SU671731A3 - Способ получени 2-/2-тенил/-4,5диметилпиридина или его солей - Google Patents
Способ получени 2-/2-тенил/-4,5диметилпиридина или его солейInfo
- Publication number
- SU671731A3 SU671731A3 SU772455453A SU2455453A SU671731A3 SU 671731 A3 SU671731 A3 SU 671731A3 SU 772455453 A SU772455453 A SU 772455453A SU 2455453 A SU2455453 A SU 2455453A SU 671731 A3 SU671731 A3 SU 671731A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- tenyl
- dimethylpyridine
- salts
- producing
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16C—SHAFTS; FLEXIBLE SHAFTS; ELEMENTS OR CRANKSHAFT MECHANISMS; ROTARY BODIES OTHER THAN GEARING ELEMENTS; BEARINGS
- F16C2300/00—Application independent of particular apparatuses
- F16C2300/10—Application independent of particular apparatuses related to size
- F16C2300/14—Large applications, e.g. bearings having an inner diameter exceeding 500 mm
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Anesthesiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Description
(54) СПОСОБ ПОЛУЧЕНИЯ 2-(2-ТЕНИЛ)-4,5ДИМЕТИЛПИРИДИНА ИЛИ ЕГО СОЛЕЙ
Изобретение относитс к способу получени не описанного в литературе 2-(2-тенил ) -4,5-диметилпиридина формулы СНг. N мулы I или его солей, заключающимс в том, что 2-тиенил-(4,5-диметил-2-пиридил)кетон формулы 5 и. 1 .-N :.
гревают до растворени щелочи. После охлаждени до 100°С внос т 52 г 2-тиенил (4,5 - диметил-2-пиридил)-кетона и 42,5 мл 80%-него гидразингидрата. Смесь нагревают 1 ч при температуре дефлегмации. Продукты , кип щие ниже 240°С, отгон ют дистилл цией и эту температуру выдерживают еще 4 ч. Затем смесь охлаждают до и выливают на лед. Образовавщийс водный раствор несколько раз экстрагируют эфиром, эфирный слой сушат безводным сульфатом магнн , растворитель отгон ют под вакуумом. Полученный масл нистый остаток перегон ют при 0,5 мм рт. ст. и извлекают фракцию, кип щую в интервале 72-113°С.
Получают 23,8 г 2-(2-тенил) -4,5 - диметилпиридина с 49%-ным выходом. Осаждают гидрохлорид, при нерекристаллизации из безводного ацетона - метанола; т. пл. 142-144°С.
CizHnNSCI.
Вычислено %: С 60,11; Н 5,89; N 5,85; CI 14,79; S 13,37.
Найдено, %: С 60,22; Н 5,95; N 5,90; С1 14,80; S 13,46.
Ф о р м у л а и 3 о б р е т е и п
Способ получени 2-(2-тенил)-4,5 - диметилпиридина формулы
f
CHj
или его солей, отличающийс тем, что 2-тиенил- (4,5-димстил - 2 - пиридил) - кетон формулы
о
V
сн.
СНз
подвергают взаимодействию с гидразингидратом и гидроокисью кали в диэтиленгликоле при температуре кипени реакционной смеси с последующим выделением целевого продукта в свободном виде или в виде соли .
