EE04053B1 - (S)-3-(aminometüül)-5-metüülheksaanhappe valmistamise meetod - Google Patents

(S)-3-(aminometüül)-5-metüülheksaanhappe valmistamise meetod

Info

Publication number
EE04053B1
EE04053B1 EE9700320A EE9700320A EE04053B1 EE 04053 B1 EE04053 B1 EE 04053B1 EE 9700320 A EE9700320 A EE 9700320A EE 9700320 A EE9700320 A EE 9700320A EE 04053 B1 EE04053 B1 EE 04053B1
Authority
EE
Estonia
Prior art keywords
aminomethyl
methylhexanoic acid
alkali
earth metal
alkaline earth
Prior art date
Application number
EE9700320A
Other languages
English (en)
Estonian (et)
Other versions
EE9700320A (et
Inventor
Michel Grote Todd
Keith Huckabee Brian
Martin Sobieray Denis
Daniel Titus Robert
Mulhern Thomas
Original Assignee
Warner-Lambert Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner-Lambert Company filed Critical Warner-Lambert Company
Publication of EE9700320A publication Critical patent/EE9700320A/xx
Publication of EE04053B1 publication Critical patent/EE04053B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/34—Preparation of optical isomers by separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/10—Formation of amino groups in compounds containing carboxyl groups with simultaneously increasing the number of carbon atoms in the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C07C255/22—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton containing cyano groups and at least two carboxyl groups bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Seasonings (AREA)
EE9700320A 1995-06-07 1996-05-13 (S)-3-(aminometüül)-5-metüülheksaanhappe valmistamise meetod EE04053B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/474,874 US5637767A (en) 1995-06-07 1995-06-07 Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid
PCT/US1996/006819 WO1996040617A1 (en) 1995-06-07 1996-05-13 Method of making (s)-3-(aminomethyl)-5-methylhexanoic acid

Publications (2)

Publication Number Publication Date
EE9700320A EE9700320A (et) 1998-06-15
EE04053B1 true EE04053B1 (et) 2003-06-16

Family

ID=23885291

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9700320A EE04053B1 (et) 1995-06-07 1996-05-13 (S)-3-(aminometüül)-5-metüülheksaanhappe valmistamise meetod

Country Status (18)

Country Link
US (4) US5637767A (es)
EP (1) EP0830338B1 (es)
JP (1) JP3874306B2 (es)
AT (1) ATE210628T1 (es)
CA (1) CA2219150C (es)
CZ (2) CZ291147B6 (es)
DE (1) DE69617948T2 (es)
DK (1) DK0830338T3 (es)
EE (1) EE04053B1 (es)
ES (1) ES2170231T3 (es)
GE (1) GEP19991870B (es)
HU (2) HU229957B1 (es)
NZ (2) NZ308319A (es)
PL (3) PL185425B1 (es)
PT (1) PT830338E (es)
SI (1) SI0830338T1 (es)
SK (2) SK282865B6 (es)
WO (1) WO1996040617A1 (es)

