ES2170231T3 - Metodo para producir el acido 3-(aminometil)-5-metilhexanoico. - Google Patents

Metodo para producir el acido 3-(aminometil)-5-metilhexanoico.

Info

Publication number
ES2170231T3
ES2170231T3 ES96914618T ES96914618T ES2170231T3 ES 2170231 T3 ES2170231 T3 ES 2170231T3 ES 96914618 T ES96914618 T ES 96914618T ES 96914618 T ES96914618 T ES 96914618T ES 2170231 T3 ES2170231 T3 ES 2170231T3
Authority
ES
Spain
Prior art keywords
alcali
iii
less
metal
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96914618T
Other languages
English (en)
Inventor
Todd Michel Grote
Brian Keith Huckabee
Thomas Mulhern
Denis Martin Sobieray
Robert Daniel Titus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Application granted granted Critical
Publication of ES2170231T3 publication Critical patent/ES2170231T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/34—Preparation of optical isomers by separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/10—Formation of amino groups in compounds containing carboxyl groups with simultaneously increasing the number of carbon atoms in the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C07C255/22—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton containing cyano groups and at least two carboxyl groups bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Seasonings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE DESCRIBE UN PROCEDIMIENTO PARA PREPARAR ( (MAS MENOS) ) EL ISOVALERALDEHIDO CON (II) PARA FORMAR PRINCIPALMENTE (III); HACER REACCIONAR EL (III) CON UNA FUENTE DE CIANURO PARA FORMAR (IV); DESCARBOXILAR EL (IV) PARA FORMAR (V); HIDROLIZAR EL (V) CON UN ALCALI O UN HIDROXIDO DE METAL ALCALINO FORMAR UN ALCALI O LA SAL CARBOXILATO DE METAL ALCALINO EO; E HIDROGENAR EL ALCALI O LA SAL CARBOXILATO DE METAL ALCALINO TERREO PARA FORMAR EL ACIDO ( (MAS MENOS) ) TIL) ,6}, ARILO, BENCILO O CICLOALQUILO C SUB,3} SENTE INVENCION TAMBIEN DESCRIBE UN PROCEDIMIENTO PARA PRODUCIR ACIDO ( (MAS MENOS) ) UE INCLUYE CONDENSAR EL ISOVALERALDEHIDO CON (II) PARA FORMAR PRINCIPALMENTE (III); HACER REACCIONAR EL (III) CON UNA FUENTE DE CIANURO PARA FORMAR (IV); DESCARBOXILAR EL (IV) PARA FORMAR UN ALCALI O UNA SAL CARBOXILATO DE METAL ALCALINO HIDROGENAR EL ALCALI O LA SAL CARBOXILATO DE METAL ALCALINO TERREO PARA FORMAR EL ACIDO ( (MAS MENOS) ) 3 -(AMINOMETIL) 5
ES96914618T 1995-06-07 1996-05-13 Metodo para producir el acido 3-(aminometil)-5-metilhexanoico. Expired - Lifetime ES2170231T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/474,874 US5637767A (en) 1995-06-07 1995-06-07 Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid

Publications (1)

Publication Number Publication Date
ES2170231T3 true ES2170231T3 (es) 2002-08-01

Family

ID=23885291

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96914618T Expired - Lifetime ES2170231T3 (es) 1995-06-07 1996-05-13 Metodo para producir el acido 3-(aminometil)-5-metilhexanoico.

Country Status (18)

Country Link
US (4) US5637767A (es)
EP (1) EP0830338B1 (es)
JP (1) JP3874306B2 (es)
AT (1) ATE210628T1 (es)
CA (1) CA2219150C (es)
CZ (2) CZ296895B6 (es)
DE (1) DE69617948T2 (es)
DK (1) DK0830338T3 (es)
EE (1) EE04053B1 (es)
ES (1) ES2170231T3 (es)
GE (1) GEP19991870B (es)
HU (2) HU229957B1 (es)
NZ (2) NZ308319A (es)
PL (3) PL185557B1 (es)
PT (1) PT830338E (es)
SI (1) SI0830338T1 (es)
SK (2) SK282865B6 (es)
WO (1) WO1996040617A1 (es)

