ECSP20070185A - Análogos novedosos de glp-1 - Google Patents
Análogos novedosos de glp-1Info
- Publication number
- ECSP20070185A ECSP20070185A ECSENADI202070185A ECDI202070185A ECSP20070185A EC SP20070185 A ECSP20070185 A EC SP20070185A EC SENADI202070185 A ECSENADI202070185 A EC SENADI202070185A EC DI202070185 A ECDI202070185 A EC DI202070185A EC SP20070185 A ECSP20070185 A EC SP20070185A
- Authority
- EC
- Ecuador
- Prior art keywords
- analogs
- glp
- action
- new
- present disclosure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Transmission And Conversion Of Sensor Element Output (AREA)
Abstract
La presente descripción se refiere a análogos novedosos del péptido similar al glucagón-1 (GLP-1) (7-37) que tienen una secuencia de aminoácidos con Leu o Ile en el C-terminal. Los nuevos análogos son potentes agonistas de GLP-1 con efecto adverso reducido y duración de la acción mejorada. La presente descripción se refiere además a derivados acilados de los nuevos análogos que tienen una potencia y duración de la acción mejoradas adicionalmente y son adecuados para la administración oral. Los análogos de la presente descripción pueden ser útiles en el tratamiento de la diabetes y la obesidad.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN201821013109 | 2018-04-05 | ||
IN201821040468 | 2018-10-26 | ||
IN201821040474 | 2018-10-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP20070185A true ECSP20070185A (es) | 2021-01-29 |
Family
ID=66589592
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ECSENADI202070185A ECSP20070185A (es) | 2018-04-05 | 2020-11-05 | Análogos novedosos de glp-1 |
Country Status (30)
Country | Link |
---|---|
US (6) | US11447535B2 (es) |
EP (3) | EP4122954B1 (es) |
JP (2) | JP7250814B2 (es) |
KR (1) | KR20200141469A (es) |
CN (2) | CN112236444A (es) |
AU (2) | AU2019247936C1 (es) |
BR (1) | BR112020020419A2 (es) |
CA (1) | CA3095988A1 (es) |
CL (1) | CL2020002574A1 (es) |
CO (1) | CO2020012425A2 (es) |
DK (2) | DK3774862T3 (es) |
EC (1) | ECSP20070185A (es) |
ES (1) | ES2925678T3 (es) |
FI (1) | FI4122954T3 (es) |
HR (1) | HRP20221054T1 (es) |
HU (1) | HUE060135T2 (es) |
IL (1) | IL277483A (es) |
JO (1) | JOP20200251A1 (es) |
LT (2) | LT4122954T (es) |
MX (1) | MX2020010505A (es) |
PE (1) | PE20211417A1 (es) |
PH (1) | PH12020551591A1 (es) |
PL (1) | PL3774862T3 (es) |
PT (2) | PT4122954T (es) |
RS (1) | RS63523B1 (es) |
SG (1) | SG11202009467YA (es) |
SI (1) | SI3774862T1 (es) |
UA (1) | UA128210C2 (es) |
WO (1) | WO2019193576A1 (es) |
ZA (1) | ZA202306729B (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20211417A1 (es) * | 2018-04-05 | 2021-08-02 | Sun Pharmaceutical Ind Ltd | Analogos novedosos de glp-1 |
TWI829687B (zh) | 2018-05-07 | 2024-01-21 | 丹麥商諾佛 儂迪克股份有限公司 | 包含glp-1促效劑與n-(8-(2-羥基苯甲醯基)胺基)辛酸之鹽的固體組成物 |
TW202216746A (zh) * | 2020-06-22 | 2022-05-01 | 印度商太陽製藥工業有限公司 | 長效型glp-1/gip雙重促效劑 |
BR112023003668A2 (pt) * | 2020-10-17 | 2023-04-25 | Sun Pharmaceutical Ind Ltd | Agonistas duplos de glp-1/gip |
CN114685646B (zh) * | 2020-12-31 | 2023-04-07 | 厦门赛诺邦格生物科技股份有限公司 | 一种多肽侧链类似物的制备方法及其应用 |
CA3204051A1 (en) | 2021-01-20 | 2022-07-28 | Brian Lian | Compositions and methods for the treatment of metabolic and liver disorders |
CN116514952B (zh) * | 2022-10-13 | 2024-02-02 | 江苏师范大学 | 一类glp-1类似物及其应用 |
CN117756914A (zh) * | 2023-12-15 | 2024-03-26 | 瀚晖制药有限公司 | 依柯胰岛素的制备方法 |
Family Cites Families (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6849708B1 (en) | 1986-05-05 | 2005-02-01 | The General Hospital Corporation | Insulinotropic hormone and uses thereof |
US6268343B1 (en) | 1996-08-30 | 2001-07-31 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
DE69737479T4 (de) | 1996-08-30 | 2010-05-06 | Novo Nordisk A/S | Glp-1 derivate |
WO1999043708A1 (en) | 1998-02-27 | 1999-09-02 | Novo Nordisk A/S | Glp-1 derivatives of glp-1 and exendin with protracted profile of action |
ATE466028T1 (de) | 1998-02-27 | 2010-05-15 | Novo Nordisk As | N-terminal veränderte glp-1 abkömmlinge |
JP2002508162A (ja) | 1998-02-27 | 2002-03-19 | ノボ ノルディスク アクティーゼルスカブ | N末端を短縮したglp−1誘導体 |
EP1060191B1 (en) | 1998-02-27 | 2010-04-28 | Novo Nordisk A/S | Derivatives of glp-1 analogs |
FR2777283B1 (fr) | 1998-04-10 | 2000-11-24 | Adir | Nouveaux composes peptidiques analogues du glucagon-peptide- 1 (7-37), leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
WO2000034331A2 (en) | 1998-12-07 | 2000-06-15 | Societe De Conseils De Recherches Et D'applications Scientifiques Sas | Analogues of glp-1 |
EP1294757B1 (en) | 2000-06-16 | 2006-11-22 | Eli Lilly And Company | Glucagon-like peptide-1 analogs |
HU230603B1 (hu) | 2000-12-07 | 2017-03-28 | Eli Lilly And Company | GLP1 fúziós fehérjék |
CA2468700A1 (en) | 2002-01-08 | 2003-07-17 | Eli Lilly And Company | Extended glucagon-like peptide-1 analogs |
US7291594B2 (en) | 2002-10-11 | 2007-11-06 | Sanwa Kagaku Kenkyusho Co., Ltd. | GLP-1 derivative and preparation thereof absorbable via mucous membrane |
WO2004078777A2 (en) | 2003-03-04 | 2004-09-16 | Biorexis Pharmaceutical Corporation | Dipeptidyl-peptidase protected proteins |
JP4699374B2 (ja) | 2003-05-15 | 2011-06-08 | トラスティーズ オブ タフツ カレッジ | 安定なペプチド及びポリペプチドアナログ治療剤 |
BR122019021416A2 (es) | 2003-09-19 | 2019-12-21 | ||
WO2005058955A1 (en) | 2003-12-16 | 2005-06-30 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. | Analogues of glp-1 |
EP1799710A2 (en) | 2004-10-07 | 2007-06-27 | Novo Nordisk A/S | Protracted glp-1 compounds |
US8603972B2 (en) | 2005-03-18 | 2013-12-10 | Novo Nordisk A/S | Extended GLP-1 compounds |
TWI372629B (en) | 2005-03-18 | 2012-09-21 | Novo Nordisk As | Acylated glp-1 compounds |
WO2006121860A2 (en) | 2005-05-06 | 2006-11-16 | Bayer Pharmaceuticals Corporation | Glucagon-like peptide 1 (glp-1) receptor agonists and their pharmacological methods of use |
US8318668B2 (en) | 2005-09-08 | 2012-11-27 | Trustees Of Tufts College | Stabilized GLP-1 analogs |
SI1767545T1 (sl) | 2005-09-22 | 2010-03-31 | Biocompatibles Uk Ltd | GLP Glukagonu podobni peptidi fuzijski polipeptidi s povečano rezistenco na peptidazo |
ES2532116T3 (es) | 2007-09-05 | 2015-03-24 | Novo Nordisk A/S | Péptidos derivados con A-B-C-D y sus usos terapéuticos |
WO2009058734A1 (en) | 2007-10-30 | 2009-05-07 | Indiana University Research And Technology Corporation | Compounds exhibiting glucagon antagonist and glp-1 agonist activity |
ES2625735T3 (es) | 2009-12-16 | 2017-07-20 | Novo Nordisk A/S | Análogos y derivados de GLP-1 |
AU2011247824B2 (en) | 2010-04-27 | 2014-02-13 | Betta Pharmaceuticals Co., Ltd | Glucagon-like peptide-1 analogue and use thereof |
WO2012016419A1 (zh) | 2010-08-06 | 2012-02-09 | 浙江贝达药业有限公司 | Glp-1衍生物及其应用 |
ES2683372T3 (es) | 2010-11-09 | 2018-09-26 | Novo Nordisk A/S | Derivados de GLP-1 acilados con un conector nuevo |
BR112013026195A2 (pt) | 2011-04-12 | 2016-11-29 | Novo Nordisk As | derivados de glp-1 duplamente acilados |
WO2012150503A2 (en) | 2011-05-03 | 2012-11-08 | Zealand Pharma A/S | Glu-glp-1 dual agonist signaling-selective compounds |
CN104039822A (zh) | 2011-09-06 | 2014-09-10 | 诺沃—诺迪斯克有限公司 | Glp-1衍生物 |
EP2578599A1 (en) | 2011-10-07 | 2013-04-10 | LanthioPep B.V. | Cyclic analogs of GLP-1 and GLP-1 related peptides |
EP2846824B1 (en) | 2012-05-08 | 2017-04-05 | Novo Nordisk A/S | Double-acylated glp-1 derivatives |
JP6250034B2 (ja) | 2012-05-08 | 2017-12-20 | ノヴォ ノルディスク アー/エス | 二重アシル化されたglp−1誘導体 |
AU2013276610A1 (en) | 2012-06-14 | 2015-01-15 | Sanofi | Exendin-4 peptide analogues |
UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
TWI674270B (zh) | 2012-12-11 | 2019-10-11 | 英商梅迪繆思有限公司 | 用於治療肥胖之升糖素與glp-1共促效劑 |
KR20150096398A (ko) | 2012-12-21 | 2015-08-24 | 사노피 | 이중 glp1/gip 또는 삼중 glp1/gip/글루카곤 작용제로서의 엑센딘-4 유도체 |
JP6475233B2 (ja) | 2013-06-20 | 2019-02-27 | ノヴォ ノルディスク アー/エス | Glp−1誘導体及びその使用 |
US9738697B2 (en) | 2013-06-23 | 2017-08-22 | Wisconsin Alumni Research Foundation | Alpha/beta-polypeptide analogs of glucagon-like peptide-1 |
US9498534B2 (en) | 2013-07-04 | 2016-11-22 | Novo Nordisk A/S | Derivatives of GLP-1 like peptides, and uses thereof |
EP3033112B1 (en) | 2013-08-15 | 2020-10-07 | Novo Nordisk A/S | Glp-1 derivatives, and uses thereof |
AR098065A1 (es) * | 2013-10-17 | 2016-04-27 | Zealand Pharma As | Análogos de glucagón acilados |
TW201609800A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 做為雙重glp-1/升糖素受體促效劑之艾塞那肽-4胜肽類似物 |
WO2015086733A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Dual glp-1/glucagon receptor agonists |
EP3415526A1 (en) | 2013-12-13 | 2018-12-19 | MedImmune Limited | Protease resistant peptides |
WO2016083499A1 (en) | 2014-11-27 | 2016-06-02 | Novo Nordisk A/S | Glp-1 derivatives and uses thereof |
WO2016097108A1 (en) | 2014-12-17 | 2016-06-23 | Novo Nordisk A/S | Glp-1 derivatives and uses thereof |
TWI726889B (zh) | 2015-06-10 | 2021-05-11 | 英商梅迪繆思有限公司 | 蛋白酶抗性之脂化肽 |
WO2017035432A1 (en) | 2015-08-26 | 2017-03-02 | Robert Doyle | Coagonists of glucagon-like peptide 1 receptor and neuropeptide y2 receptor |
EP3423481B1 (en) | 2016-03-03 | 2020-10-07 | Novo Nordisk A/S | Glp-1 derivatives and uses thereof |
KR20190017017A (ko) | 2016-06-09 | 2019-02-19 | 메디뮨 리미티드 | 프로테아제-내성 모노-지질화된 펩타이드 |
WO2018083335A1 (en) | 2016-11-07 | 2018-05-11 | Novo Nordisk A/S | Dchbs-active esters of peg compounds and their use |
TW201833131A (zh) | 2016-12-02 | 2018-09-16 | 法商賽諾菲公司 | 作為胜肽類glp1/升糖素/gip受體促效劑之新化合物 |
WO2018178796A1 (en) * | 2017-03-27 | 2018-10-04 | Sun Pharmaceutical Industries Limited | Method for making kex1 protease sensitive polypeptides using yeast strain |
PL3704143T3 (pl) | 2018-03-09 | 2024-04-15 | Fresenius Kabi Ipsum S.R.L. | Chemo-enzymatyczna synteza liraglutydu, semaglutydu i glp-1 |
PE20211417A1 (es) * | 2018-04-05 | 2021-08-02 | Sun Pharmaceutical Ind Ltd | Analogos novedosos de glp-1 |
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2019
- 2019-04-05 PE PE2020001535A patent/PE20211417A1/es unknown
- 2019-04-05 ES ES19724915T patent/ES2925678T3/es active Active
- 2019-04-05 DK DK19724915.4T patent/DK3774862T3/da active
- 2019-04-05 DK DK22177403.7T patent/DK4122954T3/da active
- 2019-04-05 US US16/376,190 patent/US11447535B2/en active Active
- 2019-04-05 MX MX2020010505A patent/MX2020010505A/es unknown
- 2019-04-05 CN CN201980037166.1A patent/CN112236444A/zh active Pending
- 2019-04-05 BR BR112020020419-6A patent/BR112020020419A2/pt unknown
- 2019-04-05 AU AU2019247936A patent/AU2019247936C1/en active Active
- 2019-04-05 PL PL19724915.4T patent/PL3774862T3/pl unknown
- 2019-04-05 KR KR1020207031696A patent/KR20200141469A/ko active Search and Examination
- 2019-04-05 EP EP22177403.7A patent/EP4122954B1/en active Active
- 2019-04-05 HR HRP20221054TT patent/HRP20221054T1/hr unknown
- 2019-04-05 HU HUE19724915A patent/HUE060135T2/hu unknown
- 2019-04-05 WO PCT/IB2019/052835 patent/WO2019193576A1/en active Application Filing
- 2019-04-05 CA CA3095988A patent/CA3095988A1/en active Pending
- 2019-04-05 LT LTEP22177403.7T patent/LT4122954T/lt unknown
- 2019-04-05 PT PT221774037T patent/PT4122954T/pt unknown
- 2019-04-05 EP EP24161843.8A patent/EP4364751A3/en active Pending
- 2019-04-05 UA UAA202006178A patent/UA128210C2/uk unknown
- 2019-04-05 SI SI201930322T patent/SI3774862T1/sl unknown
- 2019-04-05 EP EP19724915.4A patent/EP3774862B1/en active Active
- 2019-04-05 SG SG11202009467YA patent/SG11202009467YA/en unknown
- 2019-04-05 RS RS20220814A patent/RS63523B1/sr unknown
- 2019-04-05 PT PT197249154T patent/PT3774862T/pt unknown
- 2019-04-05 JO JOP/2020/0251A patent/JOP20200251A1/ar unknown
- 2019-04-05 FI FIEP22177403.7T patent/FI4122954T3/fi active
- 2019-04-05 JP JP2020553627A patent/JP7250814B2/ja active Active
- 2019-04-05 CN CN202311777728.0A patent/CN117964735A/zh active Pending
- 2019-04-05 LT LTEPPCT/IB2019/052835T patent/LT3774862T/lt unknown
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2020
- 2020-08-04 US US16/985,207 patent/US11242373B2/en active Active
- 2020-09-21 IL IL277483A patent/IL277483A/en unknown
- 2020-09-29 PH PH12020551591A patent/PH12020551591A1/en unknown
- 2020-10-02 CO CONC2020/0012425A patent/CO2020012425A2/es unknown
- 2020-10-05 CL CL2020002574A patent/CL2020002574A1/es unknown
- 2020-11-05 EC ECSENADI202070185A patent/ECSP20070185A/es unknown
- 2020-12-28 US US17/134,982 patent/US11485766B2/en active Active
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2022
- 2022-08-01 US US17/816,577 patent/US11873328B2/en active Active
- 2022-08-12 US US17/819,466 patent/US11866477B2/en active Active
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2023
- 2023-03-22 JP JP2023045498A patent/JP2023078367A/ja active Pending
- 2023-06-01 AU AU2023203430A patent/AU2023203430A1/en active Pending
- 2023-06-30 ZA ZA2023/06729A patent/ZA202306729B/en unknown
- 2023-11-21 US US18/515,712 patent/US20240199718A1/en active Pending
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