Источники информации, прин тые во внимание при экспертизе 1. Бюлер К. и Пирсон Д., Органические синтезы, М., «Мир, 1973, ч. I, с. 10.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES441097A ES441097A1 (es) | 1975-09-19 | 1975-09-19 | Procedimiento para la obtencion de 2,4, 5-trimetil-tieno (3,2-f) morfano. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU671731A3 true SU671731A3 (ru) | 1979-06-30 |
Family
ID=8470007
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU762401851A SU620210A3 (ru) | 1975-09-19 | 1976-09-17 | Способ получени 2,4,5-триметилтиено (3,2- ) морфана или его солей |
| SU772455453A SU671731A3 (ru) | 1975-09-19 | 1977-02-21 | Способ получени 2-/2-тенил/-4,5диметилпиридина или его солей |
| SU772453400A SU650506A3 (ru) | 1975-09-19 | 1977-02-21 | Способ получени 2-тиенил-/4,5диметил-2-пиридил/кетона или его солей |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU762401851A SU620210A3 (ru) | 1975-09-19 | 1976-09-17 | Способ получени 2,4,5-триметилтиено (3,2- ) морфана или его солей |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU772453400A SU650506A3 (ru) | 1975-09-19 | 1977-02-21 | Способ получени 2-тиенил-/4,5диметил-2-пиридил/кетона или его солей |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS5248694A (ru) |
| AR (1) | AR210612A1 (ru) |
| AT (1) | AT347051B (ru) |
| BE (1) | BE845755A (ru) |
| CA (1) | CA1068279A (ru) |
| CH (1) | CH617195A5 (ru) |
| DE (1) | DE2639181C3 (ru) |
| ES (1) | ES441097A1 (ru) |
| FR (5) | FR2362128A1 (ru) |
| GB (1) | GB1513980A (ru) |
| NL (1) | NL7610437A (ru) |
| NZ (1) | NZ181870A (ru) |
| PT (1) | PT65547B (ru) |
| SE (2) | SE7609357L (ru) |
| SU (3) | SU620210A3 (ru) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1274913A (fr) * | 1959-09-09 | 1961-11-03 | Rohm & Haas | Procédé de cyanuration de composés nu-hétérocycliques et nitriles ainsi obtenus |
-
1975
- 1975-09-19 ES ES441097A patent/ES441097A1/es not_active Expired
-
1976
- 1976-08-24 SE SE7609357A patent/SE7609357L/xx not_active Application Discontinuation
- 1976-08-25 GB GB35397/76A patent/GB1513980A/en not_active Expired
- 1976-08-26 NZ NZ181870A patent/NZ181870A/xx unknown
- 1976-08-26 AR AR264463A patent/AR210612A1/es active
- 1976-08-31 DE DE2639181A patent/DE2639181C3/de not_active Expired
- 1976-09-01 BE BE170277A patent/BE845755A/xx unknown
- 1976-09-02 PT PT65547A patent/PT65547B/pt unknown
- 1976-09-09 FR FR7627080A patent/FR2362128A1/fr not_active Withdrawn
- 1976-09-16 AT AT687976A patent/AT347051B/de not_active IP Right Cessation
- 1976-09-17 JP JP51110886A patent/JPS5248694A/ja active Pending
- 1976-09-17 SU SU762401851A patent/SU620210A3/ru active
- 1976-09-17 CH CH1182776A patent/CH617195A5/fr not_active IP Right Cessation
- 1976-09-20 NL NL7610437A patent/NL7610437A/xx not_active Application Discontinuation
- 1976-09-20 CA CA261,567A patent/CA1068279A/en not_active Expired
-
1977
- 1977-02-21 SU SU772455453A patent/SU671731A3/ru active
- 1977-02-21 SU SU772453400A patent/SU650506A3/ru active
- 1977-03-30 FR FR7709582A patent/FR2361397A1/fr not_active Withdrawn
- 1977-03-30 FR FR7709583A patent/FR2361388A1/fr not_active Withdrawn
- 1977-03-30 FR FR7709585A patent/FR2361390A1/fr not_active Withdrawn
- 1977-03-30 FR FR7709584A patent/FR2361389A1/fr not_active Withdrawn
-
1979
- 1979-08-27 SE SE7907106A patent/SE7907106L/sv not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ES441097A1 (es) | 1977-03-16 |
| PT65547A (en) | 1976-10-01 |
| SU620210A3 (ru) | 1978-08-15 |
| DE2639181A1 (de) | 1977-03-31 |
| FR2361389A1 (fr) | 1978-03-10 |
| JPS5248694A (en) | 1977-04-18 |
| NL7610437A (nl) | 1977-03-22 |
| DE2639181C3 (de) | 1979-05-31 |
| FR2361397A1 (fr) | 1978-03-10 |
| DE2639181B2 (de) | 1978-10-05 |
| ATA687976A (de) | 1978-04-15 |
| AU1715576A (en) | 1978-03-02 |
| FR2361390A1 (fr) | 1978-03-10 |
| GB1513980A (en) | 1978-06-14 |
| SE7609357L (sv) | 1977-03-20 |
| NZ181870A (en) | 1978-11-13 |
| PT65547B (en) | 1978-03-24 |
| BE845755A (fr) | 1977-03-01 |
| CA1068279A (en) | 1979-12-18 |
| AR210612A1 (es) | 1977-08-31 |
| SE7907106L (sv) | 1979-08-27 |
| FR2362128A1 (fr) | 1978-03-17 |
| FR2361388A1 (fr) | 1978-03-10 |
| CH617195A5 (en) | 1980-05-14 |
| SU650506A3 (ru) | 1979-02-28 |
| AT347051B (de) | 1978-12-11 |
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