EE200200206A - Farnesüüli transferaasiinhibiitorid - Google Patents

Farnesüüli transferaasiinhibiitorid

Info

Publication number
EE200200206A
EE200200206A EEP200200206A EEP200200206A EE200200206A EE 200200206 A EE200200206 A EE 200200206A EE P200200206 A EEP200200206 A EE P200200206A EE P200200206 A EEP200200206 A EE P200200206A EE 200200206 A EE200200206 A EE 200200206A
Authority
EE
Estonia
Prior art keywords
transferase inhibitors
farnesyl transferase
farnesyl
inhibitors
transferase
Prior art date
Application number
EEP200200206A
Other languages
English (en)
Estonian (et)
Inventor
Thomas Boyle Francis
Michael Wardleworth James
Matusiak Zbigniew
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of EE200200206A publication Critical patent/EE200200206A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
EEP200200206A 1999-12-22 2000-12-18 Farnesüüli transferaasiinhibiitorid EE200200206A (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9930318.2A GB9930318D0 (en) 1999-12-22 1999-12-22 Novel compounds
PCT/GB2000/004856 WO2001046137A1 (fr) 1999-12-22 2000-12-18 Inhibiteurs de farnesyltransferase

Publications (1)

Publication Number Publication Date
EE200200206A true EE200200206A (et) 2003-04-15

Family

ID=10866834

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200200206A EE200200206A (et) 1999-12-22 2000-12-18 Farnesüüli transferaasiinhibiitorid

Country Status (27)

Country Link
US (1) US7101897B2 (fr)
EP (1) EP1255733B1 (fr)
JP (1) JP3742593B2 (fr)
KR (1) KR20020063251A (fr)
CN (2) CN1680313A (fr)
AR (1) AR029460A1 (fr)
AT (1) ATE316074T1 (fr)
AU (1) AU776003B2 (fr)
BR (1) BR0016669A (fr)
CA (1) CA2387579A1 (fr)
CO (1) CO5360641A1 (fr)
CZ (1) CZ20022125A3 (fr)
DE (1) DE60025650D1 (fr)
EE (1) EE200200206A (fr)
GB (1) GB9930318D0 (fr)
HU (1) HUP0204135A3 (fr)
IL (1) IL149871A0 (fr)
IS (1) IS6358A (fr)
MX (1) MXPA02005981A (fr)
MY (1) MY133606A (fr)
NO (1) NO20022924L (fr)
NZ (1) NZ518341A (fr)
PL (1) PL355887A1 (fr)
RU (1) RU2259997C2 (fr)
SK (1) SK8642002A3 (fr)
WO (1) WO2001046137A1 (fr)
ZA (1) ZA200202694B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005117864A1 (fr) * 2004-05-28 2005-12-15 Astrazeneca Ab Produit combine comprenant de l'anastrozole et un inhibiteur double de la prenyl transferase
JP4880473B2 (ja) * 2004-10-08 2012-02-22 壽製薬株式会社 ホスホン酸誘導体及び血中の高リン酸が関与する疾患の治療剤
US20110136867A1 (en) * 2006-02-02 2011-06-09 Justman Craig J Treatment of Synucleinopathies
WO2009151683A2 (fr) 2008-03-12 2009-12-17 Link Medicine Corporation Inhibiteurs de quinolinone farnésyl transférase pour le traitement de synucléinopathies et d'autres indications
BRPI0920927A2 (pt) 2008-11-13 2019-09-24 Link Medicine Corp derivados de azaquinolinona e usos dos mesmos
CN102448458B (zh) 2009-03-18 2015-07-22 小利兰·斯坦福大学理事会 治疗黄病毒科病毒感染的方法和组合物
WO2011088126A2 (fr) * 2010-01-13 2011-07-21 Eiger Biopharmaceuticals, Inc. Traitement d'une infection virale avec des inhibiteurs de prényltransférase

