GB1513980A - Tetrahydropyridine derivatives and preparation thereof - Google Patents
Tetrahydropyridine derivatives and preparation thereofInfo
- Publication number
- GB1513980A GB1513980A GB35397/76A GB3539776A GB1513980A GB 1513980 A GB1513980 A GB 1513980A GB 35397/76 A GB35397/76 A GB 35397/76A GB 3539776 A GB3539776 A GB 3539776A GB 1513980 A GB1513980 A GB 1513980A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- compound
- reaction
- prepared
- tetrahydropyridine derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16C—SHAFTS; FLEXIBLE SHAFTS; ELEMENTS OR CRANKSHAFT MECHANISMS; ROTARY BODIES OTHER THAN GEARING ELEMENTS; BEARINGS
- F16C2300/00—Application independent of particular apparatuses
- F16C2300/10—Application independent of particular apparatuses related to size
- F16C2300/14—Large applications, e.g. bearings having an inner diameter exceeding 500 mm
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Anesthesiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
1513980 Tetrahydropyridine derivatives LABORATORIOS MADE SA 25 Aug 1976 [19 Sept 1975] 35397/76 Heading C2C The novel compound of Formula I and salts thereof are prepared by reaction of a compound of Formula II with methyl iodide followed by reduction with NaBH 4 . II may be prepared by hydrazine reduction of a compound of Formula III prepared by reaction of lithiophene with 2- cyano-4,5-dimethyl pyridine obtained by reaction of an alkali metal cyanide with the reaction product of 2,3-dimethylpyridine N-oxide and an alkylating agent. Compounds of Formula I above are cyclized with strong acid to give a compound of Formula IV Pharmaceutical compositions in conventional forms having analgesic activity comprise a compound of Formula I above or a salt thereof or a compound of Formula IV above and a carrier or diluent.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES441097A ES441097A1 (en) | 1975-09-19 | 1975-09-19 | Tetrahydropyridine derivatives and preparation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1513980A true GB1513980A (en) | 1978-06-14 |
Family
ID=8470007
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB35397/76A Expired GB1513980A (en) | 1975-09-19 | 1976-08-25 | Tetrahydropyridine derivatives and preparation thereof |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS5248694A (en) |
| AR (1) | AR210612A1 (en) |
| AT (1) | AT347051B (en) |
| BE (1) | BE845755A (en) |
| CA (1) | CA1068279A (en) |
| CH (1) | CH617195A5 (en) |
| DE (1) | DE2639181C3 (en) |
| ES (1) | ES441097A1 (en) |
| FR (5) | FR2362128A1 (en) |
| GB (1) | GB1513980A (en) |
| NL (1) | NL7610437A (en) |
| NZ (1) | NZ181870A (en) |
| PT (1) | PT65547B (en) |
| SE (2) | SE7609357L (en) |
| SU (3) | SU620210A3 (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1274913A (en) * | 1959-09-09 | 1961-11-03 | Rohm & Haas | Process for cyanidation of nu-heterocyclic compounds and nitriles thus obtained |
-
1975
- 1975-09-19 ES ES441097A patent/ES441097A1/en not_active Expired
-
1976
- 1976-08-24 SE SE7609357A patent/SE7609357L/en not_active Application Discontinuation
- 1976-08-25 GB GB35397/76A patent/GB1513980A/en not_active Expired
- 1976-08-26 NZ NZ181870A patent/NZ181870A/en unknown
- 1976-08-26 AR AR264463A patent/AR210612A1/en active
- 1976-08-31 DE DE2639181A patent/DE2639181C3/en not_active Expired
- 1976-09-01 BE BE170277A patent/BE845755A/en unknown
- 1976-09-02 PT PT65547A patent/PT65547B/en unknown
- 1976-09-09 FR FR7627080A patent/FR2362128A1/en not_active Withdrawn
- 1976-09-16 AT AT687976A patent/AT347051B/en not_active IP Right Cessation
- 1976-09-17 SU SU762401851A patent/SU620210A3/en active
- 1976-09-17 JP JP51110886A patent/JPS5248694A/en active Pending
- 1976-09-17 CH CH1182776A patent/CH617195A5/en not_active IP Right Cessation
- 1976-09-20 CA CA261,567A patent/CA1068279A/en not_active Expired
- 1976-09-20 NL NL7610437A patent/NL7610437A/en not_active Application Discontinuation
-
1977
- 1977-02-21 SU SU772455453A patent/SU671731A3/en active
- 1977-02-21 SU SU772453400A patent/SU650506A3/en active
- 1977-03-30 FR FR7709584A patent/FR2361389A1/en not_active Withdrawn
- 1977-03-30 FR FR7709583A patent/FR2361388A1/en not_active Withdrawn
- 1977-03-30 FR FR7709585A patent/FR2361390A1/en not_active Withdrawn
- 1977-03-30 FR FR7709582A patent/FR2361397A1/en not_active Withdrawn
-
1979
- 1979-08-27 SE SE7907106A patent/SE7907106L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CH617195A5 (en) | 1980-05-14 |
| DE2639181C3 (en) | 1979-05-31 |
| JPS5248694A (en) | 1977-04-18 |
| NL7610437A (en) | 1977-03-22 |
| PT65547B (en) | 1978-03-24 |
| SU650506A3 (en) | 1979-02-28 |
| DE2639181A1 (en) | 1977-03-31 |
| PT65547A (en) | 1976-10-01 |
| CA1068279A (en) | 1979-12-18 |
| NZ181870A (en) | 1978-11-13 |
| AU1715576A (en) | 1978-03-02 |
| AT347051B (en) | 1978-12-11 |
| ES441097A1 (en) | 1977-03-16 |
| SU620210A3 (en) | 1978-08-15 |
| AR210612A1 (en) | 1977-08-31 |
| SE7609357L (en) | 1977-03-20 |
| SE7907106L (en) | 1979-08-27 |
| BE845755A (en) | 1977-03-01 |
| FR2362128A1 (en) | 1978-03-17 |
| ATA687976A (en) | 1978-04-15 |
| DE2639181B2 (en) | 1978-10-05 |
| SU671731A3 (en) | 1979-06-30 |
| FR2361397A1 (en) | 1978-03-10 |
| FR2361389A1 (en) | 1978-03-10 |
| FR2361388A1 (en) | 1978-03-10 |
| FR2361390A1 (en) | 1978-03-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |