WO2002016548A8 - Recepteur couple a une proteine g - Google Patents

Recepteur couple a une proteine g

Info

Publication number
WO2002016548A8
WO2002016548A8 PCT/IB2001/001446 IB0101446W WO0216548A8 WO 2002016548 A8 WO2002016548 A8 WO 2002016548A8 IB 0101446 W IB0101446 W IB 0101446W WO 0216548 A8 WO0216548 A8 WO 0216548A8
Authority
WO
WIPO (PCT)
Prior art keywords
orfs
gene
gpcr
protein
novel
Prior art date
Application number
PCT/IB2001/001446
Other languages
English (en)
Japanese (ja)
Other versions
WO2002016548A2 (fr
WO2002016548A3 (fr
Inventor
Tatsuya Haga
Shigeki Takeda
Shigeki Mitaku
Original Assignee
Japan Science & Tech Corp
Tatsuya Haga
Shigeki Takeda
Shigeki Mitaku
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Science & Tech Corp, Tatsuya Haga, Shigeki Takeda, Shigeki Mitaku filed Critical Japan Science & Tech Corp
Priority to CA002418130A priority Critical patent/CA2418130A1/fr
Priority to US10/343,650 priority patent/US20040067499A1/en
Publication of WO2002016548A2 publication Critical patent/WO2002016548A2/fr
Publication of WO2002016548A3 publication Critical patent/WO2002016548A3/fr
Publication of WO2002016548A8 publication Critical patent/WO2002016548A8/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Information Retrieval, Db Structures And Fs Structures Therefor (AREA)

Abstract

L'invention concerne un gène récepteur couplé à une protéine G (GPCR) permettant de trouver un mécanisme de transduction des signaux in vivo ou d'identifier une protéine cible de médicament et un procédé de recherche complète d'une protéine GPCR dans une base de données. Des cadres de lecture ouverts (ORF) contenant entre 250 et 1000 résidus d'aminoacides sont extraits des données génome d'origine humaine et des ORF provenant de séquences d'ADN répétées, des ORF contenant plusieurs aminoacides indéfinis et des ORF possédant un seul aminoacide dans un rapport d'au moins 20 % y sont exclus. Ensuite, les ORF contenant 6 à 8 domaines transmembranaires sont extraits au moyen de SOSUI. Parmi les ORF ainsi obtenus, un gène homologue comprenant un gène GPCR connu (de préférence, un gène démontrant la plus grande homologie avec un gène GPCR ou un gène associé à GPCR dans la recherche d'homologie) est recherché.
PCT/IB2001/001446 2000-08-04 2001-07-30 Recepteur couple a une proteine g WO2002016548A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA002418130A CA2418130A1 (fr) 2000-08-04 2001-07-30 Recepteur couple a une proteine g
US10/343,650 US20040067499A1 (en) 2000-08-04 2001-07-30 Novel g protein-coupled receptor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000237818 2000-08-04
JP2001034434A JP2002112793A (ja) 2000-08-04 2001-02-09 新規ｇ蛋白質共役受容体

Publications (3)

Publication Number Publication Date
WO2002016548A2 WO2002016548A2 (fr) 2002-02-28
WO2002016548A3 WO2002016548A3 (fr) 2002-06-27
WO2002016548A8 true WO2002016548A8 (fr) 2003-02-27

Family

ID=26597447

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2001/001446 WO2002016548A2 (fr) 2000-08-04 2001-07-30 Recepteur couple a une proteine g

Country Status (3)

