GB1248324A - Pyridoxine alpha-ketoglutarate and derivatives thereof - Google Patents

Pyridoxine alpha-ketoglutarate and derivatives thereof

Info

Publication number
GB1248324A
GB1248324A GB55925/69A GB5592569A GB1248324A GB 1248324 A GB1248324 A GB 1248324A GB 55925/69 A GB55925/69 A GB 55925/69A GB 5592569 A GB5592569 A GB 5592569A GB 1248324 A GB1248324 A GB 1248324A
Authority
GB
United Kingdom
Prior art keywords
pyridoxine
derivatives
ketoglutarate
formula
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB55925/69A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Made SA
Original Assignee
Laboratorios Made SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Made SA filed Critical Laboratorios Made SA
Publication of GB1248324A publication Critical patent/GB1248324A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
    • C07D213/67—2-Methyl-3-hydroxy-4,5-bis(hydroxy-methyl)pyridine, i.e. pyridoxine

Abstract

1,248,324. Pyridoxine derivatives. LABORATORIOS MADE S.A. 14 Noy., 1969 [22 Nov., 1968], No..55925/69. Heading C2V. Pyridoxine α-ketoglutarate and derivatives thereof of formula where X is a hydrogen atom, an alkali metal or alkaline earth metal or an .organic base cation, are obtained by mixing a solution of pyridoxine with a solution of α-ketoglutaric acid or derivative thereof of formula in an organic or inorganic solvent. An example is given. Pharmaceutical compositions comprise the above-described compounds together with inert non-toxic carriers, diluents or coatings.
GB55925/69A 1968-11-22 1969-11-14 Pyridoxine alpha-ketoglutarate and derivatives thereof Expired GB1248324A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES360566A ES360566A1 (en) 1968-11-22 1968-11-22 Pyridoxine alpha-ketoglutarate and derivatives thereof

Publications (1)

Publication Number Publication Date
GB1248324A true GB1248324A (en) 1971-09-29

Family

ID=8451045

Family Applications (1)

Application Number Title Priority Date Filing Date
GB55925/69A Expired GB1248324A (en) 1968-11-22 1969-11-14 Pyridoxine alpha-ketoglutarate and derivatives thereof

Country Status (8)

Country Link
BE (1) BE742026A (en)
CH (1) CH529134A (en)
DE (1) DE1958226C3 (en)
DK (1) DK133465B (en)
ES (1) ES360566A1 (en)
FR (1) FR2023937B1 (en)
GB (1) GB1248324A (en)
SE (1) SE368571B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7812037B2 (en) 2004-10-28 2010-10-12 Medicure International, Inc. Dual antiplatelet/anticoagulant pyridoxine analogs

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1141070B (en) * 1980-09-22 1986-10-01 Luso Farmaco Inst USE OF ALPHA-KETOGLUTARATE OF PYRIDOXY IN THE PROPHYLAXIS OF HYPERLACTACIDEMIA
FR2531713A2 (en) * 1981-09-16 1984-02-17 Panmedica Sa New compositions based on 5-hydroxytryptophan, process for preparing them and medicaments containing them
DE4326763A1 (en) * 1993-08-10 1995-02-16 Kirsten Schadow Trolley
US6043259A (en) * 1998-07-09 2000-03-28 Medicure Inc. Treatment of cardiovascular and related pathologies
BR0008857A (en) 1999-03-08 2001-12-18 Medicure Inc Pyridoxal analogues for vitaminab-6 disorders
WO2001003682A2 (en) 1999-07-13 2001-01-18 Medicure Inc. Use of pyridoxin derivatives for the treatment of diabetes and related complications
AU783855B2 (en) 1999-08-24 2005-12-15 Medicure International Inc. Compositions for the treatment of cardiovascular diseases containing pyridoxal compounds and cardiovascular compounds
EP1268498B1 (en) 2000-02-29 2005-04-13 Medicure International Inc. Cardioprotective phosphonates
EP1278526A2 (en) 2000-03-28 2003-01-29 Medicure International Inc. Treatment of cerebrovascular disease
US6897228B2 (en) 2000-07-07 2005-05-24 Medicure International Inc. Pyridoxine and pyridoxal analogues: new uses
US6548519B1 (en) 2001-07-06 2003-04-15 Medicure International Inc. Pyridoxine and pyridoxal analogues: novel uses
AU2001272263B2 (en) 2000-07-07 2005-12-15 Medicure International Inc. Pyridoxine and pyridoxal analogues: cardiovascular therapeutics

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7812037B2 (en) 2004-10-28 2010-10-12 Medicure International, Inc. Dual antiplatelet/anticoagulant pyridoxine analogs

Also Published As

Publication number Publication date
FR2023937A1 (en) 1970-08-21
DE1958226C3 (en) 1974-03-14
FR2023937B1 (en) 1973-04-06
SE368571B (en) 1974-07-08
DE1958226B2 (en) 1973-07-26
DE1958226A1 (en) 1970-05-27
CH529134A (en) 1972-10-15
BE742026A (en) 1970-05-21
ES360566A1 (en) 1970-10-16
DK133465C (en) 1976-11-22
DK133465B (en) 1976-05-24

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