IL151646A0 - Use of pyrido[3,2-e]-pyrazinones as inhibitors of phosphodicesterase 5 for treating erectile dysfunction - Google Patents

Use of pyrido[3,2-e]-pyrazinones as inhibitors of phosphodicesterase 5 for treating erectile dysfunction

Info

Publication number
IL151646A0
IL151646A0 IL15164601A IL15164601A IL151646A0 IL 151646 A0 IL151646 A0 IL 151646A0 IL 15164601 A IL15164601 A IL 15164601A IL 15164601 A IL15164601 A IL 15164601A IL 151646 A0 IL151646 A0 IL 151646A0
Authority
IL
Israel
Prior art keywords
phosphodicesterase
pyrazinones
pyrido
inhibitors
erectile dysfunction
Prior art date
Application number
IL15164601A
Original Assignee
Elbion Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elbion Ag filed Critical Elbion Ag
Publication of IL151646A0 publication Critical patent/IL151646A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL15164601A 2000-03-14 2001-03-06 Use of pyrido[3,2-e]-pyrazinones as inhibitors of phosphodicesterase 5 for treating erectile dysfunction IL151646A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10012373A DE10012373A1 (en) 2000-03-14 2000-03-14 Treating erectile dysfunction using new or known imidazo(1,5-a)pyrido(3,2-e)pyrazinone derivatives, as cGMP-selective phosphodiesterase V inhibitors free of cardiovascular side-effects
PCT/EP2001/002485 WO2001068097A1 (en) 2000-03-14 2001-03-06 Use of pyrido[3,2-e]-pyrazinones as inhibitors of phosphodiesterase 5 for treating erectile dysfunction

Publications (1)

Publication Number Publication Date
IL151646A0 true IL151646A0 (en) 2003-04-10

Family

ID=7634668

Family Applications (1)

Application Number Title Priority Date Filing Date
IL15164601A IL151646A0 (en) 2000-03-14 2001-03-06 Use of pyrido[3,2-e]-pyrazinones as inhibitors of phosphodicesterase 5 for treating erectile dysfunction

Country Status (14)

Country Link
EP (1) EP1267877A1 (en)
JP (1) JP2003528056A (en)
AR (1) AR028250A1 (en)
AU (1) AU2001244192A1 (en)
BG (1) BG107077A (en)
BR (1) BR0109163A (en)
CZ (1) CZ20023078A3 (en)
DE (1) DE10012373A1 (en)
HU (1) HUP0300551A2 (en)
IL (1) IL151646A0 (en)
NO (1) NO20024364L (en)
RU (1) RU2002127413A (en)
SK (1) SK13232002A3 (en)
WO (1) WO2001068097A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0420722D0 (en) 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
AR059898A1 (en) 2006-03-15 2008-05-07 Janssen Pharmaceutica Nv DERIVATIVES OF 3-CIANO-PIRIDONA 1,4-DISUSTITUTED AND ITS USE AS ALLOSTERIC MODULATORS OF MGLUR2 RECEIVERS
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
AU2008297876B2 (en) 2007-09-14 2011-07-07 Addex Pharma S.A. 1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones
BRPI0816767B8 (en) 2007-09-14 2021-05-25 Addex Pharmaceuticals Sa compound 4-phenyl-3,4,5,6-tetrahydro-2h,1'h-[1,4']bipyridinyl-2'-disubstituted 1',3'-ones, pharmaceutical composition and use of same
CA2706866A1 (en) 2007-11-30 2009-06-04 Biotie Therapies Gmbh Aryl and heteroaryl fused imidazo[1,5-a]pyrazines as inhibitors of phosphodiesterase 10
AU2009289784B2 (en) 2008-09-02 2012-03-22 Addex Pharma S.A. 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
WO2010060589A1 (en) 2008-11-28 2010-06-03 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
US8946205B2 (en) 2009-05-12 2015-02-03 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
MY161325A (en) 2009-05-12 2017-04-14 Janssen Pharmaceuticals Inc 1, 2, 4-triazolo[4,3-a]pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders
PL2649069T3 (en) 2010-11-08 2016-01-29 Janssen Pharmaceuticals Inc 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
CN103261195B (en) 2010-11-08 2015-09-02 杨森制药公司 The purposes of 1,2,4-triazolo [4,3-a] pyridine derivate and the positive allosteric modulators as MGLUR2 acceptor thereof
AU2011328203B2 (en) 2010-11-08 2015-03-19 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
RU2653054C2 (en) 2012-06-18 2018-05-07 Дарт Нейросайенс (Кайман) Лтд Substituted compounds of pyridine azolopyrimidine-5-(6h)-one
JO3368B1 (en) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
JO3367B1 (en) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv 1,2,4-TRIAZOLO[4,3-a]PYRIDINE COMPOUNDS AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
UA121965C2 (en) 2014-01-21 2020-08-25 Янссен Фармацевтика Нв Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
KR102461134B1 (en) 2014-01-21 2022-10-28 얀센 파마슈티카 엔.브이. Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
JP6420400B2 (en) * 2017-04-12 2018-11-07 ダート・ニューロサイエンス・（ケイマン）・リミテッド Substituted pyridine azolopyrimidin-5- (6H) -one compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5055465A (en) * 1989-05-31 1991-10-08 Berlex Laboratories, Inc. Imidazoquinoxalinones, their aza analogs and process for their preparation
AU3767793A (en) * 1992-04-03 1993-11-08 Yamanouchi Pharmaceutical Co., Ltd. Fused quinoxalinone derivative and pharmaceutical composition containing the same
DE4228095A1 (en) * 1992-08-24 1994-03-03 Asta Medica Ag New 4,5-dihydro-4-oxopyrrolo [1,2-a] quinoxalines and corresponding aza analogues and processes for their preparation
DE4338948A1 (en) * 1993-11-15 1995-05-18 Carlen Judith Treating erectile dysfunction without causing side-effects
DE19510965A1 (en) * 1995-03-24 1996-09-26 Asta Medica Ag New pyrido / 3,2-e / pyrazinone with anti-asthmatic activity and process for their preparation
DE19728301A1 (en) * 1997-07-03 1999-01-07 Dresden Arzneimittel Use of inhibitors of phosphodiesterase 4 for the treatment of allergic rhinitis

