SK4322003A3 - Aza- and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors - Google Patents

Aza- and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors Download PDF

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Publication number
SK4322003A3
SK4322003A3 SK432-2003A SK4322003A SK4322003A3 SK 4322003 A3 SK4322003 A3 SK 4322003A3 SK 4322003 A SK4322003 A SK 4322003A SK 4322003 A3 SK4322003 A3 SK 4322003A3
Authority
SK
Slovakia
Prior art keywords
alkyl
fluoroalkyl
substituted
hydroxy
halogen
Prior art date
Application number
SK432-2003A
Other languages
English (en)
Slovak (sk)
Inventor
Neville J Anthony
Robert P Gomez
Steven D Young
Melissa Egbertson
John S Wai
Linghang Zhuang
Mark Embrey
Lekhanh Tran
Jeffrey Y Melamed
Marie H Langford
James P Guare
Thorsten E Fisher
Samson M Jolly
Michelle KUO
Debra S Perlow
Jennifer J Bennett
Timothy W Funk
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of SK4322003A3 publication Critical patent/SK4322003A3/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SK432-2003A 2000-10-12 2001-10-09 Aza- and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors SK4322003A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23970700P 2000-10-12 2000-10-12
US28165601P 2001-04-05 2001-04-05
PCT/US2001/042564 WO2002030931A2 (en) 2000-10-12 2001-10-09 Aza- and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors

Publications (1)

Publication Number Publication Date
SK4322003A3 true SK4322003A3 (en) 2003-09-11

Family

ID=26932782

Family Applications (1)

Application Number Title Priority Date Filing Date
SK432-2003A SK4322003A3 (en) 2000-10-12 2001-10-09 Aza- and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors

Country Status (26)

Country Link
US (2) US6921759B2 (xx)
EP (1) EP1326865B1 (xx)
JP (1) JP4252797B2 (xx)
KR (1) KR20030036922A (xx)
CN (1) CN1469878A (xx)
AR (1) AR033845A1 (xx)
AT (1) ATE430745T1 (xx)
AU (3) AU1152702A (xx)
BG (1) BG107677A (xx)
BR (1) BR0114610A (xx)
CA (1) CA2425440C (xx)
CZ (1) CZ20031028A3 (xx)
DE (1) DE60138635D1 (xx)
EA (1) EA200300449A1 (xx)
EE (1) EE200300145A (xx)
HU (1) HUP0302367A2 (xx)
IL (1) IL155089A0 (xx)
IS (1) IS6760A (xx)
MX (1) MXPA03003263A (xx)
NO (1) NO20031672L (xx)
NZ (1) NZ525088A (xx)
PE (1) PE20020509A1 (xx)
PL (1) PL360944A1 (xx)
SK (1) SK4322003A3 (xx)
WO (2) WO2002030931A2 (xx)
YU (1) YU27903A (xx)

