SK285730B6 - Deriváty purínu, spôsob ich prípravy, farmaceutická kompozícia, ktorá ich obsahuje, a ich použitie - Google Patents
Deriváty purínu, spôsob ich prípravy, farmaceutická kompozícia, ktorá ich obsahuje, a ich použitie Download PDFInfo
- Publication number
- SK285730B6 SK285730B6 SK126-2002A SK1262002A SK285730B6 SK 285730 B6 SK285730 B6 SK 285730B6 SK 1262002 A SK1262002 A SK 1262002A SK 285730 B6 SK285730 B6 SK 285730B6
- Authority
- SK
- Slovakia
- Prior art keywords
- group
- alkyl
- carbon atoms
- atoms
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/24—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one nitrogen and one sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Otolaryngology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9918035.8A GB9918035D0 (en) | 1999-07-30 | 1999-07-30 | Organic compounds |
PCT/EP2000/007311 WO2001009134A1 (fr) | 1999-07-30 | 2000-07-28 | Inhibiteurs de derives de purine de la tyrosine kinase syk |
Publications (2)
Publication Number | Publication Date |
---|---|
SK1262002A3 SK1262002A3 (en) | 2002-07-02 |
SK285730B6 true SK285730B6 (sk) | 2007-07-06 |
Family
ID=10858317
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK126-2002A SK285730B6 (sk) | 1999-07-30 | 2000-07-28 | Deriváty purínu, spôsob ich prípravy, farmaceutická kompozícia, ktorá ich obsahuje, a ich použitie |
Country Status (33)
Country | Link |
---|---|
US (1) | US6589950B1 (fr) |
EP (1) | EP1200435B1 (fr) |
JP (2) | JP2003506375A (fr) |
KR (1) | KR100485289B1 (fr) |
CN (1) | CN1213047C (fr) |
AR (1) | AR029175A1 (fr) |
AT (1) | ATE251160T1 (fr) |
AU (1) | AU767349B2 (fr) |
BR (1) | BR0012888A (fr) |
CA (1) | CA2379560C (fr) |
CO (1) | CO5180626A1 (fr) |
CZ (1) | CZ2002299A3 (fr) |
DE (1) | DE60005684T2 (fr) |
DK (1) | DK1200435T3 (fr) |
EC (1) | ECSP003589A (fr) |
ES (1) | ES2208395T3 (fr) |
GB (1) | GB9918035D0 (fr) |
HK (1) | HK1046679A1 (fr) |
HU (1) | HUP0201935A3 (fr) |
IL (1) | IL147455A0 (fr) |
MX (1) | MXPA02001102A (fr) |
MY (1) | MY126862A (fr) |
NO (1) | NO20020467L (fr) |
NZ (1) | NZ516667A (fr) |
PE (1) | PE20010543A1 (fr) |
PL (1) | PL354477A1 (fr) |
PT (1) | PT1200435E (fr) |
RU (1) | RU2248977C2 (fr) |
SK (1) | SK285730B6 (fr) |
TR (1) | TR200200234T2 (fr) |
TW (2) | TWI274754B (fr) |
WO (1) | WO2001009134A1 (fr) |
ZA (1) | ZA200200783B (fr) |
Families Citing this family (110)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU1941501A (en) * | 1999-11-30 | 2001-06-12 | Parker Hughes Institute | Syk localized at centrosome |
FR2802091A1 (fr) * | 1999-12-08 | 2001-06-15 | Oreal | Compositions pour la teinture des fibres keratiniques contenant des derives de paraphenylenediamine a groupement azetidinyle |
AU2001293817A1 (en) | 2000-09-20 | 2002-04-02 | Merck Patent Gmbh | 4-amino-quinazolines |
ES2324981T3 (es) | 2000-12-21 | 2009-08-21 | Smithkline Beecham Corporation | Pirimidinaminas como moduladores de la angiogenesis. |
GB0101686D0 (en) * | 2001-01-23 | 2001-03-07 | Cancer Res Campaign Tech | Cyclin dependent kinase inhibitors |
US7829566B2 (en) | 2001-09-17 | 2010-11-09 | Werner Mederski | 4-amino-quinazolines |
AU2002342051B2 (en) * | 2001-10-12 | 2009-06-11 | Irm Llc | Kinase inhibitor scaffolds and methods for their preparation |
US20030158195A1 (en) * | 2001-12-21 | 2003-08-21 | Cywin Charles L. | 1,6 naphthyridines useful as inhibitors of SYK kinase |
WO2003059913A1 (fr) * | 2002-01-10 | 2003-07-24 | Bayer Healthcare Ag | Inhibiteurs de la rho-kinase |
CA2473910C (fr) | 2002-01-23 | 2011-03-15 | Bayer Pharmaceuticals Corporation | Derives de pyrimidine en tant qu'inhibiteurs de la rho-kinase |
JP4469179B2 (ja) | 2002-01-23 | 2010-05-26 | バイエル ファーマセチカル コーポレーション | Rhoキナーゼ阻害剤としてのピリミジン誘導体 |
TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
AU2003212335B8 (en) * | 2002-03-13 | 2009-04-23 | Janssen Pharmaceutica N.V. | Aminocarbonyl-derivatives as novel inhibitors of histone deacetylase |
DK1485354T3 (da) | 2002-03-13 | 2008-09-01 | Janssen Pharmaceutica Nv | Sulfonylamino-derivater som nye inhibitorer af histandeacetylase |
US6897307B2 (en) | 2002-03-28 | 2005-05-24 | Novartis Ag | Process for preparing 2,6-diaminopurine derivatives |
US6855724B2 (en) | 2002-04-08 | 2005-02-15 | Agouron Pharmaceuticals, Inc. | Tropane derivatives useful in therapy |
AU2003276125B2 (en) * | 2002-06-17 | 2007-05-17 | Smithkline Beecham Corporation | Chemical process |
CN101423497A (zh) * | 2002-07-19 | 2009-05-06 | 记忆药物公司 | 作为磷酸二酯酶4抑制剂的6-氨基-1h-吲唑和4-氨基苯并呋喃化合物 |
MXPA05001096A (es) | 2002-07-29 | 2005-11-23 | Rigel Pharmaceuticals Inc | Metodos para tratamiento o prevencion de enfermedades autoinmunes con compuestos de 2,4-diamino-pirimidina. |
EP1444982A1 (fr) * | 2003-02-06 | 2004-08-11 | Merckle Gmbh | Utilisation des dérivés de purine comme inhibiteurs sélectifs de kinases |
KR20120062863A (ko) | 2003-07-30 | 2012-06-14 | 리겔 파마슈티칼스, 인크. | 자가면역 질환의 치료 또는 예방에 사용하기 위한 2,4-피리미딘디아민 화합물 |
CA2535620A1 (fr) * | 2003-08-15 | 2005-02-24 | Irm Llc | Composes et compositions inhibiteurs de l'activite du recepteur tyrosine kinase |
ATE500254T1 (de) * | 2003-09-25 | 2011-03-15 | Janssen Pharmaceutica Nv | Die replikation von hiv hemmende purinderivate |
ZA200603719B (en) * | 2003-11-06 | 2007-09-26 | Celgene Corp | Methods of using and compositions comprising a JNK inhibitor for the treatment and management of asbestos-related diseases and disorders |
EP1682150B1 (fr) * | 2003-11-10 | 2012-12-26 | The Scripps Research Institute | Compositions et procedes pour induire la dedifferenciation cellulaire |
GB0407723D0 (en) * | 2004-04-05 | 2004-05-12 | Novartis Ag | Organic compounds |
US8057815B2 (en) * | 2004-04-19 | 2011-11-15 | Portola Pharmaceuticals, Inc. | Methods of treatment with Syk inhibitors |
WO2005118543A1 (fr) * | 2004-06-03 | 2005-12-15 | Ono Pharmaceutical Co., Ltd. | Inhibiteur des kinases et utilisation de cet inhibiteur |
US7439246B2 (en) | 2004-06-28 | 2008-10-21 | Bristol-Myers Squibb Company | Fused heterocyclic kinase inhibitors |
US7173031B2 (en) * | 2004-06-28 | 2007-02-06 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
US7361764B2 (en) * | 2004-07-27 | 2008-04-22 | Sgx Pharmaceuticals, Inc. | Pyrrolo-pyridine kinase modulators |
US7626021B2 (en) * | 2004-07-27 | 2009-12-01 | Sgx Pharmaceuticals, Inc. | Fused ring heterocycle kinase modulators |
MX2007001127A (es) | 2004-07-27 | 2007-07-11 | Sgx Pharmaceuticals Inc | Moduladores de pirrolo-piridina cinasa. |
US7709645B2 (en) * | 2004-07-27 | 2010-05-04 | Sgx Pharmaceuticals, Inc. | Pyrrolo-pyridine kinase modulators |
MX2007001126A (es) | 2004-07-27 | 2007-09-25 | Sgx Pharmaceuticals Inc | Moduladores de heterociclo cinasa de anillo fusionado. |
WO2006010750A1 (fr) | 2004-07-28 | 2006-02-02 | Janssen Pharmaceutica N.V. | Derives d'indolyl alkyl amine substitues utilises en tant que nouveaux inhibiteurs d'histone deacetylase |
EP1796679A1 (fr) * | 2004-09-10 | 2007-06-20 | Altana Pharma AG | Combinaison de ciclesonide et d'inhibiteur de syk et procedes d'utilisation |
CA2584295C (fr) | 2004-11-24 | 2014-08-26 | Rigel Pharmaceuticals, Inc. | Composes de spiro-2, 4-pyrimidinediamine et leurs utilisations |
CN100526315C (zh) * | 2005-06-16 | 2009-08-12 | 浙江医药股份有限公司新昌制药厂 | N2-喹啉或异喹啉取代的嘌呤衍生物及其制备方法和其用途 |
PE20070593A1 (es) * | 2005-10-13 | 2007-07-23 | Glaxo Group Ltd | Compuestos pirrolopirimidina como inhibidores de syk |
US7803806B2 (en) * | 2005-11-03 | 2010-09-28 | Sgx Pharmaceuticals, Inc. | Pyrimidinyl-thiophene kinase modulators |
WO2007070872A1 (fr) | 2005-12-15 | 2007-06-21 | Rigel Pharmaceuticals, Inc. | Inhibiteurs de kinase et leurs utilisations |
AU2007206942B2 (en) | 2006-01-19 | 2012-08-23 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
SI1981874T1 (sl) * | 2006-01-19 | 2009-10-31 | Janssen Pharmaceutica Nv | Aminofenilni derivati kot novi inhibitorji histon deacetilaze |
JP5137849B2 (ja) * | 2006-01-19 | 2013-02-06 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒストンデアセチラーゼのインヒビターとしての置換インドリル−アルキル−アミノ−誘導体 |
US8008481B2 (en) * | 2006-03-31 | 2011-08-30 | Ericsson Anna M | Indazole compounds |
AU2007309149C1 (en) | 2006-10-23 | 2013-04-04 | Sgx Pharmaceuticals, Inc. | Bicyclic triazoles as protein kinase modulators |
US20080139531A1 (en) * | 2006-12-04 | 2008-06-12 | Alcon Manufacturing Ltd. | Use of connective tissue mast cell stabilizers to facilitate ocular surface re-epithelization and wound repair |
EP2537830A1 (fr) | 2006-12-08 | 2012-12-26 | Irm Llc | Composés et compositions en tant quýinhibiteurs de protéine kinase |
BRPI0720264B1 (pt) * | 2006-12-08 | 2022-03-03 | Novartis Ag | Compostos e composições como inibidores de proteína cinase |
WO2008081928A1 (fr) * | 2006-12-28 | 2008-07-10 | Taisho Pharmaceutical Co., Ltd. | Composé pyrazolopyridimidine |
WO2008107444A1 (fr) | 2007-03-07 | 2008-09-12 | Boehringer Ingelheim International Gmbh | Nouveaux composés |
JP2010524858A (ja) | 2007-04-10 | 2010-07-22 | エスジーエックス ファーマシューティカルズ、インコーポレイテッド | 縮合環複素環キナーゼ調節因子 |
CN101289449A (zh) * | 2007-04-20 | 2008-10-22 | 浙江医药股份有限公司新昌制药厂 | 2,6-二含氮取代的嘌呤衍生物及其制备方法和应用 |
WO2008135232A1 (fr) * | 2007-05-02 | 2008-11-13 | Riccardo Cortese | Utilisation et compositions de dérivés de purine pour le traitement de troubles prolifératifs |
JP2010528991A (ja) * | 2007-05-21 | 2010-08-26 | エスジーエックス ファーマシューティカルズ、インコーポレイテッド | 複素環式キナーゼ調節因子 |
CL2008001540A1 (es) * | 2007-05-29 | 2009-05-22 | Sgx Pharmaceuticals Inc | Compuestos derivados de pirrolopiridinas y pirazolopiridinas; composicion farmaceutica; y uso en el tratamiento del cancer. |
US7705004B2 (en) | 2007-08-17 | 2010-04-27 | Portola Pharmaceuticals, Inc. | Protein kinase inhibitors |
FR2929851B1 (fr) | 2008-04-09 | 2012-11-30 | Centre Nat Rech Scient | Molecules inhibant une voie metabolique impliquant la proteine tyrosine kinase syk et procede d'identification de ces molecules |
US8138339B2 (en) | 2008-04-16 | 2012-03-20 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
PT2323993E (pt) | 2008-04-16 | 2015-10-12 | Portola Pharm Inc | 2,6-diamino-pirimidina-5-il-carboxamidas como inibidores de quinasses syk ou jak |
CN103224497A (zh) * | 2008-04-22 | 2013-07-31 | 波托拉医药品公司 | 蛋白激酶抑制剂 |
US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