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US6194459B1 (en) 1997-08-19 2001-02-27 Warner-Lambert Company Methods for treating physiological conditions associated with the use, or sequelae of use, of cocaine or other psychomotors stimulants
GEP20074142B (en) * 1999-06-10 2007-07-10 Warner Lambert Co Mono- and Disubstituted 3-Propyl Gamma-Aminobutyric Acids
HU228815B1 (en) * 2000-01-27 2013-05-28 Warner Lambert Co Asymmetric synthesis of pregabalin
GB2368579A (en) * 2000-10-31 2002-05-08 Parke Davis & Co Ltd Azole pharmaceutical agents
US7169812B2 (en) * 2003-07-01 2007-01-30 Medtronic, Inc. Process for producing injectable gabapentin compositions
EP1543831A1 (en) * 2003-12-18 2005-06-22 Pfizer GmbH Arzneimittelwerk Gödecke Pregabalin composition
ES2292107T3 (es) * 2004-03-12 2008-03-01 Warner-Lambert Company Llc Ligandos de bifosfina simetricos en c1 y su uso en la sintesis asimetrica de pregabalina.
UA82292C2 (uk) * 2004-04-14 2008-03-25 Пфайзер Продактс Инк. Спосіб стереоселективного біоперетворення аліфатичних динітрилів в ціанокарбонові кислоти (варіанти)
DK1831154T3 (da) * 2004-06-21 2010-04-12 Warner Lambert Co Fremstilling af pregabalin og relaterede forbindelser
CN101160281A (zh) * 2005-04-06 2008-04-09 特瓦制药工业有限公司 结晶形态的普瑞巴林
CN101300224A (zh) * 2005-04-11 2008-11-05 特瓦制药工业有限公司 制备(s)-普瑞巴林的方法
US7488846B2 (en) * 2005-04-11 2009-02-10 Teva Pharmaceuical Industries Ltd. Pregabalin free of lactam and a process for preparation thereof
MX2007000525A (es) * 2005-05-10 2007-03-28 Teva Pharma Pregabalina libre de acido isobutilglutarico y un proceso para la preparacion de ella.
EP1879852A1 (en) * 2005-05-10 2008-01-23 Teva Pharmaceutical Industries Ltd Pregabalin free of lactam and a process for preparation thereof
DE602006017995D1 (de) * 2005-05-10 2010-12-16 Teva Pharma Verfahren zur herstellung von pregabalin und salzen daraus
EP1879854B1 (en) * 2005-05-10 2011-09-07 Teva Pharmaceutical Industries Ltd Optical resolution of 3-carbamoylmethyl-5-methyl hexanoic acid
WO2007035890A1 (en) * 2005-09-19 2007-03-29 Teva Pharmaceutical Industries Ltd. An asymmetric synthesis of ( s ) - ( + ) -3- (aminomethyl) -5-methylhexanoic acid
NL2000281C2 (nl) 2005-11-02 2007-08-07 Pfizer Prod Inc Vaste farmaceutische samenstellingen die pregabaline bevatten.
US20070259917A1 (en) * 2006-04-24 2007-11-08 Kansal Vinod K Processes for the synthesis of 3-isobutylglutaric acid
US7462738B2 (en) * 2006-05-24 2008-12-09 Teva Pharmaceutical Industries Ltd. Processes for the preparation of R-(+)-3-(carbamoyl methyl)-5-methylhexanoic acid and salts thereof
EP2071032A3 (en) 2006-05-31 2009-07-08 Teva Pharmaceutical Industries Ltd The use of enzymatic resolution for the preparation of intermediates of pregabalin
WO2007143152A2 (en) * 2006-05-31 2007-12-13 Teva Pharmaceutical Industries Ltd. Preparation of (s)-pregabalin-nitrile
US20090286880A1 (en) * 2006-07-12 2009-11-19 Generics [Uk] Limited Novel process
WO2008062460A2 (en) * 2006-10-06 2008-05-29 Cadila Healthcare Limited Crystalline forms of pregabalin
MX2008014759A (es) * 2007-03-22 2009-03-09 Teva Pharma Sintesis del acido (s)-(+)-3-(aminometil)-5-metil hexanoico.
WO2008138874A1 (en) * 2007-05-09 2008-11-20 Chemo Ibérica, S.A. Process for preparing (s)-pregabalin by optical resolution of racemic pregabalin
EP1992609A1 (en) * 2007-05-14 2008-11-19 Dipharma Francis S.r.l. A process for the preparation of a (S)(+)-3-(aminomethyl)-5-methylhexanoic acid
EP2170813A4 (en) * 2007-06-25 2012-05-16 Reddy Manne Satyanarayana NEW METHOD OF PREPARING PREGABALIN
WO2009044409A2 (en) * 2007-10-01 2009-04-09 Natco Pharma Limited Novel resolution process for pregabalin
KR20090101462A (ko) * 2007-10-03 2009-09-28 테바 파마슈티컬 인더스트리즈 리미티드 프레가발린-4-엘리미네이트, 프레가발린 5-엘리미네이트, 기준 마커 및 표준물로서의 이들의 용도, 및 이들을 낮은 수준으로 함유하는 프레가발린의 제조 방법
ITMI20072262A1 (it) 2007-12-03 2009-06-04 Dipharma Francis Srl Procedimento per la preparazione di acido (s)(+)-3-(amminometil)-5-metilesanoico
WO2009087674A2 (en) * 2007-12-18 2009-07-16 Watson Pharma Private Limited Improved process for the preparation of (s)-pregabalin
CA2710152A1 (en) * 2007-12-26 2009-07-02 Generics (Uk) Limited Processes to pregabalin
WO2009084493A1 (ja) * 2007-12-27 2009-07-09 Toray Fine Chemicals Co., Ltd. 光学活性３－アミノピロリジン塩及びその製造方法並びに３－アミノピロリジンの光学分割方法
DE112008003594B4 (de) 2008-01-02 2018-04-26 Zhejiang Jiuzhou Pharmaceutical Co., Ltd. Neues Abtrennverfahren von S-3-Aminomethyl-5-Methylhexansäure
WO2009125427A2 (en) * 2008-02-18 2009-10-15 Matrix Laboratories Limited Process for preparing (s)-3-(aminomethyl)-5-methylhexanoic acid
NZ588894A (en) * 2008-04-04 2012-12-21 Process for preparing (s)-pregabalin by chiral resolution
EP2110372A1 (en) 2008-04-16 2009-10-21 Chemo Ibérica, S.A. Intermediates for the preparation of Pregabalin and process for their preparation
CN101585778B (zh) * 2008-05-19 2014-08-13 上海臣邦医药科技有限公司 一种普瑞巴林制备方法
CA2724828C (en) * 2008-05-21 2016-01-12 Sandoz Ag Process for the stereoselective enzymatic hydrolysis of 5-methyl-3-nitromethyl-hexanoic acid ester
CA2723871A1 (en) * 2008-06-03 2009-12-10 Generics [Uk] Limited Process for the synthesis of .gamma. -amino acids
KR20100107500A (ko) * 2008-06-23 2010-10-05 테바 파마슈티컬 인더스트리즈 리미티드 (ｓ) 또는 (ｒ)-이소-부틸-글루타릭 에스테르의 입체선택적 효소 합성방법
WO2010061403A2 (en) * 2008-11-26 2010-06-03 Ind-Swift Laboratories Limited Process to prepare highly pure (s)-pregabalin
WO2010070593A2 (en) 2008-12-19 2010-06-24 Pfizer Ireland Pharmaceuticals Malonate esters
IT1394292B1 (it) 2009-05-07 2012-06-06 Dipharma Francis Srl Procedimento per la sintesi di pregabalina
ES2362913B1 (es) 2009-12-24 2012-05-24 Moehs Iberica S.L. Nuevo método para la preparación de (s)-pregabalina.
HUP1000186A2 (en) * 2010-04-08 2011-10-28 Richter Gedeon Nyrt Novel industrial process of preparing (s)-(+) pregabalin
WO2011141923A2 (en) 2010-05-14 2011-11-17 Lupin Limited Improved synthesis of optically pure (s) - 3-cyano-5-methyl-hexanoic acid alkyl ester, an intermediate of (s)- pregabalin
US8212072B2 (en) 2010-08-13 2012-07-03 Divi's Laboratories, Ltd. Process for the preparation of pregabalin
WO2012025861A1 (en) 2010-08-23 2012-03-01 Pfizer Manufacturing Ireland Process for the preparation of ( s ) - 3 - cyano - 5 - methylhexanoic acid derivatives adn of pregabalin
WO2012144551A1 (ja) 2011-04-20 2012-10-26 財団法人乙卯研究所 ケイ素含有カルボン酸誘導体
EP2527319A1 (en) 2011-05-24 2012-11-28 Laboratorios Del. Dr. Esteve, S.A. Crystalline forms of pregabalin and co-formers in the treatment of pain
WO2014061714A1 (ja) 2012-10-18 2014-04-24 公益財団法人乙卯研究所 ケイ素含有カルボン酸誘導体
CA2888877C (en) 2012-11-07 2021-07-27 Hikal Limited A process for the preparation of pregabalin
CN103980144B (zh) * 2014-05-16 2018-08-17 浙江华海药业股份有限公司 一种普瑞巴林中间体母液的套用方法
EP3154930B1 (en) 2014-06-12 2018-04-18 Siegfried Ltd. Method for the preparation of beta-substituted gamma-amino carboxylic acids
CN104086439B (zh) * 2014-06-30 2018-11-16 浙江华海药业股份有限公司 一种pregabalin中间体拆分剂(R)-(+)-α-苯乙胺的回收方法
WO2016075082A1 (en) 2014-11-10 2016-05-19 Sandoz Ag Stereoselective reductive amination of alpha-chiral aldehydes using omega-transaminases for the synthesis of precursors of pregabalin and brivaracetam
CN104649919B (zh) * 2015-02-10 2021-02-12 浙江华海药业股份有限公司 一种小颗粒普瑞巴林的制备方法
WO2016187718A1 (en) 2015-05-26 2016-12-01 Isa Odidi Controlled extended release pregabalin
CN105175276A (zh) * 2015-07-25 2015-12-23 安徽东凯生物科技有限公司 一种光学纯(r)-3-氨甲酰甲基-5-甲基己酸的合成方法
CN105085290A (zh) * 2015-08-18 2015-11-25 太仓运通生物化工有限公司 一种合成普瑞巴林的方法
CN105061234A (zh) * 2015-08-18 2015-11-18 太仓运通生物化工有限公司 一种制备普瑞巴林的方法
CN105348125A (zh) * 2015-11-26 2016-02-24 太仓运通生物化工有限公司 一种以异戊醛为原料合成普瑞巴林的方法
CN111333529A (zh) * 2018-12-19 2020-06-26 北京万全德众医药生物技术有限公司 普瑞巴林的一种制备方法
CN109942446B (zh) * 2019-04-17 2021-09-07 黄冈鲁班药业股份有限公司 一种普瑞巴林的制备方法
KR20230117591A (ko) 2020-12-04 2023-08-08 라보라토리오스 실레인즈, 에스.에이. 드 씨.브이. 통증 경감을 위한 오피오이드 진통제 및 항경련제를함유하는 안정한 코팅된, 고형의 약학적 조성물
CN112939809A (zh) * 2020-12-30 2021-06-11 江苏恒沛药物科技有限公司 一种1-氰基-3-甲基丁基丙二酸二乙酯的制备方法
CN116041214A (zh) * 2022-11-15 2023-05-02 奥锐特药业股份有限公司 一种普瑞巴林中间体的制备方法及其应用

