200 205 ctg tgc ttc ctg ggc ctt ctg gcc tcc tat gca gtc atc ctc tgt cgt 672 Leu Cys Phe Leu Gly Leu Leu Ala Ser Tyr Ala Val Ile Leu Cys Arg 210 215 220 ata agg gag cac tcc tct gaa gga aag agc aag gct att tcc aca tgc 720 Ile Arg Glu His Ser Ser Glu Gly Lys Ser Lys Ala Ile Ser Thr Cys 225 230 235 240 acc acc cat att atc att ata ttt ctc atg ttt gga cct gct att ttc 768 Thr Thr His Ile Ile Ile Ile Phe Leu Met Phe Gly Pro Ala Ile Phe 245 250 255 atc tac act tgc ccc ttc cag gct ttc cca gct gac aag gta gtt tct 816 Ile Tyr Thr Cys Pro Phe Gln Ala Phe Pro Ala Asp Lys Val Val Ser 260 265 270 ctt ttc cat act gtc atc ttt cct ttg atg aac cct gtt att tat acg 864 Leu Phe His Thr Val Ile Phe Pro Leu Met Asn Pro Val Ile Tyr Thr 275 280 285 ctt cgc aac cag gag gtg aaa gct tcc atg agg aag ttg tta agt caa 912 Leu Arg Asn Gln Glu Val Lys Ala Ser Met Arg Lys Leu Leu Ser Gln 290 295 300 cat atg ttt tgc tga 927 His Met Phe Cys 305 <210> 610 <211> 308 <212> PRT <213> Homo sapiens <400> 610 Met Glu Thr Gln Asn Leu Thr Val Val Thr Glu Phe Ile Leu Leu Gly 1 5 10 15 Leu Thr Gln Ser Gln Asp Ala Gln Leu Leu Val Phe Val Leu Val Leu 20 25 30 Ile Phe Tyr Leu Ile Ile Leu Pro Gly Asn Phe Leu Ile Ile Phe Thr 35 40 45 Ile Lys Ser Asp Pro Gly Leu Thr Ala Pro Leu Tyr Phe Phe Leu Gly 50 55 60 Asn Leu Ala Leu Leu Asp Ala Ser Tyr Ser Phe Ile Val Val Pro Arg 65 70 75 80 Met Leu Val Asp Phe Leu Ser Glu Lys Lys Val Ile Ser Tyr Arg Ser 85 90 95 Cys Ile Thr Gln Leu Phe Phe Leu His Phe Leu Gly Ala Gly Glu Met 100 105 110 Phe Leu Leu Val Val Met Ala Phe Asp Arg Tyr Ile Ala Ile Cys Arg 115 120 125 Pro Leu His Tyr Ser Thr Ile Met Asn Pro Arg Ala Cys Tyr Ala Leu 130 135 140 Ser Leu Val Leu Trp Leu Gly Gly Phe Ile His Ser Ile Val Gln Val 145 150 155 160 Ala Leu Ile Leu His Leu Pro Phe Cys Gly Pro Asn Gln Leu Asp Asn 165 170 175 Phe Phe Cys Asp Val Pro Gln Val Ile Lys Leu Ala Cys Thr Asn Thr 180 185 190 Phe Val Val Glu Leu Leu Met Val Ser Asn Ser Gly Leu Leu Ser Leu 195 200 205 Leu Cys Phe Leu Gly Leu Leu Ala Ser Tyr Ala Val Ile Leu Cys Arg 210 215 220 Ile Arg Glu His Ser Ser Glu Gly Lys Ser Lys Ala Ile Ser Thr Cys 225 230 235 240 Thr Thr His Ile Ile Ile Ile Phe Leu Met Phe Gly Pro Ala Ile Phe 245 250 255 Ile Tyr Thr Cys Pro Phe Gln Ala Phe Pro Ala Asp Lys Val Val Ser 260 265 270 Leu Phe His Thr Val Ile Phe Pro Leu Met Asn Pro Val Ile Tyr Thr 275 280 285 Leu Arg Asn Gln Glu Val Lys Ala Ser Met Arg Lys Leu Leu Ser Gln 290 295 300 His Met Phe Cys 305 <210> 611 <211> 1038 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1038) <400> 611 atg cat ttt ctt tcc caa aat gat tta aat ata aat ctg att ccc cat 48 Met His Phe Leu Ser Gln Asn Asp Leu Asn Ile Asn Leu Ile Pro His 1 5 10 15 cta tgt ttg cac cgt cat tca gta att gct ggt gct ttt aca att cac 96 Leu Cys Leu His Arg His Ser Val Ile Ala Gly Ala Phe Thr Ile His 20 25 30 agg cac atg aaa atc ttc aac agc ccc agc aac tcc agc acc ttc act 144 Arg His Met Lys Ile Phe Asn Ser Pro Ser Asn Ser Ser Thr Phe Thr 35 40 45 ggc ttc atc ctc ctg ggc ttc cct tgc ccc agg gag ggg cag atc ctc 192 Gly Phe Ile Leu Leu Gly Phe Pro Cys Pro Arg Glu Gly Gln Ile Leu 50 55 60 ctc ttt gtg ctc ttc act gtt gtt tac ctc ctg acc ctc atg ggc aat 240 Leu Phe Val Leu Phe Thr Val Val Tyr Leu Leu Thr Leu Met Gly Asn 65 70 75 80 ggt tcc atc atc tgt gct gtg cac tgg gat cag aga ctc cac gcc ccc 288 Gly Ser Ile Ile Cys Ala Val His Trp Asp Gln Arg Leu His Ala Pro 85 90 95 atg tac atc ctg ctc gcc aac ttc tcc ttc ttg gag ata tgt tat gtc 336 Met Tyr Ile Leu Leu Ala Asn Phe Ser Phe Leu Glu Ile Cys Tyr Val 100 105 110 acc tcc aca gtc ccc agc atg ctg gcc aac ttc ctc tct gac acc aag 384 Thr Ser Thr Val Pro Ser Met Leu Ala Asn Phe Leu Ser Asp Thr Lys 115 120 125 atc atc tcg ttc tct ggc tgc ttc ctc cag ttc tac ttt ttc ttc tcc 432 Ile Ile Ser Phe Ser Gly Cys Phe Leu Gln Phe Tyr Phe Phe Phe Ser 130 135 140 ttg ggc tct aca gaa tgc ttt ttc ctg gca gtt atg gca ttt gat cga 480 Leu Gly Ser Thr Glu Cys Phe Phe Leu Ala Val Met Ala Phe Asp Arg 145 150 155 160 tac ctt gcc atc tgt cgg cct cta cgc tat cca acc att atg acc aga 528 Tyr Leu Ala Ile Cys Arg Pro Leu Arg Tyr Pro Thr Ile Met Thr Arg 165 170 175 cgt ctc tgt acc aat ctt gtg gtc aat tgc tgg gta ctt ggt ttc atc 576 Arg Leu Cys Thr Asn Leu Val Val Asn Cys Trp Val Leu Gly Phe Ile 180 185 190 tgg ttc ttg att cct atc gtc aac atc tcc caa atg tcc ttc tgt gga 624 Trp Phe Leu Ile Pro Ile Val Asn Ile Ser Gln Met Ser Phe Cys Gly 195 200 205 tct agg att att gac cac ttc cta tgt gac cca gct cct ctt cta act 672 Ser Arg Ile Ile Asp His Phe Leu Cys Asp Pro Ala Pro Leu Leu Thr 210 215 220 ctc act tgc aaa aaa ggc cct gtg ata gag ctt gtc ttt tct gtc tta 720 Leu Thr Cys Lys Lys Gly Pro Val Ile Glu Leu Val Phe Ser Val Leu 225 230 235 240 agt cct ctg cct gtc ttt atg ctc ttt ctc ttc att gtg ggg tcc tat 768 Ser Pro Leu Pro Val Phe Met Leu Phe Leu Phe Ile Val Gly Ser Tyr 245 250 255 gct ctg gtc gtg aga gct gtg ttg agg gtc cct tca gca gct ggg aga 816 Ala Leu Val Val Arg Ala Val Leu Arg Val Pro Ser Ala Ala Gly Arg 260 265 270 aga aag gct ttc tcc acc tgt ggg tct cac ctg gct gtg gtt tca ctg 864 Arg Lys Ala Phe Ser Thr Cys Gly Ser His Leu Ala Val Val Ser Leu 275 280 285 ttc tac ggc tca gta ctg gtc atg tat ggg agc cca cca tct aag aat 912 Phe Tyr Gly Ser Val Leu Val Met Tyr Gly Ser Pro Pro Ser Lys Asn 290 295 300 gaa gct gga aag cag aag act gtg act ctg ttt tat tct gtt gtt acc 960 Glu Ala Gly Lys Gln Lys Thr Val Thr Leu Phe Tyr Ser Val Val Thr 305 310 315 320 cca ctg ctt aac cct gtg ata tat agt ctt agg aac aaa gat atg aga 1008 Pro Leu Leu Asn Pro Val Ile Tyr Ser Leu Arg Asn Lys Asp Met Arg 325 330 335 aaa gct ctg aag aaa ttt tgg gga aca taa 1038 Lys Ala Leu Lys Lys Phe Trp Gly Thr 340 345 <210> 612 <211> 345 <212> PRT <213> Homo sapiens <400> 612 Met His Phe Leu Ser Gln Asn Asp Leu Asn Ile Asn Leu Ile Pro His 1 5 10 15 Leu Cys Leu His Arg His Ser Val Ile Ala Gly Ala Phe Thr Ile His 20 25 30 Arg His Met Lys Ile Phe Asn Ser Pro Ser Asn Ser Ser Thr Phe Thr 35 40 45 Gly Phe Ile Leu Leu Gly Phe Pro Cys Pro Arg Glu Gly Gln Ile Leu 50 55 60 Leu Phe Val Leu Phe Thr Val Val Tyr Leu Leu Thr Leu Met Gly Asn 65 70 75 80 Gly Ser Ile Ile Cys Ala Val His Trp Asp Gln Arg Leu His Ala Pro 85 90 95 Met Tyr Ile Leu Leu Ala Asn Phe Ser Phe Leu Glu Ile Cys Tyr Val 100 105 110 Thr Ser Thr Val Pro Ser Met Leu Ala Asn Phe Leu Ser Asp Thr Lys 115 120 125 Ile Ile Ser Phe Ser Gly Cys Phe Leu Gln Phe Tyr Phe Phe Phe Ser 130 135 140 Leu Gly Ser Thr Glu Cys Phe Phe Leu Ala Val Met Ala Phe Asp Arg 145 150 155 160 Tyr Leu Ala Ile Cys Arg Pro Leu Arg Tyr Pro Thr Ile Met Thr Arg 165 170 175 Arg Leu Cys Thr Asn Leu Val Val Asn Cys Trp Val Leu Gly Phe Ile 180 185 190 Trp Phe Leu Ile Pro Ile Val Asn Ile Ser Gln Met Ser Phe Cys Gly 195 200 205 Ser Arg Ile Ile Asp His Phe Leu Cys Asp Pro Ala Pro Leu Leu Thr 210 215 220 Leu Thr Cys Lys Lys Gly Pro Val Ile Glu Leu Val Phe Ser Val Leu 225 230 235 240 Ser Pro Leu Pro Val Phe Met Leu Phe Leu Phe Ile Val Gly Ser Tyr 245 250 255 Ala Leu Val Val Arg Ala Val Leu Arg Val Pro Ser Ala Ala Gly Arg 260 265 270 Arg Lys Ala Phe Ser Thr Cys Gly Ser His Leu Ala Val Val Ser Leu 275 280 285 Phe Tyr Gly Ser Val Leu Val Met Tyr Gly Ser Pro Pro Ser Lys Asn 290 295 300 Glu Ala Gly Lys Gln Lys Thr Val Thr Leu Phe Tyr Ser Val Val Thr 305 310 315 320 Pro Leu Leu Asn Pro Val Ile Tyr Ser Leu Arg Asn Lys Asp Met Arg 325 330 335 Lys Ala Leu Lys Lys Phe Trp Gly Thr 340 345 <210> 613 <211> 1044 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1044) <400> 613 atg ggt aac tgg act gca gcg gtg act gag ttt gtt ctg ctg ggg ttt 48 Me t Gly Asn Trp Thr Ala Ala Val Thr Glu Phe Val Leu Leu Gly Phe 1 5 10 15 tcc ctg agc agg gag gtg gag ctg ctg ctc ctg gtg ctc ctg ctg ccc 96 Ser Leu Ser Arg Glu Val Glu Leu Leu Leu Leu Val Leu Leu Leu Pro 20 25 30 acg ttc ctg ctg act ctt ctg ggg aac ctg ctc atc atc tcc act gtg 144 Thr Phe Leu Leu Thr Leu Leu Gly Asn Leu Leu Ile Ile Ser Thr Val 35 40 45 ctg tcc tgc tcc cgc ctc cac acc ccc atg tac ttc ttc ttg tgc aac 192 Leu Ser Cys Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Cys Asn 50 55 60 ctc tct atc ctg gac atc ctc ttc acc tca gtc atc tct cca aaa gtg 240 Leu Ser Ile Leu Asp Ile Leu Phe Thr Ser Val Ile Ser Pro Lys Val 65 70 75 80 ttg gcc aac tta gga tct agg gat aaa acc atc tcc ttt gcc gga tgt 288 Leu Ala Asn Leu Gly Ser Arg Asp Lys Thr Ile Ser Phe Ala Gly Cys 85 90 95 atc acc cag tgc tat ttc tac ttt ttc ttg ggc aca gtt gag ttc ctc 336 Ile Thr Gln Cys Tyr Phe Tyr Phe Phe Leu Gly Thr Val Glu Phe Leu 100 105 110 ctg ctg acg gtc atg tcc tat gac cgt tat gcc acc atc tgc tgc ccc 384 Leu Leu Thr Val Met Ser Tyr Asp Arg Tyr Ala Thr Ile Cys Cys Pro 115 120 125 ctg cgg tac acc acc atc atg aga cct tct gtc tgc att ggg acc gtt 432 Leu Arg Tyr Thr Thr Ile Met Arg Pro Ser Val Cys Ile Gly Thr Val 130 135 140 gta ttc tct tgg gtg gga ggc ttc ctg tct gtg ctc ttt cca acc atc 480 Val Phe Ser Trp Val Gly Gly Phe Leu Ser Val Leu Phe Pro Thr Ile 145 150 155 160 ctc atc tcc cag ctg ccc ttc tgt ggc tcc aat atc att aac cac ttc 528 Leu Ile Ser Gln Leu Pro Phe Cys Gly Ser Asn Ile Ile Asn His Phe 165 170 175 ttc tgt gac agt gga ccc ttg ctg gcc ctg gcc tgt gca gac acc act 576 Phe Cys Asp Ser Gly Pro Leu Leu Ala Leu Ala Cys Ala Asp Thr Thr 180 185 190 gcc atc gag ctg atg gat ttt atg ctt tct tcc atg gtc atc ctc tgc 624 Ala Ile Glu Leu Met Asp Phe Met Leu Ser Ser Met Val Ile Leu Cys 195 200 205 tgc ata gtc ctc gtg gcc tat tcc tat acg tac atc atc ttg acc ata 672 Cys Ile Val Leu Val Ala Tyr Ser Tyr Thr Tyr Ile Ile Leu Thr Ile 210 215 220 gtg cgc att cct tct gca agt gga agg aag aag gcc ttt aat acc tgt 720 Val Arg Ile Pro Ser Ala Ser Gly Arg Lys Lys Ala Phe Asn Thr Cys 225 230 235 240 gct tcc cac ctg acc ata gtc atc att cct agt ggc atc act gtg ttt 768 Ala Ser His Leu Thr Ile Val Ile Ile Pro Ser Gly Ile Thr Val Phe 245 250 255 atc tat gtg act ccc tcc cag aaa gaa tat ctg gag atc aac aag atc 816 Ile Tyr Val Thr Pro Ser Gln Lys Glu Tyr Leu Glu Ile Asn Lys Ile 260 265 270 cct ttg gtt ctg agc agt gtg gtg act cca ttc ctc aac ccc ttt ata 864 Pro Leu Val Leu Ser Ser Val Val Thr Pro Phe Leu Asn Pro Phe Ile 275 280 285 tat act ctg agg aat gac aca gtg cag gga gtc ctc agg gat gtg tgg 912 Tyr Thr Leu Arg Asn Asp Thr Val Gln Gly Val Leu Arg Asp Val Trp 290 295 300 gtc agg gtt cga gga gtt ttt gaa aag agg atg agg gca gtg ctg aga 960 Val Arg Val Arg Gly Val Phe Glu Lys Arg Met Arg Ala Val Leu Arg 305 310 315 320 agc aga tta tcc tcc aac aaa gac cac caa gga agg gct tgc tct tct 1008 Ser Arg Leu Ser Ser Asn Lys Asp His Gln Gly Arg Ala Cys Ser Ser 325 330 335 cca cca tgt gtc tat tct gta aag ctc cag tgt tag 1044 Pro Pro Cys Val Tyr Ser Val Lys Leu Gln Cys 340 345 <210> 614 <211> 347 <212> PRT <213> Homo sapiens <400> 614 Met Gly Asn Trp Thr Ala Ala Val Thr Glu Phe Val Leu Leu Gly Phe 1 5 10 15 Ser Leu Ser Arg Glu Val Glu Leu Leu Leu Leu Val Leu Leu Leu Pro 20 25 30 Thr Phe Leu Leu Thr Leu Leu Gly Asn Leu Leu Ile Ile Ser Thr Val 35 40 45 Leu Ser Cys Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Cys Asn 50 55 60 Leu Ser Ile Leu Asp Ile Leu Phe Thr Ser Val Ile Ser Pro Lys Val 65 70 75 80 Leu Ala Asn Leu Gly Ser Arg Asp Lys Thr Ile Ser Phe Ala Gly Cys 85 90 95 Ile Thr Gln Cys Tyr Phe Tyr Phe Phe Leu Gly Thr Val Glu Phe Leu 100 105 110 Leu Leu Thr Val Met Ser Tyr Asp Arg Tyr Ala Thr Ile Cys Cys Pro 115 120 125 Leu Arg Tyr Thr Thr Ile Met Arg Pro Ser Val Cys Ile Gly Thr Val 130 135 140 Val Phe Ser Trp Val Gly Gly Phe Leu Ser Val Leu Phe Pro Thr Ile 145 150 155 160 Leu Ile Ser Gln Leu Pro Phe Cys Gly Ser Asn Ile Ile Asn His Phe 165 170 175 Phe Cys Asp Ser Gly Pro Leu Leu Ala Leu Ala Cys Ala Asp Thr Thr 180 185 190 Ala Ile Glu Leu Met Asp Phe Met Leu Ser Ser Met Val Ile Leu Cys 195 200 205 Cys Ile Val Leu Val Ala Tyr Ser Tyr Thr Tyr Ile Ile Leu Thr Ile 210 215 220 Val Arg Ile Pro Ser Ala Ser Gly Arg Lys Lys Ala Phe Asn Thr Cys 225 230 235 240 Ala Ser His Leu Thr Ile Val Ile Ile Pro Ser Gly Ile Thr Val Phe 245 250 255 Ile Tyr Val Thr Pro Ser Gln Lys Glu Tyr Leu Glu Ile Asn Lys Ile 260 265 270 Pro Leu Val Leu Ser Ser Val Val Thr Pro Phe Leu Asn Pro Phe Ile 275 280 285 Tyr Thr Leu Arg Asn Asp Thr Val Gln Gly Val Leu Arg Asp Val Trp 290 295 300 Val Arg Val Arg Gly Val Phe Glu Lys Arg Met Arg Ala Val Leu Arg 305 310 315 320 Ser Arg Leu Ser Ser Asn Lys Asp His Gln Gly Arg Ala Cys Ser Ser 325 330 335 Pro Pro Cys Val Tyr Ser Val Lys Leu Gln Cys 340 345 <210> 615 <211> 939 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(939) <400> 615 atg gaa gca gaa aac ctt aca gaa tta tca aaa ttt ctc ctc ctg gga 48 Met Glu Ala Glu Asn Leu Thr Glu Leu Ser Lys Phe Leu Leu Leu Gly 1 5 10 15 ctc tca gat gat cct gaa ctg cag ccc gtc ctc ttt ggg ctg ttc ctg 96 Leu Ser Asp Asp Pro Glu Leu Gln Pro Val Leu Phe Gly Leu Phe Leu 20 25 30 tcc atg tac ctg gtc acg gtg ctg ggg aac ctg ctc atc att ctg gcc 144 Ser Met Tyr Leu Val Thr Val Leu Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 gtc agc tct gac tcc cac ctc cac acc ccc atg tac ttc ttc ctc tcc 192 Val Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 aac ctg tcc ttt gtt gac atc tgt ttc atc tcc acc aca gtc ccc aag 240 Asn Leu Ser Phe Val Asp Ile Cys Phe Ile Ser Thr Thr Val Pro Lys 65 70 75 80 atg cta gtg agc atc cag gca cgg agc aaa gac atc tcc tac atg ggg 288 Met Leu Val Ser Ile Gln Ala Arg Ser Lys Asp Ile Ser Tyr Met Gly 85 90 95 tgc ctc act cag gtg tat ttt tta atg atg ttt gct gga atg gat act 336 Cys Leu Thr Gln Val Tyr Phe Leu Met Met Phe Ala Gly Met Asp Thr 100 105 110 ttc cta ctg gcc gtg atg gcc tat gac cgg ttt gtg gcc atc tgc cac 384 Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125 cca ctg cac tac acg gtc atc atg aac ccc tgc ctc tgt ggc ctc ctg 432 Pro Leu His Tyr Thr Val Ile Met Asn Pro Cys Leu Cys Gly Leu Leu 130 135 140 gtt ctg gca tct tgg ttc atc att ttc tgg ttc tcc ctg gtt cat att 480 Val Leu Ala Ser Trp Phe Ile Ile Phe Trp Phe Ser Leu Val His Ile 145 150 155 160 cta ctg atg aag agg ttg acc ttc tcc aca ggc act gag att ccg cat 528 Leu Leu Met Lys Arg Leu Thr Phe Ser Thr Gly Thr Glu Ile Pro His 165 170 175 ttc ttc tgt gaa ccg gct cag gtc ctc aag gtg gcc tgc tct aac acc 576 Phe Phe Cys Glu Pro Ala Gln Val Leu Lys Val Ala Cys Ser Asn Thr 180 185 190 ctc ctc aat aac att gtc ttg tat gtg gcc acg gca ctg ctg ggt gtg 624 Leu Leu Asn Asn Ile Val Leu Tyr Val Ala Thr Ala Leu Leu Gly Val 195 200 205 ttt cct gta gct ggg atc ctc ttc tcc tac tct cag att gtc tcc tcc 672 Phe Pro Val Ala Gly Ile Leu Phe Ser Tyr Ser Gln Ile Val Ser Ser 210 215 220 tta atg gga atg tcc tcc acc aag ggc aag tac aaa gcc ttt tcc acc 720 Leu Met Gly Met Ser Ser Thr Lys Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 tgt gga tct cac ctc tgt gtg gtc tcc ttg ttc tat gga aca gga ctt 768 Cys Gly Ser His Leu Cys Val Val Ser Leu Phe Tyr Gly Thr Gly Leu 245 250 255 ggg gtc tat ctg agt tct gct gtg acc cat tct tcc cag agc agc tcc 816 Gly Val Tyr Leu Ser Ser Ala Val Thr His Ser Ser Gln Ser Ser Ser 260 265 270 acc gcc tca gtg atg tac gcc atg gtc acc ccc atg ctg aac ccc ttc 864 Thr Ala Ser Val Met Tyr Ala Met Val Thr Pro Met Leu Asn Pro Phe 275 280 285 atc tac agc ctg agg aac aag gat gtg aag ggg gcc ctg gaa aga ctc 912 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Gly Ala Leu Glu Arg Leu 290 295 300 ctc agc agg gcc gac tct tgt cca tga 939 Leu Ser Arg Ala Asp Ser Cys Pro 305 310 <210> 616 <211> 312 <212> PRT <213> Homo sapiens <400> 616 Met Glu Ala Glu Asn Leu Thr Glu Leu Ser Lys Phe Leu Leu Leu Gly 1 5 10 15 Leu Ser Asp Asp Pro Glu Leu Gln Pro Val Leu Phe Gly Leu Phe Leu 20 25 30 Ser Met Tyr Leu Val Thr Val Leu Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Val Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Val Asp Ile Cys Phe Ile Ser Thr Thr Val Pro Lys 65 70 75 80 Met Leu Val Ser Ile Gln Ala Arg Ser Lys Asp Ile Ser Tyr Met Gly 85 90 95 Cys Leu Thr Gln Val Tyr Phe Leu Met Met Phe Ala Gly Met Asp Thr 100 105 110 Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125 Pro Leu His Tyr Thr Val Ile Met Asn Pro Cys Leu Cys Gly Leu Leu 130 135 140 Val Leu Ala Ser Trp Phe Ile Ile Phe Trp Phe Ser Leu Val His Ile 145 150 155 160 Leu Leu Met Lys Arg Leu Thr Phe Ser Thr Gly Thr Glu Ile Pro His 165 170 175 Phe Phe Cys Glu Pro Ala Gln Val Leu Lys Val Ala Cys Ser Asn Thr 180 185 190 Leu Leu Asn Asn Ile Val Leu Tyr Val Ala Thr Ala Leu Leu Gly Val 195 200 205 Phe Pro Val Ala Gly Ile Leu Phe Ser Tyr Ser Gln Ile Val Ser Ser 210 215 220 Leu Met Gly Met Ser Ser Thr Lys Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Cys Val Val Ser Leu Phe Tyr Gly Thr Gly Leu 245 250 255 Gly Val Tyr Leu Ser Ser Ala Val Thr His Ser Ser Gln Ser Ser Ser 260 265 270 Thr Ala Ser Val Met Tyr Ala Met Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Gly Ala Leu Glu Arg Leu 290 295 300 Leu Ser Arg Ala Asp Ser Cys Pro 305 310 <210> 617 <211> 933 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(933) <400> 617 atg gga aag acc aaa aac aca tcg ctg gat gcc gtg gtg aca gat ttc 48 Met Gly Lys Thr Lys Asn Thr Ser Leu Asp Ala Val Val Thr Asp Phe 1 5 10 15 att ctt ctg ggt ttg tct cac ccc cca aat cta aga agc ctc ctc ttc 96 Ile Leu Leu Gly Leu Ser His Pro Pro Asn Leu Arg Ser Leu Leu Phe 20 25 30 ctg gtc ttc ttc atc att tac atc ctc act cag ctg ggg aac ctg ctc 144 Leu Val Phe Phe Ile Ile Tyr Ile Leu Thr Gln Leu Gly Asn Leu Leu 35 40 45 att ctg ctc acc atg tgg gct gac ccg aag ctc tgt gct cgc ccc atg 192 Ile Leu Leu Thr Met Trp Ala Asp Pro Lys Leu Cys Ala Arg Pro Met 50 55 60 tac att ctt ctg gga gtg ctc tca ttc ctg gac atg tgg ctc tcc tca 240 Tyr Ile Leu Leu Gly Val Leu Ser Phe Leu Asp Met Trp Leu Ser Ser 65 70 75 80 gtc acc gtt cct cgg ctt att ttg gat ttt act cct tcc atc aag gct 288 Val Thr Val Pro Arg Leu Ile Leu Asp Phe Thr Pro Ser Ile Lys Ala 85 90 95 atc ccg ttt ggt ggc tgt gtg gct caa ctg tat ttc ttt cac ttc ctg 336 Ile Pro Phe Gly Gly Cys Val Ala Gln Leu Tyr Phe Phe His Phe Leu 100 105 110 ggc agc acc cag tgc ttc ctc tac acc ttg atg gcc tat gac agg tac 384 Gly Ser Thr Gln Cys Phe Leu Tyr Thr Leu Met Ala Tyr Asp Arg Tyr 115 120 125 cta gca ata tgt cag ccc ctg cac tac cca gtg ctc atg aat ggg agg 432 Leu Ala Ile Cys Gln Pro Leu His Tyr Pro Val Leu Met Asn Gly Arg 130 135 140 tta tgc aca gtc ctt gtg gct gga gct tgg gtc gcc ggc tcc atg cat 480 Leu Cys Thr Val Leu Val Ala Gly Ala Trp Val Ala Gly Ser Met His 145 150 155 160 ggg tct atc cag gcc acc ttg acc ttc cgc ctg ccc tac tgt ggg ccc 528 Gly Ser Ile Gln Ala Thr Leu Thr Phe Arg Leu Pro Tyr Cys Gly Pro 165 170 175 aat cag gtg gat tac ttt atc tgt gac atc cgc gca gta ttg aga ctg 576 Asn Gln Val Asp Tyr Phe Ile Cys Asp Ile Arg Ala Val Leu Arg Leu 180 185 190 gcc tgt gct gac aca act gtc aat gag ctt gtg acc ttt gtg gac gtc 624 Ala Cys Ala Asp Thr Thr Val Asn Glu Leu Val Thr Phe Val Asp Val 195 200 205 agg gta gtg gcc gcc agt tgc ttc atg tta att ctg ctc tcc tat gcc 672 Arg Val Val Ala Ala Ser Cys Phe Met Leu Ile Leu Leu Ser Tyr Ala 210 215 220 aac ata gtc cat gcc atc ctg aag ata cgc acc gct gat ggg agg cgc 720 Asn Ile Val His Ala Ile Leu Lys Ile Arg Thr Ala Asp Gly Arg Arg 225 230 235 240 cgg gcc ttc tcc acc tgt ggc tcc cac cta atc gtg gtc aca gtc tac 768 Arg Ala Phe Ser Thr Cys Gly Ser His Leu Ile Val Val Thr Val Tyr 245 250 255 tat gtc ccc tgt att ttc atc tac ctt agg gct ggc tcc aaa gac ccc 816 Tyr Val Pro Cys Ile Phe Ile Tyr Leu Arg Ala Gly Ser Lys Asp Pro 260 265 270 ctg gat ggg gca gcg gct gtg ttt tac act gtt gtc act cca tta ctg 864 Leu Asp Gly Ala Ala Ala Val Phe Tyr Thr Val Val Thr Pro Leu Leu 275 280 285 aac ccc ctc atc tat aca ctg agg aac cag gaa gtg aag tct gcc ctg 912 Asn Pro Leu Ile Tyr Thr Leu Arg Asn Gln Glu Val Lys Ser Ala Leu 290 295 300 aag agg ata aca gca ggt tga 933 Lys Arg Ile Thr Ala Gly 305 310 <210> 618 <211> 310 <212> PRT <213> Homo sapiens <400> 618 Met Gly Lys Thr Lys Asn Thr Ser Leu Asp Ala Val Val Thr Asp Phe 1 5 10 15 Ile Leu Leu Gly Leu Ser His Pro Pro Asn Leu Arg Ser Leu Leu Phe 20 25 30 Leu Val Phe Phe Ile Ile Tyr Ile Leu Thr Gln Leu Gly Asn Leu Leu 35 40 45 Ile Leu Leu Thr Met Trp Ala Asp Pro Lys Leu Cys Ala Arg Pro Met 50 55 60 Tyr Ile Leu Leu Gly Val Leu Ser Phe Leu Asp Met Trp Leu Ser Ser 65 70 75 80 Val Thr Val Pro Arg Leu Ile Leu Asp Phe Thr Pro Ser Ile Lys Ala 85 90 95 Ile Pro Phe Gly Gly Cys Val Ala Gln Leu Tyr Phe Phe His Phe Leu 100 105 110 Gly Ser Thr Gln Cys Phe Leu Tyr Thr Leu Met Ala Tyr Asp Arg Tyr 115 120 125 Leu Ala Ile Cys Gln Pro Leu His Tyr Pro Val Leu Met Asn Gly Arg 130 135 140 Leu Cys Thr Val Leu Val Ala Gly Ala Trp Val Ala Gly Ser Met His 145 150 155 160 Gly Ser Ile Gln Ala Thr Leu Thr Phe Arg Leu Pro Tyr Cys Gly Pro 165 170 175 Asn Gln Val Asp Tyr Phe Ile Cys Asp Ile Arg Ala Val Leu Arg Leu 180 185 190 Ala Cys Ala Asp Thr Thr Val Asn Glu Leu Val Thr Phe Val Asp Val 195 200 205 Arg Val Val Ala Ala Ser Cys Phe Met Leu Ile Leu Leu Ser Tyr Ala 210 215 220 Asn Ile Val His Ala Ile Leu Lys Ile Arg Thr Ala Asp Gly Arg Arg 225 230 235 240 Arg Ala Phe Ser Thr Cys Gly Ser His Leu Ile Val Val Thr Val Tyr 245 250 255 Tyr Val Pro Cys Ile Phe Ile Tyr Leu Arg Ala Gly Ser Lys Asp Pro 260 265 270 Leu Asp Gly Ala Ala Ala Val Phe Tyr Thr Val Val Thr Pro Leu Leu 275 280 285 Asn Pro Leu Ile Tyr Thr Leu Arg Asn Gln Glu Val Lys Ser Ala Leu 290 295 300 Lys Arg Ile Thr Ala Gly 305 310 <210> 619 <211> 759 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(759) <400> 619 atg tac ttt ttt ctc agc aac ttg tct ttc atg gat atc tgc ttc aca 48 Met Tyr Phe Phe Leu Ser Asn Leu Ser Phe Met Asp Ile Cys Phe Thr 1 5 10 15 aca gtc ata gtg cct aag atg ctg gtg aat ttt cta tca gag aca aag 96 Thr Val Ile Val Pro Lys Met Leu Val Asn Phe Leu Ser Glu Thr Lys 20 25 30 gtt atc tcc tat gtg ggc tgc ctg gcc cag atg tac ttc ttt atg gca 144 Val Ile Ser Tyr Val Gly Cys Leu Ala Gln Met Tyr Phe Phe Met Ala 35 40 45 ttt ggg aac act gac agc tac ctg ctg gcc tct atg gcc atc gac cgg 192 Phe Gly Asn Thr Asp Ser Tyr Leu Leu Ala Ser Met Ala Ile Asp Arg 50 55 60 ctg gtg gcc atc tgc aac ccc tta cac tat gat gtg gtt atg aaa cca 240 Leu Val Ala Ile Cys Asn Pro Leu His Tyr Asp Val Val Met Lys Pro 65 70 75 80 cgg cat tgc ctg ctc atg cta ttg ggt tct tgc agc atc tcc cac cta 288 Arg His Cys Leu Leu Met Leu Leu Gly Ser Cys Ser Ile Ser His Leu 85 90 95 cat tcc ctg ttc cgc gtg cta ctt atg tct cgc ttg tct ttc tgt gcc 336 His Ser Leu Phe Arg Val Leu Leu Met Ser Arg Leu Ser Phe Cys Ala 100 105 110 tct cac atc att aag cac ttt ttc tgt gac acc cag cct gtg cta aag 384 Ser His Ile Ile Lys His Phe Phe Cys Asp Thr Gln Pro Val Leu Lys 115 120 125 ctc tcc tgc tct gac aca tcc tcc agc cag atg gtg gtg atg act gag 432 Leu Ser Cys Ser Asp Thr Ser Ser Ser Gln Met Val Val Met Thr Glu 130 135 140 acc tta gct gtc att gtg acc ccc ttc ctg tgt atc atc ttc tcc tac 480 Thr Leu Ala Val Ile Val Thr Pro Phe Leu Cys Ile Ile Phe Ser Tyr 145 150 155 160 ctg cga atc atg gtc act gtg ctc aga atc ccc tct gca gcc ggg aag 528 Leu Arg Ile Met Val Thr Val Leu Arg Ile Pro Ser Ala Ala Gly Lys 165 170 175 tgg aag gcc ttc tct acc tgt ggc tcc cac ctc act gca gta gcc ctt 576 Trp Lys Ala Phe Ser Thr Cys Gly Ser His Leu Thr Ala Val Ala Leu 180 185 190 ttc tat ggg agt att att tat gtc tat ttt agg ccc ctg tcc atg tac 624 Phe Tyr Gly Ser Ile Ile Tyr Val Tyr Phe Arg Pro Leu Ser Met Tyr 195 200 205 tca gtg gtt agg gac cgg gta gcc aca gtt atg tac aca gta gtg aca 672 Ser Val Val Arg Asp Arg Val Ala Thr Val Met Tyr Thr Val Val Thr 210 215 220 ccc atg ctg aac cct ttc atc tac agc ctg agg aac aaa gat atg aag 720 Pro Met Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys 225 230 235 240 agg ggt ttg aag aaa tta cag gac aga att tac cgg taa 759 Arg Gly Leu Lys Lys Leu Gln Asp Arg Ile Tyr Arg 245 250 <210> 620 <211> 252 <212> PRT <213> Homo sapiens <400> 620 Met Tyr Phe Phe Leu Ser Asn Leu Ser Phe Met Asp Ile Cys Phe Thr 1 5 10 15 Thr Val Ile Val Pro Lys Met Leu Val Asn Phe Leu Ser Glu Thr Lys 20 25 30 Val Ile Ser Tyr Val Gly Cys Leu Ala Gln Met Tyr Phe Phe Met Ala 35 40 45 Phe Gly Asn Thr Asp Ser Tyr Leu Leu Ala Ser Met Ala Ile Asp Arg 50 55 60 Leu Val Ala Ile Cys Asn Pro Leu His Tyr Asp Val Val Met Lys Pro 65 70 75 80 Arg His Cys Leu Leu Met Leu Leu Gly Ser Cys Ser Ile Ser His Leu 85 90 95 His Ser Leu Phe Arg Val Leu Leu Met Ser Arg Leu Ser Phe Cys Ala 100 105 110 Ser His Ile Ile Lys His Phe Phe Cys Asp Thr Gln Pro Val Leu Lys 115 120 125 Leu Ser Cys Ser Asp Thr Ser Ser Ser Gln Met Val Val Met Thr Glu 130 135 140 Thr Leu Ala Val Ile Val Thr Pro Phe Leu Cys Ile Ile Phe Ser Tyr 145 150 155 160 Leu Arg Ile Met Val Thr Val Leu Arg Ile Pro Ser Ala Ala Gly Lys 165 170 175 Trp Lys Ala Phe Ser Thr Cys Gly Ser His Leu Thr Ala Val Ala Leu 180 185 190 Phe Tyr Gly Ser Ile Ile Tyr Val Tyr Phe Arg Pro Leu Ser Met Tyr 195 200 205 Ser Val Val Arg Asp Arg Val Ala Thr Val Met Tyr Thr Val Val Thr 210 215 220 Pro Met Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys 225 230 235 240 Arg Gly Leu Lys Lys Leu Gln Asp Arg Ile Tyr Arg 245 250 <2 10> 621 <211> 759 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(759) <400> 621 atg tac ttt ttt ctc agc aac ttg tct ttc atg gat atc tgc ttc aca 48 Met Tyr Phe Phe Leu Ser Asn Leu Ser Phe Met Asp Ile Cys Phe Thr 1 5 10 15 aca gtc ata gtg cct aag atg ctg gtg aat ttt cta tca gag aca aag 96 Thr Val Ile Val Pro Lys Met Leu Val Asn Phe Leu Ser Glu Thr Lys 20 25 30 att atc tct tat gtg ggc tgc ctg atc cag atg tac ttc ttc atg gca 144 Ile Ile Ser Tyr Val Gly Cys Leu Ile Gln Met Tyr Phe Phe Met Ala 35 40 45 ttt ggg aac act gac agc tac ctg ctg gcc tct atg gcc atc gac cgg 192 Phe Gly Asn Thr Asp Ser Tyr Leu Leu Ala Ser Met Ala Ile Asp Arg 50 55 60 ctg gtg gcc atc tgc aac ccc tta cac tat gat gtg gtt atg aaa cca 240 Leu Val Ala Ile Cys Asn Pro Leu His Tyr Asp Val Val Met Lys Pro 65 70 75 80 tgg cat tgc cta ctc atg cta ttg ggt tct tgc agc atc tcc cac cta 288 Trp His Cys Leu Leu Met Leu Leu Gly Ser Cys Ser Ile Ser His Leu 85 90 95 cat tcc ctg ttc cgc gtg cta ctt atg tct cgc ttg tct ttc tgt gcc 336 His Ser Leu Phe Arg Val Leu Leu Met Ser Arg Leu Ser Phe Cys Ala 100 105 110 tct cac atc att aag cac ttt ttc tgt gac acc cag cct gtg cta aag 384 Ser His Ile Ile Lys His Phe Phe Cys Asp Thr Gln Pro Val Leu Lys 115 120 125 ctc tcc tgc tct gac aca tcc tcc agc cag atg gtg gtg atg act gag 432 Leu Ser Cys Ser Asp Thr Ser Ser Ser Gln Met Val Val Met Thr Glu 130 135 140 acc tta gct gtc att gtg acc ccc ttc ctg tgt acc atc ttc tcc tac 480 Thr Leu Ala Val Ile Val Thr Pro Phe Leu Cys Thr Ile Phe Ser Tyr 145 150 155 160 ctg caa atc atc gtc act gtg ctc aga atc ccc tct gca gcc ggg aag 528 Leu Gln Ile Ile Val Thr Val Leu Arg Ile Pro Ser Ala Ala Gly Lys 165 170 175 tgg aag gcc ttc tct acc tgt ggc tcc cac ctc act gta gtg gtc ctg 576 Trp Lys Ala Phe Ser Thr Cys Gly Ser His Leu Thr Val Val Val Leu 180 185 190 ttc tat ggg agt gtc atc tat gtc tat ttt agg cct ctg tcc atg tac 624 Phe Tyr Gly Ser Val Ile Tyr Val Tyr Phe Arg Pro Leu Ser Met Tyr 195 200 205 tca gtg atg aag ggc cgg gta gcc aca gtt atg tac aca gta gtg aca 672 Ser Val Met Lys Gly Arg Val Ala Thr Val Met Tyr Thr Val Val Thr 210 215 220 ccc atg ctg aac cct ttc atc tac agc ctg agg aac aaa gat atg aaa 720 Pro Met Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys 225 230 235 240 agg ggt ttg aag aaa tta aga cac aga att tac tca tag 759 Arg Gly Leu Lys Lys Leu Arg His Arg Ile Tyr Ser 245 250 <210> 622 <211> 252 <212> PRT <213> Homo sapiens <400> 622 Met Tyr Phe Phe Leu Ser Asn Leu Ser Phe Met Asp Ile Cys Phe Thr 1 5 10 15 Thr Val Ile Val Pro Lys Met Leu Val Asn Phe Leu Ser Glu Thr Lys 20 25 30 Ile Ile Ser Tyr Val Gly Cys Leu Ile Gln Met Tyr Phe Phe Met Ala 35 40 45 Phe Gly Asn Thr Asp Ser Tyr Leu Leu Ala Ser Met Ala Ile Asp Arg 50 55 60 Leu Val Ala Ile Cys Asn Pro Leu His Tyr Asp Val Val Met Lys Pro 65 70 75 80 Trp His Cys Leu Leu Met Leu Leu Gly Ser Cys Ser Ile Ser His Leu 85 90 95 His Ser Leu Phe Arg Val Leu Leu Met Ser Arg Leu Ser Phe Cys Ala 100 105 110 Ser His Ile Ile Lys His Phe Phe Cys Asp Thr Gln Pro Val Leu Lys 115 120 125 Leu Ser Cys Ser Asp Thr Ser Ser Ser Gln Met Val Val Met Thr Glu 130 135 140 Thr Leu Ala Val Ile Val Thr Pro Phe Leu Cys Thr Ile Phe Ser Tyr 145 150 155 160 Leu Gln Ile Ile Val Thr Val Leu Arg Ile Pro Ser Ala Ala Gly Lys 165 170 175 Trp Lys Ala Phe Ser Thr Cys Gly Ser His Leu Thr Val Val Val Leu 180 185 190 Phe Tyr Gly Ser Val Ile Tyr Val Tyr Phe Arg Pro Leu Ser Met Tyr 195 200 205 Ser Val Met Lys Gly Arg Val Ala Thr Val Met Tyr Thr Val Val Thr 210 215 220 Pro Met Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys 225 230 235 240 Arg Gly Leu Lys Lys Leu Arg His Arg Ile Tyr Ser 245 250 <210> 623 <211> 933 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(933) <400> 623 atg ggg gaa aat cag aca atg gtc aca gag ttc ctc cta ctg gga ttt 48 Met Gly Glu Asn Gln Thr Met Val Thr Glu Phe Leu Leu Leu Gly Phe 1 5 10 15 ctc ctg ggc cca agg att cag atg ctc ctc ttt ggg ctc ttc tcc ctg 96 Leu Leu Gly Pro Arg Ile Gln Met Leu Leu Phe Gly Leu Phe Ser Leu 20 25 30 ttc tat atc ttc acc ctg ctg ggg aac ggg gcc atc ctg ggg ctc atc 144 Phe Tyr Ile Phe Thr Leu Leu Gly Asn Gly Ala Ile Leu Gly Leu Ile 35 40 45 tca ctg gac tcc aga ctc cac acc ccc atg tac ttc ttc ctc tca cac 192 Ser Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser His 50 55 60 ctg gct gtc gtc gac atc gcc tac acc cgc aac acg gtg ccc cag atg 240 Leu Ala Val Val Asp Ile Ala Tyr Thr Arg Asn Thr Val Pro Gln Met 65 70 75 80 ctg gcg aac ctc ctg cat cca gcc aag ccc atc tcc ttt gct ggt tgc 288 Leu Ala Asn Leu Leu His Pro Ala Lys Pro Ile Ser Phe Ala Gly Cys 85 90 95 atg acg cag acc ttt ctc tgt ttg agt ttt gga cac agc gaa tgt ctc 336 Met Thr Gln Thr Phe Leu Cys Leu Ser Phe Gly His Ser Glu Cys Leu 100 105 110 ctg ctg gtg ctg atg tcc tac gat cgt tac gtg gcc atc tgc cac cct 384 Leu Leu Val Leu Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys His Pro 115 120 125 ctc cga tac tcc gtc atc atg acc tgg aga gtc tgc atc acc ctg gcc 432 Leu Arg Tyr Ser Val Ile Met Thr Trp Arg Val Cys Ile Thr Leu Ala 130 135 140 gtc act tcc tgg acg tgt ggc tcc ctc ctg gct ctg gcc cat gtg gtt 480 Val Thr Ser Trp Thr Cys Gly Ser Leu Leu Ala Leu Ala His Val Val 145 150 155 160 ctc atc cta aga ctg ccc ttc tct ggg cct cat gaa atc aac cac ttc 528 Leu Ile Leu Arg Leu Pro Phe Ser Gly Pro His Glu Ile Asn His Phe 165 170 175 ttc tgt gaa atc ctg tct gtc ctc agg ctg gcc tgt gct gac acc tgg 576 Phe Cys Glu Ile Leu Ser Val Leu Arg Leu Ala Cys Ala Asp Thr Trp 180 185 190 ctc aac cag gtg gtc atc ttt gca gcc tgc gtg ttc ttc ctg gtg ggg 624 Leu Asn Gln Val Val Ile Phe Ala Ala Cys Val Phe Phe Leu Val Gly 195 200 205 cca ccc agc ctg gtg ctt gtc tcc tac tcg cac atc ctg gcg gcc atc 672 Pro Pro Ser Leu Val Leu Val Ser Tyr Ser His Ile Leu Ala Ala Ile 210 215 220 ctg agg atc cag tct ggg gag ggc cgc aga aag gcc ttc tcc acc tgc 720 Leu Arg Ile Gln Ser Gly Glu Gly Arg Arg Lys Ala Phe Ser Thr Cys 225 230 235 240 tcc tcc cac ctc tgc gtg gtg gga ctc ttc ttt ggc agt gcc atc atc 768 Ser Ser His Leu Cys Val Val Gly Leu Phe Phe Gly Ser Ala Ile Ile 245 250 255 atg tac atg gcc ccc aag tcc cgc cat cct gag gag cag caa aag gtc 816 Met Tyr Met Ala Pro Lys Ser Arg His Pro Glu Glu Gln Gln Lys Val 260 265 270 ttt ttt cta ttt tac agt ttt ttc aac cca aca ctt aac ccc ctg att 864 Phe Phe Leu Phe Tyr Ser Phe Phe Asn Pro Thr Leu Asn Pro Leu Ile 275 280 285 tac agc ctg agg aac gga gag gtc aag ggt gcc ctg agg aga gca ctg 912 Tyr Ser Leu Arg Asn Gly Glu Val Lys Gly Ala Leu Arg Arg Ala Leu 290 295 300 ggc aag gaa agt cat tcc taa 933 Gly Lys Glu Ser His Ser 305 310 <210> 624 <211> 310 <212> PRT <213> Homo sapiens <400> 624 Met Gly Glu Asn Gln Thr Met Val Thr Glu Phe Leu Leu Leu Gly Phe 1 5 10 15 Leu Leu Gly Pro Arg Ile Gln Met Leu Leu Phe Gly Leu Phe Ser Leu 20 25 30 Phe Tyr Ile Phe Thr Leu Leu Gly Asn Gly Ala Ile Leu Gly Leu Ile 35 40 45 Ser Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser His 50 55 60 Leu Ala Val Val Asp Ile Ala Tyr Thr Arg Asn Thr Val Pro Gln Met 65 70 75 80 Leu Ala Asn Leu Leu His Pro Ala Lys Pro Ile Ser Phe Ala Gly Cys 85 90 95 Met Thr Gln Thr Phe Leu Cys Leu Ser Phe Gly His Ser Glu Cys Leu 100 105 110 Leu Leu Val Leu Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys His Pro 115 120 125 Leu Arg Tyr Ser Val Ile Met Thr Trp Arg Val Cys Ile Thr Leu Ala 130 135 140 Val Thr Ser Trp Thr Cys Gly Ser Leu Leu Ala Leu Ala His Val Val 145 150 155 160 Leu Ile Leu Arg Leu Pro Phe Ser Gly Pro His Glu Ile Asn His Phe 165 170 175 Phe Cys Glu Ile Leu Ser Val Leu Arg Leu Ala Cys Ala Asp Thr Trp 180 185 190 Leu Asn Gln Val Val Ile Phe Ala Ala Cys Val Phe Phe Leu Val Gly 195 200 205 Pro Pro Ser Leu Val Leu Val Ser Tyr Ser His Ile Leu Ala Ala Ile 210 215 220 Leu Arg Ile Gln Ser Gly Glu Gly Arg Arg Lys Ala Phe Ser Thr Cys 225 230 235 240 Ser Ser His Leu Cys Val Val Gly Leu Phe Phe Gly Ser Ala Ile Ile 245 250 255 Met Tyr Met Ala Pro Lys Ser Arg His Pro Glu Glu Gln Gln Lys Val 260 265 270 Phe Phe Leu Phe Tyr Ser Phe Phe Asn Pro Thr Leu Asn Pro Leu Ile 275 280 285 Tyr Ser Leu Arg Asn Gly Glu Val Lys Gly Ala Leu Arg Arg Ala Leu 290 295 300 Gly Lys Glu Ser His Ser 305 310 <210> 625 <211> 1008 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1008) <400> 625 atg att gaa ttt tca ttt ttt ttg ttt gtt tgt ttg ttt caa tgg ttt 48 Met Ile Glu Phe Ser Phe Phe Leu Phe Val Cys Leu Phe Gln Trp Phe 1 5 10 15 ctc tgt agg aac gtg ggg gaa gat cct atg gaa cca cag aac acc aca 96 Leu Cys Arg Asn Val Gly Glu Asp Pro Met Glu Pro Gln Asn Thr Thr 20 25 30 cag gta tca atg ttt gtc ctc tta ggg ttt tca cag acc caa gag ctc 144 Gln Val Ser Met Phe Val Leu Leu Gly Phe Ser Gln Thr Gln Glu Leu 35 40 45 cag aaa ttc ctg ttc ctt ctg ttc ctg tta gtc tat gtt acc acc att 192 Gln Lys Phe Leu Phe Leu Leu Phe Leu Leu Val Tyr Val Thr Thr Ile 50 55 60 gtg gga aac ctc ctt atc atg gtc aca gtg act ttt gac tgc cgg ctc 240 Val Gly Asn Leu Leu Ile Met Val Thr Val Thr Phe Asp Cys Arg Leu 65 70 75 80 cac aca ccc atg tat ttt ctg ctc cga aat cta gct ctc ata gac ctc 288 His Thr Pro Met Tyr Phe Leu Leu Arg Asn Leu Ala Leu Ile Asp Leu 85 90 95 tgc tat tcc aca gtc acc tct cca aag atg ctg gtg gac ttc ctc cat 336 Cys Tyr Ser Thr Val Thr Ser Pro Lys Met Leu Val Asp Phe Leu His 100 105 110 gag acc aag acg atc tcc tac cag ggc tgc atg gcc cag atc ttc ttc 384 Glu Thr Lys Thr Ile Ser Tyr Gln Gly Cys Met Ala Gln Ile Phe Phe 115 120 125 ttc cac ctt ttg gga ggt ggg act gtc ttt ttt ctc tca gtc atg gcc 432 Phe His Leu Leu Gly Gly Gly Thr Val Phe Phe Leu Ser Val Met Ala 130 135 140 tat gac cgc tac ata gcc atc tcc cag ccc ctc cgg tat gtc acc atc 480 Tyr Asp Arg Tyr Ile Ala Ile Ser Gln Pro Leu Arg Tyr Val Thr Ile 145 150 155 160 atg aac act caa ttg tgt gtg ggc ctg gta gta gcc gcc tgg gtg ggg 528 Met Asn Thr Gln Leu Cys Val Gly Leu Val Val Ala Ala Trp Val Gly 165 170 175 ggc ttt gtc cac tcc att gtc caa ctg gct ctg ata ctt cca ctg ccc 576 Gly Phe Val His Ser Ile Val Gln Leu Ala Leu Ile Leu Pro Leu Pro 180 185 190 ttc tgt ggc ccc aat atc cta gat aac ttc tac tgt gat gtt ccc caa 624 Phe Cys Gly Pro Asn Ile Leu Asp Asn Phe Tyr Cys Asp Val Pro Gln 195 200 205 gta ctg aga ctt gcc tgc act gat acc tcc ctc ctg gag ttc ctc atg 672 Val Leu Arg Leu Ala Cys Thr Asp Thr Ser Leu Leu Glu Phe Leu Met 210 215 220 atc tcc aac agt ggg ctg cta gtt atc atc tgg ttc ctc ctc ctt ctg 720 Ile Ser Asn Ser Gly Leu Leu Val Ile Ile Trp Phe Leu Leu Leu Leu 225 230 235 240 atc tct tat act gtc atc ctg gtg atg ctg agg tcc cac tcg gga aag 768 Ile Ser Tyr Thr Val Ile Leu Val Met Leu Arg Ser His Ser Gly Lys 245 250 255 gca agg agg aag gca gct tcc acc tgc acc acc cac atc atc gtg gtg 816 Ala Arg Arg Lys Ala Ala Ser Thr Cys Thr Thr His Ile Ile Val Val 260 265 270 tcc atg atc ttc att ccc tgt atc tat atc tat acc tgg ccc ttc acc 864 Ser Met Ile Phe Ile Pro Cys Ile Tyr Ile Tyr Thr Trp Pro Phe Thr 275 280 285 cca ttc ctc atg gac aag gct gtg tcc atc agc tac aca gtc atg acc 912 Pro Phe Leu Met Asp Lys Ala Val Ser Ile Ser Tyr Thr Val Met Thr 290 295 300 ccc atg ctc aac ccc atg atc tac acc ctg aga aac cag gac atg aaa 960 Pro Met Leu Asn Pro Met Ile Tyr Thr Leu Arg Asn Gln Asp Met Lys 305 310 315 320 gca gcc atg agg aga tta ggc aag tgc cta gta att tgc agg gag taa 1008 Ala Ala Met Arg Arg Leu Gly Lys Cys Leu Val Ile Cys Arg Glu 325 330 335 <210> 626 <211> 335 <212> PRT <2 13> Homo sapiens <400> 626 Met Ile Glu Phe Ser Phe Phe Leu Phe Val Cys Leu Phe Gln Trp Phe 1 5 10 15 Leu Cys Arg Asn Val Gly Glu Asp Pro Met Glu Pro Gln Asn Thr Thr 20 25 30 Gln Val Ser Met Phe Val Leu Leu Gly Phe Ser Gln Thr Gln Glu Leu 35 40 45 Gln Lys Phe Leu Phe Leu Leu Phe Leu Leu Val Tyr Val Thr Thr Ile 50 55 60 Val Gly Asn Leu Leu Ile Met Val Thr Val Thr Phe Asp Cys Arg Leu 65 70 75 80 His Thr Pro Met Tyr Phe Leu Leu Arg Asn Leu Ala Leu Ile Asp Leu 85 90 95 Cys Tyr Ser Thr Val Thr Ser Pro Lys Met Leu Val Asp Phe Leu His 100 105 110 Glu Thr Lys Thr Ile Ser Tyr Gln Gly Cys Met Ala Gln Ile Phe Phe 115 120 125 Phe His Leu Leu Gly Gly Gly Thr Val Phe Phe Leu Ser Val Met Ala 130 135 140 Tyr Asp Arg Tyr Ile Ala Ile Ser Gln Pro Leu Arg Tyr Val Thr Ile 145 150 155 160 Met Asn Thr Gln Leu Cys Val Gly Leu Val Val Ala Ala Trp Val Gly 165 170 175 Gly Phe Val His Ser Ile Val Gln Leu Ala Leu Ile Leu Pro Leu Pro 180 185 190 Phe Cys Gly Pro Asn Ile Leu Asp Asn Phe Tyr Cys Asp Val Pro Gln 195 200 205 Val Leu Arg Leu Ala Cys Thr Asp Thr Ser Leu Leu Glu Phe Leu Met 210 215 220 Ile Ser Asn Ser Gly Leu Leu Val Ile Ile Trp Phe Leu Leu Leu Leu 225 230 235 240 Ile Ser Tyr Thr Val Ile Leu Val Met Leu Arg Ser His Ser Gly Lys 245 250 255 Ala Arg Arg Lys Ala Ala Ser Thr Cys Thr Thr His Ile Ile Val Val 260 265 270 Ser Met Ile Phe Ile Pro Cys Ile Tyr Ile Tyr Thr Trp Pro Phe Thr 275 280 285 Pro Phe Leu Met Asp Lys Ala Val Ser Ile Ser Tyr Thr Val Met Thr 290 295 300 Pro Met Leu Asn Pro Met Ile Tyr Thr Leu Arg Asn Gln Asp Met Lys 305 310 315 320 Ala Ala Met Arg Arg Leu Gly Lys Cys Leu Val Ile Cys Arg Glu 325 330 335 <210> 627 <21 1> 924 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(924) <400> 627 atg gaa aca ggg aac ctc acg tgg gta tca gac ttt gtc ttc ctg ggg 48 Met Glu Thr Gly Asn Leu Thr Trp Val Ser Asp Phe Val Phe Leu Gly 1 5 10 15 ctc tcg cag act cgg gag ctc cag cgt ttc ctg ttt cta atg ttc ctg 96 Leu Ser Gln Thr Arg Glu Leu Gln Arg Phe Leu Phe Leu Met Phe Leu 20 25 30 ttt gtc tac atc acc act gtt atg gga aac atc ctt atc atc atc aca 144 Phe Val Tyr Ile Thr Thr Val Met Gly Asn Ile Leu Ile Ile Ile Thr 35 40 45 gtg acc tct gat tcc cag ctc cac aca ccc atg tac ttt ctg ctc cga 192 Val Thr Ser Asp Ser Gln Leu His Thr Pro Met Tyr Phe Leu Leu Arg 50 55 60 aac ctg gct gtc cta gac ctc tgt ttc tct tca gtc act gct ccc aaa 240 Asn Leu Ala Val Leu Asp Leu Cys Phe Ser Ser Val Thr Ala Pro Lys 65 70 75 80 atg cta gtg gac ctc ctc tct gag aag aaa acc atc tct tac cag ggc 288 Met Leu Val Asp Leu Leu Ser Glu Lys Lys Thr Ile Ser Tyr Gln Gly 85 90 95 tgc atg ggt cag atc ttc ttc ttc cac ttt ttg gga ggt gcc atg gtc 336 Cys Met Gly Gln Ile Phe Phe Phe His Phe Leu Gly Gly Ala Met Val 100 105 110 ttc ttc ctc tca gtg atg gcc ttt gac cgc ctc att gcc atc tcc cgg 384 Phe Phe Leu Ser Val Met Ala Phe Asp Arg Leu Ile Ala Ile Ser Arg 115 120 125 ccc ctc cgc tat gtc acc gtc atg aac act cag ctc tgg gtg ggg ctg 432 Pro Leu Arg Tyr Val Thr Val Met Asn Thr Gln Leu Trp Val Gly Leu 130 135 140 gtg gta gcc acc tgg gtg gga ggc ttt gtc cac tct att gtc cag ctg 480 Val Val Ala Thr Trp Val Gly Gly Phe Val His Ser Ile Val Gln Leu 145 150 155 160 gct ctg atg ctc cca ctg ccc ttc tgt ggc ccc aac att ttg gat aac 528 Ala Leu Met Leu Pro Leu Pro Phe Cys Gly Pro Asn Ile Leu Asp Asn 165 170 175 ttc tac tgt gat gtt ccc caa gta ctg aga ctt gcc tgc act gac acc 576 Phe Tyr Cys Asp Val Pro Gln Val Leu Arg Leu Ala Cys Thr Asp Thr 180 185 190 tca ctg ctg gag ttc ctc aag atc tcc aac agt ggg ctg ctg gat gtc 624 Ser Leu Leu Glu Phe Leu Lys Ile Ser Asn Ser Gly Leu Leu Asp Val 195 200 205 gtc tgg ttc ttc ctc ctc ctg atg tcc tac tta ttc atc ctg gtg atg 672 Val Trp Phe Phe Leu Leu Leu Met Ser Tyr Leu Phe Ile Leu Val Met 210 215 220 ctg agg tca cat cca ggg gag gca aga agg aag gca gct tcc acc tgc 720 Leu Arg Ser His Pro Gly Glu Ala Arg Arg Lys Ala Ala Ser Thr Cys 225 230 235 240 acc acc cac atc atc gtg gtt tcc atg atc ttc gtt cca agc att tac 768 Thr Thr His Ile Ile Val Val Ser Met Ile Phe Val Pro Ser Ile Tyr 245 250 255 ctc tat gcc cgg ccc ttc act cca ttc cct atg gac aag ctt gtg tcc 816 Leu Tyr Ala Arg Pro Phe Thr Pro Phe Pro Met Asp Lys Leu Val Ser 260 265 270 atc ggc cac aca gtc atg acc ccc atg ctc aac ccc atg atc tat acc 864 Ile Gly His Thr Val Met Thr Pro Met Leu Asn Pro Met Ile Tyr Thr 275 280 285 ctg agg aac cag gac atg cag gca gca gtg aga aga tta ggg aga cac 912 Leu Arg Asn Gln Asp Met Gln Ala Ala Val Arg Arg Leu Gly Arg His 290 295 300 cgg ctg gtt tga 924 Arg Leu Val 305 <210> 628 <211> 307 <212> PRT <213> Homo sapiens <400> 628 M et Glu Thr Gly Asn Leu Thr Trp Val Ser Asp Phe Val Phe Leu Gly 1 5 10 15 Leu Ser Gln Thr Arg Glu Leu Gln Arg Phe Leu Phe Leu Met Phe Leu 20 25 30 Phe Val Tyr Ile Thr Thr Val Met Gly Asn Ile Leu Ile Ile Ile Thr 35 40 45 Val Thr Ser Asp Ser Gln Leu His Thr Pro Met Tyr Phe Leu Leu Arg 50 55 60 Asn Leu Ala Val Leu Asp Leu Cys Phe Ser Ser Val Thr Ala Pro Lys 65 70 75 80 Met Leu Val Asp Leu Leu Ser Glu Lys Lys Thr Ile Ser Tyr Gln Gly 85 90 95 Cys Met Gly Gln Ile Phe Phe Phe His Phe Leu Gly Gly Ala Met Val 100 105 110 Phe Phe Leu Ser Val Met Ala Phe Asp Arg Leu Ile Ala Ile Ser Arg 115 120 125 Pro Leu Arg Tyr Val Thr Val Met Asn Thr Gln Leu Trp Val Gly Leu 130 135 140 Val Val Ala Thr Trp Val Gly Gly Phe Val His Ser Ile Val Gln Leu 145 150 155 160 Ala Leu Met Leu Pro Leu Pro Phe Cys Gly Pro Asn Ile Leu Asp Asn 165 170 175 Phe Tyr Cys Asp Val Pro Gln Val Leu Arg Leu Ala Cys Thr Asp Thr 180 185 190 Ser Leu Leu Glu Phe Leu Lys Ile Ser Asn Ser Gly Leu Leu Asp Val 195 200 205 Val Trp Phe Phe Leu Leu Leu Met Ser Tyr Leu Phe Ile Leu Val Met 210 215 220 Leu Arg Ser His Pro Gly Glu Ala Arg Arg Lys Ala Ala Ser Thr Cys 225 230 235 240 Thr Thr His Ile Ile Val Val Ser Met Ile Phe Val Pro Ser Ile Tyr 245 250 255 Leu Tyr Ala Arg Pro Phe Thr Pro Phe Pro Met Asp Lys Leu Val Ser 260 265 270 Ile Gly His Thr Val Met Thr Pro Met Leu Asn Pro Met Ile Tyr Thr 275 280 285 Leu Arg Asn Gln Asp Met Gln Ala Ala Val Arg Arg Leu Gly Arg His 290 295 300 Arg Leu Val 305 <210> 629 <211> 999 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(999) <400> 629 atg agt gat ctt ttc ttt ctc tct aca ggt cat cca aga gcg agc tgt 48 Met Ser Asp Leu Phe Phe Leu Ser Thr Gly His Pro Arg Ala Ser Cys 1 5 10 15 agg atg gag gcc atg aaa cta tta aat caa tct caa gtg tca gaa ttc 96 Arg Met Glu Ala Met Lys Leu Leu Asn Gln Ser Gln Val Ser Glu Phe 20 25 30 att ttg ctg gga ctg acc agc tcc cag gat gta gag ttt ctt ctc ttt 144 Ile Leu Leu Gly Leu Thr Ser Ser Gln Asp Val Glu Phe Leu Leu Phe 35 40 45 gcc ctc ttc tcg gtt atc tat gtg gtc aca gtt ttg ggt aac ctt ctt 192 Ala Leu Phe Ser Val Ile Tyr Val Val Thr Val Leu Gly Asn Leu Leu 50 55 60 att ata gtc aca gtg ttt aac acc cct aac ctg aat act ccc atg tat 240 Ile Ile Val Thr Val Phe Asn Thr Pro Asn Leu Asn Thr Pro Met Tyr 65 70 75 80 ttt ctc ctt ggt aat ctc tct ttt gta gat atg acc ctt gct tct ttt 288 Phe Leu Leu Gly Asn Leu Ser Phe Val Asp Met Thr Leu Ala Ser Phe 85 90 95 gcc acc cct aag gtg att ctg aac ttg tta aaa aag cag aag gta att 336 Ala Thr Pro Lys Val Ile Leu Asn Leu Leu Lys Lys Gln Lys Val Ile 100 105 110 tct ttt gct ggg tgc ttc act cag ata ttt ctc ctt cac tta ctg ggt 384 Ser Phe Ala Gly Cys Phe Thr Gln Ile Phe Leu Leu His Leu Leu Gly 115 120 125 ggg gtt gaa atg gta ctg ttg gtc tcc atg gct ttt gac aga tat gtg 432 Gly Val Glu Met Val Leu Leu Val Ser Met Ala Phe Asp Arg Tyr Val 130 135 140 gcc att tgt aag ccc cta cac tac atg acc atc atg aac aag aag gta 480 Ala Ile Cys Lys Pro Leu His Tyr Met Thr Ile Met Asn Lys Lys Val 145 150 155 160 tgt gtt ttg ctt gta gtg acc tca tgg ctc ttg ggt ctc ctt cac tca 528 Cys Val Leu Leu Val Val Thr Ser Trp Leu Leu Gly Leu Leu His Ser 165 170 175 ggg ttt cag ata cca ttt gct gtg aac ttg ccc ttt tgt ggt ccc aat 576 Gly Phe Gln Ile Pro Phe Ala Val Asn Leu Pro Phe Cys Gly Pro Asn 180 185 190 gtg gta gac agc att ttt tgt gac ctc cct ttg gtt act aag ctt gcc 624 Val Val Asp Ser Ile Phe Cys Asp Leu Pro Leu Val Thr Lys Leu Ala 195 200 205 tgt ata gac ata tat ttt gta cag gta gtc att gtt gcc aac agt ggc 672 Cys Ile Asp Ile Tyr Phe Val Gln Val Val Ile Val Ala Asn Ser Gly 210 215 220 ata atc tcc ctg agc tgt ttc att att ttg ctt atc tcc tac agt ctg 720 Ile Ile Ser Leu Ser Cys Phe Ile Ile Leu Leu Ile Ser Tyr Ser Leu 225 230 235 240 atc ctc ata acc att aag aac cac tct cct act ggg caa tct aaa gcc 768 Ile Leu Ile Thr Ile Lys Asn His Ser Pro Thr Gly Gln Ser Lys Ala 245 250 255 cgt tcc act ttg act gct cac atc aca gtg gtg att ctc ttc ttt ggc 816 Arg Ser Thr Leu Thr Ala His Ile Thr Val Val Ile Leu Phe Phe Gly 260 265 270 cca tgc atc ttt atc tac att tgg ccc ttc ggc aac cac tct gta gat 864 Pro Cys Ile Phe Ile Tyr Ile Trp Pro Phe Gly Asn His Ser Val Asp 275 280 285 aag ttc ctt gct gtg ttt tat acc atc atc act cct atc ttg aat cca 912 Lys Phe Leu Ala Val Phe Tyr Thr Ile Ile Thr Pro Ile Leu Asn Pro 290 295 300 att atc tat act ctg aga aac aaa gaa atg aag ata tcc atg aaa aaa 960 Ile Ile Tyr Thr Leu Arg Asn Lys Glu Met Lys Ile Ser Met Lys Lys 305 310 315 320 ctc tgg aga gct ttt gtg aat tct aga gaa gat act tag 999 Leu Trp Arg Ala Phe Val Asn Ser Arg Glu Asp Thr 325 330 <210> 630 <211> 332 <212> PRT <213> Homo sapiens <400> 630 Met Ser Asp Leu Phe Phe Leu Ser Thr Gly His Pro Arg Ala Ser Cys 1 5 10 15 Arg Met Glu Ala Met Lys Leu Leu Asn Gln Ser Gln Val Ser Glu Phe 20 25 30 Ile Leu Leu Gly Leu Thr Ser Ser Gln Asp Val Glu Phe Leu Leu Phe 35 40 45 Ala Leu Phe Ser Val Ile Tyr Val Val Thr Val Leu Gly Asn Leu Leu 50 55 60 Ile Ile Val Thr Val Phe Asn Thr Pro Asn Leu Asn Thr Pro Met Tyr 65 70 75 80 Phe Leu Leu Gly Asn Leu Ser Phe Val Asp Met Thr Leu Ala Ser Phe 85 90 95 Ala Thr Pro Lys Val Ile Leu Asn Leu Leu Lys Lys Gln Lys Val Ile 100 105 110 Ser Phe Ala Gly Cys Phe Thr Gln Ile Phe Leu Leu His Leu Leu Gly 115 120 125 Gly Val Glu Met Val Leu Leu Val Ser Met Ala Phe Asp Arg Tyr Val 130 135 140 Ala Ile Cys Lys Pro Leu His Tyr Met Thr Ile Met Asn Lys Lys Val 145 150 155 160 Cys Val Leu Leu Val Val Thr Ser Trp Leu Leu Gly Leu Leu His Ser 165 170 175 Gly Phe Gln Ile Pro Phe Ala Val Asn Leu Pro Phe Cys Gly Pro Asn 180 185 190 Val Val Asp Ser Ile Phe Cys Asp Leu Pro Leu Val Thr Lys Leu Ala 195 200 205 Cys Ile Asp Ile Tyr Phe Val Gln Val Val Ile Val Ala Asn Ser Gly 210 215 220 Ile Ile Ser Leu Ser Cys Phe Ile Ile Leu Leu Ile Ser Tyr Ser Leu 225 230 235 240 Ile Leu Ile Thr Ile Lys Asn His Ser Pro Thr Gly Gln Ser Lys Ala 245 250 255 Arg Ser Thr Leu Thr Ala His Ile Thr Val Val Ile Leu Phe Phe Gly 260 265 270 Pro Cys Ile Phe Ile Tyr Ile Trp Pro Phe Gly Asn His Ser Val Asp 275 280 285 Lys Phe Leu Ala Val Phe Tyr Thr Ile Ile Thr Pro Ile Leu Asn Pro 290 295 300 Ile Ile Tyr Thr Leu Arg Asn Lys Glu Met Lys Ile Ser Met Lys Lys 305 310 315 320 Leu Trp Arg Ala Phe Val Asn Ser Arg Glu Asp Thr 325 330 <210> 631 <211> 915 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(915) <400> 631 atg gaa aga gca aac cat tca gtg gta tcg gaa ttt att ttg ttg gga 48 Met Glu Arg Ala Asn His Ser Val Val Ser Glu Phe Ile Leu Leu Gly 1 5 10 15 ctt tcc aaa tct caa aat ctt cag att tta ttc ttc ttg gga ttc tct 96 Leu Ser Lys Ser Gln Asn Leu Gln Ile Leu Phe Phe Leu Gly Phe Ser 20 25 30 gtg gtc ttc gtg ggg att gtg tta gga aac ctg ctc atc ttg gtg act 144 Val Val Phe Val Gly Ile Val Leu Gly Asn Leu Leu Ile Leu Val Thr 35 40 45 gtg acc ttt gat tcg ctc ctt cac aca cca atg tat ttt ctg ctt agc 192 Val Thr Phe Asp Ser Leu Leu His Thr Pro Met Tyr Phe Leu Leu Ser 50 55 60 aac ctc tcc tgc att gat atg atc ctg gct tct ttt gct acc cct aag 240 Asn Leu Ser Cys Ile Asp Met Ile Leu Ala Ser Phe Ala Thr Pro Lys 65 70 75 80 atg att gta gat ttc ctc cga gaa cgt aag acc atc tca tgg tgg gga 288 Met Ile Val Asp Phe Leu Arg Glu Arg Lys Thr Ile Ser Trp Trp Gly 85 90 95 tgt tat tcc cag atg ttc ttt atg cac ctc ctg ggt ggg agt gag atg 336 Cys Tyr Ser Gln Met Phe Phe Met His Leu Leu Gly Gly Ser Glu Met 100 105 110 atg ttg ctt gta gcc atg gca ata gac agg tat gtt gcc ata tgc aaa 384 Met Leu Leu Val Ala Met Ala Ile Asp Arg Tyr Val Ala Ile Cys Lys 115 120 125 ccc ctc cat tac atg acc atc atg agc cca cgg gtg ctc act ggg cta 432 Pro Leu His Tyr Met Thr Ile Met Ser Pro Arg Val Leu Thr Gly Leu 130 135 140 ctg tta tcc tcc tat gca gtt gga ttt gtg cac tca tct agt caa atg 480 Leu Leu Ser Ser Tyr Ala Val Gly Phe Val His Ser Ser Ser Gln Met 145 150 155 160 gct ttc atg ttg act ttg ccc ttc tgt ggt ccc aat gtt ata gac agc 528 Ala Phe Met Leu Thr Leu Pro Phe Cys Gly Pro Asn Val Ile Asp Ser 165 170 175 ttt ttc tgt gac ctt ccc ctt gtg att aaa ctt gcc tgc aag gac acc 576 Phe Phe Cys Asp Leu Pro Leu Val Ile Lys Leu Ala Cys Lys Asp Thr 180 185 190 tac atc cta cag ctc ctg gtc att gct gac agt ggg ctc ctg tca ctg 624 Tyr Ile Leu Gln Leu Leu Val Ile Ala Asp Ser Gly Leu Leu Ser Leu 195 200 205 gtc tgc ttc ctc ctc ttg ctt gtc tcc tat gga gtc ata ata ttc tca 672 Val Cys Phe Leu Leu Leu Leu Val Ser Tyr Gly Val Ile Ile Phe Ser 210 215 220 gtt agg tac cgt gct gct agt cga tcc tct aag gct ttc tcc act ctc 720 Val Arg Tyr Arg Ala Ala Ser Arg Ser Ser Lys Ala Phe Ser Thr Leu 225 230 235 240 tca gct cac atc aca gtt gtg act ctg ttc ttt gct ccg tgt gtc ttt 768 Ser Ala His Ile Thr Val Val Thr Leu Phe Phe Ala Pro Cys Val Phe 245 250 255 atc tac gtc tgg ccc ttc agc aga tac tcg gta gat aaa att ctt tct 816 Ile Tyr Val Trp Pro Phe Ser Arg Tyr Ser Val Asp Lys Ile Leu Ser 260 265 270 gtg ttt tac aca att ttc aca cct ctc tta aat cct att att tat aca 864 Val Phe Tyr Thr Ile Phe Thr Pro Leu Leu Asn Pro Ile Ile Tyr Thr 275 280 285 tta aga aat caa gag gta aaa gca gcc att aaa aaa aga ctc tgc ata 912 Leu Arg Asn Gln Glu Val Lys Ala Ala Ile Lys Lys Arg Leu Cys Ile 290 295 300 taa 915 305 <210> 632 <211> 304 <212> PRT <213> Homo sapiens <400> 632 Met Glu Arg Ala Asn His Ser Val Val Ser Glu Phe Ile Leu Leu Gly 1 5 10 15 Leu Ser Lys Ser Gln Asn Leu Gln Ile Leu Phe Phe Leu Gly Phe Ser 20 25 30 Val Val Phe Val Gly Ile Val Leu Gly Asn Leu Leu Ile Leu Val Thr 35 40 45 Val Thr Phe Asp Ser Leu Leu His Thr Pro Met Tyr Phe Leu Leu Ser 50 55 60 Asn Leu Ser Cys Ile Asp Met Ile Leu Ala Ser Phe Ala Thr Pro Lys 65 70 75 80 Met Ile Val Asp Phe Leu Arg Glu Arg Lys Thr Ile Ser Trp Trp Gly 85 90 95 Cys Tyr Ser Gln Met Phe Phe Met His Leu Leu Gly Gly Ser Glu Met 100 105 