TJ270B - 5,6-Dichlorobenzimidazole derivatives process for their preparation pharmaceutical composition and method of treatment or prophylaxis of virus infections - Google Patents
5,6-Dichlorobenzimidazole derivatives process for their preparation pharmaceutical composition and method of treatment or prophylaxis of virus infectionsInfo
- Publication number
- TJ270B TJ270B TJ97000433A TJ97000433A TJ270B TJ 270 B TJ270 B TJ 270B TJ 97000433 A TJ97000433 A TJ 97000433A TJ 97000433 A TJ97000433 A TJ 97000433A TJ 270 B TJ270 B TJ 270B
- Authority
- TJ
- Tajikistan
- Prior art keywords
- dichlorobenzimidazole
- prophylaxis
- treatment
- pharmaceutical composition
- virus infections
- Prior art date
Links
- 238000000034 method Methods 0.000 title 2
- IPRDZAMUYMOJTA-UHFFFAOYSA-N 5,6-dichloro-1h-benzimidazole Chemical class C1=C(Cl)C(Cl)=CC2=C1NC=N2 IPRDZAMUYMOJTA-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000011321 prophylaxis Methods 0.000 title 1
- 238000011282 treatment Methods 0.000 title 1
- 230000009385 viral infection Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/052—Imidazole radicals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9413724A GB9413724D0 (en) | 1994-07-07 | 1994-07-07 | Therapeutic nucleosides |
| PCT/GB1995/001597 WO1996001833A1 (en) | 1994-07-07 | 1995-07-06 | Therapeutic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TJ270B true TJ270B (en) | 2000-08-07 |
Family
ID=10757983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TJ97000433A TJ270B (en) | 1994-07-07 | 1995-07-06 | 5,6-Dichlorobenzimidazole derivatives process for their preparation pharmaceutical composition and method of treatment or prophylaxis of virus infections |
Country Status (43)
| Country | Link |
|---|---|
| US (4) | US6077832A (cs) |
| EP (1) | EP0769017B1 (cs) |
| JP (1) | JP3225045B2 (cs) |
| KR (1) | KR100376075B1 (cs) |
| CN (2) | CN1052010C (cs) |
| AP (1) | AP736A (cs) |
| AT (1) | ATE193298T1 (cs) |
| AU (1) | AU702248B2 (cs) |
| BG (1) | BG63435B1 (cs) |
| BR (1) | BR9508237A (cs) |
| CY (1) | CY2249B1 (cs) |
| CZ (1) | CZ290800B6 (cs) |
| DE (1) | DE69517172T2 (cs) |
| DK (1) | DK0769017T3 (cs) |
| EE (1) | EE03568B1 (cs) |
| ES (1) | ES2147294T3 (cs) |
| FI (1) | FI117629B (cs) |
| GB (1) | GB9413724D0 (cs) |
| GE (1) | GEP20002298B (cs) |
| GR (1) | GR3033744T3 (cs) |
| HR (1) | HRP950382B1 (cs) |
| HU (1) | HU227679B1 (cs) |
| IL (1) | IL114492A (cs) |
| IS (1) | IS1812B (cs) |
| MD (1) | MD1838G2 (cs) |
| MX (1) | MX9606732A (cs) |
| MY (1) | MY117892A (cs) |
| NO (1) | NO308854B1 (cs) |
| NZ (1) | NZ288722A (cs) |
| OA (1) | OA10339A (cs) |
| PL (1) | PL181136B1 (cs) |
| PT (1) | PT769017E (cs) |
| RO (1) | RO117699B1 (cs) |
| RU (1) | RU2145963C1 (cs) |
| SA (1) | SA95160202B1 (cs) |
| SK (1) | SK282046B6 (cs) |
| TJ (1) | TJ270B (cs) |
| TR (1) | TR199500832A2 (cs) |
| TW (1) | TW418196B (cs) |
| UA (1) | UA66744C2 (cs) |
| WO (1) | WO1996001833A1 (cs) |
| YU (1) | YU49443B (cs) |
| ZA (1) | ZA955644B (cs) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9413724D0 (en) * | 1994-07-07 | 1994-08-24 | Wellcome Found | Therapeutic nucleosides |
| WO1997007125A1 (en) * | 1995-08-18 | 1997-02-27 | The Regents Of The University Of Michigan | 5'-substituted-ribofuranosyl benzimidazoles as antiviral agents |
| GB9518465D0 (en) * | 1995-09-09 | 1995-11-08 | Smithkline Beecham Seiyaku Kk | Pharmaceuticals |
| GB9600143D0 (en) | 1996-01-05 | 1996-03-06 | Wellcome Found | Therapeutic compounds |
| GB9600142D0 (en) * | 1996-01-05 | 1996-03-06 | Wellcome Found | Chemical compounds |
| US6214801B1 (en) | 1996-01-23 | 2001-04-10 | The Regents Of The University Of Michigan | Imidazo[1,2-a]pyridine C-nucleosides as antiviral agents |
| US6576133B2 (en) | 1996-11-13 | 2003-06-10 | Transgenomic, Inc | Method and system for RNA analysis by matched ion polynucleotide chromatography |
| US6475388B1 (en) | 1996-11-13 | 2002-11-05 | Transgenomic, Inc. | Method and system for RNA analysis by matched ion polynucleotide chromatography |
| GB2319961A (en) * | 1996-12-07 | 1998-06-10 | Glaxo Group Ltd | Pharmaceutical composition for treatment of restenosis |
| WO1998035977A1 (en) | 1997-02-13 | 1998-08-20 | Glaxo Group Limited | Benzimidazole derivatives |
| KR20010020465A (ko) | 1997-06-10 | 2001-03-15 | 그레이엄 브레레톤, 레슬리 에드워즈 | 벤즈이미다졸 유도체 |
| CN1272113A (zh) | 1997-07-30 | 2000-11-01 | 密歇根大学董事会 | 作为抗病毒剂的来苏呋喃糖基苯并咪唑类化合物 |
| US6258264B1 (en) | 1998-04-10 | 2001-07-10 | Transgenomic, Inc. | Non-polar media for polynucleotide separations |
| GB9807354D0 (en) | 1998-04-07 | 1998-06-03 | Glaxo Group Ltd | Antiviral compound |
| GB9807355D0 (en) | 1998-04-07 | 1998-06-03 | Glaxo Group Ltd | Antiviral compound |
| US6277830B1 (en) * | 1998-10-16 | 2001-08-21 | Schering Corporation | 5′-amino acid esters of ribavirin and the use of same to treat hepatitis C with interferon |
| US6576265B1 (en) | 1999-12-22 | 2003-06-10 | Acell, Inc. | Tissue regenerative composition, method of making, and method of use thereof |
| GB0008939D0 (en) | 2000-04-11 | 2000-05-31 | Glaxo Group Ltd | Process for preparing substituted benzimidazole compounds |
| RU2262344C2 (ru) * | 2001-07-25 | 2005-10-20 | Дж.Б.Кемикалс Энд Фармасьютикалс Лтд. | Фармацевтическая композиция для лечения кожных инфекций и способ ее получения |
| RU2366661C2 (ru) * | 2002-06-28 | 2009-09-10 | Айденикс (Кайман) Лимитед | Пролекарства модифицированных 2'- и 3'-нуклеозидов для лечения инфекций flaviviridae |
| EP1644011A1 (en) | 2003-06-25 | 2006-04-12 | Stephen F. Badylak | Conditioned matrix compositions for tissue restoration |
| ES2377937T3 (es) * | 2003-12-26 | 2012-04-03 | Kissei Pharmaceutical Co., Ltd. | Derivados de benzimidazol y usos médicos de los mismos |
