ES2163487T3 - Conjugados de hirudina a partir de hirudina y compuestos lipofilos. - Google Patents

Conjugados de hirudina a partir de hirudina y compuestos lipofilos.

Info

Publication number
ES2163487T3
ES2163487T3 ES95901432T ES95901432T ES2163487T3 ES 2163487 T3 ES2163487 T3 ES 2163487T3 ES 95901432 T ES95901432 T ES 95901432T ES 95901432 T ES95901432 T ES 95901432T ES 2163487 T3 ES2163487 T3 ES 2163487T3
Authority
ES
Spain
Prior art keywords
hirudina
pct
compounds
hirudin
date
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95901432T
Other languages
English (en)
Inventor
Jurgen Schweden
Peter Eckes
Wilfried Hornberger
Thomas Subkowski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Application granted granted Critical
Publication of ES2163487T3 publication Critical patent/ES2163487T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Fats And Perfumes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Extrusion Moulding Of Plastics Or The Like (AREA)
  • Ink Jet (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Silicon Polymers (AREA)

Abstract

LA INVENCION TRATA DE NUEVOS CONJUGADOS DE HIRUDINA, FORMADOS A PARTIR DE UNA HIRUDINA Y UNO O MAS COMPUESTOS LIPOFILICOS, DONDE EL COMPUESTO LIPOFILICO POSEE UN COEFICIENTE DE REPARTO OCTANOL-AGUA DE MAS DE 1,8 Y ESTA UNIDO QUIMICAMENTE CON LA HIRUDINA, SU OBTENCION Y SU UTILIZACION.
ES95901432T 1993-12-02 1994-11-25 Conjugados de hirudina a partir de hirudina y compuestos lipofilos. Expired - Lifetime ES2163487T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4341115 1993-12-02
PCT/EP1994/003901 WO1995015183A1 (de) 1993-12-02 1994-11-25 Hirudin-konjugate aus hirudin und lipophilen verbindungen

Publications (1)

Publication Number Publication Date
ES2163487T3 true ES2163487T3 (es) 2002-02-01

Family

ID=6504029

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95901432T Expired - Lifetime ES2163487T3 (es) 1993-12-02 1994-11-25 Conjugados de hirudina a partir de hirudina y compuestos lipofilos.

Country Status (25)

Country Link
US (1) US5919762A (es)
EP (1) EP0730473B1 (es)
JP (1) JPH09505810A (es)
CN (1) CN1142776A (es)
AT (1) ATE204763T1 (es)
AU (1) AU679811B2 (es)
BR (1) BR9408195A (es)
CA (1) CA2176967A1 (es)
CZ (1) CZ157096A3 (es)
DE (2) DE4437502A1 (es)
DK (1) DK0730473T3 (es)
ES (1) ES2163487T3 (es)
FI (1) FI962299A0 (es)
GR (1) GR3036938T3 (es)
HR (1) HRP940968A2 (es)
HU (1) HUT74390A (es)
IL (1) IL111811A0 (es)
NO (1) NO962261L (es)
NZ (1) NZ276410A (es)
PL (1) PL314797A1 (es)
PT (1) PT730473E (es)
SG (1) SG49156A1 (es)
SK (1) SK67596A3 (es)
WO (1) WO1995015183A1 (es)
ZA (1) ZA949562B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4437604A1 (de) * 1994-10-21 1996-04-25 Basf Ag Konjugate aus einem Poly- oder Oligopeptid und einer niedermolekularen lipophilen Verbindung
US5726168A (en) * 1995-10-12 1998-03-10 Eli Lilly And Company Lipophilic benzothiophenes
DE19915862A1 (de) * 1999-04-08 2000-10-12 Max Planck Gesellschaft Verwendung von molekulargewichtserweitertem Hirudin als Antikoagulans bei der extrakorporalen Nierenersatztherapie
WO2003035167A2 (en) * 2001-10-24 2003-05-01 Power Paper Ltd Device and method for controlled delivery of active substance into the skin
US7438925B2 (en) * 2002-08-26 2008-10-21 Biovention Holdings Ltd. Drug eluting coatings for medical implants
BR102017005783A2 (pt) * 2017-03-21 2018-10-02 Fund Butantan processo de obtenção de esculptina e seus fragmentos, esculptina recombinante e seus usos
KR102366360B1 (ko) * 2021-06-29 2022-02-23 (주)네오팜 신규한 유사 세라마이드 화합물 및 이를 포함하는 피부 외용제 조성물

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0077529B1 (de) * 1981-10-16 1985-07-17 Sanol Schwarz GmbH Arzneimittelformulierung
DE3445532A1 (de) * 1984-12-13 1986-06-19 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Hirudin-pa, desulfatohirudine-pa, verfahren zur herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
US4939174A (en) * 1988-02-26 1990-07-03 Shashoua Victor E Appetite suppression with dopamine-fatty acid conjugates
DE3819079A1 (de) * 1988-06-04 1989-12-07 Hoechst Ag Hirudin-derivate mit verzoegerter wirkung
ES2055907T3 (es) * 1989-03-07 1994-09-01 Genentech Inc Conjugados covalentes de lipidos y oligonucleotidos.
CA2067224C (en) * 1989-12-01 2001-02-13 Manfred Kurfuerst Hirudin/polyalkylene glycol conjugates
DE4014260A1 (de) * 1989-12-01 1991-06-06 Basf Ag Hirudinpolyalkylenglykolkonjugate
WO1991009837A1 (en) * 1989-12-22 1991-07-11 Commonwealth Scientific And Industrial Research Organisation Amino acids, peptides or derivatives thereof coupled to fats
JPH05505941A (ja) * 1990-03-29 1993-09-02 ギリード　サイエンシズ　インコーポレーテッド オリゴヌクレオチド―輸送剤ジスルフィド結合体
US5256641A (en) * 1990-11-01 1993-10-26 State Of Oregon Covalent polar lipid-peptide conjugates for immunological targeting
WO1992019233A2 (en) * 1991-04-29 1992-11-12 Control Delivery Systems, Inc. Sustained release composition and methods of use thereof
AU1664892A (en) * 1991-05-02 1992-12-21 Pierre Baudet N-phenyl-cinnamamides providing protection from the harmful effects of ultraviolet light
US5359030A (en) * 1993-05-10 1994-10-25 Protein Delivery, Inc. Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same

Also Published As

Publication number Publication date
BR9408195A (pt) 1997-08-26
HUT74390A (en) 1996-12-30
NO962261D0 (no) 1996-05-31
SG49156A1 (en) 1998-05-18
EP0730473A1 (de) 1996-09-11
US5919762A (en) 1999-07-06
NO962261L (no) 1996-05-31
AU1067095A (en) 1995-06-19
PL314797A1 (en) 1996-09-30
HU9601471D0 (en) 1996-07-29
IL111811A0 (en) 1995-01-24
FI962299A (fi) 1996-05-31
WO1995015183A1 (de) 1995-06-08
DE4437502A1 (de) 1995-06-08
NZ276410A (en) 1997-03-24
FI962299A0 (fi) 1996-05-31
SK67596A3 (en) 1996-12-04
CN1142776A (zh) 1997-02-12
DE59409847D1 (de) 2001-10-04
DK0730473T3 (da) 2001-10-08
JPH09505810A (ja) 1997-06-10
CA2176967A1 (en) 1995-06-08
HRP940968A2 (en) 1997-08-31
ATE204763T1 (de) 2001-09-15
GR3036938T3 (en) 2002-01-31
AU679811B2 (en) 1997-07-10
EP0730473B1 (de) 2001-08-29
ZA949562B (en) 1996-06-03
CZ157096A3 (en) 1996-09-11
PT730473E (pt) 2002-02-28

Similar Documents

Publication Publication Date Title
DE69230144D1 (de) Röntgenkontrastmittel
DK0695171T3 (da) Lyosfærer indeholdende gonadotropin
BG102259A (en) Compostions with controlled paroxetine release
BG103485A (en) Ketobanzamides as calpain inhibitors
MX9501850A (es) Piridilpirazoles sustituidos, procedimiento para su obtencion y composiciones pesticidas y artropodicidas que los contienen.
MX9804588A (es) Uso de composiciones que comprenden blanqueador de halogeno para suavidad mejorada a la piel.
MA22946A1 (fr) Compositions de precurseurs d'agents de blanchiment.
IT1271325B (it) Composti diastereomericamente puri derivati da 3-oxo e 3-tioxo-4-azaandrostani e loro uso come antiandrogeni
AU8974298A (en) 1,4,7,10-tetraazabicyclo{8.2.2}tetradecan-2-one, a process for the preparation thereof and the use thereof for the preparation of tetraazamacrocycles
MX9709398A (es) N-aril-1,2,4-triazolin-5-onas.
DK0653912T3 (da) Spiringshæmmer for kartofler
ES2163487T3 (es) Conjugados de hirudina a partir de hirudina y compuestos lipofilos.
IT9047667A1 (it) Perfezionamento composizioni pozzolaniche.
FR2703244B1 (fr) ALPHArticle d'hygiène féminine tel qu'une serviette périodique.
MX9802105A (es) Composiciones estabilizadas suavizadoras de telas.
AR008474A1 (es) Derivado de 9-dihidroeritromicina a 6,9; 11,12-diciclocarbonato, composicion farmaceutica y preparacion bactericida que lo contienen y su uso
TW344650B (en) Fungicidal compositions and the process for the preparation thereof
CA2182148A1 (en) Process for the preparation of substituted aminocarbonyltriazolinones
IT1242475B (it) Agente colinergico, in particolare glicil-p-ammino-piridina-anilide- monoacetato, per il trattamento degli stati di demenza senile.
ES2185154T3 (es) Metodo de uso de inhibidores de la ciclooxigenasa-2 en el tratamiento y prevencion de la demencia.
UA19097A (uk) D-1-ФЕHІЛ-2-МЕТИЛАМІHОПРОПАHОЛА 1-5,6,7-ТРИОКСИФЛАВОH-7-0-beta-D-ГЛЮКУРОHИДАТ, ЩО МАЄ ОКИСЛЮВАЛЬHУ ДІЮ ТА РОЗШИРЮЄ СУДИHИ
KR960700053A (ko) 방사선회복제로서 리루졸의 이용(application of riluzole as a radiorestorer)
UA30250A (uk) Антиоксидантний засіб
UA20123A (uk) Засіб для профілактики рецидивів виразкової хвороби дваhадцятипалої кишки

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 730473

Country of ref document: ES