SMT202000632T1 - Composizioni antiparassitarie comprendenti un principio attivo isossazolinico, metodo e loro usi - Google Patents

Composizioni antiparassitarie comprendenti un principio attivo isossazolinico, metodo e loro usi

Info

Publication number
SMT202000632T1
SMT202000632T1 SM20200632T SMT202000632T SMT202000632T1 SM T202000632 T1 SMT202000632 T1 SM T202000632T1 SM 20200632 T SM20200632 T SM 20200632T SM T202000632 T SMT202000632 T SM T202000632T SM T202000632 T1 SMT202000632 T1 SM T202000632T1
Authority
SM
San Marino
Prior art keywords
active agent
isoxazoline active
parasiticidal compositions
parasiticidal
compositions
Prior art date
Application number
SM20200632T
Other languages
English (en)
Italian (it)
Inventor
Mark D Soll
Joseph K Rosentel
James Pate
Natalya Shub
Monica Tejwani-Motwani
Carol Belansky
Original Assignee
Boehringer Ingelheim Animal Health Usa Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47018471&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SMT202000632(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Animal Health Usa Inc filed Critical Boehringer Ingelheim Animal Health Usa Inc
Publication of SMT202000632T1 publication Critical patent/SMT202000632T1/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N49/00—Biocides, pest repellants or attractants, or plant growth regulators, containing compounds containing the group, wherein m+n>=1, both X together may also mean —Y— or a direct carbon-to-carbon bond, and the carbon atoms marked with an asterisk are not part of any ring system other than that which may be formed by the atoms X, the carbon atoms in square brackets being part of any acyclic or cyclic structure, or the group, wherein A means a carbon atom or Y, n>=0, and not more than one of these carbon atoms being a member of the same ring system, e.g. juvenile insect hormones or mimics thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/231—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having one or two double bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/15—Depsipeptides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A61K9/0017—Non-human animal skin, e.g. pour-on, spot-on
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Emergency Medicine (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Insects & Arthropods (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SM20200632T 2011-09-12 2012-09-12 Composizioni antiparassitarie comprendenti un principio attivo isossazolinico, metodo e loro usi SMT202000632T1 (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161533308P 2011-09-12 2011-09-12
EP16187099.3A EP3172964B1 (en) 2011-09-12 2012-09-12 Parasiticidal compositions comprising an isoxazoline active agent, method and uses thereof

Publications (1)

Publication Number Publication Date
SMT202000632T1 true SMT202000632T1 (it) 2021-01-05

Family

ID=47018471

Family Applications (2)

Application Number Title Priority Date Filing Date
SM20200632T SMT202000632T1 (it) 2011-09-12 2012-09-12 Composizioni antiparassitarie comprendenti un principio attivo isossazolinico, metodo e loro usi
SM20190149T SMT201900149T1 (it) 2011-09-12 2012-09-12 Composizioni parassiticide comprendenti un agente attivo isossazolina, loro procedimenti e usi

Family Applications After (1)

Application Number Title Priority Date Filing Date
SM20190149T SMT201900149T1 (it) 2011-09-12 2012-09-12 Composizioni parassiticide comprendenti un agente attivo isossazolina, loro procedimenti e usi

Country Status (43)