Also Published As

Publication number Publication date
CZ20023078A3 (en) 2003-03-12
DE10012373A1 (en) 2001-09-20
HUP0300551A2 (en) 2003-07-28
RU2002127413A (en) 2004-02-27
EP1267877A1 (en) 2003-01-02
AR028250A1 (en) 2003-04-30
NO20024364D0 (en) 2002-09-12
JP2003528056A (en) 2003-09-24
AU2001244192A1 (en) 2001-09-24
NO20024364L (en) 2002-09-27
BG107077A (en) 2003-05-30
BR0109163A (en) 2002-11-26
WO2001068097A1 (en) 2001-09-20
SK13232002A3 (en) 2003-05-02

Similar Documents

Publication Publication Date Title
IL151646A0 (en) Use of pyrido[3,2-e]-pyrazinones as inhibitors of phosphodicesterase 5 for treating erectile dysfunction
IL138907A0 (en) Pyrazolopyrimidinone cgmp pde5 inhibitors for the treatment of sexual dysfunction
IL152873A0 (en) beta-CARBOLINE DERIVATIVES USEFUL AS INHIBITORS OF PHOSPHODIESTERASE
EP1027054A4 (en) Local administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction
AU2001250821A1 (en) Methods and compositions for the treatment and prevention of erectile dysfunction
AU4314199A (en) Compounds, compositions and methods for treating erectile dysfunction
HUP0200912A3 (en) Compositions comprising phosphodiesterase inhibitors for the treatment of sexual disfunction
ZA200007019B (en) Use of prostaglandin agonists to treat erectile dysfunction or impotence.
HUP0300477A3 (en) Daily treatment for erectile dysfunction using a composition containing pde5 inhibitors
IL162154A0 (en) Prostagandin composition for the treatment of erectile dysfunction
EP1677754A4 (en) Methods and compositions for treating erectile dysfunction
AU3048501A (en) An improved pharmaceutical composition for treating male erectile dysfunction
EP1161255A4 (en) Methods and compositions for treating erectile dysfunction
IL154642A0 (en) Treatment of urinary dysfunction
WO2002041894A3 (en) Selective dopamine d4 receptor agonists for treating sexual dysfunction
AU2002246924A8 (en) Treatment of erectile dysfunction with rho-kinase inhibitors
PL362980A1 (en) Treatment of sexual dysfunction
AU8906201A (en) Methods and compositions for the treatment and prevention of sexual dysfunction
AU2000275972A1 (en) Pde iii inhibitors for treating sexual dysfunction
AU2001237379A1 (en) Use of benzothieno-2,3-D-pyrimidines with PDE V inhibitory effect for the treatment of erectile dysfunction
ZA200203069B (en) Peptides for treatment of erectile dysfunction.
EP1223957A4 (en) A method of treating erectile dysfunction
EP1395593A4 (en) Novel pyrazolopyrimidinethione derivatives. preparation methods thereof and their use as therapeutics for erectile dysfunction
AU2001281396A1 (en) Novel compositions and methods for treatment of male erectile dysfunction
ZA992793B (en) Pyrazolopyrimidinone cGMP PDE5 inhibitors for the treatment of sexual dysfunction.

Legal Events

Date Code Title Description
HC Change of name of proprietor(s)

Owner name: ELBION GMBH

Free format text: FORMER NAME:ELBION AG