SK282865B6 - Spôsob prípravy kyseliny (S)-3-(aminometyl)-5-metylhexánovej a medziprodukty - Google Patents

Spôsob prípravy kyseliny (S)-3-(aminometyl)-5-metylhexánovej a medziprodukty Download PDF

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Publication number
SK282865B6
SK282865B6 SK1645-97A SK164597A SK282865B6 SK 282865 B6 SK282865 B6 SK 282865B6 SK 164597 A SK164597 A SK 164597A SK 282865 B6 SK282865 B6 SK 282865B6
Authority
SK
Slovakia
Prior art keywords
acid
aminomethyl
water
methylhexanoic acid
methylhexanoic
Prior art date
Application number
SK1645-97A
Other languages
English (en)
Slovak (sk)
Other versions
SK164597A3 (en
Inventor
Todd Michel Grote
Brian Keith Huckabee
Thomas Mulhern
Denis Martin Sobieray
Robert Daniel Titus
Original Assignee
Warner-Lambert Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner-Lambert Company filed Critical Warner-Lambert Company
Publication of SK164597A3 publication Critical patent/SK164597A3/sk
Publication of SK282865B6 publication Critical patent/SK282865B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/34—Preparation of optical isomers by separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/10—Formation of amino groups in compounds containing carboxyl groups with simultaneously increasing the number of carbon atoms in the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C07C255/22—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton containing cyano groups and at least two carboxyl groups bound to the carbon skeleton

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Seasonings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SK1645-97A 1995-06-07 1996-05-13 Spôsob prípravy kyseliny (S)-3-(aminometyl)-5-metylhexánovej a medziprodukty SK282865B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/474,874 US5637767A (en) 1995-06-07 1995-06-07 Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid
PCT/US1996/006819 WO1996040617A1 (en) 1995-06-07 1996-05-13 Method of making (s)-3-(aminomethyl)-5-methylhexanoic acid

Publications (2)

Publication Number Publication Date
SK164597A3 SK164597A3 (en) 1998-05-06
SK282865B6 true SK282865B6 (sk) 2003-01-09

Family

ID=23885291

Family Applications (2)

Application Number Title Priority Date Filing Date
SK606-2002A SK283507B6 (sk) 1995-06-07 1996-05-13 Spôsob prípravy kyseliny (±)-3-(aminometyl)-5-metylhexánovej
SK1645-97A SK282865B6 (sk) 1995-06-07 1996-05-13 Spôsob prípravy kyseliny (S)-3-(aminometyl)-5-metylhexánovej a medziprodukty

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SK606-2002A SK283507B6 (sk) 1995-06-07 1996-05-13 Spôsob prípravy kyseliny (±)-3-(aminometyl)-5-metylhexánovej

Country Status (18)

Country Link
US (4) US5637767A (cs)
EP (1) EP0830338B1 (cs)
JP (1) JP3874306B2 (cs)
AT (1) ATE210628T1 (cs)
CA (1) CA2219150C (cs)
CZ (2) CZ291147B6 (cs)
DE (1) DE69617948T2 (cs)
DK (1) DK0830338T3 (cs)
EE (1) EE04053B1 (cs)
ES (1) ES2170231T3 (cs)
GE (1) GEP19991870B (cs)
HU (2) HU229957B1 (cs)
NZ (2) NZ501628A (cs)
PL (3) PL185425B1 (cs)
PT (1) PT830338E (cs)
SI (1) SI0830338T1 (cs)
SK (2) SK283507B6 (cs)
WO (1) WO1996040617A1 (cs)

