SI0830338T1 - Method of making 3-(aminomethyl)-5-methylhexanoic acid - Google Patents

Method of making 3-(aminomethyl)-5-methylhexanoic acid

Info

Publication number
SI0830338T1
SI0830338T1 SI9630390T SI9630390T SI0830338T1 SI 0830338 T1 SI0830338 T1 SI 0830338T1 SI 9630390 T SI9630390 T SI 9630390T SI 9630390 T SI9630390 T SI 9630390T SI 0830338 T1 SI0830338 T1 SI 0830338T1
Authority
SI
Slovenia
Prior art keywords
aminomethyl
methylhexanoic acid
alkali
earth metal
alkaline earth
Prior art date
Application number
SI9630390T
Other languages
English (en)
Slovenian (sl)
Inventor
Todd Michel Grote
Brian Keith Huckabee
Thomas Mulhern
Denis Martin Sobieray
Robert Daniel Titus
Original Assignee
Warner-Lambert Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner-Lambert Company filed Critical Warner-Lambert Company
Publication of SI0830338T1 publication Critical patent/SI0830338T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/34—Preparation of optical isomers by separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/10—Formation of amino groups in compounds containing carboxyl groups with simultaneously increasing the number of carbon atoms in the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C07C255/22—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton containing cyano groups and at least two carboxyl groups bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Seasonings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SI9630390T 1995-06-07 1996-05-13 Method of making 3-(aminomethyl)-5-methylhexanoic acid SI0830338T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/474,874 US5637767A (en) 1995-06-07 1995-06-07 Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid
PCT/US1996/006819 WO1996040617A1 (en) 1995-06-07 1996-05-13 Method of making (s)-3-(aminomethyl)-5-methylhexanoic acid
EP96914618A EP0830338B1 (en) 1995-06-07 1996-05-13 Method of making 3-(aminomethyl)-5-methylhexanoic acid

Publications (1)

Publication Number Publication Date
SI0830338T1 true SI0830338T1 (en) 2002-04-30

Family

ID=23885291

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9630390T SI0830338T1 (en) 1995-06-07 1996-05-13 Method of making 3-(aminomethyl)-5-methylhexanoic acid

Country Status (18)

Country Link
US (4) US5637767A (cs)
EP (1) EP0830338B1 (cs)
JP (1) JP3874306B2 (cs)
AT (1) ATE210628T1 (cs)
CA (1) CA2219150C (cs)
CZ (2) CZ291147B6 (cs)
DE (1) DE69617948T2 (cs)
DK (1) DK0830338T3 (cs)
EE (1) EE04053B1 (cs)
ES (1) ES2170231T3 (cs)
GE (1) GEP19991870B (cs)
HU (2) HU229957B1 (cs)
NZ (2) NZ501628A (cs)
PL (3) PL185425B1 (cs)
PT (1) PT830338E (cs)
SI (1) SI0830338T1 (cs)
SK (2) SK283507B6 (cs)
WO (1) WO1996040617A1 (cs)

