SMT201600166B - Processi per la produzione di un agente farmaceuticamente attivo - Google Patents
Processi per la produzione di un agente farmaceuticamente attivoInfo
- Publication number
- SMT201600166B SMT201600166B SM201600166T SM201600166T SMT201600166B SM T201600166 B SMT201600166 B SM T201600166B SM 201600166 T SM201600166 T SM 201600166T SM 201600166 T SM201600166 T SM 201600166T SM T201600166 B SMT201600166 B SM T201600166B
- Authority
- SM
- San Marino
- Prior art keywords
- processes
- production
- active agent
- pharmaceutically active
- pharmaceutically
- Prior art date
Links
- 239000013543 active substance Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28953009P | 2009-12-23 | 2009-12-23 | |
| PCT/DK2010/050348 WO2011076212A2 (en) | 2009-12-23 | 2010-12-20 | Processes for the manufacture of a pharmaceutically active agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SMT201600166B true SMT201600166B (it) | 2016-07-01 |
Family
ID=43567689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SM201600166T SMT201600166B (it) | 2009-12-23 | 2016-06-10 | Processi per la produzione di un agente farmaceuticamente attivo |
Country Status (37)
| Country | Link |
|---|---|
| US (3) | US8461353B2 (it) |
| EP (1) | EP2516394B1 (it) |
| JP (2) | JP5864435B2 (it) |
| KR (2) | KR101873182B1 (it) |
| CN (2) | CN103694161B (it) |
| AR (1) | AR079580A1 (it) |
| AU (1) | AU2010335659B2 (it) |
| BR (1) | BR112012015749A2 (it) |
| CA (1) | CA2785440C (it) |
| CL (1) | CL2012001725A1 (it) |
| CR (1) | CR20120316A (it) |
| CY (1) | CY1118032T1 (it) |
| DK (1) | DK2516394T3 (it) |
| DO (1) | DOP2012000170A (it) |
| EA (1) | EA021440B1 (it) |
| ES (1) | ES2575666T3 (it) |
| GE (1) | GEP20146078B (it) |
| HR (1) | HRP20160518T1 (it) |
| HU (1) | HUE028806T2 (it) |
| IL (2) | IL220329A (it) |
| MA (1) | MA33945B1 (it) |
| ME (1) | ME02401B (it) |
| MX (1) | MX2012007078A (it) |
| MY (1) | MY159251A (it) |
| NZ (2) | NZ625798A (it) |
| PH (1) | PH12012501258A1 (it) |
| PL (1) | PL2516394T3 (it) |
| PT (1) | PT2516394E (it) |
| RS (1) | RS54820B1 (it) |
| SG (1) | SG181910A1 (it) |
| SI (1) | SI2516394T1 (it) |
| SM (1) | SMT201600166B (it) |
| TN (1) | TN2012000279A1 (it) |
| TW (1) | TW201139370A (it) |
| UA (1) | UA111584C2 (it) |
| WO (1) | WO2011076212A2 (it) |
| ZA (1) | ZA201305936B (it) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201139370A (en) | 2009-12-23 | 2011-11-16 | Lundbeck & Co As H | Processes for the manufacture of a pharmaceutically active agent |
| JO3459B1 (ar) | 2012-09-09 | 2020-07-05 | H Lundbeck As | تركيبات صيدلانية لعلاج مرض الزهايمر |
| JO3639B1 (ar) * | 2014-07-04 | 2020-08-27 | H Lundbeck As | صورة متعددة الشكل جديدة لـ n-[2-(6-فلورو-1h-إندول-3-يل)إيثيل]-3-(2،2،3،3-تترا فلورو بروبوكسي)بنزيل أمين هيدروكلوريد |
| CN104130174A (zh) * | 2014-07-30 | 2014-11-05 | 天津市斯芬克司药物研发有限公司 | 一种吲唑衍生物及其制备方法 |
| CN105175307A (zh) * | 2014-11-18 | 2015-12-23 | 苏州晶云药物科技有限公司 | Lu AE58054的盐酸盐晶型A及其制备方法和用途 |
| CN104529865B (zh) * | 2014-12-12 | 2017-02-01 | 广东东阳光药业有限公司 | 苄胺类衍生物及其在药物上的应用 |
| MA41148A (fr) * | 2014-12-12 | 2017-10-17 | H Lundbeck As | Procédé de fabrication d'idalopirdine |