Families Citing this family (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA200300449A1 (ru) * 2000-10-12 2003-10-30 Мерк Энд Ко., Инк. Аза- и полиаза-нафталинилкарбоксамиды, полезные в качестве ингибиторов вич-интегразы
TWI243164B (en) 2001-02-13 2005-11-11 Aventis Pharma Gmbh Acylated indanyl amines and their use as pharmaceuticals
BR0207809A (pt) 2001-03-01 2004-03-09 Shionogi & Co Compostos heteroarila contendo nitrogênio possuindo atividade inibidora contra integrase de hiv
DK2266958T1 (da) 2001-08-10 2016-04-04 Shionogi & Co Antiviralt middel
JP2005504770A (ja) * 2001-08-17 2005-02-17 メルク　エンド　カムパニー　インコーポレーテッド ５−スルホンアミド−８−ヒドロキシ−１，６−ナフチリジン−７−カルボキサミドの製造方法
US20040186093A1 (en) * 2001-08-17 2004-09-23 Jaemoon Lee Process for preparing sultams
AR036256A1 (es) * 2001-08-17 2004-08-25 Merck & Co Inc Sal sodica de un inhibidor de integrasa del vih, procesos para su preparacion, composiciones farmaceuticas que lo contienen y su uso para la manufactura de un medicamento
MXPA04003932A (es) * 2001-10-26 2004-06-18 Angeletti P Ist Richerche Bio Inhibidores de la hidroxipirimidinona carboxamida n-sustituida de la integrasa del virus de inmunodeficiencia humana.
WO2003035076A1 (en) 2001-10-26 2003-05-01 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Dihydroxypyrimidine carboxamide inhibitors of hiv integrase
DE10155075A1 (de) 2001-11-09 2003-05-22 Merck Patent Gmbh Cyclische Sulfonamide
CA2472372C (en) 2002-01-17 2010-08-17 Melissa Egbertson Hydroxynaphthyridinone carboxamides useful as hiv integrase inhibitors
DE60323743D1 (en) * 2002-03-15 2008-11-06 Merck & Co Inc N-(substituierte benzyl)-8-hydroxy-1,6-naphthyridin-7- carbonsäureamide als hiv-integrase-hemmer
AU2003220186A1 (en) * 2002-04-10 2003-10-27 Merck And Co., Inc. Pharmaceutical compositions containing an hiv integrase inhibitor and a nonionic surfactant
US7109233B2 (en) * 2002-05-22 2006-09-19 Smithkline Beecham Corporation Protease inhibitors
EP1388535A1 (en) * 2002-08-07 2004-02-11 Aventis Pharma Deutschland GmbH Acylated arylcycloalkylamines and their use as pharmaceuticals
US7358249B2 (en) 2002-08-13 2008-04-15 Shionogi & Co., Ltd. Heterocyclic compounds having inhibitory activity against HIV integrase
CA2498111A1 (en) 2002-09-11 2004-03-25 Merck & Co., Inc. Dihydroxypyridopyrazine-1,6-dione compounds useful as hiv integrase inhibitors
CA2498566A1 (en) 2002-09-11 2004-06-10 Merck & Co., Inc. 8-hydroxy-1-oxo-tetrahydropyrrolopyrazine compounds useful as hiv integrase inhibitors
US7692011B2 (en) 2002-10-04 2010-04-06 Prana Biotechnology Limited 8-hydroxy and 8-mercapto quinazolinones
EP1558581A4 (en) 2002-10-07 2007-07-25 Bristol Myers Squibb Co DERIVATIVES OF TRIAZOLONE AND TRIAZOLETHIONE
WO2004035577A2 (en) * 2002-10-16 2004-04-29 Gilead Sciences, Inc. Pre-organized tricyclic integrase inhibitor compounds
EP1578748B1 (en) 2002-12-27 2010-09-15 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Tetrahydro-4h-pyrido[1,2-a]pyrimidines and related compounds useful as hiv integrase inhibitors
US20060211687A1 (en) * 2003-03-12 2006-09-21 Michael Palucki Potassium salt of an hiv integrase inhibitor
US20040220273A1 (en) * 2003-03-12 2004-11-04 Jaemoon Lee Preparation of 2-aminomethyl-5-fluorobenzamides
US7812016B2 (en) 2003-05-13 2010-10-12 Smithkline Beecham Corporation Naphthyridine integrase inhibitors
JP2007523870A (ja) * 2003-07-15 2007-08-23 メルク　エンド　カムパニー　インコーポレーテッド ヒドロキシピリジンｃｇｒｐ受容体拮抗薬
TW200510425A (en) 2003-08-13 2005-03-16 Japan Tobacco Inc Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
