IL123583A - 3-substituted -8-azabicyclo [3,2,1] oct-2-ene derivatives, their preparation and pharmaceutical compositions containing them - Google Patents

3-substituted -8-azabicyclo [3,2,1] oct-2-ene derivatives, their preparation and pharmaceutical compositions containing them

Info

Publication number
IL123583A
IL123583A IL12358396A IL12358396A IL123583A IL 123583 A IL123583 A IL 123583A IL 12358396 A IL12358396 A IL 12358396A IL 12358396 A IL12358396 A IL 12358396A IL 123583 A IL123583 A IL 123583A
Authority
IL
Israel
Prior art keywords
substituted
heteroaryl
alkynyl
cycloalkyl
alkenyl
Prior art date
Application number
IL12358396A
Other languages
English (en)
Other versions
IL123583A0 (en
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Publication of IL123583A0 publication Critical patent/IL123583A0/xx
Publication of IL123583A publication Critical patent/IL123583A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL12358396A 1995-10-13 1996-10-11 3-substituted -8-azabicyclo [3,2,1] oct-2-ene derivatives, their preparation and pharmaceutical compositions containing them IL123583A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK115695 1995-10-13
PCT/EP1996/004449 WO1997013770A1 (fr) 1995-10-13 1996-10-11 Derives de 8-azabicyclo(3.2.1)oct-2-ene, leur preparation et leur utilisation

Publications (2)

Publication Number Publication Date
IL123583A0 IL123583A0 (en) 1998-10-30
IL123583A true IL123583A (en) 2003-07-31

Family

ID=8101642

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12358396A IL123583A (en) 1995-10-13 1996-10-11 3-substituted -8-azabicyclo [3,2,1] oct-2-ene derivatives, their preparation and pharmaceutical compositions containing them

Country Status (24)

Country Link
US (1) US6100275A (fr)
EP (1) EP0859777B1 (fr)
JP (1) JP3462505B2 (fr)
KR (1) KR100274829B1 (fr)
CN (1) CN1083840C (fr)
AT (1) ATE362931T1 (fr)
AU (1) AU709327B2 (fr)
BR (1) BR9610960A (fr)
CA (1) CA2233541C (fr)
CZ (1) CZ285093B6 (fr)
DE (1) DE69637097T2 (fr)
DK (1) DK0859777T3 (fr)
EE (1) EE03446B1 (fr)
HU (1) HUP9802433A3 (fr)
IL (1) IL123583A (fr)
IS (1) IS4681A (fr)
NO (1) NO980919L (fr)
NZ (1) NZ320216A (fr)
PL (1) PL185357B1 (fr)
RU (1) RU2157372C2 (fr)
SK (1) SK283425B6 (fr)
TR (1) TR199800628T2 (fr)
UA (1) UA63894C2 (fr)
WO (1) WO1997013770A1 (fr)

