SK176197A3 - A vaccine composition comprising a polysaccharide conjugate antigen adsorbed onto aluminium phosphate - Google Patents
A vaccine composition comprising a polysaccharide conjugate antigen adsorbed onto aluminium phosphate Download PDFInfo
- Publication number
- SK176197A3 SK176197A3 SK1761-97A SK176197A SK176197A3 SK 176197 A3 SK176197 A3 SK 176197A3 SK 176197 A SK176197 A SK 176197A SK 176197 A3 SK176197 A3 SK 176197A3
- Authority
- SK
- Slovakia
- Prior art keywords
- vaccine
- carrier
- polysaccharide
- conjugate
- protein
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title claims abstract description 45
- 239000000427 antigen Substances 0.000 title claims abstract description 22
- 102000036639 antigens Human genes 0.000 title claims abstract description 22
- 108091007433 antigens Proteins 0.000 title claims abstract description 22
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 title claims abstract description 16
- 239000000203 mixture Substances 0.000 title claims abstract description 13
- 150000004676 glycans Chemical class 0.000 title claims description 33
- 229920001282 polysaccharide Polymers 0.000 title claims description 33
- 239000005017 polysaccharide Substances 0.000 title claims description 33
- 229910000147 aluminium phosphate Inorganic materials 0.000 title abstract description 3
- 229940001007 aluminium phosphate Drugs 0.000 title abstract 2
- 241000606768 Haemophilus influenzae Species 0.000 claims abstract description 13
- 208000015181 infectious disease Diseases 0.000 claims abstract description 6
- 238000004519 manufacturing process Methods 0.000 claims abstract description 5
- 239000003814 drug Substances 0.000 claims abstract description 3
- 102000004169 proteins and genes Human genes 0.000 claims description 11
- 108090000623 proteins and genes Proteins 0.000 claims description 11
- 229960000814 tetanus toxoid Drugs 0.000 claims description 11
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- 206010013023 diphtheria Diseases 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 10
- 206010043376 Tetanus Diseases 0.000 claims description 9
- 229940047650 haemophilus influenzae Drugs 0.000 claims description 9
- 102000014914 Carrier Proteins Human genes 0.000 claims description 6
- 108010078791 Carrier Proteins Proteins 0.000 claims description 6
- 201000005702 Pertussis Diseases 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 241000709721 Hepatovirus A Species 0.000 claims description 5
- 208000002672 hepatitis B Diseases 0.000 claims description 5
- 238000001179 sorption measurement Methods 0.000 claims description 5
- 208000000474 Poliomyelitis Diseases 0.000 claims description 4
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- 101710116435 Outer membrane protein Proteins 0.000 claims description 3
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- 238000009472 formulation Methods 0.000 abstract description 5
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- 230000002265 prevention Effects 0.000 abstract description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 9
- 238000010168 coupling process Methods 0.000 description 7
- 238000005859 coupling reaction Methods 0.000 description 7
- 241000700159 Rattus Species 0.000 description 6
- 230000008878 coupling Effects 0.000 description 6
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- 239000011780 sodium chloride Substances 0.000 description 5
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- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 230000021615 conjugation Effects 0.000 description 3
- ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000003053 immunization Effects 0.000 description 3
