SK32693A3 - Cyclopeptides, a method of preparing them and their use as drugs - Google Patents

Cyclopeptides, a method of preparing them and their use as drugs Download PDF

Info

Publication number
SK32693A3
SK32693A3 SK32693A SK32693A SK32693A3 SK 32693 A3 SK32693 A3 SK 32693A3 SK 32693 A SK32693 A SK 32693A SK 32693 A SK32693 A SK 32693A SK 32693 A3 SK32693 A3 SK 32693A3
Authority
SK
Slovakia
Prior art keywords
arg
phe
asp
gly
lys
Prior art date
Application number
SK32693A
Other languages
English (en)
Slovak (sk)
Inventor
Gerd Schnorrenberg
Rainer Palluk
Stefan Heinrichs
Original Assignee
Boehringer Ingelheim Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19904032268 external-priority patent/DE4032268A1/de
Priority claimed from DE19904032269 external-priority patent/DE4032269A1/de
Priority claimed from DE19904032271 external-priority patent/DE4032271A1/de
Priority claimed from DE19914117733 external-priority patent/DE4117733A1/de
Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg
Publication of SK32693A3 publication Critical patent/SK32693A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
    • C07K14/582—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SK32693A 1990-10-11 1991-10-10 Cyclopeptides, a method of preparing them and their use as drugs SK32693A3 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE19904032268 DE4032268A1 (de) 1990-10-11 1990-10-11 Cyclopeptide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE19904032269 DE4032269A1 (de) 1990-10-11 1990-10-11 Cyclopeptide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE19904032271 DE4032271A1 (de) 1990-10-11 1990-10-11 Cyclopeptide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE19914117733 DE4117733A1 (de) 1991-05-30 1991-05-30 Cyclopeptide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
PCT/EP1991/001934 WO1992006998A1 (de) 1990-10-11 1991-10-10 Cyclopeptide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
SK32693A3 true SK32693A3 (en) 1993-09-09

Family

ID=27435038

Family Applications (1)

Application Number Title Priority Date Filing Date
SK32693A SK32693A3 (en) 1990-10-11 1991-10-10 Cyclopeptides, a method of preparing them and their use as drugs

Country Status (12)

Country Link
EP (1) EP0552238A1 (de)
JP (1) JPH06501950A (de)
KR (1) KR930702395A (de)
AU (1) AU8736691A (de)
CA (1) CA2089747A1 (de)
CZ (1) CZ61893A3 (de)
FI (1) FI931499A0 (de)
HU (1) HUT63859A (de)
IE (1) IE913582A1 (de)
PL (1) PL168456B1 (de)
SK (1) SK32693A3 (de)
WO (1) WO1992006998A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6525022B1 (en) 1993-11-12 2003-02-25 Genentech, Inc. Receptor specific atrial natriuretic peptides
US5665704A (en) * 1993-11-12 1997-09-09 Genentech, Inc. Receptor specific atrial natriuretic peptides
US5846932A (en) * 1993-11-12 1998-12-08 Genentech, Inc. Receptor specific atrial natriuretic peptides
AU769791B2 (en) * 1998-06-24 2004-02-05 New York University Novel Staphylococcus peptides for bacterial interference
US6337385B1 (en) 1998-06-24 2002-01-08 The Rockefeller University Staphylococcus peptides for bacterial interference
FR2797689B1 (fr) * 1999-08-16 2003-06-27 Pasteur Sanofi Diagnostics Utilisation de composes synthetiques pour des immunodosages
US6455587B1 (en) * 2000-03-15 2002-09-24 Pharmacor Inc. Amino acid derivatives as HIV aspartyl protease inhibitors
US7388008B2 (en) 2004-08-02 2008-06-17 Ambrilia Biopharma Inc. Lysine based compounds
CA2632095A1 (en) 2005-11-30 2007-06-07 Ambrilia Biopharma Inc. Lysine-based prodrugs of aspartyl protease inhibitors and processes for their preparation
AU2007233116B2 (en) 2006-03-30 2013-05-09 Palatin Technologies, Inc. Cyclic natriuretic peptide constructs
US8580746B2 (en) 2006-03-30 2013-11-12 Palatin Technologies, Inc. Amide linkage cyclic natriuretic peptide constructs
CA2647146A1 (en) 2006-03-30 2007-10-11 Palatin Technologies, Inc. Linear natriuretic peptide constructs
WO2008078200A2 (en) 2006-09-21 2008-07-03 Ambrilia Biopharma Inc. Protease inhibitors
JP5649825B2 (ja) 2007-01-31 2015-01-07 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド 安定化させたｐ５３ペプチドおよびその使用法
KR101525754B1 (ko) 2007-03-28 2015-06-09 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 스티칭된 폴리펩티드
CN108570097A (zh) 2010-08-13 2018-09-25 爱勒让治疗公司 拟肽大环化合物
MX358886B (es) 2011-10-18 2018-08-31 Aileron Therapeutics Inc Macrociclos peptidomimeticos.
US8987414B2 (en) 2012-02-15 2015-03-24 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
SG11201404648PA (en) 2012-02-15 2014-09-26 Aileron Therapeutics Inc Peptidomimetic macrocycles
EP2914256B1 (de) 2012-11-01 2019-07-31 Aileron Therapeutics, Inc. Disubstituierte aminosäuren und verfahren zur herstellung und verwendung davon
US10736932B2 (en) * 2014-05-20 2020-08-11 Ohio State Innovation Foundation Small molecule Ras inhibitors
CN112972378A (zh) 2014-09-24 2021-06-18 艾瑞朗医疗公司 拟肽大环化合物及其制剂
JP2017533889A (ja) 2014-09-24 2017-11-16 エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． ペプチド模倣大環状分子およびその使用
EP3294318A4 (de) 2015-03-20 2019-04-03 Aileron Therapeutics, Inc. Peptidomimetische makrozyklen und verwendungen davon
US10023613B2 (en) 2015-09-10 2018-07-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of MCL-1