| RU2268741C1 (ru) * | 2004-08-04 | 2006-01-27 | Государственное образовательное учреждение высшего профессионального образования "Южно-Уральский государственный университет" | Способ лечения герпетического поражения вестибулярного, спирального, тригеминального и коленчатого ганглиев |
| JPWO2006115137A1 (ja) * | 2005-04-22 | 2008-12-18 | キッセイ薬品工業株式会社 | ２−アミノベンズイミダゾール誘導体及びその医薬用途 |
| EA008737B1 (ru) * | 2005-12-07 | 2007-08-31 | Леонид Андреевич Кожемякин | Средство для профилактики и лечения конъюнктивитов и кератитов различной этиологии (варианты), способ его применения |
| US8546344B2 (en) | 2010-10-28 | 2013-10-01 | Viropharma Incorporated | Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl)-1H-benzimidazole |
| US8940707B2 (en) * | 2010-10-28 | 2015-01-27 | Viropharma Incorporated | Maribavir isomers, compositions, methods of making and methods of using |
| US8541391B2 (en) | 2010-10-28 | 2013-09-24 | Viropharma Incorporated | Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl-1H-benzimidazole |
| US9447050B2 (en) | 2011-04-05 | 2016-09-20 | The Translational Genomics Research Institute | Solid forms of curcumin |
| EP2867010A1 (en) | 2012-06-29 | 2015-05-06 | The Procter & Gamble Company | Textured fibrous webs, apparatus and methods for forming textured fibrous webs |
| ES2885424T3 (es) | 2013-03-15 | 2021-12-13 | Knopp Biosciences Llc | Imidazo(4,5-B)piridin-2-il amidas como activadores del canal Kv7 |
| DK3191457T3 (da) | 2014-09-12 | 2019-10-07 | Knopp Biosciences Llc | BENZOIMIDAZOL-1,2-YL AMIDER SOM Kv7-KANALAKTIVATORER |
| WO2016086060A1 (en) * | 2014-11-26 | 2016-06-02 | The J. David Gladstone Institutes | Methods for treating a cytomegalovirus infection |
| RU2629670C2 (ru) * | 2016-08-04 | 2017-08-31 | Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) | 2-Амино-5,6-дифтор-1-(бета-D-рибофуранозил)-бензимидазол, способ получения и противовирусная активность его в отношении вируса герпеса простого 1-го типа |
| EP3768677A4 (en) | 2018-03-19 | 2021-12-22 | Knopp Biosciences LLC | COMPOSITIONS OF KV7 CHANNEL ACTIVATORS AND METHOD OF USE |
| JP7376108B2 (ja) * | 2020-06-23 | 2023-11-08 | バイオメトリックス テクノロジーズ インコーポレイテッド | 新規なベンズイミダゾール誘導体、その製造方法及びその抗癌剤または抗ウイルス剤としての用途 |
| CN119751358A (zh) | 2022-10-12 | 2025-04-04 | 武田药品工业株式会社 | 制备马立巴韦的方法 |
| WO2024103979A1 (zh) * | 2022-11-17 | 2024-05-23 | 北京凯因科技股份有限公司 | 一种抑制疱疹病毒的化合物 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3399987A (en) * | 1965-08-02 | 1968-09-03 | United States Borax Chem | 2-alkylaminobenzimidazoles as herbicides |
| CH443777A (de) * | 1965-08-06 | 1968-02-15 | Agripat Sa | Verfahren zum Schützen textiler Keratinfasern vor Insektenfrass und Mittel zur Durchführung dieses Verfahrens |
| NL6716664A (cs) * | 1966-12-19 | 1968-06-20 | ||
| US3655901A (en) * | 1970-07-30 | 1972-04-11 | Merck & Co Inc | Method of inhibiting the formation of phenylethanalamine-n-methyl transferase with 2-aminobenzimidazoles |
