SK282347B6 - Spôsob prípravy benzimidazolovej zlúčeniny - Google Patents

Spôsob prípravy benzimidazolovej zlúčeniny Download PDF

Info

Publication number
SK282347B6
SK282347B6 SK768-98A SK76898A SK282347B6 SK 282347 B6 SK282347 B6 SK 282347B6 SK 76898 A SK76898 A SK 76898A SK 282347 B6 SK282347 B6 SK 282347B6
Authority
SK
Slovakia
Prior art keywords
methoxy
pyridinyl
dimethyl
methyl
formula
Prior art date
Application number
SK768-98A
Other languages
English (en)
Slovak (sk)
Other versions
SK76898A3 (en
Inventor
Anders Gustavsson
�Ke K�Llstr�M
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of SK76898A3 publication Critical patent/SK76898A3/sk
Publication of SK282347B6 publication Critical patent/SK282347B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SK768-98A 1995-12-15 1996-12-05 Spôsob prípravy benzimidazolovej zlúčeniny SK282347B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9504503A SE521100C2 (sv) 1995-12-15 1995-12-15 Förfarande för framställning av en bensimidazolförening
PCT/SE1996/001603 WO1997022603A1 (en) 1995-12-15 1996-12-05 Method for the synthesis of a benzimidazole compound

Publications (2)

Publication Number Publication Date
SK76898A3 SK76898A3 (en) 1998-12-02
SK282347B6 true SK282347B6 (sk) 2002-01-07

Family

ID=20400614

Family Applications (1)

Application Number Title Priority Date Filing Date
SK768-98A SK282347B6 (sk) 1995-12-15 1996-12-05 Spôsob prípravy benzimidazolovej zlúčeniny

Country Status (40)