- 238000002649 immunization Methods 0.000 description 3
- 230000004224 protection Effects 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- AZUYLZMQTIKGSC-UHFFFAOYSA-N 1-[6-[4-(5-chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methylindazol-5-yl)pyrazol-1-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one Chemical compound ClC=1C(=C2C=NNC2=CC=1C)C=1C(=NN(C=1C)C1CC2(CN(C2)C(C=C)=O)C1)C=1C=C2C=NN(C2=CC=1)C AZUYLZMQTIKGSC-UHFFFAOYSA-N 0.000 description 2
- -1 1-cyano-4-dimethylamino pyridinium tetrafluoroborate Chemical compound 0.000 description 2
- ALEBYBVYXQTORU-UHFFFAOYSA-N 6-hydrazinyl-6-oxohexanoic acid Chemical compound NNC(=O)CCCCC(O)=O ALEBYBVYXQTORU-UHFFFAOYSA-N 0.000 description 2
- 241000588832 Bordetella pertussis Species 0.000 description 2
- 108010060123 Conjugate Vaccines Proteins 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
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- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 241000588650 Neisseria meningitidis Species 0.000 description 2
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 150000001718 carbodiimides Chemical class 0.000 description 2
- 229940031670 conjugate vaccine Drugs 0.000 description 2
- 239000004643 cyanate ester Substances 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
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- 208000005252 hepatitis A Diseases 0.000 description 2
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- 239000008101 lactose Substances 0.000 description 2
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- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
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- 241000894006 Bacteria Species 0.000 description 1
- HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
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- 229910019142 PO4 Inorganic materials 0.000 description 1
- 229940124909 PedvaxHIB Drugs 0.000 description 1
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- 101710137302 Surface antigen S Proteins 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
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- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
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- SPSXSWRZQFPVTJ-ZQQKUFEYSA-N hepatitis b vaccine Chemical compound C([C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCSC)C(=O)N[C@@H](CC1N=CN=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)OC(=O)CNC(=O)CNC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](N)CCCNC(N)=N)C1=CC=CC=C1 SPSXSWRZQFPVTJ-ZQQKUFEYSA-N 0.000 description 1
- SYECJBOWSGTPLU-UHFFFAOYSA-N hexane-1,1-diamine Chemical compound CCCCCC(N)N SYECJBOWSGTPLU-UHFFFAOYSA-N 0.000 description 1
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- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
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- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
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- HEBKCHPVOIAQTA-ZXFHETKHSA-N ribitol Chemical compound OC[C@H](O)[C@H](O)[C@H](O)CO HEBKCHPVOIAQTA-ZXFHETKHSA-N 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
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- 150000003568 thioethers Chemical class 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9512827.8A GB9512827D0 (en) | 1995-06-23 | 1995-06-23 | Vaccines |
| GBGB9513443.3A GB9513443D0 (en) | 1995-07-01 | 1995-07-01 | Vaccines |
| GBGB9525657.4A GB9525657D0 (en) | 1995-12-15 | 1995-12-15 | Vaccines |
| GBGB9606032.2A GB9606032D0 (en) | 1996-03-22 | 1996-03-22 | Vaccines |
