SK285215B6 - Spôsob prípravy sildenafilu a jeho medziprodukty - Google Patents

Spôsob prípravy sildenafilu a jeho medziprodukty Download PDF

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Publication number
SK285215B6
SK285215B6 SK1385-99A SK138599A SK285215B6 SK 285215 B6 SK285215 B6 SK 285215B6 SK 138599 A SK138599 A SK 138599A SK 285215 B6 SK285215 B6 SK 285215B6
Authority
SK
Slovakia
Prior art keywords
tertiary
compound
alkanol
formula
ethanol
Prior art date
Application number
SK1385-99A
Other languages
English (en)
Slovak (sk)
Other versions
SK138599A3 (en
Inventor
Peter James Dunn
Philip Charles Levett
Original Assignee
Pfizer Ireland Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10840421&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SK285215(B6) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Ireland Pharmaceuticals filed Critical Pfizer Ireland Pharmaceuticals
Publication of SK138599A3 publication Critical patent/SK138599A3/sk
Publication of SK285215B6 publication Critical patent/SK285215B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Reproductive Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SK1385-99A 1998-10-12 1999-10-08 Spôsob prípravy sildenafilu a jeho medziprodukty SK285215B6 (sk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9822238.3A GB9822238D0 (en) 1998-10-12 1998-10-12 Process for preparation of pyrazolo[4,3-D]pyrimidin-7-ones and intermediates thereof

Publications (2)

Publication Number Publication Date
SK138599A3 SK138599A3 (en) 2000-05-16
SK285215B6 true SK285215B6 (sk) 2006-09-07

Family

ID=10840421

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1385-99A SK285215B6 (sk) 1998-10-12 1999-10-08 Spôsob prípravy sildenafilu a jeho medziprodukty

Country Status (49)

