SK67596A3 - Hirudin conjugates from hirudine and lipophilic compounds - Google Patents
Hirudin conjugates from hirudine and lipophilic compounds Download PDFInfo
- Publication number
- SK67596A3 SK67596A3 SK675-96A SK67596A SK67596A3 SK 67596 A3 SK67596 A3 SK 67596A3 SK 67596 A SK67596 A SK 67596A SK 67596 A3 SK67596 A3 SK 67596A3
- Authority
- SK
- Slovakia
- Prior art keywords
- hirudin
- acid
- lipophilic
- compounds
- lipophilic compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/545—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Fats And Perfumes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Extrusion Moulding Of Plastics Or The Like (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Ink Jet (AREA)
- Silicon Polymers (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4341115 | 1993-12-02 | ||
| PCT/EP1994/003901 WO1995015183A1 (de) | 1993-12-02 | 1994-11-25 | Hirudin-konjugate aus hirudin und lipophilen verbindungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK67596A3 true SK67596A3 (en) | 1996-12-04 |
Family
ID=6504029
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK675-96A SK67596A3 (en) | 1993-12-02 | 1994-11-25 | Hirudin conjugates from hirudine and lipophilic compounds |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5919762A (hu) |
| EP (1) | EP0730473B1 (hu) |
| JP (1) | JPH09505810A (hu) |
| CN (1) | CN1142776A (hu) |
| AT (1) | ATE204763T1 (hu) |
| AU (1) | AU679811B2 (hu) |
| BR (1) | BR9408195A (hu) |
| CA (1) | CA2176967A1 (hu) |
| CZ (1) | CZ157096A3 (hu) |
| DE (2) | DE4437502A1 (hu) |
| DK (1) | DK0730473T3 (hu) |
| ES (1) | ES2163487T3 (hu) |
| FI (1) | FI962299A0 (hu) |
| GR (1) | GR3036938T3 (hu) |
| HR (1) | HRP940968A2 (hu) |
| HU (1) | HUT74390A (hu) |
| IL (1) | IL111811A0 (hu) |
| NO (1) | NO962261L (hu) |
| NZ (1) | NZ276410A (hu) |
| PL (1) | PL314797A1 (hu) |
| PT (1) | PT730473E (hu) |
| SG (1) | SG49156A1 (hu) |
| SK (1) | SK67596A3 (hu) |
| WO (1) | WO1995015183A1 (hu) |
| ZA (1) | ZA949562B (hu) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4437604A1 (de) * | 1994-10-21 | 1996-04-25 | Basf Ag | Konjugate aus einem Poly- oder Oligopeptid und einer niedermolekularen lipophilen Verbindung |
| US5726168A (en) * | 1995-10-12 | 1998-03-10 | Eli Lilly And Company | Lipophilic benzothiophenes |
| DE19915862A1 (de) * | 1999-04-08 | 2000-10-12 | Max Planck Gesellschaft | Verwendung von molekulargewichtserweitertem Hirudin als Antikoagulans bei der extrakorporalen Nierenersatztherapie |
| EP1448263B1 (en) * | 2001-10-24 | 2009-01-07 | Power Paper Ltd. | Device for controlled delivery of active substance into the skin |
| US7438925B2 (en) * | 2002-08-26 | 2008-10-21 | Biovention Holdings Ltd. | Drug eluting coatings for medical implants |
| BR102017005783A2 (pt) * | 2017-03-21 | 2018-10-02 | Fund Butantan | processo de obtenção de esculptina e seus fragmentos, esculptina recombinante e seus usos |
| KR102366360B1 (ko) * | 2021-06-29 | 2022-02-23 | (주)네오팜 | 신규한 유사 세라마이드 화합물 및 이를 포함하는 피부 외용제 조성물 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0077529B1 (de) * | 1981-10-16 | 1985-07-17 | Sanol Schwarz GmbH | Arzneimittelformulierung |
| DE3445532A1 (de) * | 1984-12-13 | 1986-06-19 | Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn | Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten |
| US4939174A (en) * | 1988-02-26 | 1990-07-03 | Shashoua Victor E | Appetite suppression with dopamine-fatty acid conjugates |
| DE3819079A1 (de) * | 1988-06-04 | 1989-12-07 | Hoechst Ag | Hirudin-derivate mit verzoegerter wirkung |
| WO1990010448A2 (en) * | 1989-03-07 | 1990-09-20 | Genentech, Inc. | Covalent conjugates of lipid and oligonucleotide |
| DE4014260A1 (de) * | 1989-12-01 | 1991-06-06 | Basf Ag | Hirudinpolyalkylenglykolkonjugate |
| EP0502962B1 (de) * | 1989-12-01 | 1996-03-13 | BASF Aktiengesellschaft | Hirudin-Muteine und deren Polyalkylenglykolkonjugate |
| DE69024230T2 (de) * | 1989-12-22 | 1996-05-02 | Commw Scient Ind Res Org | An fette gebundene aminosäuren, peptide oder deren derivate |
| EP0537299A1 (en) * | 1990-03-29 | 1993-04-21 | Gilead Sciences, Inc. | Oligonucleotide-transport agent disulfide conjugates |
| US5256641A (en) * | 1990-11-01 | 1993-10-26 | State Of Oregon | Covalent polar lipid-peptide conjugates for immunological targeting |
| WO1992019233A2 (en) * | 1991-04-29 | 1992-11-12 | Control Delivery Systems, Inc. | Sustained release composition and methods of use thereof |
| DE69218888D1 (de) * | 1991-05-02 | 1997-05-15 | Pierre Baudet | N-phenyl-cinnamamide, die einen schutz verleihen gegen schädigende effekte ultravioletten lichtes |
| US5359030A (en) * | 1993-05-10 | 1994-10-25 | Protein Delivery, Inc. | Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same |
-
1994
- 1994-10-20 DE DE4437502A patent/DE4437502A1/de not_active Withdrawn
- 1994-11-25 SG SG1996006978A patent/SG49156A1/en unknown
- 1994-11-25 SK SK675-96A patent/SK67596A3/sk unknown
- 1994-11-25 US US08/652,511 patent/US5919762A/en not_active Expired - Lifetime
- 1994-11-25 PT PT95901432T patent/PT730473E/pt unknown
- 1994-11-25 CZ CZ961570A patent/CZ157096A3/cs unknown
- 1994-11-25 ES ES95901432T patent/ES2163487T3/es not_active Expired - Lifetime
- 1994-11-25 BR BR9408195A patent/BR9408195A/pt not_active Application Discontinuation
- 1994-11-25 CA CA002176967A patent/CA2176967A1/en not_active Abandoned
- 1994-11-25 DK DK95901432T patent/DK0730473T3/da active
- 1994-11-25 NZ NZ276410A patent/NZ276410A/en unknown
- 1994-11-25 AU AU10670/95A patent/AU679811B2/en not_active Ceased
- 1994-11-25 WO PCT/EP1994/003901 patent/WO1995015183A1/de active IP Right Grant
- 1994-11-25 AT AT95901432T patent/ATE204763T1/de active
- 1994-11-25 JP JP7515283A patent/JPH09505810A/ja not_active Ceased
- 1994-11-25 HU HU9601471A patent/HUT74390A/hu unknown
- 1994-11-25 PL PL94314797A patent/PL314797A1/xx unknown
- 1994-11-25 EP EP95901432A patent/EP0730473B1/de not_active Expired - Lifetime
- 1994-11-25 DE DE59409847T patent/DE59409847D1/de not_active Expired - Lifetime
- 1994-11-25 CN CN94194897A patent/CN1142776A/zh active Pending
- 1994-11-29 IL IL11181194A patent/IL111811A0/xx unknown
- 1994-12-01 HR HRP4341115.0A patent/HRP940968A2/hr not_active Application Discontinuation
- 1994-12-01 ZA ZA949562A patent/ZA949562B/xx unknown
-
1996
- 1996-05-31 NO NO962261A patent/NO962261L/no unknown
- 1996-05-31 FI FI962299A patent/FI962299A0/fi not_active Application Discontinuation
-
2001
- 2001-10-18 GR GR20010401806T patent/GR3036938T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUT74390A (en) | 1996-12-30 |
| US5919762A (en) | 1999-07-06 |
| GR3036938T3 (en) | 2002-01-31 |
| AU679811B2 (en) | 1997-07-10 |
| WO1995015183A1 (de) | 1995-06-08 |
| SG49156A1 (en) | 1998-05-18 |
| NO962261D0 (no) | 1996-05-31 |
| CN1142776A (zh) | 1997-02-12 |
| JPH09505810A (ja) | 1997-06-10 |
| AU1067095A (en) | 1995-06-19 |
| FI962299A (fi) | 1996-05-31 |
| EP0730473B1 (de) | 2001-08-29 |
| DK0730473T3 (da) | 2001-10-08 |
| CA2176967A1 (en) | 1995-06-08 |
| NZ276410A (en) | 1997-03-24 |
| FI962299A0 (fi) | 1996-05-31 |
| DE59409847D1 (de) | 2001-10-04 |
| HU9601471D0 (en) | 1996-07-29 |
| EP0730473A1 (de) | 1996-09-11 |
| ES2163487T3 (es) | 2002-02-01 |
| HRP940968A2 (en) | 1997-08-31 |
| PL314797A1 (en) | 1996-09-30 |
| PT730473E (pt) | 2002-02-28 |
| BR9408195A (pt) | 1997-08-26 |
| NO962261L (no) | 1996-05-31 |
| CZ157096A3 (en) | 1996-09-11 |
| ZA949562B (en) | 1996-06-03 |
| ATE204763T1 (de) | 2001-09-15 |
| IL111811A0 (en) | 1995-01-24 |
| DE4437502A1 (de) | 1995-06-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP3466614B2 (ja) | 血栓症のインヒビター | |
| US5990083A (en) | Multicatalytic protease inhibitors | |
| KR100438244B1 (ko) | 사이클릭결합저해제 | |
| EP3405477B1 (en) | Inhibitors of transglutaminases | |
| EP0298820A1 (fr) | Nouveaux dérivés peptidiques et leur application notamment en thérapeutique | |
| US5109118A (en) | Modified biologically active proteins | |
| US5550262A (en) | Multicatalytic protease inhibitors | |
| SK67596A3 (en) | Hirudin conjugates from hirudine and lipophilic compounds | |
| US6403554B2 (en) | Polyunsaturated fatty acid derivatives and their use | |
| JPH06500073A (ja) | ヒルジンのアミノ酸配列に基づくトロンビン阻害剤 | |
| JP2008531482A (ja) | Ｃ末端がｐｅｇ化された成長ホルモン | |
| EP0496013A1 (en) | Synthetic peptide derived from human lipocortin V and use thereof | |
| CA2335079C (en) | Composition for the treatement of immune deficiencies and methods for its preparation and use | |
| EP1414794A1 (en) | Allylmercaptocaptopril compounds and uses thereof | |
| AU765465B2 (en) | Polyunsaturated fatty acid derivatives and their use | |
| AU2002305744A1 (en) | Allylmercaptocaptopril compounds and uses thereof | |
| CN118742329A (zh) | 包含抗组织因子抗体-药物缀合物的药物组合物 | |
| WO2005085283A1 (ja) | 修飾インターロイキン−１１及びそれを含有する医薬組成物 | |
| JPH06228192A (ja) | 持続性エンドセリン拮抗剤 | |
| FR2617169A1 (fr) | Nouveaux derives peptidiques et leur application notamment en therapeutique | |
| CA2034618A1 (en) | Synthetic peptide derived from human lipocortin v and use thereof | |
| JPH03227941A (ja) | 急性循環不全およびそれに伴う臓器機能不全に対する治療用医薬組成物 |