Country Link
US (6) US9180121B2 (enExample)
EP (3) EP3788874A1 (enExample)
JP (3) JP6366102B2 (enExample)
KR (3) KR20200019793A (enExample)
CN (3) CN106943399B (enExample)
AP (1) AP2014007508A0 (enExample)
AR (3) AR087838A1 (enExample)
AU (5) AU2012308776B2 (enExample)
BR (2) BR112014005514B1 (enExample)
CA (1) CA2848317C (enExample)
CL (2) CL2014000601A1 (enExample)
CO (1) CO6910187A2 (enExample)
CR (2) CR20180572A (enExample)
CY (3) CY1121402T1 (enExample)
DK (2) DK3172964T3 (enExample)
EA (3) EA038853B1 (enExample)
ES (2) ES2834427T3 (enExample)
FR (1) FR21C1025I2 (enExample)
HR (2) HRP20190426T1 (enExample)
HU (3) HUE042360T2 (enExample)
IL (4) IL231358A (enExample)
IN (1) IN2014CN02128A (enExample)
LT (3) LT2755473T (enExample)
LU (1) LUC00211I2 (enExample)
MA (1) MA35431B1 (enExample)
ME (1) ME03347B (enExample)
MX (2) MX364978B (enExample)
MY (2) MY185280A (enExample)
NO (1) NO2021026I1 (enExample)
NZ (1) NZ725115A (enExample)
PE (1) PE20142292A1 (enExample)
PH (2) PH12014500537A1 (enExample)
PL (2) PL2755473T3 (enExample)
PT (2) PT3172964T (enExample)
RS (2) RS58417B1 (enExample)
SG (2) SG10201606670WA (enExample)
SI (2) SI3172964T1 (enExample)
SM (2) SMT202000632T1 (enExample)
TN (1) TN2014000105A1 (enExample)
TR (1) TR201903499T4 (enExample)
TW (2) TWI632135B (enExample)
WO (1) WO2013039948A1 (enExample)
ZA (1) ZA201401672B (enExample)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HK1197000A1 (en) 2011-07-13 2015-01-02 Clarke Mosquito Control Products, Inc Insecticidal compositions and methods of using the same
AR087838A1 (es) * 2011-09-12 2014-04-23 Merial Ltd Composiciones parasiticidas que comprenden un agente activo de isoxazolina, sus metodos y usos
NZ731588A (en) 2012-02-06 2018-11-30 Boehringer Ingelheim Animal Health Usa Inc Parasiticidal oral veterinary compositions comprising systemically-acting active agents, methods and uses thereof
BR112014024832B1 (pt) 2012-04-04 2022-05-31 Intervet International B.V. Método para a preparação de uma composição farmacêutica veterinária mastigável macia, composição farmacêutica, e, uso da composição
CN105451771B (zh) 2013-03-15 2020-05-19 阿根塔创新有限公司 可咀嚼配制物
EP3733664A1 (en) * 2013-11-01 2020-11-04 Boehringer Ingelheim Animal Health USA Inc. Antiparisitic and pesticidal isoxazoline compounds
PL3878281T3 (pl) 2013-12-20 2023-07-31 Intervet International B.V. Zastosowanie związków izoksazoliny u drobiu
HUE072822T2 (hu) * 2013-12-20 2025-12-28 Intervet Int B V Izoxazolin kompozíciók és azok felhasználása parazita fertõzések megelõzésében vagy kezelésében állatokban
GB2523811A (en) * 2014-03-06 2015-09-09 Norbrook Lab Ltd Novel Isoxazolines and their uses
CN104095871A (zh) * 2014-07-10 2014-10-15 青岛蔚蓝生物股份有限公司 一种含盐酸林可霉素与硫酸大观霉素的兽用注射液
WO2016022066A1 (en) 2014-08-04 2016-02-11 Jerry Tan Eye Surgery Pte Ltd Pharmaceutical compositions for demodex related blepharitis and eyelid crusting
PL4008329T3 (pl) * 2014-12-22 2025-11-17 Intervet International B.V. Związki izoksazoliny do zastosowania w leczeniu demodekozy
GB2551451B (en) * 2015-02-03 2020-05-27 Bimeda Finance S A R L A formulation for treatment of blowfly strike
UY36570A (es) * 2015-02-26 2016-10-31 Merial Inc Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas
KR102593069B1 (ko) 2015-04-08 2023-10-23 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 이속사졸린 활성제를 포함하는 서방형 주사 제형, 이의 방법 및 용도
WO2016207234A1 (en) 2015-06-23 2016-12-29 Intervet International B.V. Isoxazoline solution containing vitamin e for use with sanitized drinking water