Country Link
US (1) US5958955A (es)
EP (1) EP0868423B1 (es)
JP (1) JP3523267B2 (es)
KR (1) KR100433436B1 (es)
CN (1) CN1113879C (es)
AR (1) AR004834A1 (es)
AT (1) ATE205201T1 (es)
AU (1) AU704422B2 (es)
CA (1) CA2238864C (es)
CO (1) CO4750654A1 (es)
CZ (1) CZ288661B6 (es)
DE (2) DE868423T1 (es)
DK (1) DK0868423T3 (es)
DZ (1) DZ2137A1 (es)
EE (1) EE03768B1 (es)
EG (1) EG23859A (es)
ES (1) ES2125210T3 (es)
HK (1) HK1010539A1 (es)
HR (1) HRP960581B1 (es)
HU (1) HUP9900110A3 (es)
IL (1) IL124856A (es)
IS (1) IS1891B (es)
MA (1) MA24026A1 (es)
MX (1) MX9804603A (es)
MY (1) MY115661A (es)
NO (1) NO314306B1 (es)
NZ (1) NZ324482A (es)
PL (1) PL186132B1 (es)
PT (1) PT868423E (es)
RU (1) RU2166502C2 (es)
SE (1) SE521100C2 (es)
SI (1) SI0868423T1 (es)
SK (1) SK282347B6 (es)
TN (1) TNSN96148A1 (es)
TR (1) TR199801070T2 (es)
TW (1) TW460474B (es)
UA (1) UA62921C2 (es)
WO (1) WO1997022603A1 (es)
YU (1) YU49420B (es)
ZA (1) ZA9610067B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE521100C2 (sv) * 1995-12-15 2003-09-30 Astra Ab Förfarande för framställning av en bensimidazolförening
US6489346B1 (en) 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6699885B2 (en) 1996-01-04 2004-03-02 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and methods of using same
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6645988B2 (en) * 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
SK283805B6 (sk) 1996-09-09 2004-02-03 Slovakofarma, A. S. Spôsob prípravy omeprazolu
US6303787B1 (en) * 1998-05-27 2001-10-16 Natco Pharma Limited Intermediates and an improved process for the preparation of Omeprazole employing the said intermediates
SI20019A (sl) * 1998-07-13 2000-02-29 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Izboljšan postopek sinteze 5-metoksi -2-/(4-metoksi-3,5-dimetil-2-piridil)metil/ sulfinil-1H-benzimidazola
US6166213A (en) * 1998-08-11 2000-12-26 Merck & Co., Inc. Omeprazole process and compositions thereof
UA72748C2 (en) 1998-11-10 2005-04-15 Astrazeneca Ab A novel crystalline form of omeprazole
IL142703A (en) 1998-11-10 2006-04-10 Astrazeneca Ab Crystalline form of omeprazole
DE19951960C2 (de) 1999-10-28 2002-06-27 Gruenenthal Gmbh Verfahren zur Herstellung als Ulkustherapeutika geeigneter Benzimidazol-Derivate
MXPA04007169A (es) * 2002-01-25 2004-10-29 Santarus Inc Suministro transmucosal de inhibidores de bomba de protones.
SE0203092D0 (en) 2002-10-18 2002-10-18 Astrazeneca Ab Method for the synthesis of a benzimidazole compound
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8815916B2 (en) 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
DE112005003147T5 (de) * 2004-12-16 2008-01-17 Cipla Ltd. Verfahren
CN100393712C (zh) * 2006-01-23 2008-06-11 中国科学院成都有机化学有限公司 苯并咪唑型质子泵抑止剂及其前体的改进制备和分离纯化方法
WO2007122686A1 (ja) * 2006-04-14 2007-11-01 Eisai R & D Management Co., Ltd. ベンズイミダゾール化合物
CA2678702A1 (en) * 2007-02-21 2008-08-28 Cipla Limited Process for the preparation of esomeprazole magnesium dihydrate
CN101492459B (zh) * 2008-01-25 2011-04-27 山东轩竹医药科技有限公司 含烷氧乙酰基二氢异噁唑并吡啶化合物
CN101497603B (zh) * 2008-01-30 2012-11-07 山东轩竹医药科技有限公司 含有被烷氧烷胺氧基取代的吡啶的苯并咪唑衍生物
CN103664885A (zh) * 2013-12-12 2014-03-26 武汉工程大学 苯并咪唑型质子泵抑制剂中间体的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US461997A (en) * 1891-10-27 Sand-pump or other pipes
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
JPS6150978A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
US4619997A (en) * 1984-09-06 1986-10-28 The Upjohn Company Substituted 2-pyridylmethylthio and sulfinyl-benzimidazoles as gastric antisecretory agents
IL76839A (en) * 1984-10-31 1988-08-31 Byk Gulden Lomberg Chem Fab Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
SE9002043D0 (sv) * 1990-06-07 1990-06-07 Astra Ab Improved method for synthesis
NZ244301A (en) * 1991-09-20 1994-08-26 Merck & Co Inc Preparation of 2-pyridylmethylsulphinylbenzimidazole and pyridoimidazole derivatives from the corresponding sulphenyl compounds
SE521100C2 (sv) * 1995-12-15 2003-09-30 Astra Ab Förfarande för framställning av en bensimidazolförening

Also Published As

Publication number Publication date
HUP9900110A2 (hu) 2000-03-28
KR100433436B1 (ko) 2004-07-16
CZ168598A3 (cs) 1998-09-16
JP2000502101A (ja) 2000-02-22
IL124856A (en) 2002-12-01
EP0868423B1 (en) 2001-09-05
DE69615052T2 (de) 2002-06-27
IL124856A0 (en) 1999-01-26
US5958955A (en) 1999-09-28
HUP9900110A3 (en) 2002-10-28
HRP960581A2 (en) 1998-02-28
EG23859A (en) 2007-11-18
DZ2137A1 (fr) 2002-10-23
SI0868423T1 (en) 2002-04-30
CA2238864C (en) 2006-01-24
NO314306B1 (no) 2003-03-03
UA62921C2 (en) 2004-01-15
AR004834A1 (es) 1999-03-10
CA2238864A1 (en) 1997-06-26
ATE205201T1 (de) 2001-09-15
DK0868423T3 (da) 2001-12-03
MX9804603A (es) 1998-10-31
PL327334A1 (en) 1998-12-07
CO4750654A1 (es) 1999-03-31
MA24026A1 (fr) 1997-07-01
SE521100C2 (sv) 2003-09-30
RU2166502C2 (ru) 2001-05-10
ES2125210T3 (es) 2002-02-01
CN1204332A (zh) 1999-01-06
SE9504503D0 (sv) 1995-12-15
MY115661A (en) 2003-08-30
YU64296A (sh) 1999-07-28
NO982624D0 (no) 1998-06-08
PL186132B1 (pl) 2003-10-31
CN1113879C (zh) 2003-07-09
TNSN96148A1 (fr) 2005-03-15
WO1997022603A1 (en) 1997-06-26
AU1155097A (en) 1997-07-14
JP3523267B2 (ja) 2004-04-26
AU704422B2 (en) 1999-04-22
EP0868423A1 (en) 1998-10-07
TW460474B (en) 2001-10-21
NZ324482A (en) 2000-04-28
HK1010539A1 (en) 1999-06-25
DE69615052D1 (de) 2001-10-11
PT868423E (pt) 2002-02-28
IS1891B (is) 2003-09-19
KR20000064399A (ko) 2000-11-06
HRP960581B1 (en) 2001-12-31
TR199801070T2 (xx) 1998-08-21
EE9800183A (et) 1998-12-15
ES2125210T1 (es) 1999-03-01
DE868423T1 (de) 1999-06-02
NO982624L (no) 1998-06-08
EE03768B1 (et) 2002-06-17
YU49420B (sh) 2006-01-16
SK76898A3 (en) 1998-12-02
ZA9610067B (en) 1997-06-17
IS4750A (is) 1998-05-22
SE9504503L (sv) 1997-06-16
CZ288661B6 (cs) 2001-08-15

Similar Documents

Publication Publication Date Title
SK282347B6 (sk) Spôsob prípravy benzimidazolovej zlúčeniny
JP2993122B2 (ja) オメプラゾールの合成法
RU98110659A (ru) Способ синтеза соединений бензимидазола
CA2405304C (en) Method for obtaining derivatives of [[(pyridil substituted)methyl]thio]benzimidazole
EP1575935B1 (en) Process for the preparation of sulphinyl derivatives by oxidation of the corresponding sulfides
EP1095037B1 (en) process of synthesis of 5-methoxy- 2- (4-methoxy- 3,5-dimethyl- 2-pyridyl)methyl]sulfinyl-1h-benzimidazole
AU2006242782B2 (en) New process for synthesis of proton pump inhibitors
WO2009116072A2 (en) Process for preparation of pyridinylmethylsulphinyl benzimidazole compounds and pyridine intermediates
US7557218B2 (en) Hydrates of optionally substituted 2-(2-pyridinyl) methylthio-1H-benzimidazoles and process for the production thereof
EP2022789A1 (en) Process for the preparation of a gastric acid secretion inhibitor
EP1485373A1 (en) Method of stabilizing lansoprazole
WO2004046135A1 (en) Stable lansoprazole containing more than 500 ppm, up to about 3,000 ppm water and more than 200 ppm, up to about 5,000 ppm alcohol
WO2006049486A1 (en) A PREPARATION METHOD FOR SUBSTITUTED 2-(2-PYRIDYLMETHOYLSULPHINYL)-l-H-BENZIMID AZOLES
AU780944B2 (en) Method for producing therapeutic agents for ulcers
WO2008087665A2 (en) Process for preparation of lansoprazole
EP1085019A1 (en) Omeprazole synthesis
SA96170440B1 (ar) benzimidazoleعملية لتخلق مركب بنزيميدازول

Legal Events

Date Code Title Description
MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20091205