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DE602005002253T2 (de) * 2004-03-12 2008-05-29 Warner-Lambert Company Llc C1-symmetrische bisphosphinliganden und deren verwendung bei der asymmetrischen synthese von pregabalin
UA82292C2 (uk) * 2004-04-14 2008-03-25 Пфайзер Продактс Инк. Спосіб стереоселективного біоперетворення аліфатичних динітрилів в ціанокарбонові кислоти (варіанти)
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US20080015385A1 (en) * 2006-05-31 2008-01-17 Lilach Hedvati Preparation of (S)-pregabalin-nitrile
CA2657544C (en) * 2006-07-12 2013-05-28 Generics [Uk] Limited Process for preparing pregabalin
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CN101585778B (zh) * 2008-05-19 2014-08-13 上海臣邦医药科技有限公司 一种普瑞巴林制备方法
CN102099482B (zh) * 2008-05-21 2014-04-16 桑多斯股份公司 5-甲基-3-硝基甲基-己酸酯的立体选择性酶水解方法
CA2723871A1 (en) * 2008-06-03 2009-12-10 Generics [Uk] Limited Process for the synthesis of .gamma. -amino acids
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WO2010061403A2 (en) * 2008-11-26 2010-06-03 Ind-Swift Laboratories Limited Process to prepare highly pure (s)-pregabalin
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CN104649919B (zh) * 2015-02-10 2021-02-12 浙江华海药业股份有限公司 一种小颗粒普瑞巴林的制备方法
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CN105061234A (zh) * 2015-08-18 2015-11-18 太仓运通生物化工有限公司 一种制备普瑞巴林的方法
CN105085290A (zh) * 2015-08-18 2015-11-25 太仓运通生物化工有限公司 一种合成普瑞巴林的方法
CN105348125A (zh) * 2015-11-26 2016-02-24 太仓运通生物化工有限公司 一种以异戊醛为原料合成普瑞巴林的方法
CN111333529A (zh) * 2018-12-19 2020-06-26 北京万全德众医药生物技术有限公司 普瑞巴林的一种制备方法
CN109942446B (zh) * 2019-04-17 2021-09-07 黄冈鲁班药业股份有限公司 一种普瑞巴林的制备方法
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Also Published As

Publication number Publication date
NZ308319A (en) 2000-02-28
PL323795A1 (en) 1998-04-27
US5637767A (en) 1997-06-10
NZ501628A (en) 2001-09-28
DE69617948D1 (de) 2002-01-24
EE9700320A (et) 1998-06-15
SK283507B6 (sk) 2003-08-05
US20010016665A1 (en) 2001-08-23
JP3874306B2 (ja) 2007-01-31
DE69617948T2 (de) 2002-06-13
HU228194B1 (en) 2013-01-28
EP0830338B1 (en) 2001-12-12
HU229957B1 (hu) 2015-03-30
CZ291147B6 (cs) 2002-12-11
JPH11506726A (ja) 1999-06-15
PT830338E (pt) 2002-04-29
MX9708652A (es) 1998-06-30
HU0500934D0 (en) 2005-12-28
DK0830338T3 (da) 2002-04-02
US5840956A (en) 1998-11-24
EE04053B1 (et) 2003-06-16
US6046353A (en) 2000-04-04
CZ384697A3 (cs) 1998-03-18
SK282865B6 (sk) 2003-01-09
CA2219150A1 (en) 1996-12-19
ATE210628T1 (de) 2001-12-15
HUP9802504A3 (en) 2000-06-28
PL185557B1 (pl) 2003-06-30
CZ296895B6 (cs) 2006-07-12
PL185560B1 (pl) 2003-06-30
HUP9802504A2 (hu) 1999-02-01
SK164597A3 (en) 1998-05-06
AU5792196A (en) 1996-12-30
CA2219150C (en) 2008-11-18
AU700091B2 (en) 1998-12-24
PL185425B1 (pl) 2003-05-30
SI0830338T1 (en) 2002-04-30
WO1996040617A1 (en) 1996-12-19
GEP19991870B (en) 1999-12-06
EP0830338A1 (en) 1998-03-25

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