SK278900B6 - 2-substituovaný alkyl-3-karboxykarbapenémové zlúče - Google Patents

2-substituovaný alkyl-3-karboxykarbapenémové zlúče Download PDF

Info

Publication number
SK278900B6
SK278900B6 SK929-91A SK92991A SK278900B6 SK 278900 B6 SK278900 B6 SK 278900B6 SK 92991 A SK92991 A SK 92991A SK 278900 B6 SK278900 B6 SK 278900B6
Authority
SK
Slovakia
Prior art keywords
oxo
group
methyl
ethyl
phenyl
Prior art date
Application number
SK929-91A
Other languages
English (en)
Slovak (sk)
Inventor
Carl B. Ziegler
William V. Curran
Gregg Feigelson
Original Assignee
American Cyanamid Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Company filed Critical American Cyanamid Company
Publication of SK278900B6 publication Critical patent/SK278900B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SK929-91A 1990-04-10 1991-04-04 2-substituovaný alkyl-3-karboxykarbapenémové zlúče SK278900B6 (sk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/507,271 US5068232A (en) 1990-04-10 1990-04-10 Novel 2-substituted alkyl-3-carboxy carbapenems as antibiotics and a method of producing them

Publications (1)

Publication Number Publication Date
SK278900B6 true SK278900B6 (sk) 1998-04-08

Family

ID=24017956

Family Applications (1)

Application Number Title Priority Date Filing Date
SK929-91A SK278900B6 (sk) 1990-04-10 1991-04-04 2-substituovaný alkyl-3-karboxykarbapenémové zlúče

Country Status (20)

Country Link
US (3) US5068232A (cs)
EP (1) EP0478874A3 (cs)
JP (1) JPH04234885A (cs)
KR (1) KR0183020B1 (cs)
CN (3) CN1034332C (cs)
AU (1) AU634876B2 (cs)
CA (1) CA2039968A1 (cs)
CZ (1) CZ280808B6 (cs)
FI (1) FI95256C (cs)
HU (1) HU215606B (cs)
IE (1) IE910676A1 (cs)
IL (1) IL97275A (cs)
NO (1) NO178624C (cs)
NZ (1) NZ237610A (cs)
PH (1) PH27462A (cs)
PL (3) PL165937B1 (cs)
PT (1) PT97301B (cs)
SK (1) SK278900B6 (cs)
TW (1) TW229209B (cs)
ZA (1) ZA912629B (cs)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9104838D0 (en) * 1991-03-07 1991-04-17 Glaxo Spa Heterocyclic compounds
US5189158A (en) * 1991-03-20 1993-02-23 American Cyanamid Company 4-substituted azetidinones as precursors to 2-substituted-3-carboxy carbapenem antibiotics and a method of producing them
EP0695753A1 (en) * 1994-08-05 1996-02-07 Zeneca Limited Carbapenem derivatives containing a bicyclic substituent, process for their preparation, and their use
US5607928A (en) * 1994-08-05 1997-03-04 Zeneca Limited Carbapenem derivatives containing a bicyclic ketone substituent and their use as anti-infectives
JP4212112B2 (ja) 1996-02-23 2009-01-21 イーライ・リリー・アンド・カンパニー 非ペプチジルバソプレッシンＶ１ａアンタゴニスト
WO2002066984A2 (en) * 2001-02-16 2002-08-29 Pepscan Systems B.V. Arrays for determining binding of biomolecules
US7632828B2 (en) * 2004-06-10 2009-12-15 Fob Synthesis, Inc. Gram-positive carbapenem antibacterials and processes for their preparation
US20090018111A1 (en) * 2004-10-08 2009-01-15 Makoto Sunagawa Novel Antimicrobial Medicament
CN105906537B (zh) * 2016-04-27 2017-12-15 湖南科技学院 （z）式磺酰基烯酸酯化合物的一锅合成方法
CN105884663B (zh) * 2016-04-27 2017-12-15 湖南科技学院 一种(z)‑磺酰基烯酸酯的制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56122379A (en) * 1980-03-03 1981-09-25 Sankyo Co Ltd 1-carba-2-penem-3-carboxylic acid derivative
US4350631A (en) * 1980-12-18 1982-09-21 Merck & Co., Inc. 6- and 4-Substituted-1-azabicyclo[3.2.0]heptan-3,7-dione-2-carboxylates
CA1179675A (en) * 1981-01-30 1984-12-18 Erwin Gotschi 7-oxo-1-azabicyclo ¬3,2,0| heptene-2-derivatives
JPS58103388A (ja) * 1981-12-11 1983-06-20 Sankyo Co Ltd カルバペネム誘導体
EP0171064B1 (en) * 1984-08-06 1995-07-12 Fujisawa Pharmaceutical Co., Ltd. Azetidinone derivative and processes for production thereof
EP0184844A1 (en) * 1984-12-13 1986-06-18 Merck & Co. Inc. 1-Methylcarbapenems having a 2-position substituent joined through an alkylenethio bridge
US4882429A (en) * 1986-03-03 1989-11-21 Schering Corporation Stereospecific preparation of (3S,4R,5R)-3-(1-hydroxyethyl)-4-benzoyloxy-azeridinones from L-(-)-theonine
IT1197873B (it) * 1986-10-15 1988-12-21 Erba Farmitalia Procedimento per la preparazione di azetidinoni
US5021565A (en) * 1986-10-16 1991-06-04 Merck & Co., Inc. Novel 2-substituted alkyl carbapenem antibacterials
DE3779856T2 (de) * 1986-10-16 1993-03-25 Merck & Co Inc Antibakterielle, 2-substituierte alkyl-carbapeneme.
JPS63218659A (ja) * 1987-03-06 1988-09-12 Yasumitsu Tamura β−ラクタム化合物およびその製造法
JPH0193586A (ja) * 1987-10-05 1989-04-12 Yasumitsu Tamura カルバベネム化合物およびその製造法
US4960879A (en) * 1988-03-23 1990-10-02 Shionogi & Co., Ltd. Process for carbapenem intermediates
JPH0642853Y2 (ja) * 1988-10-28 1994-11-09 新王子製紙株式会社 プリンター
JPH03120280A (ja) * 1989-10-03 1991-05-22 Shionogi & Co Ltd ハロメチルカルバペネム化合物の製法