EP1664046B1 (en) 2003-09-19 2009-06-17 Gilead Sciences, Inc. Aza-quinolinol phosphonate integrase inhibitor compounds
JP2007509149A (ja) 2003-10-20 2007-04-12 メルク　エンド　カムパニー　インコーポレーテッド Ｈｉｖインテグラーゼ阻害薬として有用なヒドロキシピリドピロロピラジンジオン化合物
TW200533357A (en) 2004-01-08 2005-10-16 Millennium Pharm Inc 2-(amino-substituted)-4-aryl pyrimidines and related compounds useful for treating inflammatory diseases
AU2005211349A1 (en) * 2004-01-30 2005-08-18 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. N-benzyl-3,4-dihyroxypyridine-2-carboxamide and N-benzyl-2,3-dihydroxypyridine-4-carboxamide compounds useful as HIV integrase inhibitors
US7919623B2 (en) 2004-02-04 2011-04-05 Shionogi & Co., Ltd. Naphthyridine derivatives having inhibitory activity against HIV integrase
BRPI0507628A (pt) 2004-02-11 2007-07-03 Smithkline Beecham Corp composto ou sal farmaceuticamente aceitável do mesmo, método de tratamento de uma infecção viral em um ser humano, uso de um composto composição farmacêutica, e, processo para a preparação de um composto
EP1725554A1 (en) 2004-03-09 2006-11-29 Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. Hiv integrase inhibitors
WO2005086700A2 (en) * 2004-03-09 2005-09-22 Merck & Co., Inc. Hiv integrase inhibitors
JP2007528394A (ja) * 2004-03-09 2007-10-11 メルク　エンド　カムパニー　インコーポレーテッド Ｈｉｖインテグラーゼ阻害薬
WO2005087768A1 (en) * 2004-03-09 2005-09-22 Merck & Co., Inc. Hiv integrase inhibitors
EP1756114B1 (en) 2004-05-07 2014-11-19 Merck Sharp & Dohme Corp. Hiv integrase inhibitors
WO2005120516A2 (en) * 2004-06-09 2005-12-22 Merck & Co., Inc. Hiv integrase inhibitors
JP2008521934A (ja) * 2004-12-03 2008-06-26 メルク エンド カムパニー インコーポレーテッド Ｕｇｔ１ａ１によって代謝される薬物の薬物動態を改善するためのアタザナビルの使用
UA87884C2 (uk) 2004-12-03 2009-08-25 Мерк Энд Ко., Инк. Безводна кристалічна калієва сіль інгібітора віл-інтегрази
US7858788B2 (en) * 2005-02-21 2010-12-28 Shionogi & Co., Ltd. Bicyclic carbamoylpyridone derivative having HIV integrase inhibitory activity
EP1866313A1 (en) * 2005-03-31 2007-12-19 Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. Hiv integrase inhibitors
CA2607151C (en) 2005-05-10 2012-06-19 Merck & Co., Inc. Hiv integrase inhibitors
US20070072831A1 (en) * 2005-05-16 2007-03-29 Gilead Sciences, Inc. Integrase inhibitor compounds
JP2009503089A (ja) * 2005-08-04 2009-01-29 スミスクライン ビーチャム コーポレーション Ｈｉｖインテグラーゼ阻害薬
WO2007019101A2 (en) * 2005-08-04 2007-02-15 Smithkline Beecham Corporation Hiv integrase inhibitors
EP1910355A4 (en) * 2005-08-04 2010-11-24 Glaxosmithkline Llc HIV integrase
WO2007019098A2 (en) * 2005-08-04 2007-02-15 Smithkline Beecham Corporation Hiv integrase inhibitors
CA2622639C (en) * 2005-10-04 2012-01-03 Istituto Di Recerche Di Biologia Molecolare P. Angeletti S.P.A. Hiv integrase inhibitors
TW200800988A (en) 2005-10-27 2008-01-01 Shionogi & Amp Co Ltd Polycyclic carbamoylpyridone derivative having HIV integrase inhibitory activity
AU2006306355A1 (en) * 2005-10-27 2007-05-03 Merck & Co., Inc. HIV integrase inhibitors
CA2633760A1 (en) * 2005-12-21 2007-07-05 Abbott Laboratories Anti-viral compounds
EP2066670A2 (en) 2006-05-16 2009-06-10 Gilead Sciences, Inc. Integrase inhibitors
AU2007275816A1 (en) * 2006-07-17 2008-01-24 Merck Sharp & Dohme Corp. 1-hydroxy naphthyridine compounds as anti-HIV agents
EP2079699A1 (en) * 2006-07-25 2009-07-22 Envivo Pharmaceuticals, Inc. Quinoline derivatives
US8143447B2 (en) * 2006-09-05 2012-03-27 Bipar Sciences, Inc. Treatment of cancer
MX2009003410A (es) 2006-09-29 2009-07-17 Idenix Pharmaceuticals Inc Fosfoindoles enantiomericamente puros como inhibidores de vih.
AU2007313293A1 (en) * 2006-10-18 2008-04-24 Merck & Co., Inc. HIV integrase inhibitors
US20090291921A1 (en) * 2007-11-20 2009-11-26 Gilead Sciences, Inc. Integrase inhibitors
CA2713105C (en) 2008-01-25 2016-06-07 Chimerix, Inc. Methods of treating viral infections
CA2999321A1 (en) 2008-07-17 2010-01-21 Critical Outcome Technologies Inc. Thiosemicarbazone inhibitor compounds and cancer treatment methods
JP2012513464A (ja) 2008-12-23 2012-06-14 ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク ホスホジエステラーゼ阻害剤及びその使用
JP2012528160A (ja) 2009-05-27 2012-11-12 メルク・シャープ・エンド・ドーム・コーポレイション Ｈｉｖプロテアーゼ阻害薬
CN102574854B (zh) 2009-10-13 2014-04-16 伊兰科动物健康爱尔兰有限公司 大环整合酶抑制剂
CA2777937C (en) 2009-10-26 2017-08-29 Merck Sharp & Dohme Corp. Solid pharmaceutical compositions containing an integrase inhibitor
EP2345641A1 (en) 2009-12-29 2011-07-20 Polichem S.A. New secondary 8-hydroxyquinoline-7-carboxamide derivatives
EP2345642A1 (en) 2009-12-29 2011-07-20 Polichem S.A. Secondary 8-hydroxyquinoline-7-carboxamide derivatives for use as antifungal agents
EP2345643A1 (en) 2009-12-29 2011-07-20 Polichem S.A. New tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof
ES2629165T3 (es) 2010-02-12 2017-08-07 Chimerix, Inc. Métodos de tratamiento de una infección vírica
US8987272B2 (en) 2010-04-01 2015-03-24 Critical Outcome Technologies Inc. Compounds and method for treatment of HIV
RU2567385C2 (ru) 2010-04-02 2015-11-10 ЯНССЕН Ар ЭНД Ди АЙРЛЭНД Макроциклические ингибиторы интегразы
WO2012055031A1 (en) 2010-10-28 2012-05-03 Merck Canada Inc. Hiv protease inhibitors
EP2661265B1 (en) * 2010-12-23 2017-03-08 Merck Sharp & Dohme Corp. Quinolines and aza-quinolines as crth2 receptor modulators
AU2011349524B2 (en) 2010-12-23 2016-06-02 Merck Sharp & Dohme Corp. Quinoxalines and aza-quinoxalines as CRTH2 receptor modulators
EP2487176A1 (en) * 2011-02-14 2012-08-15 Elanco Animal Health Ireland Limited Macrocyclic integrase inhibitors for use in the treatment of feline immunodeficiency virus
CN107540599B (zh) 2011-02-18 2021-06-04 阿萨纳生物科技有限责任公司 氨基茚满化合物及其治疗疼痛的用途
EP2771332B1 (en) 2011-10-26 2016-06-29 Merck Canada Inc. Thiophen and thiazol sulfonamid derivatives as HIV protease inhibitors for the treatment of AIDS
US9044482B2 (en) 2012-08-15 2015-06-02 Asana Biosciences, Llc Use of aminoindane compounds in treating overactive bladder and interstitial cystitis
CN104755475B (zh) 2012-09-11 2016-12-28 默沙东公司 Hiv蛋白酶抑制剂
CN103709162B (zh) * 2012-09-29 2016-12-07 中国科学院上海药物研究所 三取代咪唑并二氮杂萘酮化合物及其制备方法和用途
CN104003986B (zh) * 2013-02-22 2016-06-08 中国科学院上海药物研究所 吡啶骈环类化合物及其制备方法、其药物组合物和用途
WO2015013835A1 (en) 2013-07-31 2015-02-05 Merck Sharp & Dohme Corp. Piperazine derivatives as hiv protease inhibitors
WO2015095276A1 (en) 2013-12-19 2015-06-25 Merck Sharp & Dohme Corp. Hiv protease inhibitors
WO2015095265A1 (en) 2013-12-19 2015-06-25 Merck Sharp & Dohme Corp. Hiv protease inhibitors
WO2015134366A1 (en) 2014-03-06 2015-09-11 Merck Sharp & Dohme Corp. Hiv protease inhibitors
WO2015138220A1 (en) 2014-03-10 2015-09-17 Merck Sharp & Dohme Corp. Piperazine derivatives as hiv protease inhibitors
CN109069440A (zh) 2016-03-02 2018-12-21 得克萨斯州大学系统董事会 用于免疫治疗的激活sting的纳米疫苗
CN106588922B (zh) * 2017-01-17 2018-04-27 北京工业大学 二取代八氢-1,6-萘啶类化合物及其制备方法和应用
AU2018302026B2 (en) * 2017-07-18 2022-04-07 Merck Patent Gmbh TLR7/8 antagonists and uses thereof
CN109776415B (zh) * 2019-03-07 2020-11-17 福建南方制药股份有限公司 一种Roxadustat中间体的制备方法
CN115710249A (zh) * 2022-11-14 2023-02-24 广东工业大学 一种多取代异喹啉和1,6-萘啶化合物的制备方法及光电材料常见分子骨架

