AR245592A1 - Procedimiento para la preparacion de una composicion farmaceutica parenteralmente util, conteniendo bisindol alcaloides que tienen actividad antitumoral. - Google Patents

Procedimiento para la preparacion de una composicion farmaceutica parenteralmente util, conteniendo bisindol alcaloides que tienen actividad antitumoral.

Info

Publication number
AR245592A1
AR245592A1 AR90318325A AR31832590A AR245592A1 AR 245592 A1 AR245592 A1 AR 245592A1 AR 90318325 A AR90318325 A AR 90318325A AR 31832590 A AR31832590 A AR 31832590A AR 245592 A1 AR245592 A1 AR 245592A1
Authority
AR
Argentina
Prior art keywords
indol
mass
aqueous solution
parts
zinc
Prior art date
Application number
AR90318325A
Other languages
English (en)
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Application granted granted Critical
Publication of AR245592A1 publication Critical patent/AR245592A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Press Drives And Press Lines (AREA)
  • Press-Shaping Or Shaping Using Conveyers (AREA)
  • Powder Metallurgy (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE UNA COMPOSICION FARMACEUTICA PARENTERALMENTE UTIL CONTENIENDO BIS-INDOL-ALCALOIDES QUE TIENEN ACTIVIDAD ANTITUMORAL, COMPRENDE DISOLVER EN AGUA UNA PARTE PORMASA DE SALES DE ADICION DE ACIDO DE VINCRISTINA, VINBLASTINA O 5'-NOR-ANHIDRIDOVINBLASTINA; MEZCLAR CON LA SOLUCION ACUOSA DE 0,2 A 0,5 PARTE POR MASA DE SULFATO DE ZINC; PONER EN CONTACTO EL COMPLEJO DE ALCALOIDE-ZINC RESULTANTE CON LA SOLUCION ACUOSA DE 1,0 A 2,0 PARTES POR MASA DE GLUCONATO DE CALCIO, ZINC O MAGNESIO Y SUPLEMENTAR LA SOLUCION ACUOSA RESULTANTE CON 20 A 50 PARTES PORMASA CALCULADO SOBRE EL BIS-INDOL, DE UNA SOLUCION QUE CONTIENE 0,2 A 1,5 PARTES POR MASA DE METILESTER DE ACIDO 4-HIDROXIBENZOICO Y/O PROPIELESTER DE ACIDO 4-HIDROXI-BENZOICO CALCULADO SOBRE ELBIS-INDOL, DISUELTO EN UN ALCANOL MONO O DIHIDRICO C2-5.
AR90318325A 1989-11-07 1990-11-07 Procedimiento para la preparacion de una composicion farmaceutica parenteralmente util, conteniendo bisindol alcaloides que tienen actividad antitumoral. AR245592A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU895804A HU204995B (en) 1989-11-07 1989-11-07 Process for producing pharmaceutical composition comprising alkaloid with bis-indole skeleton, with antitumour activity and suitable fr parenteral purposes

Publications (1)

Publication Number Publication Date
AR245592A1 true AR245592A1 (es) 1994-02-28

Family

ID=10970758

Family Applications (1)

Application Number Title Priority Date Filing Date
AR90318325A AR245592A1 (es) 1989-11-07 1990-11-07 Procedimiento para la preparacion de una composicion farmaceutica parenteralmente util, conteniendo bisindol alcaloides que tienen actividad antitumoral.

Country Status (37)