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1337891C (en) * 1987-12-16 1996-01-02 John Dimaio Anf derivatives with novel bridging
US4935492A (en) * 1987-12-24 1990-06-19 California Biotechnology Inc. Cyclic analogs of atrial natriuretic peptides
DK380288D0 (da) * 1988-07-07 1988-07-07 Novo Industri As Hidtil ukendet peptider

Also Published As

Publication number Publication date
CA2089747A1 (en) 1992-04-12
IE913582A1 (en) 1992-04-22
FI931499A (fi) 1993-04-02
FI931499A0 (fi) 1993-04-02
HU9301054D0 (en) 1993-07-28
WO1992006998A1 (de) 1992-04-30
AU8736691A (en) 1992-05-20
HUT63859A (en) 1993-10-28
PL168456B1 (pl) 1996-02-29
EP0552238A1 (de) 1993-07-28
CZ61893A3 (en) 1994-01-19
KR930702395A (ko) 1993-09-09
JPH06501950A (ja) 1994-03-03

Similar Documents

Publication Publication Date Title
SK32693A3 (en) Cyclopeptides, a method of preparing them and their use as drugs
FI91075C (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten peptidien valmistamiseksi
US5229489A (en) Parathyroid hormone antagonists
RU2180668C2 (ru) Гептапептидные аналоги окситоцина
JP3765831B2 (ja) 改善された環状ｃｒｆ作用薬
SK15352000A3 (sk) Spôsob výroby cyklických peptidov viazaných k polymérnemu nosiču
US5807986A (en) Methods of making and screening betide libraries
PT88914B (pt) Processo para a preparacao de polipetidos e de composicoes farmaceuticas que os contem
CA1340007C (en) Linear analogs of atrial natruiretic peptides
NZ229393A (en) Peptide derivative with a terminal heterocyclic group
FI92209C (fi) Menetelmä terapeuttisesti käyttökelpoisten peptidiyhdisteiden valmistamiseksi
JPS58116443A (ja) 新規ペプチドおよびその製法
US20040122013A1 (en) Analogs of nocicettin
US4721704A (en) Potent synthetic atrial peptide analogs
Gazal et al. Synthesis of novel protected Nα (ω‐thioalkyl) amino acid building units and their incorporation in backbone cyclic disulfide and thioetheric bridged peptides
FI79716C (fi) Daeggdjur-pgrf.
US5739272A (en) Procedure for obtaining carbocalcitonin
JPH07316195A (ja) 新規なＰＴＨｒＰ関連ペプチド及びその用途
Gazal et al. Novel Gly building units for backbone cyclization: synthesis and incorporation into model peptides
SK62998A3 (en) New lh-rh antagonists with improved effectiveness
JP2010150253A (ja) 肝癌を治療するための薬剤
JPH0232098A (ja) Ｄ―ｃｙｓ↑６バソプレシン拮抗剤
AU700904C (en) Amino acids for making betides and methods of screening and making betide libraries
Saran et al. Conformation and macromolecular interaction of ACE inhibitors enalapril and lisinopril by NMR
JPS63303999A (ja) バソプレシン拮抗剤