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GB9510459D0 (en) * 1995-05-24 1995-07-19 Zeneca Ltd Bicyclic amines
HUP9902111A3 (en) * 1996-05-13 2000-03-28 Zeneca Ltd Bicyclic amines and their n-oxides, intermediates, preparation and use thereof, insecticide, acaricide and nematocide compositions containing these compounds
GB9623944D0 (en) * 1996-11-15 1997-01-08 Zeneca Ltd Bicyclic amine derivatives
GB9624114D0 (en) * 1996-11-20 1997-01-08 Zeneca Ltd Pesticidal bicyclic amine derivatives
ES2216131T3 (es) 1996-11-26 2004-10-16 Syngenta Limited Derivados de 8-azabiciclo 3,2,1 )octano-,8- azabiciclo 3,2.1) oct-6- eno- 9-azabiciclo 3.3.1) nonano-, 9-aza -3- oxabiciclo 3.3.1) nonano - y 9 -aza-3- tiabiciclo 3.3.1) nonano, su preparacion y su uso como insecticidas.
GB9624611D0 (en) * 1996-11-26 1997-01-15 Zeneca Ltd Bicyclic amine compounds
GB9706222D0 (en) * 1997-03-26 1997-05-14 Zeneca Ltd Bicyclic amine derivatives
DK0984965T3 (da) 1997-05-30 2004-09-27 Neurosearch As 8-azabicyclo[3.2.1]oct-2-enderivater som cholinerge ligander ved nikotin-ACh-receptorer
GB9726033D0 (en) 1997-12-09 1998-02-04 Zeneca Ltd Chemical process
TWI221842B (en) 1997-12-11 2004-10-11 Syngenta Ltd Process for the preparation of 8-azabicyclo(3.2.1)octane derivatives
WO1999038866A1 (fr) * 1998-01-28 1999-08-05 Neurosearch A/S Derives de 8-azabicyclo[3.2.1]oct-2-ene sous forme marquee et utilisation de derives de 8-azabicyclo[3.2.1]oct-2-ene sous forme marquee ou non marquee
US6403605B1 (en) 1998-05-29 2002-06-11 Queen's University At Kingston Methods for the normalization of sexual response and amelioration of long term genital tissue degradation
CA2335336A1 (fr) * 1998-06-19 1999-12-23 James Edmund Audia Inhibition de la reabsorption de la serotonine
EP1133494B1 (fr) 1998-11-27 2004-02-18 Neurosearch A/S Derives de 8-azabicyclo 3.2.1]oct-2-ene et de 8-azabicyclo 3.2.1]octane
ATE258176T1 (de) 1999-01-28 2004-02-15 Neurosearch As Neue azabicyclo derivate und ihre verwendung
ES2245639T3 (es) * 1999-03-01 2006-01-16 Pfizer Inc. Compuestos 1,2,3,4-tetrahidro-1-naftalenamina utiles en terapia.
EE05315B1 (et) 1999-09-03 2010-08-16 Eli Lilly And Company Dapoksetiini v?i selle farmatseutiliselt vastuv?etava soola kasutamine ravimi valmistamiseks, mis on ette n„htud imetajal esineva seksuaalse funktsioonih„ire ravimiseks v?i m?jutamiseks
WO2001046186A1 (fr) * 1999-12-20 2001-06-28 Eli Lilly And Company Derives de benzofuranne
JP2003534344A (ja) 2000-05-25 2003-11-18 ターガセプト，インコーポレイテッド ニコチン性コリン受容体リガンドとしてのヘテロアリールジアザビシクロアルカン
US6667314B2 (en) 2000-05-26 2003-12-23 Pfizer, Inc. Tropane derivatives useful in therapy
US6579878B1 (en) 2000-07-07 2003-06-17 Targacept, Inc. Pharmaceutical compositions and methods for use
US6624167B1 (en) 2000-08-04 2003-09-23 Targacept, Inc. Pharmaceutical compositions and methods for use
US7307087B2 (en) * 2000-10-13 2007-12-11 Neurosearch A/S Treatment of affective disorders by the combined action of a nicotinic receptor agonist and a monoaminergic substance
DE60231386D1 (de) 2001-04-09 2009-04-16 Neurosearch As Adenosin-a2a-rezeptor-antagonisten in kombination mit verbindungen mit neurotrophischer aktivität bei der behandlung von morbus parkinson
AR035898A1 (es) 2001-05-25 2004-07-21 Wyeth Corp Aril-8-azabiciclo[3.2.1]octanos, un proceso para su preparacion, una formulacion y el uso de dichos compuestos para la manufactura de un medicamento para el tratamiento de la depresion
WO2003094830A2 (fr) * 2002-05-07 2003-11-20 Neurosearch A/S Nouveaux derives d'ethynyl azacycliques
EP2272847A1 (fr) 2005-04-08 2011-01-12 NeuroSearch A/S Enantiomères et leur utilisation comme inhibiteurs du recaptage des neurotransmetteurs monoamine
TW200744590A (en) * 2005-09-01 2007-12-16 Neurosearch As Novel compounds
KR100812499B1 (ko) * 2006-10-16 2008-03-11 이도훈 항경련제
TWI415850B (zh) * 2007-07-20 2013-11-21 Theravance Inc 製備ｍｕ類鴉片受體拮抗劑之中間物的方法
JP2011513354A (ja) * 2008-03-05 2011-04-28 ノイロサーチ アクティーゼルスカブ 新規な４−ベンズヒドリル−テトラヒドロ−ピリジン誘導体及びモノアミン神経伝達物質再取り込み阻害薬としてのその使用

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GB247886A (en) * 1925-11-02 1926-02-25 Thomas Stewart Hamilton Improvements in attachments for leaf springs
US3133073A (en) * 1959-12-10 1964-05-12 Sterling Drug Inc 3-aryl-1, 5-iminocycloalkanes and preparation thereof
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DK198590D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
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NZ241481A (en) * 1991-02-04 1994-06-27 Hoechst Roussel Pharma Derivatives of 8-aza-bicyclo[3.2.1]octane and pharmaceutical compositions thereof
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Also Published As

Publication number Publication date
IS4681A (is) 1998-03-04
EE9800062A (et) 1998-08-17
CN1083840C (zh) 2002-05-01
CZ75898A3 (cs) 1998-11-11
US6100275A (en) 2000-08-08
HUP9802433A3 (en) 2000-03-28
KR100274829B1 (ko) 2000-12-15
PL326195A1 (en) 1998-08-31
AU7291796A (en) 1997-04-30
NO980919L (no) 1998-06-08
WO1997013770A1 (fr) 1997-04-17
DE69637097D1 (de) 2007-07-05
HUP9802433A2 (hu) 1999-04-28
EP0859777B1 (fr) 2007-05-23
DK0859777T3 (da) 2007-09-03
NZ320216A (en) 1999-05-28
NO980919D0 (no) 1998-03-03
CA2233541A1 (fr) 1997-04-17
JP3462505B2 (ja) 2003-11-05
SK28798A3 (en) 1998-09-09
CN1199400A (zh) 1998-11-18
CA2233541C (fr) 2002-04-30
BR9610960A (pt) 1999-03-02
RU2157372C2 (ru) 2000-10-10
PL185357B1 (pl) 2003-04-30
CZ285093B6 (cs) 1999-05-12
DE69637097T2 (de) 2007-09-20
EP0859777A1 (fr) 1998-08-26
IL123583A0 (en) 1998-10-30
EE03446B1 (et) 2001-06-15
JPH10512589A (ja) 1998-12-02
UA63894C2 (en) 2004-02-16
KR19990063651A (ko) 1999-07-26
AU709327B2 (en) 1999-08-26
ATE362931T1 (de) 2007-06-15
SK283425B6 (sk) 2003-07-01
TR199800628T2 (xx) 1998-07-21

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Legal Events

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FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees