SI7810823A8 - Process for preparing hydroxy ethyl starch suitable as blood plasma expander - Google Patents
Process for preparing hydroxy ethyl starch suitable as blood plasma expander Download PDFInfo
- Publication number
- SI7810823A8 SI7810823A8 SI7810823A SI7810823A SI7810823A8 SI 7810823 A8 SI7810823 A8 SI 7810823A8 SI 7810823 A SI7810823 A SI 7810823A SI 7810823 A SI7810823 A SI 7810823A SI 7810823 A8 SI7810823 A8 SI 7810823A8
- Authority
- SI
- Slovenia
- Prior art keywords
- starch
- hydroxyethyl starch
- acetone
- sodium chloride
- room temperature
- Prior art date
Links
- 229920001612 Hydroxyethyl starch Polymers 0.000 title claims abstract description 33
- 229940050526 hydroxyethylstarch Drugs 0.000 title claims abstract description 33
- 239000003058 plasma substitute Substances 0.000 title claims description 9
- 210000002381 plasma Anatomy 0.000 title claims description 8
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- DNZMDASEFMLYBU-RNBXVSKKSA-N hydroxyethyl starch Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O.OCCOC[C@H]1O[C@H](OCCO)[C@H](OCCO)[C@@H](OCCO)[C@@H]1OCCO DNZMDASEFMLYBU-RNBXVSKKSA-N 0.000 title description 2
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims abstract description 24
- 238000006386 neutralization reaction Methods 0.000 claims abstract description 9
- 239000002904 solvent Substances 0.000 claims abstract description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 36
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 27
- 238000000034 method Methods 0.000 claims description 14
- 239000011780 sodium chloride Substances 0.000 claims description 13
- 229920002472 Starch Polymers 0.000 claims description 11
- 239000008107 starch Substances 0.000 claims description 11
- 235000019698 starch Nutrition 0.000 claims description 11
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 10
- 239000000243 solution Substances 0.000 claims description 10
- 238000002360 preparation method Methods 0.000 claims description 7
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 6
- 229920002261 Corn starch Polymers 0.000 claims description 5
- 238000006243 chemical reaction Methods 0.000 claims description 5
- 239000000047 product Substances 0.000 claims description 5
- 239000008120 corn starch Substances 0.000 claims description 4
- 239000002244 precipitate Substances 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 3
- 238000006467 substitution reaction Methods 0.000 claims description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 2
- 229920000945 Amylopectin Polymers 0.000 claims 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 2
- 239000007864 aqueous solution Substances 0.000 claims 2
- 229940099112 cornstarch Drugs 0.000 claims 2
- 238000005530 etching Methods 0.000 claims 2
- 239000008103 glucose Substances 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims 2
- IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical group OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical group C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- LKDRXBCSQODPBY-ARQDHWQXSA-N beta-D-fructopyranose Chemical compound OC[C@@]1(O)OC[C@@H](O)[C@@H](O)[C@@H]1O LKDRXBCSQODPBY-ARQDHWQXSA-N 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- LKDRXBCSQODPBY-UHFFFAOYSA-N laevosan Natural products OCC1(O)OCC(O)C(O)C1O LKDRXBCSQODPBY-UHFFFAOYSA-N 0.000 claims 1
- 150000003839 salts Chemical class 0.000 abstract description 4
- 239000004606 Fillers/Extenders Substances 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
- 235000002639 sodium chloride Nutrition 0.000 description 12
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 10
- 239000000706 filtrate Substances 0.000 description 10
- 238000003756 stirring Methods 0.000 description 8
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 238000001035 drying Methods 0.000 description 5
- 229910052757 nitrogen Inorganic materials 0.000 description 5
- 239000011541 reaction mixture Substances 0.000 description 5
- 239000000203 mixture Substances 0.000 description 3
- 239000011347 resin Substances 0.000 description 3
- 229920005989 resin Polymers 0.000 description 3
- 102000013142 Amylases Human genes 0.000 description 2
- 108010065511 Amylases Proteins 0.000 description 2
- 238000005903 acid hydrolysis reaction Methods 0.000 description 2
- 239000012670 alkaline solution Substances 0.000 description 2
- 235000019418 amylase Nutrition 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 238000011046 pyrogen test Methods 0.000 description 2
- 230000001698 pyrogenic effect Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 239000004382 Amylase Substances 0.000 description 1
- 229920000856 Amylose Polymers 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 206010048643 Hypereosinophilic syndrome Diseases 0.000 description 1
- 235000019759 Maize starch Nutrition 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000906446 Theraps Species 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 229940025131 amylases Drugs 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 239000000644 isotonic solution Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/718—Starch or degraded starch, e.g. amylose, amylopectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B31/00—Preparation of derivatives of starch
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B31/00—Preparation of derivatives of starch
- C08B31/08—Ethers
- C08B31/12—Ethers having alkyl or cycloalkyl radicals substituted by heteroatoms, e.g. hydroxyalkyl or carboxyalkyl starch
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT248977A AT348548B (de) | 1977-04-08 | 1977-04-08 | Verfahren zur herstellung von alsblutplasma- expander geeignerter hydroxyaethylstaerke |
| YU823/78A YU40514B (en) | 1977-04-08 | 1978-04-06 | Process for preparing hydroxy ethyl starch suitable as blood plasma expander |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI7810823A8 true SI7810823A8 (en) | 1994-12-31 |
Family
ID=3535207
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI7810823A SI7810823A8 (en) | 1977-04-08 | 1978-04-06 | Process for preparing hydroxy ethyl starch suitable as blood plasma expander |
Country Status (20)
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4431800A (en) * | 1982-03-30 | 1984-02-14 | General Foods Corporation | Process for hydroxypropylating starch |
| DE3428201A1 (de) * | 1984-07-31 | 1986-02-06 | Laevosan-Gesellschaft mbH & Co. KG, Linz | Loesungen fuer die peritonealdialyse |
| SE462100B (sv) * | 1985-08-08 | 1990-05-07 | Perstorp Ab | Komposition och dess anvaendning i ett tvaa- eller flerfassystem |
| DE19975071I2 (de) * | 1989-06-16 | 2000-02-03 | Fresenius Ag | Hydroxyethylstaerke als Plasmaexpander Verfahren zu ihrer Herstellung und Verwendung als kolloidales Plasmaersatzmittel |
| GB9121559D0 (en) * | 1991-10-10 | 1991-11-27 | Dowty Defence & Air Syst | Pumps |
| US6051700A (en) * | 1999-02-11 | 2000-04-18 | Grain Processing Corporation | Process and method for hydroxyalkylation of starch and hydroxyalkyl starch prepared accordingly |
| US6746836B1 (en) * | 2000-12-08 | 2004-06-08 | Abe Widra | Alpha-keratose as a blood plasma expander and use thereof |
| RU2245714C1 (ru) * | 2003-09-04 | 2005-02-10 | Панов Валерий Петрович | Лекарственное средство волемического действия и способ его получения |
| US20090176708A1 (en) | 2007-12-27 | 2009-07-09 | Peter Turecek | Chemically modified factor ix |
| CN102617743B (zh) * | 2012-03-31 | 2015-02-18 | 李育强 | 一种羟乙基淀粉的制备方法 |
| CN103588888A (zh) * | 2013-11-17 | 2014-02-19 | 石家庄四药有限公司 | 一种中低分子量羟乙基淀粉的制备方法 |
