SK286191B6 - Použitie solí monoalkylesterov kyseliny fumarovej - Google Patents

Použitie solí monoalkylesterov kyseliny fumarovej Download PDF

Info

Publication number
SK286191B6
SK286191B6 SK539-2001A SK5392001A SK286191B6 SK 286191 B6 SK286191 B6 SK 286191B6 SK 5392001 A SK5392001 A SK 5392001A SK 286191 B6 SK286191 B6 SK 286191B6
Authority
SK
Slovakia
Prior art keywords
fumaric acid
weight
use according
parts
ester
Prior art date
Application number
SK539-2001A
Other languages
English (en)
Slovak (sk)
Other versions
SK5392001A3 (en
Inventor
Rajendra Kumar Joshi
Hans-Peter Strebel
Original Assignee
Fumapharm Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fumapharm Ag filed Critical Fumapharm Ag
Publication of SK5392001A3 publication Critical patent/SK5392001A3/sk
Publication of SK286191B6 publication Critical patent/SK286191B6/sk

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Soft Magnetic Materials (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
SK539-2001A 1998-10-20 1999-10-08 Použitie solí monoalkylesterov kyseliny fumarovej SK286191B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19848260A DE19848260C2 (de) 1998-10-20 1998-10-20 Fumarsäure-Mikrotabletten
PCT/EP1999/007568 WO2000023068A2 (de) 1998-10-20 1999-10-08 Fumarsäure-mikrotabletten

Publications (2)

Publication Number Publication Date
SK5392001A3 SK5392001A3 (en) 2001-08-06
SK286191B6 true SK286191B6 (sk) 2008-05-06

Family

ID=7885018

Family Applications (1)

Application Number Title Priority Date Filing Date
SK539-2001A SK286191B6 (sk) 1998-10-20 1999-10-08 Použitie solí monoalkylesterov kyseliny fumarovej

Country Status (27)

Country Link
US (1) US6355676B1 (ru)
EP (1) EP1123092B1 (ru)
JP (1) JP3550091B2 (ru)
CN (1) CN1235578C (ru)
AT (1) ATE222760T1 (ru)
AU (1) AU745889B2 (ru)
BG (1) BG64836B1 (ru)
BR (1) BR9910267A (ru)
CA (1) CA2329543C (ru)
CZ (1) CZ300005B6 (ru)
DE (2) DE19848260C2 (ru)
DK (1) DK1123092T3 (ru)
EE (1) EE04796B1 (ru)
ES (1) ES2182568T3 (ru)
HK (1) HK1041216B (ru)
HU (1) HU229384B1 (ru)
IL (1) IL140891A (ru)
MX (1) MXPA01003966A (ru)
NO (1) NO328720B1 (ru)
NZ (1) NZ508065A (ru)
PL (1) PL193119B1 (ru)
PT (1) PT1123092E (ru)
RS (1) RS49775B (ru)
RU (1) RU2210366C2 (ru)
SK (1) SK286191B6 (ru)
TR (1) TR200003505T2 (ru)
WO (1) WO2000023068A2 (ru)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19853487A1 (de) 1998-11-19 2000-05-25 Fumapharm Ag Muri Verwendung von Dialkylfumaraten
US20020044962A1 (en) * 2000-06-06 2002-04-18 Cherukuri S. Rao Encapsulation products for controlled or extended release
DE10101307A1 (de) * 2001-01-12 2002-08-01 Fumapharm Ag Muri Fumarsäurederivate als NF-kappaB-Inhibitor
ATE447945T1 (de) * 2001-01-12 2009-11-15 Biogen Idec Internat Gmbh Verwendung von fumarsäureamiden
US6613800B1 (en) * 2001-12-03 2003-09-02 Steven A. Smith Method and compositions for treating psoriasis, eczema, seborrhea and arthritis
DE10217314A1 (de) 2002-04-18 2003-11-13 Fumapharm Ag Muri Carbocyclische und Oxacarboncyclische Fumarsäure-Oligomere
SI1663197T1 (sl) * 2003-09-09 2008-06-30 Biogen Idec Internat Gmbh Uporaba derivatov fumarne kisline za zdravljenje sräśne insuficience in astme
PT2801355E (pt) * 2004-10-08 2015-09-18 Forward Pharma As Composições farmacêuticas de libertação controlada compreendendo um éster de ácido fumárico
US20080004344A1 (en) * 2004-11-10 2008-01-03 Aditech Pharma Ab Novel Salts of Fumaric Acid Monoalkylesters and Their Pharmaceutical Use
ITBO20050123A1 (it) * 2005-03-07 2005-06-06 Alfa Wassermann Spa Formulazioni farmaceutiche gastroresistenti contenenti rifaximina
WO2007006308A1 (en) * 2005-07-07 2007-01-18 Aditech Pharma Ab Novel glucopyranose esters and glucofuranose esters of alkyl- fu marates and their pharmaceutical use
WO2007006307A2 (en) * 2005-07-07 2007-01-18 Aditech Pharma Ab Novel salts of fumaric acid monoalkylesters and their pharmaceutical use
PT1762231E (pt) * 2005-08-19 2010-12-13 Verla Pharm Microcomprimidos de magnésio de libertação retardada
WO2007042034A1 (en) * 2005-10-07 2007-04-19 Aditech Pharma Ab Controlled release pharmaceutical compositions comprising a fumaric acid ester
WO2007042035A2 (en) * 2005-10-07 2007-04-19 Aditech Pharma Ab Combination therapy with fumaric acid esters for the treatment of autoimmune and/or inflammatory disorders
ES2599227T3 (es) * 2007-02-08 2017-01-31 Biogen Ma Inc. Neuroprotección en enfermedades desmielinizantes
ES2916604T1 (es) 2007-02-08 2022-07-04 Biogen Ma Inc Ensayos de detección de nrf2 y métodos y composiciones relacionados
PL2334378T3 (pl) 2008-08-19 2014-09-30 Xenoport Inc Proleki wodorofumaranu metylu, ich kompozycje farmaceutyczne i sposoby zastosowania
EP2564839B1 (en) 2009-01-09 2016-05-11 Forward Pharma A/S Pharmaceutical formulation comprising one or more fumaric acid esters in an erosion matrix
PL2718257T3 (pl) 2011-06-08 2018-04-30 Biogen Ma Inc. Sposób przygotowywania dimetylofumaranu krystalicznego o wysokiej czystości
WO2013076216A1 (en) 2011-11-24 2013-05-30 Synthon Bv Controlled release particles comprising dimethyl fumarate
US20130158077A1 (en) 2011-12-19 2013-06-20 Ares Trading S.A. Pharmaceutical compositions
US9504679B2 (en) 2011-12-19 2016-11-29 Bjoern Colin Kahrs Pharmaceutical compositions comprising glitazones and Nrf2 activators
CN114146079A (zh) 2012-02-07 2022-03-08 比奥根玛公司 含有富马酸二甲酯的药物组合物
MX2014009511A (es) 2012-02-07 2014-10-24 Xenoport Inc Compuestos de fumarato de morfolinoalquilo, composiciones farmaceuticas y metodos de uso.
JP2015526477A (ja) 2012-08-22 2015-09-10 ゼノポート，インコーポレイティド メチル水素フマレートの経口剤形およびそのプロドラッグ
US10945984B2 (en) 2012-08-22 2021-03-16 Arbor Pharmaceuticals, Llc Methods of administering monomethyl fumarate and prodrugs thereof having reduced side effects
US20140171504A1 (en) * 2012-12-14 2014-06-19 Georgia Regents Research Institute, Inc. Methods of Treating Sickle Cell Disease and Related Disorders Using Fumaric Acid Esters
AR094277A1 (es) 2012-12-21 2015-07-22 Biogen Idec Inc Derivados de fumarato sustituidos con deuterio
SG11201507371RA (en) 2013-03-14 2015-10-29 Alkermes Pharma Ireland Ltd Prodrugs of fumarates and their use in treating various deseases
US8669281B1 (en) 2013-03-14 2014-03-11 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
US10179118B2 (en) 2013-03-24 2019-01-15 Arbor Pharmaceuticals, Llc Pharmaceutical compositions of dimethyl fumarate
WO2014197860A1 (en) 2013-06-07 2014-12-11 Xenoport, Inc. Method of making monomethyl fumarate
WO2014205392A1 (en) 2013-06-21 2014-12-24 Xenoport, Inc. Cocrystals of dimethyl fumarate
EA201690102A1 (ru) 2013-08-26 2016-06-30 Форвард Фарма А/С Фармацевтическая композиция, содержащая диметилфумарат, для введения в низкой суточной дозе
US9416096B2 (en) 2013-09-06 2016-08-16 Xenoport, Inc. Crystalline forms of (N,N-Diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate, methods of synthesis and use
WO2015042294A1 (en) 2013-09-18 2015-03-26 Xenoport, Inc. Nanoparticle compositions of dimethyl fumarate
BR112016012179B1 (pt) 2013-12-12 2023-04-18 Almirall, S.A. Composições farmacêuticas que compreendem fumarato de dimetila
CA2940845C (en) 2014-02-24 2019-09-24 Alkermes Pharma Ireland Limited Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases
EP3110408B1 (en) 2014-02-28 2019-01-16 Banner Life Sciences LLC Controlled release enteric soft capsules of fumarate esters
US9326947B1 (en) 2014-02-28 2016-05-03 Banner Life Sciences Llc Controlled release fumarate esters
US9636318B2 (en) 2015-08-31 2017-05-02 Banner Life Sciences Llc Fumarate ester dosage forms
US10098863B2 (en) 2014-02-28 2018-10-16 Banner Life Sciences Llc Fumarate esters
US9999672B2 (en) 2014-03-24 2018-06-19 Xenoport, Inc. Pharmaceutical compositions of fumaric acid esters
WO2016061393A1 (en) 2014-10-15 2016-04-21 Xenoport, Inc. Fumarate compounds, pharmaceutical compositions, and methods of use
CN104490849A (zh) * 2014-11-24 2015-04-08 广东东阳光药业有限公司 一种高密度的富马酸二甲酯肠溶颗粒及其制备方法
US10213411B2 (en) 2015-08-27 2019-02-26 Vijaykumar Rajasekhar Use of prodrugs of fumarates in treating heart failure diseases
WO2017060420A1 (en) 2015-10-07 2017-04-13 Neurovive Pharmaceutical Ab Protected fumaric acid-based metabolites for the treatment of autoimmune diseases
US10463642B2 (en) 2016-02-01 2019-11-05 Vijaykumar Rajasekhar Methods of treating heart failure diseases using prodrugs of methyl hydrogen fumarate
WO2020094767A1 (en) 2018-11-08 2020-05-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of nrf2 activators for the treatment of staphylococcus aureus infections
BR112021018452B1 (pt) 2019-05-31 2022-10-04 Curacle Co., Ltd Comprimido de revestimento entérico e seu método de preparação
CN110898164A (zh) * 2019-12-19 2020-03-24 赣州安宏环保科技有限公司 根除胃肠病幽门螺杆菌感染的富马酸单乙酯钙盐及其用途
US11903918B2 (en) 2020-01-10 2024-02-20 Banner Life Sciences Llc Fumarate ester dosage forms with enhanced gastrointestinal tolerability
KR20220133807A (ko) 2021-03-25 2022-10-05 주식회사 큐라클 특정 약동학적 매개변수를 나타내는 디메틸푸마레이트를 유효성분으로 함유한 약학적 조성물
WO2024047248A1 (en) 2022-09-02 2024-03-07 Institut National de la Santé et de la Recherche Médicale Use of nrf2 activators for the treatment of cerebral small vessel disease

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2530372A1 (de) * 1975-07-08 1977-01-13 Walter Dr Schweckendiek Pharmazeutische zubereitungen zur behandlung von psoriasis
DE2621214C3 (de) * 1976-05-13 1981-11-12 Koronis Gmbh Chemisch-Pharmazeutische Praeparate, 5441 Sassen Verwendung von Stabilisatoren in Arzneimitteln mit Fumarsäuremonoäthylester und desen Mineralsalzen
US5149695A (en) * 1985-01-15 1992-09-22 Speiser Peter P Fumaric acid derivatives, process for the production thereof and pharmaceutical compositions containing same
CH664150A5 (de) 1985-01-15 1988-02-15 Peter Paul Prof Dr Speiser Fumarsaeureprodrug, verfahren zu seiner herstellung und dieses enthaltende darreichungsformen.
US4959389A (en) 1987-10-19 1990-09-25 Speiser Peter P Pharmaceutical preparation for the treatment of psoriatic arthritis
US5424332A (en) * 1987-10-19 1995-06-13 Speiser; Peter P. Pharmaceutical composition and process for the production thereof
DE3834794A1 (de) * 1988-10-12 1990-04-19 F Schielein Oral zu verabreichendes mittel zur behandlung von psoriasis
DE19721099C2 (de) * 1997-05-20 1999-12-02 Fumapharm Ag Muri Verwendung von Fumarsäurederivaten

