SI0830338T1 - Method of making 3-(aminomethyl)-5-methylhexanoic acid - Google Patents

Method of making 3-(aminomethyl)-5-methylhexanoic acid

Info

Publication number
SI0830338T1
SI0830338T1 SI9630390T SI9630390T SI0830338T1 SI 0830338 T1 SI0830338 T1 SI 0830338T1 SI 9630390 T SI9630390 T SI 9630390T SI 9630390 T SI9630390 T SI 9630390T SI 0830338 T1 SI0830338 T1 SI 0830338T1
Authority
SI
Slovenia
Prior art keywords
aminomethyl
methylhexanoic acid
alkali
earth metal
alkaline earth
Prior art date
Application number
SI9630390T
Other languages
English (en)
Slovenian (sl)
Inventor
Todd Michel Grote
Brian Keith Huckabee
Thomas Mulhern
Denis Martin Sobieray
Robert Daniel Titus
Original Assignee
Warner-Lambert Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner-Lambert Company filed Critical Warner-Lambert Company
Publication of SI0830338T1 publication Critical patent/SI0830338T1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30Preparation of optical isomers
    • C07C227/34Preparation of optical isomers by separation of optical isomers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04Formation of amino groups in compounds containing carboxyl groups
    • C07C227/10Formation of amino groups in compounds containing carboxyl groups with simultaneously increasing the number of carbon atoms in the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • C07C255/01Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • C07C255/01Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C07C255/22Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton containing cyano groups and at least two carboxyl groups bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Seasonings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SI9630390T 1995-06-07 1996-05-13 Method of making 3-(aminomethyl)-5-methylhexanoic acid SI0830338T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/474,874 US5637767A (en) 1995-06-07 1995-06-07 Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid
EP96914618A EP0830338B1 (en) 1995-06-07 1996-05-13 Method of making 3-(aminomethyl)-5-methylhexanoic acid
PCT/US1996/006819 WO1996040617A1 (en) 1995-06-07 1996-05-13 Method of making (s)-3-(aminomethyl)-5-methylhexanoic acid

Publications (1)

Publication Number Publication Date
SI0830338T1 true SI0830338T1 (en) 2002-04-30

Family

ID=23885291

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9630390T SI0830338T1 (en) 1995-06-07 1996-05-13 Method of making 3-(aminomethyl)-5-methylhexanoic acid

Country Status (18)

Country Link
US (4) US5637767A (cs)
EP (1) EP0830338B1 (cs)
JP (1) JP3874306B2 (cs)
AT (1) ATE210628T1 (cs)
CA (1) CA2219150C (cs)
CZ (2) CZ291147B6 (cs)
DE (1) DE69617948T2 (cs)
DK (1) DK0830338T3 (cs)
EE (1) EE04053B1 (cs)
ES (1) ES2170231T3 (cs)
GE (1) GEP19991870B (cs)
HU (2) HU229957B1 (cs)
NZ (2) NZ501628A (cs)
PL (3) PL185560B1 (cs)
PT (1) PT830338E (cs)
SI (1) SI0830338T1 (cs)
SK (2) SK282865B6 (cs)
WO (1) WO1996040617A1 (cs)