| DE202016102800U1 (de) | 2016-05-25 | 2016-09-02 | Joint-Stock Company "MEDPOLYMER" | Plasma Ersatzlösung |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR88043E (fr) * | 1964-07-20 | 1966-06-17 | Staley Mfg Co A E | Préparation d'éthers d'amylose par éthérification catalytique d'une solution aqueuse d'amylose |
| US3414530A (en) * | 1965-12-23 | 1968-12-03 | Agriculture Usa | Graft polymers of polyalkylene oxides on starch and dextrin |
| US3523938A (en) * | 1967-12-13 | 1970-08-11 | American Hospital Supply Corp | Starch plasma expanders and process of preparation |
| JPS538750B2 (enrdf_load_stackoverflow) * | 1971-08-18 | 1978-03-31 | ||
| US3937821A (en) * | 1971-08-21 | 1976-02-10 | Kyorin Seiyaku Kabushiki Kaisha | Plasma substitute including artificial starch and method for the preparation thereof |
| JPS495193A (enrdf_load_stackoverflow) * | 1972-05-02 | 1974-01-17 | ||
| DE2260785A1 (de) * | 1972-12-12 | 1974-06-20 | Morishita Pharma | Verfahren zur herstellung von hydroxyaethylstaerke, die in der 6-stellung des glucoserings durch viele hydroxyaethylgruppen substituiert ist |
| JPS5160284A (ja) * | 1974-11-25 | 1976-05-26 | Ajinomoto Kk | Sohidorokishechirukadenpunno seiseiho |
-
1977
- 1977-04-08 AT AT248977A patent/AT348548B/de not_active IP Right Cessation
-
1978
- 1978-03-29 NL NLAANVRAGE7803334,A patent/NL188753C/xx not_active IP Right Cessation
- 1978-03-30 IL IL54388A patent/IL54388A/xx unknown
- 1978-03-31 DE DE19782814032 patent/DE2814032A1/de active Granted
- 1978-04-03 GB GB12893/78A patent/GB1551807A/en not_active Expired
- 1978-04-03 CS CS782142A patent/CS193499B2/cs unknown
- 1978-04-04 SU SU782596657A patent/SU797586A3/ru active
- 1978-04-05 CA CA300,511A patent/CA1092603A/en not_active Expired
- 1978-04-05 IT IT21997/78A patent/IT1094297B/it active
- 1978-04-06 YU YU823/78A patent/YU40514B/xx unknown
- 1978-04-06 FR FR7810290A patent/FR2386558A1/fr active Granted
- 1978-04-06 SE SE7803892A patent/SE430068B/sv not_active IP Right Cessation
- 1978-04-06 DD DD78204634A patent/DD135352A5/xx unknown
- 1978-04-06 SI SI7810823A patent/SI7810823A8/sl unknown
- 1978-04-06 JP JP4373378A patent/JPS5460385A/ja active Granted
- 1978-04-07 FI FI781058A patent/FI63762C/fi not_active IP Right Cessation
- 1978-04-07 HU HU78LA933A patent/HU176274B/hu not_active IP Right Cessation
- 1978-04-07 US US05/894,447 patent/US4167622A/en not_active Expired - Lifetime
- 1978-04-07 DK DK155178A patent/DK158791C/da not_active IP Right Cessation
- 1978-04-07 CH CH379078A patent/CH632281A5/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE2814032A1 (de) | 1978-10-19 |
| FI781058A7 (fi) | 1978-10-09 |
| SU797586A3 (ru) | 1981-01-15 |
| US4167622A (en) | 1979-09-11 |
| DK158791B (da) | 1990-07-16 |
| DD135352A5 (de) | 1979-05-02 |
| NL188753C (nl) | 1992-09-16 |
| IT1094297B (it) | 1985-07-26 |
| SE430068B (sv) | 1983-10-17 |
| FI63762B (fi) | 1983-04-29 |
| IL54388A (en) | 1981-07-31 |
| NL7803334A (nl) | 1978-10-10 |
| AT348548B (de) | 1979-02-26 |
| YU40514B (en) | 1986-02-28 |
| GB1551807A (en) | 1979-08-30 |
| FI63762C (fi) | 1983-08-10 |
| JPS6334161B2 (enrdf_load_stackoverflow) | 1988-07-08 |
| CH632281A5 (de) | 1982-09-30 |
| FR2386558B1 (enrdf_load_stackoverflow) | 1980-08-08 |
| YU82378A (en) | 1984-02-29 |
| DK155178A (da) | 1978-10-09 |
| CS193499B2 (en) | 1979-10-31 |
| DK158791C (da) | 1990-12-03 |
| SE7803892L (sv) | 1978-10-09 |
| DE2814032C2 (enrdf_load_stackoverflow) | 1989-12-14 |
| FR2386558A1 (fr) | 1978-11-03 |
| IT7821997A0 (it) | 1978-04-05 |
| ATA248977A (de) | 1978-07-15 |
| CA1092603A (en) | 1980-12-30 |
| IL54388A0 (en) | 1978-06-15 |
| HU176274B (en) | 1981-01-28 |
| JPS5460385A (en) | 1979-05-15 |
| NL188753B (nl) | 1992-04-16 |
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