UY37137A (es) 2016-02-24 2017-09-29 Merial Inc Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos
KR102197921B1 (ko) * 2016-04-26 2021-01-04 오르가노 코포레이션 수처리제 조성물 및 수처리 방법
US20170333305A1 (en) * 2016-05-23 2017-11-23 Microban Products Company Topical skin product having retention property
WO2018039508A1 (en) 2016-08-25 2018-03-01 Merial, Inc. Method for reducing unwanted effects in parasiticidal treatments
BR112019007605A2 (pt) 2016-10-14 2019-09-17 Boehringer Ingelheim Animal Health Usa Inc compostos pesticidas e parasiticidas de vinil isoxazolina
BR112019016699B1 (pt) 2017-02-13 2021-03-23 Clarke Mosquito Control Products, Inc. Composição de inseticida
US10662163B2 (en) * 2017-04-05 2020-05-26 Boehringer Ingelheim Animal Health USA Inc. Crystalline forms of (S)-afoxolaner
US10420109B2 (en) * 2017-04-13 2019-09-17 Futurewei Technologies, Inc. System and method for providing explicit feedback in communications systems with multi-point connectivity
JP2020530850A (ja) 2017-08-14 2020-10-29 ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド 殺有害生物および殺寄生生物ピラゾール−イソキサゾリン化合物
KR20250057155A (ko) * 2017-12-15 2025-04-28 타르서스 파마수티칼스, 아이엔씨. 안검염을 치료하기 위한 이속사졸린 구충제 제제 및 방법
AR113997A1 (es) 2017-12-21 2020-07-08 Intervet Int Bv Composiciones antiparasitarias para unción dorsal continua
RU2676326C1 (ru) * 2017-12-26 2018-12-28 Федеральное государственное бюджетное научное учреждение "Прикаспийский зональный научно-исследовательский ветеринарный институт" Комплексная антибактериально-противогельминтозная композиция для лечения сельскохозяйственных животных и птиц
TWI812673B (zh) * 2018-02-12 2023-08-21 美商富曼西公司 用於防治無脊椎害蟲之萘異噁唑啉化合物
GB201809374D0 (en) * 2018-06-07 2018-07-25 Fish Vet Group Norge As Treatment for removing ectoparasites from fish
US12502377B2 (en) 2019-04-04 2025-12-23 Tarsus Pharmaceuticals, Inc. Method of eradicating ticks that attach to humans using lotilaner formulations
WO2020252269A1 (en) * 2019-06-14 2020-12-17 Piedmont Animal Health Inc. Long-acting topical formulation and method of use thereof
AU2021278871A1 (en) 2020-05-28 2023-01-19 Boehringer Ingelheim Animal Health USA Inc. Bi-modal release intra-ruminal capsule device and methods of use thereof
CA3185969A1 (en) 2020-07-24 2022-01-27 Jean Marie Defauw Process for making an isoxazoline compound and intermediate thereof
WO2022118814A1 (ja) * 2020-12-01 2022-06-09 住友化学株式会社 液体農薬組成物
WO2022140728A1 (en) 2020-12-21 2022-06-30 Boehringer Ingelheim Animam Health Usa Inc. Parasiticidal collar comprising isoxazoline compounds
CN112755049A (zh) * 2021-02-05 2021-05-07 哈密市动物疫病预防控制中心 用于提高犬绦虫病粪便检测灵敏度的泻剂配方及制备方法
CN114042065B (zh) * 2021-11-26 2024-03-15 长沙拜特生物科技研究所有限公司 一种复方甲苯咪唑透皮溶液剂及其制备方法
JPWO2023167248A1 (enExample) * 2022-03-01 2023-09-07
US20250195551A1 (en) * 2022-03-22 2025-06-19 L4 Bio Llc Liquid formulations of ivermectin compositions and use in gelatin dosage forms
CN117122571A (zh) * 2022-05-20 2023-11-28 天津瑞普生物技术股份有限公司 一种抗寄生虫感染的口服药物制剂及其制备方法和应用
PE20242118A1 (es) * 2023-12-22 2024-10-28 Agrovet Market S A Composicion farmaceutica topica que comprende una asociacion de una isoxazolina con una lactona macrociclica y un derivado de pirazino-isoquinolina para el tratamiento de infestaciones parasitarias en animales menores
WO2025257633A1 (en) 2024-06-12 2025-12-18 Boehringer Ingelheim Vetmedica Gmbh Long-acting castor oil-containing injectable formulations and methods of use thereof

Family Cites Families (117)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6426333B1 (en) 1996-09-19 2002-07-30 Merial Spot-on formulations for combating parasites
FR2753377B1 (fr) 1996-09-19 1999-09-24 Rhone Merieux Nouvelle association parasiticide a base de 1-n-phenylpyra- zoles et de lactones macrocycliques endectocides
NL160809C (nl) 1970-05-15 1979-12-17 Duphar Int Res Werkwijze ter bereiding van benzoylureumverbindingen, alsmede werkwijze ter bereiding van insekticide prepara- ten op basis van benzoylureumverbindingen.
US3950360A (en) 1972-06-08 1976-04-13 Sankyo Company Limited Antibiotic substances
JPS4914624A (enExample) 1972-06-08 1974-02-08
US3818047A (en) 1972-08-07 1974-06-18 C Henrick Substituted pyrones
SE434277B (sv) 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
CH604517A5 (enExample) 1976-08-19 1978-09-15 Ciba Geigy Ag
US4134973A (en) 1977-04-11 1979-01-16 Merck & Co., Inc. Carbohydrate derivatives of milbemycin and processes therefor
US4199569A (en) 1977-10-03 1980-04-22 Merck & Co., Inc. Selective hydrogenation products of C-076 compounds and derivatives thereof
US4144352A (en) 1977-12-19 1979-03-13 Merck & Co., Inc. Milbemycin compounds as anthelmintic agents
US4203976A (en) 1978-08-02 1980-05-20 Merck & Co., Inc. Sugar derivatives of C-076 compounds
JPS57139012A (en) 1981-02-23 1982-08-27 Sankyo Co Ltd Anthelmintic composition
US4427663A (en) 1982-03-16 1984-01-24 Merck & Co., Inc. 4"-Keto-and 4"-amino-4"-deoxy avermectin compounds and substituted amino derivatives thereof
JPS59199673A (ja) 1983-04-25 1984-11-12 Sumitomo Chem Co Ltd 含窒素複素環化合物、その製造法およびそれを有効成分とする有害生物防除剤
IL76708A (en) 1984-10-18 1990-01-18 Ciba Geigy Ag Substituted n-benzoyl-n'-(2,5-dichloro-4(1,1,2,3,3,3-hexafluoropropyloxy)-phenyl)ureas,their preparation and pesticidal compositions containing them
DE3681465D1 (enExample) 1985-02-04 1991-10-24 Nihon Bayer Agrochem K.K., Tokio/Tokyo, Jp
DE3603799A1 (de) 1986-02-07 1987-08-13 Philips Patentverwaltung Stromspiegelschaltung
EP0237482A1 (de) 1986-03-06 1987-09-16 Ciba-Geigy Ag C(29)-Carbonyloxi-milbemycin-Derivate zur Bekämpfung von tier- und pflanzenparasitären Schädlingen
ATE89560T1 (de) 1986-03-25 1993-06-15 Sankyo Co Makrolid-derivate, ihre herstellung und ihre verwendung.
GB8613914D0 (en) 1986-06-07 1986-07-09 Coopers Animal Health Liquid formulations
ATE75745T1 (de) 1986-07-02 1992-05-15 Ciba Geigy Ag Pestizide.
US4855317A (en) 1987-03-06 1989-08-08 Ciba-Geigy Corporation Insecticides and parasiticides
US4871719A (en) 1987-03-24 1989-10-03 Ciba-Geigy Corporation Composition for controlling parasites in productive livestock
US4874749A (en) 1987-07-31 1989-10-17 Merck & Co., Inc. 4"-Deoxy-4-N-methylamino avermectin Bla/Blb
EP0319142B1 (en) 1987-11-03 1994-04-06 Beecham Group Plc Intermediates for the preparation of anthelmintic macrolide antibiotics
NZ232422A (en) 1989-02-16 1992-11-25 Merck & Co Inc 13-ketal milbemycin derivatives and parasiticides
IE904606A1 (en) 1989-12-21 1991-07-03 Beecham Group Plc Novel products
NZ247278A (en) 1991-02-12 1995-03-28 Ancare Distributors Veterinary anthelmintic drench comprising a suspension of praziquantel in a liquid carrier
WO1992022555A1 (en) 1991-06-17 1992-12-23 Beecham Group Plc Paraherquamide derivatives, precursor thereof, processes for their preparation, microorganism used and their use as antiparasitic agents
US5345377A (en) 1992-10-30 1994-09-06 Electric Power Research Institute, Inc. Harmonic controller for an active power line conditioner
