AU3126900A - Alpha-substitution of unprotected beta-amino ester compounds - Google Patents

Alpha-substitution of unprotected beta-amino ester compounds

Info

Publication number
AU3126900A
AU3126900A AU31269/00A AU3126900A AU3126900A AU 3126900 A AU3126900 A AU 3126900A AU 31269/00 A AU31269/00 A AU 31269/00A AU 3126900 A AU3126900 A AU 3126900A AU 3126900 A AU3126900 A AU 3126900A
Authority
AU
Australia
Prior art keywords
alpha
substitution
amino ester
ester compounds
lithium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU31269/00A
Inventor
Sithamalli V. Chandramouli
Michael K. O'brien
Tory H. Powner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Aventis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharmaceuticals Inc filed Critical Aventis Pharmaceuticals Inc
Publication of AU3126900A publication Critical patent/AU3126900A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C261/00—Derivatives of cyanic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrrole Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

Methods for stereoselective substitution in which a (mono or un)-alpha-substituted unprotected beta-amino ester compound or salt thereof is reacted with an aliphatic electrophile in the presence of a base selected from alkyl lithium compounds, lithium hydride, lithium amide, lithium dialkyl amides and alkali hexamethyldisilylamines.
AU31269/00A 1998-12-31 1999-12-17 Alpha-substitution of unprotected beta-amino ester compounds Abandoned AU3126900A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11459898P 1998-12-31 1998-12-31
US60114598 1998-12-31
PCT/US1999/030366 WO2000040547A1 (en) 1998-12-31 1999-12-17 α-SUBSTITUTION OF UNPROTECTED β-AMINO ESTER COMPOUNDS

Publications (1)

Publication Number Publication Date
AU3126900A true AU3126900A (en) 2000-07-24

Family

ID=22356227

Family Applications (1)

Application Number Title Priority Date Filing Date
AU31269/00A Abandoned AU3126900A (en) 1998-12-31 1999-12-17 Alpha-substitution of unprotected beta-amino ester compounds

Country Status (15)

Country Link
US (1) US6433209B1 (en)
EP (1) EP1144367B1 (en)
JP (1) JP4771442B2 (en)
KR (1) KR100657780B1 (en)
CN (1) CN1173938C (en)
AT (1) ATE277896T1 (en)
AU (1) AU3126900A (en)
BR (1) BR9916676B1 (en)
CA (1) CA2358560C (en)
DE (1) DE69920756T2 (en)
DK (1) DK1144367T3 (en)
ES (1) ES2228154T3 (en)
PT (1) PT1144367E (en)
SI (1) SI1144367T1 (en)
WO (1) WO2000040547A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
OA12514A (en) 1999-12-24 2006-05-29 Aventis Pharma Ltd Azaindoles.
GB0115109D0 (en) 2001-06-21 2001-08-15 Aventis Pharma Ltd Chemical compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3719667A (en) 1970-08-24 1973-03-06 Lilly Co Eli Epimerization of 6-acylamido and 6-imido penicillin sulfoxide esters
US3840556A (en) 1971-05-28 1974-10-08 Lilly Co Eli Penicillin conversion by halogen electrophiles and anti-bacterials derived thereby
GB9421208D0 (en) * 1994-10-20 1994-12-07 Oxford Asymmetry Ltd Improvements in or relating to stereoselective syntheses

Also Published As

Publication number Publication date
DE69920756T2 (en) 2005-10-13
EP1144367B1 (en) 2004-09-29
WO2000040547A8 (en) 2001-09-13
CA2358560C (en) 2010-02-02
EP1144367A1 (en) 2001-10-17
KR20010092769A (en) 2001-10-26
WO2000040547B1 (en) 2000-10-19
BR9916676B1 (en) 2010-10-05
KR100657780B1 (en) 2006-12-15
BR9916676A (en) 2004-02-25
CN1173938C (en) 2004-11-03
US6433209B1 (en) 2002-08-13
ES2228154T3 (en) 2005-04-01
DE69920756D1 (en) 2004-11-04
DK1144367T3 (en) 2005-01-31
JP2003521464A (en) 2003-07-15
CA2358560A1 (en) 2000-07-13
ATE277896T1 (en) 2004-10-15
WO2000040547A1 (en) 2000-07-13
CN1334799A (en) 2002-02-06
SI1144367T1 (en) 2005-02-28
JP4771442B2 (en) 2011-09-14
PT1144367E (en) 2004-12-31

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase