SK540290A3 - Parenterally applicable pharmaceutical composition containing bis-indole alkaloid and preparation method thereof - Google Patents

Parenterally applicable pharmaceutical composition containing bis-indole alkaloid and preparation method thereof Download PDF

Info

Publication number
SK540290A3
SK540290A3 SK5402-90A SK540290A SK540290A3 SK 540290 A3 SK540290 A3 SK 540290A3 SK 540290 A SK540290 A SK 540290A SK 540290 A3 SK540290 A3 SK 540290A3
Authority
SK
Slovakia
Prior art keywords
bis
pharmaceutical composition
zinc
hydroxybenzoate
indole alkaloid
Prior art date
Application number
SK5402-90A
Other languages
English (en)
Slovak (sk)
Other versions
SK278421B6 (en
Inventor
Maria Gazdag
Gabor Szepesi
Nagy Geza Takacsi
Sziklai Zsofia Papp
Laszlo Nagy
Bobjak Monika Zsoldos
Eva Eszter Kiss
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of SK540290A3 publication Critical patent/SK540290A3/sk
Publication of SK278421B6 publication Critical patent/SK278421B6/sk

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
SK5402-90A 1989-11-07 1990-11-02 Parenterally applicable pharmaceutical composition containing bis-indole alkaloid and preparation method thereof SK278421B6 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU895804A HU204995B (en) 1989-11-07 1989-11-07 Process for producing pharmaceutical composition comprising alkaloid with bis-indole skeleton, with antitumour activity and suitable fr parenteral purposes

Publications (2)

Publication Number Publication Date
SK540290A3 true SK540290A3 (en) 1997-05-07
SK278421B6 SK278421B6 (en) 1997-05-07

Family

ID=10970758

Family Applications (1)

Application Number Title Priority Date Filing Date
SK5402-90A SK278421B6 (en) 1989-11-07 1990-11-02 Parenterally applicable pharmaceutical composition containing bis-indole alkaloid and preparation method thereof

Country Status (37)

Country Link
US (1) US5397784A (de)
JP (1) JP3042702B2 (de)
KR (1) KR0164601B1 (de)
CN (1) CN1053569C (de)
AR (1) AR245592A1 (de)
AT (1) AT401469B (de)
AU (1) AU638504B2 (de)
BE (1) BE1004051A4 (de)
BG (1) BG60609B1 (de)
CA (1) CA2029368C (de)
CH (1) CH682130A5 (de)
CZ (1) CZ279433B6 (de)
DE (1) DE4035253B4 (de)
DK (1) DK266390A (de)
ES (1) ES2026062A6 (de)
FI (1) FI100455B (de)
FR (1) FR2653998B1 (de)
GB (1) GB2238241B (de)
GR (1) GR1001041B (de)
HU (1) HU204995B (de)
IE (1) IE62387B1 (de)
IL (1) IL96249A (de)
IT (1) IT1242724B (de)
LT (1) LT3334B (de)
LV (1) LV10687B (de)
MY (1) MY104595A (de)
NL (1) NL9002412A (de)
NO (1) NO175565C (de)
NZ (1) NZ236005A (de)
PL (1) PL164881B1 (de)
PT (1) PT95810B (de)
RU (1) RU1828401C (de)
SE (1) SE509715C2 (de)
SK (1) SK278421B6 (de)
UA (1) UA13162A (de)
YU (1) YU48373B (de)
ZA (1) ZA908855B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2385528C (en) 1999-10-01 2013-12-10 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
JP2002100303A (ja) * 2000-09-20 2002-04-05 Hitachi Ltd カラ−陰極線管
US20050170015A1 (en) * 2000-10-31 2005-08-04 Brown Dennis M. Antiproliferative colchicine compositions and uses thereof
FR2863891B1 (fr) * 2003-12-23 2006-03-24 Pf Medicament Composition pharmaceutique de vinflunine destinee a une administration parentale, procede de preparation et utilisation
US20110015221A1 (en) * 2003-12-23 2011-01-20 Pierre Fabre Medicament Pharmaceutical composition of vinflunine which is intended for parenteral administration preparation method thereof and use of same
US8512761B2 (en) 2006-01-27 2013-08-20 Yale University Fast acting inhibitor of gastric acid secretion
TWI678213B (zh) * 2015-07-22 2019-12-01 美商史倍壯製藥公司 用於長春新鹼硫酸鹽脂質體注射之即可使用的調配物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD155034A1 (de) * 1980-07-31 1982-05-12 Uwe Olthoff Verfahren zur herstellung stabiler kalziumhaltiger injektionsloesungen
IT1170152B (it) 1982-07-19 1987-06-03 Lilly Co Eli Miglioramenti a o riguardanti formulazioni di vinca-alcaloidi
US4619935A (en) * 1983-03-17 1986-10-28 Eli Lilly And Company Stable oncolytic formulations
HU195513B (en) * 1984-10-16 1988-05-30 Richter Gedeon Vegyeszet Process for producing stable solutions of alkaloides with bis-indole skeleton
FR2597750B1 (fr) * 1986-04-25 1989-06-02 Pf Medicament Solution aqueuse stable de sulfate de vincristine
IL83086A (en) * 1987-07-06 1991-03-10 Teva Pharma Stable,injectable solutions of vincristine salts
US4923876A (en) * 1988-04-18 1990-05-08 Cetus Corporation Vinca alkaloid pharmaceutical compositions