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US7169812B2 (en) * 2003-07-01 2007-01-30 Medtronic, Inc. Process for producing injectable gabapentin compositions
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US7488846B2 (en) * 2005-04-11 2009-02-10 Teva Pharmaceuical Industries Ltd. Pregabalin free of lactam and a process for preparation thereof
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EP1912931A2 (en) * 2006-05-31 2008-04-23 Teva Pharmaceutical Industries Ltd. Preparation of (s)-pregabalin-nitrile
AU2007274034B2 (en) * 2006-07-12 2012-11-15 Generics [Uk] Limited Process of preparing a gamma-amino acid
WO2008062460A2 (en) * 2006-10-06 2008-05-29 Cadila Healthcare Limited Crystalline forms of pregabalin
EP2021318A2 (en) * 2007-03-22 2009-02-11 Teva Pharmaceutical Industries Ltd. Synthesis of (s)-(+)-3-(aminomethyl)-5-methyl hexanoic acid
WO2008138874A1 (en) * 2007-05-09 2008-11-20 Chemo Ibérica, S.A. Process for preparing (s)-pregabalin by optical resolution of racemic pregabalin
EP1992609A1 (en) * 2007-05-14 2008-11-19 Dipharma Francis S.r.l. A process for the preparation of a (S)(+)-3-(aminomethyl)-5-methylhexanoic acid
EP2170813A4 (en) * 2007-06-25 2012-05-16 Reddy Manne Satyanarayana NEW METHOD OF PREPARING PREGABALIN
WO2009044409A2 (en) * 2007-10-01 2009-04-09 Natco Pharma Limited Novel resolution process for pregabalin
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CN101965328A (zh) * 2007-12-26 2011-02-02 基因里克斯(英国)有限公司 普瑞巴林的制备方法
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CN102112436A (zh) * 2008-06-03 2011-06-29 基因里克斯(英国)有限公司 用于合成氨基酸的新的和有效方法
US20100087525A1 (en) * 2008-06-23 2010-04-08 Lilach Hedvati Stereoselective enzymatic synthesis of (s) or (r)-iso-butyl-glutaric ester
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IT1394292B1 (it) 2009-05-07 2012-06-06 Dipharma Francis Srl Procedimento per la sintesi di pregabalina
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CN103980144B (zh) * 2014-05-16 2018-08-17 浙江华海药业股份有限公司 一种普瑞巴林中间体母液的套用方法
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CN104086439B (zh) * 2014-06-30 2018-11-16 浙江华海药业股份有限公司 一种pregabalin中间体拆分剂(R)-(+)-α-苯乙胺的回收方法
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CN104649919B (zh) * 2015-02-10 2021-02-12 浙江华海药业股份有限公司 一种小颗粒普瑞巴林的制备方法
JP2018520112A (ja) 2015-05-26 2018-07-26 オディディ，イサ 制御持続放出プレガバリン
CN105175276A (zh) * 2015-07-25 2015-12-23 安徽东凯生物科技有限公司 一种光学纯(r)-3-氨甲酰甲基-5-甲基己酸的合成方法
CN105061234A (zh) * 2015-08-18 2015-11-18 太仓运通生物化工有限公司 一种制备普瑞巴林的方法
CN105085290A (zh) * 2015-08-18 2015-11-25 太仓运通生物化工有限公司 一种合成普瑞巴林的方法
CN105348125A (zh) * 2015-11-26 2016-02-24 太仓运通生物化工有限公司 一种以异戊醛为原料合成普瑞巴林的方法
CN111333529A (zh) * 2018-12-19 2020-06-26 北京万全德众医药生物技术有限公司 普瑞巴林的一种制备方法
CN109942446B (zh) * 2019-04-17 2021-09-07 黄冈鲁班药业股份有限公司 一种普瑞巴林的制备方法
EP4230199A4 (en) 2020-12-04 2024-07-31 Laboratorios Silanes S A De C V COATED AND STABLE SOLID PHARMACEUTICAL COMPOSITION OF AN ANALGESIC AND AN ANTIEPILEPTIC AGAINST PAIN
CN112939809A (zh) * 2020-12-30 2021-06-11 江苏恒沛药物科技有限公司 一种1-氰基-3-甲基丁基丙二酸二乙酯的制备方法
CN116041214A (zh) * 2022-11-15 2023-05-02 奥锐特药业股份有限公司 一种普瑞巴林中间体的制备方法及其应用

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Also Published As

Publication number Publication date
GEP19991870B (en) 1999-12-06
EP0830338B1 (en) 2001-12-12
HUP9802504A2 (hu) 1999-02-01
HU0500934D0 (en) 2005-12-28
SK164597A3 (en) 1998-05-06
JP3874306B2 (ja) 2007-01-31
NZ308319A (en) 2000-02-28
PL323795A1 (en) 1998-04-27
SK283507B6 (sk) 2003-08-05
EE9700320A (et) 1998-06-15
NZ501628A (en) 2001-09-28
US5637767A (en) 1997-06-10
ATE210628T1 (de) 2001-12-15
AU5792196A (en) 1996-12-30
EP0830338A1 (en) 1998-03-25
PL185425B1 (pl) 2003-05-30
EE04053B1 (et) 2003-06-16
WO1996040617A1 (en) 1996-12-19
CZ384697A3 (cs) 1998-03-18
PL185560B1 (pl) 2003-06-30
CA2219150C (en) 2008-11-18
CZ296895B6 (cs) 2006-07-12
US20010016665A1 (en) 2001-08-23
SI0830338T1 (en) 2002-04-30
CZ291147B6 (cs) 2002-12-11
HU228194B1 (en) 2013-01-28
PL185557B1 (pl) 2003-06-30
US6046353A (en) 2000-04-04
US5840956A (en) 1998-11-24
JPH11506726A (ja) 1999-06-15
AU700091B2 (en) 1998-12-24
ES2170231T3 (es) 2002-08-01
HUP9802504A3 (en) 2000-06-28
HU229957B1 (hu) 2015-03-30
DK0830338T3 (da) 2002-04-02
DE69617948D1 (de) 2002-01-24
PT830338E (pt) 2002-04-29
DE69617948T2 (de) 2002-06-13
MX9708652A (es) 1998-06-30
CA2219150A1 (en) 1996-12-19

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