SU474968A3 - Способ получени 4-(4-бифенилил)1-бутанола - Google Patents
Способ получени 4-(4-бифенилил)1-бутанолаInfo
- Publication number
- SU474968A3 SU474968A3 SU1957826A SU1957826A SU474968A3 SU 474968 A3 SU474968 A3 SU 474968A3 SU 1957826 A SU1957826 A SU 1957826A SU 1957826 A SU1957826 A SU 1957826A SU 474968 A3 SU474968 A3 SU 474968A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- biphenylyl
- butanol
- obtaining
- palladium
- absorbed
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/09—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis
- C07C29/10—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis of ethers, including cyclic ethers, e.g. oxiranes
- C07C29/103—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis of ethers, including cyclic ethers, e.g. oxiranes of cyclic ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
- C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
- C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
- C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
- C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
- C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
- C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
- C07C29/149—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof with hydrogen or hydrogen-containing gases
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/17—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrogenation of carbon-to-carbon double or triple bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/60—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by elimination of -OH groups, e.g. by dehydration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/18—Monohydroxylic alcohols containing only six-membered aromatic rings as cyclic part
- C07C33/24—Monohydroxylic alcohols containing only six-membered aromatic rings as cyclic part polycyclic without condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/26—Polyhydroxylic alcohols containing only six-membered aromatic rings as cyclic part
Description
Н1итробензоле или мет}гленхлориде, при температуре 0-80° С.
Пример. 5,6 г (0,025 мол ) 2-{4-бифенилил ) - теграгид-рофурана (т. ,киП. 121 - 123°С/0,2 мм рт. ст.) гидрируют в 50 мл лед ной уксусной кислоты и 2 мл 85%-ной фосфорной ккслоты с добавлением 1 г паллади на угле (107о- ый) ;ири комнатной температуре и давлении 3 атм. После поглощени рассчитанного количества водорода отсасывают катализатор, смешивают фильтрат с 300 мл .воды, нейтрализуют карбонатом нагри и поглощают выделИ1Вшийс масл ный продукт эфиром. Остающийс после отгонки э.фира твердый остаток перекристаллизовывают из петролейпого эфира. Получают 3,5 г (61,8% от теоретического ) 4-(4-бифенилил)-1-бутанола с т. пл. 74-75° С.
Предмет изобретени
1. Способ получени 4-(4-бифенилил)-1бутанола , отличающийс тем, Ч|То 2-(4-бифен лил )-тетраги рофуран каталитически гидрируют ,в при:сутств ИЛ КИ1СЛОго агента и пол рного растворител с .последующим выделением целевого продукта известными приеLMaiMKi .
2.Способ ло 1П. 1, отличающийс тем, что в .качестве 1К|И,слого агента примен ют фосфо1р .ную кислоту, 1В качестве пол рного растворител - лед ную уксусную кислоту.
3.Способ по :П1П. 1 и 2, отличающийс тем, что реакцию провод т в присутствии паллади на угле при ком:натлой температуре.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2151312A DE2151312C3 (de) | 1971-10-15 | 1971-10-15 | 4- (4-Biphen ylyl) -l-butanol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU474968A3 true SU474968A3 (ru) | 1975-06-25 |
Family
ID=5822378
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1955030A SU464106A3 (ru) | 1971-10-15 | 1972-10-12 | Способ получени 4-(4-бифенилил)1 -бутанола |
| SU1957826A SU474968A3 (ru) | 1971-10-15 | 1972-10-12 | Способ получени 4-(4-бифенилил)1-бутанола |
| SU1955028A SU471710A3 (ru) | 1971-10-15 | 1972-10-12 | Способ получени 4-/4-бифенилил/1-бутанола |
| SU1839112A SU453823A3 (ru) | 1971-10-15 | 1972-10-12 | Способ получения 4- |
| SU1955026A SU464105A3 (ru) | 1971-10-15 | 1972-10-12 | Способ получени 4-(4-бифенилил)-1 бутанола |
| SU1955029A SU496714A3 (ru) | 1971-10-15 | 1973-08-23 | Способ получени 4-(4-бифенилил)1-бутанола |
| SU1955347A SU496713A3 (ru) | 1971-10-15 | 1973-08-23 | Способ получени 4-(2-бифенилил)1-бутанола |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1955030A SU464106A3 (ru) | 1971-10-15 | 1972-10-12 | Способ получени 4-(4-бифенилил)1 -бутанола |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1955028A SU471710A3 (ru) | 1971-10-15 | 1972-10-12 | Способ получени 4-/4-бифенилил/1-бутанола |
| SU1839112A SU453823A3 (ru) | 1971-10-15 | 1972-10-12 | Способ получения 4- |
| SU1955026A SU464105A3 (ru) | 1971-10-15 | 1972-10-12 | Способ получени 4-(4-бифенилил)-1 бутанола |
| SU1955029A SU496714A3 (ru) | 1971-10-15 | 1973-08-23 | Способ получени 4-(4-бифенилил)1-бутанола |
| SU1955347A SU496713A3 (ru) | 1971-10-15 | 1973-08-23 | Способ получени 4-(2-бифенилил)1-бутанола |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US3801654A (ru) |
| JP (3) | JPS5320031B2 (ru) |
| AT (7) | AT321898B (ru) |
| AU (1) | AU469279B2 (ru) |
| BE (1) | BE790086A (ru) |
| BG (5) | BG20560A3 (ru) |
| CA (1) | CA993897A (ru) |
| CH (4) | CH575358A5 (ru) |
| CS (7) | CS160610B2 (ru) |
| DD (1) | DD103233A5 (ru) |
| DE (1) | DE2151312C3 (ru) |
| DK (1) | DK129573B (ru) |
| ES (5) | ES407583A1 (ru) |
| FI (1) | FI55984C (ru) |
| FR (1) | FR2157860B1 (ru) |
| GB (1) | GB1361574A (ru) |
| HU (1) | HU164696B (ru) |
| IE (1) | IE36775B1 (ru) |
| IL (1) | IL40571A (ru) |
| NL (1) | NL7213927A (ru) |
| NO (1) | NO136092C (ru) |
| PH (1) | PH13645A (ru) |
| PL (4) | PL91408B1 (ru) |
| RO (8) | RO71306A (ru) |
| SE (2) | SE399417B (ru) |
| SU (7) | SU464106A3 (ru) |
| YU (5) | YU255972A (ru) |
| ZA (1) | ZA727320B (ru) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4053639A (en) * | 1964-01-24 | 1977-10-11 | The Boots Company Limited | Therapeutically active phenylalkane derivatives |
| BE790085A (fr) * | 1971-10-15 | 1973-04-13 | Thomae Gmbh Dr K | Nouveaux 4-(4-biphenylyl)-butanols |
| DE2240440A1 (de) * | 1972-08-17 | 1974-02-28 | Thomae Gmbh Dr K | Neue (4-biphenylyl)-alkohole und verfahren zu ihrer herstellung |
| DE2240438A1 (de) * | 1972-08-17 | 1974-02-28 | Thomae Gmbh Dr K | Neue 2-(4-biphenylyl)-tetrahydrofurane und verfahren zu ihrer herstellung |
| DE2341506A1 (de) * | 1973-08-16 | 1975-02-27 | Thomae Gmbh Dr K | Neue biphenylderivate und verfahren zu ihrer herstellung |
| DE2528958A1 (de) * | 1975-06-28 | 1977-01-13 | Merck Patent Gmbh | Araliphatische dihalogenverbindungen und verfahren zu ihrer herstellung |
| DE2708520A1 (de) * | 1977-02-26 | 1978-08-31 | Thomae Gmbh Dr K | Neue arzneimittelkombinationen und verfahren zu ihrer herstellung |
| DE3001303A1 (de) * | 1980-01-16 | 1981-07-23 | Basf Ag, 6700 Ludwigshafen | Optisch aktive phenylpropan-derivate, ihre herstellung und verwendung |
| AT399471B (de) * | 1993-06-04 | 1995-05-26 | Ifw Manfred Otte Ges M B H & C | Spritzgiessform |
-
0
- BE BE790086D patent/BE790086A/xx not_active IP Right Cessation
-
1971
- 1971-10-15 DE DE2151312A patent/DE2151312C3/de not_active Expired
-
1972
- 1972-09-22 SE SE7212263A patent/SE399417B/xx unknown
- 1972-10-04 US US00294940A patent/US3801654A/en not_active Expired - Lifetime
- 1972-10-05 AT AT573573A patent/AT321898B/de not_active IP Right Cessation
- 1972-10-05 AT AT573773A patent/AT321900B/de not_active IP Right Cessation
- 1972-10-05 AT AT573673A patent/AT321897B/de not_active IP Right Cessation
- 1972-10-05 AT AT573473A patent/AT321899B/de not_active IP Right Cessation
- 1972-10-05 AT AT573373A patent/AT321901B/de not_active IP Right Cessation
- 1972-10-05 AT AT852372A patent/AT315823B/de not_active IP Right Cessation