Country Link
US (3) US6207829B1 (xx)
EP (1) EP0994115B1 (xx)
JP (1) JP3721021B2 (xx)
KR (1) KR100380954B1 (xx)
CN (2) CN1207295C (xx)
AP (1) AP1233A (xx)
AR (1) AR019244A1 (xx)
AT (1) ATE290003T1 (xx)
AU (1) AU756463B2 (xx)
BG (1) BG63205B1 (xx)
BR (1) BR9905092A (xx)
CA (1) CA2285733C (xx)
CO (1) CO5150214A1 (xx)
CR (1) CR6118A (xx)
CU (1) CU22928A3 (xx)
CZ (1) CZ296816B6 (xx)
DE (1) DE69923906T2 (xx)
DK (1) DK0994115T3 (xx)
DZ (1) DZ2912A1 (xx)
EA (1) EA003774B1 (xx)
EE (1) EE04192B1 (xx)
EG (1) EG22630A (xx)
ES (1) ES2237049T3 (xx)
GB (1) GB9822238D0 (xx)
GE (1) GEP20022700B (xx)
GT (1) GT199900172A (xx)
HK (1) HK1027559A1 (xx)
HR (1) HRP990318B1 (xx)
HU (1) HU226162B1 (xx)
ID (1) ID23351A (xx)
IL (11) IL132273A (xx)
IS (1) IS1951B (xx)
MA (1) MA25007A1 (xx)
MY (1) MY124620A (xx)
NO (1) NO313700B1 (xx)
OA (1) OA11165A (xx)
PE (1) PE20001086A1 (xx)
PL (1) PL198150B1 (xx)
PT (1) PT994115E (xx)
RS (1) RS49762B (xx)
SG (1) SG118060A1 (xx)
SI (1) SI0994115T1 (xx)
SK (1) SK285215B6 (xx)
TN (1) TNSN99189A1 (xx)
TR (1) TR199902541A2 (xx)
TW (1) TW589314B (xx)
UA (1) UA66787C2 (xx)
UY (1) UY25750A1 (xx)
ZA (1) ZA996412B (xx)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5204800A (en) * 1999-06-21 2001-01-09 Biochemical Pharmaceutical Factory of Zhuhai Sez, The Process for preparing sildenafil, and troche which comprises sildenafil and apomorphine
WO2001098284A1 (en) * 2000-06-22 2001-12-27 Pfizer Limited Process for the preparation of pyrazolopyrimidinones
US6667398B2 (en) 2000-06-22 2003-12-23 Pfizer Inc Process for the preparation of pyrazolopyrimidinones
EP1176147A1 (en) * 2000-07-28 2002-01-30 Pfizer Limited Process for the preparation of pyrazolo[4,3-d]pyrimidin-7-ones and intermediates thereof
EP1176142A1 (en) * 2000-07-28 2002-01-30 Pfizer Inc. Process for the preparation of pyrazoles
US6407259B1 (en) 2000-07-28 2002-06-18 Pfizer Inc. Process for the preparation of pyrazoles
PE20020394A1 (es) 2000-08-18 2002-06-21 Agouron Pharma Compuestos de pirazol y composiciones farmaceuticas que los contienen, que modulan y/o inhiben la actividad de erab/hadh2
AU2002358772B2 (en) 2001-12-20 2008-11-20 Merck Serono Sa Pyrrolidine derivatives as prostaglandin modulators
US6908923B2 (en) 2001-12-21 2005-06-21 Cytokinetics, Inc. Compositions and methods for treating heart failure
SI1509525T1 (sl) 2002-05-31 2006-12-31 Schering Corp Postopek priprave inhibitorjev ksantinske fosfodiesteraze V in njihovih prekurzorjev
WO2004072079A1 (en) * 2003-02-11 2004-08-26 Pfizer Limited Hydrated and anhydrous sildenafil hemi-citrate compound
EP1605752B1 (en) * 2003-03-27 2011-09-14 Cytokinetics, Inc. Sulfonamides for the treatment of congestive heart failure, their compositions and uses.
CN100360531C (zh) * 2003-12-18 2008-01-09 中国人民解放军军事医学科学院放射与辐射医学研究所 用于预防或治疗阳萎和性冷淡的新吡唑并嘧啶类化合物
US20070010525A1 (en) * 2005-06-27 2007-01-11 Meyer Jackson Method and compositions for modulating neuropeptide hormone secretion
NL2000291C2 (nl) * 2005-11-10 2009-02-17 Pfizer Prod Inc 1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-ylamino)-1H- pyrazool(4,3-d)pyrimidine-5-yl)piperidine-4-carbonzuur en zouten daarvan.
WO2007141805A2 (en) * 2006-06-05 2007-12-13 Matrix Laboratories Limited Novel process for the preparation of sildenafil citrate
CZ308056B6 (cs) * 2015-07-20 2019-11-27 Ustav Experimentalni Botaniky Av Cr V V I 5-Substituované-7-[4-(substituované)benzyl]amino-3-isopropylpyrazolo[4,3-d]pyrimidiny, jejich použití jako antirevmatika, a farmaceutické přípravky
WO2017168174A1 (en) 2016-04-02 2017-10-05 N4 Pharma Uk Limited New pharmaceutical forms of sildenafil
CN107759603B (zh) * 2016-08-18 2020-09-01 四川科伦药物研究院有限公司 一种杂环化合物的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3992441A (en) * 1972-12-26 1976-11-16 Pfizer Inc. Sulfamylbenzoic acids
GB9013750D0 (en) * 1990-06-20 1990-08-08 Pfizer Ltd Therapeutic agents
GB9612514D0 (en) * 1996-06-14 1996-08-14 Pfizer Ltd Novel process
BR9810233A (pt) * 1997-04-25 2000-10-17 Pfizer Pirozolpirimidinonas que inibem fosfodiesterase da guanosina 3`, 5`- monosfofato cìclico do tipo 5 (cgmp pde5) para o tratamento da disfunção sexual.

