CO5180626A1 - Derivados de purina inhibidores de proteina quinasa syk - Google Patents

Derivados de purina inhibidores de proteina quinasa syk

Info

Publication number
CO5180626A1
CO5180626A1 CO00056110A CO00056110A CO5180626A1 CO 5180626 A1 CO5180626 A1 CO 5180626A1 CO 00056110 A CO00056110 A CO 00056110A CO 00056110 A CO00056110 A CO 00056110A CO 5180626 A1 CO5180626 A1 CO 5180626A1
Authority
CO
Colombia
Prior art keywords
alkyl
hydrogen
group
oxygen
sulfur
Prior art date
Application number
CO00056110A
Other languages
English (en)
Inventor
Stephen Paul Collingwood
Judy Hayler
Le Grand Darren Mark
Henri Mattes
Keith Allan Menear
Clive Victor Walker
Xiao-Ling Cockcroft
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CO5180626A1 publication Critical patent/CO5180626A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/24—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one nitrogen and one sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a un compuesto de la fórmula:<EMI FILE="00056110_1" ID="1" IMF=JPEG >en forma libre o de sal, en donde:X es un átomo de oxígeno o de azufre, o un grupo NR5,R1 es un grupo alquilo, alquenilo, cicloalquilo, benzocicloalquilo, cicloalquilalquilo, o aralquilo, que opcionalmente puede estar sustituido por hidroxilo, alcoxilo, carboxilo, o alcoxicarbonilo, o, cuando X es NR5, R1 puede ser de una manera alternativa un grupo heterociclo, o un grupo de la fórmula:<EMI FILE="00056110_2" ID="2" IMF=JPEG >R2, R3, R4, R6, R7, y R8 son cada uno independientemente hidrógeno, halógeno, alquilo, haloalquilo, alcoxilo, carboxilo, alcoxicarbonilo, carboxialquilo, alcoxicarbonilalquilo, -N(R9)R10, SO2N(R11)R12, alquileno de 1 a 4 átomos de carbono-SO2N(R11)R12, ó -CON(R13)R14, o, cuando dos de R2, R3, y R4, o dos de R6, R7, y R8 están unidos a átomos de carbono adyacentes sobre los anillos de benceno indicados, denotan, junto con los átomos de carbono con los que están unidos, un grupo carbocíclico que tiene de 5 a 10 átomos del anillo, o un grupo heterocíclico que tiene de 5 a 10 átomos del anillo, de los cuales uno, dos, ó tres son heteroátomos seleccionados a partir de nitrógeno, oxígeno, y azufre,R5 es hidrógeno o alquilo,R9 es hidrógeno o alquilo, y R10 es hidrógeno, alquilo, o -COR15, en donde R15 es alquilo, haloalquilo, alcoxilo, alcoxialquilo, alcoxicarbonilo, carboxialquilo, o alcoxicarbonilalquilo, o R9 y R10, junto con el átomo de nitrógeno con el que están unidos, denotan un grupo heterocíclico que tiene 5 ó 6 átomos del anillo, de los cuales, uno o dos son heteroátomos seleccionados a partir de nitrógeno, oxígeno, y azufre, R11 es hidrógeno o alquilo, y R12 es hidrógeno, alquilo, hidroxialquilo, alcoxialquilo, carboxialquilo, o alcoxicarbonilalquilo, ó R11 y R12, junto con el átomo de nitrógeno con el que están unidos, denotan un grupo heterocíclico que tiene 5 ó 6 átomos del anillo, de los cuales uno o dos son heteroátomos seleccionados a partir de nitrógeno, oxígeno, y azufre, y R13 y R14 son cada uno independientemente hidrógeno o alquilo;con la excepción de 2-(p-n-butilanilino)-6-metoxipurina, 2-(p-n-butilanilino)-6-tiometilpurina, 2,6-di(fenilamino)purina, 2,6-di(p-tolilamino)purina, y 2-(p-tolilamino)-6-(fenilamino) purina.Igualmente, se refiere a una composición farmacéutica que contiene dicho compuesto, a la aplicación de el mismo y al proceso para su preparación.
CO00056110A 1999-07-30 2000-07-26 Derivados de purina inhibidores de proteina quinasa syk CO5180626A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9918035.8A GB9918035D0 (en) 1999-07-30 1999-07-30 Organic compounds

Publications (1)

Publication Number Publication Date
CO5180626A1 true CO5180626A1 (es) 2002-07-30

Family

ID=10858317

Family Applications (1)

Application Number Title Priority Date Filing Date
CO00056110A CO5180626A1 (es) 1999-07-30 2000-07-26 Derivados de purina inhibidores de proteina quinasa syk

Country Status (33)

Country Link
US (1) US6589950B1 (es)
EP (1) EP1200435B1 (es)
JP (2) JP2003506375A (es)
KR (1) KR100485289B1 (es)
CN (1) CN1213047C (es)
AR (1) AR029175A1 (es)
AT (1) ATE251160T1 (es)
AU (1) AU767349B2 (es)
BR (1) BR0012888A (es)
CA (1) CA2379560C (es)
CO (1) CO5180626A1 (es)
CZ (1) CZ2002299A3 (es)
DE (1) DE60005684T2 (es)
DK (1) DK1200435T3 (es)
EC (1) ECSP003589A (es)
ES (1) ES2208395T3 (es)
GB (1) GB9918035D0 (es)
HK (1) HK1046679A1 (es)
HU (1) HUP0201935A3 (es)
IL (1) IL147455A0 (es)
MX (1) MXPA02001102A (es)
MY (1) MY126862A (es)
NO (1) NO20020467L (es)
NZ (1) NZ516667A (es)
PE (1) PE20010543A1 (es)
PL (1) PL354477A1 (es)
PT (1) PT1200435E (es)
RU (1) RU2248977C2 (es)
SK (1) SK285730B6 (es)
TR (1) TR200200234T2 (es)
TW (2) TWI274754B (es)
WO (1) WO2001009134A1 (es)
ZA (1) ZA200200783B (es)

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