HUE035029T2 (en) | 2008-05-21 | 2018-03-28 | Ariad Pharma Inc | Kinase inhibitor phosphorus derivatives |
US20100029689A1 (en) * | 2008-07-02 | 2010-02-04 | Memory Pharmaceuticals Corporation | Phosphodiesterase 4 inhibitors |
WO2010111406A2 (fr) * | 2009-03-24 | 2010-09-30 | Myriad Pharmaceuticals, Inc. | Composés et leurs utilisations thérapeutiques |
SG181803A1 (en) * | 2009-12-17 | 2012-07-30 | Merck Sharp & Dohme | Aminopyrimidines as syk inhibitors |
ES2545616T3 (es) | 2009-12-23 | 2015-09-14 | Takeda Pharmaceutical Company Limited | Pirrolidinonas heteroaromáticas condensadas como inhibidores de SYK |
WO2011153553A2 (fr) | 2010-06-04 | 2011-12-08 | The Regents Of The University Of California | Méthodes et compositions pour l'inhibition de kinases |
EP2489663A1 (fr) | 2011-02-16 | 2012-08-22 | Almirall, S.A. | Composés en tant qu'inhibiteurs de la syk kinase |
EA201391626A1 (ru) | 2011-05-04 | 2014-03-31 | Ариад Фармасьютикалз, Инк. | Соединения для ингибирования клеточной пролиферации в egfr-стимулированных типах рака |
WO2012154518A1 (fr) | 2011-05-10 | 2012-11-15 | Merck Sharp & Dohme Corp. | Bipyridylaminopyridines en tant qu'inhibiteurs de syk |
WO2012154520A1 (fr) | 2011-05-10 | 2012-11-15 | Merck Sharp & Dohme Corp. | Pyridylaminopyridines en tant qu'inhibiteurs de syk |
JP2014513686A (ja) | 2011-05-10 | 2014-06-05 | メルク・シャープ・アンド・ドーム・コーポレーション | Syk阻害薬としてのアミノピリミジン |
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EP2723739B1 (fr) | 2011-06-22 | 2016-08-24 | Takeda Pharmaceutical Company Limited | Dérivés de 6-aza-isoindolin-1-one substitués |
EP2763974B1 (fr) | 2011-10-05 | 2016-09-14 | Merck Sharp & Dohme Corp. | Inhibiteurs de tyrosine kinase de la rate (syk) contenant un phényl carboxamide |
US9216173B2 (en) | 2011-10-05 | 2015-12-22 | Merck Sharp & Dohme Corp. | 2-Pyridyl carboxamide-containing spleen tyrosine kinase (SYK) inhibitors |
US8987456B2 (en) | 2011-10-05 | 2015-03-24 | Merck Sharp & Dohme Corp. | 3-pyridyl carboxamide-containing spleen tyrosine kinase (SYK) inhibitors |
AU2012340555B2 (en) | 2011-11-23 | 2016-10-20 | Portola Pharmaceuticals, Inc. | Pyrazine kinase inhibitors |
AR090650A1 (es) * | 2012-04-12 | 2014-11-26 | Alcon Res Ltd | Tratamiento para respuestas inflamatorias inducidas por microbios en el ojo |
US20150166591A1 (en) | 2012-05-05 | 2015-06-18 | Ariad Pharmaceuticals, Inc. | Methods and compositions for raf kinase mediated diseases |
EP2863914B1 (fr) | 2012-06-20 | 2018-10-03 | Merck Sharp & Dohme Corp. | Dérivés de pyrazolyle en tant qu'inhibiteurs de syk |
EP2863913B1 (fr) | 2012-06-20 | 2018-09-12 | Merck Sharp & Dohme Corp. | Analogues d'imidazolyle en tant qu'inhibiteurs de syk |
WO2013192088A1 (fr) | 2012-06-22 | 2013-12-27 | Merck Sharp & Dohme Corp. | Inhibiteurs de tyrosine kinase splénique (syk) diazines et triazines substituées |
WO2013192098A1 (fr) | 2012-06-22 | 2013-12-27 | Merck Sharp & Dohme Corp. | Inhibiteurs à pyridine substituée de la tyrosine kinase de la rate (syk) |
EP2884982B1 (fr) | 2012-08-20 | 2017-09-20 | Merck Sharp & Dohme Corp. | Inhibiteurs de la phényle tyrosine kinase de la rate (syk) substitués |
US9586931B2 (en) | 2012-09-28 | 2017-03-07 | Merck Sharp & Dohme Corp. | Triazolyl derivatives as Syk inhibitors |
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GB9903762D0 (en) * | 1999-02-18 | 1999-04-14 | Novartis Ag | Organic compounds |
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