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US20080026433A1 (en) * 2006-05-31 2008-01-31 Lilach Hedvati Use of enzymatic resolution for the preparation of intermediates of pregabalin
US20090286880A1 (en) * 2006-07-12 2009-11-19 Generics [Uk] Limited Novel process
WO2008062460A2 (en) * 2006-10-06 2008-05-29 Cadila Healthcare Limited Crystalline forms of pregabalin
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WO2009001372A2 (en) 2007-06-25 2008-12-31 Manne Satyanarayana Reddy A novel process for the preparation of pregabalin
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WO2009046309A2 (en) * 2007-10-03 2009-04-09 Teva Pharmaceutical Industries Ltd. Pregabalin -4-eliminate, pregabalin 5-eliminate, their use as reference marker and standard, and method to produce pregabalin containing low levels thereof
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WO2009087674A2 (en) * 2007-12-18 2009-07-16 Watson Pharma Private Limited Improved process for the preparation of (s)-pregabalin
JP2011507941A (ja) * 2007-12-26 2011-03-10 ジェネリクス・(ユーケー)・リミテッド プレガバリンの製造方法
EP2236496A4 (en) * 2007-12-27 2011-12-14 Toray Finechemicals Co Ltd OPTICALLY ACTIVE 3-AMINOPYRROLIDIN SALT, METHOD FOR THE PREPARATION THEREOF AND METHOD FOR THE RACEMATING OF 3-AMINO-PYROLIDIN
US8592625B2 (en) * 2008-01-02 2013-11-26 Zheinjiang Jiuzhou Pharmaceutical Co., Ltd. Process for resolving S-3-(aminomethyl)-5-methylhexanoic acid
US20110144383A1 (en) * 2008-02-18 2011-06-16 Matrix Laboratories Limited Process for preparing (s)-3-(aminomethyl)-5-methylhexanoic acid
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CN101585778B (zh) * 2008-05-19 2014-08-13 上海臣邦医药科技有限公司 一种普瑞巴林制备方法
EA019285B1 (ru) * 2008-05-21 2014-02-28 Сандоз Аг Способ стереоселективного ферментативного гидролиза эфира 5-метил-3-нитрометилгексановой кислоты
WO2009147434A1 (en) * 2008-06-03 2009-12-10 Generics [Uk] Limited A novel and efficient method for the synthesis of an amino acid
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WO2010061403A2 (en) * 2008-11-26 2010-06-03 Ind-Swift Laboratories Limited Process to prepare highly pure (s)-pregabalin
WO2010070593A2 (en) 2008-12-19 2010-06-24 Pfizer Ireland Pharmaceuticals Malonate esters
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HUP1000186A2 (en) * 2010-04-08 2011-10-28 Richter Gedeon Nyrt Novel industrial process of preparing (s)-(+) pregabalin
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CN103980144B (zh) * 2014-05-16 2018-08-17 浙江华海药业股份有限公司 一种普瑞巴林中间体母液的套用方法
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CN104086439B (zh) * 2014-06-30 2018-11-16 浙江华海药业股份有限公司 一种pregabalin中间体拆分剂(R)-(+)-α-苯乙胺的回收方法
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CN104649919B (zh) * 2015-02-10 2021-02-12 浙江华海药业股份有限公司 一种小颗粒普瑞巴林的制备方法
HK1253735A1 (zh) 2015-05-26 2019-06-28 艾萨‧欧蒂迪 控制延缓释放普瑞巴林
CN105175276A (zh) * 2015-07-25 2015-12-23 安徽东凯生物科技有限公司 一种光学纯(r)-3-氨甲酰甲基-5-甲基己酸的合成方法
CN105085290A (zh) * 2015-08-18 2015-11-25 太仓运通生物化工有限公司 一种合成普瑞巴林的方法
CN105061234A (zh) * 2015-08-18 2015-11-18 太仓运通生物化工有限公司 一种制备普瑞巴林的方法
CN105348125A (zh) * 2015-11-26 2016-02-24 太仓运通生物化工有限公司 一种以异戊醛为原料合成普瑞巴林的方法
CN111333529A (zh) * 2018-12-19 2020-06-26 北京万全德众医药生物技术有限公司 普瑞巴林的一种制备方法
CN109942446B (zh) * 2019-04-17 2021-09-07 黄冈鲁班药业股份有限公司 一种普瑞巴林的制备方法
MX2022015331A (es) 2020-12-04 2023-02-01 Laboratorios Silanes S A De C V Composicion farmaceutica solida recubierta y estable de un analgesico opioide y un antiepileptico para el dolor.
CN112939809A (zh) * 2020-12-30 2021-06-11 江苏恒沛药物科技有限公司 一种1-氰基-3-甲基丁基丙二酸二乙酯的制备方法
CN116041214B (zh) * 2022-11-15 2025-04-22 奥锐特药业股份有限公司 一种普瑞巴林中间体的制备方法及其应用

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Also Published As

Publication number Publication date
US20010016665A1 (en) 2001-08-23
DE69617948D1 (de) 2002-01-24
CZ296895B6 (cs) 2006-07-12
EE04053B1 (et) 2003-06-16
HU0500934D0 (en) 2005-12-28
NZ501628A (en) 2001-09-28
HU229957B1 (hu) 2015-03-30
DK0830338T3 (da) 2002-04-02
JP3874306B2 (ja) 2007-01-31
AU700091B2 (en) 1998-12-24
US5637767A (en) 1997-06-10
ATE210628T1 (de) 2001-12-15
NZ308319A (en) 2000-02-28
PL323795A1 (en) 1998-04-27
HUP9802504A2 (hu) 1999-02-01
CZ291147B6 (cs) 2002-12-11
HU228194B1 (en) 2013-01-28
AU5792196A (en) 1996-12-30
SK164597A3 (en) 1998-05-06
DE69617948T2 (de) 2002-06-13
CA2219150A1 (en) 1996-12-19
SK283507B6 (sk) 2003-08-05
CZ384697A3 (cs) 1998-03-18
PL185557B1 (pl) 2003-06-30
PT830338E (pt) 2002-04-29
US6046353A (en) 2000-04-04
US5840956A (en) 1998-11-24
HUP9802504A3 (en) 2000-06-28
EP0830338B1 (en) 2001-12-12
PL185425B1 (pl) 2003-05-30
ES2170231T3 (es) 2002-08-01
EE9700320A (et) 1998-06-15
GEP19991870B (en) 1999-12-06
EP0830338A1 (en) 1998-03-25
SK282865B6 (sk) 2003-01-09
PL185560B1 (pl) 2003-06-30
JPH11506726A (ja) 1999-06-15
MX9708652A (es) 1998-06-30
CA2219150C (en) 2008-11-18
WO1996040617A1 (en) 1996-12-19

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