SK95695A3 - 4-hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl £b| pyran- -2-ones useful to treat retroviral infections - Google Patents

4-hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl £b| pyran- -2-ones useful to treat retroviral infections Download PDF

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Publication number
SK95695A3
SK95695A3 SK956-95A SK95695A SK95695A3 SK 95695 A3 SK95695 A3 SK 95695A3 SK 95695 A SK95695 A SK 95695A SK 95695 A3 SK95695 A3 SK 95695A3
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SK
Slovakia
Prior art keywords
hydroxy
pyran
phenyl
hexahydro
cycloocta
Prior art date
Application number
SK956-95A
Other languages
English (en)
Slovak (sk)
Inventor
David J Anderson
S Lee Banitt
Paul Kosta Tomich
Michael J Bohanon
Steven R Turner
Joseph W Strohbach
Suvit Thaisrivongs
Chih-Ping Yang
Richard C Thomas
Karen R Romines
Paul A Aristoff
Harvey I Skulnick
Paul D Johnson
Ronald B Gammill
Qingwei Zhang
Gordon L Bundy
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of SK95695A3 publication Critical patent/SK95695A3/sk

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
    • C07D311/56—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/74—Benzo[b]pyrans, hydrogenated in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SK956-95A 1993-02-05 1994-02-03 4-hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl £b| pyran- -2-ones useful to treat retroviral infections SK95695A3 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US1445993A 1993-02-05 1993-02-05
US6871593A 1993-05-27 1993-05-27
US16930293A 1993-12-17 1993-12-17
PCT/US1994/000938 WO1994018188A1 (en) 1993-02-05 1994-02-03 4-hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl[b]pyran-2-ones useful to treat retroviral infections

Publications (1)

Publication Number Publication Date
SK95695A3 true SK95695A3 (en) 1995-12-06

Family

ID=27360109

Family Applications (1)

Application Number Title Priority Date Filing Date
SK956-95A SK95695A3 (en) 1993-02-05 1994-02-03 4-hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl £b| pyran- -2-ones useful to treat retroviral infections

Country Status (22)

Country Link
US (1) US5686486A (zh)
EP (1) EP0682663B1 (zh)
JP (2) JPH08505641A (zh)
CN (1) CN1117291A (zh)
AT (1) ATE200669T1 (zh)
AU (1) AU6166194A (zh)
CA (1) CA2153237A1 (zh)
CZ (1) CZ9502002A3 (zh)
DE (1) DE69427120T2 (zh)
DK (1) DK0682663T3 (zh)
FI (1) FI953717A0 (zh)
GR (1) GR3036189T3 (zh)
HU (1) HUT72755A (zh)
IL (1) IL108459A0 (zh)
LV (1) LV12863B (zh)
NO (1) NO953070L (zh)
NZ (1) NZ262255A (zh)
PL (1) PL310111A1 (zh)
PT (1) PT682663E (zh)
RU (1) RU2125999C1 (zh)
SK (1) SK95695A3 (zh)
WO (1) WO1994018188A1 (zh)