GB9300883D0 (en) 1993-01-18 1993-03-10 Pfizer Ltd Antiparasitic agents
US5399582A (en) 1993-11-01 1995-03-21 Merck & Co., Inc. Antiparasitic agents
DE4405898A1 (de) * 1994-02-18 1995-08-24 Schering Ag Transdermale therapeutische Systeme enthaltend Sexualsteroide
AUPM969994A0 (en) 1994-11-28 1994-12-22 Virbac S.A. Equine anthelmintic formulations
US6221894B1 (en) 1995-03-20 2001-04-24 Merck & Co., Inc. Nodulisporic acid derivatives
US5962499A (en) 1995-03-20 1999-10-05 Merck & Co., Inc. Nodulisporic acid derivatives
TW334436B (en) 1995-07-21 1998-06-21 Upjohn Co Antiparasitic marcfortines and paraherquamides
FR2739255B1 (fr) 1995-09-29 1998-09-04 Rhone Merieux Composition antiparasitaire pour le traitement et la protection des animaux de compagnie
IE80657B1 (en) 1996-03-29 1998-11-04 Merial Sas Insecticidal combination to control mammal fleas in particular fleas on cats and dogs
US5885607A (en) 1996-03-29 1999-03-23 Rhone Merieux N-phenylpyrazole-based anti-flea and anti-tick external device for cats and dogs
FR2752525B1 (fr) 1996-08-20 2000-05-05 Rhone Merieux Procede de lutte contre les myiases des cheptels bovins et ovins et compositions pour la mise en oeuvre de ce procede
US6010710A (en) 1996-03-29 2000-01-04 Merial Direct pour-on skin solution for antiparasitic use in cattle and sheep
US6998131B2 (en) 1996-09-19 2006-02-14 Merial Limited Spot-on formulations for combating parasites
US6207647B1 (en) 1997-07-18 2001-03-27 Smithkline Beecham Corporation RatA
JPH1149669A (ja) * 1997-08-05 1999-02-23 Nitto Denko Corp 抗ウイルス剤含有テープ製剤
JP4237293B2 (ja) * 1998-05-19 2009-03-11 東光薬品工業株式会社 経皮吸収型貼付剤
US6174540B1 (en) 1998-09-14 2001-01-16 Merck & Co., Inc. Long acting injectable formulations containing hydrogenated caster oil
US6962691B1 (en) * 1999-05-20 2005-11-08 U & I Pharmaceuticals Ltd. Topical spray compositions
PE20011289A1 (es) 2000-04-07 2001-12-21 Upjohn Co Composiciones antihelminticas que comprenden lactonas macrociclicas y espirodioxepinoindoles
CA2311881C (en) 2000-06-16 2007-08-28 Gary O. Maupin Control of arthropods in rodents
US6399786B1 (en) 2000-07-14 2002-06-04 Merck & Co., Inc. Nonacyclic nodulisporic acid derivatives
TW200409760A (en) 2002-09-11 2004-06-16 Novartis Ag Organic compounds
US9265725B2 (en) * 2002-10-25 2016-02-23 Foamix Pharmaceuticals Ltd. Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
US7262214B2 (en) 2003-02-26 2007-08-28 Merial Limited 1-N-arylpyrazole derivatives in prevention of arthropod-borne and mosquito-borne diseases
JP2004269368A (ja) * 2003-03-05 2004-09-30 Ogawa & Co Ltd 冷感剤組成物および該冷感剤組成物を含有する冷感化粧料
AU2004228041B2 (en) 2003-04-04 2009-06-04 Boehringer Ingelheim Animal Health USA Inc. Topical anthelmintic veterinary formulations
JP4405765B2 (ja) * 2003-08-04 2010-01-27 大阪化成株式会社 屋内性防ダニ剤
WO2005034952A2 (en) 2003-10-07 2005-04-21 The Feinstein Institute For Medical Research Isoxazole and isothiazole compounds useful in the treatment of inflammation
US7531186B2 (en) 2003-12-17 2009-05-12 Merial Limited Topical formulations comprising 1-N-arylpyrazole derivatives and amitraz
BRPI0508140B1 (pt) 2004-03-05 2015-03-17 Nissan Chemical Ind Ltd Composto benzamida substituída por isoxazolina da fórmula (1); da fórmula (2) substituído por 3,5-bis (aril substituído); da fórmula (4) substituída por alquinibenzeno ou um sal do mesmo; "pesticida, agroquímico, inseticida, parasiticida contendo como ingrediente ativo um ou mais composto benzamida substituída por isoxazolina e sal do mesmo"
