SI3774862T1 - Novi analogi GLP-1 - Google Patents

Novi analogi GLP-1

Info

Publication number
SI3774862T1
SI3774862T1 SI201930322T SI201930322T SI3774862T1 SI 3774862 T1 SI3774862 T1 SI 3774862T1 SI 201930322 T SI201930322 T SI 201930322T SI 201930322 T SI201930322 T SI 201930322T SI 3774862 T1 SI3774862 T1 SI 3774862T1
Authority
SI
Slovenia
Prior art keywords
analogs
new glp
glp
new
Prior art date
Application number
SI201930322T
Other languages
English (en)
Slovenian (sl)
Inventor
Rajamannar Thennati
Nishith Chaturvedi
Vinod Sampatrao Burade
Pradeep Dinesh Shahi
Muthukumaran Natarajan
Ravishankara Madavati Nagaraja
Rishit Mansukhlal Zalawadia
Kunal Pandya
Brijeshkumar Patel
Dhiren Rameshchandra Joshi
Krunal Harishbhai Soni
Abhishek Tiwari
Vipulkumar Shankarbhai Patel
Original Assignee
Sun Pharmaceutical Industries Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sun Pharmaceutical Industries Limited filed Critical Sun Pharmaceutical Industries Limited
Publication of SI3774862T1 publication Critical patent/SI3774862T1/sl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/605Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/26Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Transmission And Conversion Of Sensor Element Output (AREA)
SI201930322T 2018-04-05 2019-04-05 Novi analogi GLP-1 SI3774862T1 (sl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IN201821013109 2018-04-05
IN201821040474 2018-10-26
IN201821040468 2018-10-26
EP19724915.4A EP3774862B1 (en) 2018-04-05 2019-04-05 Novel glp-1 analogues
PCT/IB2019/052835 WO2019193576A1 (en) 2018-04-05 2019-04-05 Novel glp-1 analogues

Publications (1)

Publication Number Publication Date
SI3774862T1 true SI3774862T1 (sl) 2022-10-28

Family

ID=66589592

Family Applications (2)

Application Number Title Priority Date Filing Date
SI201930322T SI3774862T1 (sl) 2018-04-05 2019-04-05 Novi analogi GLP-1
SI201930764T SI4122954T1 (sl) 2018-04-05 2019-04-05 Novi analogi GLP-1

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI201930764T SI4122954T1 (sl) 2018-04-05 2019-04-05 Novi analogi GLP-1

Country Status (33)

Country Link
US (7) US11447535B2 (https=)
EP (3) EP4364751A3 (https=)
JP (2) JP7250814B2 (https=)
KR (2) KR20250065720A (https=)
CN (3) CN117964735A (https=)
AU (3) AU2019247936C1 (https=)
BR (1) BR112020020419A2 (https=)
CA (1) CA3095988A1 (https=)
CL (1) CL2020002574A1 (https=)
CO (1) CO2020012425A2 (https=)
CY (1) CY1125528T1 (https=)
DK (2) DK3774862T3 (https=)
EC (1) ECSP20070185A (https=)
ES (2) ES2925678T3 (https=)
FI (1) FI4122954T3 (https=)
HR (2) HRP20240749T1 (https=)
HU (2) HUE060135T2 (https=)
IL (1) IL277483B1 (https=)
JO (1) JOP20200251B1 (https=)
LT (2) LT3774862T (https=)
MX (2) MX2020010505A (https=)
MY (1) MY202560A (https=)
PE (1) PE20211417A1 (https=)
PH (1) PH12020551591A1 (https=)
PL (2) PL4122954T3 (https=)
PT (2) PT4122954T (https=)
RS (2) RS65639B1 (https=)
SG (1) SG11202009467YA (https=)
SI (2) SI3774862T1 (https=)
SM (2) SMT202400241T1 (https=)
UA (1) UA128210C2 (https=)
WO (1) WO2019193576A1 (https=)
ZA (1) ZA202306729B (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2020010505A (es) * 2018-04-05 2021-01-15 Sun Pharmaceutical Ind Ltd Analogos novedosos de glp-1.
TWI829687B (zh) 2018-05-07 2024-01-21 丹麥商諾佛 儂迪克股份有限公司 包含glp-1促效劑與n-(8-(2-羥基苯甲醯基)胺基)辛酸之鹽的固體組成物
WO2020180534A1 (en) 2019-03-01 2020-09-10 President And Fellows Of Harvard College Methods and compositions for protein delivery
TW202216746A (zh) * 2020-06-22 2022-05-01 印度商太陽製藥工業有限公司 長效型glp-1/gip雙重促效劑
PE20231309A1 (es) * 2020-10-17 2023-08-24 Sun Pharmaceutical Ind Ltd Agonistas duales glp-1/gip
CN114685646B (zh) * 2020-12-31 2023-04-07 厦门赛诺邦格生物科技股份有限公司 一种多肽侧链类似物的制备方法及其应用
CA3204051A1 (en) 2021-01-20 2022-07-28 Brian Lian Compositions and methods for the treatment of metabolic and liver disorders
JP7642830B2 (ja) 2021-09-15 2025-03-10 バイキング・セラピューティクス・インコーポレイテッド 代謝及び肝臓障害の処置のための組成物及び方法
AU2022386166A1 (en) 2021-11-10 2024-06-20 I2O Therapeutics, Inc. Ionic liquid compositions
CN116514952B (zh) * 2022-10-13 2024-02-02 江苏师范大学 一类glp-1类似物及其应用
KR20260022948A (ko) 2023-06-09 2026-02-20 썬 파마슈티컬 인더스트리스 리미티드 Glp-1/gip 이중 수용체 작용제, glp-1/gcg 이중 수용체 작용제, 및 glp-1/gip/gcg 삼중 수용체 작용제
EP4731244A1 (en) 2023-06-20 2026-04-29 Sun Pharmaceutical Industries Limited Glp-1 analog for use in the treatment of metabolic disorders
CN117756914B (zh) * 2023-12-15 2024-09-03 瀚晖制药有限公司 依柯胰岛素的制备方法
WO2025163615A1 (en) 2024-01-31 2025-08-07 Sun Pharmaceutical Industries Ltd. High level production of glp1 analogues

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6849708B1 (en) 1986-05-05 2005-02-01 The General Hospital Corporation Insulinotropic hormone and uses thereof
US6268343B1 (en) 1996-08-30 2001-07-31 Novo Nordisk A/S Derivatives of GLP-1 analogs
IL128332A0 (en) 1996-08-30 2000-01-31 Novo Nordisk As GLP-1 derivatives
EP1056774A1 (en) 1998-02-27 2000-12-06 Novo Nordisk A/S N-terminally truncated glp-1 derivatives
JP2002506792A (ja) 1998-02-27 2002-03-05 ノボ ノルディスク アクティーゼルスカブ N末端修飾glp−1誘導体
JP2003522099A (ja) 1998-02-27 2003-07-22 ノボ ノルディスク アクティーゼルスカブ 遅延作用プロファイルを有するglp−1のglp−1誘導体及びエキセンジン
WO1999043706A1 (en) 1998-02-27 1999-09-02 Novo Nordisk A/S Derivatives of glp-1 analogs
FR2777283B1 (fr) 1998-04-10 2000-11-24 Adir Nouveaux composes peptidiques analogues du glucagon-peptide- 1 (7-37), leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CZ295044B6 (cs) 1998-12-07 2005-05-18 Societe De Conseils De Recherches Et D'application Analogy GLP-1, mající kyselinu aminoizomáselnou na pozicích 8 a 35, jejich použití a farmaceutické prostředky je obsahující
JP4716641B2 (ja) 2000-06-16 2011-07-06 イーライ リリー アンド カンパニー グルカゴン様ペプチド−1類似体
IL155812A0 (en) 2000-12-07 2003-12-23 Lilly Co Eli Glp-1 fusion proteins
AU2003200839B2 (en) 2002-01-08 2008-12-11 Eli Lilly And Company Extended glucagon-like peptide-1 analogs
JPWO2004037859A1 (ja) 2002-10-11 2006-02-23 株式会社三和化学研究所 Glp−1誘導体及びその経粘膜吸収型製剤
EP1626981A4 (en) 2003-03-04 2006-11-22 Biorexis Pharmaceutical Corp PROTEINS PROTECTED AGAINST DIPEPTIDYLPEPTIDASE
ATE549028T1 (de) 2003-05-15 2012-03-15 Tufts College Stabile analoga von glp-1
BR122019021416A2 (https=) 2003-09-19 2019-12-21
JP2007536214A (ja) 2003-12-16 2007-12-13 ソシエテ・ドゥ・コンセイユ・ドゥ・ルシェルシュ・エ・ダプリカーション・シャンティフィック・エス・ア・エス Glp−1類似体
WO2006037810A2 (en) 2004-10-07 2006-04-13 Novo Nordisk A/S Protracted glp-1 compounds
TWI362392B (en) 2005-03-18 2012-04-21 Novo Nordisk As Acylated glp-1 compounds
US8603972B2 (en) 2005-03-18 2013-12-10 Novo Nordisk A/S Extended GLP-1 compounds
CA2607566A1 (en) 2005-05-06 2006-11-16 Bayer Pharmaceuticals Corporation Glucagon-like peptide 1 (glp-1) receptor agonists and their pharmacological methods of use
US8318668B2 (en) 2005-09-08 2012-11-27 Trustees Of Tufts College Stabilized GLP-1 analogs
DE602005017628D1 (de) 2005-09-22 2009-12-24 Biocompatibles Uk Ltd Fusionspolypeptide vom glp-1 (glucagon-like peptide-1) mit erhöhten peptidaseresistenz
WO2009030771A1 (en) 2007-09-05 2009-03-12 Novo Nordisk A/S Peptides derivatized with a-b-c-d- and their therapeutical use
MX2010004298A (es) 2007-10-30 2010-05-03 Univ Indiana Res & Tech Corp Compuestos que exhiben actividad antagonista de glucagon y agonista de glp-1.
JP6006118B2 (ja) 2009-12-16 2016-10-12 ノヴォ ノルディスク アー/エス Glp−1アナログ及び誘導体
AU2011247824B2 (en) 2010-04-27 2014-02-13 Betta Pharmaceuticals Co., Ltd Glucagon-like peptide-1 analogue and use thereof
WO2012016419A1 (zh) 2010-08-06 2012-02-09 浙江贝达药业有限公司 Glp-1衍生物及其应用
JP6039569B2 (ja) 2010-11-09 2016-12-07 ノヴォ ノルディスク アー/エス 二重アシル化されたglp−1誘導体
PL2696687T3 (pl) 2011-04-12 2017-06-30 Novo Nordisk A/S Pochodne podwójnie acylowanej GLP-1
WO2012150503A2 (en) 2011-05-03 2012-11-08 Zealand Pharma A/S Glu-glp-1 dual agonist signaling-selective compounds
JP6126097B2 (ja) 2011-09-06 2017-05-10 ノヴォ ノルディスク アー/エス Glp−1誘導体
EP2578599A1 (en) 2011-10-07 2013-04-10 LanthioPep B.V. Cyclic analogs of GLP-1 and GLP-1 related peptides
CN104411322B (zh) 2012-05-08 2017-05-24 诺和诺德股份有限公司 双酰化glp‑1衍生物
EP2846823B1 (en) 2012-05-08 2019-12-04 Novo Nordisk A/S Double-acylated glp-1 derivatives
SG11201407860PA (en) 2012-06-14 2014-12-30 Sanofi Sa Exendin-4 peptide analogues
UA116217C2 (uk) 2012-10-09 2018-02-26 Санофі Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
TWI617574B (zh) 2012-12-11 2018-03-11 梅迪繆思有限公司 用於治療肥胖之升糖素與glp-1共促效劑
AU2013366692B2 (en) 2012-12-21 2017-11-23 Sanofi Dual GLP1/GIP or trigonal GLP1/GIP/Glucagon agonists
JP6475233B2 (ja) 2013-06-20 2019-02-27 ノヴォ ノルディスク アー/エス Glp−1誘導体及びその使用
US9738697B2 (en) 2013-06-23 2017-08-22 Wisconsin Alumni Research Foundation Alpha/beta-polypeptide analogs of glucagon-like peptide-1
EP3016975B1 (en) 2013-07-04 2019-01-16 Novo Nordisk A/S Derivatives of glp-1 like peptides, and uses thereof
EP3033112B1 (en) 2013-08-15 2020-10-07 Novo Nordisk A/S Glp-1 derivatives, and uses thereof
PL3057984T3 (pl) * 2013-10-17 2018-12-31 Zealand Pharma A/S Acylowane analogi glukagonu
WO2015086733A1 (en) 2013-12-13 2015-06-18 Sanofi Dual glp-1/glucagon receptor agonists
CN105849123A (zh) 2013-12-13 2016-08-10 免疫医疗有限公司 蛋白酶抗性肽
TW201609800A (zh) 2013-12-13 2016-03-16 賽諾菲公司 做為雙重glp-1/升糖素受體促效劑之艾塞那肽-4胜肽類似物
JP6730278B2 (ja) 2014-11-27 2020-07-29 ノヴォ ノルディスク アー/エス Glp−1誘導体及びその使用
WO2016097108A1 (en) 2014-12-17 2016-06-23 Novo Nordisk A/S Glp-1 derivatives and uses thereof
TWI726889B (zh) 2015-06-10 2021-05-11 英商梅迪繆思有限公司 蛋白酶抗性之脂化肽
WO2017035432A1 (en) 2015-08-26 2017-03-02 Robert Doyle Coagonists of glucagon-like peptide 1 receptor and neuropeptide y2 receptor
US10946074B2 (en) 2016-03-03 2021-03-16 Novo Nordisk A/S GLP-1 derivatives and uses thereof
MX2018014966A (es) 2016-06-09 2019-08-14 Medimmune Ltd Peptidos monolipidados resistentes a proteasas.
ES2828526T3 (es) 2016-11-07 2021-05-26 Novo Nordisk As Esteres activos DCHBS de compuestos PEG y sus usos
TW201833131A (zh) 2016-12-02 2018-09-16 法商賽諾菲公司 作為胜肽類glp1/升糖素/gip受體促效劑之新化合物
WO2018178796A1 (en) 2017-03-27 2018-10-04 Sun Pharmaceutical Industries Limited Method for making kex1 protease sensitive polypeptides using yeast strain
JP2021516556A (ja) 2018-03-09 2021-07-08 エンザイペプ ビー.ブイ. リラグルチド、セマグルチド及びglp−1の化学酵素合成
MX2020010505A (es) * 2018-04-05 2021-01-15 Sun Pharmaceutical Ind Ltd Analogos novedosos de glp-1.

