GR3036938T3 - Hirudin conjugates from hirudin and lipophilic compounds - Google Patents
Hirudin conjugates from hirudin and lipophilic compoundsInfo
- Publication number
- GR3036938T3 GR3036938T3 GR20010401806T GR20010401806T GR3036938T3 GR 3036938 T3 GR3036938 T3 GR 3036938T3 GR 20010401806 T GR20010401806 T GR 20010401806T GR 20010401806 T GR20010401806 T GR 20010401806T GR 3036938 T3 GR3036938 T3 GR 3036938T3
- Authority
- GR
- Greece
- Prior art keywords
- hirudin
- pct
- lipophilic compounds
- conjugates
- date
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/545—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4341115 | 1993-12-02 | ||
| PCT/EP1994/003901 WO1995015183A1 (de) | 1993-12-02 | 1994-11-25 | Hirudin-konjugate aus hirudin und lipophilen verbindungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR3036938T3 true GR3036938T3 (en) | 2002-01-31 |
Family
ID=6504029
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR20010401806T GR3036938T3 (en) | 1993-12-02 | 2001-10-18 | Hirudin conjugates from hirudin and lipophilic compounds |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5919762A (el) |
| EP (1) | EP0730473B1 (el) |
| JP (1) | JPH09505810A (el) |
| CN (1) | CN1142776A (el) |
| AT (1) | ATE204763T1 (el) |
| AU (1) | AU679811B2 (el) |
| BR (1) | BR9408195A (el) |
| CA (1) | CA2176967A1 (el) |
| CZ (1) | CZ157096A3 (el) |
| DE (2) | DE4437502A1 (el) |
| DK (1) | DK0730473T3 (el) |
| ES (1) | ES2163487T3 (el) |
| FI (1) | FI962299A0 (el) |
| GR (1) | GR3036938T3 (el) |
| HR (1) | HRP940968A2 (el) |
| HU (1) | HUT74390A (el) |
| IL (1) | IL111811A0 (el) |
| NO (1) | NO962261L (el) |
| NZ (1) | NZ276410A (el) |
| PL (1) | PL314797A1 (el) |
| PT (1) | PT730473E (el) |
| SG (1) | SG49156A1 (el) |
| SK (1) | SK67596A3 (el) |
| WO (1) | WO1995015183A1 (el) |
| ZA (1) | ZA949562B (el) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4437604A1 (de) * | 1994-10-21 | 1996-04-25 | Basf Ag | Konjugate aus einem Poly- oder Oligopeptid und einer niedermolekularen lipophilen Verbindung |
| US5726168A (en) * | 1995-10-12 | 1998-03-10 | Eli Lilly And Company | Lipophilic benzothiophenes |
| DE19915862A1 (de) * | 1999-04-08 | 2000-10-12 | Max Planck Gesellschaft | Verwendung von molekulargewichtserweitertem Hirudin als Antikoagulans bei der extrakorporalen Nierenersatztherapie |
| JP4394444B2 (ja) * | 2001-10-24 | 2010-01-06 | パワー ペーパー リミティド | 活性物質の制御された皮膚内デリバリーのためのデバイス及び方法 |
| US7438925B2 (en) * | 2002-08-26 | 2008-10-21 | Biovention Holdings Ltd. | Drug eluting coatings for medical implants |
| BR102017005783A2 (pt) * | 2017-03-21 | 2018-10-02 | Fund Butantan | processo de obtenção de esculptina e seus fragmentos, esculptina recombinante e seus usos |
| KR102366360B1 (ko) * | 2021-06-29 | 2022-02-23 | (주)네오팜 | 신규한 유사 세라마이드 화합물 및 이를 포함하는 피부 외용제 조성물 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0077529B1 (de) * | 1981-10-16 | 1985-07-17 | Sanol Schwarz GmbH | Arzneimittelformulierung |
| DE3445532A1 (de) * | 1984-12-13 | 1986-06-19 | Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn | Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten |
| US4939174A (en) * | 1988-02-26 | 1990-07-03 | Shashoua Victor E | Appetite suppression with dopamine-fatty acid conjugates |
| DE3819079A1 (de) * | 1988-06-04 | 1989-12-07 | Hoechst Ag | Hirudin-derivate mit verzoegerter wirkung |
| DE69008521T2 (de) * | 1989-03-07 | 1994-10-20 | Genentech Inc | Kovalente konjugate von lipiden und oligonukleotiden. |
| JP3187044B2 (ja) * | 1989-12-01 | 2001-07-11 | ビーエーエスエフ アクチェンゲゼルシャフト | ヒルジン突然変異蛋白質及びヒルジンポリアルキレングリコール複合体 |
| DE4014260A1 (de) * | 1989-12-01 | 1991-06-06 | Basf Ag | Hirudinpolyalkylenglykolkonjugate |
| EP0506748B1 (en) * | 1989-12-22 | 1995-12-13 | Commonwealth Scientific And Industrial Research Organisation | Amino acids, peptides or derivatives thereof coupled to fats |
| AU7759291A (en) * | 1990-03-29 | 1991-10-21 | Gilead Sciences, Inc. | Oligonucleotide-transport agent disulfide conjugates |
| US5256641A (en) * | 1990-11-01 | 1993-10-26 | State Of Oregon | Covalent polar lipid-peptide conjugates for immunological targeting |
| WO1992019233A2 (en) * | 1991-04-29 | 1992-11-12 | Control Delivery Systems, Inc. | Sustained release composition and methods of use thereof |
| AU1664892A (en) * | 1991-05-02 | 1992-12-21 | Pierre Baudet | N-phenyl-cinnamamides providing protection from the harmful effects of ultraviolet light |
| US5359030A (en) * | 1993-05-10 | 1994-10-25 | Protein Delivery, Inc. | Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same |
-
1994
- 1994-10-20 DE DE4437502A patent/DE4437502A1/de not_active Withdrawn
- 1994-11-25 DE DE59409847T patent/DE59409847D1/de not_active Expired - Lifetime
- 1994-11-25 JP JP7515283A patent/JPH09505810A/ja not_active Ceased
- 1994-11-25 EP EP95901432A patent/EP0730473B1/de not_active Expired - Lifetime
- 1994-11-25 SG SG1996006978A patent/SG49156A1/en unknown
- 1994-11-25 ES ES95901432T patent/ES2163487T3/es not_active Expired - Lifetime
- 1994-11-25 NZ NZ276410A patent/NZ276410A/en unknown
- 1994-11-25 DK DK95901432T patent/DK0730473T3/da active
- 1994-11-25 WO PCT/EP1994/003901 patent/WO1995015183A1/de active IP Right Grant
- 1994-11-25 CN CN94194897A patent/CN1142776A/zh active Pending
- 1994-11-25 US US08/652,511 patent/US5919762A/en not_active Expired - Lifetime
- 1994-11-25 BR BR9408195A patent/BR9408195A/pt not_active Application Discontinuation
- 1994-11-25 PL PL94314797A patent/PL314797A1/xx unknown
- 1994-11-25 CA CA002176967A patent/CA2176967A1/en not_active Abandoned
- 1994-11-25 AT AT95901432T patent/ATE204763T1/de active
- 1994-11-25 PT PT95901432T patent/PT730473E/pt unknown
- 1994-11-25 HU HU9601471A patent/HUT74390A/hu unknown
- 1994-11-25 CZ CZ961570A patent/CZ157096A3/cs unknown
- 1994-11-25 SK SK675-96A patent/SK67596A3/sk unknown
- 1994-11-25 AU AU10670/95A patent/AU679811B2/en not_active Ceased
- 1994-11-29 IL IL11181194A patent/IL111811A0/xx unknown
- 1994-12-01 HR HRP4341115.0A patent/HRP940968A2/hr not_active Application Discontinuation
- 1994-12-01 ZA ZA949562A patent/ZA949562B/xx unknown
-
1996
- 1996-05-31 FI FI962299A patent/FI962299A0/fi not_active Application Discontinuation