US20050232876A1 (en) * 2004-04-19 2005-10-20 Robin Lynn Minga Skin care compositions
TWI350728B (en) * 2004-10-08 2011-10-21 Wyeth Corp Amitraz compositions
MX2007014101A (es) * 2005-05-09 2009-02-13 Foamix Ltd Vehiculo espumable y composiciones farmaceuticas del mismo.
US20060293260A1 (en) 2005-05-24 2006-12-28 Wyeth Useful high load concentrate compositions for control of ecto-and endo-parasites
CA2621228C (en) 2005-09-02 2014-05-27 Nissan Chemical Industries, Ltd. Isoxazoline-substituted benzamide compound and pesticide
AU2006326449A1 (en) 2005-12-14 2007-06-21 E. I. Du Pont De Nemours And Company Isoxazolines for controlling invertebrate pests
TW200803740A (en) 2005-12-16 2008-01-16 Du Pont 5-aryl isoxazolines for controlling invertebrate pests
TWI412322B (zh) * 2005-12-30 2013-10-21 Du Pont 控制無脊椎害蟲之異唑啉
US8058303B2 (en) 2006-03-08 2011-11-15 Nihon Nohyaku Co, Ltd Pharmaceutical composition for external use
BRPI0707091B8 (pt) 2006-03-10 2018-02-14 Nissan Chemical Ind Ltd composto de isoxalina e benzaldoxima substituído ou um sal do mesmo; pesticida, agroquímico, endo- ou ecto-parasiticidapara mamíferos ou pássaros, inseticida e acaricida contendo como um ou mais ingredientes ativos selecionados a partir do composto de isoxalina substituído e o sal do mesmo
BRPI0710403A2 (pt) 2006-04-20 2011-08-09 Du Pont composto composição, composição de controle, de pulverização, de isca, dispositivo de armadilha, métodos de controle, métodos de proteção, semente tratada, composição de proteção
JP2008044880A (ja) 2006-08-15 2008-02-28 Bayer Cropscience Ag 殺虫性イソオキサゾリン類
US8475818B2 (en) 2006-09-01 2013-07-02 E. I. De Pont De Nemours And Company Local topical administration formulations containing indoxacarb
JP5005772B2 (ja) 2007-02-26 2012-08-22 エルジー・ケム・リミテッド 導電性積層体およびその製造方法
US8119671B2 (en) 2007-03-07 2012-02-21 Nissan Chemical Industries, Ltd. Isoxazoline-substituted benzamide compound and pest control agent
JP5256753B2 (ja) 2007-03-29 2013-08-07 住友化学株式会社 イソオキサゾリン化合物とその有害生物防除用途
WO2008122375A2 (en) 2007-04-10 2008-10-16 Bayer Cropscience Ag Insecticidal aryl isoxazoline derivatives
PT2155699E (pt) 2007-05-15 2015-11-12 Merial Inc Compostos de ariloazol-2-il-cianoetilamino, método de fabrico e método de utilização
CN101815706A (zh) * 2007-06-13 2010-08-25 杜邦公司 异*唑啉杀昆虫剂
ATE550648T1 (de) 2007-06-22 2012-04-15 Genera Istrazivanja D O O Adamts4 als blut-biomarker und therapeutisches ziel bei chronischem nierenversagen
TWI430995B (zh) * 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
DK2182945T3 (en) 2007-06-27 2015-11-16 Du Pont PROCEDURE TO COMBAT PESTS WITH ANIMALS
EP2172448A4 (en) 2007-06-29 2012-01-11 Nissan Chemical Ind Ltd SUBSTITUTED ISOXAZOLINE OR ENONOXINE COMPOUND AND PESTICIDES
US8440633B2 (en) 2007-06-29 2013-05-14 Ah Usa 42 Llc Anthelmintic combination
KR20100038118A (ko) 2007-07-31 2010-04-12 와이어쓰 엘엘씨 체내구충 국소 조성물
TWI556741B (zh) 2007-08-17 2016-11-11 英特威特國際股份有限公司 異唑啉組成物及其作為抗寄生蟲藥上的應用
TW200924647A (en) 2007-08-30 2009-06-16 Schering Plough Ltd Local topical administration formulations containing fipronil
US8318757B2 (en) 2007-09-10 2012-11-27 Nissan Chemical Industries, Ltd. Substituted isoxazoline compound and pest control agent
BRPI0816564B8 (pt) 2007-10-03 2022-12-06 Du Pont Composto, composição para proteger um animal de uma praga parasita invertebrada e método para proteger um animal de uma praga parasita invertebrada