Country Link
US (1) US5397784A (es)
JP (1) JP3042702B2 (es)
KR (1) KR0164601B1 (es)
CN (1) CN1053569C (es)
AR (1) AR245592A1 (es)
AT (1) AT401469B (es)
AU (1) AU638504B2 (es)
BE (1) BE1004051A4 (es)
BG (1) BG60609B1 (es)
CA (1) CA2029368C (es)
CH (1) CH682130A5 (es)
CZ (1) CZ279433B6 (es)
DE (1) DE4035253B4 (es)
DK (1) DK266390A (es)
ES (1) ES2026062A6 (es)
FI (1) FI100455B (es)
FR (1) FR2653998B1 (es)
GB (1) GB2238241B (es)
GR (1) GR1001041B (es)
HU (1) HU204995B (es)
IE (1) IE62387B1 (es)
IL (1) IL96249A (es)
IT (1) IT1242724B (es)
LT (1) LT3334B (es)
LV (1) LV10687B (es)
MY (1) MY104595A (es)
NL (1) NL9002412A (es)
NO (1) NO175565C (es)
NZ (1) NZ236005A (es)
PL (1) PL164881B1 (es)
PT (1) PT95810B (es)
RU (1) RU1828401C (es)
SE (1) SE509715C2 (es)
SK (1) SK540290A3 (es)
UA (1) UA13162A (es)
YU (1) YU48373B (es)
ZA (1) ZA908855B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU775373B2 (en) 1999-10-01 2004-07-29 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
JP2002100303A (ja) * 2000-09-20 2002-04-05 Hitachi Ltd カラ−陰極線管
US20050170015A1 (en) * 2000-10-31 2005-08-04 Brown Dennis M. Antiproliferative colchicine compositions and uses thereof
FR2863891B1 (fr) * 2003-12-23 2006-03-24 Pf Medicament Composition pharmaceutique de vinflunine destinee a une administration parentale, procede de preparation et utilisation
US20110015221A1 (en) * 2003-12-23 2011-01-20 Pierre Fabre Medicament Pharmaceutical composition of vinflunine which is intended for parenteral administration preparation method thereof and use of same
US8512761B2 (en) * 2006-01-27 2013-08-20 Yale University Fast acting inhibitor of gastric acid secretion
TWI678213B (zh) * 2015-07-22 2019-12-01 美商史倍壯製藥公司 用於長春新鹼硫酸鹽脂質體注射之即可使用的調配物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD155034A1 (de) * 1980-07-31 1982-05-12 Uwe Olthoff Verfahren zur herstellung stabiler kalziumhaltiger injektionsloesungen
IT1170152B (it) * 1982-07-19 1987-06-03 Lilly Co Eli Miglioramenti a o riguardanti formulazioni di vinca-alcaloidi
US4619935A (en) * 1983-03-17 1986-10-28 Eli Lilly And Company Stable oncolytic formulations
HU195513B (en) * 1984-10-16 1988-05-30 Richter Gedeon Vegyeszet Process for producing stable solutions of alkaloides with bis-indole skeleton
FR2597750B1 (fr) * 1986-04-25 1989-06-02 Pf Medicament Solution aqueuse stable de sulfate de vincristine
IL83086A (en) * 1987-07-06 1991-03-10 Teva Pharma Stable,injectable solutions of vincristine salts
US4923876A (en) * 1988-04-18 1990-05-08 Cetus Corporation Vinca alkaloid pharmaceutical compositions

Also Published As

Publication number Publication date
SE509715C2 (sv) 1999-03-01
AU6584590A (en) 1991-05-16
SK278421B6 (en) 1997-05-07
GB2238241A (en) 1991-05-29
MY104595A (en) 1994-04-30
CZ540290A3 (en) 1994-11-16
UA13162A (uk) 1997-02-28
KR0164601B1 (ko) 1999-01-15
GB9024222D0 (en) 1990-12-19
IT9067868A1 (it) 1992-05-06
HUT55225A (en) 1991-05-28
CA2029368A1 (en) 1991-05-08
IE62387B1 (en) 1995-01-25
CA2029368C (en) 2000-01-04
ATA223090A (de) 1996-02-15
HU204995B (en) 1992-03-30
NO175565C (no) 1994-11-02
LV10687A (lv) 1995-06-20
FR2653998A1 (fr) 1991-05-10
LTIP512A (en) 1994-11-25
FI905508A0 (fi) 1990-11-07
NO904821D0 (no) 1990-11-06
BG93175A (bg) 1993-12-24
GR900100795A (en) 1992-04-17
IL96249A (en) 1995-07-31
LT3334B (en) 1995-07-25
HU895804D0 (en) 1990-01-28
YU209590A (sh) 1993-05-28
SK540290A3 (en) 1997-05-07
SE9003523D0 (sv) 1990-11-06
JP3042702B2 (ja) 2000-05-22
NO175565B (no) 1994-07-25
DE4035253B4 (de) 2004-10-07
FI100455B (fi) 1997-12-15
YU48373B (sh) 1998-07-10
IT9067868A0 (it) 1990-11-06
AT401469B (de) 1996-09-25
DE4035253A1 (de) 1991-05-08
BE1004051A4 (fr) 1992-09-15
PL164881B1 (en) 1994-10-31
JPH03206040A (ja) 1991-09-09
ES2026062A6 (es) 1992-04-01
DK266390D0 (da) 1990-11-06
DK266390A (da) 1991-05-08
SE9003523L (sv) 1991-05-08
GR1001041B (el) 1993-03-31
BG60609B1 (bg) 1995-10-31
KR910009245A (ko) 1991-06-28
US5397784A (en) 1995-03-14
IE903993A1 (en) 1991-05-08
LV10687B (en) 1995-12-20
CN1053569C (zh) 2000-06-21
RU1828401C (ru) 1993-07-15
CN1053185A (zh) 1991-07-24
ZA908855B (en) 1991-08-28
IT1242724B (it) 1994-05-17
IL96249A0 (en) 1991-08-16
AU638504B2 (en) 1993-07-01
NL9002412A (nl) 1991-06-03
PT95810A (pt) 1991-09-13
NZ236005A (en) 1992-03-26
PT95810B (pt) 1997-11-28
GB2238241B (en) 1993-10-06
NO904821L (no) 1991-05-08
CH682130A5 (es) 1993-07-30
CZ279433B6 (cs) 1995-04-12
FR2653998B1 (fr) 1995-02-17

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