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JPS54100316A (en) * 1978-01-25 1979-08-08 Meiji Seika Kaisha Ltd Preparation of derivative of aminobutyric acid
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Also Published As

Publication number Publication date
PL185425B1 (pl) 2003-05-30
CZ296895B6 (cs) 2006-07-12
SK283507B6 (sk) 2003-08-05
ES2170231T3 (es) 2002-08-01
DE69617948T2 (de) 2002-06-13
PL185560B1 (pl) 2003-06-30
SK164597A3 (en) 1998-05-06
DK0830338T3 (da) 2002-04-02
HUP9802504A3 (en) 2000-06-28
CZ384697A3 (cs) 1998-03-18
US5637767A (en) 1997-06-10
PL185557B1 (pl) 2003-06-30
HU0500934D0 (en) 2005-12-28
MX9708652A (es) 1998-06-30
US20010016665A1 (en) 2001-08-23
CA2219150C (en) 2008-11-18
SI0830338T1 (en) 2002-04-30
EP0830338B1 (en) 2001-12-12
JPH11506726A (ja) 1999-06-15
HUP9802504A2 (hu) 1999-02-01
WO1996040617A1 (en) 1996-12-19
NZ308319A (en) 2000-02-28
PL323795A1 (en) 1998-04-27
CZ291147B6 (cs) 2002-12-11
JP3874306B2 (ja) 2007-01-31
AU5792196A (en) 1996-12-30
DE69617948D1 (de) 2002-01-24
SK282865B6 (sk) 2003-01-09
US5840956A (en) 1998-11-24
CA2219150A1 (en) 1996-12-19
PT830338E (pt) 2002-04-29
HU229957B1 (hu) 2015-03-30
NZ501628A (en) 2001-09-28
EP0830338A1 (en) 1998-03-25
US6046353A (en) 2000-04-04
AU700091B2 (en) 1998-12-24
HU228194B1 (en) 2013-01-28
ATE210628T1 (de) 2001-12-15
GEP19991870B (en) 1999-12-06
EE9700320A (et) 1998-06-15

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