- 1996-05-31 NO NO962261A patent/NO962261L/no unknown
-
2001
- 2001-10-18 GR GR20010401806T patent/GR3036938T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU1067095A (en) | 1995-06-19 |
| WO1995015183A1 (de) | 1995-06-08 |
| SK67596A3 (en) | 1996-12-04 |
| EP0730473B1 (de) | 2001-08-29 |
| FI962299A (fi) | 1996-05-31 |
| US5919762A (en) | 1999-07-06 |
| EP0730473A1 (de) | 1996-09-11 |
| ES2163487T3 (es) | 2002-02-01 |
| BR9408195A (pt) | 1997-08-26 |
| SG49156A1 (en) | 1998-05-18 |
| DK0730473T3 (da) | 2001-10-08 |
| NZ276410A (en) | 1997-03-24 |
| NO962261D0 (no) | 1996-05-31 |
| DE59409847D1 (de) | 2001-10-04 |
| FI962299A0 (fi) | 1996-05-31 |
| HRP940968A2 (en) | 1997-08-31 |
| HU9601471D0 (en) | 1996-07-29 |
| CA2176967A1 (en) | 1995-06-08 |
| CZ157096A3 (en) | 1996-09-11 |
| JPH09505810A (ja) | 1997-06-10 |
| CN1142776A (zh) | 1997-02-12 |
| HUT74390A (en) | 1996-12-30 |
| AU679811B2 (en) | 1997-07-10 |
| NO962261L (no) | 1996-05-31 |
| PL314797A1 (en) | 1996-09-30 |
| IL111811A0 (en) | 1995-01-24 |
| PT730473E (pt) | 2002-02-28 |
| ATE204763T1 (de) | 2001-09-15 |
| DE4437502A1 (de) | 1995-06-08 |
| ZA949562B (en) | 1996-06-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO308126B1 (no) | Fosfolipidbasert forbindelse, anvendelse derav samt røntgenkontrastmiddel | |
| HK1002017A1 (en) | Lyospheres comprising gonadotropin | |
| SG55184A1 (en) | New imidazopyridines | |
| BG101157A (en) | Pesticide | |
| MY117032A (en) | A novel compound form. | |
| MX9501850A (es) | Piridilpirazoles sustituidos, procedimiento para su obtencion y composiciones pesticidas y artropodicidas que los contienen. | |
| PL302918A1 (en) | Workable cement-based compositions | |
| MX9804588A (es) | Uso de composiciones que comprenden blanqueador de halogeno para suavidad mejorada a la piel. | |
| MA22946A1 (fr) | Compositions de precurseurs d'agents de blanchiment. | |
| CA2181665A1 (en) | Synergistic stabilizer mixture | |
| AU8974298A (en) | 1,4,7,10-tetraazabicyclo{8.2.2}tetradecan-2-one, a process for the preparation thereof and the use thereof for the preparation of tetraazamacrocycles | |
| GB9712966D0 (en) | Novel chalcones | |
| IL111811A0 (en) | Conjugates of hirudin and lipophilic compounds | |
| IN225379B (el) | ||
| AU4706293A (en) | Therapeutic use of phosphoryl-l-serine-n-acyl-sphingosine | |
| TW344650B (en) | Fungicidal compositions and the process for the preparation thereof | |
| CA2182148A1 (en) | Process for the preparation of substituted aminocarbonyltriazolinones | |
| IL113899A0 (en) | Fungicidal compositions and their uses | |
| IT1242475B (it) | Agente colinergico, in particolare glicil-p-ammino-piridina-anilide- monoacetato, per il trattamento degli stati di demenza senile. | |
| CA2032311A1 (en) | 2,19-methyleneoxy and 2,19-methylenethio bridged steroids as aromatase and 19-hydroxylase inhibitors | |
| UA19097A (uk) | D-1-ФЕHІЛ-2-МЕТИЛАМІHОПРОПАHОЛА 1-5,6,7-ТРИОКСИФЛАВОH-7-0-beta-D-ГЛЮКУРОHИДАТ, ЩО МАЄ ОКИСЛЮВАЛЬHУ ДІЮ ТА РОЗШИРЮЄ СУДИHИ | |
| UA30250A (uk) | Антиоксидантний засіб |