SK8642002A3 - Farnesyl transferase inhibitors, process for their preparation and pharmaceutical compositions containing them - Google Patents
Farnesyl transferase inhibitors, process for their preparation and pharmaceutical compositions containing them Download PDFInfo
- Publication number
- SK8642002A3 SK8642002A3 SK864-2002A SK8642002A SK8642002A3 SK 8642002 A3 SK8642002 A3 SK 8642002A3 SK 8642002 A SK8642002 A SK 8642002A SK 8642002 A3 SK8642002 A3 SK 8642002A3
- Authority
- SK
- Slovakia
- Prior art keywords
- compound
- formula
- optionally substituted
- ester
- carbon atoms
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9930318.2A GB9930318D0 (en) | 1999-12-22 | 1999-12-22 | Novel compounds |
| PCT/GB2000/004856 WO2001046137A1 (fr) | 1999-12-22 | 2000-12-18 | Inhibiteurs de farnesyltransferase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK8642002A3 true SK8642002A3 (en) | 2002-12-03 |
Family
ID=10866834
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK864-2002A SK8642002A3 (en) | 1999-12-22 | 2000-12-18 | Farnesyl transferase inhibitors, process for their preparation and pharmaceutical compositions containing them |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US7101897B2 (fr) |
| EP (1) | EP1255733B1 (fr) |
| JP (1) | JP3742593B2 (fr) |
| KR (1) | KR20020063251A (fr) |
| CN (2) | CN1680313A (fr) |
| AR (1) | AR029460A1 (fr) |
| AT (1) | ATE316074T1 (fr) |
| AU (1) | AU776003B2 (fr) |
| BR (1) | BR0016669A (fr) |
| CA (1) | CA2387579A1 (fr) |
| CO (1) | CO5360641A1 (fr) |
| CZ (1) | CZ20022125A3 (fr) |
| DE (1) | DE60025650D1 (fr) |
| EE (1) | EE200200206A (fr) |
| GB (1) | GB9930318D0 (fr) |
| HU (1) | HUP0204135A3 (fr) |
| IL (1) | IL149871A0 (fr) |
| IS (1) | IS6358A (fr) |
| MX (1) | MXPA02005981A (fr) |
| MY (1) | MY133606A (fr) |
| NO (1) | NO20022924L (fr) |
| NZ (1) | NZ518341A (fr) |
| PL (1) | PL355887A1 (fr) |
| RU (1) | RU2259997C2 (fr) |
| SK (1) | SK8642002A3 (fr) |
| WO (1) | WO2001046137A1 (fr) |
| ZA (1) | ZA200202694B (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005117864A1 (fr) * | 2004-05-28 | 2005-12-15 | Astrazeneca Ab | Produit combine comprenant de l'anastrozole et un inhibiteur double de la prenyl transferase |
| JP4880473B2 (ja) * | 2004-10-08 | 2012-02-22 | 壽製薬株式会社 | ホスホン酸誘導体及び血中の高リン酸が関与する疾患の治療剤 |
| US20110136867A1 (en) * | 2006-02-02 | 2011-06-09 | Justman Craig J | Treatment of Synucleinopathies |
| WO2009151683A2 (fr) | 2008-03-12 | 2009-12-17 | Link Medicine Corporation | Inhibiteurs de quinolinone farnésyl transférase pour le traitement de synucléinopathies et d'autres indications |
| BRPI0920927A2 (pt) | 2008-11-13 | 2019-09-24 | Link Medicine Corp | derivados de azaquinolinona e usos dos mesmos |
| CN102448458B (zh) | 2009-03-18 | 2015-07-22 | 小利兰·斯坦福大学理事会 | 治疗黄病毒科病毒感染的方法和组合物 |
| WO2011088126A2 (fr) * | 2010-01-13 | 2011-07-21 | Eiger Biopharmaceuticals, Inc. | Traitement d'une infection virale avec des inhibiteurs de prényltransférase |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1283906C (fr) | 1983-05-09 | 1991-05-07 | Makoto Sunagawa | COMPOSE DE .beta.-LACTAM ET PROCEDE DE PRODUCTION |
| JPS60233076A (ja) | 1984-05-03 | 1985-11-19 | Sumitomo Chem Co Ltd | 新規なβ−ラクタム化合物およびその製造法 |
| DE3579888D1 (de) | 1984-11-08 | 1990-10-31 | Sumitomo Pharma | Carbapenemverbindungen und deren herstellung. |
| KR880006244A (ko) | 1986-11-24 | 1988-07-22 | 후지사와 도모 기찌 로 | 3-피롤리디닐티오-1-아자바이스클로[3.2.0]햅트2-엔-2-카르복실산 화합물 및 이의 제조방법 |
| GB8921635D0 (en) | 1989-09-25 | 1989-11-08 | Fujisawa Pharmaceutical Co | 3-pyrrolidinylthio-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid derivatives |
| CA2036163C (fr) | 1990-02-14 | 2001-06-19 | Makoto Sunagawa | Nouveaux composes de beta-lactame et leur production |
| IE910606A1 (en) | 1990-02-23 | 1991-08-28 | Sankyo Co | Carbapenem derivatives having antibiotic activity, their¹preparation and their use |
| GB9107363D0 (en) | 1991-04-08 | 1991-05-22 | Ici Plc | Antibiotic compounds |
| US6083917A (en) | 1990-04-18 | 2000-07-04 | Board Of Regents, The University Of Texas System | Methods and compositions for the identification, characterization and inhibition of farnesyltransferase |
| US5185248A (en) | 1990-05-08 | 1993-02-09 | E. R. Squibb & Sons, Inc. | Farnesyl-protein transferase assay for identifying compounds that block neoplastic transformation |
| JPH0578360A (ja) | 1991-01-31 | 1993-03-30 | Banyu Pharmaceut Co Ltd | ２−［２−（スルフアモイルアルキル）ピロリジニルチオカルバペネム誘導体 |
| GB9107341D0 (en) | 1991-04-08 | 1991-05-22 | Ici Plc | Antibiotic compounds |
| GB9107342D0 (en) | 1991-04-08 | 1991-05-22 | Ici Plc | Antibiotic compounds |
| JP2559949B2 (ja) | 1991-06-04 | 1996-12-04 | 三共株式会社 | １−メチルカルバペネム誘導体 |
| JPH04368386A (ja) | 1991-06-18 | 1992-12-21 | Sankyo Co Ltd | １−メチルカルバペネム−３−カルボン酸の製造法 |
| US5360798A (en) | 1991-07-04 | 1994-11-01 | Shionogi Seiyaku Kabushiki Kaisha | Aminooxypyrrolidinylthiocarbapenem compounds |
| ES2075630T3 (es) | 1991-10-11 | 1995-10-01 | Squibb & Sons Inc | Uso de inhibidores de la proteina-farnesil transferasa para la preparacion de un medicamento para bloquear la transformacion neoplastica de celulas inducidas por oncogenes ras. |
| JPH05239058A (ja) | 1991-12-17 | 1993-09-17 | Fujisawa Pharmaceut Co Ltd | ３−ピロリジニルチオ−１−アザビシクロ［３．２．０ヘプト−２−エン−２−カルボン酸化合物 |
| GB9202298D0 (en) | 1992-02-04 | 1992-03-18 | Ici Plc | Antibiotic compounds |
| CZ290002B6 (cs) | 1992-03-11 | 2002-05-15 | Sankyo Company Limited | Antimikrobiální karbapenemové deriváty, způsob výroby a farmaceutický prostředek |
| GB9304156D0 (en) | 1992-03-26 | 1993-04-21 | Zeneca Ltd | Antibiotic compounds |
| CA2091309A1 (fr) | 1992-03-26 | 1993-09-27 | Frederic H. Jung | Composes antibiotiques |
| US5608056A (en) | 1992-04-13 | 1997-03-04 | Fujisawa Pharmaceutical Co., Ltd. | Substituted 3-pyrrolidinylthio-carbapenems as antimicrobial agents |
| EP0581502B1 (fr) | 1992-07-21 | 1998-10-21 | Zeneca Limited | Dérivés de carbapénème antibiotiques |
| EP0581501B1 (fr) | 1992-07-21 | 1998-09-09 | Zeneca Limited | Dérivés de carbapénème antibiotiques |
| CA2099818A1 (fr) | 1992-07-21 | 1994-01-22 | Frederic H. Jung | Composes antibiotiques |
| EP0590885B1 (fr) | 1992-09-28 | 2000-03-15 | Zeneca Limited | Dérivés de carbapénème antibiotiques |
| CA2106330A1 (fr) | 1992-10-07 | 1994-04-08 | Patrice J. Siret | Composes antibiotiques |
| CA2118985A1 (fr) | 1993-04-02 | 1994-10-03 | Dinesh V. Patel | Inhibiteurs heterocycliques de la farnesyl proteine transferase |
| EP0703905A1 (fr) | 1993-06-18 | 1996-04-03 | Merck & Co. Inc. | Inhibiteurs de farnesyle-proteine transferase |
| JP2534823B2 (ja) | 1993-07-07 | 1996-09-18 | 日本電気株式会社 | 印刷装置 |
| US5468733A (en) | 1993-09-30 | 1995-11-21 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| JPH09504277A (ja) | 1993-09-30 | 1997-04-28 | メルク エンド カンパニー インコーポレーテッド | ファルネシル−タンパク質トランスフェラーゼの阻害剤 |
| CA2155448A1 (fr) | 1994-08-11 | 1996-02-12 | Katerina Leftheris | Inhibiteurs de la farnesyl-proteine-transferase |
| US5571835A (en) | 1994-09-29 | 1996-11-05 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| JPH11503419A (ja) | 1995-03-29 | 1999-03-26 | メルク エンド カンパニー インコーポレーテッド | ファルネシル−タンパク質トランスフェラーゼ阻害剤 |
| TR199800157T1 (xx) | 1995-07-31 | 1998-06-22 | Shionogi & Co.,Ltd. | Fosfolipaz A2 inhibit�r� aktivitesi olan pirolidin t�revleri. |
| GB9515975D0 (en) | 1995-08-04 | 1995-10-04 | Zeneca Ltd | Chemical compounds |
| JPH1050029A (ja) | 1996-05-28 | 1998-02-20 | Nobuyuki Higuchi | 情報記憶装置 |
| EP0923545A1 (fr) * | 1996-08-17 | 1999-06-23 | Zeneca Limited | 3-mercaptopyrrolidines comme inhibiteurs de la farnesyle-proteine transferase |
| AU5772698A (en) | 1997-01-29 | 1998-08-18 | Zeneca Limited | Inhibitors of farnesyl protein transferase |
| AU7473398A (en) | 1997-05-07 | 1998-11-27 | University Of Pittsburgh | Inhibitors of protein isoprenyl transferases |
| AU2435199A (en) * | 1998-02-10 | 1999-08-30 | Astrazeneca Uk Limited | Farnesyl transferase inhibitors |
-
1999
- 1999-12-22 GB GBGB9930318.2A patent/GB9930318D0/en not_active Ceased
-
2000
- 2000-12-18 PL PL00355887A patent/PL355887A1/xx not_active Application Discontinuation
- 2000-12-18 CA CA002387579A patent/CA2387579A1/fr not_active Abandoned
- 2000-12-18 EP EP00985605A patent/EP1255733B1/fr not_active Expired - Lifetime
- 2000-12-18 CN CNA2005100563322A patent/CN1680313A/zh active Pending
- 2000-12-18 BR BR0016669-3A patent/BR0016669A/pt not_active IP Right Cessation
- 2000-12-18 CZ CZ20022125A patent/CZ20022125A3/cs unknown
- 2000-12-18 WO PCT/GB2000/004856 patent/WO2001046137A1/fr active IP Right Grant
- 2000-12-18 AU AU22013/01A patent/AU776003B2/en not_active Ceased
- 2000-12-18 CN CNB008174202A patent/CN1229344C/zh not_active Expired - Fee Related
- 2000-12-18 KR KR1020027008034A patent/KR20020063251A/ko not_active Application Discontinuation
- 2000-12-18 SK SK864-2002A patent/SK8642002A3/sk unknown
- 2000-12-18 AT AT00985605T patent/ATE316074T1/de not_active IP Right Cessation
- 2000-12-18 DE DE60025650T patent/DE60025650D1/de not_active Expired - Lifetime
- 2000-12-18 US US10/110,690 patent/US7101897B2/en not_active Expired - Fee Related
- 2000-12-18 RU RU2002119405/04A patent/RU2259997C2/ru not_active IP Right Cessation
- 2000-12-18 HU HU0204135A patent/HUP0204135A3/hu unknown
- 2000-12-18 IL IL14987100A patent/IL149871A0/xx unknown
- 2000-12-18 JP JP2001547048A patent/JP3742593B2/ja not_active Expired - Fee Related
- 2000-12-18 MX MXPA02005981A patent/MXPA02005981A/es unknown
- 2000-12-18 EE EEP200200206A patent/EE200200206A/xx unknown
- 2000-12-18 NZ NZ518341A patent/NZ518341A/xx unknown
- 2000-12-20 MY MYPI20006011A patent/MY133606A/en unknown
- 2000-12-21 AR ARP000106845A patent/AR029460A1/es not_active Application Discontinuation
- 2000-12-22 CO CO00097282A patent/CO5360641A1/es not_active Application Discontinuation
-
2002
- 2002-04-05 ZA ZA200202694A patent/ZA200202694B/en unknown
- 2002-04-23 IS IS6358A patent/IS6358A/is unknown
- 2002-06-18 NO NO20022924A patent/NO20022924L/no unknown
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