ES2575666T3 - Proceso de fabricación de un agente farmacéuticamente activo - Google Patents

Proceso de fabricación de un agente farmacéuticamente activo Download PDF

Info

Publication number
ES2575666T3
ES2575666T3 ES10803222.8T ES10803222T ES2575666T3 ES 2575666 T3 ES2575666 T3 ES 2575666T3 ES 10803222 T ES10803222 T ES 10803222T ES 2575666 T3 ES2575666 T3 ES 2575666T3
Authority
ES
Spain
Prior art keywords
manufacturing process
active agent
pharmaceutically active
formula
hydrogenate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES10803222.8T
Other languages
English (en)
Inventor
Frans Therkelsen
Michael Harold Rock
Svend Treppendahl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Application granted granted Critical
Publication of ES2575666T3 publication Critical patent/ES2575666T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Un procedimiento para la preparación del compuesto de fórmula IV,**Fórmula** Fórmula IV que comprende las etapas de: (a) mezclar (6-fluoro-1H-indol-3-il)acetonitrilo, NH3 en agua y un catalizador de metal de transición en un disolvente alcohólico; y (b) hidrogenar la mezcla con H2.

Description

imagen1
imagen2
imagen3
imagen4
imagen5
imagen6
imagen7
imagen8
imagen9

Claims (1)

  1. imagen1
    imagen2
ES10803222.8T 2009-12-23 2010-12-20 Proceso de fabricación de un agente farmacéuticamente activo Active ES2575666T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28953009P 2009-12-23 2009-12-23
US289530P 2009-12-23
PCT/DK2010/050348 WO2011076212A2 (en) 2009-12-23 2010-12-20 Processes for the manufacture of a pharmaceutically active agent

Publications (1)

Publication Number Publication Date
ES2575666T3 true ES2575666T3 (es) 2016-06-30

Family

ID=43567689

Family Applications (1)

Application Number Title Priority Date Filing Date
ES10803222.8T Active ES2575666T3 (es) 2009-12-23 2010-12-20 Proceso de fabricación de un agente farmacéuticamente activo

Country Status (37)

Country Link
US (3) US8461353B2 (es)
EP (1) EP2516394B1 (es)
JP (2) JP5864435B2 (es)
KR (2) KR101796330B1 (es)
CN (2) CN103694161B (es)
AR (1) AR079580A1 (es)
AU (1) AU2010335659B2 (es)
BR (1) BR112012015749A2 (es)
CA (1) CA2785440C (es)
CL (1) CL2012001725A1 (es)
CR (1) CR20120316A (es)
CY (1) CY1118032T1 (es)
DK (1) DK2516394T3 (es)
DO (1) DOP2012000170A (es)
EA (1) EA021440B1 (es)
ES (1) ES2575666T3 (es)
GE (1) GEP20146078B (es)
HR (1) HRP20160518T1 (es)
HU (1) HUE028806T2 (es)
IL (2) IL220329A (es)
MA (1) MA33945B1 (es)
ME (1) ME02401B (es)
MX (1) MX2012007078A (es)
MY (1) MY159251A (es)
NZ (2) NZ625798A (es)
PH (1) PH12012501258A1 (es)
PL (1) PL2516394T3 (es)
PT (1) PT2516394E (es)
RS (1) RS54820B1 (es)
SG (1) SG181910A1 (es)
SI (1) SI2516394T1 (es)
SM (1) SMT201600166B (es)
TN (1) TN2012000279A1 (es)
TW (1) TW201139370A (es)
UA (1) UA111584C2 (es)
WO (1) WO2011076212A2 (es)
ZA (1) ZA201305936B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201139370A (en) 2009-12-23 2011-11-16 Lundbeck & Co As H Processes for the manufacture of a pharmaceutically active agent
JO3459B1 (ar) 2012-09-09 2020-07-05 H Lundbeck As تركيبات صيدلانية لعلاج مرض الزهايمر
JO3639B1 (ar) * 2014-07-04 2020-08-27 H Lundbeck As صورة متعددة الشكل جديدة لـ n-[2-(6-فلورو-1h-إندول-3-يل)إيثيل]-3-(2،2،3،3-تترا فلورو بروبوكسي)بنزيل أمين هيدروكلوريد
CN104130174A (zh) * 2014-07-30 2014-11-05 天津市斯芬克司药物研发有限公司 一种吲唑衍生物及其制备方法
CN105175307A (zh) * 2014-11-18 2015-12-23 苏州晶云药物科技有限公司 Lu AE58054的盐酸盐晶型A及其制备方法和用途
CN104529865B (zh) * 2014-12-12 2017-02-01 广东东阳光药业有限公司 苄胺类衍生物及其在药物上的应用
MA41148A (fr) * 2014-12-12 2017-10-17 H Lundbeck As Procédé de fabrication d'idalopirdine
SG11201704523WA (en) 2014-12-12 2017-07-28 H Lundbeck As A process for the manufacture of idalopirdine
WO2017067670A1 (en) 2015-10-23 2017-04-27 Pharmathen S.A. A novel process for the preparation of tryptamines and derivatives thereof
JP2019513742A (ja) * 2016-04-08 2019-05-30 ハー・ルンドベック・アクチエゼルスカベット イミンの水素化によるイダロピルジンの製造方法
EP3333154A1 (en) * 2016-12-07 2018-06-13 Sandoz Ag Crystalline form of a selective 5-ht6 receptor antagonist
US12275709B2 (en) * 2018-12-27 2025-04-15 Hoffmann-La Roche Inc. Process for the preparation of exo-tert-butyl N-(3-azabicyclo[3.2.1]octan-8-yl)carbamate