| PCT/EP1996/002690 WO1997000697A1 (en) | 1995-06-23 | 1996-06-19 | A vaccine composition comprising a polysaccharide conjugate antigen adsorbed onto aluminium phosphate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK176197A3 true SK176197A3 (en) | 1998-07-08 |
Family
ID=27451299
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1761-97A SK176197A3 (en) | 1995-06-23 | 1996-06-19 | A vaccine composition comprising a polysaccharide conjugate antigen adsorbed onto aluminium phosphate |
Country Status (36)
| Country | Link |
|---|---|
| EP (2) | EP1082965B1 (es) |
| JP (2) | JP4850987B2 (es) |
| KR (1) | KR100425929B1 (es) |
| CN (1) | CN1146444C (es) |
| AP (1) | AP812A (es) |
| AR (1) | AR003006A1 (es) |
| AT (2) | ATE199831T1 (es) |
| AU (1) | AU696338B2 (es) |
| BG (1) | BG62720B1 (es) |
| BR (1) | BRPI9609414B8 (es) |
| CA (1) | CA2222455C (es) |
| CY (1) | CY2297B1 (es) |
| CZ (1) | CZ288908B6 (es) |
| DE (2) | DE69637950D1 (es) |
| DK (2) | DK0833662T4 (es) |
| DZ (1) | DZ2055A1 (es) |
| EA (1) | EA199700413A1 (es) |
| EG (1) | EG25924A (es) |
| ES (2) | ES2157447T5 (es) |
| GR (1) | GR3036088T3 (es) |
| HK (2) | HK1037516A1 (es) |
| HU (1) | HU224514B1 (es) |
| IL (1) | IL122588A (es) |
| MA (1) | MA23918A1 (es) |
| MY (1) | MY114786A (es) |
| NO (1) | NO325169B1 (es) |
| NZ (1) | NZ312132A (es) |
| OA (1) | OA10646A (es) |
| PE (1) | PE11298A1 (es) |
| PL (1) | PL184872B1 (es) |
| PT (2) | PT833662E (es) |
| SI (2) | SI1082965T1 (es) |
| SK (1) | SK176197A3 (es) |
| TR (1) | TR199701682T1 (es) |
| TW (1) | TW467746B (es) |
| WO (1) | WO1997000697A1 (es) |
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| PT835663E (pt) | 1992-05-23 | 2010-01-04 | Glaxosmithkline Biolog Sa | Vacinas combinadas compreendendo o antigénio de superfície da hepatite b e outros antigénios |
| US6355450B1 (en) | 1995-04-21 | 2002-03-12 | Human Genome Sciences, Inc. | Computer readable genomic sequence of Haemophilus influenzae Rd, fragments thereof, and uses thereof |
| US6468765B1 (en) | 1995-04-21 | 2002-10-22 | Human Genome Sciences, Inc. | Selected Haemophilus influenzae Rd polynucleotides and polypeptides |
| US6696065B1 (en) | 1995-05-04 | 2004-02-24 | Aventis Pastuer Limited | Acellular pertussis vaccines and methods of preparation thereof |
| SK176197A3 (en) * | 1995-06-23 | 1998-07-08 | Smithkline Beecham Biolog | A vaccine composition comprising a polysaccharide conjugate antigen adsorbed onto aluminium phosphate |
| RU2194531C2 (ru) * | 1996-07-02 | 2002-12-20 | Коннот Лабораториз Лимитед | Поливалентные ассоциированные коклюшно-дифтерийно-столбнячно (акдс)-полиомиелитные вакцины |
| GB9806456D0 (en) * | 1998-03-25 | 1998-05-27 | Smithkline Beecham Biolog | Vaccine composition |
| CA2773698C (en) | 1998-10-16 | 2015-05-19 | Glaxosmithkline Biologicals S.A. | Adjuvant systems comprising an immunostimulant adsorbed to a metallic salt particle and vaccines thereof |
| US6585973B1 (en) | 1998-10-29 | 2003-07-01 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Method for preparing solid phase conjugated vaccine |
| GB9928196D0 (en) | 1999-11-29 | 2000-01-26 | Chiron Spa | Combinations of B, C and other antigens |
| AP1695A (en) * | 2000-06-29 | 2006-12-17 | Glaxosmithkline Biologicals Sa | Multivalent vaccine composition. |
| GB0108364D0 (en) * | 2001-04-03 | 2001-05-23 | Glaxosmithkline Biolog Sa | Vaccine composition |
| RO122761B1 (ro) | 2001-01-23 | 2010-01-29 | Aventis Pasteur | Vaccin multivalent antimeningococic conţinând polizaharid-proteină |
| GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| GB0118249D0 (en) | 2001-07-26 | 2001-09-19 | Chiron Spa | Histidine vaccines |