110 Met Leu Leu Val Ala Met Ala Ile Asp Arg Tyr Val Ala Ile Cys Lys 115 120 125 Pro Leu His Tyr Met Thr Ile Met Ser Pro Arg Val Leu Thr Gly Leu 130 135 140 Leu Leu Ser Ser Tyr Ala Val Gly Phe Val His Ser Ser Ser Gln Met 145 150 155 160 Ala Phe Met Leu Thr Leu Pro Phe Cys Gly Pro Asn Val Ile Asp Ser 165 170 175 Phe Phe Cys Asp Leu Pro Leu Val Ile Lys Leu Ala Cys Lys Asp Thr 180 185 190 Tyr Ile Leu Gln Leu Leu Val Ile Ala Asp Ser Gly Leu Leu Ser Leu 195 200 205 Val Cys Phe Leu Leu Leu Leu Val Ser Tyr Gly Val Ile Ile Phe Ser 210 215 220 Val Arg Tyr Arg Ala Ala Ser Arg Ser Ser Lys Ala Phe Ser Thr Leu 225 230 235 240 Ser Ala His Ile Thr Val Val Thr Leu Phe Phe Ala Pro Cys Val Phe 245 250 255 Ile Tyr Val Trp Pro Phe Ser Arg Tyr Ser Val Asp Lys Ile Leu Ser 260 265 270 V al Phe Tyr Thr Ile Phe Thr Pro Leu Leu Asn Pro Ile Ile Tyr Thr 275 280 285 Leu Arg Asn Gln Glu Val Lys Ala Ala Ile Lys Lys Arg Leu Cys Ile 290 295 300 <210> 633 <211> 942 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(942) <400> 633 atg gac agt cta aac caa aca aga gtg act gaa ttt gtc ttc ttg gga 48 Met Asp Ser Leu Asn Gln Thr Arg Val Thr Glu Phe Val Phe Leu Gly 1 5 10 15 ctc act gat aac cgg gtg ctg gaa atg ctg ttt ttc atg gca ttc tca 96 Leu Thr Asp Asn Arg Val Leu Glu Met Leu Phe Phe Met Ala Phe Ser 20 25 30 gcc att tat atg cta acg ctt tca ggg aac att ctc atc atc att gcc 144 Ala Ile Tyr Met Leu Thr Leu Ser Gly Asn Ile Leu Ile Ile Ile Ala 35 40 45 aca gtc ttt act cca agt ctc cat acc ccc atg tat ttc ttc ctg agc 192 Thr Val Phe Thr Pro Ser Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 aat ctg tcc ttt att gac atc tgc cac tca tct gtc act gtg cct aag 240 Asn Leu Ser Phe Ile Asp Ile Cys His Ser Ser Val Thr Val Pro Lys 65 70 75 80 atg ttg gag ggt ttg ctt tta gaa aga aag acc att tcc ttt gac aac 288 Met Leu Glu Gly Leu Leu Leu Glu Arg Lys Thr Ile Ser Phe Asp Asn 85 90 95 tgc atc aca cag ctc ttc ttc cta cat ctc ttt gcc tgt gcc gag atc 336 Cys Ile Thr Gln Leu Phe Phe Leu His Leu Phe Ala Cys Ala Glu Ile 100 105 110 ttt ctg ctg atc att gtg gcg tat gat cgt tac gtg gct atc tgc act 384 Phe Leu Leu Ile Ile Val Ala Tyr Asp Arg Tyr Val Ala Ile Cys Thr 115 120 125 cca ctc cac tac ccc aat gtg atg aac atg aga gtc tgt ata cag ctt 432 Pro Leu His Tyr Pro Asn Val Met Asn Met Arg Val Cys Ile Gln Leu 130 135 140 gtc ttt gct ctc tgg ttg ggg ggt act gtt cac tca cta ggg cag acc 480 Val Phe Ala Leu Trp Leu Gly Gly Thr Val His Ser Leu Gly Gln Thr 145 150 155 160 ttc ttg act att cgt cta cct tac tgt ggc ccc aac att att gac agc 528 Phe Leu Thr Ile Arg Leu Pro Tyr Cys Gly Pro Asn Ile Ile Asp Ser 165 170 175 tac ttc tgt gat gtg cct ctt gtt atc aag ctg gcc tgc aca gat aca 576 Tyr Phe Cys Asp Val Pro Leu Val Ile Lys Leu Ala Cys Thr Asp Thr 180 185 190 tac ctc aca gga ata ctg att gtg acc aat agt gga acc atc tcc ctc 624 Tyr Leu Thr Gly Ile Leu Ile Val Thr Asn Ser Gly Thr Ile Ser Leu 195 200 205 tcc tgt ttc ttg gcc gtg gtc acc tcc tat atg gtc atc ctg gtt tct 672 Ser Cys Phe Leu Ala Val Val Thr Ser Tyr Met Val Ile Leu Val Ser 210 215 220 ctt cga aaa cac tca gct gaa ggg cgc cag aaa gcc ctg tct acc tgc 720 Leu Arg Lys His Ser Ala Glu Gly Arg Gln Lys Ala Leu Ser Thr Cys 22 5 230 235 240 tcg gcc cac ttc atg gtg gtt gcc ctc ttc ttt ggg cca tgt atc ttc 768 Ser Ala His Phe Met Val Val Ala Leu Phe Phe Gly Pro Cys Ile Phe 245 250 255 atc tat act cgg cca gac acc agc ttc tcc att gac aag gtg gtg tct 816 Ile Tyr Thr Arg Pro Asp Thr Ser Phe Ser Ile Asp Lys Val Val Ser 260 265 270 gtc ttc tac aca gtg gtc acc cct ttg ctg aat ccc ttc att tac acc 864 Val Phe Tyr Thr Val Val Thr Pro Leu Leu Asn Pro Phe Ile Tyr Thr 275 280 285 ttg agg aat gag gag gta aaa agt gcc atg aag cag ctc agg cag aga 912 Leu Arg Asn Glu Glu Val Lys Ser Ala Met Lys Gln Leu Arg Gln Arg 290 295 300 caa gtt ttt ttc acg aaa tca tat aca taa 942 Gln Val Phe Phe Thr Lys Ser Tyr Thr 305 310 <210> 634 <211> 313 <212> PRT <213> Homo sapiens <400> 634 Met Asp Ser Leu Asn Gln Thr Arg Val Thr Glu Phe Val Phe Leu Gly 1 5 10 15 Leu Thr Asp Asn Arg Val Leu Glu Met Leu Phe Phe Met Ala Phe Ser 20 25 30 Ala Ile Tyr Met Leu Thr Leu Ser Gly Asn Ile Leu Ile Ile Ile Ala 35 40 45 Thr Val Phe Thr Pro Ser Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Ile Asp Ile Cys His Ser Ser Val Thr Val Pro Lys 65 70 75 80 Met Leu Glu Gly Leu Leu Leu Glu Arg Lys Thr Ile Ser Phe Asp Asn 85 90 95 Cys Ile Thr Gln Leu Phe Phe Leu His Leu Phe Ala Cys Ala Glu Ile 100 105 110 Phe Leu Leu Ile Ile Val Ala Tyr Asp Arg Tyr Val Ala Ile Cys Thr 115 120 125 Pro Leu His Tyr Pro Asn Val Met Asn Met Arg Val Cys Ile Gln Leu 130 135 140 Val Phe Ala Leu Trp Leu Gly Gly Thr Val His Ser Leu Gly Gln Thr 145 150 155 160 Phe Leu Thr Ile Arg Leu Pro Tyr Cys Gly Pro Asn Ile Ile Asp Ser 165 170 175 Tyr Phe Cys Asp Val Pro Leu Val Ile Lys Leu Ala Cys Thr Asp Thr 180 185 190 Tyr Leu Thr Gly Ile Leu Ile Val Thr Asn Ser Gly Thr Ile Ser Leu 195 200 205 Ser Cys Phe Leu Ala Val Val Thr Ser Tyr Met Val Ile Leu Val Ser 210 215 220 Leu Arg Lys His Ser Ala Glu Gly Arg Gln Lys Ala Leu Ser Thr Cys 225 230 235 240 Ser Ala His Phe Met Val Val Ala Leu Phe Phe Gly Pro Cys Ile Phe 245 250 255 Ile Tyr Thr Arg Pro Asp Thr Ser Phe Ser Ile Asp Lys Val Val Ser 260 265 270 Val Phe Tyr Thr Val Val Thr Pro Leu Leu Asn Pro Phe Ile Tyr Thr 275 280 285 Leu Arg Asn Glu Glu Val Lys Ser Ala Met Lys Gln Leu Arg Gln Arg 290 295 300 Gln Val Phe Phe Thr Lys Ser Tyr Thr 305 310 <210> 635 <211> 765 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(765) <400> 635 atg tac atc ttt ctt ggt gtt ctc tca gtc att gat atg agc atc tcc 48 Met Tyr Ile Phe Leu Gly Val Leu Ser Val Ile Asp Met Ser Ile Ser 1 5 10 15 tcc atc att gtc cct cgc ctc atg atg aac ttc act tta ggt gtc aaa 96 Ser Ile Ile Val Pro Arg Leu Met Met Asn Phe Thr Leu Gly Val Lys 20 25 30 ccc atc cca ttt ggt ggc tgt gtt gct caa ctc tat ttc tat cac ttc 144 Pro Ile Pro Phe Gly Gly Cys Val Ala Gln Leu Tyr Phe Tyr His Phe 35 40 45 ctg ggc agc acc cag tgc ttc ctc tac acc cta atg gcc tat gac agg 192 Leu Gly Ser Thr Gln Cys Phe Leu Tyr Thr Leu Met Ala Tyr Asp Arg 50 55 60 tac ctg gca ata tgt cag ccc ctg cgc tac cct gtg ctc atg act gct 240 Tyr Leu Ala Ile Cys Gln Pro Leu Arg Tyr Pro Val Leu Met Thr Ala 65 70 75 80 aag ctg agc gcc ttg ctt gtg gct gga gcc tgg atg gca gga tcc atc 288 Lys Leu Ser Ala Leu Leu Val Ala Gly Ala Trp Met Ala Gly Ser Ile 85 90 95 cat ggg gct ctc cag gcc atc cta acc ttc cgc ctg ccc tac tgt ggg 336 His Gly Ala Leu Gln Ala Ile Leu Thr Phe Arg Leu Pro Tyr Cys Gly 100 105 110 ccc aat cag gtg gat tac ttc ttc tgt gac atc cct gca gtg ttg aga 384 Pro Asn Gln Val Asp Tyr Phe Phe Cys Asp Ile Pro Ala Val Leu Arg 115 120 125 ctg gcc tgt gct gac aca aca gtc aac gag ctg gtg acg ttt gta gac 432 Leu Ala Cys Ala Asp Thr Thr Val Asn Glu Leu Val Thr Phe Val Asp 130 135 140 att ggg gtg gtg gtt gcc agt tgc ttc tcc ctg atc ctc ctc tcc tac 480 Ile Gly Val Val Val Ala Ser Cys Phe Ser Leu Ile Leu Leu Ser Tyr 145 150 155 160 ata cag atc att cag gcc atc ctg aga atc cac aca gct gat ggg cgg 528 Ile Gln Ile Ile Gln Ala Ile Leu Arg Ile His Thr Ala Asp Gly Arg 165 170 175 cgc cgg gct ttt tca act tgt gga gcc cat gta acc gtg gtc acc gtg 576 Arg Arg Ala Phe Ser Thr Cys Gly Ala His Val Thr Val Val Thr Val 180 185 190 tac tat gtg ccc tgt gcc ttc atc tac ctg agg cct gaa acc aac agc 624 Tyr Tyr Val Pro Cys Ala Phe Ile Tyr Leu Arg Pro Glu Thr Asn Ser 195 200 205 ccc ctg gat ggg gca gct gcc cta gtc ccc acg gcc atc act cct ttc 672 Pro Leu Asp Gly Ala Ala Ala Leu Val Pro Thr Ala Ile Thr Pro Phe 210 215 220 ctc aac ccc ctt atc tac act ctg cgg aac caa gag gtg aag ctg gcc 720 Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn Gln Glu Val Lys Leu Ala 225 230 235 240 ctg aaa aga atg ctc aga agc cca aga act ccg agt gag gtt tga 765 Leu Lys Arg Met Leu Arg Ser Pro Arg Thr Pro Ser Glu Val 245 250 255 <210> 636 <211> 254 <212> PRT <213> Homo sapiens <400> 636 Met Tyr Ile Phe Leu Gly Val Leu Ser Val Ile Asp Met Ser Ile Ser 1 5 10 15 Ser Ile Ile Val Pro Arg Leu Met Met Asn Phe Thr Leu Gly Val Lys 20 25 30 Pro Ile Pro Phe Gly Gly Cys Val Ala Gln Leu Tyr Phe Tyr His Phe 35 40 45 Leu Gly Ser Thr Gln Cys Phe Leu Tyr Thr Leu Met Ala Tyr Asp Arg 50 55 60 Tyr Leu Ala Ile Cys Gln Pro Leu Arg Tyr Pro Val Leu Met Thr Ala 65 70 75 80 Lys Leu Ser Ala Leu Leu Val Ala Gly Ala Trp Met Ala Gly Ser Ile 85 90 95 His Gly Ala Leu Gln Ala Ile Leu Thr Phe Arg Leu Pro Tyr Cys Gly 100 105 110 Pro Asn Gln Val Asp Tyr Phe Phe Cys Asp Ile Pro Ala Val Leu Arg 115 120 125 Leu Ala Cys Ala Asp Thr Thr Val Asn Glu Leu Val Thr Phe Val Asp 130 135 140 Ile Gly Val Val Val Ala Ser Cys Phe Ser Leu Ile Leu Leu Ser Tyr 145 150 155 160 Ile Gln Ile Ile Gln Ala Ile Leu Arg Ile His Thr Ala Asp Gly Arg 165 170 175 Arg Arg Ala Phe Ser Thr Cys Gly Ala His Val Thr Val Val Thr Val 180 185 190 Tyr Tyr Val Pro Cys Ala Phe Ile Tyr Leu Arg Pro Glu Thr Asn Ser 195 200 205 Pro Leu Asp Gly Ala Ala Ala Leu Val Pro Thr Ala Ile Thr Pro Phe 210 215 220 Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn Gln Glu Val Lys Leu Ala 225 230 235 240 Leu Lys Arg Met Leu Arg Ser Pro Arg Thr Pro Ser Glu Val 245 250 <210> 637 <211> 888 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(888) <400> 637 atg tac ctg gtc acg gtg ctg agg aac ctg ctc atc atc ctg gct gtc 48 Met Tyr Leu Val Thr Val Leu Arg Asn Leu Leu Ile Ile Leu Ala Val 1 5 10 15 agc tct gac tcc cac ctc cac acc tcc atg tac ttc gtc ctc tcc aac 96 Ser Ser Asp Ser His Leu His Thr Ser Met Tyr Phe Val Leu Ser Asn 20 25 30 ctg cgc tgg gtt gac atc ggt ttc acc tcg gcc acg gtt ccc aag atg 144 Leu Arg Trp Val Asp Ile Gly Phe Thr Ser Ala Thr Val Pro Lys Met 35 40 45 att gtg gac atg cag tcg cat agc aga gtc atc tct tat gcg ggc tgc 192 Ile Val Asp Met Gln Ser His Ser Arg Val Ile Ser Tyr Ala Gly Cys 50 55 60 ctg aca cag atg tct ttc ttg gtc ttt ttt gca tgt ata gaa gac atg 240 Leu Thr Gln Met Ser Phe Leu Val Phe Phe Ala Cys Ile Glu Asp Met 65 70 75 80 ctc ctg act gtg atg tcc tat gac caa ttt ttg gcc atc tgt cac ccc 288 Leu Leu Thr Val Met Ser Tyr Asp Gln Phe Leu Ala Ile Cys His Pro 85 90 95 ctg cac tac cca gtc atc gtg aat cct cac ttc tgt gtc ttc tta gtt 336 Leu His Tyr Pro Val Ile Val Asn Pro His Phe Cys Val Phe Leu Val 100 105 110 ttg gtg tcc ttt ttc ctt agc ctg ttg gat tcc cag ctg cat aga tgg 384 Leu Val Ser Phe Phe Leu Ser Leu Leu Asp Ser Gln Leu His Arg Trp 115 120 125 att gtg tta caa ttc acc ttc ttc aag aat gtg gaa atc tct aat ttt 432 Ile Val Leu Gln Phe Thr Phe Phe Lys Asn Val Glu Ile Ser Asn Phe 130 135 140 gtc tgt gag cca tct caa ctt ctc aac ctt gcc tgt tct gac agc gtc 480 Val Cys Glu Pro Ser Gln Leu Leu Asn Leu Ala Cys Ser Asp Ser Val 145 150 155 160 atc aat atc ata ttc ata tat tta gat agt act atg ttt ggt ttt ctt 528 Ile Asn Ile Ile Phe Ile Tyr Leu Asp Ser Thr Met Phe Gly Phe Leu 165 170 175 ccc att tca ggg atc ctt ttg tct tac tat aaa att gtc ccc tcc att 576 Pro Ile Ser Gly Ile Leu Leu Ser Tyr Tyr Lys Ile Val Pro Ser Ile 180 185 190 cta agg atg tca ttg tca gat gtg aag tat aaa gcc ttc tcc acc tgt 624 Leu Arg Met Ser Leu Ser Asp Val Lys Tyr Lys Ala Phe Ser Thr Cys 195 200 205 ggc tct cac ctg gca gtt ttt tgc tta ttt tac gga gca ggc att ggc 672 Gly Ser His Leu Ala Val Phe Cys Leu Phe Tyr Gly Ala Gly Ile Gly 210 215 220 gtg tac ctg act tca gct gtg tca cca cct tcc ggc aat ggt gtg gtg 720 Val Tyr Leu Thr Ser Ala Val Ser Pro Pro Ser Gly Asn Gly Val Val 225 230 235 240 gct tca gtg atg tac act gtg gtc acc ccc atg ctg aac cct ttc atc 768 Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe Ile 245 250 255 tac agc ctg aga aac agg gac att caa agt gcc ccg tgg agg ctg cgc 816 Tyr Ser Leu Arg Asn Arg Asp Ile Gln Ser Ala Pro Trp Arg Leu Arg 260 265 270 agc aca aca gtt gaa tct cat gat ctc ttc cat cct ttt tct tgt gtc 864 Ser Thr Thr Val Glu Ser His Asp Leu Phe His Pro Phe Ser Cys Val 275 280 285 tgt aag aaa ggg caa cca cat taa 888 Cys Lys Lys Gly Gln Pro His 290 295 <210> 638 <211> 295 <212> PRT <213> Homo sapiens <400> 638 Met Tyr Leu Val Thr Val Leu Arg Asn Leu Leu Ile Ile Leu Ala Val 1 5 10 15 Se r Ser Asp Ser His Leu His Thr Ser Met Tyr Phe Val Leu Ser Asn 20 25 30 Leu Arg Trp Val Asp Ile Gly Phe Thr Ser Ala Thr Val Pro Lys Met 35 40 45 Ile Val Asp Met Gln Ser His Ser Arg Val Ile Ser Tyr Ala Gly Cys 50 55 60 Leu Thr Gln Met Ser Phe Leu Val Phe Phe Ala Cys Ile Glu Asp Met 65 70 75 80 Leu Leu Thr Val Met Ser Tyr Asp Gln Phe Leu Ala Ile Cys His Pro 85 90 95 Leu His Tyr Pro Val Ile Val Asn Pro His Phe Cys Val Phe Leu Val 100 105 110 Leu Val Ser Phe Phe Leu Ser Leu Leu Asp Ser Gln Leu His Arg Trp 115 120 125 Ile Val Leu Gln Phe Thr Phe Phe Lys Asn Val Glu Ile Ser Asn Phe 130 135 140 Val Cys Glu Pro Ser Gln Leu Leu Asn Leu Ala Cys Ser Asp Ser Val 145 150 155 160 Ile Asn Ile Ile Phe Ile Tyr Leu Asp Ser Thr Met Phe Gly Phe Leu 165 170 175 Pro Ile Ser Gly Ile Leu Leu Ser Tyr Tyr Lys Ile Val Pro Ser Ile 180 185 190 Leu Arg Met Ser Leu Ser Asp Val Lys Tyr Lys Ala Phe Ser Thr Cys 195 200 205 Gly Ser His Leu Ala Val Phe Cys Leu Phe Tyr Gly Ala Gly Ile Gly 210 215 220 Val Tyr Leu Thr Ser Ala Val Ser Pro Pro Ser Gly Asn Gly Val Val 225 230 235 240 Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe Ile 245 250 255 Tyr Ser Leu Arg Asn Arg Asp Ile Gln Ser Ala Pro Trp Arg Leu Arg 260 265 270 Ser Thr Thr Val Glu Ser His Asp Leu Phe His Pro Phe Ser Cys Val 275 280 285 Cys Lys Lys Gly Gln Pro His 290 295 <210> 639 <211> 981 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(981) <400> 639 atg tgt ccc ttg acc ttg cag gtc act ggc cta atg aat gtc tct gag 48 Met Cys Pro Leu Thr Leu Gln Val Thr Gly Leu Met Asn Val Ser Glu 1 5 10 15 cca aat tcc agc ttt gct ttt gta aat gaa ttt ata ctc caa ggt ttc 96 Pro Asn Ser Ser Phe Ala Phe Val Asn Glu Phe Ile Leu Gln Gly Phe 20 25 30 tct tgt gag tgg aca att cag atc ttc ctc ttc tca ctc ttt act aca 144 Ser Cys Glu Trp Thr Ile Gln Ile Phe Leu Phe Ser Leu Phe Thr Thr 35 40 45 aca tat gca ctg act ata aca ggg aat gga gcc att gct ttt gtc ctg 192 Thr Tyr Ala Leu Thr Ile Thr Gly Asn Gly Ala Ile Ala Phe Val Leu 50 55 60 tgg tgt gac cgg cga ctt cac act ccc atg tac atg ttc ctg gga aat 240 Trp Cys Asp Arg Arg Leu His Thr Pro Met Tyr Met Phe Leu Gly Asn 65 70 75 80 ttc tcc ttt tta gag ata tgg tat gtc tct tct aca gtt ccc aag atg 288 Phe Ser Phe Leu Glu Ile Trp Tyr Val Ser Ser Thr Val Pro Lys Met 85 90 95 ttg gtc aac ttc ctt tca gag aaa aaa aac atc tcc ttt gct gga tgt 336 Leu Val Asn Phe Leu Ser Glu Lys Lys Asn Ile Ser Phe Ala Gly Cys 100 105 110 ttt ctc cag ttt tat ttc ttc ttc tct ttg ggt aca tca gaa tgc ttg 384 Phe Leu Gln Phe Tyr Phe Phe Phe Ser Leu Gly Thr Ser Glu Cys Leu 115 120 125 ctt ttg act gtg atg gcc ttt gat cag tac ctt gct atc tgc cgt ccc 432 Leu Leu Thr Val Met Ala Phe Asp Gln Tyr Leu Ala Ile Cys Arg Pro 130 135 140 ttg ctc tat cct aat atc atg act ggg cat ctc tat gcc aaa ctg gtc 480 Leu Leu Tyr Pro Asn Ile Met Thr Gly His Leu Tyr Ala Lys Leu Val 145 150 155 160 ata ctg tgc tgg gtt tgt gga ttt ctg tgg ttc ctg atc ccc att gtt 528 Ile Leu Cys Trp Val Cys Gly Phe Leu Trp Phe Leu Ile Pro Ile Val 165 170 175 ctc atc tct cag atg ccc ttc tgt ggc cca aac att att gac cat gtt 576 Leu Ile Ser Gln Met Pro Phe Cys Gly Pro Asn Ile Ile Asp His Val 180 185 190 gtg tgt gac cca ggg cca cga ttt gca ttg gat tgt gtt tct gcc cca 624 Val Cys Asp Pro Gly Pro Arg Phe Ala Leu Asp Cys Val Ser Ala Pro 195 200 205 aga atc caa ctg ttt tgc tac act cta agc tca tta gtt att ttt ggt 672 Arg Ile Gln Leu Phe Cys Tyr Thr Leu Ser Ser Leu Val Ile Phe Gly 210 215 220 aac ttc ctc ttt att att gga tcc tat act ctt gtc ctg aaa gct atg 720 Asn Phe Leu Phe Ile Ile Gly Ser Tyr Thr Leu Val Leu Lys Ala Met 225 230 235 240 ttg ggt atg cct tca agc act ggg aga cat aag gcc ttc tct acc tgt 768 Leu Gly Met Pro Ser Ser Thr Gly Arg His Lys Ala Phe Ser Thr Cys 245 250 255 ggg tct cat ttg gct gtg gta tca ctg tgc tat agc tct ctt atg gtc 816 Gly Ser His Leu Ala Val Val Ser Leu Cys Tyr Ser Ser Leu Met Val 260 265 270 atg tat gtg agc cca gga ctc gga cat tct aca ggg atg cag aaa att 864 Met Tyr Val Ser Pro Gly Leu Gly His Ser Thr Gly Met Gln Lys Ile 275 280 285 gaa act ttg ttc tat gct atg gtg acc cca ctc ttc aat ccc ctt atc 912 Glu Thr Leu Phe Tyr Ala Met Val Thr Pro Leu Phe Asn Pro Leu Ile 290 295 300 tat agc ctc cag aat aag gag ata aag gca gcc ctg agg aaa gtt ctg 960 Tyr Ser Leu Gln Asn Lys Glu Ile Lys Ala Ala Leu Arg Lys Val Leu 305 310 315 320 ggg agt tcc aac ata atc taa 981 Gly Ser Ser Asn Ile Ile 325 <210> 640 <21 1> 326 <212> PRT <213> Homo sapiens <400> 640 Met Cys Pro Leu Thr Leu Gln Val Thr Gly Leu Met Asn Val Ser Glu 1 5 10 15 Pro Asn Ser Ser Phe Ala Phe Val Asn Glu Phe Ile Leu Gln Gly Phe 20 25 30 Ser Cys Glu Trp Thr Ile Gln Ile Phe Leu Phe Ser Leu Phe Thr Thr 35 40 45 Thr Tyr Ala Leu Thr Ile Thr Gly Asn Gly Ala Ile Ala Phe Val Leu 50 55 60 Trp Cys Asp Arg Arg Leu His Thr Pro Met Tyr Met Phe Leu Gly Asn 65 70 75 80 Phe Ser Phe Leu Glu Ile Trp Tyr Val Ser Ser Thr Val Pro Lys Met 85 90 95 Leu Val Asn Phe Leu Ser Glu Lys Lys Asn Ile Ser Phe Ala Gly Cys 100 105 110 Phe Leu Gln Phe Tyr Phe Phe Phe Ser Leu Gly Thr Ser Glu Cys Leu 115 120 125 Leu Leu Thr Val Met Ala Phe Asp Gln Tyr Leu Ala Ile Cys Arg Pro 130 135 140 Leu Leu Tyr Pro Asn Ile Met Thr Gly His Leu Tyr Ala Lys Leu Val 145 150 155 160 Ile Leu Cys Trp Val Cys Gly Phe Leu Trp Phe Leu Ile Pro Ile Val 165 170 175 Leu Ile Ser Gln Met Pro Phe Cys Gly Pro Asn Ile Ile Asp His Val 180 185 190 Val Cys Asp Pro Gly Pro Arg Phe Ala Leu Asp Cys Val Ser Ala Pro 195 200 205 Arg Ile Gln Leu Phe Cys Tyr Thr Leu Ser Ser Leu Val Ile Phe Gly 210 215 220 Asn Phe Leu Phe Ile Ile Gly Ser Tyr Thr Leu Val Leu Lys Ala Met 225 230 235 240 Leu Gly Met Pro Ser Ser Thr Gly Arg His Lys Ala Phe Ser Thr Cys 245 250 255 Gly Ser His Leu Ala Val Val Ser Leu Cys Tyr Ser Ser Leu Met Val 260 265 270 Met Tyr Val Ser Pro Gly Leu Gly His Ser Thr Gly Met Gln Lys Ile 275 280 285 Glu Thr Leu Phe Tyr Ala Met Val Thr Pro Leu Phe Asn Pro Leu Ile 290 295 300 Tyr Ser Leu Gln Asn Lys Glu Ile Lys Ala Ala Leu Arg Lys Val Leu 305 310 315 320 Gly Ser Ser Asn Ile Ile 325 <210> 641 <211> 1038 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1038) <400> 641 atg ccg atg cag ctg ctg ctt aca gat ttt att atc ttt tcc atc aga 48 Met Pro Met Gln Leu Leu Leu Thr Asp Phe Ile Ile Phe Ser Ile Arg 1 5 10 15 ttc atc atc aac agc atg gaa gcg aga aac caa aca gct att tca aaa 96 Phe Ile Ile Asn Ser Met Glu Ala Arg Asn Gln Thr Ala Ile Ser Lys 20 25 30 ttc ctt ctc ctg gga ctg ata gag gat ccg gaa ctg cag ccc gtc ctt 144 Phe Leu Leu Leu Gly Leu Ile Glu Asp Pro Glu Leu Gln Pro Val Leu 35 40 45 ttc agc ctg ttc ctg tcc atg tac ttg gtc acc atc ctg ggg aac ctg 192 Phe Ser Leu Phe Leu Ser Met Tyr Leu Val Thr Ile Leu Gly Asn Leu 50 55 60 ctc atc ctc ttg gct gtc atc tct gac tct cac ctc cac acc ccc atg 240 Leu Ile Leu Leu Ala Val Ile Ser Asp Ser His Leu His Thr Pro Met 65 70 75 80 tac ttc ttc ctc tcc aat ctc tcc ttt ttg gac att tgt tta agc aca 288 Tyr Phe Phe Leu Ser Asn Leu Ser Phe Leu Asp Ile Cys Leu Ser Thr 85 90 95 acc acg atc cca aag atg ctg gtg aac atc caa gct cag aat cgg agc 336 Thr Thr Ile Pro Lys Met Leu Val Asn Ile Gln Ala Gln Asn Arg Ser 100 105 110 atc acg tac tca ggc tgc ctc acc cag atc tgc ttt gtc ttg ttt ttt 384 Ile Thr Tyr Ser Gly Cys Leu Thr Gln Ile Cys Phe Val Leu Phe Phe 115 120 125 gct ggc ttg gaa aat tgt ctc ctt gca gca atg gcc tat gac cgc tat 432 Ala Gly Leu Glu Asn Cys Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr 130 135 140 gtg gcc att tgt cac ccc ctt aga tac aca gtc atc atg aac ccc cgc 480 Val Ala Ile Cys His Pro Leu Arg Tyr Thr Val Ile Met Asn Pro Arg 145 150 155 160 ctc tgt ggc ctg ctg att ctt ctc tct ctg ttg act agt gtt gtg aat 528 Leu Cys Gly Leu Leu Ile Leu Leu Ser Leu Leu Thr Ser Val Val Asn 165 170 175 gcc ctt ctt ctc agc ctg atg gtg ttg agg ctg tcc ttc tgc aca gac 576 Ala Leu Leu Leu Ser Leu Met Val Leu Arg Leu Ser Phe Cys Thr Asp 180 185 190 ctg gaa atc ccg ctc ttc ttc tgt gaa ctg gct cag gtc atc caa ctc 624 Leu Glu Ile Pro Leu Phe Phe Cys Glu Leu Ala Gln Val Ile Gln Leu 195 200 205 acc tgt tca gac acc ctc atc aat aac atc ctg ata tat ttt gca gct 672 Thr Cys Ser Asp Thr Leu Ile Asn Asn Ile Leu Ile Tyr Phe Ala Ala 210 215 220 tgc ata ttt ggt ggt gtt cct ctg tct gga atc att ttg tct tac act 720 Cys Ile Phe Gly Gly Val Pro Leu Ser Gly Ile Ile Leu Ser Tyr Thr 225 230 235 240 cag atc acc tcc tgt gtt ttg aga atg cca tca gca agt gga aag cac 768 Gln Ile Thr Ser Cys Val Leu Arg Met Pro Ser Ala Ser Gly Lys His 245 250 255 aaa gca gtt tcc acc tgt ggg tct cac ctc tcc att gtt ctc ttg ttc 816 Lys Ala Val Ser Thr Cys Gly Ser His Leu Ser Ile Val Leu Leu Phe 260 265 270 tat ggg gca ggt ttg ggg gtg tac att agt tct gtg gtt act gac tca 864 Tyr Gly Ala Gly Leu Gly Val Tyr Ile Ser Ser Val Val Thr Asp Ser 275 280 285 cct agg aag act gca gtg gct tca gtg atg tat tct gtg ttc cct caa 912 Pro Arg Lys Thr Ala Val Ala Ser Val Met Tyr Ser Val Phe Pro Gln 290 295 300 atg gtg aac ccc ttt atc tat agt ctg agg aat aag gac atg aaa gga 960 Met Val Asn Pro Phe Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys Gly 305 310 315 320 acc ttg agg aag ttc ata ggg agg ata cct tct ctt ctg tgg tgt gcc 1008 Thr Leu Arg Lys Phe Ile Gly Arg Ile Pro Ser Leu Leu Trp Cys Ala 325 330 335 att tgc ttt gga ttc agg ttt cta gag taa 1038 Ile Cys Phe Gly Phe Arg Phe Leu Glu 340 345 <210> 642 <211> 345 <212> PRT <213> Homo sapiens <400> 642 Met Pro Met Gln Leu Leu Leu Thr Asp Phe Ile Ile Phe Ser Ile Arg 1 5 10 15 Phe Ile Ile Asn Ser Met Glu Ala Arg Asn Gln Thr Ala Ile Ser Lys 20 25 30 Phe Leu Leu Leu Gly Leu Ile Glu Asp Pro Glu Leu Gln Pro Val Leu 35 40 45 Phe Ser Leu Phe Leu Ser Met Tyr Leu Val Thr Ile Leu Gly Asn Leu 50 55 60 Leu Ile Leu Leu Ala Val Ile Ser Asp Ser His Leu His Thr Pro Met 65 70 75 80 Tyr Phe Phe Leu Ser Asn Leu Ser Phe Leu Asp Ile Cys Leu Ser Thr 85 90 95 Thr Thr Ile Pro Lys Met Leu Val Asn Ile Gln Ala Gln Asn Arg Ser 100 105 110 Ile Thr Tyr Ser Gly Cys Leu Thr Gln Ile Cys Phe Val Leu Phe Phe 115 120 125 Ala Gly Leu Glu Asn Cys Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr 130 135 140 Val Ala Ile Cys His Pro Leu Arg Tyr Thr Val Ile Met Asn Pro Arg 145 150 155 160 Leu Cys Gly Leu Leu Ile Leu Leu Ser Leu Leu Thr Ser Val Val Asn 165 170 175 Ala Leu Leu Leu Ser Leu Met Val Leu Arg Leu Ser Phe Cys Thr Asp 180 185 190 Leu Glu Ile Pro Leu Phe Phe Cys Glu Leu Ala Gln Val Ile Gln Leu 195 200 205 Thr Cys Ser Asp Thr Leu Ile Asn Asn Ile Leu Ile Tyr Phe Ala Ala 210 215 220 Cys Ile Phe Gly Gly Val Pro Leu Ser Gly Ile Ile Leu Ser Tyr Thr 225 230 235 240 Gln Ile Thr Ser Cys Val Leu Arg Met Pro Ser Ala Ser Gly Lys His 245 250 255 Lys Ala Val Ser Thr Cys Gly Ser His Leu Ser Ile Val Leu Leu Phe 260 265 270 Tyr Gly Ala Gly Leu Gly Val Tyr Ile Ser Ser Val Val Thr Asp Ser 275 280 285 Pro Arg Lys Thr Ala Val Ala Ser Val Met Tyr Ser Val Phe Pro Gln 290 295 300 Met Val Asn Pro Phe Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys Gly 305 310 315 320 Thr Leu Arg Lys Phe Ile Gly Arg Ile Pro Ser Leu Leu Trp Cys Ala 325 330 335 Ile Cys Phe Gly Phe Arg Phe Leu Glu 340 345 <210> 643 <211> 939 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(939) <400> 643 atg aaa gca gga aac ttc tca gac act cca gaa ttc ttt ctc ttg gga 48 Met Lys Ala Gly Asn Phe Ser Asp Thr Pro Glu Phe Phe Leu Leu Gly 1 5 10 15 ttg tca ggg gat ccg gag ctg cag ccc atc ctc ttc atg ctg ttc ctg 96 Leu Ser Gly Asp Pro Glu Leu Gln Pro Ile Leu Phe Met Leu Phe Leu 20 25 30 tcc atg tac ctg gcc aca atg ctg ggg aac ctg ctc atc atc ctg gcc 144 Ser Met Tyr Leu Ala Thr Met Leu Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 gtc aac tct gac tcc cac ctc cac acc ccc atg tac ttc ctc ctc tct 192 Val Asn Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Leu Leu Ser 50 55 60 atc ctg tcc ttg gtc gac atc tgt ttc acc tcc acc acg atg ccc aag 240 Ile Leu Ser Leu Val Asp Ile Cys Phe Thr Ser Thr Thr Met Pro Lys 65 70 75 80 atg ctg gtg aac atc cag gca cag gct caa tcc atc aat tac aca ggc 288 Met Leu Val Asn Ile Gln Ala Gln Ala Gln Ser Ile Asn Tyr Thr Gly 85 90 95 tgc ctc acc caa atc tgc ttt gtc ctg gtt ttt gtt gga ttg gaa aat 336 Cys Leu Thr Gln Ile Cys Phe Val Leu Val Phe Val Gly Leu Glu Asn 100 105 110 gga att ctg gtc atg atg gcc tat gat cga ttt gtg gcc atc tgt cac 384 Gly Ile Leu Val Met Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125 cca ctg agg tac aat gtc atc atg aac ccc aaa ctc tgt ggg ctg ctg 432 Pro Leu Arg Tyr Asn Val Ile Met Asn Pro Lys Leu Cys Gly Leu Leu 130 135 140 ctt ctg ctg tcc ttc atc gtt agt gtc ctg gat gct ctg ctg cac acg 480 Leu Leu Leu Ser Phe Ile Val Ser Val Leu Asp Ala Leu Leu His Thr 145 150 155 160 ttg atg gtg cta cag ctg acc ttc tgc ata gac ctg gaa att ccc cac 528 Leu Met Val Leu Gln Leu Thr Phe Cys Ile Asp Leu Glu Ile Pro His 165 170 175 ttt ttc tgt gaa cta gct cat att ctc aag ctc gcc tgt tct gat gtc 576 Phe Phe Cys Glu Leu Ala His Ile Leu Lys Leu Ala Cys Ser Asp Val 180 185 190 ctc atc aat aac atc ctg gtg tat ttg gtg acc agc ctg tta ggt gtt 624 Leu Ile Asn Asn Ile Leu Val Tyr Leu Val Thr Ser Leu Leu Gly Val 195 200 205 gtt cct ctc tct ggg atc att ttc tct tac aca cga att gtc tcc tct 672 Val Pro Leu Ser Gly Ile Ile Phe Ser Tyr Thr Arg Ile Val Ser Ser 210 215 220 gtc atg aaa att cca tca gct ggt gga