Country Link
JP (1) JP2002112793A (fr)
CA (1) CA2418130A1 (fr)
WO (1) WO2002016548A2 (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7816492B2 (en) 1998-11-20 2010-10-19 Arena Pharmaceuticals, Inc. Human G protein-coupled receptors
USRE42190E1 (en) 1998-11-20 2011-03-01 Arena Pharmaceuticals, Inc. Method of identifying a compound for inhibiting or stimulating human G protein-coupled receptors
US20030017528A1 (en) 1998-11-20 2003-01-23 Ruoping Chen Human orphan G protein-coupled receptors
US7361338B2 (en) 1999-10-05 2008-04-22 Agensys, Inc. Methods to inhibit growth of prostate cancer cells
US7208280B2 (en) 1999-10-05 2007-04-24 Agensys, Inc. Nucleic acid and corresponding protein entitled 101P3A41 useful in treatment and detection of cancer
US6790631B1 (en) 1999-10-05 2004-09-14 Agensys, Inc. G protein-coupled receptor up-regulated in prostate cancer and uses thereof
WO2001077676A1 (fr) 2000-04-07 2001-10-18 Senomyx, Inc. Recepteurs gustatifs t2r et genes codant pour eux
CA2421865C (fr) * 2000-09-22 2013-09-03 Chemcom S.A. Recepteurs couples a une proteine g olfactive et de pheromones
JP4003069B2 (ja) 2000-11-17 2007-11-07 萬有製薬株式会社 新規なグアノシン三リン酸（ｇｔｐ）結合タンパク質共役型のレセプタータンパク質、ｂｇ３７
US7312086B2 (en) 2000-12-07 2007-12-25 Bristol-Myers Squibb Company Methods of diagnosing colon adenocarcinoma using the human g-protein coupled receptor hgprbmy23
US20030143668A1 (en) * 2001-06-18 2003-07-31 National Institute Of Advanced Industrial Guanosine triphosphate-binding protein coupled receptors
AU2002326429B2 (en) 2001-07-20 2007-09-20 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Phenylthiocarbamide (PTC) taste receptor
CA2463553A1 (fr) * 2001-10-12 2003-04-17 The Regents Of The University Of California Recepteurs gastro-intestinaux chimiosensibles
US20040016004A1 (en) 2002-04-01 2004-01-22 Raitano Arthur B. Nucleic acid and corresponding protein entitled 238P1B2 useful in treatment and detection of cancer
AU2002258688B2 (en) * 2002-04-01 2008-08-14 Agensys, Inc. Nucleic acid and corresponding protein entitled 238P1B2 useful in treatment and detection of cancer
AU2003236351A1 (en) * 2002-04-03 2003-10-27 Banyu Pharmaceutical Co., Ltd. Novel g protein-coupled receptor gene and protein bg8
JP2004049043A (ja) * 2002-07-17 2004-02-19 Univ Nihon Ｇｐｃｒ遺伝子の単離方法及び新規ｇｐｃｒ遺伝子
US7056685B1 (en) 2002-11-05 2006-06-06 Amgen Inc. Receptor ligands and methods of modulating receptors
AU2004258071A1 (en) 2003-06-19 2005-01-27 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Variants of human taste receptor genes
AU2011213901B2 (en) * 2003-09-26 2012-07-05 BioNTech SE Identification of tumour-associated cell surface antigens for diagnosis and therapy
DE10344799A1 (de) * 2003-09-26 2005-04-14 Ganymed Pharmaceuticals Ag Identifizierung von Oberflächen-assoziierten Antigenen für die Tumordiagnose und -therapie
CN101801954B (zh) 2007-09-20 2013-10-09 Irm责任有限公司 作为gpr119活性调节剂的化合物和组合物
US9141755B2 (en) 2010-08-26 2015-09-22 National Institute Of Biomedical Innovation Device and method for selecting genes and proteins

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2338336A1 (fr) * 1998-07-23 2000-02-03 Takeda Chemical Industries, Ltd. Nouvelle proteine receptrice de la proteine-couplee g et adn de cette derniere
JP2000050875A (ja) * 1998-08-07 2000-02-22 Kazusa Dna Kenkyusho 新規ｇ蛋白質共役型レセプター蛋白質およびそのｄｎａ

Also Published As

Publication number Publication date
JP2002112793A (ja) 2002-04-16
CA2418130A1 (fr) 2003-02-03
WO2002016548A2 (fr) 2002-02-28
WO2002016548A3 (fr) 2002-06-27

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