| DE2130030A1 (de) * | 1971-06-18 | 1972-12-21 | Bayer Ag | Fungizide und bakterizide Mittel |
| US4002623A (en) * | 1974-08-07 | 1977-01-11 | Pfizer Inc. | Anti-inflammatory 1-[3-(dialkylamino)propyl]-2-acylaminobenzimidazoles and 2-acylamino-3-[3-(dialkylamino)-propyl]imidazo[4,5-b]pyridines |
| FR2549938B1 (fr) * | 1983-07-25 | 1987-08-07 | Fonderie Soc Gen De | Bruleur a premelange gazeux et chaudiere equipee d'un tel bruleur |
| FR2551442B1 (fr) * | 1983-09-05 | 1987-04-30 | Centre Nat Rech Scient | Nouveaux derives furaniques, leur preparation et leur application |
| CH667649A5 (en) * | 1986-09-10 | 1988-10-31 | Lonza Ag | 2-Substd. amino-benzoxazole and -benzimidazole derivs. prodn. - by reacting prim. amino cpd. with amine in presence of acid catalyst, useful as intermediates e.g. for pharmaceuticals |
| EP0304624A3 (de) * | 1987-07-29 | 1989-03-22 | F. Hoffmann-La Roche Ag | Benzimidazol-2-yl-pyridiniumverbindungen |
| IT1226100B (it) * | 1988-07-07 | 1990-12-10 | Dompe Farmaceutici Spa | Derivati benzimidazolici farmacologicamente attivi. |
| DE3924424A1 (de) * | 1989-07-24 | 1991-01-31 | Boehringer Mannheim Gmbh | Nucleosid-derivate, verfahren zu deren herstellung, deren verwendung als arzneimittel sowie deren verwendung bei der nucleinsaeure-sequenzierung |
| SE9003151D0 (sv) * | 1990-10-02 | 1990-10-02 | Medivir Ab | Nucleoside derivatives |
| US5248672A (en) * | 1990-11-01 | 1993-09-28 | The Regents Of The University Of Michigan | Polysubstituted benzimidazole nucleosides as antiviral agents |
| WO1992018517A1 (en) * | 1991-04-17 | 1992-10-29 | Yale University | Method of treating or preventing hepatitis b virus |
| ZA923641B (en) * | 1991-05-21 | 1993-02-24 | Iaf Biochem Int | Processes for the diastereoselective synthesis of nucleosides |
| ES2087962T3 (es) * | 1991-09-04 | 1996-08-01 | Stichting Rega V Z W | Derivados nucleosidos sustituidos, metodos para su preparacion y composiciones farmaceuticas que los contienen. |
| US5314903A (en) * | 1991-12-03 | 1994-05-24 | Neurosearch A/S | Benzimidazole compounds useful as calcium channel blockers |
| GB9205071D0 (en) * | 1992-03-09 | 1992-04-22 | Wellcome Found | Therapeutic nucleosides |
| WO1994008456A1 (en) * | 1992-10-21 | 1994-04-28 | The Regents Of The University Of Michigan | Polysubstituted benzimidazoles as antiviral agents |
| US5399580A (en) * | 1993-03-08 | 1995-03-21 | Burroughs Wellcome Co. | Therapeutic nucleosides-uses |
| GB9413724D0 (en) * | 1994-07-07 | 1994-08-24 | Wellcome Found | Therapeutic nucleosides |
| JP6217655B2 (ja) * | 2015-01-15 | 2017-10-25 | トヨタ自動車株式会社 | 電力変換装置 |
-
1994
- 1994-07-07 GB GB9413724A patent/GB9413724D0/en active Pending
-
1995
- 1995-07-06 NZ NZ288722A patent/NZ288722A/en not_active IP Right Cessation
- 1995-07-06 DE DE69517172T patent/DE69517172T2/de not_active Expired - Lifetime
- 1995-07-06 MX MX9606732A patent/MX9606732A/es unknown