aag tat aaa gct ttt tcc atc 720 Val Met Lys Ile Pro Ser Ala Gly Gly Lys Tyr Lys Ala Phe Ser Ile 225 230 235 240 tgc ggg tca cat tta atc gtt gtt tcc ttg ttt tat gga aca ggg ttt 768 Cys Gly Ser His Leu Ile Val Val Ser Leu Phe Tyr Gly Thr Gly Phe 245 250 255 ggg gtg tac ctt agt tct ggg gct acc cac tcc tcc agg aag ggt gca 816 Gly Val Tyr Leu Ser Ser Gly Ala Thr His Ser Ser Arg Lys Gly Ala 260 265 270 ata gca tca gtg atg tat acc gtg gtc acc ccc atg ctg aac cca ctc 864 Ile Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Leu 275 280 285 att tac agc ctg aga aac aag gac atg ttg aag gct ttg agg aaa cta 912 Ile Tyr Ser Leu Arg Asn Lys Asp Met Leu Lys Ala Leu Arg Lys Leu 290 295 300 ata tct agg ata cca tct ttc cat tga 939 Ile Ser Arg Ile Pro Ser Phe His 305 310 <210> 644 <211> 312 <212> PRT <213> Homo sapiens <400> 644 Met Lys Ala Gly Asn Phe Ser Asp Thr Pro Glu Phe Phe Leu Leu Gly 1 5 10 15 Leu Ser Gly Asp Pro Glu Leu Gln Pro Ile Leu Phe Met Leu Phe Leu 20 25 30 Ser Met Tyr Leu Ala Thr Met Leu Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Val Asn Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Leu Leu Ser 50 55 60 Ile Leu Ser Leu Val Asp Ile Cys Phe Thr Ser Thr Thr Met Pro Lys 65 70 75 80 Met Leu Val Asn Ile Gln Ala Gln Ala Gln Ser Ile Asn Tyr Thr Gly 85 90 95 Cys Leu Thr Gln Ile Cys Phe Val Leu Val Phe Val Gly Leu Glu Asn 100 105 110 Gly Ile Leu Val Met Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125 Pro Leu Arg Tyr Asn Val Ile Met Asn Pro Lys Leu Cys Gly Leu Leu 130 135 140 Leu Leu Leu Ser Phe Ile Val Ser Val Leu Asp Ala Leu Leu His Thr 145 150 155 160 Leu Met Val Leu Gln Leu Thr Phe Cys Ile Asp Leu Glu Ile Pro His 165 170 175 Phe Phe Cys Glu Leu Ala His Ile Leu Lys Leu Ala Cys Ser Asp Val 180 185 190 Leu Ile Asn Asn Ile Leu Val Tyr Leu Val Thr Ser Leu Leu Gly Val 195 200 205 Val Pro Leu Ser Gly Ile Ile Phe Ser Tyr Thr Arg Ile Val Ser Ser 210 215 220 Val Met Lys Ile Pro Ser Ala Gly Gly Lys Tyr Lys Ala Phe Ser Ile 225 230 235 240 Cys Gly Ser His Leu Ile Val Val Ser Leu Phe Tyr Gly Thr Gly Phe 245 250 255 Gly Val Tyr Leu Ser Ser Gly Ala Thr His Ser Ser Arg Lys Gly Ala 260 265 270 Ile Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Met Leu Lys Ala Leu Arg Lys Leu 290 295 300 Ile Ser Arg Ile Pro Ser Phe His 305 310 <210> 645 <211> 936 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(936) <400> 645 atg gga ccc aga aac caa aca gct gtt tca gaa ttt ctt ctc atg aaa 48 Met Gly Pro Arg Asn Gln Thr Ala Val Ser Glu Phe Leu Leu Met Lys 1 5 10 15 gtg aca gag gac cca gaa ctg aag tta atc cct ttc agc ctg ttc ctg 96 Val Thr Glu Asp Pro Glu Leu Lys Leu Ile Pro Phe Ser Leu Phe Leu 20 25 30 tcc atg tac ctg gtc acc atc ctg ggg aac ctg ctc att ctc ctg gct 144 Se r Met Tyr Leu Val Thr Ile Leu Gly Asn Leu Leu Ile Leu Leu Ala 35 40 45 gtc atc tct gac tcc cac ctc cac acc ccc atg tac ttc ctt ctc ttt 192 Val Ile Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Leu Leu Phe 50 55 60 aat ctc tcc ttt act gac atc tgt tta acc aca acc aca gtc cca aag 240 Asn Leu Ser Phe Thr Asp Ile Cys Leu Thr Thr Thr Thr Val Pro Lys 65 70 75 80 atc cta gtg aac atc caa gct cag aat cag agt atc act tac aca ggc 288 Ile Leu Val Asn Ile Gln Ala Gln Asn Gln Ser Ile Thr Tyr Thr Gly 85 90 95 tgc ctc acc cag atc tgt ctt gtc ttg gtt ttt gct ggc ttg gaa agt 336 Cys Leu Thr Gln Ile Cys Leu Val Leu Val Phe Ala Gly Leu Glu Ser 100 105 110 tgc ttt ctt gca gtc atg gcc tac gac cgc tat gtg gcc att tgc cac 384 Cys Phe Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 cca ctg agg tac aca gtc ctc atg aat gtc cat ttc tgg ggc ttg ctg 432 Pro Leu Arg Tyr Thr Val Leu Met Asn Val His Phe Trp Gly Leu Leu 130 135 140 att ctt ctc tcc atg ttc atg agc act atg gat gcc ctg gtt cag agt 480 Ile Leu Leu Ser Met Phe Met Ser Thr Met Asp Ala Leu Val Gln Ser 145 150 155 160 ctg atg gta ttg cag ctg tcc ttc tgc aaa aac gtt gaa atc cct ttg 528 Leu Met Val Leu Gln Leu Ser Phe Cys Lys Asn Val Glu Ile Pro Leu 165 170 175 ttc ttc tgt gaa gtc gtt cag gtc atc aag ctc gcc tgt tct gac acc 576 Phe Phe Cys Glu Val Val Gln Val Ile Lys Leu Ala Cys Ser Asp Thr 180 185 190 ctc atc aac aac atc ctc ata tat ttt gca agt agt gta ttt ggt gca 624 Leu Ile Asn Asn Ile Leu Ile Tyr Phe Ala Ser Ser Val Phe Gly Ala 195 200 205 att cct ctc tct gga ata att ttc tct tat tct caa ata gtc acc tct 672 Ile Pro Leu Ser Gly Ile Ile Phe Ser Tyr Ser Gln Ile Val Thr Ser 210 215 220 gtt ctg aga atg cca tca gca aga gga aag tat aaa gcg ttt tcc acc 720 Val Leu Arg Met Pro Ser Ala Arg Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 tgt ggc tgt cac ctc tct gtt ttt tcc ttg ttc tat ggg aca gct ttt 768 Cys Gly Cys His Leu Ser Val Phe Ser Leu Phe Tyr Gly Thr Ala Phe 245 250 255 ggg gtg tac att agt tct gct gtt gct gag tct tcc cga att act gct 816 Gly Val Tyr Ile Ser Ser Ala Val Ala Glu Ser Ser Arg Ile Thr Ala 260 265 270 gtg gct tca gtg atg tac act gtg gtc cct caa atg atg aac ccc ttc 864 Val Ala Ser Val Met Tyr Thr Val Val Pro Gln Met Met Asn Pro Phe 275 280 285 atc tac agc ctg aga aat aag gag atg aag aaa gct ttg agg aaa ctt 912 Ile Tyr Ser Leu Arg Asn Lys Glu Met Lys Lys Ala Leu Arg Lys Leu 290 295 300 att ggt agg ctg ttt cct ttt tag 936 Ile Gly Arg Leu Phe Pro Phe 305 310 <210> 646 <211> 311 <212> PRT <213> Homo sapiens <400> 646 Met Gly Pro Arg Asn Gln Thr Ala Val Ser Glu Phe Leu Leu Met Lys 1 5 10 15 Val Thr Glu Asp Pro Glu Leu Lys Leu Ile Pro Phe Ser Leu Phe Leu 20 25 30 Ser Met Tyr Leu Val Thr Ile Leu Gly Asn Leu Leu Ile Leu Leu Ala 35 40 45 Val Ile Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Leu Leu Phe 50 55 60 As n Leu Ser Phe Thr Asp Ile Cys Leu Thr Thr Thr Thr Val Pro Lys 65 70 75 80 Ile Leu Val Asn Ile Gln Ala Gln Asn Gln Ser Ile Thr Tyr Thr Gly 85 90 95 Cys Leu Thr Gln Ile Cys Leu Val Leu Val Phe Ala Gly Leu Glu Ser 100 105 110 Cys Phe Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu Arg Tyr Thr Val Leu Met Asn Val His Phe Trp Gly Leu Leu 130 135 140 Ile Leu Leu Ser Met Phe Met Ser Thr Met Asp Ala Leu Val Gln Ser 145 150 155 160 Leu Met Val Leu Gln Leu Ser Phe Cys Lys Asn Val Glu Ile Pro Leu 165 170 175 Phe Phe Cys Glu Val Val Gln Val Ile Lys Leu Ala Cys Ser Asp Thr 180 185 190 Leu Ile Asn Asn Ile Leu Ile Tyr Phe Ala Ser Ser Val Phe Gly Ala 195 200 205 Ile Pro Leu Ser Gly Ile Ile Phe Ser Tyr Ser Gln Ile Val Thr Ser 210 215 220 Val Leu Arg Met Pro Ser Ala Arg Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Cys His Leu Ser Val Phe Ser Leu Phe Tyr Gly Thr Ala Phe 245 250 255 Gly Val Tyr Ile Ser Ser Ala Val Ala Glu Ser Ser Arg Ile Thr Ala 260 265 270 Val Ala Ser Val Met Tyr Thr Val Val Pro Gln Met Met Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Met Lys Lys Ala Leu Arg Lys Leu 290 295 300 Ile Gly Arg Leu Phe Pro Phe 305 310 <210> 647 <211> 942 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(942) <400> 647 atg gaa cca aga aac caa acc agt gca tct caa ttc atc ctc ctg gga 48 Met Glu Pro Arg Asn Gln Thr Ser Ala Ser Gln Phe Ile Leu Leu Gly 1 5 10 15 ctc tca gaa aag cca gag cag gag acg ctt ctc ttt tcc ctg ttc ttc 96 Leu Ser Glu Lys Pro Glu Gln Glu Thr Leu Leu Phe Ser Leu Phe Phe 20 25 30 tgc atg tac ctg gtc atg gtc gtg ggg aac ctg ctc atc atc ctg gcc 144 Cys Met Tyr Leu Val Met Val Val Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 at c agc ata gac tcc cac ctc cac acc ccc atg tac ttc ttc ctg gcc 192 Ile Ser Ile Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 aac ctg tcc ctg gtt gat ttc tgt ctg gcc acc aac acc atc cct aag 240 Asn Leu Ser Leu Val Asp Phe Cys Leu Ala Thr Asn Thr Ile Pro Lys 65 70 75 80 atg ctg gtg agc ctt caa acc ggg agc aag gcc atc tct tat ccc tgc 288 Met Leu Val Ser Leu Gln Thr Gly Ser Lys Ala Ile Ser Tyr Pro Cys 85 90 95 tgc ctg atc cag atg tac ttc ttc cat ttc ttt ggc atc gtg gac agc 336 Cys Leu Ile Gln Met Tyr Phe Phe His Phe Phe Gly Ile Val Asp Ser 100 105 110 gtc ata atc gcc atg atg gct tat gac cgg ttc gtg gcc atc tgc cac 384 Val Ile Ile Ala Met Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125 cca ttg cac tac gcc aag atc atg agc cta cgc ctc tgt cgc ctg ctg 432 Pro Leu His Tyr Ala Lys Ile Met Ser Leu Arg Leu Cys Arg Leu Leu 130 135 140 gtc ggc gcc ctc tgg gcg ttt tcc tgc ttc atc tca ctc act cac atc 480 Val Gly Ala Leu Trp Ala Phe Ser Cys Phe Ile Ser Leu Thr His Ile 145 150 155 160 ctc ctg atg gcc cgt ctc gtt ttc tgc ggc agc cat gag gtg cct cac 528 Leu Leu Met Ala Arg Leu Val Phe Cys Gly Ser His Glu Val Pro His 165 170 175 tac ttc tgc gac ctc act ccc atc ctc cga ctt tcg tgc acg gac acc 576 Tyr Phe Cys Asp Leu Thr Pro Ile Leu Arg Leu Ser Cys Thr Asp Thr 180 185 190 tct gtg aat agg atc ttc atc ctc att gtg gca ggg atg gtg ata gcc 624 Ser Val Asn Arg Ile Phe Ile Leu Ile Val Ala Gly Met Val Ile Ala 195 200 205 acg ccc ttt gtc tgc atc ctg gcc tcc tat gct cgc atc ctt gtg gcc 672 Thr Pro Phe Val Cys Ile Leu Ala Ser Tyr Ala Arg Ile Leu Val Ala 210 215 220 atc atg aag gtc ccc tct gca ggc ggc agg aag aaa gcc ttc tcc acc 720 Ile Met Lys Val Pro Ser Ala Gly Gly Arg Lys Lys Ala Phe Ser Thr 225 230 235 240 tgc agc tcc cac ctg tct gtg gtt gct ctc ttc tat ggg acc acc att 768 Cys Ser Ser His Leu Ser Val Val Ala Leu Phe Tyr Gly Thr Thr Ile 245 250 255 ggc gtc tat ctg tgt ccc tcc tcg gtc ctc acc act gtg aag gag aaa 816 Gly Val Tyr Leu Cys Pro Ser Ser Val Leu Thr Thr Val Lys Glu Lys 260 265 270 gct tct gcg gtg atg tac aca gca gtc acc ccc atg ctg aat ccc ttc 864 Ala Ser Ala Val Met Tyr Thr Ala Val Thr Pro Met Leu Asn Pro Phe 275 280 285 atc tac agc ttg agg aac aga gac ctg aaa ggg gct ctc agg aag ctg 912 Ile Tyr Ser Leu Arg Asn Arg Asp Leu Lys Gly Ala Leu Arg Lys Leu 290 295 300 gtc aac aga aag atc acc tca tct tcc tga 942 Val Asn Arg Lys Ile Thr Ser Ser Ser 305 310 <210> 648 <211> 313 <212> PRT <213> Homo sapiens <400> 648 Met Glu Pro Arg Asn Gln Thr Ser Ala Ser Gln Phe Ile Leu Leu Gly 1 5 10 15 Leu Ser Glu Lys Pro Glu Gln Glu Thr Leu Leu Phe Ser Leu Phe Phe 20 25 30 Cys Met Tyr Leu Val Met Val Val Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Ile Ser Ile Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Leu Val Asp Phe Cys Leu Ala Thr Asn Thr Ile Pro Lys 65 70 75 80 Met Leu Val Ser Leu Gln Thr Gly Ser Lys Ala Ile Ser Tyr Pro Cys 85 90 95 Cys Leu Ile Gln Met Tyr Phe Phe His Phe Phe Gly Ile Val Asp Ser 100 105 110 Val Ile Ile Ala Met Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125 Pro Leu His Tyr Ala Lys Ile Met Ser Leu Arg Leu Cys Arg Leu Leu 130 135 140 Val Gly Ala Leu Trp Ala Phe Ser Cys Phe Ile Ser Leu Thr His Ile 145 150 155 160 Leu Leu Met Ala Arg Leu Val Phe Cys Gly Ser His Glu Val Pro His 165 170 175 Tyr Phe Cys Asp Leu Thr Pro Ile Leu Arg Leu Ser Cys Thr Asp Thr 180 185 190 Ser Val Asn Arg Ile Phe Ile Leu Ile Val Ala Gly Met Val Ile Ala 195 200 205 Thr Pro Phe Val Cys Ile Leu Ala Ser Tyr Ala Arg Ile Leu Val Ala 210 215 220 Ile Met Lys Val Pro Ser Ala Gly Gly Arg Lys Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Leu Ser Val Val Ala Leu Phe Tyr Gly Thr Thr Ile 245 250 255 Gly Val Tyr Leu Cys Pro Ser Ser Val Leu Thr Thr Val Lys Glu Lys 260 265 270 Ala Ser Ala Val Met Tyr Thr Ala Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Leu Lys Gly Ala Leu Arg Lys Leu 290 295 300 Val Asn Arg Lys Ile Thr Ser Ser Ser 305 310 <210> 649 <211> 954 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(954) <400> 649 atg aga aat ttg agt gga ggc cat gtc gag gag ttt gtc ttg gtg ggt 48 Met Arg Asn Leu Ser Gly Gly His Val Glu Glu Phe Val Leu Val Gly 1 5 10 15 ttc cct acc acg cct ccc ctc cag ctg ctc ctc ttt gtc ctt ttt ttt 96 Phe Pro Thr Thr Pro Pro Leu Gln Leu Leu Leu Phe Val Leu Phe Phe 20 25 30 gca att tac ctt ctg aca ttg ttg gag aat gca ctt att gtc ttc aca 144 Ala Ile Tyr Leu Leu Thr Leu Leu Glu Asn Ala Leu Ile Val Phe Thr 35 40 45 ata tgg ctt gct cca agc ctt cat cgt ccc atg tac ttt ttc ctt ggc 192 Ile Trp Leu Ala Pro Ser Leu His Arg Pro Met Tyr Phe Phe Leu Gly 50 55 60 cat ctc tct ttc ctg gag cta tgg tac atc aat gtc acc att cct cgg 240 His Leu Ser Phe Leu Glu Leu Trp Tyr Ile Asn Val Thr Ile Pro Arg 65 70 75 80 ctc ttg gca gcc ttt ctt acc cag gat ggt aga gtc tcc tac gta ggt 288 Leu Leu Ala Ala Phe Leu Thr Gln Asp Gly Arg Val Ser Tyr Val Gly 85 90 95 tgc atg acc caa ctg tac ttc ttt att gcc tta gcc tgt act gaa tgt 336 Cys Met Thr Gln Leu Tyr Phe Phe Ile Ala Leu Ala Cys Thr Glu Cys 100 105 110 gtg ctg ttg gca gtt atg gcc tat gat cgc tac ctg gcc atc tgt gga 384 Va l Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys Gly 115 120 125 ccc ctc ctt tac cct agt ctc atg cct tcc agt ctg gcc act cgc ctt 432 Pro Leu Leu Tyr Pro Ser Leu Met Pro Ser Ser Leu Ala Thr Arg Leu 130 135 140 gct gct gcc tct tgg ggc agt ggc ttc ttc agc tcc atg atg aag ctt 480 Ala Ala Ala Ser Trp Gly Ser Gly Phe Phe Ser Ser Met Met Lys Leu 145 150 155 160 ctt ttt att tcc caa ttg tcc tac tgt gga ccc aac att atc aac cac 528 Leu Phe Ile Ser Gln Leu Ser Tyr Cys Gly Pro Asn Ile Ile Asn His 165 170 175 ttt ttc tgt gat att tcc cca cta ctc aac ctc acc tgc tct gac aag 576 Phe Phe Cys Asp Ile Ser Pro Leu Leu Asn Leu Thr Cys Ser Asp Lys 180 185 190 gag caa gca gag cta gta gac ttc ctt ctg gcc ctg gtg atg att cta 624 Glu Gln Ala Glu Leu Val Asp Phe Leu Leu Ala Leu Val Met Ile Leu 195 200 205 ctc cct cta ttg gct gtg gtt tca tca tac act gcc atc att gca gcc 672 Leu Pro Leu Leu Ala Val Val Ser Ser Tyr Thr Ala Ile Ile Ala Ala 210 215 220 atc ctg agg atc cct acg tcc agg gga cgc cac aaa gcc ttt tcc act 720 Ile Leu Arg Ile Pro Thr Ser Arg Gly Arg His Lys Ala Phe Ser Thr 225 230 235 240 tgt gcc gct cat ctg gca gtg gtt gtt atc tac tac tcc tcc act ctc 768 Cys Ala Ala His Leu Ala Val Val Val Ile Tyr Tyr Ser Ser Thr Leu 245 250 255 ttc acc tat gca cgg ccc cgg gcc atg tac acc ttc aac cac aac aag 816 Phe Thr Tyr Ala Arg Pro Arg Ala Met Tyr Thr Phe Asn His Asn Lys 260 265 270 att atc tct gtg ctc tac act atc att gta cca ttc ttc aac cca gcc 864 Ile Ile Ser Val Leu Tyr Thr Ile Ile Val Pro Phe Phe Asn Pro Ala 275 280 285 atc tac tgc ctg agg aac aag gag gtg aag gag gcc ttc agg aag aca 912 Ile Tyr Cys Leu Arg Asn Lys Glu Val Lys Glu Ala Phe Arg Lys Thr 290 295 300 gtg atg ggc aga tgt cac tat cct agg gat gtt cag gac tga 954 Val Met Gly Arg Cys His Tyr Pro Arg Asp Val Gln Asp 305 310 315 <210> 650 <211> 317 <212> PRT <213> Homo sapiens <400> 650 Met Arg Asn Leu Ser Gly Gly His Val Glu Glu Phe Val Leu Val Gly 1 5 10 15 Phe Pro Thr Thr Pro Pro Leu Gln Leu Leu Leu Phe Val Leu Phe Phe 20 25 30 Ala Ile Tyr Leu Leu Thr Leu Leu Glu Asn Ala Leu Ile Val Phe Thr 35 40 45 Ile Trp Leu Ala Pro Ser Leu His Arg Pro Met Tyr Phe Phe Leu Gly 50 55 60 His Leu Ser Phe Leu Glu Leu Trp Tyr Ile Asn Val Thr Ile Pro Arg 65 70 75 80 Leu Leu Ala Ala Phe Leu Thr Gln Asp Gly Arg Val Ser Tyr Val Gly 85 90 95 Cys Met Thr Gln Leu Tyr Phe Phe Ile Ala Leu Ala Cys Thr Glu Cys 100 105 110 Val Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys Gly 115 120 125 Pro Leu Leu Tyr Pro Ser Leu Met Pro Ser Ser Leu Ala Thr Arg Leu 130 135 140 Ala Ala Ala Ser Trp Gly Ser Gly Phe Phe Ser Ser Met Met Lys Leu 145 150 155 160 Leu Phe Ile Ser Gln Leu Ser Tyr Cys Gly Pro Asn Ile Ile Asn His 165 170 175 Phe Phe Cys Asp Ile Ser Pro Leu Leu Asn Leu Thr Cys Ser Asp Lys 180 185 190 Glu Gln Ala Glu Leu Val Asp Phe Leu Leu Ala Leu Val Met Ile Leu 195 200 205 Leu Pro Leu Leu Ala Val Val Ser Ser Tyr Thr Ala Ile Ile Ala Ala 210 215 220 Ile Leu Arg Ile Pro Thr Ser Arg Gly Arg His Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ala His Leu Ala Val Val Val Ile Tyr Tyr Ser Ser Thr Leu 245 250 255 Phe Thr Tyr Ala Arg Pro Arg Ala Met Tyr Thr Phe Asn His Asn Lys 260 265 270 Ile Ile Ser Val Leu Tyr Thr Ile Ile Val Pro Phe Phe Asn Pro Ala 275 280 285 Ile Tyr Cys Leu Arg Asn Lys Glu Val Lys Glu Ala Phe Arg Lys Thr 290 295 300 Val Met Gly Arg Cys His Tyr Pro Arg Asp Val Gln Asp 305 310 315 <210> 651 <211> 759 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(759) <400> 651 atg tat ctc ttc ctt agt gca ctc tcc ttc tct gag acc tgc tat aca 48 Met Tyr Leu Phe Leu Ser Ala Leu Ser Phe Ser Glu Thr Cys Tyr Thr 1 5 10 15 ctg acc atc gtc ccc aag atg ctg gaa gat cta ctg gcc aag gac aga 96 Leu Thr Ile Val Pro Lys Met Leu Glu Asp Leu Leu Ala Lys Asp Arg 20 25 30 agc att tca gtc aca ggt tgt agc tta cag atg tgc ttc ttc ttg gga 144 Ser Ile Ser Val Thr Gly Cys Ser Leu Gln Met Cys Phe Phe Leu Gly 35 40 45 ctt ggt ggc aca aac tgt atc att ctc act ttg atg gga tat gac cgc 192 Leu Gly Gly Thr Asn Cys Ile Ile Leu Thr Leu Met Gly Tyr Asp Arg 50 55 60 ttc ctg gcc att tgt aac cct cta aga tat cca ctg ctt atg acc aac 240 Phe Leu Ala Ile Cys Asn Pro Leu Arg Tyr Pro Leu Leu Met Thr Asn 65 70 75 80 att gta tgt gga caa ctt gtg gcc tct gct tgc act gca ggc ttc ttt 288 Ile Val Cys Gly Gln Leu Val Ala Ser Ala Cys Thr Ala Gly Phe Phe 85 90 95 atc tct ctt aca gag act gca ctg ata ttc agg gac tct ttc tgc aga 336 Ile Ser Leu Thr Glu Thr Ala Leu Ile Phe Arg Asp Ser Phe Cys Arg 100 105 110 ccc aac ctt gtc aaa cac ttc ttc tgc cat atg ctg gca gtt att agg 384 Pro Asn Leu Val Lys His Phe Phe Cys His Met Leu Ala Val Ile Arg 115 120 125 ctg tct tgt ata gac agt aac cac aca gaa ttc att ata aca ctg atc 432 Leu Ser Cys Ile Asp Ser Asn His Thr Glu Phe Ile Ile Thr Leu Ile 130 135 140 tca gtg tct ggt ttg ctg ggt acc ctt ctg ctc atc atc ctg act gat 480 Ser Val Ser Gly Leu Leu Gly Thr Leu Leu Leu Ile Ile Leu Thr Asp 145 150 155 160 gtc ttc att att tct act gtc ctc agg atc cct tca gct gag ggc aag 528 Val Phe Ile Ile Ser Thr Val Leu Arg Ile Pro Ser Ala Glu Gly Lys 165 170 175 cag aag gcc ttc acc acc tgt gcc tcc cac ctc acc gtg gtt ata atc 576 Gln Lys Ala Phe Thr Thr Cys Ala Ser His Leu Thr Val Val Ile Ile 180 185 190 cac ttt ggt ttt gca tct att gtt tat ttg aag cca gaa gcc tca gga 624 His Phe Gly Phe Ala Ser Ile Val Tyr Leu Lys Pro Glu Ala Ser Gly 195 200 205 gat gac aca ctc ata gca gtc cct tat act gtc att acc ccc ttc ctc 672 Asp Asp Thr Leu Ile Ala Val Pro Tyr Thr Val Ile Thr Pro Phe Leu 210 215 220 agc ccc atc ata ttc agc ctg agg aat aag gac atg aaa aat gct ttt 720 Ser Pro Ile Ile Phe Ser Leu Arg Asn Lys Asp Met Lys Asn Ala Phe 225 230 235 240 aga aga atg atg gga aac aca gtt gcc ttg aaa aaa taa 759 Arg Arg Met Met Gly Asn Thr Val Ala Leu Lys Lys 245 250 <210> 652 <211> 252 <212> PRT <213> Homo sapiens <400> 652 Met Tyr Leu Phe Leu Ser Ala Leu Ser Phe Ser Glu Thr Cys Tyr Thr 1 5 10 15 Leu Thr Ile Val Pro Lys Met Leu Glu Asp Leu Leu Ala Lys Asp Arg 20 25 30 Ser Ile Ser Val Thr Gly Cys Ser Leu Gln Met Cys Phe Phe Leu Gly 35 40 45 Leu Gly Gly Thr Asn Cys Ile Ile Leu Thr Leu Met Gly Tyr Asp Arg 50 55 60 Phe Leu Ala Ile Cys Asn Pro Leu Arg Tyr Pro Leu Leu Met Thr Asn 65 70 75 80 Ile Val Cys Gly Gln Leu Val Ala Ser Ala Cys Thr Ala Gly Phe Phe 85 90 95 Ile Ser Leu Thr Glu Thr Ala Leu Ile Phe Arg Asp Ser Phe Cys Arg 100 105 110 Pro Asn Leu Val Lys His Phe Phe Cys His Met Leu Ala Val Ile Arg 115 120 125 Leu Ser Cys Ile Asp Ser Asn His Thr Glu Phe Ile Ile Thr Leu Ile 130 135 140 Ser Val Ser Gly Leu Leu Gly Thr Leu Leu Leu Ile Ile Leu Thr Asp 145 150 155 160 Val Phe Ile Ile Ser Thr Val Leu Arg Ile Pro Ser Ala Glu Gly Lys 165 170 175 Gln Lys Ala Phe Thr Thr Cys Ala Ser His Leu Thr Val Val Ile Ile 180 185 190 His Phe Gly Phe Ala Ser Ile Val Tyr Leu Lys Pro Glu Ala Ser Gly 195 200 205 Asp Asp Thr Leu Ile Ala Val Pro Tyr Thr Val Ile Thr Pro Phe Leu 210 215 220 Ser Pro Ile Ile Phe Ser Leu Arg Asn Lys Asp Met Lys Asn Ala Phe 225 230 235 240 Arg Arg Met Met Gly Asn Thr Val Ala Leu Lys Lys 245 250 <210> 653 <211> 942 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(942) <400> 653 atg ggg cag acc aac gta acc tcc tgg agg gat ttt gtc ttc ctg ggc 48 Met Gly Gln Thr Asn Val Thr Ser Trp Arg Asp Phe Val Phe Leu Gly 1 5 10 15 ttc tcc agt tct ggg gag ttg cag ctc ctt ctc ttt gcc ttg ttc ctc 96 Phe Ser Ser Ser Gly Glu Leu Gln Leu Leu Leu Phe Ala Leu Phe Leu 20 25 30 tct ctg tat cta gtc act ctg acc agc aat gtc ttc att atc ata gcc 144 Ser Leu Tyr Leu Val Thr Leu Thr Ser Asn Val Phe Ile Ile Ile Ala 35 40 45 atc agg ctg gat agc cat ctg cac acc ccc atg tac ctc ttc ctt tcc 192 Ile Arg Leu Asp Ser His Leu His Thr Pro Met Tyr Leu Phe Leu Ser 50 55 60 ttc cta tcc ttc tct gag acc tgc tac act ttg ggc atc atc cct aga 240 Phe Leu Ser Phe Ser Glu Thr Cys Tyr Thr Leu Gly Ile Ile Pro Arg 6 5 70 75 80 atg ctc tct ggc ctg gct ggg ggg gac cag gct atc tcc tat gtg ggc 288 Met Leu Ser Gly Leu Ala Gly Gly Asp Gln Ala Ile Ser Tyr Val Gly 85 90 95 tgt gct gcc cag atg ttc ttt tct gcc tca tgg gcc tgt act aac tgc 336 Cys Ala Ala Gln Met Phe Phe Ser Ala Ser Trp Ala Cys Thr Asn Cys 100 105 110 ttc ctt ctg gct gcc atg ggc ttt gac aga tat gtg gcc atc tgt gct 384 Phe Leu Leu Ala Ala Met Gly Phe Asp Arg Tyr Val Ala Ile Cys Ala 115 120 125 cca ctc cac tat gcc agc cac atg aat cct acc ctc tgt gcc cag ctg 432 Pro Leu His Tyr Ala Ser His Met Asn Pro Thr Leu Cys Ala Gln Leu 130 135 140 gtc att act tcc ttc ctg act gga tac ctc ttt gga ctg gga atg aca 480 Val Ile Thr Ser Phe Leu Thr Gly Tyr Leu Phe Gly Leu Gly Met Thr 145 150 155 160 cta gtt att ttc cac ctc tca ttc tgc agc tcc cat gaa atc cag cac 528 Leu Val Ile Phe His Leu Ser Phe Cys Ser Ser His Glu Ile Gln His 165 170 175 ttt ttt tgt gac acg cca cct gtg ctg agc cta gcc tgt gga gat aca 576 Phe Phe Cys Asp Thr Pro Pro Val Leu Ser Leu Ala Cys Gly Asp Thr 180 185 190 ggc ccg agt gag ctg agg atc ttt atc ctc agt ctt ttg gtc ctc ttg 624 Gly Pro Ser Glu Leu Arg Ile Phe Ile Leu Ser Leu Leu Val Leu Leu 195 200 205 gtc tcc ttc ttc ttc atc acc atc tcc tac gcc tac atc ttg gca gca 672 Val Ser Phe Phe Phe Ile Thr Ile Ser Tyr Ala Tyr Ile Leu Ala Ala 210 215 220 ata ctg agg atc ccc tct gct gag ggg cag aag aag gcc ttc tcc act 720 Ile Leu Arg Ile Pro Ser Ala Glu Gly Gln Lys Lys Ala Phe Ser Thr 225 230 235 240 tgt gcc tcg cac ctt aca gtg gtc att att cat tat ggc tgt gct tcc 768 Cys Ala Ser His Leu Thr Val Val Ile Ile His Tyr Gly Cys Ala Ser 245 250 255 ttc gtg tac ctg agg ccc aaa gcc agc tac tct ctt gag aga gat cag 816 Phe Val Tyr Leu Arg Pro Lys Ala Ser Tyr Ser Leu Glu Arg Asp Gln 260 265 270 ctt att gcc atg acc tat act gta gtg acc ccc ctc ctt aat ccc att 864 Leu Ile Ala Met Thr Tyr Thr Val Val Thr Pro Leu Leu Asn Pro Ile 275 280 285 gtt tat agt cta agg act agg gct ata cag aca gct ctg agg aat gct 912 Val Tyr Ser Leu Arg Thr Arg Ala Ile Gln Thr Ala Leu Arg Asn Ala 290 295 300 ttc aga ggg aga ttg ctg ggt aaa gga tga 942 Phe Arg Gly Arg Leu Leu Gly Lys Gly 305 310 <210> 654 <211> 313 <212> PRT <213> Homo sapiens <400> 654 Met Gly Gln Thr Asn Val Thr Ser Trp Arg Asp Phe Val Phe Leu Gly 1 5 10 15 Phe Ser Ser Ser Gly Glu Leu Gln Leu Leu Leu Phe Ala Leu Phe Leu 20 25 30 Ser Leu Tyr Leu Val Thr Leu Thr Ser Asn Val Phe Ile Ile Ile Ala 35 40 45 Ile Arg Leu Asp Ser His Leu His Thr Pro Met Tyr Leu Phe Leu Ser 50 55 60 Phe Leu Ser Phe Ser Glu Thr Cys Tyr Thr Leu Gly Ile Ile Pro Arg 65 70 75 80 Met Leu Ser Gly Leu Ala Gly Gly Asp Gln Ala Ile Ser Tyr Val Gly 85 90 95 Cys Ala Ala Gln Met Phe Phe Ser Ala Ser Trp Ala Cys Thr Asn Cys 100 105 110 Phe Leu Leu Ala Ala Met Gly Phe Asp Arg Tyr Val Ala Ile Cys Ala 115 120 125 Pro Leu His Tyr Ala Ser His Met Asn Pro Thr Leu Cys Ala Gln Leu 130 135 140 Val Ile Thr Ser Phe Leu Thr Gly Tyr Leu Phe Gly Leu Gly Met Thr 145 150 155 160 Leu Val Ile Phe His Leu Ser Phe Cys Ser Ser His Glu Ile Gln His 165 170 175 Phe Phe Cys Asp Thr Pro Pro Val Leu Ser Leu Ala Cys Gly Asp Thr 180 185 190 Gly Pro Ser Glu Leu Arg Ile Phe Ile Leu Ser Leu Leu Val Leu Leu 195 200 205 Val Ser Phe Phe Phe Ile Thr Ile Ser Tyr Ala Tyr Ile Leu Ala Ala 210 215 220 Ile Leu Arg Ile Pro Ser Ala Glu Gly Gln Lys Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Thr Val Val Ile Ile His Tyr Gly Cys Ala Ser 245 250 255 Phe Val Tyr Leu Arg Pro Lys Ala Ser Tyr Ser Leu Glu Arg Asp Gln 260 265 270 Leu Ile Ala Met Thr Tyr Thr Val Val Thr Pro Leu Leu Asn Pro Ile 275 280 285 Val Tyr Ser Leu Arg Thr Arg Ala Ile Gln Thr Ala Leu Arg Asn Ala 290 295 300 Phe Arg Gly Arg Leu Leu Gly Lys Gly 305 310 <210> 655 <211> 939 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(939) <400> 655 atg gac aca ggg aac tgg agc cag gta gca gaa ttc atc atc ttg ggc 48 Met Asp Thr Gly Asn Trp Ser Gln Val Ala Glu Phe Ile Ile Leu Gly 1 5 10 15 ttc ccc cat ctc cag ggt gtc cag att tat ctc ttc ctc ttg ttg ctt 96 Phe Pro His Leu Gln Gly Val Gln Ile Tyr Leu Phe Leu Leu Leu Leu 20 25 30 ctc att tac ctc atg act gtg ttg gga aac ctg ctg ata ttc ctg gtg 144 Leu Ile Tyr Leu Met Thr Val Leu Gly Asn Leu Leu Ile Phe Leu Val 35 40 45 gtc tgc ctg gac tcc cgg ctt cac aca ccc atg tac cac ttt gtc agc 192 Val Cys Leu Asp Ser Arg Leu His Thr Pro Met Tyr His Phe Val Ser 50 55 60 att ctc tcc ttc tca gag ctt ggc tat aca gct gcc acc atc cct aag 240 Ile Leu Ser Phe Ser Glu Leu Gly Tyr Thr Ala Ala Thr Ile Pro Lys 65 70 75 80 atg ctg gca aac ttg ttc agt gag aaa aag acc att tca ttc tct ggg 288 Met Leu Ala Asn Leu Phe Ser Glu Lys Lys Thr Ile Ser Phe Ser Gly 85 90 95 tgt ctc ctg cag atc tat ttc ttt cac tcc ctt gga gcg act gag tgc 336 Cys Leu Leu Gln Ile Tyr Phe Phe His Ser Leu Gly Ala Thr Glu Cys 100 105 110 tat ctc ctg aca gct atg gcc tac gat agg tat tta gcc atc tgc cgg 384 Tyr Leu Leu Thr Ala Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys Arg 115 120 125 ccc ctc cac tac cca acc ctc atg acc cca aca ctt tgt gca gag att 432 Pro