US8597688B2 (en) 2008-07-09 2013-12-03 Basf Se Pesticidal mixtures comprising isoxazoline compounds II
EP2306837B2 (en) 2008-07-09 2023-10-25 Basf Se Pesticidal active mixtures comprising isoxazoline compounds i
DE102008034944B4 (de) * 2008-07-26 2017-03-16 Arivine Pharma Ag Mikroemulsion
CN102143960A (zh) 2008-09-04 2011-08-03 先正达参股股份有限公司 杀虫化合物
CA2741186C (en) 2008-10-21 2016-07-19 Merial Limited Thioamide compounds, method of making and method of using thereof
CA2747060A1 (en) 2008-12-18 2010-07-15 Novartis Ag Isoxazolines derivatives and their use as pesticide
US8633134B2 (en) 2008-12-23 2014-01-21 Basf Se Substituted amidine compounds for combating animal pests
US20110288089A1 (en) 2009-01-22 2011-11-24 Syngenta Crop Protection Llc Insecticidal compounds
BRPI1006543A2 (pt) 2009-04-01 2015-08-25 Basf Se "compostos de isoxazolina, composição agrícola, composição veterinária, uso de composto, método para o controle de pragas invertebradas, material de propagação de plantas e método para o tratamento, controle, prevenção ou proteção de animais contra infestação ou infecção por parasitas"
CN101940790B (zh) * 2009-07-01 2012-07-25 润和生物医药科技(汕头)有限公司 一种新型促渗剂组合物及其在透皮给药系统中的应用
TWI487486B (zh) 2009-12-01 2015-06-11 Syngenta Participations Ag 以異唑啉衍生物為主之殺蟲化合物
EP3560923B1 (en) * 2009-12-17 2021-05-05 Boehringer Ingelheim Animal Health USA Inc. Anti parasitic dihydroazole compounds and compositions comprising same
CN102762543B (zh) 2010-02-01 2016-03-09 巴斯夫欧洲公司 用于防除动物害虫的取代的酮型异*唑啉化合物和衍生物
US20130085064A1 (en) 2010-02-25 2013-04-04 Syngenta Crop Protection Llc Pesticidal mixtures containing isoxazoline derivatives and insecticide or nematoicidal biological agent
UA108641C2 (uk) 2010-04-02 2015-05-25 Паразитицидна композиція, яка містить чотири активних агенти, та спосіб її застосування
SI2576523T1 (sl) * 2010-05-27 2016-05-31 E.I. du Pont de Nemours and Company Chestnut Run Plaza 974 Center Road Kristalinične oblike 4-(5-(3-kloro-5-(trifluorometil)fenil)-4,5-dihidro 5-(trifluorometil)-3-izoksazolil)-N-(2-okso-2-((2,2,2-trifluoroetil) amino)etil)-1 naftalenkarboksamida
BR112012031088A8 (pt) 2010-06-09 2017-10-10 Syngenta Participations Ag Misturas pesticidas incluindo os derivados da isoxazolina
EP2579725A2 (en) 2010-06-09 2013-04-17 Syngenta Participations AG Pesticidal mixtures including isoxazoline derivatives
US20130261069A1 (en) 2010-06-09 2013-10-03 Syngenta Crop Protection Llc Pesticidal mixtures comprising isoxazoline derivatives
DK178277B1 (da) * 2010-06-18 2015-10-26 Novartis Tiergesundheit Ag Diaryloxazolinforbindelser til bekæmpelse af fiskelus
WO2012007426A1 (en) 2010-07-13 2012-01-19 Basf Se Azoline substituted isoxazoline benzamide compounds for combating animal pests
KR101508862B1 (ko) 2010-08-05 2015-04-07 조에티스 엘엘씨 구충제로서 이속사졸린 유도체
ES2793481T3 (es) 2010-09-24 2020-11-16 Zoetis Services Llc Oximas de isoxazolina como agentes antiparasitarios
MX348079B (es) 2010-12-27 2017-05-25 Intervet Int Bv Formulacion de isoxazolina topica localizada que comprende glucofurol.
NZ611476A (en) 2010-12-27 2015-10-30 Intervet Int Bv Topical localized isoxazoline formulation
AR087838A1 (es) * 2011-09-12 2014-04-23 Merial Ltd Composiciones parasiticidas que comprenden un agente activo de isoxazolina, sus metodos y usos
NZ731588A (en) * 2012-02-06 2018-11-30 Boehringer Ingelheim Animal Health Usa Inc Parasiticidal oral veterinary compositions comprising systemically-acting active agents, methods and uses thereof

