ECSP20070185A - Análogos novedosos de glp-1 - Google Patents

Análogos novedosos de glp-1

Info

Publication number
ECSP20070185A
ECSP20070185A ECSENADI202070185A ECDI202070185A ECSP20070185A EC SP20070185 A ECSP20070185 A EC SP20070185A EC SENADI202070185 A ECSENADI202070185 A EC SENADI202070185A EC DI202070185 A ECDI202070185 A EC DI202070185A EC SP20070185 A ECSP20070185 A EC SP20070185A
Authority
EC
Ecuador
Prior art keywords
analogs
glp
action
new
present disclosure
Prior art date
Application number
ECSENADI202070185A
Other languages
English (en)
Inventor
Ravishankara Madavati Nagaraja
Kunal Pandya
Abhishek Tiwari
Rishit Mansukhlal Zalawadia
Nishith Chaturvedi
Vinod Sampatrao Burade
Dhiren Rameshchandra Joshi
Vipulkumar Shankarbhai Pa-Tel
Brijeshkumar Patel
Pradeep Dinesh Shahi
Krunal Harishbhai Soni
Rajamannar Thennati
Muthukumaran Natarajan
Original Assignee
Sun Pharmaceutical Ind Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sun Pharmaceutical Ind Ltd filed Critical Sun Pharmaceutical Ind Ltd
Publication of ECSP20070185A publication Critical patent/ECSP20070185A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Immunology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Transmission And Conversion Of Sensor Element Output (AREA)

Abstract

La presente descripción se refiere a análogos novedosos del péptido similar al glucagón-1 (GLP-1) (7-37) que tienen una secuencia de aminoácidos con Leu o Ile en el C-terminal. Los nuevos análogos son potentes agonistas de GLP-1 con efecto adverso reducido y duración de la acción mejorada. La presente descripción se refiere además a derivados acilados de los nuevos análogos que tienen una potencia y duración de la acción mejoradas adicionalmente y son adecuados para la administración oral. Los análogos de la presente descripción pueden ser útiles en el tratamiento de la diabetes y la obesidad.
ECSENADI202070185A 2018-04-05 2020-11-05 Análogos novedosos de glp-1 ECSP20070185A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN201821013109 2018-04-05
IN201821040474 2018-10-26
IN201821040468 2018-10-26

Publications (1)

Publication Number Publication Date
ECSP20070185A true ECSP20070185A (es) 2021-01-29

Family

ID=66589592

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI202070185A ECSP20070185A (es) 2018-04-05 2020-11-05 Análogos novedosos de glp-1

Country Status (33)

Country Link
US (7) US11447535B2 (es)
EP (3) EP4364751A3 (es)
JP (2) JP7250814B2 (es)
KR (2) KR20250065720A (es)
CN (3) CN112236444B (es)
AU (3) AU2019247936C1 (es)
BR (1) BR112020020419A2 (es)
CA (1) CA3095988A1 (es)
CL (1) CL2020002574A1 (es)
CO (1) CO2020012425A2 (es)
DK (2) DK4122954T3 (es)
EC (1) ECSP20070185A (es)
ES (2) ES2980707T3 (es)
FI (1) FI4122954T3 (es)
HR (2) HRP20221054T1 (es)
HU (2) HUE060135T2 (es)
IL (1) IL277483B1 (es)
JO (1) JOP20200251A1 (es)
LT (2) LT4122954T (es)
MX (2) MX2020010505A (es)
MY (1) MY202560A (es)
NZ (1) NZ768446A (es)
PE (1) PE20211417A1 (es)
PH (1) PH12020551591A1 (es)
PL (2) PL3774862T3 (es)
PT (2) PT3774862T (es)
RS (2) RS65639B1 (es)
SG (1) SG11202009467YA (es)
SI (2) SI3774862T1 (es)
SM (2) SMT202200352T1 (es)
UA (1) UA128210C2 (es)
WO (1) WO2019193576A1 (es)
ZA (1) ZA202306729B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20221054T1 (hr) * 2018-04-05 2022-11-11 Sun Pharmaceutical Industries Limited Novi analozi glp-1
TWI829687B (zh) 2018-05-07 2024-01-21 丹麥商諾佛 儂迪克股份有限公司 包含glp-1促效劑與n-(8-(2-羥基苯甲醯基)胺基)辛酸之鹽的固體組成物
WO2020180534A1 (en) 2019-03-01 2020-09-10 President And Fellows Of Harvard College Methods and compositions for protein delivery
TW202216746A (zh) * 2020-06-22 2022-05-01 印度商太陽製藥工業有限公司 長效型ｇｌｐ－１／ｇｉｐ雙重促效劑
PE20231309A1 (es) * 2020-10-17 2023-08-24 Sun Pharmaceutical Ind Ltd Agonistas duales glp-1/gip
CN114685646B (zh) * 2020-12-31 2023-04-07 厦门赛诺邦格生物科技股份有限公司 一种多肽侧链类似物的制备方法及其应用
KR102691149B1 (ko) 2021-01-20 2024-08-05 바이킹 테라퓨틱스 인코포레이티드 대사 및 간 질환 치료를 위한 조성물 및 방법
EP4259647A4 (en) 2021-09-15 2025-03-26 Viking Therapeutics, Inc. COMPOSITIONS AND METHODS FOR THE TREATMENT OF METABOLIC AND LIVER DISEASES
MX2024005705A (es) 2021-11-10 2024-05-24 I2O Therapeutics Inc Composiciones de liquidos ionicos.
CN116514952B (zh) * 2022-10-13 2024-02-02 江苏师范大学 一类glp-1类似物及其应用
CN121263433A (zh) 2023-06-09 2026-01-02 太阳医药工业有限公司 Glp-1/gip双重、glp-1/gcg双重和glp-1/gip/gcg三重受体激动剂
WO2024261580A1 (en) 2023-06-20 2024-12-26 Sun Pharmaceutical Industries Limited Glp-1 analog for use in the treatment of metabolic disorders
CN117756914B (zh) * 2023-12-15 2024-09-03 瀚晖制药有限公司 依柯胰岛素的制备方法
WO2025163615A1 (en) 2024-01-31 2025-08-07 Sun Pharmaceutical Industries Ltd. High level production of glp1 analogues