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UA82292C2 (uk) * 2004-04-14 2008-03-25 Пфайзер Продактс Инк. Спосіб стереоселективного біоперетворення аліфатичних динітрилів в ціанокарбонові кислоти (варіанти)
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WO2006121557A1 (en) * 2005-05-10 2006-11-16 Teva Pharmaceutical Industries Ltd. Pregabalin free of lactam and a process for preparation thereof
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KR20080036060A (ko) 2006-05-31 2008-04-24 테바 파마슈티컬 인더스트리즈 리미티드 프레가발린의 중간체의 제조에 효소 분할을 이용하는 방법
EP1912931A2 (en) * 2006-05-31 2008-04-23 Teva Pharmaceutical Industries Ltd. Preparation of (s)-pregabalin-nitrile
AU2007274034B2 (en) * 2006-07-12 2012-11-15 Generics [Uk] Limited Process of preparing a gamma-amino acid
WO2008062460A2 (en) * 2006-10-06 2008-05-29 Cadila Healthcare Limited Crystalline forms of pregabalin
EP2021318A2 (en) * 2007-03-22 2009-02-11 Teva Pharmaceutical Industries Ltd. Synthesis of (s)-(+)-3-(aminomethyl)-5-methyl hexanoic acid
WO2008138874A1 (en) * 2007-05-09 2008-11-20 Chemo Ibérica, S.A. Process for preparing (s)-pregabalin by optical resolution of racemic pregabalin
EP1992609A1 (en) * 2007-05-14 2008-11-19 Dipharma Francis S.r.l. A process for the preparation of a (S)(+)-3-(aminomethyl)-5-methylhexanoic acid
EP2170813A4 (en) * 2007-06-25 2012-05-16 Reddy Manne Satyanarayana NEW METHOD OF PREPARING PREGABALIN
WO2009044409A2 (en) * 2007-10-01 2009-04-09 Natco Pharma Limited Novel resolution process for pregabalin
KR20090101462A (ko) * 2007-10-03 2009-09-28 테바 파마슈티컬 인더스트리즈 리미티드 프레가발린-4-엘리미네이트, 프레가발린 5-엘리미네이트, 기준 마커 및 표준물로서의 이들의 용도, 및 이들을 낮은 수준으로 함유하는 프레가발린의 제조 방법
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CN101965328A (zh) * 2007-12-26 2011-02-02 基因里克斯(英国)有限公司 普瑞巴林的制备方法
KR101489267B1 (ko) 2007-12-27 2015-02-04 도오레 화인케미칼 가부시키가이샤 광학 활성 3-아미노피롤리딘염, 그 제조 방법 및 3-아미노피롤리딘의 광학 분할 방법
WO2009082861A1 (fr) * 2008-01-02 2009-07-09 Zhejiang Jiuzhou Pharmaceutical Co., Ltd. Nouveau procédé de dédoublement de l'acide (s)-3-aminométhyl-5-méthylhexanoïque
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EP2110372A1 (en) 2008-04-16 2009-10-21 Chemo Ibérica, S.A. Intermediates for the preparation of Pregabalin and process for their preparation
CN101585778B (zh) * 2008-05-19 2014-08-13 上海臣邦医药科技有限公司 一种普瑞巴林制备方法
MX2010012698A (es) * 2008-05-21 2011-03-15 Sandoz Ag Proceso para la hidrolisis enzimatica estereoselectiva del ester del acido 5-metil-3-nitro-metil-hexanoico.
CN102112436A (zh) * 2008-06-03 2011-06-29 基因里克斯(英国)有限公司 用于合成氨基酸的新的和有效方法
US20100087525A1 (en) * 2008-06-23 2010-04-08 Lilach Hedvati Stereoselective enzymatic synthesis of (s) or (r)-iso-butyl-glutaric ester
WO2010061403A2 (en) * 2008-11-26 2010-06-03 Ind-Swift Laboratories Limited Process to prepare highly pure (s)-pregabalin
WO2010070593A2 (en) 2008-12-19 2010-06-24 Pfizer Ireland Pharmaceuticals Malonate esters
IT1394292B1 (it) 2009-05-07 2012-06-06 Dipharma Francis Srl Procedimento per la sintesi di pregabalina
ES2362913B1 (es) 2009-12-24 2012-05-24 Moehs Iberica S.L. Nuevo método para la preparación de (s)-pregabalina.
HUP1000186A2 (en) 2010-04-08 2011-10-28 Richter Gedeon Nyrt Novel industrial process of preparing (s)-(+) pregabalin
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US8212072B2 (en) 2010-08-13 2012-07-03 Divi's Laboratories, Ltd. Process for the preparation of pregabalin
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CN103980144B (zh) * 2014-05-16 2018-08-17 浙江华海药业股份有限公司 一种普瑞巴林中间体母液的套用方法
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CN104086439B (zh) * 2014-06-30 2018-11-16 浙江华海药业股份有限公司 一种pregabalin中间体拆分剂(R)-(+)-α-苯乙胺的回收方法
WO2016075082A1 (en) 2014-11-10 2016-05-19 Sandoz Ag Stereoselective reductive amination of alpha-chiral aldehydes using omega-transaminases for the synthesis of precursors of pregabalin and brivaracetam
CN104649919B (zh) * 2015-02-10 2021-02-12 浙江华海药业股份有限公司 一种小颗粒普瑞巴林的制备方法
JP2018520112A (ja) 2015-05-26 2018-07-26 オディディ，イサ 制御持続放出プレガバリン
CN105175276A (zh) * 2015-07-25 2015-12-23 安徽东凯生物科技有限公司 一种光学纯(r)-3-氨甲酰甲基-5-甲基己酸的合成方法
CN105061234A (zh) * 2015-08-18 2015-11-18 太仓运通生物化工有限公司 一种制备普瑞巴林的方法
CN105085290A (zh) * 2015-08-18 2015-11-25 太仓运通生物化工有限公司 一种合成普瑞巴林的方法
CN105348125A (zh) * 2015-11-26 2016-02-24 太仓运通生物化工有限公司 一种以异戊醛为原料合成普瑞巴林的方法
CN111333529A (zh) * 2018-12-19 2020-06-26 北京万全德众医药生物技术有限公司 普瑞巴林的一种制备方法
CN109942446B (zh) * 2019-04-17 2021-09-07 黄冈鲁班药业股份有限公司 一种普瑞巴林的制备方法
EP4230199A4 (en) 2020-12-04 2024-07-31 Laboratorios Silanes S A De C V COATED AND STABLE SOLID PHARMACEUTICAL COMPOSITION OF AN ANALGESIC AND AN ANTIEPILEPTIC AGAINST PAIN
CN112939809A (zh) * 2020-12-30 2021-06-11 江苏恒沛药物科技有限公司 一种1-氰基-3-甲基丁基丙二酸二乙酯的制备方法
CN116041214A (zh) * 2022-11-15 2023-05-02 奥锐特药业股份有限公司 一种普瑞巴林中间体的制备方法及其应用