| CA2501812C (en) | 2002-10-11 | 2012-07-10 | Mariagrazia Pizza | Polypeptide-vaccines for broad protection against hypervirulent meningococcal lineages |
| DK2395073T3 (en) * | 2002-11-01 | 2017-10-23 | Glaxosmithkline Biologicals Sa | Process for drying. |
| GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
| ES2411080T3 (es) | 2003-01-30 | 2013-07-04 | Novartis Ag | Vacunas inyectables contra múltiples serogrupos de meningococos |
| GB0313916D0 (en) | 2003-06-16 | 2003-07-23 | Glaxosmithkline Biolog Sa | Vaccine composition |
| GB0323103D0 (en) | 2003-10-02 | 2003-11-05 | Chiron Srl | De-acetylated saccharides |
| RU2378010C2 (ru) | 2003-10-02 | 2010-01-10 | Новартис Вэксинес Энд Дайэгностикс С.Р.Л. | Жидкие вакцины для множественных серогрупп менингококков |
| WO2005032584A2 (en) * | 2003-10-02 | 2005-04-14 | Glaxosmithkline Biologicals S.A. | Pertussis antigens and use thereof in vaccination |
| GB0405787D0 (en) * | 2004-03-15 | 2004-04-21 | Chiron Srl | Low dose vaccines |
| GB0409745D0 (en) | 2004-04-30 | 2004-06-09 | Chiron Srl | Compositions including unconjugated carrier proteins |
| GB0500787D0 (en) | 2005-01-14 | 2005-02-23 | Chiron Srl | Integration of meningococcal conjugate vaccination |
| BRPI0510315A (pt) | 2004-04-30 | 2007-10-16 | Chiron Srl | integração de vacinação com conjugado meningocócico |
| GB0505518D0 (en) | 2005-03-17 | 2005-04-27 | Chiron Srl | Combination vaccines with whole cell pertussis antigen |
| GB0505996D0 (en) | 2005-03-23 | 2005-04-27 | Glaxosmithkline Biolog Sa | Fermentation process |
| WO2006113528A2 (en) | 2005-04-18 | 2006-10-26 | Novartis Vaccines And Diagnostics Inc. | Expressing hepatitis b virus surface antigen for vaccine preparation |
| PT2351578T (pt) | 2005-06-27 | 2017-04-07 | Glaxosmithkline Biologicals Sa | Processo para o fabrico de vacinas |
| GB0522765D0 (en) | 2005-11-08 | 2005-12-14 | Chiron Srl | Combination vaccine manufacture |
| GB0524066D0 (en) | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
| US10828361B2 (en) | 2006-03-22 | 2020-11-10 | Glaxosmithkline Biologicals Sa | Regimens for immunisation with meningococcal conjugates |
| SI2004225T1 (sl) | 2006-03-22 | 2012-08-31 | Novartis Ag | Reĺ˝imi za imunizacijo z meningokoknimi konjugati |
| MX2009002560A (es) | 2006-09-07 | 2009-03-20 | Glaxosmithkline Biolog Sa | Vacuna. |
| EA201490303A1 (ru) | 2007-05-02 | 2014-05-30 | Глаксосмитклайн Байолоджикалс С.А. | Вакцина |
| US20100203137A1 (en) | 2007-06-04 | 2010-08-12 | Mario Contorni | Formulation of meningitis vaccines |
| FR2918671B1 (fr) | 2007-07-10 | 2010-10-15 | Sanofi Pasteur | Milieu de culture d'haemophilus influenzae type b. |
| GB0818453D0 (en) | 2008-10-08 | 2008-11-12 | Novartis Ag | Fermentation processes for cultivating streptococci and purification processes for obtaining cps therefrom |
| GB0822633D0 (en) | 2008-12-11 | 2009-01-21 | Novartis Ag | Formulation |
| TW201043267A (en) * | 2009-03-19 | 2010-12-16 | Intervet Int Bv | In situ constituting a vaccine for administration to a predetermined herd of animals |
| WO2010109323A1 (en) * | 2009-03-24 | 2010-09-30 | Novartis Ag | Adjuvanting meningococcal factor h binding protein |
| IT1398927B1 (it) | 2009-06-25 | 2013-03-28 | Consorzio Interuniversitario Per Lo Sviluppo Dei Sistemi A Grande Interfase Csgi | Espressione batterica di un gene artificiale per la produzione di crm197 e derivati. |
| GB0917647D0 (en) | 2009-10-08 | 2009-11-25 | Glaxosmithkline Biolog Sa | Expression system |
| EP3459562B1 (en) | 2011-01-05 | 2024-03-20 | Bharat Biotech International Limited | A combination heptavalent vaccine |
