SK13232002A3 - Použitie pyrido[3,2-e]-pyrazinónov ako inhibítorov fosfodiesterázy 5 na liečbu erektilnej dysfunkcie - Google Patents
Použitie pyrido[3,2-e]-pyrazinónov ako inhibítorov fosfodiesterázy 5 na liečbu erektilnej dysfunkcie Download PDFInfo
- Publication number
- SK13232002A3 SK13232002A3 SK1323-2002A SK13232002A SK13232002A3 SK 13232002 A3 SK13232002 A3 SK 13232002A3 SK 13232002 A SK13232002 A SK 13232002A SK 13232002 A3 SK13232002 A3 SK 13232002A3
- Authority
- SK
- Slovakia
- Prior art keywords
- pyrido
- methoxy
- ethyl
- pyrazinone
- methylimidazo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Reproductive Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gynecology & Obstetrics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10012373A DE10012373A1 (de) | 2000-03-14 | 2000-03-14 | Verwendung von Pyrido[3,2-e]-pyrazinonen als Inhibitoren der Phosphodiesterase 5 zur Therapie von erektiler Dysfunktion |
PCT/EP2001/002485 WO2001068097A1 (de) | 2000-03-14 | 2001-03-06 | VERWENDUNG VON PYRIDO[3,2-e]-PYRAZINONEN ALS INHIBITOREN DER PHOSPHODIESTERASE 5 ZUR THERAPIE VON EREKTILER DYSFUNKTION |
Publications (1)
Publication Number | Publication Date |
---|---|
SK13232002A3 true SK13232002A3 (sk) | 2003-05-02 |
Family
ID=7634668
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK1323-2002A SK13232002A3 (sk) | 2000-03-14 | 2001-03-06 | Použitie pyrido[3,2-e]-pyrazinónov ako inhibítorov fosfodiesterázy 5 na liečbu erektilnej dysfunkcie |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP1267877A1 (bg) |
JP (1) | JP2003528056A (bg) |
AR (1) | AR028250A1 (bg) |
AU (1) | AU2001244192A1 (bg) |
BG (1) | BG107077A (bg) |
BR (1) | BR0109163A (bg) |
CZ (1) | CZ20023078A3 (bg) |
DE (1) | DE10012373A1 (bg) |
HU (1) | HUP0300551A2 (bg) |
IL (1) | IL151646A0 (bg) |
NO (1) | NO20024364L (bg) |
RU (1) | RU2002127413A (bg) |
SK (1) | SK13232002A3 (bg) |
WO (1) | WO2001068097A1 (bg) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0420722D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
TWI417095B (zh) | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | 1,4-二取代之3-氰基-吡啶酮衍生物及其作為mGluR2-受體之正向異位性調節劑之用途 |
TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
US9114138B2 (en) | 2007-09-14 | 2015-08-25 | Janssen Pharmaceuticals, Inc. | 1′,3′-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2H,1′H-[1,4′] bipyridinyl-2′-ones |
EA019085B1 (ru) | 2007-09-14 | 2014-01-30 | Янссен Фармасьютикалз, Инк. | 1',3-двузамещенные 4-(арил-х-фенил)-1н-пиридин-2-оны |
JP2011505366A (ja) | 2007-11-30 | 2011-02-24 | ワイス・エルエルシー | ホスホエステラーゼ10の阻害剤としてのアリールおよびヘテロアリール縮合イミダゾ[1,5−a]ピラジン |
WO2010025890A1 (en) | 2008-09-02 | 2010-03-11 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc | 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors |
AU2009319387B2 (en) | 2008-11-28 | 2012-05-10 | Addex Pharma S.A. | Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors |
CA2760259C (en) | 2009-05-12 | 2018-05-01 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
JP5634506B2 (ja) | 2009-05-12 | 2014-12-03 | ジャンセン ファーマシューティカルズ, インコーポレイテッド | 1,2,3−トリアゾロ[4,3−a]ピリジン誘導体ならびに神経障害および精神障害の治療または予防のためのその使用 |
MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
JP5852666B2 (ja) | 2010-11-08 | 2016-02-03 | ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド | 1,2,4−トリアゾロ[4,3−a]ピリジン誘導体およびmGluR2受容体のポジティブアロステリックモジュレーターとしてのそれらの使用 |
ES2552455T3 (es) | 2010-11-08 | 2015-11-30 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2 |