Also Published As

Publication number Publication date
TNSN99189A1 (fr) 2005-11-10
EG22630A (en) 2003-05-31
IL152927A (en) 2004-06-01
HU9903469D0 (en) 1999-12-28
IS1951B (is) 2004-10-13
IL152923A (en) 2004-02-08
CR6118A (es) 2005-09-16
AP9901672A0 (en) 1999-12-31
SK138599A3 (en) 2000-05-16
AU756463B2 (en) 2003-01-16
TW589314B (en) 2004-06-01
US6207829B1 (en) 2001-03-27
IL132273A0 (en) 2001-03-19
HUP9903469A3 (en) 2000-10-30
PL335959A1 (en) 2000-04-25
US20030069422A1 (en) 2003-04-10
IL152928A0 (en) 2003-06-24
PL198150B1 (pl) 2008-05-30
DE69923906T2 (de) 2006-04-06
EA199900822A3 (ru) 2000-08-28
IL152927A0 (en) 2003-06-24
IL132273A (en) 2004-06-20
KR20000028987A (ko) 2000-05-25
TR199902541A2 (xx) 2000-07-21
IL152923A0 (en) 2003-06-24
EA199900822A2 (ru) 2000-04-24
NO994943L (no) 2000-04-13
ID23351A (id) 2000-04-13
OA11165A (en) 2003-04-22
EP0994115A3 (en) 2000-05-24
UA66787C2 (en) 2004-06-15
RS49762B (sr) 2008-04-04
JP3721021B2 (ja) 2005-11-30
HK1027559A1 (en) 2001-01-19
DZ2912A1 (fr) 2004-03-01
AP1233A (en) 2003-12-18
CA2285733A1 (en) 2000-04-12
NO994943D0 (no) 1999-10-11
EP0994115B1 (en) 2005-03-02
IL152928A (en) 2007-07-04
IS5209A (is) 2000-04-13
EE9900507A (et) 2000-06-15
CN1207295C (zh) 2005-06-22
MA25007A1 (fr) 2000-07-01
ZA996412B (en) 2001-04-11
EE04192B1 (et) 2003-12-15
CZ296816B6 (cs) 2006-06-14
BR9905092A (pt) 2000-08-08
AU5358199A (en) 2000-04-13
GEP20022700B (en) 2002-05-27
CN1255497A (zh) 2000-06-07
CO5150214A1 (es) 2002-04-29
BG103794A (en) 2000-09-29
DK0994115T3 (da) 2005-06-20
SI0994115T1 (xx) 2005-08-31
HU226162B1 (en) 2008-05-28
IL152924A0 (en) 2003-06-24
PT994115E (pt) 2005-06-30
GB9822238D0 (en) 1998-12-09
IL152926A0 (en) 2003-06-24
SG118060A1 (en) 2006-01-27
HRP990318A2 (en) 2000-06-30
ES2237049T3 (es) 2005-07-16
KR100380954B1 (ko) 2003-04-21
UY25750A1 (es) 2001-08-27
EP0994115A2 (en) 2000-04-19
CN1473831A (zh) 2004-02-11
NO313700B1 (no) 2002-11-18
CZ353299A3 (cs) 2000-05-17
ATE290003T1 (de) 2005-03-15
HUP9903469A2 (hu) 2000-08-28
US20010009962A1 (en) 2001-07-26
HRP990318B1 (en) 2004-06-30
CU22928A3 (es) 2004-02-20
IL152926A (en) 2004-02-19
PE20001086A1 (es) 2000-10-18
JP2000119273A (ja) 2000-04-25
BG63205B1 (bg) 2001-06-29
DE69923906D1 (de) 2005-04-07
EA003774B1 (ru) 2003-08-28
IL152924A (en) 2004-02-19
AR019244A1 (es) 2001-12-26
YU48999A (sh) 2002-06-19
CA2285733C (en) 2004-08-24
GT199900172A (es) 2001-03-28
MY124620A (en) 2006-06-30

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Legal Events

Date Code Title Description
MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20111008