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5751837B2 (xx) 1973-04-05 1982-11-04
US4416884A (en) 1978-04-12 1983-11-22 Otsuka Pharmaceutical Co., Ltd. Piperazinylbenzoheterocyclic compounds
FR2632639B1 (fr) 1988-06-09 1990-10-05 Sanofi Sa Derives d'amino-4 carboxy-3 naphtyridines, leur preparation et compositions pharmaceutiques qui les contiennent
AU1625192A (en) 1991-05-31 1992-12-03 Zeneca Limited Heterocyclic derivatives
US5681832A (en) * 1995-02-17 1997-10-28 The United States Of America As Represented By The Department Of Health And Human Services Aroylaniline compounds, pharmaceutical compositions, and methods of using same to inhibit viral activity
US5633362A (en) 1995-05-12 1997-05-27 E. I. Du Pont De Nemours And Company Production of 1,3-propanediol from glycerol by recombinant bacteria expressing recombinant diol dehydratase
AU695132B2 (en) 1995-08-02 1998-08-06 Darwin Discovery Limited Quinolones and their therapeutic use
US5945431A (en) 1996-03-15 1999-08-31 Biochem Therapeutics Incorporated Cytomegalovirus inhibiting compounds
CA2262786A1 (en) * 1996-09-10 1998-03-19 Pharmacia & Upjohn Company 8-hydroxy-7-substituted quinolines as anti-viral agents
WO1998013350A1 (en) 1996-09-25 1998-04-02 Zeneca Limited Qinoline derivatives inhibiting the effect of growth factors such as vegf
US5766944A (en) 1996-12-31 1998-06-16 Ruiz; Margaret Eileen T cell differentiation of CD34+ stem cells in cultured thymic epithelial fragments
US6294547B1 (en) 1997-06-30 2001-09-25 Nippon Kayaku Kabushiki Kaisha Naphthyridine deratives or salts thereof
JP2001514181A (ja) 1997-08-25 2001-09-11 ニューロゲン コーポレイション Ｇａｂａ脳レセプタリガンドとしての置換４−オキソ−ナフチリジン−３−カルボキサミド
GB9720052D0 (en) 1997-09-19 1997-11-19 Smithkline Beecham Plc Novel compounds
KR20010015639A (ko) 1997-09-30 2001-02-26 스즈키 다다시 술포닐 유도체
US6093732A (en) 1997-12-22 2000-07-25 Pharmacia & Upjohn Company 4-hydroxyquinoline-3-carboxamides and hydrazides as antiviral agents
US6380249B1 (en) 1998-06-03 2002-04-30 Merck & Co., Inc. HIV integrase inhibitors
US6306891B1 (en) 1998-06-03 2001-10-23 Merck & Co., Inc. HIV integrase inhibitors
US6262055B1 (en) 1998-06-03 2001-07-17 Merck & Co., Inc. HIV integrase inhibitors
SE9802550D0 (sv) 1998-07-15 1998-07-15 Active Biotech Ab Quinoline derivatives
CA2370500A1 (en) 1999-06-25 2001-01-04 Lekhanh O. Tran 1-(aromatic- or heteroaromatic-substituted)-3-(heteroaromatic substituted)-1,3-propanediones and uses thereof
US6730682B2 (en) 2000-07-12 2004-05-04 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
GB0017676D0 (en) 2000-07-19 2000-09-06 Angeletti P Ist Richerche Bio Inhibitors of viral polymerase
EA200300449A1 (ru) * 2000-10-12 2003-10-30 Мерк Энд Ко., Инк. Аза- и полиаза-нафталинилкарбоксамиды, полезные в качестве ингибиторов вич-интегразы
CN1336363A (zh) 2001-07-25 2002-02-20 张元宾 乙酰磺胺酸钾的合成制备方法
AR036256A1 (es) * 2001-08-17 2004-08-25 Merck & Co Inc Sal sodica de un inhibidor de integrasa del vih, procesos para su preparacion, composiciones farmaceuticas que lo contienen y su uso para la manufactura de un medicamento
JP2005504770A (ja) 2001-08-17 2005-02-17 メルク　エンド　カムパニー　インコーポレーテッド ５−スルホンアミド−８−ヒドロキシ−１，６−ナフチリジン−７−カルボキサミドの製造方法
WO2003035076A1 (en) 2001-10-26 2003-05-01 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Dihydroxypyrimidine carboxamide inhibitors of hiv integrase
MXPA04003932A (es) 2001-10-26 2004-06-18 Angeletti P Ist Richerche Bio Inhibidores de la hidroxipirimidinona carboxamida n-sustituida de la integrasa del virus de inmunodeficiencia humana.
AU2003220186A1 (en) * 2002-04-10 2003-10-27 Merck And Co., Inc. Pharmaceutical compositions containing an hiv integrase inhibitor and a nonionic surfactant