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3042685A (en) 1962-07-03 Process of making g-fluoro tryptamine
GB846675A (en) * 1958-04-18 1960-08-31 Lab Francais Chimiotherapie Process for the production of a tryptamine derivative
US4803218A (en) * 1982-09-29 1989-02-07 Mcneilab, Inc. 3-aminoalkyl-1H-indole-5-urea and amide derivatives
SG47042A1 (en) 1993-12-28 1998-03-20 Rhone Poulenc Chimie Process for the preparation of a catalyst for the hydrogenation of nitriles to amines and use of this catalyst in hydrogenation
BR9408460A (pt) 1993-12-28 1997-08-05 Rhone Poulenc Chimie Processo de hidrogenação catalítica de nitrilas em aminas com o auxílio de um catalisador do tipo níquel de raney
US5869653A (en) 1997-10-30 1999-02-09 Air Products And Chemicals, Inc. Hydrogenation of nitriles to produce amines
WO1999022561A2 (en) 1997-10-31 1999-05-14 Koninklijke Philips Electronics N.V. A method and apparatus for audio representation of speech that has been encoded according to the lpc principle, through adding noise to constituent signals therein
US6156694A (en) 1998-11-05 2000-12-05 E. I. Dupont De Nemours & Company Raney cobalt catalyst and a process for hydrogenating organic compounds using said catalyst
EP1379239B1 (en) * 2001-03-29 2007-09-12 Eli Lilly And Company N-(2-arylethyl) benzylamines as antagonists of the 5-ht6 receptor
US7084154B2 (en) * 2003-02-11 2006-08-01 Pharmacopeia Drug Disclovery, Inc. 2-(aminomethyl) arylamide analgesics
FR2866335B1 (fr) 2004-02-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'agomelatine
JP2006169113A (ja) * 2004-12-10 2006-06-29 Dainippon Sumitomo Pharma Co Ltd インドール類の合成方法および合成中間体
AU2006325815B2 (en) * 2005-12-15 2012-07-05 Exelixis, Inc. Azepinoindole derivatives as pharmaceutical agents
EP2002834A1 (de) * 2007-06-13 2008-12-17 Bayer Schering Pharma Aktiengesellschaft Aryl/Hetarylamide als Modulatoren des EP2-Rezeptors
JO2704B1 (en) * 2007-09-21 2013-03-03 جانسين فارماسوتيكا ان في Interference inhibition factors between MD2 and B53
JP2011507910A (ja) 2007-12-21 2011-03-10 ユニバーシティー オブ ロチェスター 真核生物の寿命を変更するための方法
CA2736880A1 (en) * 2008-09-26 2010-04-01 Wyeth Llc 1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate nuclear receptor inhibitors
CN101531624A (zh) * 2009-04-08 2009-09-16 大连凯飞精细化工有限公司 6-氟吲哚-3-乙腈的合成方法
TW201139370A (en) 2009-12-23 2011-11-16 Lundbeck & Co As H Processes for the manufacture of a pharmaceutically active agent