Also Published As

Publication number Publication date
PL165952B1 (pl) 1995-03-31
CA2039968A1 (en) 1991-10-11
KR0183020B1 (ko) 1999-05-01
EP0478874A2 (en) 1992-04-08
NZ237610A (en) 1995-02-24
HU215606B (hu) 1999-01-28
NO178624C (no) 1996-05-02
CN1034329C (zh) 1997-03-26
EP0478874A3 (en) 1993-03-24
FI911701A (fi) 1991-10-11
PT97301A (pt) 1992-01-31
CS92991A3 (en) 1992-04-15
FI95256C (fi) 1996-01-10
CZ280808B6 (cs) 1996-04-17
AU7424891A (en) 1991-10-17
NO911368L (no) 1991-10-11
US5480987A (en) 1996-01-02
KR910018384A (ko) 1991-11-30
PL166336B1 (pl) 1995-05-31
US5369102A (en) 1994-11-29
FI95256B (fi) 1995-09-29
IL97275A0 (en) 1992-05-25
CN1108648A (zh) 1995-09-20
PL165937B1 (pl) 1995-03-31
PT97301B (pt) 1998-08-31
HU911141D0 (en) 1991-10-28
JPH04234885A (ja) 1992-08-24
IL97275A (en) 1996-01-31
NO178624B (no) 1996-01-22
US5068232A (en) 1991-11-26
FI911701A0 (fi) 1991-04-09
PL294071A1 (cs) 1993-02-08
CN1108649A (zh) 1995-09-20
PL289814A1 (en) 1992-08-10
AU634876B2 (en) 1993-03-04
CN1037177C (zh) 1998-01-28
ZA912629B (en) 1992-01-29
PH27462A (en) 1993-07-09
NO911368D0 (no) 1991-04-09
CN1056878A (zh) 1991-12-11
TW229209B (cs) 1994-09-01
IE910676A1 (en) 1991-10-23
HUT57770A (en) 1991-12-30
CN1034332C (zh) 1997-03-26

Similar Documents

Publication Publication Date Title
EP0070204B1 (en) Carboxylic beta-lactam compounds and the preparation thereof
US4485110A (en) β-Lactam compounds, and use
SK278688B6 (sk) Kyselina 10-(1-hydroxyetyl)-11-oxo-1-azatricyklo[7
SK278900B6 (sk) 2-substituovaný alkyl-3-karboxykarbapenémové zlúče
EP0336143A1 (en) A new process for carbapenem intermediates
US5096899A (en) Oxapenem-3-carboxylic acids
EP0008514A1 (en) Beta-lactam anti-bacterials, compositions containing them and a process for their preparation
EP0080162A1 (en) 2-(Fluoroalkylthio)substituted penems, processes for preparing them, and pharmaceutical compositions containing them
US4772683A (en) High percentage beta-yield synthesis of carbapenem intermediates
HUT67125A (en) Tricyclyc carbapeneme derivatives, pharmaceutical compositions containing them and process for their preparation
EP0060077A1 (en) Beta-lactam antibiotics, their preparation and use
KR880001989B1 (ko) 펜엠 화합물의 제조방법
EP0170019A1 (de) Carbapeneme mit Aethergruppe in 4-Stellung
SK278789B6 (sk) 4-substituované azetidinóny a spôsob ich výroby
US4895939A (en) High percentage β-yield synthesis of carbapenem intermediates
FI100328B (fi) Uusia 4-allyyli-2-okso-1-atsetidiinietikkahappojohdannaisia
FI100327B (fi) Uusia 4-propargyyli-2-okso-1-atsetidiinietikkahappojohdannaisia
JP2689412B2 (ja) 保護基の除去方法
JPH0670059B2 (ja) フルオロアルキル化カルバペネム中間体
US4760058A (en) Penam derivatives
PT94589A (pt) Processo para a preparacao de antibioticos 2-metoximetil-penemicos e de composicoes farmaceuticas que os contem
JP2002338572A (ja) カルバペネム類の製造法
NZ260177A (en) Azetidinone acetic acid derivatives; preparation of propynyl azetidinone derivatives
JP2004107289A (ja) ビニルスルフィド化合物の製造法
IE871080L (en) Preparing 2-thiacephems