Also Published As

Publication number Publication date
CZ20031028A3 (cs) 2003-08-13
WO2002030931A3 (en) 2002-10-24
CA2425440C (en) 2010-04-13
MXPA03003263A (es) 2003-06-06
US6921759B2 (en) 2005-07-26
NO20031672L (no) 2003-06-05
KR20030036922A (ko) 2003-05-09
EP1326865A2 (en) 2003-07-16
EA200300449A1 (ru) 2003-10-30
WO2002030930A3 (en) 2002-08-29
IS6760A (is) 2003-03-27
NO20031672D0 (no) 2003-04-11
WO2002030930A2 (en) 2002-04-18
PL360944A1 (en) 2004-09-20
JP2004511483A (ja) 2004-04-15
AU2002211527B2 (en) 2006-08-24
US20030055071A1 (en) 2003-03-20
AR033845A1 (es) 2004-01-07
JP4252797B2 (ja) 2009-04-08
PE20020509A1 (es) 2002-06-20
NZ525088A (en) 2004-11-26
YU27903A (sh) 2006-05-25
WO2002030931A2 (en) 2002-04-18
ATE430745T1 (de) 2009-05-15
US20050176718A1 (en) 2005-08-11
HUP0302367A2 (hu) 2003-11-28
CA2425440A1 (en) 2002-04-18
AU1152702A (en) 2002-04-22
AU2002211874A1 (en) 2002-04-22
CN1469878A (zh) 2004-01-21
EP1326865B1 (en) 2009-05-06
BR0114610A (pt) 2005-12-13
EE200300145A (et) 2003-06-16
IL155089A0 (en) 2003-10-31
DE60138635D1 (de) 2009-06-18
BG107677A (bg) 2003-11-28

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