| GB201105981D0 (en) | 2011-04-08 | 2011-05-18 | Glaxosmithkline Biolog Sa | Novel process |
| TW201302779A (zh) | 2011-04-13 | 2013-01-16 | Glaxosmithkline Biolog Sa | 融合蛋白質及組合疫苗 |
| EP2592137A1 (en) | 2011-11-11 | 2013-05-15 | Novartis AG | Fermentation media free of animal-derived components for production of diphtheria toxoids suitable for human vaccine use |
| GB2495341B (en) | 2011-11-11 | 2013-09-18 | Novartis Ag | Fermentation methods and their products |
| DE102011118371B4 (de) | 2011-11-11 | 2014-02-13 | Novartis Ag | Zur Impfung von Menschen geeignete Zusammensetzung, die ein Diphtherie-Toxoid umfasst, sowie Verfahren zu deren Herstellung |
| DE102011122891B4 (de) | 2011-11-11 | 2014-12-24 | Novartis Ag | Fermentationsmedium, das frei von tierischen Bestandteilen ist, zur Herstellung von Diphtherie-Toxoiden zur Verwendung bei der Impfung von Menschen |
| US9475848B2 (en) | 2012-02-01 | 2016-10-25 | Glaxosmithkline Biologicals S.A. | Fermentation process for producing a virulence factor from bordetella |
| WO2014009971A2 (en) * | 2012-07-07 | 2014-01-16 | Bharat Biotech International Limited | Non-alcoholic vaccine compositions free from animal- origin and process for preparation thereof |
| US20140037680A1 (en) | 2012-08-06 | 2014-02-06 | Glaxosmithkline Biologicals, S.A. | Novel method |
| AU2013301312A1 (en) | 2012-08-06 | 2015-03-19 | Glaxosmithkline Biologicals S.A. | Method for eliciting in infants an immune response against RSV and B. pertussis |
| EP3620172A1 (en) | 2012-10-12 | 2020-03-11 | GlaxoSmithKline Biologicals SA | Non-cross-linked acellular pertussis antigens for use in combination vaccines |
| KR20160040290A (ko) | 2013-08-05 | 2016-04-12 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 조합 면역원성 조성물 |
| WO2018156465A1 (en) * | 2017-02-24 | 2018-08-30 | Merck Sharp & Dohme Corp. | Polysaccharide-protein conjugates utilizing diphtheria toxin fragment b as a carrier |
| AU2018302767A1 (en) | 2017-07-18 | 2020-03-05 | Serum Institute Of India Pvt Ltd. | An immunogenic composition having improved stability, enhanced immunogenicity and reduced reactogenicity and process for preparation thereof |
| JOP20190242A1 (ar) | 2018-10-12 | 2020-04-12 | Serum Institute Of India Pvt Ltd | تركيبة لقاح توليفي تشمل فيروس شلل الأطفال ذو جرعة مخفّضة خاملة التنشيط وطريقة لتحضيرها |
| AU2020277403A1 (en) | 2019-05-20 | 2022-01-06 | Soligenix, Inc. | Compositions and methods of manufacturing trivalent filovirus vaccines |
| CN111658617A (zh) * | 2019-10-14 | 2020-09-15 | 四川大学 | 一种含铝佐剂疫苗的冻干制剂及其制备方法和用途 |
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| US4235877A (en) | 1979-06-27 | 1980-11-25 | Merck & Co., Inc. | Liposome particle containing viral or bacterial antigenic subunit |
| US4372945A (en) | 1979-11-13 | 1983-02-08 | Likhite Vilas V | Antigen compounds |
| IL61904A (en) | 1981-01-13 | 1985-07-31 | Yeda Res & Dev | Synthetic vaccine against influenza virus infections comprising a synthetic peptide and process for producing same |
| US4695624A (en) | 1984-05-10 | 1987-09-22 | Merck & Co., Inc. | Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency |
| EP0471177B1 (en) * | 1990-08-13 | 1995-10-04 | American Cyanamid Company | Filamentous hemagglutinin of bordetella pertussis as a carrier molecule for conjugate vaccines |
| US5153312A (en) | 1990-09-28 | 1992-10-06 | American Cyanamid Company | Oligosaccharide conjugate vaccines |
| NZ249704A (en) | 1992-02-11 | 1996-11-26 | Jackson H M Found Military Med | A two carrier immunogenic construct comprising a 70+ kd molecule conjugated to at least 1 t-dependent antigen, preparation, compositions containing the construct |
