ES360566A1 - Pyridoxine alpha-ketoglutarate and derivatives thereof - Google Patents

Pyridoxine alpha-ketoglutarate and derivatives thereof

Info

Publication number
ES360566A1
ES360566A1 ES360566A ES360566A ES360566A1 ES 360566 A1 ES360566 A1 ES 360566A1 ES 360566 A ES360566 A ES 360566A ES 360566 A ES360566 A ES 360566A ES 360566 A1 ES360566 A1 ES 360566A1
Authority
ES
Spain
Prior art keywords
pyridoxine
alpha
ketoglutarate
derivatives
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES360566A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Made SA
Original Assignee
Laboratorios Made SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Made SA filed Critical Laboratorios Made SA
Priority to ES360566A priority Critical patent/ES360566A1/en
Priority to GB55925/69A priority patent/GB1248324A/en
Priority to SE15841/69A priority patent/SE368571B/xx
Priority to DK612469AA priority patent/DK133465B/en
Priority to DE1958226A priority patent/DE1958226C3/en
Priority to CH1730969A priority patent/CH529134A/en
Priority to BE742026D priority patent/BE742026A/xx
Priority to FR696940244A priority patent/FR2023937B1/fr
Publication of ES360566A1 publication Critical patent/ES360566A1/en
Priority to CH275571A priority patent/CH540917A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
    • C07D213/67—2-Methyl-3-hydroxy-4,5-bis(hydroxy-methyl)pyridine, i.e. pyridoxine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Pyridoxine [alpha]-ketoglutarate and derivatives thereof of formula where X is a hydrogen atom, an alkali metal or alkaline earth metal or an .organic base cation, are obtained by mixing a solution of pyridoxine with a solution of [alpha]-ketoglutaric acid or derivative thereof of formula in an organic or inorganic solvent. An example is given. Pharmaceutical compositions comprise the above-described compounds together with inert non-toxic carriers, diluents or coatings.
ES360566A 1968-11-22 1968-11-22 Pyridoxine alpha-ketoglutarate and derivatives thereof Expired ES360566A1 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
ES360566A ES360566A1 (en) 1968-11-22 1968-11-22 Pyridoxine alpha-ketoglutarate and derivatives thereof
GB55925/69A GB1248324A (en) 1968-11-22 1969-11-14 Pyridoxine alpha-ketoglutarate and derivatives thereof
SE15841/69A SE368571B (en) 1968-11-22 1969-11-18
DK612469AA DK133465B (en) 1968-11-22 1969-11-19 Analogous process for the preparation of pyridoxine alpha-ketoglutarate.
DE1958226A DE1958226C3 (en) 1968-11-22 1969-11-20 Pyridoxine alpha ketoglutarate
CH1730969A CH529134A (en) 1968-11-22 1969-11-20 Process for the preparation of pyridoxine a-ketoglutarate derivatives
BE742026D BE742026A (en) 1968-11-22 1969-11-21
FR696940244A FR2023937B1 (en) 1968-11-22 1969-11-21
CH275571A CH540917A (en) 1968-11-22 1971-02-25 Alpha-ketoglutarate of pyridoxine and 5-hydroxytryptophan

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES360566A ES360566A1 (en) 1968-11-22 1968-11-22 Pyridoxine alpha-ketoglutarate and derivatives thereof

Publications (1)

Publication Number Publication Date
ES360566A1 true ES360566A1 (en) 1970-10-16

Family

ID=8451045

Family Applications (1)

Application Number Title Priority Date Filing Date
ES360566A Expired ES360566A1 (en) 1968-11-22 1968-11-22 Pyridoxine alpha-ketoglutarate and derivatives thereof

Country Status (8)

Country Link
BE (1) BE742026A (en)
CH (1) CH529134A (en)
DE (1) DE1958226C3 (en)
DK (1) DK133465B (en)
ES (1) ES360566A1 (en)
FR (1) FR2023937B1 (en)
GB (1) GB1248324A (en)
SE (1) SE368571B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1141070B (en) * 1980-09-22 1986-10-01 Luso Farmaco Inst USE OF ALPHA-KETOGLUTARATE OF PYRIDOXY IN THE PROPHYLAXIS OF HYPERLACTACIDEMIA
FR2531713A2 (en) * 1981-09-16 1984-02-17 Panmedica Sa New compositions based on 5-hydroxytryptophan, process for preparing them and medicaments containing them
DE4326763A1 (en) * 1993-08-10 1995-02-16 Kirsten Schadow Trolley
US6043259A (en) * 1998-07-09 2000-03-28 Medicure Inc. Treatment of cardiovascular and related pathologies
AU763464B2 (en) 1999-03-08 2003-07-24 Medicure Inc. Pyridoxal analogues for vitamin B-6 disorders
CA2376029A1 (en) 1999-07-13 2001-01-18 Medicure Inc. Use of pyridoxin derivatives for the treatment of diabetes and related complications
CA2383252A1 (en) 1999-08-24 2001-03-01 Medicure International Inc. Treatment of cardiovascular related pathologies
JP2003525303A (en) 2000-02-29 2003-08-26 メディキュア インターナショナル インコーポレイテッド Cardioprotective phosphonates and malonates
JP2003528146A (en) 2000-03-28 2003-09-24 メディキュア インターナショナル インコーポレイテッド Treatment of cerebrovascular disease
US6548519B1 (en) 2001-07-06 2003-04-15 Medicure International Inc. Pyridoxine and pyridoxal analogues: novel uses
WO2002004421A2 (en) 2000-07-07 2002-01-17 Medicure International Inc. Pyridoxine and pyridoxal analogues: cardiovascular therapeutics
US6897228B2 (en) 2000-07-07 2005-05-24 Medicure International Inc. Pyridoxine and pyridoxal analogues: new uses
AU2005304220A1 (en) 2004-10-28 2006-05-18 Medicure International Inc. Dual antiplatelet/anticoagulant pyridoxine analogs

Also Published As

Publication number Publication date
DE1958226A1 (en) 1970-05-27
CH529134A (en) 1972-10-15
FR2023937A1 (en) 1970-08-21
DK133465C (en) 1976-11-22
BE742026A (en) 1970-05-21
SE368571B (en) 1974-07-08
DK133465B (en) 1976-05-24
GB1248324A (en) 1971-09-29
DE1958226B2 (en) 1973-07-26
FR2023937B1 (en) 1973-04-06
DE1958226C3 (en) 1974-03-14

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