Also Published As

Publication number Publication date
RS65639B1 (sr) 2024-07-31
JOP20200251A1 (ar) 2020-10-04
BR112020020419A2 (pt) 2021-01-19
CN112236444A (zh) 2021-01-15
EP3774862A1 (en) 2021-02-17
JP2023078367A (ja) 2023-06-06
PT3774862T (pt) 2022-09-05
SMT202200352T1 (it) 2022-09-14
EP4122954B1 (en) 2024-04-03
RS63523B1 (sr) 2022-09-30
PT4122954T (pt) 2024-06-05
CN120554480A (zh) 2025-08-29
US20220402992A1 (en) 2022-12-22
ZA202306729B (en) 2024-03-27
CL2020002574A1 (es) 2021-06-04
US20240199718A1 (en) 2024-06-20
US11866477B2 (en) 2024-01-09
AU2019247936B2 (en) 2023-03-02
MY202560A (en) 2024-05-08
SG11202009467YA (en) 2020-10-29
SI4122954T1 (sl) 2024-07-31
AU2023203430B2 (en) 2025-07-03
KR20200141469A (ko) 2020-12-18
JP2021520346A (ja) 2021-08-19
US20240376175A1 (en) 2024-11-14
US20200362007A1 (en) 2020-11-19
AU2019247936C1 (en) 2023-06-15
KR20250065720A (ko) 2025-05-13
EP4122954A1 (en) 2023-01-25
KR102801994B1 (ko) 2025-04-30
CN117964735A (zh) 2024-05-03
CN112236444B (zh) 2025-09-19
PH12020551591A1 (en) 2021-08-16
HUE067499T2 (hu) 2024-10-28
FI4122954T3 (fi) 2024-06-18
IL277483B1 (en) 2026-01-01
US11447535B2 (en) 2022-09-20
UA128210C2 (uk) 2024-05-08
WO2019193576A1 (en) 2019-10-10
PL4122954T3 (pl) 2024-08-12
MX2020010505A (es) 2021-01-15
CO2020012425A2 (es) 2020-12-21
JP7250814B2 (ja) 2023-04-03
ES2980707T3 (es) 2024-10-02
JOP20200251B1 (ar) 2024-04-18
IL277483A (en) 2020-11-30
HRP20240749T1 (hr) 2024-09-13
NZ768446A (en) 2025-10-31
AU2023203430A1 (en) 2023-06-29
EP3774862B1 (en) 2022-06-08
CA3095988A1 (en) 2019-10-10
LT3774862T (lt) 2022-09-12
DK4122954T3 (da) 2024-06-10
AU2019247936A1 (en) 2020-10-15
MX2024007688A (es) 2024-07-09
US11242373B2 (en) 2022-02-08
ES2925678T3 (es) 2022-10-19
PL3774862T3 (pl) 2022-10-03
PE20211417A1 (es) 2021-08-02
AU2025242190A1 (en) 2025-10-23
ECSP20070185A (es) 2021-01-29
CY1125528T1 (el) 2026-02-25
US11873328B2 (en) 2024-01-16
US12421289B2 (en) 2025-09-23
EP4364751A2 (en) 2024-05-08
LT4122954T (lt) 2024-06-25
US11485766B2 (en) 2022-11-01
US20190309040A1 (en) 2019-10-10
US20210206823A1 (en) 2021-07-08
SMT202400241T1 (it) 2024-07-09
HRP20221054T1 (hr) 2022-11-11
HUE060135T2 (hu) 2023-02-28
DK3774862T3 (da) 2022-09-05
US20220402991A1 (en) 2022-12-22
EP4364751A3 (en) 2024-06-26

Similar Documents

Publication Publication Date Title
SI3774862T1 (sl) Novi analogi GLP-1
IL292753A (en) Compounds
EP3836923A4 (en) PYRROLO-DIPYRIDINE COMPOUNDS
MA52948A (fr) Composés
MA51669A (fr) Composés
DK3810587T3 (da) Substituerede alkoxypyridinylindolsulfonamider
MA53003A (fr) Composés
EP4007967A4 (en) Multiply-accumulate unit
EP3930851A4 (en) COMBINATION THERAPIES
IL282330A (en) Therapeutic compounds
EP3967649C0 (en) LIPID NANOPARTICLE
EP3742771C0 (en) M2M SM-SR TO SM-DP NOTIFICATION
EP3893975A4 (en) RESPIRATORY INTERFACE
MA52946A (fr) Composés
EP3989891C0 (en) CRYOCABIN LAYOUT
EP3912517C0 (en) FRAME
LT3867247T (lt) Naujieji junginiai
IL283673A (en) Deuterated analogs of acetyl-leucine
EP3973348A4 (en) HEAD MOUNT DISPLAYS
EP3957391C0 (en) AGITATOR
EP4045120A4 (en) RESPIRATORY INTERFACE ASSEMBLY
EP3975220A4 (en) Display panel
EP3965638C0 (en) VAGINAL SPECULUM
EP3962498A4 (en) Combination therapies
EP3902806C0 (en) THIENOPYRIDINONE COMPOUNDS