- 1995-07-06 JP JP50355096A patent/JP3225045B2/ja not_active Expired - Lifetime
- 1995-07-06 ZA ZA955644A patent/ZA955644B/xx unknown
- 1995-07-06 AT AT95923513T patent/ATE193298T1/de active
- 1995-07-06 SK SK1688-96A patent/SK282046B6/sk not_active IP Right Cessation
- 1995-07-06 YU YU45095A patent/YU49443B/sh unknown
- 1995-07-06 WO PCT/GB1995/001597 patent/WO1996001833A1/en not_active Ceased
- 1995-07-06 EP EP95923513A patent/EP0769017B1/en not_active Expired - Lifetime
- 1995-07-06 HU HU9700034A patent/HU227679B1/hu unknown
- 1995-07-06 MD MD97-0052A patent/MD1838G2/ro unknown
- 1995-07-06 TJ TJ97000433A patent/TJ270B/xx unknown
- 1995-07-06 GE GEAP19953510A patent/GEP20002298B/en unknown
- 1995-07-06 PT PT95923513T patent/PT769017E/pt unknown
- 1995-07-06 RO RO97-00014A patent/RO117699B1/ro unknown
- 1995-07-06 DK DK95923513T patent/DK0769017T3/da active
- 1995-07-06 CZ CZ199740A patent/CZ290800B6/cs not_active IP Right Cessation
- 1995-07-06 AU AU28051/95A patent/AU702248B2/en not_active Expired
- 1995-07-06 EE EE9700013A patent/EE03568B1/xx unknown
- 1995-07-06 HR HR950382A patent/HRP950382B1/xx not_active IP Right Cessation
- 1995-07-06 RU RU97101461A patent/RU2145963C1/ru active
- 1995-07-06 US US08/765,758 patent/US6077832A/en not_active Expired - Lifetime
- 1995-07-06 MY MYPI95001894A patent/MY117892A/en unknown
- 1995-07-06 KR KR1019970700037A patent/KR100376075B1/ko not_active Expired - Lifetime
- 1995-07-06 BR BR9508237A patent/BR9508237A/pt not_active IP Right Cessation
- 1995-07-06 PL PL95318062A patent/PL181136B1/pl unknown
- 1995-07-06 ES ES95923513T patent/ES2147294T3/es not_active Expired - Lifetime
- 1995-07-06 UA UA97010040A patent/UA66744C2/xx unknown
- 1995-07-06 CN CN95194960A patent/CN1052010C/zh not_active Expired - Lifetime
- 1995-07-06 AP APAP/P/1996/000895A patent/AP736A/en active
- 1995-07-06 IL IL11449295A patent/IL114492A/en not_active IP Right Cessation
- 1995-07-07 TR TR95/00832A patent/TR199500832A2/xx unknown
- 1995-08-04 TW TW084108119A patent/TW418196B/zh not_active IP Right Cessation
- 1995-08-27 SA SA95160202A patent/SA95160202B1/ar unknown
-
1996
- 1996-12-09 IS IS4394A patent/IS1812B/is unknown
- 1996-12-24 OA OA60942A patent/OA10339A/en unknown
-
1997
- 1997-01-03 FI FI970032A patent/FI117629B/fi not_active IP Right Cessation
- 1997-01-06 BG BG101118A patent/BG63435B1/bg unknown
- 1997-01-06 NO NO970040A patent/NO308854B1/no not_active IP Right Cessation
-
1998
- 1998-12-18 US US09/216,719 patent/US5998605A/en not_active Expired - Lifetime
-
1999
- 1999-04-19 CN CN99105167A patent/CN1236616A/zh active Pending
-
2000
- 2000-01-21 US US09/489,098 patent/US6307043B1/en not_active Expired - Lifetime
- 2000-06-22 GR GR20000401439T patent/GR3033744T3/el unknown
- 2000-12-14 US US09/738,802 patent/US20010003744A1/en not_active Abandoned
-
2001
- 2001-11-26 CY CY0100041A patent/CY2249B1/xx unknown
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