SK283425B6 - Deriváty 8-azabicyklo[3,2,1]okt-2-énu, spôsob ich prípravy a použitia - Google Patents

Deriváty 8-azabicyklo[3,2,1]okt-2-énu, spôsob ich prípravy a použitia Download PDF

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Publication number
SK283425B6
SK283425B6 SK287-98A SK28798A SK283425B6 SK 283425 B6 SK283425 B6 SK 283425B6 SK 28798 A SK28798 A SK 28798A SK 283425 B6 SK283425 B6 SK 283425B6
Authority
SK
Slovakia
Prior art keywords
azabicyclo
oct
ene
group
alkyl
Prior art date
Application number
SK287-98A
Other languages
English (en)
Slovak (sk)
Other versions
SK28798A3 (en
Inventor
Peter Moldt
Jorgen Scheel-Kr�Ger
Gunnar M. Olsen
Elsebet Ostergaard Nielsen
Original Assignee
Neurosearch A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch A/S filed Critical Neurosearch A/S
Publication of SK28798A3 publication Critical patent/SK28798A3/sk
Publication of SK283425B6 publication Critical patent/SK283425B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SK287-98A 1995-10-13 1996-10-11 Deriváty 8-azabicyklo[3,2,1]okt-2-énu, spôsob ich prípravy a použitia SK283425B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK115695 1995-10-13
PCT/EP1996/004449 WO1997013770A1 (fr) 1995-10-13 1996-10-11 Derives de 8-azabicyclo(3.2.1)oct-2-ene, leur preparation et leur utilisation

Publications (2)

Publication Number Publication Date
SK28798A3 SK28798A3 (en) 1998-09-09
SK283425B6 true SK283425B6 (sk) 2003-07-01

Family

ID=8101642

Family Applications (1)

Application Number Title Priority Date Filing Date
SK287-98A SK283425B6 (sk) 1995-10-13 1996-10-11 Deriváty 8-azabicyklo[3,2,1]okt-2-énu, spôsob ich prípravy a použitia

Country Status (24)

Country Link
US (1) US6100275A (fr)
EP (1) EP0859777B1 (fr)
JP (1) JP3462505B2 (fr)
KR (1) KR100274829B1 (fr)
CN (1) CN1083840C (fr)
AT (1) ATE362931T1 (fr)
AU (1) AU709327B2 (fr)
BR (1) BR9610960A (fr)
CA (1) CA2233541C (fr)
CZ (1) CZ285093B6 (fr)
DE (1) DE69637097T2 (fr)
DK (1) DK0859777T3 (fr)
EE (1) EE03446B1 (fr)
HU (1) HUP9802433A3 (fr)
IL (1) IL123583A (fr)
IS (1) IS4681A (fr)
NO (1) NO980919L (fr)
NZ (1) NZ320216A (fr)
PL (1) PL185357B1 (fr)
RU (1) RU2157372C2 (fr)
SK (1) SK283425B6 (fr)
TR (1) TR199800628T2 (fr)
UA (1) UA63894C2 (fr)
WO (1) WO1997013770A1 (fr)

Families Citing this family (31)

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GB9510459D0 (en) 1995-05-24 1995-07-19 Zeneca Ltd Bicyclic amines
CA2251851A1 (fr) * 1996-05-13 1997-11-20 Roger Salmon Amines bicycliques utilisees comme insecticides
GB9623944D0 (en) * 1996-11-15 1997-01-08 Zeneca Ltd Bicyclic amine derivatives
GB9624114D0 (en) * 1996-11-20 1997-01-08 Zeneca Ltd Pesticidal bicyclic amine derivatives
TR199901704T2 (xx) 1996-11-26 1999-12-21 Zeneca Limited 8-Azabisiklo$3.2.1]oktan-, 8-azabisiklo$3.2.1]okt-6-en-,9-azabisiklo$3.3.1] nonan-,9-aza-3-oksabisiklo$3.3.1]nonan-ve 9-aza-3-tiabisiklo$3.3.1]nonan t�revleri, bunlar�n haz�rlanmas� ve insektisidler olarak kullan�mlar�.
GB9624611D0 (en) * 1996-11-26 1997-01-15 Zeneca Ltd Bicyclic amine compounds
GB9706222D0 (en) * 1997-03-26 1997-05-14 Zeneca Ltd Bicyclic amine derivatives
HUP0002713A3 (en) 1997-05-30 2001-02-28 Neurosearch As 8-azabicyclo[3,2,1]oct-2-ene and octane derivatives, process for preparation thereof, pharmaceutical compositions comprising thereof and their use
GB9726033D0 (en) 1997-12-09 1998-02-04 Zeneca Ltd Chemical process
TWI221842B (en) * 1997-12-11 2004-10-11 Syngenta Ltd Process for the preparation of 8-azabicyclo(3.2.1)octane derivatives
ZA99681B (en) * 1998-01-28 1999-09-27 Neurosearch As 8-azabicyclo[3.2.1]oct-2-ene derivatives in labelled and unlabelled form and use of 8-azabicyclo[3.2.1]oct-2-ene derivatives in labelled or unlabelled form in diagnostic methods.
US6403605B1 (en) 1998-05-29 2002-06-11 Queen's University At Kingston Methods for the normalization of sexual response and amelioration of long term genital tissue degradation
CA2335336A1 (fr) * 1998-06-19 1999-12-23 James Edmund Audia Inhibition de la reabsorption de la serotonine
DE69914935T2 (de) 1998-11-27 2009-10-01 Neurosearch A/S 8-azabicyclo[3.2.1]okt-2-en- und -oktanderivate
AU2278700A (en) 1999-01-28 2000-08-18 Neurosearch A/S Novel azabicyclo derivatives and their use
AU2315400A (en) * 1999-03-01 2000-09-21 Middleton, Donald Stuart 1,2,3,4-tetrahydro-1-naphthalenamine compounds useful in therapy
ES2393582T3 (es) 1999-09-03 2012-12-26 Apbi Holdings, Llc Procedimiento de utilización de inhibidores de la recaptación de serotonina selectivos de inicio rápido de acción para el tratamiento de las disfunciones sexuales
US6835733B2 (en) 1999-12-20 2004-12-28 Eli Lilly And Company Tropane linked benzofuran derivatives
DE60109924T2 (de) 2000-05-25 2006-02-09 Targacept, Inc. Heteroaryldiazabicycloalkane als liganden für den nikotinischen acetylcholin-rezeptor
US6667314B2 (en) 2000-05-26 2003-12-23 Pfizer, Inc. Tropane derivatives useful in therapy
US6579878B1 (en) 2000-07-07 2003-06-17 Targacept, Inc. Pharmaceutical compositions and methods for use
US6624167B1 (en) 2000-08-04 2003-09-23 Targacept, Inc. Pharmaceutical compositions and methods for use
ES2269467T3 (es) * 2000-10-13 2007-04-01 Neurosearch A/S Tratamiento de transtornos afectivos por la accion combinada de un agonista del receptor nicotinico y una sustancia monoaminergenica.
DE60231386D1 (de) 2001-04-09 2009-04-16 Neurosearch As Adenosin-a2a-rezeptor-antagonisten in kombination mit verbindungen mit neurotrophischer aktivität bei der behandlung von morbus parkinson
TW589312B (en) 2001-05-25 2004-06-01 Wyeth Corp Aryl-8-azabicyclo[3.2.1]octanes for the treatment of depression
AU2003222738B2 (en) 2002-05-07 2009-09-17 Neurosearch A/S Novel azacyclic ethynyl derivatives
US20090137625A1 (en) 2005-04-08 2009-05-28 Dan Peters Novel Enantiomers and Their Use as Monoamine Neurotransmitter Re-Uptake Inhibitors
TW200744590A (en) * 2005-09-01 2007-12-16 Neurosearch As Novel compounds
KR100812499B1 (ko) * 2006-10-16 2008-03-11 이도훈 항경련제
TWI415850B (zh) * 2007-07-20 2013-11-21 Theravance Inc 製備ｍｕ類鴉片受體拮抗劑之中間物的方法
CN101959860A (zh) * 2008-03-05 2011-01-26 神经研究公司 新的4-二苯甲基-四氢-吡啶衍生物及其作为单胺神经递质再摄取抑制剂的用途

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US3133073A (en) * 1959-12-10 1964-05-12 Sterling Drug Inc 3-aryl-1, 5-iminocycloalkanes and preparation thereof
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DK198590D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
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Also Published As

Publication number Publication date
TR199800628T2 (xx) 1998-07-21
PL185357B1 (pl) 2003-04-30
HUP9802433A3 (en) 2000-03-28
KR100274829B1 (ko) 2000-12-15
DE69637097D1 (de) 2007-07-05
CZ285093B6 (cs) 1999-05-12
AU7291796A (en) 1997-04-30
DE69637097T2 (de) 2007-09-20
EE03446B1 (et) 2001-06-15
ATE362931T1 (de) 2007-06-15
NO980919L (no) 1998-06-08
HUP9802433A2 (hu) 1999-04-28
EE9800062A (et) 1998-08-17
UA63894C2 (en) 2004-02-16
SK28798A3 (en) 1998-09-09
CN1083840C (zh) 2002-05-01
IL123583A0 (en) 1998-10-30
CA2233541A1 (fr) 1997-04-17
JPH10512589A (ja) 1998-12-02
KR19990063651A (ko) 1999-07-26
IL123583A (en) 2003-07-31
BR9610960A (pt) 1999-03-02
NO980919D0 (no) 1998-03-03
JP3462505B2 (ja) 2003-11-05
EP0859777B1 (fr) 2007-05-23
EP0859777A1 (fr) 1998-08-26
PL326195A1 (en) 1998-08-31
CA2233541C (fr) 2002-04-30
CN1199400A (zh) 1998-11-18
NZ320216A (en) 1999-05-28
DK0859777T3 (da) 2007-09-03
AU709327B2 (en) 1999-08-26
IS4681A (is) 1998-03-04
RU2157372C2 (ru) 2000-10-10
US6100275A (en) 2000-08-08
WO1997013770A1 (fr) 1997-04-17
CZ75898A3 (cs) 1998-11-11

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