Also Published As

Publication number Publication date
MY104595A (en) 1994-04-30
KR910009245A (ko) 1991-06-28
YU48373B (sh) 1998-07-10
HU204995B (en) 1992-03-30
ES2026062A6 (es) 1992-04-01
NO175565C (no) 1994-11-02
NO904821D0 (no) 1990-11-06
HU895804D0 (en) 1990-01-28
NO904821L (no) 1991-05-08
AU6584590A (en) 1991-05-16
CZ279433B6 (cs) 1995-04-12
JPH03206040A (ja) 1991-09-09
GB2238241B (en) 1993-10-06
JP3042702B2 (ja) 2000-05-22
ZA908855B (en) 1991-08-28
ATA223090A (de) 1996-02-15
PL164881B1 (en) 1994-10-31
SK278421B6 (en) 1997-05-07
GR900100795A (en) 1992-04-17
NL9002412A (nl) 1991-06-03
SE509715C2 (sv) 1999-03-01
RU1828401C (ru) 1993-07-15
DE4035253A1 (de) 1991-05-08
PT95810A (pt) 1991-09-13
FI905508A0 (fi) 1990-11-07
DK266390A (da) 1991-05-08
CA2029368A1 (en) 1991-05-08
IT9067868A0 (it) 1990-11-06
AU638504B2 (en) 1993-07-01
KR0164601B1 (ko) 1999-01-15
IT1242724B (it) 1994-05-17
LT3334B (en) 1995-07-25
US5397784A (en) 1995-03-14
CN1053185A (zh) 1991-07-24
CH682130A5 (de) 1993-07-30
LV10687B (en) 1995-12-20
CN1053569C (zh) 2000-06-21
DE4035253B4 (de) 2004-10-07
SE9003523D0 (sv) 1990-11-06
NZ236005A (en) 1992-03-26
PT95810B (pt) 1997-11-28
LTIP512A (en) 1994-11-25
HUT55225A (en) 1991-05-28
AT401469B (de) 1996-09-25
DK266390D0 (da) 1990-11-06
BE1004051A4 (fr) 1992-09-15
GB9024222D0 (en) 1990-12-19
SE9003523L (sv) 1991-05-08
GR1001041B (el) 1993-03-31
LV10687A (lv) 1995-06-20
IE62387B1 (en) 1995-01-25
IL96249A0 (en) 1991-08-16
AR245592A1 (es) 1994-02-28
IT9067868A1 (it) 1992-05-06
CZ540290A3 (en) 1994-11-16
GB2238241A (en) 1991-05-29
CA2029368C (en) 2000-01-04
BG60609B1 (bg) 1995-10-31
FR2653998A1 (fr) 1991-05-10
IE903993A1 (en) 1991-05-08
FI100455B (fi) 1997-12-15
UA13162A (uk) 1997-02-28
YU209590A (sh) 1993-05-28
IL96249A (en) 1995-07-31
FR2653998B1 (fr) 1995-02-17
NO175565B (no) 1994-07-25

Similar Documents

Publication Publication Date Title
SU1482509A3 (ru) Способ стабилизации пироксикама
IE80461B1 (en) New compositions containing taxane derivatives
EP0143478A1 (de) Stabile, wässerige, saure, zur Einspritzung geeignete Lösung von Cis-Platinum
SK540290A3 (en) Parenterally applicable pharmaceutical composition containing bis-indole alkaloid and preparation method thereof
CA2405378C (en) Stable taurolidine electrolyte solutions
US5104896A (en) Carboplatin composition
US4883805A (en) Stable, Injectable solutions of vinca dimer salts
SK862004A3 (en) Liquid formulation comprising cetuximab and a fatty acid ester of polyoxyethylene sorbitan
CA1240930A (en) Process for producing an injection of nicardipine hydrochloride
WO2017179683A1 (ja) ミカファンギンの安定化された医薬組成物
AU613810B2 (en) Cisplatin hypertonic solution
HU211477A9 (hu) Bisz-indol-alkaloid-sót tartalmazó injekciós oldat
JPS5936616A (ja) セフアロスポリン誘導体の安定な医薬組成物
WO2024067094A1 (zh) 烯草酮组合物及含有该组合物的乳油和母药
KR100525058B1 (ko) 광안정성을 높인 수성 약제학적 조성물 및 광안정화 방법
KR20210101193A (ko) 이부프로펜 및 아르기닌을 함유하는 안정성이 개선된 주사용 제제