| US20160168089A1 (en) | 2014-12-12 | 2016-06-16 | H. Lundbeck A/S | Process for the manufacture of idalopirdine |
| WO2017067670A1 (en) | 2015-10-23 | 2017-04-27 | Pharmathen S.A. | A novel process for the preparation of tryptamines and derivatives thereof |
| CN108884034A (zh) * | 2016-04-08 | 2018-11-23 | H.隆德贝克有限公司 | 经由亚胺的氢化制造艾达鲁吡啶的方法 |
| EP3333154A1 (en) * | 2016-12-07 | 2018-06-13 | Sandoz Ag | Crystalline form of a selective 5-ht6 receptor antagonist |
| JP2022515610A (ja) * | 2018-12-27 | 2022-02-21 | エフ．ホフマン－ラ ロシュ アーゲー | ｅｘｏ－ｔｅｒｔ－ブチルＮ－（３－アザビシクロ［３．２．１］オクタン－８－イル）カルバミン酸塩の調製のためのプロセス |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3042685A (en) | 1962-07-03 | Process of making g-fluoro tryptamine | ||
| GB846675A (en) | 1958-04-18 | 1960-08-31 | Lab Francais Chimiotherapie | Process for the production of a tryptamine derivative |
| US4803218A (en) * | 1982-09-29 | 1989-02-07 | Mcneilab, Inc. | 3-aminoalkyl-1H-indole-5-urea and amide derivatives |
| JP2851439B2 (ja) | 1993-12-28 | 1999-01-27 | ローヌープーラン シミ | ニトリルを水素化してアミンにするための触媒の調製方法及びこの触媒の水素化における用途 |
| EP0737181B1 (fr) | 1993-12-28 | 1999-02-24 | RHODIA FIBER & RESIN INTERMEDIATES | Procede d'hydrogenation catalytique de nitriles en amines en presence d'un catalyseur de type nickel de raney dope |
| US5869653A (en) | 1997-10-30 | 1999-02-09 | Air Products And Chemicals, Inc. | Hydrogenation of nitriles to produce amines |
| JP2001508197A (ja) | 1997-10-31 | 2001-06-19 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 構成信号にノイズを加算してｌｐｃ原理により符号化された音声のオーディオ再生のための方法及び装置 |
| US6156694A (en) | 1998-11-05 | 2000-12-05 | E. I. Dupont De Nemours & Company | Raney cobalt catalyst and a process for hydrogenating organic compounds using said catalyst |
| CZ305838B6 (cs) * | 2001-03-29 | 2016-04-06 | Eli Lilly And Company | N-(2-arylethyl)benzylaminy jako antagonisté receptoru 5-HT6 |
| US7084154B2 (en) * | 2003-02-11 | 2006-08-01 | Pharmacopeia Drug Disclovery, Inc. | 2-(aminomethyl) arylamide analgesics |
| FR2866335B1 (fr) | 2004-02-13 | 2006-05-26 | Servier Lab | Nouveau procede de synthese de l'agomelatine |
| JP2006169113A (ja) * | 2004-12-10 | 2006-06-29 | Dainippon Sumitomo Pharma Co Ltd | インドール類の合成方法および合成中間体 |
| CA2633243C (en) * | 2005-12-15 | 2014-05-27 | Exelixis, Inc. | Azepinoindole derivatives as pharmaceutical agents |
| EP2002834A1 (de) * | 2007-06-13 | 2008-12-17 | Bayer Schering Pharma Aktiengesellschaft | Aryl/Hetarylamide als Modulatoren des EP2-Rezeptors |
| JO2704B1 (en) * | 2007-09-21 | 2013-03-03 | جانسين فارماسوتيكا ان في | Interference inhibition factors between MD2 and B53 |
| US8642660B2 (en) | 2007-12-21 | 2014-02-04 | The University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| WO2010036362A1 (en) | 2008-09-26 | 2010-04-01 | Wyeth | 1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate nuclear receptor inhibitors |
| CN101531624A (zh) | 2009-04-08 | 2009-09-16 | 大连凯飞精细化工有限公司 | 6-氟吲哚-3-乙腈的合成方法 |
| TW201139370A (en) | 2009-12-23 | 2011-11-16 | Lundbeck & Co As H | Processes for the manufacture of a pharmaceutically active agent |
-
2010
- 2010-12-16 TW TW099144129A patent/TW201139370A/zh unknown
- 2010-12-20 MA MA35092A patent/MA33945B1/fr unknown
- 2010-12-20 BR BR112012015749A patent/BR112012015749A2/pt active Search and Examination
- 2010-12-20 PL PL10803222.8T patent/PL2516394T3/pl unknown
- 2010-12-20 HR HRP20160518TT patent/HRP20160518T1/hr unknown
- 2010-12-20 HU HUE10803222A patent/HUE028806T2/en unknown
- 2010-12-20 RS RS20160382A patent/RS54820B1/sr unknown
- 2010-12-20 MY MYPI2012002675A patent/MY159251A/en unknown
- 2010-12-20 AU AU2010335659A patent/AU2010335659B2/en not_active Ceased
- 2010-12-20 GE GEAP201012807A patent/GEP20146078B/en unknown
- 2010-12-20 ME MEP-2016-105A patent/ME02401B/me unknown
- 2010-12-20 WO PCT/DK2010/050348 patent/WO2011076212A2/en not_active Ceased
- 2010-12-20 PT PT108032228T patent/PT2516394E/pt unknown
- 2010-12-20 KR KR1020177031907A patent/KR101873182B1/ko not_active Expired - Fee Related
- 2010-12-20 SG SG2012046793A patent/SG181910A1/en unknown
- 2010-12-20 EA EA201290552A patent/EA021440B1/ru not_active IP Right Cessation
- 2010-12-20 CN CN201410004542.6A patent/CN103694161B/zh not_active Expired - Fee Related
- 2010-12-20 ES ES10803222.8T patent/ES2575666T3/es active Active
- 2010-12-20 DK DK10803222.8T patent/DK2516394T3/en active
- 2010-12-20 NZ NZ625798A patent/NZ625798A/en not_active IP Right Cessation
- 2010-12-20 MX MX2012007078A patent/MX2012007078A/es active IP Right Grant
- 2010-12-20 PH PH1/2012/501258A patent/PH12012501258A1/en unknown
- 2010-12-20 US US12/972,559 patent/US8461353B2/en not_active Expired - Fee Related
- 2010-12-20 UA UAA201207977A patent/UA111584C2/uk unknown
- 2010-12-20 EP EP10803222.8A patent/EP2516394B1/en active Active
- 2010-12-20 JP JP2012545093A patent/JP5864435B2/ja not_active Expired - Fee Related
- 2010-12-20 CN CN201080058864.9A patent/CN102656146B/zh not_active Expired - Fee Related
- 2010-12-20 CA CA2785440A patent/CA2785440C/en not_active Expired - Fee Related
- 2010-12-20 NZ NZ600639A patent/NZ600639A/en not_active IP Right Cessation
- 2010-12-20 SI SI201031191A patent/SI2516394T1/sl unknown
- 2010-12-20 KR KR1020127016217A patent/KR101796330B1/ko not_active Expired - Fee Related
- 2010-12-21 AR ARP100104826A patent/AR079580A1/es active IP Right Grant
-
2012
- 2012-05-31 TN TNP2012000279A patent/TN2012000279A1/en unknown
- 2012-06-12 IL IL220329A patent/IL220329A/en not_active IP Right Cessation
- 2012-06-12 CR CR20120316A patent/CR20120316A/es unknown
- 2012-06-18 DO DO2012000170A patent/DOP2012000170A/es unknown
- 2012-06-22 CL CL2012001725A patent/CL2012001725A1/es unknown
-
2013
- 2013-05-02 US US13/875,623 patent/US8901318B2/en not_active Expired - Fee Related
- 2013-08-07 ZA ZA2013/05936A patent/ZA201305936B/en unknown
-
2014
- 2014-02-25 IL IL231141A patent/IL231141A/en not_active IP Right Cessation
- 2014-11-25 US US14/553,029 patent/US9382205B2/en not_active Expired - Fee Related
-
2015
- 2015-12-24 JP JP2015251874A patent/JP6195605B2/ja not_active Expired - Fee Related
-
2016
- 2016-06-02 CY CY20161100488T patent/CY1118032T1/el unknown
- 2016-06-10 SM SM201600166T patent/SMT201600166B/it unknown
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