HUP0300551A2 - Pirido[3,2-e]-pirazinon-származékok alkalmazása merevedési zavar terápiája foszfodiészteráz 5 enzim gátlása útján és ezeket tartalmazó gyógyszerkészítmények - Google Patents
Pirido[3,2-e]-pirazinon-származékok alkalmazása merevedési zavar terápiája foszfodiészteráz 5 enzim gátlása útján és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0300551A2 HUP0300551A2 HU0300551A HUP0300551A HUP0300551A2 HU P0300551 A2 HUP0300551 A2 HU P0300551A2 HU 0300551 A HU0300551 A HU 0300551A HU P0300551 A HUP0300551 A HU P0300551A HU P0300551 A2 HUP0300551 A2 HU P0300551A2
- Authority
- HU
- Hungary
- Prior art keywords
- phosphodiesterase
- erectile dysfunction
- compounds
- carbon atoms
- group
- Prior art date
Links
- 201000001881 impotence Diseases 0.000 title abstract 5
- 208000010228 Erectile Dysfunction Diseases 0.000 title abstract 3
- 102000011016 Type 5 Cyclic Nucleotide Phosphodiesterases Human genes 0.000 title abstract 2
- 108010037581 Type 5 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 title abstract 2
- DCBOUXKSNFDXER-UHFFFAOYSA-N 1h-pyrido[2,3-b]pyrazin-2-one Chemical class C1=CC=C2NC(=O)C=NC2=N1 DCBOUXKSNFDXER-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
- 125000002950 monocyclic group Chemical group 0.000 abstract 2
- 101001098806 Dictyostelium discoideum cGMP-specific 3',5'-cGMP phosphodiesterase 3 Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002029 aromatic hydrocarbon group Chemical group 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Reproductive Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gynecology & Obstetrics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10012373A DE10012373A1 (de) | 2000-03-14 | 2000-03-14 | Verwendung von Pyrido[3,2-e]-pyrazinonen als Inhibitoren der Phosphodiesterase 5 zur Therapie von erektiler Dysfunktion |
| PCT/EP2001/002485 WO2001068097A1 (de) | 2000-03-14 | 2001-03-06 | VERWENDUNG VON PYRIDO[3,2-e]-PYRAZINONEN ALS INHIBITOREN DER PHOSPHODIESTERASE 5 ZUR THERAPIE VON EREKTILER DYSFUNKTION |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0300551A2 true HUP0300551A2 (hu) | 2003-07-28 |
Family
ID=7634668
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0300551A HUP0300551A2 (hu) | 2000-03-14 | 2001-03-06 | Pirido[3,2-e]-pirazinon-származékok alkalmazása merevedési zavar terápiája foszfodiészteráz 5 enzim gátlása útján és ezeket tartalmazó gyógyszerkészítmények |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1267877A1 (bg) |
| JP (1) | JP2003528056A (bg) |
| AR (1) | AR028250A1 (bg) |
| AU (1) | AU2001244192A1 (bg) |
| BG (1) | BG107077A (bg) |
| BR (1) | BR0109163A (bg) |
| CZ (1) | CZ20023078A3 (bg) |
| DE (1) | DE10012373A1 (bg) |
| HU (1) | HUP0300551A2 (bg) |
| IL (1) | IL151646A0 (bg) |
| NO (1) | NO20024364L (bg) |
| RU (1) | RU2002127413A (bg) |
| SK (1) | SK13232002A3 (bg) |
| WO (1) | WO2001068097A1 (bg) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0420722D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
| TWI417095B (zh) | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途 |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| UA100126C2 (en) | 2007-09-14 | 2012-11-26 | Аддекс Фарма С.А. | 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h, 1'h-[1, 4'] bipyridinyl-2'-ones |
| PT2200985E (pt) | 2007-09-14 | 2011-07-21 | Ortho Mcneil Janssen Pharm | 4-(aril-x-fenil)-1h-piridin-2-onas 1,3-dissubstituídas |
| EP2225248A1 (en) | 2007-11-30 | 2010-09-08 | Wyeth LLC | Aryl and heteroaryl fused imidazo[1,5-a]pyrazines as inhibitors of phosphodiesterase 10 |
| AU2009289784B2 (en) | 2008-09-02 | 2012-03-22 | Addex Pharma S.A. | 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors |
| BRPI0921333A2 (pt) | 2008-11-28 | 2015-12-29 | Addex Pharmaceuticals Sa | derivados de indol e benzoxazina como moduladores de receptores de glutamato metabotrópicos |