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1283906C (fr) 1983-05-09 1991-05-07 Makoto Sunagawa COMPOSE DE .beta.-LACTAM ET PROCEDE DE PRODUCTION
JPS60233076A (ja) 1984-05-03 1985-11-19 Sumitomo Chem Co Ltd 新規なβ−ラクタム化合物およびその製造法
DE3579888D1 (de) 1984-11-08 1990-10-31 Sumitomo Pharma Carbapenemverbindungen und deren herstellung.
KR880006244A (ko) 1986-11-24 1988-07-22 후지사와 도모 기찌 로 3-피롤리디닐티오-1-아자바이스클로[3.2.0]햅트2-엔-2-카르복실산 화합물 및 이의 제조방법
GB8921635D0 (en) 1989-09-25 1989-11-08 Fujisawa Pharmaceutical Co 3-pyrrolidinylthio-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid derivatives
CA2036163C (fr) 1990-02-14 2001-06-19 Makoto Sunagawa Nouveaux composes de beta-lactame et leur production
IE910606A1 (en) 1990-02-23 1991-08-28 Sankyo Co Carbapenem derivatives having antibiotic activity, their¹preparation and their use
GB9107363D0 (en) 1991-04-08 1991-05-22 Ici Plc Antibiotic compounds
US6083917A (en) 1990-04-18 2000-07-04 Board Of Regents, The University Of Texas System Methods and compositions for the identification, characterization and inhibition of farnesyltransferase
US5185248A (en) 1990-05-08 1993-02-09 E. R. Squibb & Sons, Inc. Farnesyl-protein transferase assay for identifying compounds that block neoplastic transformation
JPH0578360A (ja) 1991-01-31 1993-03-30 Banyu Pharmaceut Co Ltd ２−［２−（スルフアモイルアルキル）ピロリジニルチオカルバペネム誘導体
GB9107341D0 (en) 1991-04-08 1991-05-22 Ici Plc Antibiotic compounds
GB9107342D0 (en) 1991-04-08 1991-05-22 Ici Plc Antibiotic compounds
JP2559949B2 (ja) 1991-06-04 1996-12-04 三共株式会社 １−メチルカルバペネム誘導体
JPH04368386A (ja) 1991-06-18 1992-12-21 Sankyo Co Ltd １−メチルカルバペネム−３−カルボン酸の製造法
US5360798A (en) 1991-07-04 1994-11-01 Shionogi Seiyaku Kabushiki Kaisha Aminooxypyrrolidinylthiocarbapenem compounds
ES2075630T3 (es) 1991-10-11 1995-10-01 Squibb & Sons Inc Uso de inhibidores de la proteina-farnesil transferasa para la preparacion de un medicamento para bloquear la transformacion neoplastica de celulas inducidas por oncogenes ras.
JPH05239058A (ja) 1991-12-17 1993-09-17 Fujisawa Pharmaceut Co Ltd ３−ピロリジニルチオ−１−アザビシクロ［３．２．０ヘプト−２−エン−２−カルボン酸化合物
GB9202298D0 (en) 1992-02-04 1992-03-18 Ici Plc Antibiotic compounds
CZ290002B6 (cs) 1992-03-11 2002-05-15 Sankyo Company Limited Antimikrobiální karbapenemové deriváty, způsob výroby a farmaceutický prostředek
GB9304156D0 (en) 1992-03-26 1993-04-21 Zeneca Ltd Antibiotic compounds
CA2091309A1 (fr) 1992-03-26 1993-09-27 Frederic H. Jung Composes antibiotiques
US5608056A (en) 1992-04-13 1997-03-04 Fujisawa Pharmaceutical Co., Ltd. Substituted 3-pyrrolidinylthio-carbapenems as antimicrobial agents
EP0581502B1 (fr) 1992-07-21 1998-10-21 Zeneca Limited Dérivés de carbapénème antibiotiques
EP0581501B1 (fr) 1992-07-21 1998-09-09 Zeneca Limited Dérivés de carbapénème antibiotiques
CA2099818A1 (fr) 1992-07-21 1994-01-22 Frederic H. Jung Composes antibiotiques
EP0590885B1 (fr) 1992-09-28 2000-03-15 Zeneca Limited Dérivés de carbapénème antibiotiques
CA2106330A1 (fr) 1992-10-07 1994-04-08 Patrice J. Siret Composes antibiotiques
CA2118985A1 (fr) 1993-04-02 1994-10-03 Dinesh V. Patel Inhibiteurs heterocycliques de la farnesyl proteine transferase
EP0703905A1 (fr) 1993-06-18 1996-04-03 Merck & Co. Inc. Inhibiteurs de farnesyle-proteine transferase
JP2534823B2 (ja) 1993-07-07 1996-09-18 日本電気株式会社 印刷装置
US5468733A (en) 1993-09-30 1995-11-21 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
JPH09504277A (ja) 1993-09-30 1997-04-28 メルク エンド カンパニー インコーポレーテッド ファルネシル−タンパク質トランスフェラーゼの阻害剤
CA2155448A1 (fr) 1994-08-11 1996-02-12 Katerina Leftheris Inhibiteurs de la farnesyl-proteine-transferase
US5571835A (en) 1994-09-29 1996-11-05 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
JPH11503419A (ja) 1995-03-29 1999-03-26 メルク エンド カンパニー インコーポレーテッド ファルネシル−タンパク質トランスフェラーゼ阻害剤
TR199800157T1 (xx) 1995-07-31 1998-06-22 Shionogi & Co.,Ltd. Fosfolipaz A2 inhibit�r� aktivitesi olan pirolidin t�revleri.
GB9515975D0 (en) 1995-08-04 1995-10-04 Zeneca Ltd Chemical compounds
JPH1050029A (ja) 1996-05-28 1998-02-20 Nobuyuki Higuchi 情報記憶装置
EP0923545A1 (fr) * 1996-08-17 1999-06-23 Zeneca Limited 3-mercaptopyrrolidines comme inhibiteurs de la farnesyle-proteine transferase
AU5772698A (en) 1997-01-29 1998-08-18 Zeneca Limited Inhibitors of farnesyl protein transferase
AU7473398A (en) 1997-05-07 1998-11-27 University Of Pittsburgh Inhibitors of protein isoprenyl transferases
AU2435199A (en) * 1998-02-10 1999-08-30 Astrazeneca Uk Limited Farnesyl transferase inhibitors

Also Published As

Publication number Publication date
CN1411442A (zh) 2003-04-16
JP2003518091A (ja) 2003-06-03
AU2201301A (en) 2001-07-03
DE60025650D1 (de) 2006-04-06
EP1255733A1 (fr) 2002-11-13
CZ20022125A3 (cs) 2002-09-11
BR0016669A (pt) 2002-10-08
AU776003B2 (en) 2004-08-19
WO2001046137A1 (fr) 2001-06-28
NO20022924D0 (no) 2002-06-18
ZA200202694B (en) 2003-12-31
RU2259997C2 (ru) 2005-09-10
HUP0204135A3 (en) 2005-03-29
CN1229344C (zh) 2005-11-30
MXPA02005981A (es) 2005-07-01
JP3742593B2 (ja) 2006-02-08
GB9930318D0 (en) 2000-02-09
PL355887A1 (en) 2004-05-31
RU2002119405A (ru) 2004-01-10
SK8642002A3 (en) 2002-12-03
CN1680313A (zh) 2005-10-12
IS6358A (is) 2002-04-23
IL149871A0 (en) 2002-11-10
CA2387579A1 (fr) 2001-06-28
ATE316074T1 (de) 2006-02-15
NO20022924L (no) 2002-06-18
CO5360641A1 (es) 2004-01-30
NZ518341A (en) 2004-01-30
HUP0204135A2 (hu) 2003-03-28
AR029460A1 (es) 2003-07-02
KR20020063251A (ko) 2002-08-01
US20030083348A1 (en) 2003-05-01
MY133606A (en) 2007-11-30
EP1255733B1 (fr) 2006-01-18
US7101897B2 (en) 2006-09-05

Similar Documents

Publication Publication Date Title
PT1226136E (pt) Inibidores da tirosina quinase
PT1181017E (pt) Inibidores de metaloproteases
NO996571L (no) Inhibitorer for farnesyl-protein-transferase
NO963860D0 (no) Isoprenyl-transferase-inhibitorer
NO20021239D0 (no) Pteridinoner som kinase-inhibitorer
PT1224195E (pt) C-aril-glicosidos inibidores de tgls2
EE04309B1 (et) Farnesüül-proteiini transferaasi inhibiitorid
PT1194404E (pt) Inibidores de aspartil-protease
NO20012960D0 (no) Farnesylproteintransferase-inhibitorer
DK1272488T3 (da) Tri-aryl-substitueret ethan-PDE4-inhibitorer
DK1339695T3 (da) Farnesyltransferase-inhibitorer
ATE252547T1 (de) Matrixmetalloproteinaseinhibitoren
EE200200206A (et) Farnesüüli transferaasiinhibiitorid
NO20012961D0 (no) Trisykliske farnesylproteintransferase-inhibitorer
DE60009260D1 (de) Thiopyranderivate as mmp-inhibitoren
ATE214367T1 (de) Farnesyl transferase inhibitoren
AU3514302A (en) 0ovel farnesyl protein transferase inhibitors
ATE323096T1 (de) Prenyltransferase-inhibitoren
NO20015827D0 (no) Neuronal död inhibitorer
NO20022923D0 (no) Inhibitorer av farnesyl-protein-transferase
IDP000027420A (id) Inhibitor-inhibitor kinase pirolotriazin