Leu His Tyr Pro Thr Leu Met Thr Pro Thr Leu Cys Ala Glu Ile 130 135 140 gcc att ggc tgt tgg ttg gga ggc ttg gct ggg cca gta gtt gaa att 480 Ala Ile Gly Cys Trp Leu Gly Gly Leu Ala Gly Pro Val Val Glu Ile 145 150 155 160 tcc ttg att tca cgc ctc cca ttc tgt ggc ccc aat cgc att cag cac 528 Ser Leu Ile Ser Arg Leu Pro Phe Cys Gly Pro Asn Arg Ile Gln His 165 170 175 gtc ttt tgt gac ttc cct cct gtg ctg agt ttg gct tgc act gat acg 576 Val Phe Cys Asp Phe Pro Pro Val Leu Ser Leu Ala Cys Thr Asp Thr 180 185 190 tct aca aat gtc cta gta gat ttt gtt ata aat tcc tgc aag atc cta 624 Ser Thr Asn Val Leu Val Asp Phe Val Ile Asn Ser Cys Lys Ile Leu 195 200 205 gcc acc ttc ctg ctg atc ctc tgc tcc tat gtg cag atc atc tgc aca 672 Ala Thr Phe Leu Leu Ile Leu Cys Ser Tyr Val Gln Ile Ile Cys Thr 210 215 220 gtg ctc aga att ccc tca gct gcc ggc aag agg aag gcc atc tcc acg 720 Val Leu Arg Ile Pro Ser Ala Ala Gly Lys Arg Lys Ala Ile Ser Thr 225 230 235 240 tgt gcc tcc cac ctc act gtg gtt ctc atc ttc tat ggg agc atc ctt 768 Cys Ala Ser His Leu Thr Val Val Leu Ile Phe Tyr Gly Ser Ile Leu 245 250 255 tcc atg tat gtg cgg ctg aag aag agc tac tca ctg gac tat gac cag 816 Ser Met Tyr Val Arg Leu Lys Lys Ser Tyr Ser Leu Asp Tyr Asp Gln 260 265 270 gcc ctg gca gtg gtc tac tca gtg ctc aca ccc ttc ctc aac ccc ttc 864 Ala Leu Ala Val Val Tyr Ser Val Leu Thr Pro Phe Leu Asn Pro Phe 275 280 285 atc tac agc ttg cac aac aag gag atc aag gag gct gtg agg agg cag 912 Ile Tyr Ser Leu His Asn Lys Glu Ile Lys Glu Ala Val Arg Arg Gln 290 295 300 cta aag aga att ggg ata ttg gca tga 939 Leu Lys Arg Ile Gly Ile Leu Ala 305 310 <210> 656 <211> 312 <212> PRT <213> Homo sapiens <400> 656 Met Asp Thr Gly Asn Trp Ser Gln Val Ala Glu Phe Ile Ile Leu Gly 1 5 10 15 Phe Pro His Leu Gln Gly Val Gln Ile Tyr Leu Phe Leu Leu Leu Leu 20 25 30 Leu Ile Tyr Leu Met Thr Val Leu Gly Asn Leu Leu Ile Phe Leu Val 35 40 45 Val Cys Leu Asp Ser Arg Leu His Thr Pro Met Tyr His Phe Val Ser 50 55 60 Ile Leu Ser Phe Ser Glu Leu Gly Tyr Thr Ala Ala Thr Ile Pro Lys 65 70 75 80 Met Leu Ala Asn Leu Phe Ser Glu Lys Lys Thr Ile Ser Phe Ser Gly 85 90 95 Cys Leu Leu Gln Ile Tyr Phe Phe His Ser Leu Gly Ala Thr Glu Cys 100 105 110 Tyr Leu Leu Thr Ala Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys Arg 115 120 125 Pro Leu His Tyr Pro Thr Leu Met Thr Pro Thr Leu Cys Ala Glu Ile 130 135 140 Ala Ile Gly Cys Trp Leu Gly Gly Leu Ala Gly Pro Val Val Glu Ile 145 150 155 160 Ser Leu Ile Ser Arg Leu Pro Phe Cys Gly Pro Asn Arg Ile Gln His 165 170 175 Val Phe Cys Asp Phe Pro Pro Val Leu Ser Leu Ala Cys Thr Asp Thr 180 185 190 Ser Thr Asn Val Leu Val Asp Phe Val Ile Asn Ser Cys Lys Ile Leu 195 200 205 Ala Thr Phe Leu Leu Ile Leu Cys Ser Tyr Val Gln Ile Ile Cys Thr 210 215 220 Val Leu Arg Ile Pro Ser Ala Ala Gly Lys Arg Lys Ala Ile Ser Thr 225 230 235 240 Cys Ala Ser His Leu Thr Val Val Leu Ile Phe Tyr Gly Ser Ile Leu 245 250 255 Ser Met Tyr Val Arg Leu Lys Lys Ser Tyr Ser Leu Asp Tyr Asp Gln 260 265 270 Ala Leu Ala Val Val Tyr Ser Val Leu Thr Pro Phe Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu His Asn Lys Glu Ile Lys Glu Ala Val Arg Arg Gln 290 295 300 Leu Lys Arg Ile Gly Ile Leu Ala 305 310 <210> 657 <211> 1047 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1047) <400> 657 atg ctc act tca tta act gat ctc tgt ttc tct cct att cag gta gct 48 Met Leu Thr Ser Leu Thr Asp Leu Cys Phe Ser Pro Ile Gln Val Ala 1 5 10 15 gaa att aag tcc ctt cca aaa tcg atg aat gag aca aat cat tct cgg 96 Glu Ile Lys Ser Leu Pro Lys Ser Met Asn Glu Thr Asn His Ser Arg 20 25 30 gtg aca gaa ttt gtg ttg ctg gga ctg tct agt tca agg gag ctc caa 144 Val Thr Glu Phe Val Leu Leu Gly Leu Ser Ser Ser Arg Glu Leu Gln 35 40 45 cct ttc ttg ttt ctt aca ttt tca cta ctt tat cta gca att ctg ttg 192 Pro Phe Leu Phe Leu Thr Phe Ser Leu Leu Tyr Leu Ala Ile Leu Leu 50 55 60 ggc aac ttt ctc atc atc ctc act gtg acc tca gat tcc cgc ctt cac 240 Gly Asn Phe Leu Ile Ile Leu Thr Val Thr Ser Asp Ser Arg Leu His 65 70 75 80 acc ccc atg tac ttt ctg ctt gca aac ctg tca ttt ata gac gta tgt 288 Thr Pro Met Tyr Phe Leu Leu Ala Asn Leu Ser Phe Ile Asp Val Cys 85 90 95 gtt gcc tct ttt gct acc cct aaa atg att gca gac ttt ctg gtt gag 336 Val Ala Ser Phe Ala Thr Pro Lys Met Ile Ala Asp Phe Leu Val Glu 100 105 110 cgc aag act att tct ttt gat gcc tgc ctg gcc cag att ttc ttt gtt 384 Arg Lys Thr Ile Ser Phe Asp Ala Cys Leu Ala Gln Ile Phe Phe Val 115 120 125 cat ctc ttc act ggc agt gaa atg gtg ctc cta gtt tcc atg gcc tat 432 Hi s Leu Phe Thr Gly Ser Glu Met Val Leu Leu Val Ser Met Ala Tyr 130 135 140 gac cgt tat gtt gct ata tgc aaa cct ctc cac tac atg aca gtc atg 480 Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu His Tyr Met Thr Val Met 145 150 155 160 agc cgt cgt gta tgt gtt gtg ctc gtc ctc att tca tgg ttt gtg ggc 528 Ser Arg Arg Val Cys Val Val Leu Val Leu Ile Ser Trp Phe Val Gly 165 170 175 ttc atc cat act acc agc cag ttg gca ttc act gtt aat ctg cca ttt 576 Phe Ile His Thr Thr Ser Gln Leu Ala Phe Thr Val Asn Leu Pro Phe 180 185 190 tgt ggt cct aat aag gta gac agt ttt ttc tgt gac ctt cct cta gtg 624 Cys Gly Pro Asn Lys Val Asp Ser Phe Phe Cys Asp Leu Pro Leu Val 195 200 205 acc aag tta gcc tgc ata gac act tat gtt gtc agc tta cta ata gtt 672 Thr Lys Leu Ala Cys Ile Asp Thr Tyr Val Val Ser Leu Leu Ile Val 210 215 220 gca gat agt ggc ttt ctt tct ctg agt tcc ttt ctc ctc ttg gtt gtc 720 Ala Asp Ser Gly Phe Leu Ser Leu Ser Ser Phe Leu Leu Leu Val Val 225 230 235 240 tcc tac act gta ata ctt gtt aca gtt agg aat cgc tcc tct gca agc 768 Ser Tyr Thr Val Ile Leu Val Thr Val Arg Asn Arg Ser Ser Ala Ser 245 250 255 atg gcg aag gcc cgc tcc aca ttg act gct cac atc act gtg gtc act 816 Met Ala Lys Ala Arg Ser Thr Leu Thr Ala His Ile Thr Val Val Thr 260 265 270 tta ttc ttt gga cca tgc att ttc atc tat gtg tgg ccc ttc agc agt 864 Leu Phe Phe Gly Pro Cys Ile Phe Ile Tyr Val Trp Pro Phe Ser Ser 275 280 285 tac tca gtt gac aaa gtc ctt gct gta ttc tac acc atc ttc acg ctt 912 Tyr Ser Val Asp Lys Val Leu Ala Val Phe Tyr Thr Ile Phe Thr Leu 290 295 300 att tta aac cct gta atc tac acg cta aga aac aaa gaa gtg aag gca 960 Ile Leu Asn Pro Val Ile Tyr Thr Leu Arg Asn Lys Glu Val Lys Ala 305 310 315 320 gct atg tca aaa ctg aag agt cgg tat ctg aag cct agt cag gtt tct 1008 Ala Met Ser Lys Leu Lys Ser Arg Tyr Leu Lys Pro Ser Gln Val Ser 325 330 335 gta gtc ata aga aat gtt ctt ttc cta gaa aca aag taa 1047 Val Val Ile Arg Asn Val Leu Phe Leu Glu Thr Lys 340 345 <210> 658 <211> 348 <212> PRT <213> Homo sapiens <400> 658 Met Leu Thr Ser Leu Thr Asp Leu Cys Phe Ser Pro Ile Gln Val Ala 1 5 10 15 Glu Ile Lys Ser Leu Pro Lys Ser Met Asn Glu Thr Asn His Ser Arg 20 25 30 Val Thr Glu Phe Val Leu Leu Gly Leu Ser Ser Ser Arg Glu Leu Gln 35 40 45 Pro Phe Leu Phe Leu Thr Phe Ser Leu Leu Tyr Leu Ala Ile Leu Leu 50 55 60 Gl y Asn Phe Leu Ile Ile Leu Thr Val Thr Ser Asp Ser Arg Leu His 65 70 75 80 Thr Pro Met Tyr Phe Leu Leu Ala Asn Leu Ser Phe Ile Asp Val Cys 85 90 95 Val Ala Ser Phe Ala Thr Pro Lys Met Ile Ala Asp Phe Leu Val Glu 100 105 110 Arg Lys Thr Ile Ser Phe Asp Ala Cys Leu Ala Gln Ile Phe Phe Val 115 120 125 His Leu Phe Thr Gly Ser Glu Met Val Leu Leu Val Ser Met Ala Tyr 130 135 140 Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu His Tyr Met Thr Val Met 145 150 155 160 Ser Arg Arg Val Cys Val Val Leu Val Leu Ile Ser Trp Phe Val Gly 165 170 175 Phe Ile His Thr Thr Ser Gln Leu Ala Phe Thr Val Asn Leu Pro Phe 180 185 190 Cys Gly Pro Asn Lys Val Asp Ser Phe Phe Cys Asp Leu Pro Leu Val 195 200 205 Thr Lys Leu Ala Cys Ile Asp Thr Tyr Val Val Ser Leu Leu Ile Val 210 215 220 Ala Asp Ser Gly Phe Leu Ser Leu Ser Ser Phe Leu Leu Leu Val Val 225 230 235 240 Ser Tyr Thr Val Ile Leu Val Thr Val Arg Asn Arg Ser Ser Ala Ser 245 250 255 Met Ala Lys Ala Arg Ser Thr Leu Thr Ala His Ile Thr Val Val Thr 260 265 270 Leu Phe Phe Gly Pro Cys Ile Phe Ile Tyr Val Trp Pro Phe Ser Ser 275 280 285 Tyr Ser Val Asp Lys Val Leu Ala Val Phe Tyr Thr Ile Phe Thr Leu 290 295 300 Ile Leu Asn Pro Val Ile Tyr Thr Leu Arg Asn Lys Glu Val Lys Ala 305 310 315 320 Ala Met Ser Lys Leu Lys Ser Arg Tyr Leu Lys Pro Ser Gln Val Ser 325 330 335 Val Val Ile Arg Asn Val Leu Phe Leu Glu Thr Lys 340 345 <210> 659 <211> 1032 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1032) <400> 659 atg cat ttt ctt cct act gtc ttt ggc ttc cta aac aga gtc aca ctt 48 Met His Phe Leu Pro Thr Val Phe Gly Phe Leu Asn Arg Val Thr Leu 1 5 10 15 ggt atc ttc aga gag act atg gtc aat ttg act tca atg agt gga ttc 96 Gly Ile Phe Arg Glu Thr Met Val Asn Leu Thr Ser Met Ser Gly Phe 20 25 30 ctt ctt atg ggg ttt tct gat gag cgt aag ctt cag att tta cat gca 144 Leu Leu Met Gly Phe Ser Asp Glu Arg Lys Leu Gln Ile Leu His Ala 35 40 45 ttg gta ttt ctg gtg aca tac ctg ctg gcc ttg aca ggc aac ctc ctc 192 Leu Val Phe Leu Val Thr Tyr Leu Leu Ala Leu Thr Gly Asn Leu Leu 50 55 60 att atc acc atc att acc gtg gac cgt cgt ctc cat tcc ccc atg tat 240 Ile Ile Thr Ile Ile Thr Val Asp Arg Arg Leu His Ser Pro Met Tyr 65 70 75 80 tac ttt tta aag cac ctc tct ctt ctg gac ctc tgc ttc atc tct gtc 288 Tyr Phe Leu Lys His Leu Ser Leu Leu Asp Leu Cys Phe Ile Ser Val 85 90 95 aca gtc ccc cag tcc att gca aat tca ctt atg ggc aac ggt tac att 336 Thr Val Pro Gln Ser Ile Ala Asn Ser Leu Met Gly Asn Gly Tyr Ile 100 105 110 tct ctt gtt cag tgc att ctt cag gtt ttc ttc ttc ata gct ctg gcc 384 Ser Leu Val Gln Cys Ile Leu Gln Val Phe Phe Phe Ile Ala Leu Ala 115 120 125 tca tca gaa gtg gcc att ctc aca gtg atg tct tat gac agg tac gca 432 Ser Ser Glu Val Ala Ile Leu Thr Val Met Ser Tyr Asp Arg Tyr Ala 130 135 140 gca atc tgt caa cca ctt cat tat gag act att atg gat ccc cgt gcc 480 Ala Ile Cys Gln Pro Leu His Tyr Glu Thr Ile Met Asp Pro Arg Ala 145 150 155 160 tgt agg cat gca gtg ata gct gtg tgg att gct ggg ggc ctc tct ggg 528 Cys Arg His Ala Val Ile Ala Val Trp Ile Ala Gly Gly Leu Ser Gly 165 170 175 ctc atg cat gct gcc att aac ttc tcc ata cct ctc tgt ggg aag aga 576 Leu Met His Ala Ala Ile Asn Phe Ser Ile Pro Leu Cys Gly Lys Arg 180 185 190 gtc att cac caa ttc ttc tgt gat gtt cct cag atg ctg aaa cta gcc 624 Val Ile His Gln Phe Phe Cys Asp Val Pro Gln Met Leu Lys Leu Ala 195 200 205 tgt tct tat gaa ttc att aat gag att gca ctg gct gca ttc aca acg 672 Cys Ser Tyr Glu Phe Ile Asn Glu Ile Ala Leu Ala Ala Phe Thr Thr 210 215 220 tct gca gca ttt atc tgt ttg atc tcc att gtg ctc tcc tac att cgc 720 S er Ala Ala Phe Ile Cys Leu Ile Ser Ile Val Leu Ser Tyr Ile Arg 225 230 235 240 atc ttc tct aca gtg ctg aga atc cca tca gct gag ggc cgg acc aag 768 Ile Phe Ser Thr Val Leu Arg Ile Pro Ser Ala Glu Gly Arg Thr Lys 245 250 255 gtc ttc tcc acc tgc cta cca cac cta ttt gta gcc acc ttc ttt ctt 816 Val Phe Ser Thr Cys Leu Pro His Leu Phe Val Ala Thr Phe Phe Leu 260 265 270 tca gct gca ggc ttt gag ttt ctc aga ctg cct tct gat tcc tca tcg 864 Ser Ala Ala Gly Phe Glu Phe Leu Arg Leu Pro Ser Asp Ser Ser Ser 275 280 285 act gtg gac ctt gta ttc tcc gta ttc tat act gtg ata cct cca aca 912 Thr Val Asp Leu Val Phe Ser Val Phe Tyr Thr Val Ile Pro Pro Thr 290 295 300 ctc aat cca gtc att tat agc tta cgg aat gat tcc atg aag gca gca 960 Leu Asn Pro Val Ile Tyr Ser Leu Arg Asn Asp Ser Met Lys Ala Ala 305 310 315 320 ctg agg aag atg ctg tca aag gaa gag ctt cct cag aga aaa atg tgc 1008 Leu Arg Lys Met Leu Ser Lys Glu Glu Leu Pro Gln Arg Lys Met Cys 325 330 335 tta aaa gcc atg ttt aaa ctc tga 1032 Leu Lys Ala Met Phe Lys Leu 340 <210> 660 <211> 343 <212> PRT <213> Homo sapiens <400> 660 Met His Phe Leu Pro Thr Val Phe Gly Phe Leu Asn Arg Val Thr Leu 1 5 10 15 Gly Ile Phe Arg Glu Thr Met Val Asn Leu Thr Ser Met Ser Gly Phe 20 25 30 Leu Leu Met Gly Phe Ser Asp Glu Arg Lys Leu Gln Ile Leu His Ala 35 40 45 Leu Val Phe Leu Val Thr Tyr Leu Leu Ala Leu Thr Gly Asn Leu Leu 50 55 60 Ile Ile Thr Ile Ile Thr Val Asp Arg Arg Leu His Ser Pro Met Tyr 65 70 75 80 Tyr Phe Leu Lys His Leu Ser Leu Leu Asp Leu Cys Phe Ile Ser Val 85 90 95 Thr Val Pro Gln Ser Ile Ala Asn Ser Leu Met Gly Asn Gly Tyr Ile 100 105 110 Ser Leu Val Gln Cys Ile Leu Gln Val Phe Phe Phe Ile Ala Leu Ala 115 120 125 Ser Ser Glu Val Ala Ile Leu Thr Val Met Ser Tyr Asp Arg Tyr Ala 130 135 140 Ala Ile Cys Gln Pro Leu His Tyr Glu Thr Ile Met Asp Pro Arg Ala 145 150 155 160 Cys Arg His Ala Val Ile Ala Val Trp Ile Ala Gly Gly Leu Ser Gly 165 170 175 Leu Met His Ala Ala Ile Asn Phe Ser Ile Pro Leu Cys Gly Lys Arg 180 185 190 Val Ile His Gln Phe Phe Cys Asp Val Pro Gln Met Leu Lys Leu Ala 195 200 205 Cys Ser Tyr Glu Phe Ile Asn Glu Ile Ala Leu Ala Ala Phe Thr Thr 210 215 220 Ser Ala Ala Phe Ile Cys Leu Ile Ser Ile Val Leu Ser Tyr Ile Arg 225 230 235 240 Ile Phe Ser Thr Val Leu Arg Ile Pro Ser Ala Glu Gly Arg Thr Lys 245 250 255 Val Phe Ser Thr Cys Leu Pro His Leu Phe Val Ala Thr Phe Phe Leu 260 265 270 Ser Ala Ala Gly Phe Glu Phe Leu Arg Leu Pro Ser Asp Ser Ser Ser 275 280 285 Thr Val Asp Leu Val Phe Ser Val Phe Tyr Thr Val Ile Pro Pro Thr 290 295 300 Leu Asn Pro Val Ile Tyr Ser Leu Arg Asn Asp Ser Met Lys Ala Ala 305 310 315 320 Leu Arg Lys Met Leu Ser Lys Glu Glu Leu Pro Gln Arg Lys Met Cys 325 330 335 Leu Lys Ala Met Phe Lys Leu 340 <210> 661 <211> 951 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(951) <400> 661 atg gag aat gtc act aca atg aat gag ttt ctt cta ctt ggc ctg act 48 Met Glu Asn Val Thr Thr Met Asn Glu Phe Leu Leu Leu Gly Leu Thr 1 5 10 15 ggt gtt cag gag ctg cag cct ttc ttc ttt ggg att ttc tta atc att 96 Gly Val Gln Glu Leu Gln Pro Phe Phe Phe Gly Ile Phe Leu Ile Ile 20 25 30 tac ctg ata aac ttg att gga aat gga tct ata ttg gtg atg gtt gtt 144 Tyr Leu Ile Asn Leu Ile Gly Asn Gly Ser Ile Leu Val Met Val Val 35 40 45 ttg gaa cca caa ctc cac tcc cct atg tat ttt ttt ctg gga aac ctt 192 Leu Glu Pro Gln Leu His Ser Pro Met Tyr Phe Phe Leu Gly Asn Leu 50 55 60 tct tgt ctg gat att tct tat tct tca gtg aca ctg ccc aag ctg ctc 240 Ser Cys Leu Asp Ile Ser Tyr Ser Ser Val Thr Leu Pro Lys Leu Leu 65 70 75 80 gta aac ctc gtg tgc agt cgc agg gct ata tct ttt cta ggc tgt atc 288 Val Asn Leu Val Cys Ser Arg Arg Ala Ile Ser Phe Leu Gly Cys Ile 85 90 95 acc cag cta cac ttc ttc cac ttt ttg gga agc aca gag gcc att tta 336 Thr Gln Leu His Phe Phe His Phe Leu Gly Ser Thr Glu Ala Ile Leu 100 105 110 ctg gct atc atg gcc ttt gac cgt ttt gtt gcc atc tgc aat cct ctt 384 Leu Ala Ile Met Ala Phe Asp Arg Phe Val Ala Ile Cys Asn Pro Leu 115 120 125 cgc tac act gtc atc atg aac ccc cag gtg tgt att ctg ttg gca gct 432 Arg Tyr Thr Val Ile Met Asn Pro Gln Val Cys Ile Leu Leu Ala Ala 130 135 140 gcg gcc tgg ctc atc agc ttc ttt tac gct ctg atg cat tct gtc atg 480 Ala Ala Trp Leu Ile Ser Phe Phe Tyr Ala Leu Met His Ser Val Met 145 150 155 160 act gca cac ctg agt ttt tgt ggc tct cag aaa ctc aat cac ttc ttc 528 Thr Ala His Leu Ser Phe Cys Gly Ser Gln Lys Leu Asn His Phe Phe 165 170 175 tac gat gtc aag ccg ctc tta gaa ttg gcc tgt agt gac aca tta ctc 576 Tyr Asp Val Lys Pro Leu Leu Glu Leu Ala Cys Ser Asp Thr Leu Leu 180 185 190 aat caa tgg ctt ctt tcc att gtc aca ggc agc ata tcc atg gga gct 624 Asn Gln Trp Leu Leu Ser Ile Val Thr Gly Ser Ile Ser Met Gly Ala 195 200 205 ttc ttt ctg act ctt ctc tcc tgc ttc tat gta att ggc ttc ctt ctg 672 Phe Phe Leu Thr Leu Leu Ser Cys Phe Tyr Val Ile Gly Phe Leu Leu 210 215 220 ttt aag aac agg tcc tgc aga ata ctc cac aag gct ctg tcc act tgt 720 Phe Lys Asn Arg Ser Cys Arg Ile Leu His Lys Ala Leu Ser Thr Cys 225 230 235 240 gcc tcc cat ttt atg gtg gta tgt ctt ttc tat gga cct gtg ggc ttc 768 Ala Ser His Phe Met Val Val Cys Leu Phe Tyr Gly Pro Val Gly Phe 245 250 255 aca tat att cgt cct gct tca gcc acc tcc atg att cag gac cgg ata 816 Thr Tyr Ile Arg Pro Ala Ser Ala Thr Ser Met Ile Gln Asp Arg Ile 260 265 270 atg gcc atc atg tat agc gcc gtc acc cct gta ctg aat cca cta atc 864 Met Ala Ile Met Tyr Ser Ala Val Thr Pro Val Leu Asn Pro Leu Ile 275 280 285 tac acc ctt agg aac aaa gaa gtg atg atg gct ctg aag aaa atc ttt 912 Tyr Thr Leu Arg Asn Lys Glu Val Met Met Ala Leu Lys Lys Ile Phe 290 295 300 ggt agg aag ttg ttt aaa gac tgg cag caa cac cac tag 951 Gly Arg Lys Leu Phe Lys Asp Trp Gln Gln His His 305 310 315 <210> 662 <211> 316 <212> PRT <213> Homo sapiens <400> 662 Met Glu Asn Val Thr Thr Met Asn Glu Phe Leu Leu Leu Gly Leu Thr 1 5 10 15 Gly Val Gln Glu Leu Gln Pro Phe Phe Phe Gly Ile Phe Leu Ile Ile 20 25 30 Tyr Leu Ile Asn Leu Ile Gly Asn Gly Ser Ile Leu Val Met Val Val 35 40 45 Leu Glu Pro Gln Leu His Ser Pro Met Tyr Phe Phe Leu Gly Asn Leu 50 55 60 Ser Cys Leu Asp Ile Ser Tyr Ser Ser Val Thr Leu Pro Lys Leu Leu 65 70 75 80 Val Asn Leu Val Cys Ser Arg Arg Ala Ile Ser Phe Leu Gly Cys Ile 85 90 95 Thr Gln Leu His Phe Phe His Phe Leu Gly Ser Thr Glu Ala Ile Leu 100 105 110 Leu Ala Ile Met Ala Phe Asp Arg Phe Val Ala Ile Cys Asn Pro Leu 115 120 125 Arg Tyr Thr Val Ile Met Asn Pro Gln Val Cys Ile Leu Leu Ala Ala 130 135 140 Ala Ala Trp Leu Ile Ser Phe Phe Tyr Ala Leu Met His Ser Val Met 145 150 155 160 Thr Ala His Leu Ser Phe Cys Gly Ser Gln Lys Leu Asn His Phe Phe 165 170 175 Tyr Asp Val Lys Pro Leu Leu Glu Leu Ala Cys Ser Asp Thr Leu Leu 180 185 190 Asn Gln Trp Leu Leu Ser Ile Val Thr Gly Ser Ile Ser Met Gly Ala 195 200 205 Phe Phe Leu Thr Leu Leu Ser Cys Phe Tyr Val Ile Gly Phe Leu Leu 210 215 220 Phe Lys Asn Arg Ser Cys Arg Ile Leu His Lys Ala Leu Ser Thr Cys 225 230 235 240 Ala Ser His Phe Met Val Val Cys Leu Phe Tyr Gly Pro Val Gly Phe 245 250 255 Thr Tyr Ile Arg Pro Ala Ser Ala Thr Ser Met Ile Gln Asp Arg Ile 260 265 270 Met Ala Ile Met Tyr Ser Ala Val Thr Pro Val Leu Asn Pro Leu Ile 275 280 285 Tyr Thr Leu Arg Asn Lys Glu Val Met Met Ala Leu Lys Lys Ile Phe 290 295 300 Gly Arg Lys Leu Phe Lys Asp Trp Gln Gln His His 305 310 315 <210> 663 <211> 966 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(966) <400> 663 atg gaa aga aag aat caa aca gct ata act gaa ttc atc atc ttg gga 48 Met Glu Arg Lys Asn Gln Thr Ala Ile Thr Glu Phe Ile Ile Leu Gly 1 5 10 15 ttc tcc aac cta aat gaa ttg cag ttt tta cta ttc acc atc ttc ttt 96 Phe Ser Asn Leu Asn Glu Leu Gln Phe Leu Leu Phe Thr Ile Phe Phe 20 25 30 ctg act tat ttc tgt act ttg gga gga aat ata tta att atc ttg acg 144 Leu Thr Tyr Phe Cys Thr Leu Gly Gly Asn Ile Leu Ile Ile Leu Thr 35 40 45 act gtg act gat cca cac ctg cat aca cct atg tat tat ttt cta ggg 192 Thr Val Thr Asp Pro His Leu His Thr Pro Met Tyr Tyr Phe Leu Gly 50 55 60 aac ttg gcc ttt att gac atc tgc tac acc acc agc aat gtc ccc cag 240 Asn Leu Ala Phe Ile Asp Ile Cys Tyr Thr Thr Ser Asn Val Pro Gln 65 70 75 80 atg atg gtg cac ctc ctc tca aag aaa aaa agc att tct tat gtg ggg 288 Met Met Val His Leu Leu Ser Lys Lys Lys Ser Ile Ser Tyr Val Gly 85 90 95 tgt gtg gtt caa ctt ttt gca ttt gtt ttc ttt gta gga tca gag tgt 336 Cys Val Val Gln Leu Phe Ala Phe Val Phe Phe Val Gly Ser Glu Cys 100 105 110 ctc cta ctg gca gca atg gca tat gat cgt tac att gca atc tgc aat 384 Leu Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Ile Ala Ile Cys Asn 115 120 125 cct tta agg tat tca gtt att ctg agc aag gtt cta tgc aat caa tta 432 Pro Leu Arg Tyr Ser Val Ile Leu Ser Lys Val Leu Cys Asn Gln Leu 130 135 140 gca gcc tca tgc tgg gct gct ggt ttc ctt aac tca gtg gtg cat aca 480 Ala Ala Ser Cys Trp Ala Ala Gly Phe Leu Asn Ser Val Val His Thr 145 150 155 160 gtg ttg aca ttc tgc ctg ccc ttc tgt ggc aac aat cag att aat tac 528 Val Leu Thr Phe Cys Leu Pro Phe Cys Gly Asn Asn Gln Ile Asn Tyr 165 170 175 ttc ttc tgt gac atc ccc cct ttg ctg atc ttg tct tgt gga aac act 576 Phe Phe Cys Asp Ile Pro Pro Leu Leu Ile Leu Ser Cys Gly Asn Thr 180 185 190 tct gtc aat gag ttg gca ctg cta tcc act ggg gtc ttc att ggt tgg 624 Ser Val Asn Glu Leu Ala Leu Leu Ser Thr Gly Val Phe Ile Gly Trp 195 200 205 act cct ttc ctt tgt atc gta ctt tcc tac att tgc ata atc tcc acc 672 Thr Pro Phe Leu Cys Ile Val Leu Ser Tyr Ile Cys Ile Ile Ser Thr 210 215 220 atc ttg agg atc cag tcc tca gag gga aga cga aaa gcc ttt tct aca 720 Ile Leu Arg Ile Gln Ser Ser Glu Gly Arg Arg Lys Ala Phe Ser Thr 225 230 235 240 tgt gcc tcc cac ctg gcc att gtc ttt ctc ttt tat ggc agc gcc atc 768 Cys Ala Ser His Leu Ala Ile Val Phe Leu Phe Tyr Gly Ser Ala Ile 245 250 255 ttt aca tat gta cgg ccc atc tca act tac tca tta aag aaa gat agg 816 Phe Thr Tyr Val Arg Pro Ile Ser Thr Tyr Ser Leu Lys Lys Asp Arg 260 265 270 ttg gtt tca gtg ttg tac agt gtt gtt acc ccc atg cta aac cct ata 864 Leu Val Ser Val Leu Tyr Ser Val Val Thr Pro Met Leu Asn Pro Ile 275 280 285 att tac aca ttg agg aat aag gac atc aaa gaa gct gtc aaa act ata 912 Ile Tyr Thr Leu Arg Asn Lys Asp Ile Lys Glu Ala Val Lys Thr Ile 290 295 300 ggg agc aag tgg cag cca cca att tcc tct ttg gat agt aaa ctc act 960 Gly Ser Lys Trp Gln Pro Pro Ile Ser Ser Leu Asp Ser Lys Leu Thr 305 310 315 320 tat tga 966 Tyr <210> 664 <211> 321 <212> PRT <213> Homo sapiens <400> 664 Met Glu Arg Lys Asn Gln Thr Ala Ile Thr Glu Phe Ile Ile Leu Gly 1 5 10 15 Phe Ser Asn Leu Asn Glu Leu Gln Phe Leu Leu Phe Thr Ile Phe Phe 20 25 30 Leu Thr Tyr Phe Cys Thr Leu Gly Gly Asn Ile Leu Ile Ile Leu Thr 35 40 45 Thr Val Thr Asp Pro His Leu His Thr Pro Met Tyr Tyr Phe Leu Gly 50 55 60 Asn Leu Ala Phe Ile Asp Ile Cys Tyr Thr Thr Ser Asn Val Pro Gln 65 70 75 80 Met Met Val His Leu Leu Ser Lys Lys Lys Ser Ile Ser Tyr Val Gly 85 90 95 Cys Val Val Gln Leu Phe Ala Phe Val Phe Phe Val Gly Ser Glu Cys 100 105 110 Leu Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Ile Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Ser Val Ile Leu Ser Lys Val Leu Cys Asn Gln Leu 130 135 140 Ala Ala Ser Cys Trp Ala Ala Gly Phe Leu Asn Ser Val Val His Thr 145 150 155 160 Val Leu Thr Phe Cys Leu Pro Phe Cys Gly Asn Asn Gln Ile Asn Tyr 165 170 175 Phe Phe Cys Asp Ile Pro Pro Leu Leu Ile Leu Ser Cys Gly Asn Thr 180 185 190 Ser Val Asn Glu Leu Ala Leu Leu Ser Thr Gly Val Phe Ile Gly Trp 195 200 205 Thr Pro Phe Leu Cys Ile Val Leu Ser Tyr Ile Cys Ile Ile Ser Thr 210 215 220 Ile Leu Arg Ile Gln Ser Ser Glu Gly Arg Arg Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Ala Ile Val Phe Leu Phe Tyr Gly Ser Ala Ile 245 250 255 Phe Thr Tyr Val Arg Pro Ile Ser Thr Tyr Ser Leu Lys Lys Asp Arg 260 265 270 Leu Val Ser Val Leu Tyr Ser Val Val Thr Pro Met Leu Asn Pro Ile 275 280 285 Ile Tyr Thr Leu Arg Asn Lys Asp Ile Lys Glu Ala Val Lys Thr Ile 290 295 300 Gly Ser Lys Trp Gln Pro Pro Ile Ser Ser Leu Asp Ser Lys Leu Thr 305 310 315 320 Tyr <210> 665 <211> 1002 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1002) <400> 665 atg ttg act cta act cgc atc cgc act gtg tcc tat gaa gtc agg agt 48 Met Leu Thr Leu Thr Arg Ile Arg Thr Val Ser Tyr Glu Val Arg Ser 1 5 10 15 aca ttt ctg ttc att tca gtc ctg gag ttt gca gtg ggg ttt ctg acc 96 Thr Phe Leu Phe Ile Ser Val Leu Glu Phe Ala Val Gly Phe Leu Thr 20 25 30 aat gcc ttc gtt ttc ttg gtg aat ttt tgg gat gta gtg aag agg cag 144 Asn Ala Phe Val Phe Leu Val Asn Phe Trp Asp Val Val Lys Arg Gln 35 40 45 gca ctg agc aac agt gat tgt gtg ctg ctg tgt ctc agc atc agc cgg 192 Ala Leu Ser Asn Ser Asp Cys Val Leu Leu Cys Leu Ser Ile Ser Arg 50 55 60 ctt ttc ctg cat gga ctg ctg ttc ctg agt gct atc cag ctt acc cac 240 Leu Phe Leu His Gly Leu Leu Phe Leu Ser Ala Ile Gln Leu Thr His 65 70 75 80 ttc cag aag ttg agt gaa cca ctg aac cac agc tac caa gcc atc atc 288 Phe Gln Lys Leu Ser Glu Pro Leu Asn His Ser Tyr Gln Ala Ile Ile 85 90 95 atg cta tgg atg att gca aac caa gcc aac ctc tgg ctt gct gcc tgc 336 Met Leu Trp Met Ile Ala Asn Gln Ala Asn Leu Trp Leu Ala Ala Cys 100 105 110 ctc agc ctg ctt tac tgc tcc aag ctc atc cgt ttc tct cac acc ttc 384 Leu Ser Leu Leu Tyr Cys Ser Lys Leu Ile Arg Phe Ser His Thr Phe 115 120 125 ctg atc tgc ttg gca agc tgg gtc tcc agg aag atc tcc cag atg ctc 432 Leu Ile Cys Leu Ala Ser Trp Val Ser Arg Lys Ile Ser Gln Met Leu 130 135 140 ctg ggt att att ctt tgc tcc tgc atc tgc act gtc ctc tgt gtt tgg 480 Leu Gly Ile Ile Leu Cys Ser Cys Ile Cys Thr Val Leu Cys Val Trp 145 150 155 160 tgc ttt ttt agc aga cct cac ttc aca gtc aca act gtg cta ttc atg 528 Cys Phe Phe Ser Arg Pro His Phe Thr Val Thr Thr Val Leu Phe Met 165 170 175 aat aac aat aca agg ctc aac tgg cag att aaa gat ctc aat tta ttt 576 Asn Asn Asn Thr Arg Leu Asn Trp Gln Ile Lys Asp Leu Asn Leu Phe 180 185 190 tat tcc ttt ctc ttc tgc tat ctg tgg tct gtg cct cct ttc cta ttg 624 Tyr Ser Phe Leu Phe Cys Tyr Leu Trp Ser Val Pro Pro Phe Leu Leu 195 200 205 ttt ctg gtt tct tct ggg atg ctg act gtc tcc ctg gga agg cac atg 672 Phe Leu Val Ser Ser Gly Met Leu Thr Val Ser Leu Gly Arg His Met 210 215 220 agg aca atg aag gtc tat acc aga aac tct cgt gac ccc agc ctg gag 720 Arg Thr Met Lys Val Tyr Thr Arg Asn Ser Arg Asp Pro Ser Leu Glu 225 230 235 240 gcc cac att aaa gcc ctc aag tct ctt gtc tcc ttt ttc tgc ttc ttt 768 Ala His Ile Lys Ala Leu Lys Ser Leu Val Ser Phe Phe Cys Phe Phe 245 250 255 gtg ata tca tcc tgt gtt gcc ttc atc tct gtg ccc cta ctg att ctg 816 Val Ile Ser Ser Cys Val Ala Phe Ile Ser Val Pro Leu Leu Ile Leu 260 265 270 tgg cgc gac aaa ata ggg gtg atg gtt tgt gtt ggg ata atg gca gct 864 Trp Arg Asp Lys Ile Gly Val Met Val Cys Val Gly Ile Met Ala Ala 275 280 285 tgt ccc tct ggg cat gca gcc atc ctg atc tca ggc aat gcc aag ttg 912 Cys Pro Ser Gly His Ala Ala Ile Leu Ile Ser Gly Asn Ala Lys Leu 290 295 300 agg aga gct gtg atg acc att ctg ctc tgg gct cag agc agc ctg