NO962261L - Hirudin-konjugater av hirudin og lipofile forbindelser - Google Patents

Hirudin-konjugater av hirudin og lipofile forbindelser

Info

Publication number
NO962261L
NO962261L NO962261A NO962261A NO962261L NO 962261 L NO962261 L NO 962261L NO 962261 A NO962261 A NO 962261A NO 962261 A NO962261 A NO 962261A NO 962261 L NO962261 L NO 962261L
Authority
NO
Norway
Prior art keywords
hirudin
pct
lipophilic compounds
conjugates
date
Prior art date
Application number
NO962261A
Other languages
English (en)
Other versions
NO962261D0 (no
Inventor
Jurgen Schweden
Peter Eckes
Wilfried Hornberger
Thomas Subkowski
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of NO962261L publication Critical patent/NO962261L/no
Publication of NO962261D0 publication Critical patent/NO962261D0/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Fats And Perfumes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Extrusion Moulding Of Plastics Or The Like (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Ink Jet (AREA)
  • Silicon Polymers (AREA)

Abstract

Det beskrives nye hirudin-konjugater dannet av et hirudin og én eller flere lipofile forbindelser, hvor den lipofile forbindelse oppviser en oktanol/vann-fordelingskoeffisient på mer enn 1,8 og kjemisk er forbundet med hirudinet, deres fremstilling og deres anvendelse.
NO962261A 1993-12-02 1996-05-31 Hirudin-konjugater av hirudin og lipofile forbindelser NO962261D0 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4341115 1993-12-02
PCT/EP1994/003901 WO1995015183A1 (de) 1993-12-02 1994-11-25 Hirudin-konjugate aus hirudin und lipophilen verbindungen

Publications (2)

Publication Number Publication Date
NO962261L true NO962261L (no) 1996-05-31
NO962261D0 NO962261D0 (no) 1996-05-31

Family

ID=6504029

Family Applications (1)

Application Number Title Priority Date Filing Date
NO962261A NO962261D0 (no) 1993-12-02 1996-05-31 Hirudin-konjugater av hirudin og lipofile forbindelser

Country Status (25)

Country Link
US (1) US5919762A (no)
EP (1) EP0730473B1 (no)
JP (1) JPH09505810A (no)
CN (1) CN1142776A (no)
AT (1) ATE204763T1 (no)
AU (1) AU679811B2 (no)
BR (1) BR9408195A (no)
CA (1) CA2176967A1 (no)
CZ (1) CZ157096A3 (no)
DE (2) DE4437502A1 (no)
DK (1) DK0730473T3 (no)
ES (1) ES2163487T3 (no)
FI (1) FI962299A (no)
GR (1) GR3036938T3 (no)
HR (1) HRP940968A2 (no)
HU (1) HUT74390A (no)
IL (1) IL111811A0 (no)
NO (1) NO962261D0 (no)
NZ (1) NZ276410A (no)
PL (1) PL314797A1 (no)
PT (1) PT730473E (no)
SG (1) SG49156A1 (no)
SK (1) SK67596A3 (no)
WO (1) WO1995015183A1 (no)
ZA (1) ZA949562B (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4437604A1 (de) * 1994-10-21 1996-04-25 Basf Ag Konjugate aus einem Poly- oder Oligopeptid und einer niedermolekularen lipophilen Verbindung
US5726168A (en) * 1995-10-12 1998-03-10 Eli Lilly And Company Lipophilic benzothiophenes
DE19915862A1 (de) * 1999-04-08 2000-10-12 Max Planck Gesellschaft Verwendung von molekulargewichtserweitertem Hirudin als Antikoagulans bei der extrakorporalen Nierenersatztherapie
CN1606461B (zh) * 2001-10-24 2011-03-23 纸型电池有限公司 一种用制剂作皮肤治疗的装置、一种成套器具及皮肤贴片
US7438925B2 (en) * 2002-08-26 2008-10-21 Biovention Holdings Ltd. Drug eluting coatings for medical implants
BR102017005783A2 (pt) * 2017-03-21 2018-10-02 Fund Butantan processo de obtenção de esculptina e seus fragmentos, esculptina recombinante e seus usos
KR102366360B1 (ko) * 2021-06-29 2022-02-23 (주)네오팜 신규한 유사 세라마이드 화합물 및 이를 포함하는 피부 외용제 조성물

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3264782D1 (en) * 1981-10-16 1985-08-22 Sanol Arznei Schwarz Gmbh Medicinal formulation
DE3445532A1 (de) * 1984-12-13 1986-06-19 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
US4939174A (en) * 1988-02-26 1990-07-03 Shashoua Victor E Appetite suppression with dopamine-fatty acid conjugates
DE3819079A1 (de) * 1988-06-04 1989-12-07 Hoechst Ag Hirudin-derivate mit verzoegerter wirkung
ATE104857T1 (de) * 1989-03-07 1994-05-15 Genentech Inc Kovalente konjugate von lipiden und oligonukleotiden.
DE4014260A1 (de) * 1989-12-01 1991-06-06 Basf Ag Hirudinpolyalkylenglykolkonjugate
US5663141A (en) * 1989-12-01 1997-09-02 Basf Aktiengesellschaft Hirudin/polyalkylene glycol conjugates and hirudin muteins
DE69024230T2 (de) * 1989-12-22 1996-05-02 Commw Scient Ind Res Org An fette gebundene aminosäuren, peptide oder deren derivate
CA2079109A1 (en) * 1990-03-29 1991-09-30 John A. Latham Oligonucleotide-transport agent disulfide conjugates
US5256641A (en) * 1990-11-01 1993-10-26 State Of Oregon Covalent polar lipid-peptide conjugates for immunological targeting
WO1992019233A2 (en) * 1991-04-29 1992-11-12 Control Delivery Systems, Inc. Sustained release composition and methods of use thereof
WO1992019223A1 (fr) * 1991-05-02 1992-11-12 Pierre Baudet Les n-phenyl-cinnamamides, protecteurs contre les effets nocifs de la lumiere ultra-violette
US5359030A (en) * 1993-05-10 1994-10-25 Protein Delivery, Inc. Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same

Also Published As

Publication number Publication date
ZA949562B (en) 1996-06-03
IL111811A0 (en) 1995-01-24
DE4437502A1 (de) 1995-06-08
EP0730473B1 (de) 2001-08-29
US5919762A (en) 1999-07-06
SK67596A3 (en) 1996-12-04
EP0730473A1 (de) 1996-09-11
AU1067095A (en) 1995-06-19
CA2176967A1 (en) 1995-06-08
FI962299A0 (fi) 1996-05-31
HRP940968A2 (en) 1997-08-31
FI962299A (fi) 1996-05-31
PT730473E (pt) 2002-02-28
CN1142776A (zh) 1997-02-12
DK0730473T3 (da) 2001-10-08
HUT74390A (en) 1996-12-30
AU679811B2 (en) 1997-07-10
NO962261D0 (no) 1996-05-31
JPH09505810A (ja) 1997-06-10
CZ157096A3 (en) 1996-09-11
SG49156A1 (en) 1998-05-18
BR9408195A (pt) 1997-08-26
ES2163487T3 (es) 2002-02-01
PL314797A1 (en) 1996-09-30
GR3036938T3 (en) 2002-01-31
DE59409847D1 (de) 2001-10-04
HU9601471D0 (en) 1996-07-29
ATE204763T1 (de) 2001-09-15
WO1995015183A1 (de) 1995-06-08
NZ276410A (en) 1997-03-24

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