Also Published As

Publication number Publication date
US20150080584A1 (en) 2015-03-19
AU2010335659A1 (en) 2012-07-05
CY1118032T1 (el) 2017-05-17
CN103694161A (zh) 2014-04-02
CR20120316A (es) 2012-08-16
KR20120112480A (ko) 2012-10-11
BR112012015749A2 (pt) 2015-09-15
US20130245281A1 (en) 2013-09-19
NZ625798A (en) 2014-10-31
ZA201305936B (en) 2015-09-30
AU2010335659B2 (en) 2015-05-21
US8901318B2 (en) 2014-12-02
IL220329A (en) 2016-03-31
AR079580A1 (es) 2012-02-01
US20110152539A1 (en) 2011-06-23
MA33945B1 (fr) 2013-01-02
CN102656146A (zh) 2012-09-05
KR20170125417A (ko) 2017-11-14
CA2785440A1 (en) 2011-06-30
KR101873182B1 (ko) 2018-06-29
HK1196352A1 (en) 2014-12-12
PH12012501258A1 (en) 2013-02-04
MX2012007078A (es) 2012-07-20
IL231141A0 (en) 2014-03-31
CN103694161B (zh) 2015-09-09
JP2013515683A (ja) 2013-05-09
HRP20160518T1 (hr) 2016-06-03
UA111584C2 (uk) 2016-05-25
DOP2012000170A (es) 2012-08-31
ME02401B (me) 2016-09-20
KR101796330B1 (ko) 2017-11-09
GEP20146078B (en) 2014-04-10
MY159251A (en) 2016-12-30
JP6195605B2 (ja) 2017-09-13
IL231141A (en) 2016-03-31
SMT201600166B (it) 2016-07-01
WO2011076212A3 (en) 2011-08-11
US9382205B2 (en) 2016-07-05
RS54820B1 (sr) 2016-10-31
HUE028806T2 (en) 2017-01-30
IL220329A0 (en) 2012-08-30
PT2516394E (pt) 2016-06-07
JP5864435B2 (ja) 2016-02-17
JP2016117734A (ja) 2016-06-30
DK2516394T3 (en) 2016-06-13
US8461353B2 (en) 2013-06-11
CN102656146B (zh) 2014-12-17
CA2785440C (en) 2018-05-01
CL2012001725A1 (es) 2012-11-30
TN2012000279A1 (en) 2013-12-12
HK1174921A1 (en) 2013-06-21
EA201290552A1 (ru) 2012-12-28
SG181910A1 (en) 2012-08-30
EP2516394A2 (en) 2012-10-31
EP2516394B1 (en) 2016-03-16
NZ600639A (en) 2014-07-25
TW201139370A (en) 2011-11-16
PL2516394T3 (pl) 2016-09-30
WO2011076212A2 (en) 2011-06-30
SI2516394T1 (sl) 2016-07-29
EA021440B1 (ru) 2015-06-30