| KR101753826B1 (ko) | 2009-05-12 | 2017-07-04 | 얀센 파마슈티칼즈, 인코포레이티드 | 1,２,４―트리아졸로［４,３―ａ］피리딘 유도체 및 신경정신 질환의 치료 또는 예방을 위한 이들의 용도 |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| BRPI1010831A2 (pt) | 2009-05-12 | 2016-04-05 | Addex Pharmaceuticals Sa | derivados de 1,2,4-triazolo[4,3-a]piridina e seu como moduladores alostéricos positivos de receptores de mglur2 |
| AU2011328203B2 (en) | 2010-11-08 | 2015-03-19 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
| EP2649069B1 (en) | 2010-11-08 | 2015-08-26 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
| ES2536433T3 (es) | 2010-11-08 | 2015-05-25 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2 |
| WO2013192225A1 (en) * | 2012-06-18 | 2013-12-27 | Dart Neuroscience (Cayman) Ltd | Substituted thiophene- and furan-fused azolopyrimidine-5-(6h)-one compounds |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
| MX2016009471A (es) | 2014-01-21 | 2016-10-13 | Janssen Pharmaceutica Nv | Combinaciones que comprenden agonistas ortostericos o moduladores alostericos positivos del receptor glutamatergico metabotropico de subtipo 2 y su uso. |
| HUE045610T2 (hu) | 2014-01-21 | 2020-01-28 | Janssen Pharmaceutica Nv | 2-es altípusú metabotróp glutamáterg receptor pozitív allosztérikus modulátorait vagy ortosztérikus agonistáit tartalmazó kombinációk és alkalmazásuk |
| JP6420400B2 (ja) * | 2017-04-12 | 2018-11-07 | ダート・ニューロサイエンス・（ケイマン）・リミテッド | 置換ピリジンアゾロピリミジン−５−（６ｈ）−オン化合物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5055465A (en) * | 1989-05-31 | 1991-10-08 | Berlex Laboratories, Inc. | Imidazoquinoxalinones, their aza analogs and process for their preparation |
| WO1993020077A1 (en) * | 1992-04-03 | 1993-10-14 | Yamanouchi Pharmaceutical Co., Ltd. | Fused quinoxalinone derivative and pharmaceutical composition containing the same |
| DE4228095A1 (de) * | 1992-08-24 | 1994-03-03 | Asta Medica Ag | Neue 4,5-Dihydro-4-oxo-pyrrolo[1,2-a]chinoxaline und entsprechende Aza-analoga und Verfahren zu deren Herstellung |
| DE4338948A1 (de) * | 1993-11-15 | 1995-05-18 | Carlen Judith | Verwendung von PDE-Inhibitoren bei der Behandlung erektiler Dysfunktionen |
| DE19510965A1 (de) * | 1995-03-24 | 1996-09-26 | Asta Medica Ag | Neue Pyrido/3,2-e/pyrazinone mit antiasthmatischer Wirksamkeit und Verfahren zu deren Herstellung |
| DE19728301A1 (de) * | 1997-07-03 | 1999-01-07 | Dresden Arzneimittel | Verwendung von Inhibitoren der Phosphodiesterase 4 für die Behandlung der allergischen Rhinitis |
-
2000
- 2000-03-14 DE DE10012373A patent/DE10012373A1/de not_active Withdrawn
-
2001
- 2001-03-06 CZ CZ20023078A patent/CZ20023078A3/cs unknown
- 2001-03-06 BR BR0109163-8A patent/BR0109163A/pt not_active Application Discontinuation
- 2001-03-06 SK SK1323-2002A patent/SK13232002A3/sk unknown
- 2001-03-06 JP JP2001566661A patent/JP2003528056A/ja active Pending
- 2001-03-06 IL IL15164601A patent/IL151646A0/xx unknown
- 2001-03-06 AU AU2001244192A patent/AU2001244192A1/en not_active Abandoned
- 2001-03-06 EP EP01917067A patent/EP1267877A1/de not_active Withdrawn
- 2001-03-06 WO PCT/EP2001/002485 patent/WO2001068097A1/de not_active Application Discontinuation
- 2001-03-06 RU RU2002127413/04A patent/RU2002127413A/ru unknown
- 2001-03-06 HU HU0300551A patent/HUP0300551A2/hu unknown
- 2001-03-13 AR ARP010101174A patent/AR028250A1/es unknown
-
2002
- 2002-09-10 BG BG107077A patent/BG107077A/bg unknown
- 2002-09-12 NO NO20024364A patent/NO20024364L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BG107077A (bg) | 2003-05-30 |
| RU2002127413A (ru) | 2004-02-27 |
| IL151646A0 (en) | 2003-04-10 |
| AR028250A1 (es) | 2003-04-30 |
| EP1267877A1 (de) | 2003-01-02 |
| WO2001068097A1 (de) | 2001-09-20 |
| NO20024364L (no) | 2002-09-27 |
| CZ20023078A3 (cs) | 2003-03-12 |
| JP2003528056A (ja) | 2003-09-24 |
| AU2001244192A1 (en) | 2001-09-24 |
| BR0109163A (pt) | 2002-11-26 |
| NO20024364D0 (no) | 2002-09-12 |
| SK13232002A3 (sk) | 2003-05-02 |
| DE10012373A1 (de) | 2001-09-20 |
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