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HUT75225A (en) * 1993-11-19 1997-04-28 Parke Davis & Co 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents
US5808062A (en) * 1993-11-19 1998-09-15 Warner-Lambert Company Pyrone derivatives as protease inhibitors and antiviral agents
US5504104A (en) * 1993-11-19 1996-04-02 Warner-Lambert Company Tricyclic pyrone derivatives as protease inhibitors and antiviral agents
US6319929B1 (en) 1994-04-29 2001-11-20 The University Of North Carolina At Chapel Hill Suksdorfin analogs, compositions thereof, and methods for making and using thereof
IL129871A (en) * 1994-05-06 2003-11-23 Pharmacia & Upjohn Inc Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections
ES2191095T3 (es) * 1995-03-20 2003-09-01 Upjohn Co Acidos tetronicos sustituidos utiles contra el vih y otros retrovirus.
US6037157A (en) 1995-06-29 2000-03-14 Abbott Laboratories Method for improving pharmacokinetics
WO1997035565A1 (fr) * 1996-03-27 1997-10-02 Toray Industries, Inc. Derives de cetone et usage medicinal
WO1998045246A1 (fr) * 1997-04-04 1998-10-15 Teijin Limited Derives d'esters salicyliques et leur procede de preparation
ATE321035T1 (de) * 1997-09-26 2006-04-15 Toray Industries Zyklische ketonderivate und ihre pharmazeutische verwendung
US7145020B2 (en) * 2001-04-24 2006-12-05 Aryx Therapeutics Materials and methods for treating coagulation disorders
DK1383756T3 (da) * 2001-04-24 2008-06-23 Aryx Therapeutics Cumarinderivater til anvendelse som antikoagulanter
US7018642B2 (en) * 2001-04-27 2006-03-28 The Procter & Gamble Company Compounds, compositions, and methods for controlling biofilms
US7202928B2 (en) * 2003-10-16 2007-04-10 Lg. Philips Lcd Co., Ltd Array substrate for in-plane switching mode liquid crystal display device and method of fabricating the same
EP2161261B1 (en) * 2004-04-08 2013-08-28 Armetheon, Inc. Materials and methods for treating coagulation disorders
KR101203124B1 (ko) * 2004-04-08 2012-11-20 아메데온, 인코포레이티드 응고 장애 치료용 물질 및 치료 방법
MXPA06011637A (es) 2004-04-08 2007-05-04 Aryx Therapeutics Materiales y metodos para el tratamiento de trastornos de la coagulacion.
AR059339A1 (es) 2006-02-09 2008-03-26 Chugai Pharmaceutical Co Ltd Derivados de la cumarina para trastornos proliferativos de celulas, composicion farmaceutica y agente terapeutico que los contiene
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ATE541841T1 (de) * 2007-11-15 2012-02-15 Boehringer Ingelheim Int Inhibitoren der replikation des human immunodeficiency virus
EP2220046B1 (en) * 2007-11-16 2014-06-18 Gilead Sciences, Inc. Inhibitors of human immunodeficiency virus replication
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CN102040592B (zh) * 2009-10-10 2015-07-15 西南大学 具有抗微生物活性的香豆素唑类化合物、制备方法和医药用途
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JP6759100B2 (ja) * 2013-12-30 2020-09-23 ライフサイ ファーマシューティカルズ，インク． 治療用阻害化合物
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CN104374858B (zh) * 2014-11-21 2016-06-29 宜昌人福药业有限责任公司 一种枸橼酸舒芬太尼合成原料及杂质的检测方法
CN105218530B (zh) * 2015-10-20 2019-07-02 青岛农业大学 3-(1-芳基-2-(2-氮杂芳烃)乙基)-4-羟基香豆素及其制备方法
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Also Published As

Publication number Publication date
FI953717A (fi) 1995-08-04
RU2125999C1 (ru) 1999-02-10
PL310111A1 (en) 1995-11-27
ATE200669T1 (de) 2001-05-15
DE69427120D1 (de) 2001-05-23
NO953070L (no) 1995-10-04
JPH08505641A (ja) 1996-06-18
HU9501968D0 (en) 1995-09-28
CN1117291A (zh) 1996-02-21
IL108459A0 (en) 1994-04-12
DE69427120T2 (de) 2001-08-23
AU6166194A (en) 1994-08-29
CA2153237A1 (en) 1994-08-18
EP0682663A1 (en) 1995-11-22
NO953070D0 (no) 1995-08-04
DK0682663T3 (da) 2001-06-18
PT682663E (pt) 2001-10-30
CZ9502002A3 (en) 1995-12-13
NZ262255A (en) 1997-05-26
FI953717A0 (fi) 1995-08-04
GR3036189T3 (en) 2001-10-31
LV12863B (en) 2002-11-20
WO1994018188A1 (en) 1994-08-18
HUT72755A (en) 1996-05-28
US5686486A (en) 1997-11-11
JP2005002133A (ja) 2005-01-06
EP0682663B1 (en) 2001-04-18

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