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Also Published As

Publication number Publication date
GEP19991870B (en) 1999-12-06
EP0830338B1 (en) 2001-12-12
HUP9802504A2 (hu) 1999-02-01
HU0500934D0 (en) 2005-12-28
SK164597A3 (en) 1998-05-06
JP3874306B2 (ja) 2007-01-31
NZ308319A (en) 2000-02-28
PL323795A1 (en) 1998-04-27
SK283507B6 (sk) 2003-08-05
EE9700320A (et) 1998-06-15
NZ501628A (en) 2001-09-28
US5637767A (en) 1997-06-10
ATE210628T1 (de) 2001-12-15
AU5792196A (en) 1996-12-30
EP0830338A1 (en) 1998-03-25
PL185425B1 (pl) 2003-05-30
SK282865B6 (sk) 2003-01-09
EE04053B1 (et) 2003-06-16
WO1996040617A1 (en) 1996-12-19
CZ384697A3 (cs) 1998-03-18
PL185560B1 (pl) 2003-06-30
CA2219150C (en) 2008-11-18
CZ296895B6 (cs) 2006-07-12
US20010016665A1 (en) 2001-08-23
CZ291147B6 (cs) 2002-12-11
HU228194B1 (en) 2013-01-28
PL185557B1 (pl) 2003-06-30
US6046353A (en) 2000-04-04
US5840956A (en) 1998-11-24
JPH11506726A (ja) 1999-06-15
AU700091B2 (en) 1998-12-24
ES2170231T3 (es) 2002-08-01
HUP9802504A3 (en) 2000-06-28
HU229957B1 (hu) 2015-03-30
DK0830338T3 (da) 2002-04-02
DE69617948D1 (de) 2002-01-24
PT830338E (pt) 2002-04-29
DE69617948T2 (de) 2002-06-13
MX9708652A (es) 1998-06-30
CA2219150A1 (en) 1996-12-19

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