| PT835663E (pt) | 1992-05-23 | 2010-01-04 | Glaxosmithkline Biolog Sa | Vacinas combinadas compreendendo o antigénio de superfície da hepatite b e outros antigénios |
| ATE176157T1 (de) * | 1992-10-27 | 1999-02-15 | American Cyanamid Co | Pädiatrische kombinationsvakzine mit verbesserter immunogenizität jeder vakzine komponente |
| SK176197A3 (en) * | 1995-06-23 | 1998-07-08 | Smithkline Beecham Biolog | A vaccine composition comprising a polysaccharide conjugate antigen adsorbed onto aluminium phosphate |
-
1996
- 1996-06-19 SK SK1761-97A patent/SK176197A3/sk unknown
- 1996-06-19 EP EP00203874A patent/EP1082965B1/en not_active Expired - Lifetime
- 1996-06-19 PT PT96922871T patent/PT833662E/pt unknown
- 1996-06-19 CN CNB961949732A patent/CN1146444C/zh not_active Expired - Lifetime
- 1996-06-19 CZ CZ19974189A patent/CZ288908B6/cs not_active IP Right Cessation
- 1996-06-19 DE DE69637950T patent/DE69637950D1/de not_active Expired - Lifetime
- 1996-06-19 ES ES96922871T patent/ES2157447T5/es not_active Expired - Lifetime
- 1996-06-19 AT AT96922871T patent/ATE199831T1/de active
- 1996-06-19 IL IL12258896A patent/IL122588A/en not_active IP Right Cessation
- 1996-06-19 PT PT00203874T patent/PT1082965E/pt unknown
- 1996-06-19 SI SI9630768T patent/SI1082965T1/sl unknown
- 1996-06-19 WO PCT/EP1996/002690 patent/WO1997000697A1/en active IP Right Grant
- 1996-06-19 AU AU63591/96A patent/AU696338B2/en not_active Expired
- 1996-06-19 AT AT00203874T patent/ATE433329T1/de active
- 1996-06-19 AP APAP/P/1997/001159A patent/AP812A/en active
- 1996-06-19 DK DK96922871.7T patent/DK0833662T4/da active
- 1996-06-19 EP EP96922871A patent/EP0833662B2/en not_active Expired - Lifetime
- 1996-06-19 CA CA2222455A patent/CA2222455C/en not_active Expired - Lifetime
- 1996-06-19 NZ NZ312132A patent/NZ312132A/en not_active IP Right Cessation
- 1996-06-19 JP JP50358197A patent/JP4850987B2/ja not_active Expired - Lifetime
- 1996-06-19 TR TR97/01682T patent/TR199701682T1/xx unknown
- 1996-06-19 HU HU9900061A patent/HU224514B1/hu active IP Right Grant
- 1996-06-19 ES ES00203874T patent/ES2325301T3/es not_active Expired - Lifetime
- 1996-06-19 DE DE69612198T patent/DE69612198T3/de not_active Expired - Lifetime
- 1996-06-19 DK DK00203874T patent/DK1082965T3/da active
- 1996-06-19 EA EA199700413A patent/EA199700413A1/ru unknown
- 1996-06-19 PL PL96324242A patent/PL184872B1/pl unknown
- 1996-06-19 BR BRPI9609414A patent/BRPI9609414B8/pt not_active IP Right Cessation
- 1996-06-19 KR KR1019970709651A patent/KR100425929B1/ko not_active IP Right Cessation
- 1996-06-19 SI SI9630310T patent/SI0833662T2/sl unknown
- 1996-06-21 PE PE1996000474A patent/PE11298A1/es not_active IP Right Cessation
- 1996-06-21 MY MYPI96002531A patent/MY114786A/en unknown
- 1996-06-21 MA MA24292A patent/MA23918A1/fr unknown
- 1996-06-21 AR ARP960103253A patent/AR003006A1/es active IP Right Grant
- 1996-06-22 DZ DZ960099A patent/DZ2055A1/fr active
- 1996-06-22 EG EG57496A patent/EG25924A/xx active
- 1996-06-25 TW TW085107646A patent/TW467746B/zh not_active IP Right Cessation
-
1997
- 1997-12-19 OA OA70169A patent/OA10646A/en unknown
- 1997-12-22 NO NO19976035A patent/NO325169B1/no not_active IP Right Cessation
- 1997-12-23 BG BG102146A patent/BG62720B1/bg unknown
-
1998
- 1998-09-23 HK HK01106309.2A patent/HK1037516A1/xx not_active IP Right Cessation
- 1998-09-23 HK HK98110884A patent/HK1009764A1/xx not_active IP Right Cessation
-
2001
- 2001-06-19 GR GR20010400933T patent/GR3036088T3/el unknown
-
2002
- 2002-09-23 CY CY0200056A patent/CY2297B1/xx unknown
-
2008
- 2008-02-14 JP JP2008033301A patent/JP2008120833A/ja active Pending
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