Similar Documents

Publication Publication Date Title
ES2575666T3 (es) Proceso de fabricación de un agente farmacéuticamente activo
CL2009000393A1 (es) Composición farmaceutica que comprende a) un agente farmaceutico activable, b) un agente activo plasmonico; util para el tratamiento de trastornos de proliferación celular.
ES2525918T3 (es) Proceso para la fabricación de Nicorandil
AR062059A1 (es) Espuma farmaceutica con acido graso
EA200901563A1 (ru) Новый способ синтеза ивабрадина и его солей присоединения с фармацевтически приемлемой кислотой
BRPI1006162A2 (pt) "composto,processo para preparar um composto,formulação farmacêutica,e uso de um composto".
CO6270303A2 (es) Producto de dispersion solida que contiene un compuesto a base de n-aril urea
CL2009002073A1 (es) Composicion farmaceutica solida para la liberacion controlada de un agente activo activo en el tracto gastrointestinal que comprende al menos un agente acido con solubilidad de menos de 0,3 mg/ml en solucion acuosa a un ph alrededor del pka del agente acido, un polimero hidrofilo, un alcanizador; uso en trastornos cardiovasculares.
CO6341578A2 (es) Síntesis de estirilpiridinas radiomarcadas con 18f a partir de precursores de tosilato y composiciones farmacéuticas estables de estas
PE20142371A1 (es) Combinacion farmaceutica de 3-(3-dimetilamino-1-etil-2-metil-propil)-fenol y un antiepileptico
MX2019012598A (es) Metodo para formulacion de farmaco basado en el aumento de la afinidad de agentes activos hacia las superficies de microparticulas cristalinas.
CL2013001876A1 (es) Compuesto para la modificación reversible de una poliamina activa en membrana anfifática; polímero de suministro para suministrar un polinecleotido de interferencia de arn (iarn) a una célula in vivo; uso de un iarn con un polimero de suministro.
GB2481775A (en) Thinning agent
CL2011000166A1 (es) Metodo para preparar tetrahidrobiopterina hidrolizando diacetilbiopterina a biopterina en presencia de una base en una mezcla bifasica de agua y solvente organico no miscible en agua e hidrogenando biopterina a tetrahidrobiopterina en presencia de un catalizador, ambas etapas a un ph de al menos 10 (divisional de la solicitud de patente de invencion no. 7-2009).
CL2012000374A1 (es) Metodo para la preparacion de una composicion saborizante activa que comprende una primera reaccion entre un compuesto amino y un carbonilo, resultando una primera mezcla de intermediarios, una segunda reaccion con un segundo compuesto amino solo o en combinacion con un compuesto carbinilo, resultando una segunda mezcla de intermediarios, reacciones serparadas adicionales con compuestos de otras clases quimicas, ultima reaccion que comprende una mezcla de todas las mezclas de intermediarios anteriores.
BR112013026422A2 (pt) coluna telescópica que pode ser calibrada, peça de mobília que tem uma coluna telescópica que pode ser calibrada e método para calibrar uma coluna telescópica
ES2555778T3 (es) Mejora de la biodisponibilidad de principios activos con función amidina en medicamentos
ES2542733B1 (es) Brazo de Soporte para reflector conformado
BR112012014621A2 (pt) processo para a preparação de compostos de quelato
TR201904884T4 (tr) Koloni̇k boşaltmada kullanima yöneli̇k formülasyonlar ve formülasyonlarin üreti̇m yöntemleri̇
EA201000398A1 (ru) Новый способ синтеза ивабрадина и его солей присоединения с фармацевтически приемлемой кислотой
AR081732A1 (es) Composicion de control de fitoenfermedades y metodo para controlar fitoenfermedades
ES2561813T3 (es) Aplicación tópica de nimesulida y tiocolchicósido
EA201301136A3 (ru) Новый способ синтеза (2e)-3-(3,4-диметоксифенил)проп-2-еннитрила, применение в синтезе ивабрадина и его фармацевтически приемлемых кислотно-аддитивных солей
EA201100132A1 (ru) Единичная доза ападеносона