Also Published As

Publication number Publication date
CA2329543C (en) 2007-02-06
SK5392001A3 (en) 2001-08-06
NO328720B1 (no) 2010-05-03
AU6090699A (en) 2000-05-08
PL193119B1 (pl) 2007-01-31
HK1041216A1 (en) 2002-07-05
ES2182568T3 (es) 2003-03-01
DE19848260C2 (de) 2002-01-17
MXPA01003966A (es) 2002-08-20
HK1041216B (zh) 2006-06-30
ATE222760T1 (de) 2002-09-15
HU229384B1 (en) 2013-11-28
BG64836B1 (bg) 2006-06-30
EE04796B1 (et) 2007-04-16
HUP0103999A2 (hu) 2002-02-28
CN1235578C (zh) 2006-01-11
EE200100030A (et) 2002-06-17
DE19848260A1 (de) 2000-05-18
CA2329543A1 (en) 2000-04-27
NZ508065A (en) 2003-08-29
NO20005239D0 (no) 2000-10-18
DE59902490D1 (de) 2002-10-02
BG104836A (en) 2001-04-30
HUP0103999A3 (en) 2003-11-28
CZ300005B6 (cs) 2009-01-14
JP3550091B2 (ja) 2004-08-04
RU2210366C2 (ru) 2003-08-20
IL140891A (en) 2005-09-25
WO2000023068A2 (de) 2000-04-27
IL140891A0 (en) 2002-02-10
CZ2001871A3 (cs) 2001-07-11
RS49775B (sr) 2008-06-05
BR9910267A (pt) 2001-01-09
TR200003505T2 (tr) 2001-07-23
EP1123092B1 (de) 2002-08-28
YU65500A (sh) 2002-09-19
NO20005239L (no) 2001-05-21
PT1123092E (pt) 2003-01-31
JP2002527475A (ja) 2002-08-27
US6355676B1 (en) 2002-03-12
WO2000023068A3 (de) 2000-07-27
PL344528A1 (en) 2001-11-05
CN1323206A (zh) 2001-11-21
DK1123092T3 (da) 2002-10-14
AU745889B2 (en) 2002-04-11
EP1123092A2 (de) 2001-08-16

Similar Documents

Publication Publication Date Title
SK286191B6 (sk) Použitie solí monoalkylesterov kyseliny fumarovej
PL205948B1 (pl) Zastosowanie jednego lub większej liczby fumaranów dwualkilowych oraz preparat farmaceutyczny
JP2509045B2 (ja) 胆汁酸を含有する経口投与用の胃液耐性のある製剤
KR970005175B1 (ko) 담즙산의 염을 함유하는 경구용 위내성 의약 포뮬레이션
JP3553883B2 (ja) フマル酸誘導体を含有する移植医療における治療剤
CZ299960B6 (cs) Použití derivátu kyseliny fumarové
WO2009110005A2 (en) Modified release pharmaceutical compositions comprising mycophenolate and processes thereof
DE60224194T2 (de) Arzneizusammensetzungen enthaltend terbinafin und deren verwendung
JP2010511023A (ja) メマンチンの製剤組成物
IL88011A (en) Pharmacological preparations for the treatment of psoriasis, psoriatic arthritis, neurodermatitis and regionalitis entitis

Legal Events

Date Code Title Description
TC4A Change of owner's name

Owner name: BIOGEN IDEC INTERNATIONAL GMBH, ZUG, CH

Effective date: 20140623

MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20161008

TC4A Change of owner's name

Owner name: BIOGEN INTERNATIONAL GMBH, ZUG, CH

Effective date: 20170622