SK4282001A3 - Imidazo[4,5-c]pyridine-4-one derivative with factor xy inhibiting effect, method for its preparation, its use and pharmaceutical composition comprising same - Google Patents

Imidazo[4,5-c]pyridine-4-one derivative with factor xy inhibiting effect, method for its preparation, its use and pharmaceutical composition comprising same Download PDF

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Publication number
SK4282001A3
SK4282001A3 SK428-2001A SK4282001A SK4282001A3 SK 4282001 A3 SK4282001 A3 SK 4282001A3 SK 4282001 A SK4282001 A SK 4282001A SK 4282001 A3 SK4282001 A3 SK 4282001A3
Authority
SK
Slovakia
Prior art keywords
group
pyridin
formula
ylmethyl
isopropyl
Prior art date
Application number
SK428-2001A
Other languages
English (en)
Slovak (sk)
Inventor
Werner Mederski
Horst Juraszyk
Hanns Wurziger
Joachim Gante
Dieter Dorsch
Hans-Peter Buchstaller
Sabine Bernotat-Danielowski
Guido Melzer
Soheila Anzali
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of SK4282001A3 publication Critical patent/SK4282001A3/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
SK428-2001A 1998-10-01 1999-09-09 Imidazo[4,5-c]pyridine-4-one derivative with factor xy inhibiting effect, method for its preparation, its use and pharmaceutical composition comprising same SK4282001A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19845153A DE19845153A1 (de) 1998-10-01 1998-10-01 Imidazo[4,5]-pyridin-4-on-derivate
PCT/EP1999/006655 WO2000020416A1 (de) 1998-10-01 1999-09-09 Imidazo[4,5-c-]-pyridin-4-on-derivate mit faktor xa hemmender wirkung

Publications (1)

Publication Number Publication Date
SK4282001A3 true SK4282001A3 (en) 2002-10-08

Family

ID=7883005

Family Applications (1)

Application Number Title Priority Date Filing Date
SK428-2001A SK4282001A3 (en) 1998-10-01 1999-09-09 Imidazo[4,5-c]pyridine-4-one derivative with factor xy inhibiting effect, method for its preparation, its use and pharmaceutical composition comprising same

Country Status (18)

Country Link
US (1) US6492384B1 (de)
EP (1) EP1117664A1 (de)
JP (1) JP2002526542A (de)
KR (1) KR20010074980A (de)
CN (1) CN1324358A (de)
AR (1) AR020688A1 (de)
AU (1) AU752574B2 (de)
BR (1) BR9914213A (de)
CA (1) CA2346033A1 (de)
DE (1) DE19845153A1 (de)
HU (1) HUP0104164A3 (de)
ID (1) ID29466A (de)
MY (1) MY130736A (de)
NO (1) NO20011638D0 (de)
PL (1) PL346542A1 (de)
SK (1) SK4282001A3 (de)
WO (1) WO2000020416A1 (de)
ZA (1) ZA200103498B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1140941T3 (da) 1998-12-23 2005-02-14 Bristol Myers Squibb Pharma Co Nitrogenholdige heterobicykliske forbindelser som faktor Xa-inhibitorer
US6858616B2 (en) 1998-12-23 2005-02-22 Bristol-Myers Squibb Pharma Company Nitrogen containing heterobicycles as factor Xa inhibitors
AU2001268712A1 (en) 2000-06-23 2002-01-08 Bristol-Myers Squibb Company 1 - (heteroaryl-phenyl) - condensed pyrazol derivatives as factor Xa inhibitors
AU2002310070A1 (en) 2001-05-22 2002-12-03 Bristol-Myers Squibb Company Bicyclic inhibitors of factor xa
AU2003210958A1 (en) * 2002-02-08 2003-09-02 Glsynthesis Inc. Purine and isosteric antibacterial compounds
GB0215293D0 (en) * 2002-07-03 2002-08-14 Rega Foundation Viral inhibitors
DK1569912T3 (en) 2002-12-03 2015-06-29 Pharmacyclics Inc 2- (2-hydroxybiphenyl-3-yl) -1h-benzoimidazole-5-carboxamidine derivatives as factor VIIa inhibitors.
US7135469B2 (en) * 2003-03-18 2006-11-14 Bristol Myers Squibb, Co. Linear chain substituted monocyclic and bicyclic derivatives as factor Xa inhibitors
ATE544765T1 (de) * 2003-12-22 2012-02-15 Leuven K U Res & Dev Imidazoä4,5-cüpyridinverbindungen und verfahren zur antiviralen behandlung
US7381732B2 (en) 2004-10-26 2008-06-03 Bristol-Myers Squibb Company Pyrazolobenzamides and derivatives as factor Xa inhibitors
CA2592388C (en) * 2004-12-21 2013-04-02 Steven S. Bondy Imidazo[4,5-c]pyridine compound and method of antiviral treatment
NZ566799A (en) 2005-09-14 2011-04-29 Takeda Pharmaceutical Dipeptidyl peptidase inhibitors for treating diabetes
CN101360723A (zh) 2005-09-16 2009-02-04 武田药品工业株式会社 制备嘧啶二酮衍生物的方法
TW200734338A (en) * 2006-01-16 2007-09-16 Organon Nv 6-Phenyl-1H-imidazo [4,5-c] pyridine-4-carbonitrile derivatives
WO2007112347A1 (en) 2006-03-28 2007-10-04 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
ES2339298T3 (es) * 2006-07-07 2010-05-18 Gilead Sciences, Inc. Compuesto de piridazina novedoso y uso del mismo.
TW200838536A (en) 2006-11-29 2008-10-01 Takeda Pharmaceutical Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
UA99466C2 (en) 2007-07-06 2012-08-27 Гилиад Сайенсиз, Инк. Crystalline pyridazine compound
CA2772907C (en) 2009-09-11 2018-01-09 Glsynthesis Inc. Selective antibacterials for clostridium difficile infections

Family Cites Families (18)

* Cited by examiner, † Cited by third party
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DE602521C (de) * 1934-09-10 Wilhelm Stoeckicht Dipl Ing Umlaufraederwechselgetriebe, insbesondere fuer Kraftfahrzeuge
DE546449C (de) * 1932-03-12 Mueller Paul Verbindung von Belagblechen
DE574846C (de) * 1933-04-21 Wilhelm Germann Schienenbefestigung unter Verwendung von Schienenfuehrungsleisten
DE595151C (de) * 1934-04-04 Buderus Eisenwerk Verfahren und Vorrichtung zum Regeln des Gewichts von in Schleudergussmaschinen herzustellenden Rohren
DE505893C (de) * 1926-08-07 1930-08-26 Medizinische Produkte Ag F Verfahren zur Herstellung von Eiweiss-Halogen-Schwefelverbindungen
DE564960C (de) * 1931-05-13 1932-11-24 Siemens Schuckertwerke Akt Ges Einrichtung zur Anpassung der Drehzahlregelung, insbesondere von Dampfturbinen, an veraenderte Betriebsverhaeltnisse
DE628556C (de) * 1932-12-07 1936-04-08 Wolf Johannes Mueller Dr Verfahren zur Herstellung von insbesondere hochkonzentrierten Wasserglasloesungen
DE702013C (de) * 1933-07-17 1941-01-29 Union Oil Co Verfahren zur Abscheidung von Paraffin aus paraffinhaltigen OElen
US5798364A (en) * 1992-03-26 1998-08-25 Merck Patent Gesellschaft Mit Beschrankter Haftung Imidazopyridines
DE4110019C2 (de) 1991-03-27 2000-04-13 Merck Patent Gmbh Imidazopyridine, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
DE4140519A1 (de) * 1991-12-09 1993-06-17 Merck Patent Gmbh Benzofurane
DE4211474A1 (de) * 1992-04-06 1993-10-07 Merck Patent Gmbh Imidazopyridine
DE4305602A1 (de) * 1992-06-17 1993-12-23 Merck Patent Gmbh Imidazopyridine
DE4236026A1 (de) * 1992-10-24 1994-04-28 Merck Patent Gmbh Imidazopyridine
DE4242459A1 (de) 1992-12-16 1994-06-23 Merck Patent Gmbh Imidazopyridine
DE4318813A1 (de) 1993-06-07 1994-12-08 Merck Patent Gmbh Imidazopyridine
DE4432860A1 (de) 1994-09-15 1996-03-21 Merck Patent Gmbh Imidazopyridine
EP0960102A1 (de) 1996-07-08 1999-12-01 Du Pont Pharmaceuticals Company Amidinoindole, amidinoazole und analoge davon als inhibitoren von thrombin und von faktor xa

Also Published As

Publication number Publication date
EP1117664A1 (de) 2001-07-25
WO2000020416A1 (de) 2000-04-13
JP2002526542A (ja) 2002-08-20
HUP0104164A3 (en) 2002-08-28
AR020688A1 (es) 2002-05-22
MY130736A (en) 2007-07-31
CA2346033A1 (en) 2000-04-13
US6492384B1 (en) 2002-12-10
CN1324358A (zh) 2001-11-28
HUP0104164A2 (hu) 2002-04-29
ZA200103498B (en) 2002-08-13
PL346542A1 (en) 2002-02-11
BR9914213A (pt) 2001-06-26
NO20011638L (no) 2001-03-30
KR20010074980A (ko) 2001-08-09
AU752574B2 (en) 2002-09-26
ID29466A (id) 2001-08-30
AU5861899A (en) 2000-04-26
NO20011638D0 (no) 2001-03-30
DE19845153A1 (de) 2000-04-06

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