Also Published As

Publication number Publication date
LTPA2021006I1 (enExample) 2021-07-12
SI2755473T1 (sl) 2019-03-29
CY1121402T1 (el) 2020-05-29
AU2019203419B2 (en) 2021-04-08
HUE042360T2 (hu) 2019-06-28
ZA201401672B (en) 2015-02-25
IL240283A (en) 2017-02-28
EP2755473A1 (en) 2014-07-23
CA2848317A1 (en) 2013-03-21
PH12018501647A1 (en) 2019-02-27
AR087838A1 (es) 2014-04-23
HRP20190426T1 (hr) 2019-04-19
CL2014000601A1 (es) 2014-10-10
CA2848317C (en) 2021-01-19
US20190216784A1 (en) 2019-07-18
LUC00211I2 (enExample) 2024-10-04
LTC3172964I2 (enExample) 2023-03-10
TW201702235A (zh) 2017-01-16
HK1232073A1 (en) 2018-01-05
CN106943399B (zh) 2020-07-28
NZ622466A (en) 2015-10-30
KR101968489B1 (ko) 2019-04-12
EP3172964A1 (en) 2017-05-31
MX2019003906A (es) 2019-12-09
HUS2100024I1 (hu) 2021-07-28
KR20190038681A (ko) 2019-04-08
US9180121B2 (en) 2015-11-10
EP2755473B1 (en) 2018-12-12
TN2014000105A1 (en) 2015-07-01
CN103957701B (zh) 2017-05-03
SI3172964T1 (sl) 2020-12-31
US10786487B2 (en) 2020-09-29
FR21C1025I1 (fr) 2021-08-06
RS61048B1 (sr) 2020-12-31
TWI632135B (zh) 2018-08-11
AR122776A2 (es) 2022-10-05
AU2017228622B2 (en) 2019-02-28
BR112014005514A2 (pt) 2017-03-21
EA201790094A1 (ru) 2017-05-31
EP3788874A1 (en) 2021-03-10
JP6946528B2 (ja) 2021-10-06
DK2755473T3 (en) 2019-03-11
LT2755473T (lt) 2019-03-12
CL2015000630A1 (es) 2015-07-17
SG11201400558YA (en) 2014-04-28
AU2016202105B2 (en) 2017-06-29
US20230087923A1 (en) 2023-03-23
WO2013039948A1 (en) 2013-03-21
TR201903499T4 (tr) 2019-04-22
AU2019203419A1 (en) 2019-06-06
KR20140061530A (ko) 2014-05-21
NZ742345A (en) 2020-05-29
US11464763B2 (en) 2022-10-11
FR21C1025I2 (fr) 2023-02-17
IL240283A0 (en) 2015-09-24
ES2834427T3 (es) 2021-06-17
AU2016202105A1 (en) 2016-04-28
CN106474120A (zh) 2017-03-08
US20170020849A1 (en) 2017-01-26
BR112014005514B1 (pt) 2019-12-03
IL231358A0 (en) 2014-04-30
SG10201606670WA (en) 2016-10-28
IL268295A (en) 2019-09-26
CY2021015I1 (el) 2021-10-15
EA026947B1 (ru) 2017-06-30
CY1123701T1 (el) 2021-09-14
US9877950B2 (en) 2018-01-30
JP2020203891A (ja) 2020-12-24
EA201892754A1 (ru) 2019-05-31
CY2021015I2 (el) 2021-10-15
CR20140117A (es) 2014-06-12
BR122019001738B1 (pt) 2019-11-05
CO6910187A2 (es) 2014-03-31
NZ725115A (en) 2018-08-31
LT3172964T (lt) 2020-12-10
NO2021026I1 (en) 2021-06-22
ME03347B (me) 2019-10-20
PT3172964T (pt) 2020-11-30
AU2012308776B2 (en) 2016-04-14
EP3172964B1 (en) 2020-08-26
IN2014CN02128A (enExample) 2015-05-29
RS58417B1 (sr) 2019-04-30
US10383854B2 (en) 2019-08-20
HUE052594T2 (hu) 2021-05-28
EA032162B1 (ru) 2019-04-30
US20160051519A1 (en) 2016-02-25
IL231358A (en) 2016-04-21
CR20180572A (es) 2019-02-01
EA201400340A1 (ru) 2014-08-29
MY198581A (en) 2023-09-06
AU2012308776A1 (en) 2014-04-03
IL268295B (en) 2020-06-30
TWI567064B (zh) 2017-01-21
US20130065846A1 (en) 2013-03-14
CN106474120B (zh) 2020-07-28
MX2014002904A (es) 2014-05-07
JP2018154660A (ja) 2018-10-04
PL2755473T3 (pl) 2019-05-31
ES2715000T3 (es) 2019-05-31
IL249830B (en) 2019-08-29
KR102081036B1 (ko) 2020-02-24
KR20200019793A (ko) 2020-02-24
CN106943399A (zh) 2017-07-14
AU2021204688A1 (en) 2021-07-29
AR117163A2 (es) 2021-07-14
JP2014527081A (ja) 2014-10-09
MA35431B1 (fr) 2014-09-01
US20210128533A1 (en) 2021-05-06
HRP20201745T1 (hr) 2020-12-25
AU2017228622A1 (en) 2017-10-05
PL3172964T3 (pl) 2021-03-08
SMT201900149T1 (it) 2019-05-10
MX364978B (es) 2019-05-16
PE20142292A1 (es) 2015-01-10
CN103957701A (zh) 2014-07-30
EA038853B1 (ru) 2021-10-28
PH12014500537A1 (en) 2014-04-21
DK3172964T3 (da) 2020-11-30
TW201317219A (zh) 2013-05-01
MY185280A (en) 2021-04-30
JP6366102B2 (ja) 2018-08-01
PT2755473T (pt) 2019-03-25
IL249830A0 (en) 2017-02-28
AP2014007508A0 (en) 2014-03-31

Similar Documents

Publication Publication Date Title
IL268295A (en) Parasiticidal preparations containing the active factor isoxazoline, methods and uses
IL249141A0 (en) Preparations for the treatment of parasites containing a large number of active factors, their methods and uses
GB2514951C (en) Parasiticidal oral veterinary compositions comprising systemically-acting active agents, methods and uses thereof