WO2002016548A3 - Recepteur couple a une proteine g - Google Patents

Recepteur couple a une proteine g Download PDF

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Publication number
WO2002016548A3
WO2002016548A3 PCT/IB2001/001446 IB0101446W WO0216548A3 WO 2002016548 A3 WO2002016548 A3 WO 2002016548A3 IB 0101446 W IB0101446 W IB 0101446W WO 0216548 A3 WO0216548 A3 WO 0216548A3
Authority
WO
WIPO (PCT)
Prior art keywords
orfs
gene
gpcr
protein
novel
Prior art date
Application number
PCT/IB2001/001446
Other languages
English (en)
Japanese (ja)
Other versions
WO2002016548A2 (fr
WO2002016548A8 (fr
Inventor
Tatsuya Haga
Shigeki Takeda
Shigeki Mitaku
Original Assignee
Japan Science & Tech Corp
Tatsuya Haga
Shigeki Takeda
Shigeki Mitaku
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Science & Tech Corp, Tatsuya Haga, Shigeki Takeda, Shigeki Mitaku filed Critical Japan Science & Tech Corp
Priority to CA002418130A priority Critical patent/CA2418130A1/fr
Priority to US10/343,650 priority patent/US20040067499A1/en
Publication of WO2002016548A2 publication Critical patent/WO2002016548A2/fr
Publication of WO2002016548A3 publication Critical patent/WO2002016548A3/fr
Publication of WO2002016548A8 publication Critical patent/WO2002016548A8/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention concerne un gène récepteur couplé à une protéine G (GPCR) permettant de trouver un mécanisme de transduction des signaux in vivo ou d'identifier une protéine cible de médicament et un procédé de recherche complète d'une protéine GPCR dans une base de données. Des cadres de lecture ouverts (ORF) contenant entre 250 et 1000 résidus d'aminoacides sont extraits des données génome d'origine humaine et des ORF provenant de séquences d'ADN répétées, des ORF contenant plusieurs aminoacides indéfinis et des ORF possédant un seul aminoacide dans un rapport d'au moins 20 % y sont exclus. Ensuite, les ORF contenant 6 à 8 domaines transmembranaires sont extraits au moyen de SOSUI. Parmi les ORF ainsi obtenus, un gène homologue comprenant un gène GPCR connu (de préférence, un gène démontrant la plus grande homologie avec un gène GPCR ou un gène associé à GPCR dans la recherche d'homologie) est recherché.
PCT/IB2001/001446 2000-08-04 2001-07-30 Recepteur couple a une proteine g WO2002016548A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA002418130A CA2418130A1 (fr) 2000-08-04 2001-07-30 Recepteur couple a une proteine g
US10/343,650 US20040067499A1 (en) 2000-08-04 2001-07-30 Novel g protein-coupled receptor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000237818 2000-08-04
JP2001034434A JP2002112793A (ja) 2000-08-04 2001-02-09 新規ｇ蛋白質共役受容体

Publications (3)

Publication Number Publication Date
WO2002016548A2 WO2002016548A2 (fr) 2002-02-28
WO2002016548A3 true WO2002016548A3 (fr) 2002-06-27
WO2002016548A8 WO2002016548A8 (fr) 2003-02-27

Family

ID=26597447

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2001/001446 WO2002016548A2 (fr) 2000-08-04 2001-07-30 Recepteur couple a une proteine g

Country Status (3)