aag 960 Arg Arg Ala Val Met Thr Ile Leu Leu Trp Ala Gln Ser Ser Leu Lys 305 310 315 320 gta aga gcc gac cac aag gca gat tcc cgg aca ctg tgc tga 1002 Val Arg Ala Asp His Lys Ala Asp Ser Arg Thr Leu Cys 325 330 <210> 666 <211> 333 <212> PRT <213> Homo sapiens <400> 666 Met Leu Thr Leu Thr Arg Ile Arg Thr Val Ser Tyr Glu Val Arg Ser 1 5 10 15 Thr Phe Leu Phe Ile Ser Val Leu Glu Phe Ala Val Gly Phe Leu Thr 20 25 30 Asn Ala Phe Val Phe Leu Val Asn Phe Trp Asp Val Val Lys Arg Gln 35 40 45 Ala Leu Ser Asn Ser Asp Cys Val Leu Leu Cys Leu Ser Ile Ser Arg 50 55 60 Leu Phe Leu His Gly Leu Leu Phe Leu Ser Ala Ile Gln Leu Thr His 65 70 75 80 Phe Gln Lys Leu Ser Glu Pro Leu Asn His Ser Tyr Gln Ala Ile Ile 85 90 95 Met Leu Trp Met Ile Ala Asn Gln Ala Asn Leu Trp Leu Ala Ala Cys 100 105 110 Leu Ser Leu Leu Tyr Cys Ser Lys Leu Ile Arg Phe Ser His Thr Phe 115 120 125 Leu Ile Cys Leu Ala Ser Trp Val Ser Arg Lys Ile Ser Gln Met Leu 130 135 140 Leu Gly Ile Ile Leu Cys Ser Cys Ile Cys Thr Val Leu Cys Val Trp 145 150 155 160 Cys Phe Phe Ser Arg Pro His Phe Thr Val Thr Thr Val Leu Phe Met 165 170 175 Asn Asn Asn Thr Arg Leu Asn Trp Gln Ile Lys Asp Leu Asn Leu Phe 180 185 190 Tyr Ser Phe Leu Phe Cys Tyr Leu Trp Ser Val Pro Pro Phe Leu Leu 195 200 205 Phe Leu Val Ser Ser Gly Met Leu Thr Val Ser Leu Gly Arg His Met 210 215 220 Arg Thr Met Lys Val Tyr Thr Arg Asn Ser Arg Asp Pro Ser Leu Glu 225 230 235 240 Ala His Ile Lys Ala Leu Lys Ser Leu Val Ser Phe Phe Cys Phe Phe 245 250 255 Val Ile Ser Ser Cys Val Ala Phe Ile Ser Val Pro Leu Leu Ile Leu 260 265 270 Trp Arg Asp Lys Ile Gly Val Met Val Cys Val Gly Ile Met Ala Ala 275 280 285 Cys Pro Ser Gly His Ala Ala Ile Leu Ile Ser Gly Asn Ala Lys Leu 290 295 300 Arg Arg Ala Val Met Thr Ile Leu Leu Trp Ala Gln Ser Ser Leu Lys 305 310 315 320 Val Arg Ala Asp His Lys Ala Asp Ser Arg Thr Leu Cys 325 330 <210> 667 <211> 960 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(960) <400> 667 atg ata act ttt ctg ccc atc att ttt tcc att cta ata gtg gtt ata 48 Met Ile Thr Phe Leu Pro Ile Ile Phe Ser Ile Leu Ile Val Val Ile 1 5 10 15 ttt gtg att gga aat ttt gct aat ggc ttc ata gca ttg gta aat tcc 96 Phe Val Ile Gly Asn Phe Ala Asn Gly Phe Ile Ala Leu Val Asn Ser 20 25 30 att gag tgg gtc aag aga caa aag atc tcc ttt gtt gac caa att ctc 144 Ile Glu Trp Val Lys Arg Gln Lys Ile Ser Phe Val Asp Gln Ile Leu 35 40 45 act gct ctg gcg gtc tcc aga gtt ggt ttg ctc tgg gtg tta tta cta 192 Thr Ala Leu Ala Val Ser Arg Val Gly Leu Leu Trp Val Leu Leu Leu 50 55 60 cat tgg tat gca act cag ttg aat cca gct ttt tat agt gta gaa gta 240 His Trp Tyr Ala Thr Gln Leu Asn Pro Ala Phe Tyr Ser Val Glu Val 65 70 75 80 aga att act gct tat aat gtc tgg gca gta acc aac cat ttc agc agc 288 Arg Ile Thr Ala Tyr Asn Val Trp Ala Val Thr Asn His Phe Ser Ser 85 90 95 tgg ctt gct act agc ctc agc atg ttt tat ttg ctc agg att gcc aat 336 Trp Leu Ala Thr Ser Leu Ser Met Phe Tyr Leu Leu Arg Ile Ala Asn 100 105 110 ttc tcc aac ctt att ttt ctt cgc ata aag agg aga gtt aag agt gtt 384 Phe Ser Asn Leu Ile Phe Leu Arg Ile Lys Arg Arg Val Lys Ser Val 115 120 125 gtt ctg gtg ata ctg ttg ggg cct ttg cta ttt ttg gtt tgt cat ctt 432 Val Leu Val Ile Leu Leu Gly Pro Leu Leu Phe Leu Val Cys His Leu 130 135 140 ttt gtg ata aac atg gat gag act gta tgg aca aaa gaa tat gaa gga 480 Phe Val Ile Asn Met Asp Glu Thr Val Trp Thr Lys Glu Tyr Glu Gly 145 150 155 160 aac gtg act tgg aag atc aaa ttg agg agt gca atg tac cat tca aat 528 Asn Val Thr Trp Lys Ile Lys Leu Arg Ser Ala Met Tyr His Ser Asn 165 170 175 atg act cta acc atg cta gca aac ttt gta ccc ctc act ctg acc ctg 576 Met Thr Leu Thr Met Leu Ala Asn Phe Val Pro Leu Thr Leu Thr Leu 180 185 190 ata tct ttt ctg ctg tta atc tgt tct ctg tgt aaa cat ctc aag aag 624 Ile Ser Phe Leu Leu Leu Ile Cys Ser Leu Cys Lys His Leu Lys Lys 195 200 205 atg cag ctc cat ggc aaa gga tct caa gat ccc agc acc aag gtc cac 672 Met Gln Leu His Gly Lys Gly Ser Gln Asp Pro Ser Thr Lys Val His 210 215 220 ata aaa gct ttg caa act gtg acc tcc ttt ctt ctg tta tgt gcc att 720 Ile Lys Ala Leu Gln Thr Val Thr Ser Phe Leu Leu Leu Cys Ala Ile 225 230 235 240 tac ttt ctg tcc atg atc ata tca gtt tgt aat ttg ggg agg ctg gaa 768 Tyr Phe Leu Ser Met Ile Ile Ser Val Cys Asn Leu Gly Arg Leu Glu 245 250 255 aag caa cct gtc ttc atg ttc tgc caa gct att ata ttc agc tat cct 816 Lys Gln Pro Val Phe Met Phe Cys Gln Ala Ile Ile Phe Ser Tyr Pro 260 265 270 tca acc cac cca ttc atc ctg att ttg gga aac aag aag cta aag cag 864 Ser Thr His Pro Phe Ile Leu Ile Leu Gly Asn Lys Lys Leu Lys Gln 275 280 285 att ttt ctt tca gtt ttg cgg cat gtg agg tac tgg gtg aaa gac aga 912 Ile Phe Leu Ser Val Leu Arg His Val Arg Tyr Trp Val Lys Asp Arg 290 295 300 agc ctt cgt ctc cat aga ttc aca aga ggg gca ttg tgt gtc ttc tag 960 Ser Leu Arg Leu His Arg Phe Thr Arg Gly Ala Leu Cys Val Phe 305 310 315 320 <210> 668 <211> 319 <212> PRT <213> Homo sapiens <400> 668 Met Ile Thr Phe Leu Pro Ile Ile Phe Ser Ile Leu Ile Val Val Ile 1 5 10 15 Phe Val Ile Gly Asn Phe Ala Asn Gly Phe Ile Ala Leu Val Asn Ser 20 25 30 Ile Glu Trp Val Lys Arg Gln Lys Ile Ser Phe Val Asp Gln Ile Leu 35 40 45 Thr Ala Leu Ala Val Ser Arg Val Gly Leu Leu Trp Val Leu Leu Leu 50 55 60 His Trp Tyr Ala Thr Gln Leu Asn Pro Ala Phe Tyr Ser Val Glu Val 65 70 75 80 Arg Ile Thr Ala Tyr Asn Val Trp Ala Val Thr Asn His Phe Ser Ser 85 90 95 Trp Leu Ala Thr Ser Leu Ser Met Phe Tyr Leu Leu Arg Ile Ala Asn 100 105 110 Phe Ser Asn Leu Ile Phe Leu Arg Ile Lys Arg Arg Val Lys Ser Val 115 120 125 Val Leu Val Ile Leu Leu Gly Pro Leu Leu Phe Leu Val Cys His Leu 130 135 140 Phe Val Ile Asn Met Asp Glu Thr Val Trp Thr Lys Glu Tyr Glu Gly 145 150 155 160 Asn Val Thr Trp Lys Ile Lys Leu Arg Ser Ala Met Tyr His Ser Asn 165 170 175 Met Thr Leu Thr Met Leu Ala Asn Phe Val Pro Leu Thr Leu Thr Leu 180 185 190 Ile Ser Phe Leu Leu Leu Ile Cys Ser Leu Cys Lys His Leu Lys Lys 195 200 205 Met Gln Leu His Gly Lys Gly Ser Gln Asp Pro Ser Thr Lys Val His 210 215 220 Ile Lys Ala Leu Gln Thr Val Thr Ser Phe Leu Leu Leu Cys Ala Ile 225 230 235 240 Tyr Phe Leu Ser Met Ile Ile Ser Val Cys Asn Leu Gly Arg Leu Glu 245 250 255 Lys Gln Pro Val Phe Met Phe Cys Gln Ala Ile Ile Phe Ser Tyr Pro 260 265 270 Ser Thr His Pro Phe Ile Leu Ile Leu Gly Asn Lys Lys Leu Lys Gln 275 280 285 Ile Phe Leu Ser Val Leu Arg His Val Arg Tyr Trp Val Lys Asp Arg 290 295 300 Ser Leu Arg Leu His Arg Phe Thr Arg Gly Ala Leu Cys Val Phe 305 310 315 <210> 669 <211> 900 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(900) <400> 669 atg ata act ttt ctg ccc atc ata ttt tcc att cta gta gtg gtt aca 48 Met Ile Thr Phe Leu Pro Ile Ile Phe Ser Ile Leu Val Val Val Thr 1 5 10 15 ttt gtt att gga aat ttt gct aat ggc ttc ata gcg ttg gta aat tcc 96 Phe Val Ile Gly Asn Phe Ala Asn Gly Phe Ile Ala Leu Val Asn Ser 20 25 30 acc gag tgg gtg aag aga caa aag atc tcc ttt gct gac caa att gtc 144 Thr Glu Trp Val Lys Arg Gln Lys Ile Ser Phe Ala Asp Gln Ile Val 35 40 45 act gct ctg gcg gtc tcc aga gtt ggt ttg ctc tgg gtg tta tta tta 192 Thr Ala Leu Ala Val Ser Arg Val Gly Leu Leu Trp Val Leu Leu Leu 50 55 60 aat tgg tat tca act gtg ttg aat cca gct ttt tat agt gta gaa tta 240 Asn Trp Tyr Ser Thr Val Leu Asn Pro Ala Phe Tyr Ser Val Glu Leu 65 70 75 80 aga act act gct tat aat atc tgg gca gta acc ggc cat ttc agc aac 288 Arg Thr Thr Ala Tyr Asn Ile Trp Ala Val Thr Gly His Phe Ser Asn 85 90 95 tgg cct gct act agc ctc agc ata ttt tat ttg ctc aag att gcc aat 336 Trp Pro Ala Thr Ser Leu Ser Ile Phe Tyr Leu Leu Lys Ile Ala Asn 100 105 110 ttc tcc aac ctt att ttt ctt cgc tta aag agg aga gtt aag agt gtc 384 Phe Ser Asn Leu Ile Phe Leu Arg Leu Lys Arg Arg Val Lys Ser Val 115 120 125 att ctg gtg gtg ctg ttg ggg cct ttg cta ttt ttg gct tgt cat ctt 432 Ile Leu Val Val Leu Leu Gly Pro Leu Leu Phe Leu Ala Cys His Leu 130 135 140 ttt gtg gta aac atg aat cag att gta tgg aca aaa gaa tat gaa gga 480 Phe Val Val Asn Met Asn Gln Ile Val Trp Thr Lys Glu Tyr Glu Gly 145 150 155 160 aac atg act tgg aag atc aaa ttg agg cgt gca atg tac ctt tca gat 528 Asn Met Thr Trp Lys Ile Lys Leu Arg Arg Ala Met Tyr Leu Ser Asp 165 170 175 acg act gta acc atg cta gca aac tta gta ccc ttt act gta acc ctg 576 Thr Thr Val Thr Met Leu Ala Asn Leu Val Pro Phe Thr Val Thr Leu 180 185 190 ata tct ttt ctg ctg tta gtc tgt tct ctg tgt aaa cat ctc aag aag 624 Ile Ser Phe Leu Leu Leu Val Cys Ser Leu Cys Lys His Leu Lys Lys 195 200 205 atg cag ctc cat ggc aaa gga tct caa gat ccc agt acc aag gtc cac 672 Met Gln Leu His Gly Lys Gly Ser Gln Asp Pro Ser Thr Lys Val His 210 215 220 ata aaa gtt ttg caa act gtg atc tcc ttc ttc ttg tta tgt gcc att 720 Ile Lys Val Leu Gln Thr Val Ile Ser Phe Phe Leu Leu Cys Ala Ile 225 230 235 240 tac ttt gtg tct gta ata ata tca gtt tgg agt ttt aag aat ctg gaa 768 Tyr Phe Val Ser Val Ile Ile Ser Val Trp Ser Phe Lys Asn Leu Glu 245 250 255 aac aaa cct gtc ttc atg ttc tgc caa gct att gga ttc agc tgt tct 816 Asn Lys Pro Val Phe Met Phe Cys Gln Ala Ile Gly Phe Ser Cys Ser 260 265 270 tca gcc cac ccg ttc atc ctg att tgg gga aac aag aag cta aag cag 864 Ser Ala His Pro Phe Ile Leu Ile Trp Gly Asn Lys Lys Leu Lys Gln 275 280 285 act tat ctt tca gtt ttg tgg caa atg agg tac tga 900 Thr Tyr Leu Ser Val Leu Trp Gln Met Arg Tyr 290 295 300 <210> 670 <211> 299 <212> PRT <213> Homo sapiens <400> 670 Met Ile Thr Phe Leu Pro Ile Ile Phe Ser Ile Leu Val Val Val Thr 1 5 10 15 Phe Val Ile Gly Asn Phe Ala Asn Gly Phe Ile Ala Leu Val Asn Ser 20 25 30 Thr Glu Trp Val Lys Arg Gln Lys Ile Ser Phe Ala Asp Gln Ile Val 35 40 45 Thr Ala Leu Ala Val Ser Arg Val Gly Leu Leu Trp Val Leu Leu Leu 50 55 60 Asn Trp Tyr Ser Thr Val Leu Asn Pro Ala Phe Tyr Ser Val Glu Leu 65 70 75 80 Arg Thr Thr Ala Tyr Asn Ile Trp Ala Val Thr Gly His Phe Ser Asn 85 90 95 Trp Pro Ala Thr Ser Leu Ser Ile Phe Tyr Leu Leu Lys Ile Ala Asn 100 105 110 Phe Ser Asn Leu Ile Phe Leu Arg Leu Lys Arg Arg Val Lys Ser Val 115 120 125 Ile Leu Val Val Leu Leu Gly Pro Leu Leu Phe Leu Ala Cys His Leu 130 135 140 Phe Val Val Asn Met Asn Gln Ile Val Trp Thr Lys Glu Tyr Glu Gly 145 150 155 160 Asn Met Thr Trp Lys Ile Lys Leu Arg Arg Ala Met Tyr Leu Ser Asp 165 170 175 Thr Thr Val Thr Met Leu Ala Asn Leu Val Pro Phe Thr Val Thr Leu 180 185 190 Ile Ser Phe Leu Leu Leu Val Cys Ser Leu Cys Lys His Leu Lys Lys 195 200 205 Met Gln Leu His Gly Lys Gly Ser Gln Asp Pro Ser Thr Lys Val His 210 215 220 Ile Lys Val Leu Gln Thr Val Ile Ser Phe Phe Leu Leu Cys Ala Ile 225 230 235 240 Tyr Phe Val Ser Val Ile Ile Ser Val Trp Ser Phe Lys Asn Leu Glu 245 250 255 Asn Lys Pro Val Phe Met Phe Cys Gln Ala Ile Gly Phe Ser Cys Ser 260 265 270 Ser Ala His Pro Phe Ile Leu Ile Trp Gly Asn Lys Lys Leu Lys Gln 275 280 285 Thr Tyr Leu Ser Val Leu Trp Gln Met Arg Tyr 290 295 <210> 671 <211> 945 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(945) <400> 671 atg gcc acc gaa ttg gac aaa atc ttt ctg att ctg gca ata gca gaa 48 Met Ala Thr Glu Leu Asp Lys Ile Phe Leu Ile Leu Ala Ile Ala Glu 1 5 10 15 ttc atc atc agc atg ctg ggg aat gtg ttc att gga ctg gta aac tgc 96 Phe Ile Ile Ser Met Leu Gly Asn Val Phe Ile Gly Leu Val Asn Cys 20 25 30 tct gaa ggg atc aag aac caa aag gtc ttc tca gct gac ttc atc ctc 144 Ser Glu Gly Ile Lys Asn Gln Lys Val Phe Ser Ala Asp Phe Ile Leu 35 40 45 acc tgc ttg gct atc tcc aca att gga caa ctg ttg gtg ata ctg ttt 192 Thr Cys Leu Ala Ile Ser Thr Ile Gly Gln Leu Leu Val Ile Leu Phe 50 55 60 gat tca ttt cta gtg gga ctt gct tca cat tta tat acc aca tat aga 240 Asp Ser Phe Leu Val Gly Leu Ala Ser His Leu Tyr Thr Thr Tyr Arg 65 70 75 80 cta gga aaa act gtt att atg ctt tgg cac atg act aat cac ttg aca 288 Leu Gly Lys Thr Val Ile Met Leu Trp His Met Thr Asn His Leu Thr 85 90 95 acc tgg ctt gcc acc tgc cta agc att ttc tat ttc ttt aag ata gcc 336 Thr Trp Leu Ala Thr Cys Leu Ser Ile Phe Tyr Phe Phe Lys Ile Ala 100 105 110 cac ttc ccc cac tcc ctt ttc ctc tgg ctg agg tgg agg atg aac gga 384 His Phe Pro His Ser Leu Phe Leu Trp Leu Arg Trp Arg Met Asn Gly 115 120 125 atg att gtt atg ctt ctt ata ttg tct ttg ttc tta ctg att ttt gac 432 Met Ile Val Met Leu Leu Ile Leu Ser Leu Phe Leu Leu Ile Phe Asp 130 135 140 agt tta gtg cta gaa ata ttt att gat atc tca ctc aat ata ata gat 480 Ser Leu Val Leu Glu Ile Phe Ile Asp Ile Ser Leu Asn Ile Ile Asp 145 150 155 160 aaa agt aat ctg act tta tat tta gat gaa agt aaa act ctc tat gat 528 Lys Ser Asn Leu Thr Leu Tyr Leu Asp Glu Ser Lys Thr Leu Tyr Asp 165 170 175 aaa ctc tct att tta aaa act ctt ctc agc ttg acc agt ttt atc ccc 576 Lys Leu Ser Ile Leu Lys Thr Leu Leu Ser Leu Thr Ser Phe Ile Pro 180 185 190 ttt tct ctg ttc ctg acc tcc ttg ctt ttt tta ttt ctg tcc ttg gtg 624 Phe Ser Leu Phe Leu Thr Ser Leu Leu Phe Leu Phe Leu Ser Leu Val 195 200 205 aga cat act aga aat ttg aag ctc agt tcc ttg ggc tct aga gac tcc 672 Arg His Thr Arg Asn Leu Lys Leu Ser Ser Leu Gly Ser Arg Asp Ser 210 215 220 agc aca gag gcc cat agg agg gcc atg aaa atg gtg atg tct ttc ctt 720 Ser Thr Glu Ala His Arg Arg Ala Met Lys Met Val Met Ser Phe Leu 225 230 235 240 ttc ctc ttc ata gtt cat ttt ttt tcc tta caa gtg gcc aat tgg ata 768 Phe Leu Phe Ile Val His Phe Phe Ser Leu Gln Val Ala Asn Trp Ile 245 250 255 ttt ttt atg ttg tgg aac aac aag tgc ata aag ttt gtc atg tta gcc 816 Phe Phe Met Leu Trp Asn Asn Lys Cys Ile Lys Phe Val Met Leu Ala 260 265 270 tta aat gcc ttt ccc tcg tgc cac tca ttt att ctc att ctg gga aac 864 Leu Asn Ala Phe Pro Ser Cys His Ser Phe Ile Leu Ile Leu Gly Asn 275 280 285 agc aag ctg caa cag aca gct gtg agg cta ctg tgg cat ctt agg aac 912 Ser Lys Leu Gln Gln Thr Ala Val Arg Leu Leu Trp His Leu Arg Asn 290 295 300 tat aca aaa aca cca aac cct tta cct ttg tag 945 Tyr Thr Lys Thr Pro Asn Pro Leu Pro Leu 305 310 315 <210> 672 <211> 314 <212> PRT <213> Homo sapiens <400> 672 Met Ala Thr Glu Leu Asp Lys Ile Phe Leu Ile Leu Ala Ile Ala Glu 1 5 10 15 Phe Ile Ile Ser Met Leu Gly Asn Val Phe Ile Gly Leu Val Asn Cys 20 25 30 Ser Glu Gly Ile Lys Asn Gln Lys Val Phe Ser Ala Asp Phe Ile Leu 35 40 45 Thr Cys Leu Ala Ile Ser Thr Ile Gly Gln Leu Leu Val Ile Leu Phe 50 55 60 Asp Ser Phe Leu Val Gly Leu Ala Ser His Leu Tyr Thr Thr Tyr Arg 65 70 75 80 Leu Gly Lys Thr Val Ile Met Leu Trp His Met Thr Asn His Leu Thr 85 90 95 Thr Trp Leu Ala Thr Cys Leu Ser Ile Phe Tyr Phe Phe Lys Ile Ala 100 105 110 His Phe Pro His Ser Leu Phe Leu Trp Leu Arg Trp Arg Met Asn Gly 115 120 125 Met Ile Val Met Leu Leu Ile Leu Ser Leu Phe Leu Leu Ile Phe Asp 130 135 140 Ser Leu Val Leu Glu Ile Phe Ile Asp Ile Ser Leu Asn Ile Ile Asp 145 150 155 160 Lys Ser Asn Leu Thr Leu Tyr Leu Asp Glu Ser Lys Thr Leu Tyr Asp 165 170 175 Lys Leu Ser Ile Leu Lys Thr Leu Leu Ser Leu Thr Ser Phe Ile Pro 180 185 190 Phe Ser Leu Phe Leu Thr Ser Leu Leu Phe Leu Phe Leu Ser Leu Val 195 200 205 Arg His Thr Arg Asn Leu Lys Leu Ser Ser Leu Gly Ser Arg Asp Ser 210 215 220 Ser Thr Glu Ala His Arg Arg Ala Met Lys Met Val Met Ser Phe Leu 225 230 235 240 Phe Leu Phe Ile Val His Phe Phe Ser Leu Gln Val Ala Asn Trp Ile 245 250 255 Phe Phe Met Leu Trp Asn Asn Lys Cys Ile Lys Phe Val Met Leu Ala 260 265 270 Leu Asn Ala Phe Pro Ser Cys His Ser Phe Ile Leu Ile Leu Gly Asn 275 280 285 Ser Lys Leu Gln Gln Thr Ala Val Arg Leu Leu Trp His Leu Arg Asn 290 295 300 Tyr Thr Lys Thr Pro Asn Pro Leu Pro Leu 305 310 <210> 673 <211> 972 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(972) <400> 673 atg gca acg gtg aac aca gat gcc aca gat aaa gac ata tcc aag ttc 48 Met Ala Thr Val Asn Thr Asp Ala Thr Asp Lys Asp Ile Ser Lys Phe 1 5 10 15 aag gtc acc ttc act ttg gtg gtc tcc gga ata gag tgc atc act ggc 96 Lys Val Thr Phe Thr Leu Val Val Ser Gly Ile Glu Cys Ile Thr Gly 20 25 30 atc ctt ggg agt ggc ttc atc acg gcc atc tat ggg gct gag tgg gcc 144 Ile Leu Gly Ser Gly Phe Ile Thr Ala Ile Tyr Gly Ala Glu Trp Ala 35 40 45 agg ggc aaa aca ctc ccc act ggt gac cgc att atg ttg atg ctg agc 192 Arg Gly Lys Thr Leu Pro Thr Gly Asp Arg Ile Met Leu Met Leu Ser 50 55 60 ttt tcc agg ctc ttg cta cag att tgg atg atg ctg gag aac att ttc 240 Phe Ser Arg Leu Leu Leu Gln Ile Trp Met Met Leu Glu Asn Ile Phe 65 70 75 80 agt ctg cta ttc cga att gtt tat aac caa aac tca gtg tat atc ctc 288 Ser Leu Leu Phe Arg Ile Val Tyr Asn Gln Asn Ser Val Tyr Ile Leu 85 90 95 ttc aaa gtc atc act gtc ttt ctg aac cat tcc aat ctc tgg ttt gct 336 Phe Lys Val Ile Thr Val Phe Leu Asn His Ser Asn Leu Trp Phe Ala 100 105 110 gcc tgg ctc aaa gtc ttc tat tgt ctt aga att gca aac ttc aat cat 384 Ala Trp Leu Lys Val Phe Tyr Cys Leu Arg Ile Ala Asn Phe Asn His 115 120 125 cct ttg ttc ttc ctg atg aag agg aaa atc ata gtg ctg atg cct tgg 432 Pr o Leu Phe Phe Leu Met Lys Arg Lys Ile Ile Val Leu Met Pro Trp 130 135 140 ctt ctc agg ctg tca gtg ttg gtt tcc tta agc ttc agc ttt cct ctc 480 Leu Leu Arg Leu Ser Val Leu Val Ser Leu Ser Phe Ser Phe Pro Leu 145 150 155 160 tcg aga gat gtc ttc aat gtg tat gtg aat agc tcc att cct atc ccc 528 Ser Arg Asp Val Phe Asn Val Tyr Val Asn Ser Ser Ile Pro Ile Pro 165 170 175 tcc tcc aac tcc acg gag aag aag tac ttc tct gag acc aat atg gtc 576 Ser Ser Asn Ser Thr Glu Lys Lys Tyr Phe Ser Glu Thr Asn Met Val 180 185 190 aac ctg gta ttt ttc tat aac atg ggg atc ttc gtt cct ctg atc atg 624 Asn Leu Val Phe Phe Tyr Asn Met Gly Ile Phe Val Pro Leu Ile Met 195 200 205 ttc atc ctg gca gcc acc ctg ctg atc ctc tct ctc aag aga cac acc 672 Phe Ile Leu Ala Ala Thr Leu Leu Ile Leu Ser Leu Lys Arg His Thr 210 215 220 cta cac atg gga agc aat gcc aca ggg tcc agg gac ccc agc atg aag 720 Leu His Met Gly Ser Asn Ala Thr Gly Ser Arg Asp Pro Ser Met Lys 225 230 235 240 gct cac ata ggg gcc atc aaa gcc acc agc tac ttt ctc atc ctc tac 768 Ala His Ile Gly Ala Ile Lys Ala Thr Ser Tyr Phe Leu Ile Leu Tyr 245 250 255 att ttc aat gca att gct cta ttt ctt tcc acg tcc aac atc ttt gac 816 Ile Phe Asn Ala Ile Ala Leu Phe Leu Ser Thr Ser Asn Ile Phe Asp 260 265 270 act tac agt tcc tgg aat att ttg tgc aag atc atc atg gct gcc tac 864 Thr Tyr Ser Ser Trp Asn Ile Leu Cys Lys Ile Ile Met Ala Ala Tyr 275 280 285 cct gcc ggc cac tca gta caa ctg atc ttg ggc aac cct ggg ctg aga 912 Pro Ala Gly His Ser Val Gln Leu Ile Leu Gly Asn Pro Gly Leu Arg 290 295 300 aga gcc tgg aag cgg ttt cag cac caa gtt cct ctt tac cta aaa ggg 960 Arg Ala Trp Lys Arg Phe Gln His Gln Val Pro Leu Tyr Leu Lys Gly 305 310 315 320 cag act ctg tga 972 Gln Thr Leu <210> 674 <211> 323 <212> PRT <213> Homo sapiens <400> 674 Met Ala Thr Val Asn Thr Asp Ala Thr Asp Lys Asp Ile Ser Lys Phe 1 5 10 15 Lys Val Thr Phe Thr Leu Val Val Ser Gly Ile Glu Cys Ile Thr Gly 20 25 30 Ile Leu Gly Ser Gly Phe Ile Thr Ala Ile Tyr Gly Ala Glu Trp Ala 35 40 45 Arg Gly Lys Thr Leu Pro Thr Gly Asp Arg Ile Met Leu Met Leu Ser 50 55 60 Phe Ser Arg Leu Leu Leu Gln Ile Trp Met Met Leu Glu Asn Ile Phe 65 70 75 80 Ser Leu Leu Phe Arg Ile Val Tyr Asn Gln Asn Ser Val Tyr Ile Leu 85 90 95 Phe Lys Val Ile Thr Val Phe Leu Asn His Ser Asn Leu Trp Phe Ala 100 105 110 Ala Trp Leu Lys Val Phe Tyr Cys Leu Arg Ile Ala Asn Phe Asn His 115 120 125 Pro Leu Phe Phe Leu Met Lys Arg Lys Ile Ile Val Leu Met Pro Trp 130 135 140 Leu Leu Arg Leu Ser Val Leu Val Ser Leu Ser Phe Ser Phe Pro Leu 145 150 155 160 Ser Arg Asp Val Phe Asn Val Tyr Val Asn Ser Ser Ile Pro Ile Pro 165 170 175 Ser Ser Asn Ser Thr Glu Lys Lys Tyr Phe Ser Glu Thr Asn Met Val 180 185 190 Asn Leu Val Phe Phe Tyr Asn Met Gly Ile Phe Val Pro Leu Ile Met 195 200 205 Phe Ile Leu Ala Ala Thr Leu Leu Ile Leu Ser Leu Lys Arg His Thr 210 215 220 Leu His Met Gly Ser Asn Ala Thr Gly Ser Arg Asp Pro Ser Met Lys 225 230 235 240 Ala His Ile Gly Ala Ile Lys Ala Thr Ser Tyr Phe Leu Ile Leu Tyr 245 250 255 Ile Phe Asn Ala Ile Ala Leu Phe Leu Ser Thr Ser Asn Ile Phe Asp 260 265 270 Thr Tyr Ser Ser Trp Asn Ile Leu Cys Lys Ile Ile Met Ala Ala Tyr 275 280 285 Pro Ala Gly His Ser Val Gln Leu Ile Leu Gly Asn Pro Gly Leu Arg 290 295 300 Arg Ala Trp Lys Arg Phe Gln His Gln Val Pro Leu Tyr Leu Lys Gly 305 310 315 320 Gln Thr Leu <210> 675 <211> 1017 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1017) <400> 675 atg cta ggg aga tgt ttt cct cca gac acc aaa gag aag caa cag ctc 48 Met Leu Gly Arg Cys Phe Pro Pro Asp Thr Lys Glu Lys Gln Gln Leu 1 5 10 15 aga atg act aaa ctc tgc gat cct gca gaa agt gaa ttg tcg cca ttt 96 Arg Met Thr Lys Leu Cys Asp Pro Ala Glu Ser Glu Leu Ser Pro Phe 20 25 30 ctc atc acc tta att tta gca gtt tta ctt gct gaa tac ctc att ggt 144 Leu Ile Thr Leu Ile Leu Ala Val Leu Leu Ala Glu Tyr Leu Ile Gly 35 40 45 atc att gca aat ggt ttc atc atg gct ata cat gca gct gaa tgg gtt 192 Ile Ile Ala Asn Gly Phe Ile Met Ala Ile His Ala Ala Glu Trp Val 50 55 60 caa aat aag gca gtt tcc aca agt ggc agg atc ctg gtt ttc ctg agt 240 Gln Asn Lys Ala Val Ser Thr Ser Gly Arg Ile Leu Val Phe Leu Ser 65 70 75 80 gta tcc aga ata gct ctc caa agc ctc atg atg tta gaa att acc atc 288 Val Ser Arg Ile Ala Leu Gln Ser Leu Met Met Leu Glu Ile Thr Ile 85 90 95 agc tca acc tcc cta agt ttt tat tct gaa gac gct gta tat tat gca 336 Ser Ser Thr Ser Leu Ser Phe Tyr Ser Glu Asp Ala Val Tyr Tyr Ala 100 105 110 ttc aaa ata agt ttt ata ttc tta aat ttt tgt agc ctg tgg ttt gct 384 Phe Lys Ile Ser Phe Ile Phe Leu Asn Phe Cys Ser Leu Trp Phe Ala 115 120 125 gcc tgg ctc agt ttc ttc tac ttt gtg aag att gcc aat ttc tcc tac 432 Ala Trp Leu Ser Phe Phe Tyr Phe Val Lys Ile Ala Asn Phe Ser Tyr 130 135 140 ccc ctt ttc ctc aaa ctg agg tgg aga att act gga ttg ata ccc tgg 480 Pro Leu Phe Leu Lys Leu Arg Trp Arg Ile Thr Gly Leu Ile Pro Trp 145 150 155 160 ctt ctg tgg ctg tcc gtg ttt att tcc ttc agt cac agc atg ttc tgc 528 Leu Leu Trp Leu Ser Val Phe Ile Ser Phe Ser His Ser Met Phe Cys 165 170 175 atc aac atc tgc act gtg tat tgt aac aat tct ttc cct atc cac tcc 576 Ile Asn Ile Cys Thr Val Tyr Cys Asn Asn Ser Phe Pro Ile His Ser 180 185 190 tcc aac tcc act aag aaa aca tac ttg tct gag atc aat gtg gtc ggt 624 Ser Asn Ser Thr Lys Lys Thr Tyr Leu Ser Glu Ile Asn Val Val Gly 195 200 205 ctg gct ttt ttc ttt aac ctg ggg att gtg act cct ctg atc atg ttc 672 Leu Ala Phe Phe Phe Asn Leu Gly Ile Val Thr Pro Leu Ile Met Phe 210 215 220 atc ctg aca gcc acc ctg ctg atc ctc tct ctc aag aga cac acc cta 720 Ile Leu Thr Ala Thr Leu Leu Ile Leu Ser Leu Lys Arg His Thr Leu 225 230 235 240 cac atg gga agc aat gcc aca ggg tcc aac gac ccc agc atg gag gct 768 His Met Gly Ser Asn Ala Thr Gly Ser Asn Asp Pro Ser Met Glu Ala 245 250 255 cac atg ggg gcc atc aaa gct atc agc tac ttt ctc att ctc tac att 816 His Met Gly Ala Ile Lys Ala Ile Ser Tyr Phe Leu Ile Leu Tyr Ile 260 265 270 ttc aat gca gtt gct ctg ttt atc tac ctg tcc aac atg ttt gac atc 864 Phe Asn Ala Val Ala Leu Phe Ile Tyr Leu Ser Asn Met Phe Asp Ile 275 280 285 aac agt ctg tgg aat aat ttg tgc cag atc atc atg gct gcc tac cct 912 Asn Ser Leu Trp Asn Asn Leu Cys Gln Ile Ile Met Ala Ala Tyr Pro 290 295 300 gcc agc cac tca att cta ctg att caa gat aac cct ggg ctg aga aga 960 Ala Ser His Ser Ile Leu Leu Ile Gln Asp Asn Pro Gly Leu Arg Arg 305 310 315 320 gcc tgg aag cgg ctt cag ctt cga ctt cat ctt tac cca aaa gag tgg 1008 Ala Trp Lys Arg Leu Gln Leu Arg Leu His Leu Tyr Pro Lys Glu Trp 325 330 335 act ctg tga 1017 Thr Leu <210> 676 <211> 338 <212> PRT <213> Homo sapiens <400> 676 Met Leu Gly Arg Cys Phe Pro Pro Asp Thr Lys Glu Lys Gln Gln Leu 1 5 10 15 Arg Met Thr Lys Leu Cys Asp Pro Ala Glu Ser Glu Leu Ser Pro Phe 20 25 30 Leu Ile Thr Leu Ile Leu Ala Val Leu Leu Ala Glu Tyr Leu Ile Gly 35 40 45 Ile Ile Ala Asn Gly Phe Ile Met Ala Ile His Ala Ala Glu Trp Val 50 55 60 G ln Asn Lys Ala Val Ser Thr Ser Gly Arg Ile Leu Val Phe Leu Ser 65 70 75 80 Val Ser Arg Ile Ala Leu Gln Ser Leu Met Met Leu Glu Ile Thr Ile 85 90 95 Ser Ser Thr Ser Leu Ser Phe Tyr Ser Glu Asp Ala Val Tyr Tyr Ala 100 105 110 Phe Lys Ile Ser Phe Ile Phe Leu Asn Phe Cys Ser Leu Trp Phe Ala 115 120 125 Ala Trp Leu Ser Phe Phe Tyr Phe Val Lys Ile Ala Asn Phe Ser Tyr 130 135 140 Pro Leu Phe Leu Lys Leu Arg Trp Arg Ile Thr Gly Leu Ile Pro Trp 145 150 155 160 Leu Leu Trp Leu Ser Val Phe Ile Ser Phe Ser His Ser Met Phe Cys 165 170 175 Ile Asn Ile Cys Thr Val Tyr Cys Asn Asn Ser Phe Pro Ile His Ser 180 185 190 Ser Asn Ser Thr Lys Lys Thr Tyr Leu Ser Glu Ile Asn Val Val Gly 195 200 205 Leu Ala Phe Phe Phe Asn Leu Gly Ile Val Thr Pro Leu Ile Met Phe 210 215 220 Ile Leu Thr Ala Thr Leu Leu Ile Leu Ser Leu Lys Arg His Thr Leu 225 230 235 240 His Met Gly Ser Asn Ala Thr Gly Ser Asn Asp Pro Ser Met Glu Ala 245 250 255 His Met Gly Ala Ile Lys Ala Ile Ser Tyr Phe Leu Ile Leu Tyr Ile 260 265 270 Phe Asn Ala Val Ala Leu Phe Ile Tyr Leu Ser Asn Met Phe Asp Ile 275 280 285 Asn Ser Leu Trp Asn Asn Leu Cys Gln Ile Ile Met Ala Ala Tyr Pro 290 295 300 Ala Ser His Ser Ile Leu Leu Ile Gln Asp Asn Pro Gly Leu Arg Arg 305 310 315 320 Ala Trp Lys Arg Leu Gln Leu Arg Leu His Leu Tyr Pro Lys Glu Trp 325 330 335 Thr Leu <210> 677 <211> 1017 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1017) <400> 677 atg cta ggg aga tgt ttt cct cca gac acc aaa gag aag caa cag ctc 48 Met Leu Gly Arg Cys Phe Pro Pro Asp Thr Lys Glu Lys Gln Gln Leu 1 5 10 15 aga atg act aaa ctc tgc gat cct gca gaa agt gaa ttg tcg cca ttt 96 Arg Met Thr Lys Leu Cys Asp Pro Ala Glu Ser Glu Leu Ser Pro Phe 20 25 30 ctc atc acc tta att tta gca gtt tta ctt gct gaa tac ctc att ggt 144 Leu Ile Thr Leu Ile Leu Ala Val Leu Leu Ala Glu Tyr Leu Ile Gly 35 40 45 atc att gca aat ggt ttc atc atg gct ata cat gca gct gaa tgg gtt 192 Ile Ile Ala Asn Gly Phe Ile Met Ala Ile His Ala Ala Glu Trp Val 50 55 60 caa aat aag gca gtt tcc aca agt ggc agg atc ctg gtt ttc ctg agt 240 Gln Asn Lys Ala Val Ser Thr Ser Gly Arg Ile Leu Val Phe Leu Ser 65 70 75 80 gta tcc aga ata gct ctc caa agc ctc atg atg tta gaa att acc atc 288 Val Ser Arg Ile Ala Leu Gln Ser Leu Met Met Leu Glu Ile Thr Ile 85 90 95 agc tca acc tcc cta agt ttt tat tct gaa gac gct gta tat tat gca 336 Ser Ser Thr Ser Leu Ser Phe Tyr Ser Glu Asp Ala Val Tyr Tyr Ala 100 105 110 ttc aaa ata agt ttt ata ttc tta aat ttt tgt agc ctg tgg ttt gct 384 Phe Lys Ile Ser Phe Ile Phe Leu Asn Phe Cys Ser Leu Trp Phe Ala 115 120 125 gcc tgg ctc agt ttc ttc tac ttt gtg aag att gcc aat ttc tcc tac 432 Ala Trp Leu Ser Phe Phe Tyr Phe Val Lys Ile Ala Asn Phe Ser Tyr 130 135 140 ccc ctt ttc ctc aaa ctg agg tgg aga att act gga ttg ata ccc tgg 480 Pro Leu Phe Leu Lys Leu Arg Trp Arg Ile Thr Gly Leu Ile Pro Trp 145 150 155 160 ctt ctg tgg ctg tcc gtg ttt att tcc ttc agt cac agc atg ttc tgc 528 Leu Leu Trp Leu Ser Val Phe Ile Ser Phe Ser His Ser Met Phe Cys 165 170 175 atc aac atc tgc act gtg tat tgt aac aat tct ttc cct atc cac tcc 576 Ile Asn Ile Cys Thr Val Tyr Cys Asn Asn Ser Phe Pro Ile His Ser 180 185 190 tcc aac tcc act aag aaa aca tac ttg tct gag atc aat gtg gtc ggt 624 Ser Asn Ser Thr Lys Lys Thr Tyr Leu Ser Glu Ile Asn Val Val Gly 195 200 205 ctg gct ttt ttc ttt aac ctg ggg att gtg act cct ctg atc atg ttc 672 Leu Ala Phe Phe Phe Asn Leu Gly Ile Val Thr Pro Leu Ile Met Phe 210 215 220 atc ctg aca gcc acc ctg ctg atc ctc tct ctc aag aga cac acc cta 720 Ile Leu Thr Ala Thr Leu Leu Ile Leu Ser Leu Lys Arg His Thr Leu 22 5 230 235 240 cac atg gga agc aat gcc aca ggg tcc aac gac ccc agc atg gag gct 768 His Met Gly Ser Asn Ala Thr Gly Ser Asn Asp Pro Ser Met Glu Ala 245 250 255 cac ata ggg gcc atc aaa gct atc agc tac ttt ctc atc ctc tac att 816 His Ile Gly Ala Ile Lys Ala Ile Ser Tyr Phe Leu Ile Leu Tyr Ile 260 265 270 ttc aat gca att gct cta ttt ctt tcc acg tcc aac atc ttt gac act 864 Phe Asn Ala Ile Ala Leu Phe Leu Ser Thr Ser Asn Ile Phe Asp Thr 275 280 285 tac agt tcc tgg aat att ttg tgc aag atc atc atg gct gcc tac cct 912 Tyr Ser Ser Trp Asn Ile Leu Cys Lys Ile Ile Met Ala Ala Tyr Pro 290 295 300 gcc ggc cac tca gta caa ctg atc ttg ggc aac cct ggg ctg aga aga 960 Ala Gly His Ser Val Gln Leu Ile Leu Gly Asn Pro Gly Leu Arg Arg 305 310 315 320 gcc tgg aag cgg ttt cag cac caa gtt cct ctt tac cta aaa ggg cag 1008 Ala Trp Lys Arg Phe Gln His Gln Val Pro Leu Tyr Leu Lys Gly Gln 325 330 335 act ctg tga 1017 Thr Leu <210> 678 <211> 338 <212> PRT <213> Homo sapiens <400> 678 Met Leu Gly Arg Cys Phe Pro Pro Asp Thr Lys Glu Lys Gln Gln Leu 1 5 10 15 Arg Met Thr Lys Leu Cys Asp Pro Ala Glu Ser Glu Leu Ser Pro Phe 20 25 30 Leu Ile Thr Leu Ile Leu Ala Val Leu Leu Ala Glu Tyr Leu Ile Gly 35 40 45 Ile Ile Ala Asn Gly Phe Ile Met Ala Ile His Ala Ala Glu Trp Val 50 55 60 Gln Asn Lys Ala Val Ser Thr Ser Gly Arg Ile Leu Val Phe Leu Ser 65 70 75 80 Val Ser Arg Ile Ala Leu Gln Ser Leu Met Met Leu Glu Ile Thr Ile 85 90 95 Ser Ser Thr Ser Leu Ser Phe Tyr Ser Glu Asp Ala Val Tyr Tyr Ala 100 105 110 Phe Lys Ile Ser Phe Ile Phe Leu Asn Phe Cys Ser Leu Trp Phe Ala 115 120 125 Ala Trp Leu Ser Phe Phe Tyr Phe Val Lys Ile Ala Asn Phe Ser Tyr 130 135 140 Pro Leu Phe Leu Lys Leu Arg Trp Arg Ile Thr Gly Leu Ile Pro Trp 145 150 155 160 Leu Leu Trp Leu Ser Val Phe Ile Ser Phe Ser His Ser Met Phe Cys 165 170 175 Ile Asn Ile Cys Thr Val Tyr Cys Asn Asn Ser Phe Pro Ile His Ser 180 185 190 Ser Asn Ser Thr Lys Lys Thr Tyr Leu Ser Glu Ile Asn Val Val Gly 195 200 205 Leu Ala Phe Phe Phe Asn Leu Gly Ile Val Thr Pro Leu Ile Met Phe 210 215 220 Ile Leu Thr Ala Thr Leu Leu Ile Leu Ser Leu Lys Arg His Thr Leu 225 230 235 240 His Met Gly Ser Asn Ala Thr Gly Ser Asn Asp Pro Ser Met Glu Ala 245 250 255 His Ile Gly Ala Ile Lys Ala Ile Ser Tyr Phe Leu Ile Leu Tyr Ile 260 265 270 Phe Asn Ala Ile Ala Leu Phe Leu Ser Thr Ser Asn Ile Phe Asp Thr 275 280 285 Tyr Ser Ser Trp Asn Ile Leu Cys Lys Ile Ile Met Ala Ala Tyr Pro 290 295 300 Ala Gly His Ser Val Gln Leu Ile Leu Gly Asn Pro Gly Leu Arg Arg 305 310 315 320 Ala Trp Lys Arg Phe Gln His Gln Val Pro Leu Tyr Leu Lys Gly Gln 325 330 335 Thr Leu <210> 679 <211> 924 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(924) <400> 679 atg caa gca gca ctg acg gcc ttc ttc gtg ttg ctc ttt agc ctg ctg 48 Met Gln Ala Ala Leu Thr Ala Phe Phe Val Leu Leu Phe Ser Leu Leu 1 5 10 15 agt ctt ctg ggg att gca gcg aat ggc ttc att gtg ctg gtg ctg ggc 96 Ser Leu Leu Gly Ile Ala Ala Asn Gly Phe Ile Val Leu Val Leu Gly 20 25 30 agg gag tgg ctg cga tat ggc agg ttg ctg ccc ttg gat atg atc ctc 144 Arg Glu Trp Leu Arg Tyr Gly Arg Leu Leu Pro Leu Asp Met Ile Leu 35 40 45 att agc ttg ggt gcc tcc cgc ttc tgc ctg cag ttg gtt ggg acg gtg 192 Ile Ser Leu Gly Ala Ser Arg Phe Cys Leu Gln Leu Val Gly Thr Val 50 55 60 cac aac ttc tac tac tct gcc cag aag gtc gag tac tct ggg ggt ctc 240 His Asn Phe Tyr Tyr Ser Ala Gln Lys Val Glu Tyr Ser Gly Gly Leu 65 70 75 80 ggc cga cag ttc ttc cat cta cac tgg cac ttc ctg aac tca gcc acc 288 Gly Arg Gln Phe Phe His Leu His Trp His Phe Leu Asn Ser Ala Thr 85 90 95 ttc tgg ttt tgc agc tgg ctc agt gtc ctg ttc tgt gtg aag att gct 336 Phe Trp Phe Cys Ser Trp Leu Ser Val Leu Phe Cys Val Lys Ile Ala 100 105 110 aac atc aca cac tcc acc ttc ctg tgg ctg aag tgg agg ttc cca ggg 384 Asn Ile Thr His Ser Thr Phe Leu Trp Leu Lys Trp Arg Phe Pro Gly 115 120 125 tgg gtg ccc tgg ctc ctg ttg ggc tct gtc ctg atc tcc ttc atc ata 432 Trp Val Pro Trp Leu Leu Leu Gly Ser Val Leu Ile Ser Phe Ile Ile 130 135 140 acc ctg ctg ttt ttt tgg gtg aac tac cct gta tat caa gaa ttt tta 480 Thr Leu Leu Phe Phe Trp Val Asn Tyr Pro Val Tyr Gln Glu Phe Leu 145 150 155 160 att aga aaa ttt tct ggg aac atg acc tac aag tgg aat aca agg ata 528 Ile Arg Lys Phe Ser Gly Asn Met Thr Tyr Lys Trp Asn Thr Arg Ile 165 170 175 gaa aca tac tat ttc cca tcc ctg aaa ctg gtc atc tgg tca att cct 576 Glu Thr Tyr Tyr Phe Pro Ser Leu Lys Leu Val Ile Trp Ser Ile Pro 180 185 190 ttt tct gtt ttt ctg gtc tca att atg ctg tta att aat tct ctg agg 624 Phe Ser Val Phe Leu Val Ser Ile Met Leu Leu Ile Asn Ser Leu Arg 195 200 205 agg cat act cag aga atg cag cac aac ggg cac agc ctg cag gac ccc 672 Arg His Thr Gln Arg Met Gln His Asn Gly His Ser Leu Gln Asp Pro 210 215 220 agc acc cag gct cac acc aga gct ctg aag tcc ctc atc tcc ttc ctc 720 Ser Thr Gln Ala His Thr Arg Ala Leu Lys Ser Leu Ile Ser Phe Leu 225 230 235 240 att ctt tat gct ctg tcc ttt ctg tcc ctg atc att gat gcc gca aaa 768 Ile Leu Tyr Ala Leu Ser Phe Leu Ser Leu Ile Ile Asp Ala Ala Lys 245 250 255 ttt atc tcc atg cag aac gac ttt tac tgg cca tgg caa att gca gtc 816 Phe Ile Ser Met Gln Asn Asp Phe Tyr Trp Pro Trp Gln Ile Ala Val 260 265 270 tac ctg tgc ata tct gtc cat ccc ttc atc ctc atc ttc agc aac ctc 864 Tyr Leu Cys Ile Ser Val His Pro Phe Ile Leu Ile Phe Ser Asn Leu 275 280 285 aag ctt cga agc gtg ttc tcg cag ctc ctg ttg ttg gca agg ggc ttc 912 Lys Leu Arg Ser Val Phe Ser Gln Leu Leu Leu Leu Ala Arg Gly Phe 290 295 300 tgg gtg gcc tag 924 Trp Val Ala 305 <210> 680 <211> 307 <212> PRT <213> Homo sapiens <400> 680 Met Gln Ala Ala Leu Thr Ala Phe Phe Val Leu Leu Phe Ser Leu Leu 1 5 10 15 Ser Leu Leu Gly Ile Ala Ala Asn Gly Phe Ile Val Leu Val Leu Gly 20 25 30 Arg Glu Trp Leu Arg Tyr Gly Arg Leu Leu Pro Leu Asp Met Ile Leu 35 40 45 Ile Ser Leu Gly Ala Ser Arg Phe Cys Leu Gln Leu Val Gly Thr Val 50 55 60 His Asn Phe Tyr Tyr Ser Ala Gln Lys Val Glu Tyr Ser Gly Gly Leu 65 70 75 80 Gly Arg Gln Phe Phe His Leu His Trp His Phe Leu Asn Ser Ala Thr 85 90 95 Phe Trp Phe Cys Ser Trp Leu Ser Val Leu Phe Cys Val Lys Ile Ala 100 105 110 Asn Ile Thr His Ser Thr Phe Leu Trp Leu Lys Trp Arg Phe Pro Gly 115 120 125 Trp Val Pro Trp Leu Leu Leu Gly Ser Val Leu Ile Ser Phe Ile Ile 130 135 140 Thr Leu Leu Phe Phe Trp Val Asn Tyr Pro Val Tyr Gln Glu Phe Leu 145 150 155 160 Ile Arg Lys Phe Ser Gly Asn Met Thr Tyr Lys Trp Asn Thr Arg Ile 165 170 175 Glu Thr Tyr Tyr Phe Pro Ser Leu Lys Leu Val Ile Trp Ser Ile Pro 180 185 190 Phe Ser Val Phe Leu Val Ser Ile Met Leu Leu Ile Asn Ser Leu Arg 195 200 205 Arg His Thr Gln Arg Met Gln His Asn Gly His Ser Leu Gln Asp Pro 210 215 220 Ser Thr Gln Ala His Thr Arg Ala Leu Lys Ser Leu Ile Ser Phe Leu 225 230 235 240 Ile Leu Tyr Ala Leu Ser Phe Leu Ser Leu Ile Ile Asp Ala Ala Lys 245 250 255 Phe Ile Ser Met Gln Asn Asp Phe Tyr Trp Pro Trp Gln Ile Ala Val 260 265 270 Tyr Leu Cys Ile Ser Val His Pro Phe Ile Leu Ile Phe Ser Asn Leu 275 280 285 Lys Leu Arg Ser Val Phe Ser Gln Leu Leu Leu Leu Ala Arg Gly Phe 290 295 300 Trp Val Ala 305 <210> 681 <211> 930 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(930) <400> 681 atg ata act ttt cta ccc atc att ttt tcc agt ctg gta gtg gtt aca 48 Met Ile Thr Phe Leu Pro Ile Ile Phe Ser Ser Leu Val Val Val Thr 1 5 10 15 ttt gtt att gga aat ttt gct aat ggc ttc ata gca ctg gta aat tcc 96 Phe Val Ile Gly Asn Phe Ala Asn Gly Phe Ile Ala Leu Val Asn Ser 20 25 30 att gag tgg ttc aag aga caa aag atc tcc ttt gct gac caa att ctc 144 Ile Glu Trp Phe Lys Arg Gln Lys Ile Ser Phe Ala Asp Gln Ile Leu 35 40 45 act gct ctg gcg gtc tcc aga gtt ggt ttg ctc tgg gta tta tta tta 192 Thr Ala Leu Ala Val Ser Arg Val Gly Leu Leu Trp Val Leu Leu Leu 50 55 60 aac tgg tat tca act gtg ttg aat cca gct ttt aat agt gta gaa gta 240 Asn Trp Tyr Ser Thr Val Leu Asn Pro Ala Phe Asn Ser Val Glu Val 65 70 75 80 aga act act gct tat aat atc tgg gca gtg atc aac cat ttc agc aac 288 Arg Thr Thr Ala Tyr Asn Ile Trp Ala Val Ile Asn His Phe Ser Asn 85 90 95 tgg ctt gct act acc ctc agc ata ttt tat ttg ctc aag att gcc aat 336 Trp Leu Ala Thr Thr Leu Ser Ile Phe Tyr Leu Leu Lys Ile Ala Asn 100 105 110 ttc tcc aac ttt att ttt ctt cac tta aag agg aga gtt aag agt gtc 384 Phe Ser Asn Phe Ile Phe Leu His Leu Lys Arg Arg Val Lys Ser Val 115 120 125 att ctg gtg atg ttg ttg ggg cct ttg cta ttt ttg gct tgt cat ctt 432 Ile Leu Val Met Leu Leu Gly Pro Leu Leu Phe Leu Ala Cys His Leu 130 135 140 ttt gtg ata aac atg aat gag att gtg cgg aca aaa gaa ttt gaa gga 480 Phe Val Ile Asn Met Asn Glu Ile Val Arg Thr Lys Glu Phe Glu Gly 145 150 155 160 aac atg act tgg aag atc aaa ttg aag agt gca atg tac ttt tca aat 528 Asn Met Thr Trp Lys Ile Lys Leu Lys Ser Ala Met Tyr Phe Ser Asn 165 170 175 atg act gta acc atg gta gca aac tta gta ccc ttc act ctg acc cta 576 Met Thr Val Thr Met Val Ala Asn Leu Val Pro Phe Thr Leu Thr Leu 180 185 190 cta tct ttt atg ctg tta atc tgt tct ttg tgt aaa cat ctc aag aag 624 Leu Ser Phe Met Leu Leu Ile Cys Ser Leu Cys Lys His Leu Lys Lys 195 200 205 atg cag ctc cat ggt aaa gga tct caa gat ccc agc acc aag gtc cac 672 Met Gln Leu His Gly Lys Gly Ser Gln Asp Pro Ser Thr Lys Val His 210 215 220 ata aaa gct ttg caa act gtg atc tcc ttc ctc ttg tta tgt gcc att 720 Ile Lys Ala Leu Gln Thr Val Ile Ser Phe Leu Leu Leu Cys Ala Ile 225 230 235 240 tac ttt ctg tcc ata atg ata tca gtt tgg agt ttt gga agt ctg gaa 768 Tyr Phe Leu Ser Ile Met Ile Ser Val Trp Ser Phe Gly Ser Leu Glu 245 250 255 aac aaa cct gtc ttc atg ttc tgc aaa gct att aga ttc agc tat cct 816 Asn Lys Pro Val Phe Met Phe Cys Lys Ala Ile Arg Phe Ser Tyr Pro 260 265 270 tca atc cac cca ttc atc ctg att tgg gga aac aag aag cta aag cag 864 Ser Ile His Pro Phe Ile Leu Ile Trp Gly Asn Lys Lys Leu Lys Gln 275 280 285 act ttt ctt tca gtt ttt tgg caa atg agg tac tgg gtg aaa gga gag 912 Thr Phe Leu Ser Val Phe Trp Gln Met Arg Tyr Trp Val Lys Gly Glu 290 295 300 aag act tca tct cca tag 930 Lys Thr Ser Ser Pro 305 310 <210> 682 <211> 309 <212> PRT <213> Homo sapiens <400> 682 Met Ile Thr Phe Leu Pro Ile Ile Phe Ser Ser Leu Val Val Val Thr 1 5 10 15 Phe Val Ile Gly Asn Phe Ala Asn Gly Phe Ile Ala Leu Val Asn Ser 20 25 30 Ile Glu Trp Phe Lys Arg Gln Lys Ile Ser Phe Ala Asp Gln Ile Leu 35 40 45 Thr Ala Leu Ala Val Ser Arg Val Gly Leu Leu Trp Val Leu Leu Leu 50 55 60 Asn Trp Tyr Ser Thr Val Leu Asn Pro Ala Phe Asn Ser Val Glu Val 65 70 75 80 Arg Thr Thr Ala Tyr Asn Ile Trp Ala Val Ile Asn His Phe Ser Asn 85 90 95 Trp Leu Ala Thr Thr Leu Ser Ile Phe Tyr Leu Leu Lys Ile Ala Asn 100 105 110 Phe Ser Asn Phe Ile Phe Leu His Leu Lys Arg Arg Val Lys Ser Val 115 120 125 Ile Leu Val Met Leu Leu Gly Pro Leu Leu Phe Leu Ala Cys His Leu 130 135 140 Phe Val Ile Asn Met Asn Glu Ile Val Arg Thr Lys Glu Phe Glu Gly 145 150 155 160 Asn Met Thr Trp Lys Ile Lys Leu Lys Ser Ala Met Tyr Phe Ser Asn 165 170 175 Met Thr Val Thr Met Val Ala Asn Leu Val Pro Phe Thr Leu Thr Leu 180 185 190 Leu Ser Phe Met Leu Leu Ile Cys Ser Leu Cys Lys His Leu Lys Lys 195 200 205 Met Gln Leu His Gly Lys Gly Ser Gln Asp Pro Ser Thr Lys Val His 210 215 220 Ile Lys Ala Leu Gln Thr Val Ile Ser Phe Leu Leu Leu Cys Ala Ile 225 230 235 240 Tyr Phe Leu Ser Ile Met Ile Ser Val Trp Ser Phe Gly Ser Leu Glu 245 250 255 Asn Lys Pro Val Phe Met Phe Cys Lys Ala Ile Arg Phe Ser Tyr Pro 260 265 270 Ser Ile His Pro Phe Ile Leu Ile Trp Gly Asn Lys Lys Leu Lys Gln 275 280 285 Thr Phe Leu Ser Val Phe Trp Gln Met Arg Tyr Trp Val Lys Gly Glu 290 295 300 Lys Thr Ser Ser Pro 305 <210> 683 <211> 759 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(759) <400> 683 atg gta tat ttt ctg ctc atc att tta tca att ctg gta gtg ttt gca 48 Met Val Tyr Phe Leu Leu Ile Ile Leu Ser Ile Leu Val Val Phe Ala 1 5 10 15 ttt gtt ctt gga aat ttt tcc aat ggc ttc ata gct cta gta aat gtc 96 Phe Val Leu Gly Asn Phe Ser Asn Gly Phe Ile Ala Leu Val Asn Val 20 25 30 att gac tgg gtt aag aca cga aag atc tcc tca gct gac caa atc ctc 144 Ile Asp Trp Val Lys Thr Arg Lys Ile Ser Ser Ala Asp Gln Ile Leu 35 40 45 act gct ctg gtg gtc tcc aga att ggt tta ctc tgg gtc ata tta tta 192 Thr Ala Leu Val Val Ser Arg Ile Gly Leu Leu Trp Val Ile Leu Leu 50 55 60 cat tgg tat gca aat gtg ttt aat tca gct tta tat agt tca gaa gta 240 His Trp Tyr Ala Asn Val Phe Asn Ser Ala Leu Tyr Ser Ser Glu Val 65 70 75 80 gga gct gtt gct tct aat atc tca gca ata atc aac cat ttc agc atc 288 Gly Ala Val Ala Ser Asn Ile Ser Ala Ile Ile Asn His Phe Ser Ile 85 90 95 tgg ctt gct gct agc ctc agc ata ttt tat ttg ctc aag att gcc aat 336 Trp Leu Ala Ala Ser Leu Ser Ile Phe Tyr Leu Leu Lys Ile Ala Asn 100 105 110 ttc tcc aac ctt att ttt ctc cac cta aag aag aga att agg agt gtt 384 Phe Ser Asn Leu Ile Phe Leu His Leu Lys Lys Arg Ile Arg Ser Val 115 120 125 gtt ctg gtg ata ctg ttg ggt ccc ttg gta ttt ttg att tgt aat ctt 432 Val Leu Val Ile Leu Leu Gly Pro Leu Val Phe Leu Ile Cys Asn Leu 130 135 140 gct gtg ata acc atg gat gac agt gtg tgg aca aaa gaa tat gaa gga 480 Ala Val Ile Thr Met Asp Asp Ser Val Trp Thr Lys Glu Tyr Glu Gly 145 150 155 160 aat gtg act tgg aag atc aaa ttg agg aat gca ata cac ctt tca aac 528 Asn Val Thr Trp Lys Ile Lys Leu Arg Asn Ala Ile His Leu Ser Asn 165 170 175 ttg act gta agc aca cta gca aac ctc ata ccc ttc att ctg acc cta 576 Leu Thr Val Ser Thr Leu Ala Asn Leu Ile Pro Phe Ile Leu Thr Leu 180 185 190 ata tgt ttt ctg ctg tta atc tgt tct ctg cat aaa cat ctc aag aag 624 Ile Cys Phe Leu Leu Leu Ile Cys Ser Leu His Lys His Leu Lys Lys 195 200 205 atg cag ctc cat ggc aaa gga tct caa gat ctc agc acc aag gtc cac 672 Met Gln Leu His Gly Lys Gly Ser Gln Asp Leu Ser Thr Lys Val His 210 215 220 ata aaa gct ttg caa act gtg atc tcc ttc ctc atg tta tat gcc att 720 Ile Lys Ala Leu Gln Thr Val Ile Ser Phe Leu Met Leu Tyr Ala Ile 225 230 235 240 tac ttt ctg tat cta atc aca tta acc tgg aat ctt tga 759 Tyr Phe Leu Tyr Leu Ile Thr Leu Thr Trp Asn Leu 245 250 <210> 684 <211> 252 <212> PRT <213> Homo sapiens <400> 684 Met Val Tyr Phe Leu Leu Ile Ile Leu Ser Ile Leu Val Val Phe Ala 1 5 10 15 Phe Val Leu Gly Asn Phe Ser Asn Gly Phe Ile Ala Leu Val Asn Val 20 25 30 Ile Asp Trp Val Lys Thr Arg Lys Ile Ser Ser Ala Asp Gln Ile Leu 35 40 45 Thr Ala Leu Val Val Ser Arg Ile Gly Leu Leu Trp Val Ile Leu Leu 50 55 60 His Trp Tyr Ala Asn Val Phe Asn Ser Ala Leu Tyr Ser Ser Glu Val 65 70 75 80 Gly Ala Val Ala Ser Asn Ile Ser Ala Ile Ile Asn His Phe Ser Ile 85 90 95 Trp Leu Ala Ala Ser Leu Ser Ile Phe Tyr Leu Leu Lys Ile Ala Asn 100 105 110 Phe Ser Asn Leu Ile Phe Leu His Leu Lys Lys Arg Ile Arg Ser Val 115 120 125 Val Leu Val Ile Leu Leu Gly Pro Leu Val Phe Leu Ile Cys Asn Leu 130 135 140 Ala Val Ile Thr Met Asp Asp Ser Val Trp Thr Lys Glu Tyr Glu Gly 145 150 155 160 Asn Val Thr Trp Lys Ile Lys Leu Arg Asn Ala Ile His Leu Ser Asn 165 170 175 Leu Thr Val Ser Thr Leu Ala Asn Leu Ile Pro Phe Ile Leu Thr Leu 180 185 190 Ile Cys Phe Leu Leu Leu Ile Cys Ser Leu His Lys His Leu Lys Lys 195 200 205 Met Gln Leu His Gly Lys Gly Ser Gln Asp Leu Ser Thr Lys Val His 210 215 220 Ile Lys Ala Leu Gln Thr Val Ile Ser Phe Leu Met Leu Tyr Ala Ile 225 230 235 240 Tyr Phe Leu Tyr Leu Ile Thr Leu Thr Trp Asn Leu 245 250 <210> 685 <211> 957 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(957) <400> 685 atg tta aag gac tca gaa caa gtg tta cta agc ctg cat ttt ttt atc 48 Met Leu Lys Asp Ser Glu Gln Val Leu Leu Ser Leu His Phe Phe Ile 1 5 10 15 tgt tca aac atg atg tgt ttt ctg ctc atc att tca tca att ctg gta 96 Cys Ser Asn Met Met Cys Phe Leu Leu Ile Ile Ser Ser Ile Leu Val 20 25 30 gtg ttt gca ttt gtt ctt gga aat gtt gcc aat ggc ttc ata gcc cta 144 Val Phe Ala Phe Val Leu Gly Asn Val Ala Asn Gly Phe Ile Ala Leu 35 40 45 gta aat gtc att gac tgg gtt aac aca cga aag atc tcc tca gct gag 192 Val Asn Val Ile Asp Trp Val Asn Thr Arg Lys Ile Ser Ser Ala Glu 50 55 60 caa att ctc act gct ctg gtg gtc tcc aga att ggt tta ctc tgg gtc 240 Gln Ile Leu Thr Ala Leu Val Val Ser Arg Ile Gly Leu Leu Trp Val 65 70 75 80 atg tta ttc ctt tgg tat gca act gtg ttt aat tct gct tta tat ggt 288 Met Leu Phe Leu Trp Tyr Ala Thr Val Phe Asn Ser Ala Leu Tyr Gly 85 90 95 tta gaa gta aga att gtt gct tct aat gcc tgg gct gta acg aac cat 336 Leu Glu Val Arg Ile Val Ala Ser Asn Ala Trp Ala Val Thr Asn His 100 105 110 ttc agc atg tgg ctt gct gct agc ctc agc ata ttt tgt ttg ctc aag 384 Phe Ser Met Trp Leu Ala Ala Ser Leu Ser Ile Phe Cys Leu Leu Lys 115 120 125 att gcc aat ttc tcc aac ctt att tct ctc cac cta aag aag aga att 432 Ile Ala Asn Phe Ser Asn Leu Ile Ser Leu His Leu Lys Lys Arg Ile 130 135 140 aag agt gtt gtt ctg gtg ata ctg ttg ggg ccc ttg gta ttt ctg att 480 Lys Ser Val Val Leu Val Ile Leu Leu Gly Pro Leu Val Phe Leu Ile 145 150 155 160 tgt aat ctt gct gtg ata acc atg gat gag aga gtg tgg aca aaa gaa 528 Cys Asn Leu Ala Val Ile Thr Met Asp Glu Arg Val Trp Thr Lys Glu 165 170 175 tat gaa gga aat gtg act tgg aag atc aaa ttg agg aat gca ata cac 576 Tyr Glu Gly Asn Val Thr Trp Lys Ile Lys Leu Arg Asn Ala Ile His 180 185 190 ctt tca agc ttg act gta act act cta gca aac ctc ata ccc ttt act 624 Leu Ser Ser Leu Thr Val Thr Thr Leu Ala Asn Leu Ile Pro Phe Thr 195 200 205 ctg agc cta ata tgt ttt ctg ctg tta atc tgt tct ctt tgt aaa cat 672 Leu Ser Leu Ile Cys Phe Leu Leu Leu Ile Cys Ser Leu Cys Lys His 210 215 220 ctc aag aag atg cgg ctc cat agc aaa gga tct caa gat ccc agc acc 720 Leu Lys Lys Met Arg Leu His Ser Lys Gly Ser Gln Asp Pro Ser Thr 225 230 235 240 aag gtc cat ata aaa gct ttg caa act gtg acc tcc ttc ctc atg tta 768 Lys Val His Ile Lys Ala Leu Gln Thr Val Thr Ser Phe Leu Met Leu 245 250 255 ttt gcc att tac ttt ctg tgt ata atc aca tca act tgg aat ctt agg 816 Phe Ala Ile Tyr Phe Leu Cys Ile Ile Thr Ser Thr Trp Asn Leu Arg 260 265 270 aca cag cag agc aaa ctt gta ctc ctg ctt tgc caa act gtt gca atc 864 Th r Gln Gln Ser Lys Leu Val Leu Leu Leu Cys Gln Thr Val Ala Ile 275 280 285 atg tat cct tca ttc cac tca ttc atc ctg att atg gga agt agg aag 912 Met Tyr Pro Ser Phe His Ser Phe Ile Leu Ile Met Gly Ser Arg Lys 290 295 300 cta aaa cag acc ttt ctt tca gtt ttg tgg cag atg aca cgc tga 957 Leu Lys Gln Thr Phe Leu Ser Val Leu Trp Gln Met Thr Arg 305 310 315 <210> 686 <211> 318 <212> PRT <213> Homo sapiens <400> 686 Met Leu Lys Asp Ser Glu Gln Val Leu Leu Ser Leu His Phe Phe Ile 1 5 10 15 Cys Ser Asn Met Met Cys Phe Leu Leu Ile Ile Ser Ser Ile Leu Val 20 25 30 Val Phe Ala Phe Val Leu Gly Asn Val Ala Asn Gly Phe Ile Ala Leu 35 40 45 Val Asn Val Ile Asp Trp Val Asn Thr Arg Lys Ile Ser Ser Ala Glu 50 55 60 Gln Ile Leu Thr Ala Leu Val Val Ser Arg Ile Gly Leu Leu Trp Val 65 70 75 80 Met Leu Phe Leu Trp Tyr Ala Thr Val Phe Asn Ser Ala Leu Tyr Gly 85 90 95 Leu Glu Val Arg Ile Val Ala Ser Asn Ala Trp Ala Val Thr Asn His 100 105 110 Phe Ser Met Trp Leu Ala Ala Ser Leu Ser Ile Phe Cys Leu Leu Lys 115 120 125 Ile Ala Asn Phe Ser Asn Leu Ile Ser Leu His Leu Lys Lys Arg Ile 130 135 140 Lys Ser Val Val Leu Val Ile Leu Leu Gly Pro Leu Val Phe Leu Ile 145 150 155 160 Cys Asn Leu Ala Val Ile Thr Met Asp Glu Arg Val Trp Thr Lys Glu 165 170 175 Tyr Glu Gly Asn Val Thr Trp Lys Ile Lys Leu Arg Asn Ala Ile His 180 185 190 Leu Ser Ser Leu Thr Val Thr Thr Leu Ala Asn Leu Ile Pro Phe Thr 195 200 205 Leu Ser Leu Ile Cys Phe Leu Leu Leu Ile Cys Ser Leu Cys Lys His 210 215 220 Leu Lys Lys Met Arg Leu His Ser Lys Gly Ser Gln Asp Pro Ser Thr 225 230 235 240 Lys Val His Ile Lys Ala Leu Gln Thr Val Thr Ser Phe Leu Met Leu 245 250 255 Phe Ala Ile Tyr Phe Leu Cys Ile Ile Thr Ser Thr Trp Asn Leu Arg 260 265 270 Thr Gln Gln Ser Lys Leu Val Leu Leu Leu Cys Gln Thr Val Ala Ile 275 280 285 Met Tyr Pro Ser Phe His Ser Phe Ile Leu Ile Met Gly Ser Arg Lys 290 295 300 Leu Lys Gln Thr Phe Leu Ser Val Leu Trp Gln Met Thr Arg 305 310 315 <210> 687 <211> 930 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(930) <400> 687 atg atg agt ttt cta cac att gtt ttt tcc att cta gta gtg gtt gca 48 Met Met Ser Phe Leu His Ile Val Phe Ser Ile Leu Val Val Val Ala 1 5 10 15 ttt att ctt gga aat ttt gcc aat ggc ttt ata gca ctg ata aat ttc 96 Phe Ile Leu Gly Asn Phe Ala Asn Gly Phe Ile Ala Leu Ile Asn Phe 20 25 30 att gcc tgg gtc aag aga caa aag atc tcc tca gct gat caa att att 144 Ile Ala Trp Val Lys Arg Gln Lys Ile Ser Ser Ala Asp Gln Ile Ile 35 40 45 gct gct ctg gca gtc tcc aga gtt ggt ttg ctc tgg gta ata tta tta 192 Ala Ala Leu Ala Val Ser Arg Val Gly Leu Leu Trp Val Ile Leu Leu 50 55 60 cat tgg tat tca act gtg ttg aat cca act tca tct aat tta aaa gta 240 His Trp Tyr Ser Thr Val Leu Asn Pro Thr Ser Ser Asn Leu Lys Val 65 70 75 80 ata att ttt att tct aat gcc tgg gca gta acc aat cat ttc agc atc 288 Ile Ile Phe Ile Ser Asn Ala Trp Ala Val Thr Asn His Phe Ser Ile 85 90 95 tgg ctt gct act agc ctc agc ata ttt tat ttg ctc aag atc gtc aat 336 Trp Leu Ala Thr Ser Leu Ser Ile Phe Tyr Leu Leu Lys Ile Val Asn 100 105 110 ttc tcc aga ctt att ttt cat cac tta aaa agg aag gct aag agt gta 384 Phe Ser Arg Leu Ile Phe His His Leu Lys Arg Lys Ala Lys Ser Val 115 120 125 gtt ctg gtg ata gtg ttg ggg tct ttg ttc ttt ttg gtt tgt cac ctt 432 Val Leu Val Ile Val Leu Gly Ser Leu Phe Phe Leu Val Cys His Leu 130 135 140 gtg atg aaa cac acg tat ata aat gtg tgg aca gaa gaa tgt gaa gga 480 Val Met Lys His Thr Tyr Ile Asn Val Trp Thr Glu Glu Cys Glu Gly 145 150 155 160 aac gta act tgg aag atc aaa ctg agg aat gca atg cac ctt tcc aac 528 Asn Val Thr Trp Lys Ile Lys Leu Arg Asn Ala Met His Leu Ser Asn 165 170 175 ttg act gta gcc atg cta gca aac ttg ata cca ttc act ctg acc ctg 576 Leu Thr Val Ala Met Leu Ala Asn Leu Ile Pro Phe Thr Leu Thr Leu 180 185 190 ata tct ttt ctg ctg tta atc tac tct ctg tgt aaa cat ctg aag aag 624 Ile Ser Phe Leu Leu Leu Ile Tyr Ser Leu Cys Lys His Leu Lys Lys 195 200 205 atg cag ctc cat ggc aaa gga tct caa gat ccc agc acc aag atc cac 672 Met Gln Leu His Gly Lys Gly Ser Gln Asp Pro Ser Thr Lys Ile His 210 215 220 ata aaa gct ctg caa act gtg acc tcc ttc ctc ata tta ctt gcc att 720 Ile Lys Ala Leu Gln Thr Val Thr Ser Phe Leu Ile Leu Leu Ala Ile 225 230 235 240 tac ttt ctg tgt cta atc ata tcg ttt tgg aat ttt aag atg cga cca 768 Tyr Phe Leu Cys Leu Ile Ile Ser Phe Trp Asn Phe Lys Met Arg Pro 245 250 255 aaa gaa att gtc tta atg ctt tgc caa gct ttt gga atc ata tat cca 816 Lys Glu Ile Val Leu Met Leu Cys Gln Ala Phe Gly Ile Ile Tyr Pro 260 265 270 tca ttc cac tca ttc att ctg att tgg ggg aac aag acg cta aag cag 864 Ser Phe His Ser Phe Ile Leu Ile Trp Gly Asn Lys Thr Leu Lys Gln 275 280 285 acc ttt ctt tca gtt ttg tgg cag gtg act tgc tgg gca aaa gga cag 912 Thr Phe Leu Ser Val Leu Trp Gln Val Thr Cys Trp Ala Lys Gly Gln 290 295 300 aac cag tca act cca tag 930 Asn Gln Ser Thr Pro 305 310 <210> 688 <211> 309 <212> PRT <213> Homo sapiens <400> 688 Met Met Ser Phe Leu His Ile Val Phe Ser Ile Leu Val Val Val Ala 1 5 10 15 Phe Ile Leu Gly Asn Phe Ala Asn Gly Phe Ile Ala Leu Ile Asn Phe 20 25 30 Ile Ala Trp Val Lys Arg Gln Lys Ile Ser Ser Ala Asp Gln Ile Ile 35 40 45 Ala Ala Leu Ala Val Ser Arg Val Gly Leu Leu Trp Val Ile Leu Leu 50 55 60 His Trp Tyr Ser Thr Val Leu Asn Pro Thr Ser Ser Asn Leu Lys Val 65 70 75 80 Ile Ile Phe Ile Ser Asn Ala Trp Ala Val Thr Asn His Phe Ser Ile 85 90 95 Trp Leu Ala Thr Ser Leu Ser Ile Phe Tyr Leu Leu Lys Ile Val Asn 100 105 110 Phe Ser Arg Leu Ile Phe His His Leu Lys Arg Lys Ala Lys Ser Val 115 120 125 Val Leu Val Ile Val Leu Gly Ser Leu Phe Phe Leu Val Cys His Leu 130 135 140 Val Met Lys His Thr Tyr Ile Asn Val Trp Thr Glu Glu Cys Glu Gly 145 150 155 160 Asn Val Thr Trp Lys Ile Lys Leu Arg Asn Ala Met His Leu Ser Asn 165 170 175 Leu Thr Val Ala Met Leu Ala Asn Leu Ile Pro Phe Thr Leu Thr Leu 180 185 190 Ile Ser Phe Leu Leu Leu Ile Tyr Ser Leu Cys Lys His Leu Lys Lys 195 200 205 Met Gln Leu His Gly Lys Gly Ser Gln Asp Pro Ser Thr Lys Ile His 210 215 220 Ile Lys Ala Leu Gln Thr Val Thr Ser Phe Leu Ile Leu Leu Ala Ile 225 230 235 240 Tyr Phe Leu Cys Leu Ile Ile Ser Phe Trp Asn Phe Lys Met Arg Pro 245 250 255 L ys Glu Ile Val Leu Met Leu Cys Gln Ala Phe Gly Ile Ile Tyr Pro 260 265 270 Ser Phe His Ser Phe Ile Leu Ile Trp Gly Asn Lys Thr Leu Lys Gln 275 280 285 Thr Phe Leu Ser Val Leu Trp Gln Val Thr Cys Trp Ala Lys Gly Gln 290 295 300 Asn Gln Ser Thr Pro 305 <210> 689 <211> 771 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(771) <400> 689 atg ata act ttt cta ccc atc att ttt tcc att cta gta gtg gtt aca 48 Met Ile Thr Phe Leu Pro Ile Ile Phe Ser Ile Leu Val Val Val Thr 1 5 10 15 ttt gtt ctt ggg aat ttt gct aat ggc ttc ata gtg ttg gta aat tcc 96 Phe Val Leu Gly Asn Phe Ala Asn Gly Phe Ile Val Leu Val Asn Ser 20 25 30 att gag tgg gtc aag aga caa aag atc tcc ttt gct gac caa att ctc 144 Ile Glu Trp Val Lys Arg Gln Lys Ile Ser Phe Ala Asp Gln Ile Leu 35 40 45 act gct ctg gca gtc tcc aga gtt ggt ttg ctc tgg gta ata tta tta 192 Thr Ala Leu Ala Val Ser Arg Val Gly Leu Leu Trp Val Ile Leu Leu 50 55 60 cat tgg tat gca act gtt ttg aat cca ggt tca tat agt tta gga gta 240 His Trp Tyr Ala Thr Val Leu Asn Pro Gly Ser Tyr Ser Leu Gly Val 65 70 75 80 aga att act act att aat gcc tgg gct gta acc aac cat ttc agc atc 288 Arg Ile Thr Thr Ile Asn Ala Trp Ala Val Thr Asn His Phe Ser Ile 85 90 95 tgg gtt gct act agc ctc agc ata ttt tat ttc ctc aag att gcc aat 336 Trp Val Ala Thr Ser Leu Ser Ile Phe Tyr Phe Leu Lys Ile Ala Asn 100 105 110 ttc tcc aac ttt att ttt ctt cac tta aaa agg aga att aag agt gtc 384 Phe Ser Asn Phe Ile Phe Leu His Leu Lys Arg Arg Ile Lys Ser Val 115 120 125 att cca gtg ata cta ttg ggg tct ttg tta ttt ttg gtt tgt cat ctt 432 Ile Pro Val Ile Leu Leu Gly Ser Leu Leu Phe Leu Val Cys His Leu 130 135 140 gtt gtg gta aac atg gat gag agt atg tgg aca aaa gaa tat gaa gga 480 Val Val Val Asn Met Asp Glu Ser Met Trp Thr Lys Glu Tyr Glu Gly 145 150 155 160 aac gtg agt tgg gag atc aaa ttg agt gat ccg acg cac ctt tca gat 528 Asn Val Ser Trp Glu Ile Lys Leu Ser Asp Pro Thr His Leu Ser Asp 165 170 175 atg act gta acc acg ctt gca aac tta ata ccc ttt act ctg tcc ctg 576 Met Thr Val Thr Thr Leu Ala Asn Leu Ile Pro Phe Thr Leu Ser Leu 180 185 190 tta tct ttt ctg ctc tta atc tgt tct ttg tgt aaa cat ctc aag aag 624 Leu Ser Phe Leu Leu Leu Ile Cys Ser Leu Cys Lys His Leu Lys Lys 195 200 205 atg cag ttc cat ggc aaa gga tct cca gat tcc aac acc aag gtc cac 672 Met Gln Phe His Gly Lys Gly Ser Pro Asp Ser Asn Thr Lys Val His 210 215 220 ata aaa gct ttg caa acg gtg acc tcc ttc ctc ttg tta ttt gct gtt 720 Ile Lys Ala Leu Gln Thr Val Thr Ser Phe Leu Leu Leu Phe Ala Val 225 230 235 240 tac ttt ctg tcc cta atc aca tcg att tgg aat ttt agg agg agg ctg 768 Tyr Phe Leu Ser Leu Ile Thr Ser Ile Trp Asn Phe Arg Arg Arg Leu 245 250 255 tag 771 <210> 690 <211> 256 <212> PRT <213> Homo sapiens <400> 690 Met Ile Thr Phe Leu Pro Ile Ile Phe Ser Ile Leu Val Val Val Thr 1 5 10 15 Phe Val Leu Gly Asn Phe Ala Asn Gly Phe Ile Val Leu Val Asn Ser 20 25 30 Ile Glu Trp Val Lys Arg Gln Lys Ile Ser Phe Ala Asp Gln Ile Leu 35 40 45 Thr Ala Leu Ala Val Ser Arg Val Gly Leu Leu Trp Val Ile Leu Leu 50 55 60 His Trp Tyr Ala Thr Val Leu Asn Pro Gly Ser Tyr Ser Leu Gly Val 65 70 75 80 Arg Ile Thr Thr Ile Asn Ala Trp Ala Val Thr Asn His Phe Ser Ile 85 90 95 Trp Val Ala Thr Ser Leu Ser Ile Phe Tyr Phe Leu Lys Ile Ala Asn 100 105 110 Phe Ser Asn Phe Ile Phe Leu His Leu Lys Arg Arg Ile Lys Ser Val 115 120 125 Ile Pro Val Ile Leu Leu Gly Ser Leu Leu Phe Leu Val Cys His Leu 130 135 140 Val Val Val Asn Met Asp Glu Ser Met Trp Thr Lys Glu Tyr Glu Gly 145 150 155 160 Asn Val Ser Trp Glu Ile Lys Leu Ser Asp Pro Thr His Leu Ser Asp 165 170 175 Met Thr Val Thr Thr Leu Ala Asn Leu Ile Pro Phe Thr Leu Ser Leu 180 185 190 Leu Ser Phe Leu Leu Leu Ile Cys Ser Leu Cys Lys His Leu Lys Lys 195 200 205 Met Gln Phe His Gly Lys Gly Ser Pro Asp Ser Asn Thr Lys Val His 210 215 220 Ile Lys Ala Leu Gln Thr Val Thr Ser Phe Leu Leu Leu Phe Ala Val 225 230 235 240 Tyr Phe Leu Ser Leu Ile Thr Ser Ile Trp Asn Phe Arg Arg Arg Leu 245 250 255 <210> 691 <211> 930 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(930) <400> 691 atg aca act ttt ata ccc atc att ttt tcc agt gtg gta gtg gtt cta 48 Met Thr Thr Phe Ile Pro Ile Ile Phe Ser Ser Val Val Val Val Leu 1 5 10 15 ttt gtt att gga aat ttt gct aat ggc ttc ata gca ttg gta aat tcc 96 Phe Val Ile Gly Asn Phe Ala Asn Gly Phe Ile Ala Leu Val Asn Ser 20 25 30 att gag cgg gtc aag aga caa aag atc tct ttt gct gac cag att ctc 144 Ile Glu Arg Val Lys Arg Gln Lys Ile Ser Phe Ala Asp Gln Ile Leu 35 40 45 act gct ctg gcg gtc tcc aga gtt ggt ttg ctc tgg gta tta tta tta 192 Thr Ala Leu Ala Val Ser Arg Val Gly Leu Leu Trp Val Leu Leu Leu 50 55 60 aat tgg tat tca act gtg ttt aat cca gct ttt tat agt gta gaa gta 240 Asn Trp Tyr Ser Thr Val Phe Asn Pro Ala Phe Tyr Ser Val Glu Val 65 70 75 80 aga act act gct tat aat gtc tgg gca gta acc ggc cat ttc agc aac 288 Arg Thr Thr Ala Tyr Asn Val Trp Ala Val Thr Gly His Phe Ser Asn 85 90 95 tgg ctt gct act agc ctc agc ata ttt tat ttg ctc aag att gcc aat 336 Trp Leu Ala Thr Ser Leu Ser Ile Phe Tyr Leu Leu Lys Ile Ala Asn 100 105 110 ttc tcc aac ctt att ttt ctt cac tta aag agg aga gtt aag agt gtc 384 Phe Ser Asn Leu Ile Phe Leu His Leu Lys Arg Arg Val Lys Ser Val 115 120 125 att ctg gtg atg ctg ttg ggg cct tta cta ttt ttg gct tgt caa ctt 432 Ile Leu Val Met Leu Leu Gly Pro Leu Leu Phe Leu Ala Cys Gln Leu 130 135 140 ttt gtg ata aac atg aaa gag att gta cgg aca aaa gaa tat gaa gga 480 Phe Val Ile Asn Met Lys Glu Ile Val Arg Thr Lys Glu Tyr Glu Gly 145 150 155 160 aac ttg act tgg aag atc aaa ttg agg agt gca gtg tac ctt tca gat 528 Asn Leu Thr Trp Lys Ile Lys Leu Arg Ser Ala Val Tyr Leu Ser Asp 165 170 175 gcg act gta acc acg cta gga aac tta gtg ccc ttc act ctg acc ctg 576 Ala Thr Val Thr Thr Leu Gly Asn Leu Val Pro Phe Thr Leu Thr Leu 180 185 190 cta tgt ttt ttg ctg tta atc tgt tct ctg tgt aaa cat ctc aag aag 624 Leu Cys Phe Leu Leu Leu Ile Cys Ser Leu Cys Lys His Leu Lys Lys 195 200 205 atg cag ctc cat ggt aaa gga tct caa gat ccc agc acc aag gtc cac 672 Met Gln Leu His Gly Lys Gly Ser Gln Asp Pro Ser Thr Lys Val His 210 215 220 ata aaa gct ttg caa act gtg atc ttt ttc ctc ttg tta tgt gcc gtt 720 Ile Lys Ala Leu Gln Thr Val Ile Phe Phe Leu Leu Leu Cys Ala Val 225 230 235 240 tac ttt ctg tcc ata atg ata tca gtt tgg agt ttt ggg agt ctg gaa 768 Tyr Phe Leu Ser Ile Met Ile Ser Val Trp Ser Phe Gly Ser Leu Glu 245 250 255 aac aaa cct gtc ttc atg ttc tgc aaa gct att aga ttc agc tat cct 816 Asn Lys Pro Val Phe Met Phe Cys Lys Ala Ile Arg Phe Ser Tyr Pro 260 265 270 tca atc cac cca ttc atc ctg att tgg gga aac aag aag cta aag cag 864 Ser Ile His Pro Phe Ile Leu Ile Trp Gly Asn Lys Lys Leu Lys Gln 275 280 285 act ttt ctt tca gtt ttg cgg caa gtg agg tac tgg gtg aaa gga gag 912 Thr Phe Leu Ser Val Leu Arg Gln Val Arg Tyr Trp Val Lys Gly Glu 290 295 300 aag cct tca tct cca tag 930 Lys Pro Ser Ser Pro 305 310 <210> 692 <211> 309 <212> PRT <213> Homo sapiens <400> 692 Met Thr Thr Phe Ile Pro Ile Ile Phe Ser Ser Val Val Val Val Leu 1 5 10 15 Phe Val Ile Gly Asn Phe Ala Asn Gly Phe Ile Ala Leu Val Asn Ser 20 25 30 Ile Glu Arg Val Lys Arg Gln Lys Ile Ser Phe Ala Asp Gln Ile Leu 35 40 45 Thr Ala Leu Ala Val Ser Arg Val Gly Leu Leu Trp Val Leu Leu Leu 50 55 60 Asn Trp Tyr Ser Thr Val Phe Asn Pro Ala Phe Tyr Ser Val Glu Val 65 70 75 80 Arg Thr Thr Ala Tyr Asn Val Trp Ala Val Thr Gly His Phe Ser Asn 85 90 95 Trp Leu Ala Thr Ser Leu Ser Ile Phe Tyr Leu Leu Lys Ile Ala Asn 100 105 110 Phe Ser Asn Leu Ile Phe Leu His Leu Lys Arg Arg Val Lys Ser Val 115 120 125 Ile Leu Val Met Leu Leu Gly Pro Leu Leu Phe Leu Ala Cys Gln Leu 130 135 140 Phe Val Ile Asn Met Lys Glu Ile Val Arg Thr Lys Glu Tyr Glu Gly 145 150 155 160 Asn Leu Thr Trp Lys Ile Lys Leu Arg Ser Ala Val Tyr Leu Ser Asp 165 170 175 Ala Thr Val Thr Thr Leu Gly Asn Leu Val Pro Phe Thr Leu Thr Leu 180 185 190 Leu Cys Phe Leu Leu Leu Ile Cys Ser Leu Cys Lys His Leu Lys Lys 195 200 205 Met Gln Leu His Gly Lys Gly Ser Gln Asp Pro Ser Thr Lys Val His 210 215 220 Ile Lys Ala Leu Gln Thr Val Ile Phe Phe Leu Leu Leu Cys Ala Val 225 230 235 240 Tyr Phe Leu Ser Ile Met Ile Ser Val Trp Ser Phe Gly Ser Leu Glu 245 250 255 Asn Lys Pro Val Phe Met Phe Cys Lys Ala Ile Arg Phe Ser Tyr Pro 260 265 270 Ser Ile His Pro Phe Ile Leu Ile Trp Gly Asn Lys Lys Leu Lys Gln 275 280 285 Thr Phe Leu Ser Val Leu Arg Gln Val Arg Tyr Trp Val Lys Gly Glu 290 295 300 Lys Pro Ser Ser Pro 305 <210> 693 <211> 900 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(900) <400> 693 atg ata act ttt cta tac att ttt ttt tca att cta ata atg gtt tta 48 Me t Ile Thr Phe Leu Tyr Ile Phe Phe Ser Ile Leu Ile Met Val Leu 1 5 10 15 ttt gtt ctc gga aac ttt gcc aat ggc ttc ata gca ctg gta aat ttc 96 Phe Val Leu Gly Asn Phe Ala Asn Gly Phe Ile Ala Leu Val Asn Phe 20 25 30 att gac tgg gtg aag aga aaa aag atc tcc tca gct gac caa att ctc 144 Ile Asp Trp Val Lys Arg Lys Lys Ile Ser Ser Ala Asp Gln Ile Leu 35 40 45 act gct ctg gcg gtc tcc aga att ggt ttg ctc tgg gca tta tta tta 192 Thr Ala Leu Ala Val Ser Arg Ile Gly Leu Leu Trp Ala Leu Leu Leu 50 55 60 aat tgg tat tta act gtg ttg aat cca gct ttt tat agt gta gaa tta 240 Asn Trp Tyr Leu Thr Val Leu Asn Pro Ala Phe Tyr Ser Val Glu Leu 65 70 75 80 aga att act tct tat aat gcc tgg gtt gta acc aac cat ttc agc atg 288 Arg Ile Thr Ser Tyr Asn Ala Trp Val Val Thr Asn His Phe Ser Met 85 90 95 tgg ctt gct gct aac ctc agc ata ttt tat ttg ctc aag att gcc aat 336 Trp Leu Ala Ala Asn Leu Ser Ile Phe Tyr Leu Leu Lys Ile Ala Asn 100 105 110 ttc tcc aac ctt ctt ttt ctt cat tta aag agg aga gtt agg agt gtc 384 Phe Ser Asn Leu Leu Phe Leu His Leu Lys Arg Arg Val Arg Ser Val 115 120 125 att ctg gtg ata ctg ttg ggg act ttg ata ttt ttg gtt tgt cat ctt 432 Ile Leu Val Ile Leu Leu Gly Thr Leu Ile Phe Leu Val Cys His Leu 130 135 140 ctt gtg gca aac atg gat gag agt atg tgg gca gaa gaa tat gaa gga 480 Leu Val Ala Asn Met Asp Glu Ser Met Trp Ala Glu Glu Tyr Glu Gly 145 150 155 160 aac atg act ggg aag atg aaa ttg agg aat aca gta cat ctt tca tat 528 Asn Met Thr Gly Lys Met Lys Leu Arg Asn Thr Val His Leu Ser Tyr 165 170 175 ttg act gta act acc cta tgg agc ttc ata ccc ttt act ctg tcc ctg 576 Leu Thr Val Thr Thr Leu Trp Ser Phe Ile Pro Phe Thr Leu Ser Leu 180 185 190 ata tct ttt ctg atg cta atc tgt tct ctg tgt aaa cat ctc aag aag 624 Ile Ser Phe Leu Met Leu Ile Cys Ser Leu Cys Lys His Leu Lys Lys 195 200 205 atg cag ctc cat gga gaa gga tcg caa gat ctc agc acc aag gtc cac 672 Met Gln Leu His Gly Glu Gly Ser Gln Asp Leu Ser Thr Lys Val His 210 215 220 ata aaa gct ttg caa act ctg atc tcc ttc ctc ttg tta tgt gcc att 720 Ile Lys Ala Leu Gln Thr Leu Ile Ser Phe Leu Leu Leu Cys Ala Ile 225 230 235 240 ttc ttt cta ttc cta atc gtt tcg gtt tgg agt cct agg agg ctg cgg 768 Phe Phe Leu Phe Leu Ile Val Ser Val Trp Ser Pro Arg Arg Leu Arg 245 250 255 aat gac ccg gtt gtc atg gtt agc aag gct gtt gga aac ata tat ctt 816 Asn Asp Pro Val Val Met Val Ser Lys Ala Val Gly Asn Ile Tyr Leu 260 265 270 gca ttc gac tca ttc atc cta att tgg aga acc aag aag cta aaa cac 864 Ala Phe Asp Ser Phe Ile Leu Ile Trp Arg Thr Lys Lys Leu Lys His 275 280 285 acc ttt ctt ttg att ttg tgt cag att agg tgc tga 900 Thr Phe Leu Leu Ile Leu Cys Gln Ile Arg Cys 290 295 300 <210> 694 <211> 299 <212> PRT <213> Homo sapiens <400> 694 Met Ile Thr Phe Leu Tyr Ile Phe Phe Ser Ile Leu Ile Met Val Leu 1 5 10 15 Phe Val Leu Gly Asn Phe Ala Asn Gly Phe Ile Ala Leu Val Asn Phe 20 25 30 Ile Asp Trp Val Lys Arg Lys Lys Ile Ser Ser Ala Asp Gln Ile Leu 35 40 45 Thr Ala Leu Ala Val Ser Arg Ile Gly Leu Leu Trp Ala Leu Leu Leu 50 55 60 Asn Trp Tyr Leu Thr Val Leu Asn Pro Ala Phe Tyr Ser Val Glu Leu 65 70 75 80 Arg Ile Thr Ser Tyr Asn Ala Trp Val Val Thr Asn His Phe Ser Met 85 90 95 Trp Leu Ala Ala Asn Leu Ser Ile Phe Tyr Leu Leu Lys Ile Ala Asn 100 105 110 Phe Ser Asn Leu Leu Phe Leu His Leu Lys Arg Arg Val Arg Ser Val 115 120 125 Ile Leu Val Ile Leu Leu Gly Thr Leu Ile Phe Leu Val Cys His Leu 130 135 140 Leu Val Ala Asn Met Asp Glu Ser Met Trp Ala Glu Glu Tyr Glu Gly 145 150 155 160 Asn Met Thr Gly Lys Met Lys Leu Arg Asn Thr Val His Leu Ser Tyr 165 170 175 Leu Thr Val Thr Thr Leu Trp Ser Phe Ile Pro Phe Thr Leu Ser Leu 180 185 190 Ile Ser Phe Leu Met Leu Ile Cys Ser Leu Cys Lys His Leu Lys Lys 195 200 205 Met Gln Leu His Gly Glu Gly Ser Gln Asp Leu Ser Thr Lys Val His 210 215 220 Ile Lys Ala Leu Gln Thr Leu Ile Ser Phe Leu Leu Leu Cys Ala Ile 225 230 235 240 Phe Phe Leu Phe Leu Ile Val Ser Val Trp Ser Pro Arg Arg Leu Arg 245 250 255 Asn Asp Pro Val Val Met Val Ser Lys Ala Val Gly Asn Ile Tyr Leu 260 265 270 Ala Phe Asp Ser Phe Ile Leu Ile Trp Arg Thr Lys Lys Leu Lys His 275 280 285 Thr Phe Leu Leu Ile Leu Cys Gln Ile Arg Cys 290 295
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.7 識別記号 ＦＩ テーマコート゛(参考） Ａ６１Ｋ 45/00 Ａ６１Ｐ 43/00 １０５ ４Ｃ０８４ 48/00 Ｃ０７Ｋ 14/705 ４Ｃ０８５ Ａ６１Ｐ 43/00 １０５ 16/28 ４Ｈ０４５ Ｃ０７Ｋ 14/705 19/00 16/28 Ｃ１２Ｎ 1/15 19/00 1/19 Ｃ１２Ｎ 1/15 1/21 1/19 Ｃ１２Ｑ 1/02 1/21 1/68 Ａ 5/10 Ｇ０１Ｎ 33/15 Ｚ Ｃ１２Ｑ 1/02 33/50 Ｚ 1/68 33/53 Ｄ Ｇ０１Ｎ 33/15 33/566 33/50 Ｃ１２Ｐ 21/08 33/53 Ｃ１２Ｎ 15/00 ＺＮＡＡ 33/566 Ａ６１Ｋ 37/02 // Ｃ１２Ｐ 21/08 Ｃ１２Ｎ 5/00 Ａ Ｆターム(参考） 2G045 AA34 AA35 DA13 DA36 FB02 JA01 4B024 AA01 AA11 BA44 BA63 CA04 CA07 DA01 DA02 DA05 DA11 EA04 GA11 HA14 4B063 QA01 QA13 QA18 QQ02 QQ42 QQ53 QR08 QR55 QR62 QR80 QS25 QS34 4B064 AG20 AG26 CA19 CC24 DA03 DA13 4B065 AA01X AA57X AA87X AA93Y AB01 BA02 CA24 CA25 CA44 CA46 4C084 AA01 AA06 AA13 AA17 BA22 CA53 CA56 CA59 NA14 ZB212 ZC422 4C085 AA13 AA14 BB11 CC05 DD22 DD23 DD33 EE01 4H045 AA10 AA11 BA10 CA40 DA50 DA75 EA20 EA50 FA72 FA74
Claims (47)
- 【請求項１】 ヒト由来ゲノム情報から２００〜１５０
０のアミノ酸残基からなり、６〜８個の膜貫通領域を含
むオープンリーディングフレームを抽出し、得られたオ
ープンリーディングフレームの中から既知のＧ蛋白質共
役受容体遺伝子とホモロジーを有する遺伝子を検索する
ことを特徴とするＧ蛋白質共役受容体遺伝子及び／又は
Ｇ蛋白質共役受容体蛋白質の検索方法。 - 【請求項２】 オープンリーディングフレームを抽出す
るに際して、ＤＮＡの繰返し配列に由来するオープンリ
ーディングフレーム、不確定なアミノ酸が多いオープン
リーディングフレーム、及び同一アミノ酸を２０％以上
有するオープンリーディングフレームを排除することを
特徴とする請求項１記載のＧ蛋白質共役受容体遺伝子及
び／又はＧ蛋白質共役受容体蛋白質の検索方法。 - 【請求項３】 既知のＧ蛋白質共役受容体遺伝子とホモ
ロジーを有する遺伝子が、Ｇ蛋白質共役受容体遺伝子又
はＧ蛋白質共役受容体関連遺伝子であることを特徴とす
る請求項１又は２記載のＧ蛋白質共役受容体遺伝子及び
／又はＧ蛋白質共役受容体蛋白質の検索方法。 - 【請求項４】 Ｇ蛋白質共役受容体が、内在性リガンド
を有することを特徴とする請求項１〜３のいずれか記載
のＧ蛋白質共役受容体遺伝子及び／又はＧ蛋白質共役受
容体蛋白質の検索方法。 - 【請求項５】 内在性リガンドを有するＧ蛋白質共役受
容体が、嗅覚受容体及び味覚受容体以外のＧ蛋白質共役
受容体であることを特徴とする請求項４記載のＧ蛋白質
共役受容体遺伝子及び／又はＧ蛋白質共役受容体蛋白質
の検索方法。 - 【請求項６】 内在性リガンドを有するＧ蛋白質共役受
容体が、嗅覚受容体のＧ蛋白質共役受容体であることを
特徴とする請求項４記載のＧ蛋白質共役受容体遺伝子及
び／又はＧ蛋白質共役受容体蛋白質の検索方法。 - 【請求項７】 内在性リガンドを有するＧ蛋白質共役受
容体が、味覚受容体のＧ蛋白質共役受容体であることを
特徴とする請求項４記載のＧ蛋白質共役受容体遺伝子及
び／又はＧ蛋白質共役受容体蛋白質の検索方法。 - 【請求項８】 請求項１〜７のいずれか記載のＧ蛋白質
共役受容体遺伝子及び／又はＧ蛋白質共役受容体蛋白質
の検索方法により得られることを特徴とするＧ蛋白質共
役受容体遺伝子。 - 【請求項９】 以下の(ａ)又は(ｂ)のＧ蛋白質共役受容
体蛋白質をコードする遺伝子。 (ａ)配列番号２ｎ（ｎ＝１から５１までのいずれかの整
数を示す）に示されるアミノ酸配列からなるＧ蛋白質共
役受容体蛋白質 (ｂ) 配列番号２ｎ（ｎ＝１から５１までのいずれかの
整数を示す）に示されるアミノ酸配列において、１若し
くは数個のアミノ酸が欠失、置換若しくは付加されたア
ミノ酸配列からなるＧ蛋白質共役受容体蛋白質 - 【請求項１０】 配列番号２ｎ−１（ｎ＝１から５１ま
でのいずれかの整数を示す）に示される塩基配列又はそ
の相補的配列並びにこれらの配列の一部または全部を含
むＤＮＡからなるＧ蛋白質共役受容体蛋白質をコードす
るＤＮＡ。 - 【請求項１１】 請求項１０記載の遺伝子を構成するＤ
ＮＡとストリンジェントな条件下でハイブリダイズし、
かつＧ蛋白質共役受容体蛋白質をコードするＤＮＡ。 - 【請求項１２】 以下の(ａ)又は(ｂ)のＧ蛋白質共役受
容体蛋白質をコードする遺伝子。 (ａ)配列番号２ｎ（ｎ＝５２から３３２までのいずれか
の整数を示す）に示されるアミノ酸配列からなるＧ蛋白
質共役受容体蛋白質 (ｂ) 配列番号２ｎ（ｎ＝５２から３３２までのいずれ
かの整数を示す）に示されるアミノ酸配列において、１
若しくは数個のアミノ酸が欠失、置換若しくは付加され
たアミノ酸配列からなるＧ蛋白質共役受容体蛋白質 - 【請求項１３】 配列番号２ｎ−１（ｎ＝５２から３３
２までのいずれかの整数を示す）に示される塩基配列又
はその相補的配列並びにこれらの配列の一部または全部
を含むＤＮＡからなるＧ蛋白質共役受容体蛋白質をコー
ドするＤＮＡ。 - 【請求項１４】 請求項１３記載の遺伝子を構成するＤ
ＮＡとストリンジェントな条件下でハイブリダイズし、
かつＧ蛋白質共役受容体蛋白質をコードするＤＮＡ。 - 【請求項１５】 以下の(ａ)又は(ｂ)のＧ蛋白質共役受
容体蛋白質をコードする遺伝子。 (ａ)配列番号２ｎ（ｎ＝３３３から３４７までのいずれ
かの整数を示す）に示されるアミノ酸配列からなるＧ蛋
白質共役受容体蛋白質 (ｂ) 配列番号２ｎ（ｎ＝３３３から３４７までのいず
れかの整数を示す）に示されるアミノ酸配列において、
１若しくは数個のアミノ酸が欠失、置換若しくは付加さ
れたアミノ酸配列からなるＧ蛋白質共役受容体蛋白質 - 【請求項１６】 配列番号２ｎ−１（ｎ＝３３３から３
４７までのいずれかの整数を示す）に示される塩基配列
又はその相補的配列並びにこれらの配列の一部または全
部を含むＤＮＡからなるＧ蛋白質共役受容体蛋白質をコ
ードするＤＮＡ。 - 【請求項１７】 請求項１６記載の遺伝子を構成するＤ
ＮＡとストリンジェントな条件下でハイブリダイズし、
かつＧ蛋白質共役受容体蛋白質をコードするＤＮＡ。 - 【請求項１８】 請求項１〜７のいずれか記載のＧ蛋白
質共役受容体遺伝子及び／又はＧ蛋白質共役受容体蛋白
質の検索方法により得られることを特徴とするＧ蛋白質
共役受容体蛋白質。 - 【請求項１９】 配列番号２ｎ（ｎ＝１から５１までの
いずれかの整数を示す）に示されるアミノ酸配列からな
るＧ蛋白質共役受容体蛋白質。 - 【請求項２０】 配列番号２ｎ（ｎ＝１から５１までの
いずれかの整数を示す）に示されるアミノ酸配列におい
て、１若しくは数個のアミノ酸が欠失、置換若しくは付
加されたアミノ酸配列からなるＧ蛋白質共役受容体蛋白
質。 - 【請求項２１】 配列番号２ｎ（ｎ＝５２から３３２ま
でのいずれかの整数を示す）に示されるアミノ酸配列か
らなるＧ蛋白質共役受容体蛋白質。 - 【請求項２２】 配列番号２ｎ（ｎ＝５２から３３２ま
でのいずれかの整数を示す）に示されるアミノ酸配列に
おいて、１若しくは数個のアミノ酸が欠失、置換若しく
は付加されたアミノ酸配列からなるＧ蛋白質共役受容体
蛋白質。 - 【請求項２３】 配列番号２ｎ（ｎ＝３３３から３４７
までのいずれかの整数を示す）に示されるアミノ酸配列
からなるＧ蛋白質共役受容体蛋白質。 - 【請求項２４】 配列番号２ｎ（ｎ＝３３３から３４７
までのいずれかの整数を示す）に示されるアミノ酸配列
において、１若しくは数個のアミノ酸が欠失、置換若し
くは付加されたアミノ酸配列からなるＧ蛋白質共役受容
体蛋白質。 - 【請求項２５】 請求項１〜７のいずれか記載のＧ蛋白
質共役受容体遺伝子及び／又はＧ蛋白質共役受容体蛋白
質の検索方法により得られるＧ蛋白質共役受容体蛋白質
の部分ペプチド。 - 【請求項２６】 Ｇ蛋白質共役受容体蛋白質が、請求項
１９〜２４のいずれか記載のＧ蛋白質共役受容体蛋白質
であることを特徴とする請求項２５記載の部分ペプチ
ド。 - 【請求項２７】 請求項１８記載のＧ蛋白質共役受容体
蛋白質又は請求項２５記載のＧ蛋白質共役受容体蛋白質
の部分ペプチドと、マーカー蛋白質及び／又はペプチド
タグとを結合させた融合蛋白質又は融合ペプチド。 - 【請求項２８】 Ｇ蛋白質共役受容体蛋白質が、請求項
１９〜２４のいずれか記載のＧ蛋白質共役受容体蛋白質
であることを特徴とする請求項２７記載の融合蛋白質。 - 【請求項２９】 請求項１８記載のＧ蛋白質共役受容体
蛋白質に特異的に結合する抗体。 - 【請求項３０】 Ｇ蛋白質共役受容体蛋白質が、請求項
１９〜２４のいずれか記載のＧ蛋白質共役受容体蛋白質
であることを特徴とする請求項２９記載の抗体。 - 【請求項３１】 請求項１８記載のＧ蛋白質共役受容体
蛋白質を発現することができる発現系を含んでなる宿主
細胞。 - 【請求項３２】 Ｇ蛋白質共役受容体蛋白質が、請求項
１９〜２４のいずれか記載のＧ蛋白質共役受容体蛋白質
であることを特徴とする請求項３１記載の宿主細胞。 - 【請求項３３】 請求項１８記載のＧ蛋白質共役受容体
蛋白質をコードする遺伝子機能が染色体上で欠損し又は
前記蛋白質が過剰発現することを特徴とする非ヒト動
物。 - 【請求項３４】 Ｇ蛋白質共役受容体蛋白質が、請求項
１９〜２４のいずれか記載のＧ蛋白質共役受容体蛋白質
であることを特徴とする請求項３３記載の非ヒト動物。 - 【請求項３５】 非ヒト動物がマウスであることを特徴
とする請求項３３又は３４記載の非ヒト動物。 - 【請求項３６】 請求項１８〜２４のいずれか記載のＧ
蛋白質共役受容体蛋白質、請求項２５若しくは２６記載
の部分ペプチド、又は前記蛋白質若しくは部分ペプチド
を発現している細胞の膜と、被検物質とを用いることを
特徴とするＧ蛋白質共役受容体の機能促進若しくは抑制
物質又はＧ蛋白質共役受容体の発現促進若しくは抑制物
質のスクリーニング方法。 - 【請求項３７】 請求項１８〜２４のいずれか記載のＧ
蛋白質共役受容体蛋白質、請求項２５若しくは２６記載
の部分ペプチド、又は前記蛋白質若しくは部分ペプチド
を発現している細胞の膜と、Ｇ蛋白質又はＧ蛋白質の部
分ペプチドと、被検物質とを用いることを特徴とするＧ
蛋白質共役受容体の機能促進若しくは抑制物質又はＧ蛋
白質共役受容体の発現促進若しくは抑制物質のスクリー
ニング方法。 - 【請求項３８】 請求項１８〜２４のいずれか記載のＧ
蛋白質共役受容体蛋白質又は請求項２５若しくは２６記
載の部分ペプチドを発現している細胞と、被検物質とを
用いることを特徴とするＧ蛋白質共役受容体の機能促進
若しくは抑制物質又はＧ蛋白質共役受容体の発現促進若
しくは抑制物質のスクリーニング方法。 - 【請求項３９】 請求項１８〜２４のいずれか記載のＧ
蛋白質共役受容体蛋白質又は請求項２５若しくは２６記
載の部分ペプチドを発現している細胞が、請求項３１又
は３２記載の宿主細胞であることを特徴とする請求項３
６〜３８のいずれか記載のＧ蛋白質共役受容体の機能促
進若しくは抑制物質又はＧ蛋白質共役受容体の発現促進
若しくは抑制物質のスクリーニング方法。 - 【請求項４０】 請求項３３〜３５のいずれか記載の非
ヒト動物と、被検物質とを用いることを特徴とするＧ蛋
白質共役受容体の機能促進若しくは抑制物質又はＧ蛋白
質共役受容体の発現促進若しくは抑制物質のスクリーニ
ング方法。 - 【請求項４１】 請求項３６〜４０のいずれか記載のＧ
蛋白質共役受容体の機能促進若しくは抑制物質又はＧ蛋
白質共役受容体の発現促進若しくは抑制物質のスクリー
ニング方法により得られることを特徴とするＧ蛋白質共
役受容体の機能促進若しくは抑制物質又はＧ蛋白質共役
受容体の発現促進若しくは抑制物質。 - 【請求項４２】 Ｇ蛋白質共役受容体の機能促進若しく
は抑制物質又はＧ蛋白質共役受容体の発現促進若しくは
抑制物質が、Ｇ蛋白質共役受容体のリガンドであること
を特徴とする請求項４１記載のＧ蛋白質共役受容体の機
能促進若しくは抑制物質又はＧ蛋白質共役受容体の発現
促進若しくは抑制物質。 - 【請求項４３】 Ｇ蛋白質共役受容体の機能促進又は発
現増強を必要としている患者を治療するのに用いられる
医薬組成物であって、有効成分として請求項１８〜２４
のいずれか記載の蛋白質、請求項２５若しくは２６記載
の部分ペプチド、又は請求項４１若しくは４２記載のＧ
蛋白質共役受容体の機能又は発現を促進する物質を含ん
でなる医薬組成物。 - 【請求項４４】 Ｇ蛋白質共役受容体の機能又は発現の
抑制を必要としている患者を治療するのに用いられる医
薬組成物であって、有効成分として請求項１８〜２４の
いずれか記載の蛋白質、請求項２５若しくは２６記載の
部分ペプチド、又は請求項４１若しくは４２記載のＧ蛋
白質共役受容体の機能又は発現を抑制する物質を含んで
なる医薬組成物。 - 【請求項４５】 検体中のＧ蛋白質共役受容体蛋白質を
コードするＤＮＡ配列を、請求項１８〜２４のいずれか
記載の蛋白質をコードするＤＮＡ配列と比較することを
特徴とするＧ蛋白質共役受容体の機能又は発現に関連す
る疾病の診断方法。 - 【請求項４６】 請求項１８〜２４のいずれか記載の蛋
白質をコードするＤＮＡ又はＲＮＡのアンチセンス鎖の
全部又は一部からなるＧ蛋白質共役受容体の機能又は発
現に関連する疾病の診断用プローブ。 - 【請求項４７】 請求項４６記載の診断用プローブ及び
／又は請求項２９又は３０記載の抗体を含有することを
特徴とするＧ蛋白質共役受容体の機能又は発現に関連す
る疾病の診断薬。
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001034434A JP2002112793A (ja) | 2000-08-04 | 2001-02-09 | 新規ｇ蛋白質共役受容体 |
| PCT/IB2001/001446 WO2002016548A2 (fr) | 2000-08-04 | 2001-07-30 | Recepteur couple a une proteine g |
| CA002418130A CA2418130A1 (en) | 2000-08-04 | 2001-07-30 | Novel g protein-coupled receptor |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000-237818 | 2000-08-04 | ||
| JP2000237818 | 2000-08-04 | ||
| JP2001034434A JP2002112793A (ja) | 2000-08-04 | 2001-02-09 | 新規ｇ蛋白質共役受容体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2002112793A true JP2002112793A (ja) | 2002-04-16 |
Family
ID=26597447
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001034434A Pending JP2002112793A (ja) | 2000-08-04 | 2001-02-09 | 新規ｇ蛋白質共役受容体 |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JP2002112793A (ja) |
| CA (1) | CA2418130A1 (ja) |
| WO (1) | WO2002016548A2 (ja) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002103005A1 (en) * | 2001-06-18 | 2002-12-27 | National Institute Of Advanced Industrial Science And Technology | Guanosine triphosphate-binding protein-coupled receptors |
| JP2004508843A (ja) * | 2000-09-22 | 2004-03-25 | ケムコム エス．エー． | 嗅覚及びフェロモンのｇタンパク質共役型受容体 |
| US9141755B2 (en) | 2010-08-26 | 2015-09-22 | National Institute Of Biomedical Innovation | Device and method for selecting genes and proteins |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE42190E1 (en) | 1998-11-20 | 2011-03-01 | Arena Pharmaceuticals, Inc. | Method of identifying a compound for inhibiting or stimulating human G protein-coupled receptors |
| US20030017528A1 (en) | 1998-11-20 | 2003-01-23 | Ruoping Chen | Human orphan G protein-coupled receptors |
| US7816492B2 (en) | 1998-11-20 | 2010-10-19 | Arena Pharmaceuticals, Inc. | Human G protein-coupled receptors |
| US7361338B2 (en) | 1999-10-05 | 2008-04-22 | Agensys, Inc. | Methods to inhibit growth of prostate cancer cells |
| US6790631B1 (en) | 1999-10-05 | 2004-09-14 | Agensys, Inc. | G protein-coupled receptor up-regulated in prostate cancer and uses thereof |
| US7208280B2 (en) | 1999-10-05 | 2007-04-24 | Agensys, Inc. | Nucleic acid and corresponding protein entitled 101P3A41 useful in treatment and detection of cancer |
| AU5125801A (en) | 2000-04-07 | 2001-10-23 | Senomyx Inc | T2r taste receptors and genes encoding same |
| DE60142079D1 (de) | 2000-11-17 | 2010-06-17 | Banyu Pharma Co Ltd | Verfahren zur suche nach komponenten, in dem das guanosintriphosphat- (gtp-) bindungsprotein gekoppeltes rezeptorprotein bg37 verwendet wird |
| US7312086B2 (en) | 2000-12-07 | 2007-12-25 | Bristol-Myers Squibb Company | Methods of diagnosing colon adenocarcinoma using the human g-protein coupled receptor hgprbmy23 |
| CA2454566A1 (en) | 2001-07-20 | 2003-01-30 | The Government Of The United States Of America, As Represented By The Se Cretary, Department Of Health And Human Services | Phenylthiocarbamide (ptc) taste receptor |
| WO2003031604A1 (en) * | 2001-10-12 | 2003-04-17 | The Regents Of The University Of California | Gastrointestinal chemosensory receptors |
| ATE533507T1 (de) * | 2002-04-01 | 2011-12-15 | Agensys Inc | Nukleinsäure und entsprechendes protein mit der bezeichnung 238p1b2, geeignet zur behandlung und zum nachweis von krebs |
| US20040016004A1 (en) | 2002-04-01 | 2004-01-22 | Raitano Arthur B. | Nucleic acid and corresponding protein entitled 238P1B2 useful in treatment and detection of cancer |
| WO2003087362A1 (en) * | 2002-04-03 | 2003-10-23 | Banyu Pharmaceutical Co., Ltd. | Novel g protein-coupled receptor gene and protein bg8 |
| JP2004049043A (ja) * | 2002-07-17 | 2004-02-19 | Univ Nihon | Ｇｐｃｒ遺伝子の単離方法及び新規ｇｐｃｒ遺伝子 |
| US7056685B1 (en) | 2002-11-05 | 2006-06-06 | Amgen Inc. | Receptor ligands and methods of modulating receptors |
| AU2004258071A1 (en) | 2003-06-19 | 2005-01-27 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Variants of human taste receptor genes |
| DE10344799A1 (de) * | 2003-09-26 | 2005-04-14 | Ganymed Pharmaceuticals Ag | Identifizierung von Oberflächen-assoziierten Antigenen für die Tumordiagnose und -therapie |
| AU2011213901B2 (en) * | 2003-09-26 | 2012-07-05 | BioNTech SE | Identification of tumour-associated cell surface antigens for diagnosis and therapy |
| CN101801954B (zh) | 2007-09-20 | 2013-10-09 | Irm责任有限公司 | 作为gpr119活性调节剂的化合物和组合物 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2338336A1 (en) * | 1998-07-23 | 2000-02-03 | Takeda Chemical Industries, Ltd. | A novel g protein-coupled receptor protein and its dna thereof |
| JP2000050875A (ja) * | 1998-08-07 | 2000-02-22 | Kazusa Dna Kenkyusho | 新規ｇ蛋白質共役型レセプター蛋白質およびそのｄｎａ |
-
2001
- 2001-02-09 JP JP2001034434A patent/JP2002112793A/ja active Pending
- 2001-07-30 CA CA002418130A patent/CA2418130A1/en not_active Abandoned
- 2001-07-30 WO PCT/IB2001/001446 patent/WO2002016548A2/ja active Application Filing
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004508843A (ja) * | 2000-09-22 | 2004-03-25 | ケムコム エス．エー． | 嗅覚及びフェロモンのｇタンパク質共役型受容体 |
| WO2002103005A1 (en) * | 2001-06-18 | 2002-12-27 | National Institute Of Advanced Industrial Science And Technology | Guanosine triphosphate-binding protein-coupled receptors |
| WO2002103006A1 (en) * | 2001-06-18 | 2002-12-27 | National Institute Of Advanced Industrial Science And Technology | Guanosine triphosphate-binding protein-coupled receptors |
| US9141755B2 (en) | 2010-08-26 | 2015-09-22 | National Institute Of Biomedical Innovation | Device and method for selecting genes and proteins |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002016548A3 (fr) | 2002-06-27 |
| WO2002016548A8 (fr) | 2003-02-27 |
| CA2418130A1 (en) | 2003-02-03 |
| WO2002016548A2 (fr) | 2002-02-28 |
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