JP5852665B2 (ja) | 2010-11-08 | 2016-02-03 | ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド | 1,2,4−トリアゾロ[4,3−a]ピリジン誘導体およびmGluR2受容体のポジティブアロステリックモジュレーターとしてのそれらの使用 |
JP6240180B2 (ja) | 2012-06-18 | 2017-11-29 | ダート・ニューロサイエンス・(ケイマン)・リミテッド | 置換チオフェン−およびフラン−縮合アゾロピリミジン−5−(6h)−オン化合物 |
JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
WO2015110435A1 (en) | 2014-01-21 | 2015-07-30 | Janssen Pharmaceutica Nv | Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use |
LT3096790T (lt) | 2014-01-21 | 2019-10-10 | Janssen Pharmaceutica, N.V. | Deriniai, apimantys 2 potipio metabotropinio glutamaterginio receptoriaus teigiamus alosterinius moduliatorius arba ortosterinius agonistus, ir jų panaudojimas |
JP6420400B2 (ja) * | 2017-04-12 | 2018-11-07 | ダート・ニューロサイエンス・(ケイマン)・リミテッド | 置換ピリジンアゾロピリミジン−5−(6h)−オン化合物 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5055465A (en) * | 1989-05-31 | 1991-10-08 | Berlex Laboratories, Inc. | Imidazoquinoxalinones, their aza analogs and process for their preparation |
AU3767793A (en) * | 1992-04-03 | 1993-11-08 | Yamanouchi Pharmaceutical Co., Ltd. | Fused quinoxalinone derivative and pharmaceutical composition containing the same |
DE4228095A1 (de) * | 1992-08-24 | 1994-03-03 | Asta Medica Ag | Neue 4,5-Dihydro-4-oxo-pyrrolo[1,2-a]chinoxaline und entsprechende Aza-analoga und Verfahren zu deren Herstellung |
DE4338948A1 (de) * | 1993-11-15 | 1995-05-18 | Carlen Judith | Verwendung von PDE-Inhibitoren bei der Behandlung erektiler Dysfunktionen |
DE19510965A1 (de) * | 1995-03-24 | 1996-09-26 | Asta Medica Ag | Neue Pyrido/3,2-e/pyrazinone mit antiasthmatischer Wirksamkeit und Verfahren zu deren Herstellung |
DE19728301A1 (de) * | 1997-07-03 | 1999-01-07 | Dresden Arzneimittel | Verwendung von Inhibitoren der Phosphodiesterase 4 für die Behandlung der allergischen Rhinitis |
-
2000
- 2000-03-14 DE DE10012373A patent/DE10012373A1/de not_active Withdrawn
-
2001
- 2001-03-06 HU HU0300551A patent/HUP0300551A2/hu unknown
- 2001-03-06 BR BR0109163-8A patent/BR0109163A/pt not_active Application Discontinuation
- 2001-03-06 SK SK1323-2002A patent/SK13232002A3/sk unknown
- 2001-03-06 WO PCT/EP2001/002485 patent/WO2001068097A1/de not_active Application Discontinuation
- 2001-03-06 IL IL15164601A patent/IL151646A0/xx unknown
- 2001-03-06 RU RU2002127413/04A patent/RU2002127413A/ru unknown
- 2001-03-06 CZ CZ20023078A patent/CZ20023078A3/cs unknown
- 2001-03-06 EP EP01917067A patent/EP1267877A1/de not_active Withdrawn
- 2001-03-06 AU AU2001244192A patent/AU2001244192A1/en not_active Abandoned
- 2001-03-06 JP JP2001566661A patent/JP2003528056A/ja active Pending
- 2001-03-13 AR ARP010101174A patent/AR028250A1/es unknown
-
2002
- 2002-09-10 BG BG107077A patent/BG107077A/bg unknown
- 2002-09-12 NO NO20024364A patent/NO20024364L/no unknown
Also Published As
Publication number | Publication date |
---|---|
AR028250A1 (es) | 2003-04-30 |
NO20024364D0 (no) | 2002-09-12 |
JP2003528056A (ja) | 2003-09-24 |
AU2001244192A1 (en) | 2001-09-24 |
CZ20023078A3 (cs) | 2003-03-12 |
WO2001068097A1 (de) | 2001-09-20 |
BG107077A (bg) | 2003-05-30 |
BR0109163A (pt) | 2002-11-26 |
DE10012373A1 (de) | 2001-09-20 |
IL151646A0 (en) | 2003-04-10 |
EP1267877A1 (de) | 2003-01-02 |
HUP0300551A2 (hu) | 2003-07-28 |
RU2002127413A (ru) | 2004-02-27 |
NO20024364L (no) | 2002-09-27 |
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