HUP0104164A2 - XA faktor inhibitor hatású imidazo[4,5-c]piridin-4-on származékok, ezeket tartalmazó gyógyászati készítmények és eljárás előállításukra - Google Patents
XA faktor inhibitor hatású imidazo[4,5-c]piridin-4-on származékok, ezeket tartalmazó gyógyászati készítmények és eljárás előállításukraInfo
- Publication number
- HUP0104164A2 HUP0104164A2 HU0104164A HUP0104164A HUP0104164A2 HU P0104164 A2 HUP0104164 A2 HU P0104164A2 HU 0104164 A HU0104164 A HU 0104164A HU P0104164 A HUP0104164 A HU P0104164A HU P0104164 A2 HUP0104164 A2 HU P0104164A2
- Authority
- HU
- Hungary
- Prior art keywords
- compounds
- formula
- factor
- group
- imidazo
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 3
- 108010074860 Factor Xa Proteins 0.000 title 1
- PPNFWYUJXHAZIN-UHFFFAOYSA-N imidazo[4,5-c]pyridin-4-one Chemical class O=C1N=CC=C2N=CN=C12 PPNFWYUJXHAZIN-UHFFFAOYSA-N 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical compound BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 229940123583 Factor Xa inhibitor Drugs 0.000 abstract 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 125000006267 biphenyl group Chemical group 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 230000002107 myocardial effect Effects 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- -1 substituted Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
A tal lm ny Xa faktor inhibitor hat sú (I) ltal nos képletűvegyületekre és sóikra vonatkozik, ahol a képletben R jelentésehidrogénatom, alkilcsoport cikloalkilcsoport; R1 jelentése Ar; R2jelentése Ar'; R3 jelentése H, R, R4, Hal, CN, COOH, COOA vagy CONH2;Ar és Ar' jelentése egym stól függetlenül R4 csoporttal szubsztitu ltfenil-, naftil- vagy bifenilcsoport, R4 jelentése, adott esetbenszubsztitu lt -C(=NH)-NH2 csoport, vagy -NH-C(=NH)-NH2, -C(=O)-N=C(NH2)2, vagy (a) vagy (b) képletű csoport, A jelentésealkilcsoport, Hal jelentése fluor-, klór-, bróm- vagy jódatom, mértéke 1 vagy 2, n értéke 0, 1, 2 vagy 3, p értéke 0 vagy 1. Szintén atal lm ny k"rébe tartozik az (I) ltal nos képletű vegyületek elő llítsi elj r sa, a vegyületek gyógyszerként t"rténő alkalmaz sa, valamintaz ilyen vegyületeket tartalmazó gyógy szati készítmények is, amelyekpl. trombózis, szívizomelhal s, kül"nb"ző gyullad sok és egyébrendellenességek kezelésére alkalmazhatók. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19845153A DE19845153A1 (de) | 1998-10-01 | 1998-10-01 | Imidazo[4,5]-pyridin-4-on-derivate |
PCT/EP1999/006655 WO2000020416A1 (de) | 1998-10-01 | 1999-09-09 | Imidazo[4,5-c-]-pyridin-4-on-derivate mit faktor xa hemmender wirkung |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0104164A2 true HUP0104164A2 (hu) | 2002-04-29 |
HUP0104164A3 HUP0104164A3 (en) | 2002-08-28 |
Family
ID=7883005
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0104164A HUP0104164A3 (en) | 1998-10-01 | 1999-09-09 | Imidazo[4,5-c]-pyridine-4-one derivatives with factor xa inhibiting effect, pharmaceutical compositions containing the same and process for their preparation |
Country Status (18)
Country | Link |
---|---|
US (1) | US6492384B1 (hu) |
EP (1) | EP1117664A1 (hu) |
JP (1) | JP2002526542A (hu) |
KR (1) | KR20010074980A (hu) |
CN (1) | CN1324358A (hu) |
AR (1) | AR020688A1 (hu) |
AU (1) | AU752574B2 (hu) |
BR (1) | BR9914213A (hu) |
CA (1) | CA2346033A1 (hu) |
DE (1) | DE19845153A1 (hu) |
HU (1) | HUP0104164A3 (hu) |