- 1972-10-05 AT AT573873*7A patent/AT327177B/de not_active IP Right Cessation
- 1972-10-06 PH PH13983A patent/PH13645A/en unknown
- 1972-10-11 DD DD166149A patent/DD103233A5/xx unknown
- 1972-10-12 SU SU1955030A patent/SU464106A3/ru active
- 1972-10-12 SU SU1957826A patent/SU474968A3/ru active
- 1972-10-12 SU SU1955028A patent/SU471710A3/ru active
- 1972-10-12 SU SU1839112A patent/SU453823A3/ru active
- 1972-10-12 SU SU1955026A patent/SU464105A3/ru active
- 1972-10-12 YU YU02559/72A patent/YU255972A/xx unknown
- 1972-10-13 PL PL1972173619A patent/PL91408B1/pl unknown
- 1972-10-13 CS CS5226*[A patent/CS160610B2/cs unknown
- 1972-10-13 HU HUTO891A patent/HU164696B/hu unknown
- 1972-10-13 AU AU47748/72A patent/AU469279B2/en not_active Expired
- 1972-10-13 ES ES407583A patent/ES407583A1/es not_active Expired
- 1972-10-13 PL PL1972173621A patent/PL91407B1/pl unknown
- 1972-10-13 CS CS5227*[A patent/CS160611B2/cs unknown
- 1972-10-13 GB GB4744272A patent/GB1361574A/en not_active Expired
- 1972-10-13 CS CS6922A patent/CS160609B2/cs unknown
- 1972-10-13 FI FI2841/72A patent/FI55984C/fi active
- 1972-10-13 NL NL7213927A patent/NL7213927A/xx not_active Application Discontinuation
- 1972-10-13 CS CS5229*[A patent/CS160613B2/cs unknown
- 1972-10-13 PL PL1972158243A patent/PL83601B1/pl unknown
- 1972-10-13 JP JP10314872A patent/JPS5320031B2/ja not_active Expired
- 1972-10-13 BG BG21617A patent/BG20560A3/xx unknown
- 1972-10-13 BG BG23543A patent/BG19586A3/xx unknown
- 1972-10-13 CS CS5231*[A patent/CS160615B2/cs unknown
- 1972-10-13 PL PL1972173620A patent/PL91409B1/pl unknown
- 1972-10-13 CH CH1500072A patent/CH575358A5/xx not_active IP Right Cessation
- 1972-10-13 NO NO3683/72A patent/NO136092C/no unknown
- 1972-10-13 ZA ZA727320A patent/ZA727320B/xx unknown
- 1972-10-13 CH CH72676A patent/CH590185A5/xx not_active IP Right Cessation
- 1972-10-13 FR FR7236362A patent/FR2157860B1/fr not_active Expired
- 1972-10-13 BG BG23546A patent/BG20777A3/xx unknown
- 1972-10-13 BG BG23544A patent/BG20332A3/xx unknown
- 1972-10-13 BG BG23545A patent/BG20333A3/xx unknown
- 1972-10-13 CH CH63676A patent/CH589575A5/xx not_active IP Right Cessation
- 1972-10-13 DK DK506872AA patent/DK129573B/da not_active IP Right Cessation
- 1972-10-13 CA CA153,847A patent/CA993897A/en not_active Expired
- 1972-10-13 CS CS5228*[A patent/CS160612B2/cs unknown
- 1972-10-13 IL IL40571A patent/IL40571A/xx unknown
- 1972-10-13 CS CS5230*[A patent/CS160614B2/cs unknown
- 1972-10-13 IE IE1394/72A patent/IE36775B1/xx unknown
- 1972-10-15 RO RO7283159A patent/RO71306A/ro unknown
- 1972-10-15 RO RO7283154A patent/RO70059A/ro unknown
- 1972-10-15 RO RO7283160A patent/RO71307A/ro unknown
- 1972-10-15 RO RO7283157A patent/RO70060A/ro unknown
- 1972-10-15 RO RO7283155A patent/RO70567A/ro unknown
- 1972-10-15 RO RO7283156A patent/RO69378A/ro unknown
- 1972-10-16 RO RO7283153A patent/RO70058A/ro unknown
- 1972-10-16 RO RO7272524A patent/RO71244A/ro unknown
-
1973
- 1973-05-26 ES ES415242A patent/ES415242A1/es not_active Expired
- 1973-05-26 ES ES415241A patent/ES415241A1/es not_active Expired
- 1973-05-26 ES ES415244A patent/ES415244A1/es not_active Expired
- 1973-05-26 ES ES415243A patent/ES415243A1/es not_active Expired
- 1973-08-23 SU SU1955029A patent/SU496714A3/ru active
- 1973-08-23 SU SU1955347A patent/SU496713A3/ru active
-
1976
- 1976-01-26 SE SE7600800A patent/SE7600800L/xx unknown
- 1976-04-29 CH CH206977A patent/CH599082A5/xx not_active IP Right Cessation
-
1977
- 1977-09-09 JP JP10868477A patent/JPS5387342A/ja active Granted
- 1977-09-09 JP JP10868377A patent/JPS5387341A/ja active Granted
-
1979
- 1979-08-13 YU YU01972/79A patent/YU197279A/xx unknown
- 1979-08-13 YU YU01971/79A patent/YU197179A/xx unknown
- 1979-08-13 YU YU01973/79A patent/YU197379A/xx unknown
- 1979-08-13 YU YU01974/79A patent/YU197479A/xx unknown
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