Country Link
JP (1) JP2002112793A (fr)
CA (1) CA2418130A1 (fr)
WO (1) WO2002016548A2 (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030017528A1 (en) 1998-11-20 2003-01-23 Ruoping Chen Human orphan G protein-coupled receptors
USRE42190E1 (en) 1998-11-20 2011-03-01 Arena Pharmaceuticals, Inc. Method of identifying a compound for inhibiting or stimulating human G protein-coupled receptors
US7816492B2 (en) 1998-11-20 2010-10-19 Arena Pharmaceuticals, Inc. Human G protein-coupled receptors
US6790631B1 (en) 1999-10-05 2004-09-14 Agensys, Inc. G protein-coupled receptor up-regulated in prostate cancer and uses thereof
US7208280B2 (en) 1999-10-05 2007-04-24 Agensys, Inc. Nucleic acid and corresponding protein entitled 101P3A41 useful in treatment and detection of cancer
US7361338B2 (en) 1999-10-05 2008-04-22 Agensys, Inc. Methods to inhibit growth of prostate cancer cells
AU5125801A (en) 2000-04-07 2001-10-23 Senomyx Inc T2r taste receptors and genes encoding same
CA2421865C (fr) * 2000-09-22 2013-09-03 Chemcom S.A. Recepteurs couples a une proteine g olfactive et de pheromones
EP1347052B1 (fr) * 2000-11-17 2010-05-05 Banyu Pharmaceutical Co., Ltd. Procédé pour cribler les composantes, qui utilise le bg37, proteine du recepteur couple aux proteines g de liaison de guanosine triphosphate (gtp)
US7312086B2 (en) 2000-12-07 2007-12-25 Bristol-Myers Squibb Company Methods of diagnosing colon adenocarcinoma using the human g-protein coupled receptor hgprbmy23
US20030143668A1 (en) * 2001-06-18 2003-07-31 National Institute Of Advanced Industrial Guanosine triphosphate-binding protein coupled receptors
EP1523308A4 (fr) 2001-07-20 2007-01-10 Us Gov Health & Human Serv Recepteur du gout de la phenylthiocarbamide (ptc)
EP1442117A4 (fr) * 2001-10-12 2005-04-27 Univ California Recepteurs gastro-intestinaux chimiosensibles
US20040016004A1 (en) 2002-04-01 2004-01-22 Raitano Arthur B. Nucleic acid and corresponding protein entitled 238P1B2 useful in treatment and detection of cancer
ES2375351T3 (es) * 2002-04-01 2012-02-29 Agensys, Inc. Ácido nucleico y proteína correspondiente denominada 238p1b2 útil en el tratamiento y la detección de cáncer.
AU2003236351A1 (en) * 2002-04-03 2003-10-27 Banyu Pharmaceutical Co., Ltd. Novel g protein-coupled receptor gene and protein bg8
JP2004049043A (ja) * 2002-07-17 2004-02-19 Univ Nihon Ｇｐｃｒ遺伝子の単離方法及び新規ｇｐｃｒ遺伝子
US7056685B1 (en) 2002-11-05 2006-06-06 Amgen Inc. Receptor ligands and methods of modulating receptors
AU2004258071A1 (en) 2003-06-19 2005-01-27 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Variants of human taste receptor genes
DE10344799A1 (de) * 2003-09-26 2005-04-14 Ganymed Pharmaceuticals Ag Identifizierung von Oberflächen-assoziierten Antigenen für die Tumordiagnose und -therapie
AU2011213901B2 (en) * 2003-09-26 2012-07-05 BioNTech SE Identification of tumour-associated cell surface antigens for diagnosis and therapy
MX2010003117A (es) 2007-09-20 2010-04-01 Irm Llc Compuestos y composiciones como moduladores de la actividad de gpr119.
JP5930266B2 (ja) 2010-08-26 2016-06-08 国立研究開発法人医薬基盤・健康・栄養研究所 遺伝子絞り込み装置、遺伝子絞り込み方法、及びコンピュータプログラム

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000005264A1 (fr) * 1998-07-23 2000-02-03 Takeda Chemical Industries, Ltd. Nouvelle proteine receptrice conjuguee a la proteine g et adn de cette derniere
WO2000008053A1 (fr) * 1998-08-07 2000-02-17 Takeda Chemical Industries, Ltd. Proteine recepteur couplee a une nouvelle proteine g et son adn

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000005264A1 (fr) * 1998-07-23 2000-02-03 Takeda Chemical Industries, Ltd. Nouvelle proteine receptrice conjuguee a la proteine g et adn de cette derniere
WO2000008053A1 (fr) * 1998-08-07 2000-02-17 Takeda Chemical Industries, Ltd. Proteine recepteur couplee a une nouvelle proteine g et son adn

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
MITAKU S. ET AL.: "Proportion of membrane proteins in proteomes of 15 single-cell organisms analyzed by the SOSUI prediction system", BIOPHYS. CHEM., vol. 82, no. 2-3, 1999, pages 165 - 171, XP002908501 *
MITAKU S.: "Homology no nai amino-san hairetsu kara no tanpakushitsu kozo kino joho no chuushutsu", GENOME SCIENCE; HITO GENOME KAISEKI NI MOTOZUKU BIOSCIENCE NO SHIN-TENKAI, 1999, pages 367 - 370, XP002908502 *
MOMBAERTS P.: "Seven-transmembrane proteins as odorant and chemosensory receptors", SCIENCE, vol. 286, no. 5440, 1999, pages 707 - 711, XP002945076 *
SUWA MAKIKO ET AL.: "Amino-san hairetsu joho kara no receptor tanpakushitsu no kozo yosoku to drug design ni okeru igi", FINE CHEMICAL, vol. 27, no. 19, 1998, pages 7 - 17, XP002908503 *
TAKEDA S. ET AL.: "Systematic search for G-protein-coupled receptor genes from human genome database", JPN. J. PHARMACOL., vol. 85, no. SUPPL. 1, March 2001 (2001-03-01), pages 167P, XP002908505 *
ZHAO H. ET AL.: "Vertebrate odorant receptors", CELL. MOL. LIFE SCI., vol. 56, no. 7-8, 1999, pages 647 - 659, XP002908504 *

Also Published As

Publication number Publication date
WO2002016548A2 (fr) 2002-02-28
JP2002112793A (ja) 2002-04-16
WO2002016548A8 (fr) 2003-02-27
CA2418130A1 (fr) 2003-02-03

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