ID (1) | ID29466A (hu) |
MY (1) | MY130736A (hu) |
NO (1) | NO20011638D0 (hu) |
PL (1) | PL346542A1 (hu) |
SK (1) | SK4282001A3 (hu) |
WO (1) | WO2000020416A1 (hu) |
ZA (1) | ZA200103498B (hu) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6858616B2 (en) | 1998-12-23 | 2005-02-22 | Bristol-Myers Squibb Pharma Company | Nitrogen containing heterobicycles as factor Xa inhibitors |
CA2349330C (en) | 1998-12-23 | 2009-09-29 | Dupont Pharmaceuticals Company | Nitrogen containing heterobicycles as factor xa inhibitors |
IL152916A0 (en) * | 2000-06-23 | 2003-06-24 | Bristol Myers Squibb Co | Heteroaryl-phenyl heterobicyclic factor xa inhibitors |
CA2447488A1 (en) | 2001-05-22 | 2002-11-28 | Irina Jacobson | Bicyclic inhibitors of factor xa |
AU2003210958A1 (en) * | 2002-02-08 | 2003-09-02 | Glsynthesis Inc. | Purine and isosteric antibacterial compounds |
GB0215293D0 (en) | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
WO2004050637A2 (en) | 2002-12-03 | 2004-06-17 | Axys Pharmaceuticals, Inc. | 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors |
US7135469B2 (en) * | 2003-03-18 | 2006-11-14 | Bristol Myers Squibb, Co. | Linear chain substituted monocyclic and bicyclic derivatives as factor Xa inhibitors |
EP1706403B9 (en) | 2003-12-22 | 2012-07-25 | K.U.Leuven Research & Development | Imidazo[4,5-c]pyridine compounds and methods of antiviral treatment |
US7381732B2 (en) * | 2004-10-26 | 2008-06-03 | Bristol-Myers Squibb Company | Pyrazolobenzamides and derivatives as factor Xa inhibitors |
AU2005319167B2 (en) * | 2004-12-21 | 2011-09-29 | Gilead Sciences, Inc. | Imidazo[4,5-C]pyridine compound and method of antiviral treatment |
NZ566799A (en) | 2005-09-14 | 2011-04-29 | Takeda Pharmaceutical | Dipeptidyl peptidase inhibitors for treating diabetes |
WO2007035629A2 (en) | 2005-09-16 | 2007-03-29 | Takeda Pharmaceutical Company Limited | Process for the preparation of pyrimidinedione derivatives |
TW200734338A (en) * | 2006-01-16 | 2007-09-16 | Organon Nv | 6-Phenyl-1H-imidazo [4,5-c] pyridine-4-carbonitrile derivatives |
WO2007112347A1 (en) | 2006-03-28 | 2007-10-04 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
PT2038275E (pt) * | 2006-07-07 | 2010-04-08 | Puerstinger Gerhard | Novo composto de piridazina e sua utilização |
TW200838536A (en) | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
UA99466C2 (en) | 2007-07-06 | 2012-08-27 | Гилиад Сайенсиз, Инк. | Crystalline pyridazine compound |
EP2475252B1 (en) | 2009-09-11 | 2016-11-16 | GLSynthesis Inc. | Selective antibacterials for clostridium difficile infections |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE546449C (de) * | 1932-03-12 | Mueller Paul | Verbindung von Belagblechen | |
DE574846C (de) * | 1933-04-21 | Wilhelm Germann | Schienenbefestigung unter Verwendung von Schienenfuehrungsleisten | |
DE602521C (de) * | 1934-09-10 | Wilhelm Stoeckicht Dipl Ing | Umlaufraederwechselgetriebe, insbesondere fuer Kraftfahrzeuge | |
DE595151C (de) * | 1934-04-04 | Buderus Eisenwerk | Verfahren und Vorrichtung zum Regeln des Gewichts von in Schleudergussmaschinen herzustellenden Rohren | |
DE505893C (de) * | 1926-08-07 | 1930-08-26 | Medizinische Produkte Ag F | Verfahren zur Herstellung von Eiweiss-Halogen-Schwefelverbindungen |
DE564960C (de) * | 1931-05-13 | 1932-11-24 | Siemens Schuckertwerke Akt Ges | Einrichtung zur Anpassung der Drehzahlregelung, insbesondere von Dampfturbinen, an veraenderte Betriebsverhaeltnisse |
DE628556C (de) * | 1932-12-07 | 1936-04-08 | Wolf Johannes Mueller Dr | Verfahren zur Herstellung von insbesondere hochkonzentrierten Wasserglasloesungen |
DE702013C (de) * | 1933-07-17 | 1941-01-29 | Union Oil Co | Verfahren zur Abscheidung von Paraffin aus paraffinhaltigen OElen |
US5798364A (en) * | 1992-03-26 | 1998-08-25 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Imidazopyridines |
DE4110019C2 (de) | 1991-03-27 | 2000-04-13 | Merck Patent Gmbh | Imidazopyridine, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen |
DE4140519A1 (de) | 1991-12-09 | 1993-06-17 | Merck Patent Gmbh | Benzofurane |
DE4211474A1 (de) | 1992-04-06 | 1993-10-07 | Merck Patent Gmbh | Imidazopyridine |
DE4305602A1 (de) | 1992-06-17 | 1993-12-23 | Merck Patent Gmbh | Imidazopyridine |
DE4236026A1 (de) | 1992-10-24 | 1994-04-28 | Merck Patent Gmbh | Imidazopyridine |
DE4242459A1 (de) * | 1992-12-16 | 1994-06-23 | Merck Patent Gmbh | Imidazopyridine |
DE4318813A1 (de) * | 1993-06-07 | 1994-12-08 | Merck Patent Gmbh | Imidazopyridine |
DE4432860A1 (de) * | 1994-09-15 | 1996-03-21 | Merck Patent Gmbh | Imidazopyridine |
EP0960102A1 (en) * | 1996-07-08 | 1999-12-01 | Du Pont Pharmaceuticals Company | AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN |
-
1998
- 1998-10-01 DE DE19845153A patent/DE19845153A1/de not_active Withdrawn
-
1999
- 1999-09-09 KR KR1020017002922A patent/KR20010074980A/ko not_active Application Discontinuation
- 1999-09-09 WO PCT/EP1999/006655 patent/WO2000020416A1/de not_active Application Discontinuation
- 1999-09-09 CA CA002346033A patent/CA2346033A1/en not_active Abandoned
- 1999-09-09 US US09/806,418 patent/US6492384B1/en not_active Expired - Fee Related
- 1999-09-09 AU AU58618/99A patent/AU752574B2/en not_active Ceased
- 1999-09-09 CN CN99811601A patent/CN1324358A/zh active Pending
- 1999-09-09 EP EP99946151A patent/EP1117664A1/de not_active Withdrawn
- 1999-09-09 ID IDW20010909A patent/ID29466A/id unknown
- 1999-09-09 JP JP2000574528A patent/JP2002526542A/ja active Pending
- 1999-09-09 BR BR9914213-9A patent/BR9914213A/pt not_active IP Right Cessation
- 1999-09-09 PL PL99346542A patent/PL346542A1/xx unknown
- 1999-09-09 SK SK428-2001A patent/SK4282001A3/sk unknown
- 1999-09-09 HU HU0104164A patent/HUP0104164A3/hu unknown
- 1999-09-28 MY MYPI99004187A patent/MY130736A/en unknown
- 1999-10-01 AR ARP990104991A patent/AR020688A1/es not_active Application Discontinuation
-
2001
- 2001-03-30 NO NO20011638A patent/NO20011638D0/no not_active Application Discontinuation
- 2001-04-30 ZA ZA200103498A patent/ZA200103498B/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU5861899A (en) | 2000-04-26 |
AU752574B2 (en) | 2002-09-26 |
ID29466A (id) | 2001-08-30 |
US6492384B1 (en) | 2002-12-10 |
PL346542A1 (en) | 2002-02-11 |
WO2000020416A1 (de) | 2000-04-13 |
ZA200103498B (en) | 2002-08-13 |
JP2002526542A (ja) | 2002-08-20 |
MY130736A (en) | 2007-07-31 |
AR020688A1 (es) | 2002-05-22 |
CN1324358A (zh) | 2001-11-28 |
NO20011638L (no) | 2001-03-30 |
DE19845153A1 (de) | 2000-04-06 |
EP1117664A1 (de) | 2001-07-25 |
KR20010074980A (ko) | 2001-08-09 |
SK4282001A3 (en) | 2002-10-08 |
CA2346033A1 (en) | 2000-04-13 |
HUP0104164A3 (en) | 2002-08-28 |
NO20011638D0 (no) | 2001-03-30 |
BR9914213A (pt) | 2001-06-26 |
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