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6849708B1 (en) 1986-05-05 2005-02-01 The General Hospital Corporation Insulinotropic hormone and uses thereof
RU2214419C2 (ru) 1996-08-30 2003-10-20 Ново Нордиск А/С Glp-1 производные
US6268343B1 (en) 1996-08-30 2001-07-31 Novo Nordisk A/S Derivatives of GLP-1 analogs
AU2610599A (en) 1998-02-27 1999-09-15 Novo Nordisk A/S N-terminally truncated glp-1 derivatives
AU3247799A (en) 1998-02-27 1999-09-15 Novo Nordisk A/S Glp-1 derivatives of glp-1 and exendin with protracted profile of action
AU2610699A (en) 1998-02-27 1999-09-15 Novo Nordisk A/S Derivatives of glp-1 analogs
ATE466028T1 (de) 1998-02-27 2010-05-15 Novo Nordisk As N-terminal veränderte glp-1 abkömmlinge
FR2777283B1 (fr) 1998-04-10 2000-11-24 Adir Nouveaux composes peptidiques analogues du glucagon-peptide- 1 (7-37), leur procede de preparation et les compositions pharmaceutiques qui les contiennent
ES2230912T3 (es) 1998-12-07 2005-05-01 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Analogo de glp-1.
US7084243B2 (en) 2000-06-16 2006-08-01 Eli Lilly And Company Glucagon-like peptide-1 analogs
NZ525577A (en) 2000-12-07 2005-05-27 Lilly Co Eli Glucagon-Like Peptide 1 heterologous fusion proteins for the treatment of non-insulin dependent diabetes mellitus
MXPA04006679A (es) 2002-01-08 2004-11-10 Lilly Co Eli Analogos extendidos de peptido-1 de tipo glucagon.
WO2004037859A1 (ja) 2002-10-11 2004-05-06 Sanwa Kagaku Kenkyusho Co., Ltd. Glp-1誘導体及びその経粘膜吸収型製剤
WO2004078777A2 (en) 2003-03-04 2004-09-16 Biorexis Pharmaceutical Corporation Dipeptidyl-peptidase protected proteins
CA2525574C (en) 2003-05-15 2015-06-30 Trustees Of Tufts College Stable analogs of peptide and polypeptide therapeutics
MXPA06002941A (es) 2003-09-19 2006-05-31 Novo Nordisk As Derivados de enlace a albumina de peptidos terapeuticos.
CA2551039C (en) 2003-12-16 2013-01-29 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R Analogues of glp-1
WO2006037810A2 (en) 2004-10-07 2006-04-13 Novo Nordisk A/S Protracted glp-1 compounds
CA2596926A1 (en) * 2005-03-18 2006-09-21 Novo Nordisk A/S Extended glp-1 compounds
TWI362392B (en) 2005-03-18 2012-04-21 Novo Nordisk As Acylated glp-1 compounds
CA2607566A1 (en) 2005-05-06 2006-11-16 Bayer Pharmaceuticals Corporation Glucagon-like peptide 1 (glp-1) receptor agonists and their pharmacological methods of use
US8318668B2 (en) 2005-09-08 2012-11-27 Trustees Of Tufts College Stabilized GLP-1 analogs
PL1767545T3 (pl) 2005-09-22 2010-04-30 Biocompatibles Uk Ltd Polipeptydy fuzyjne GLP-1 (glukagonopodobny peptyd-1) o zwiększonej odporności na peptydazy
CN101842109B (zh) 2007-09-05 2014-01-29 诺沃-诺迪斯克有限公司 用a-b-c-d-衍生的肽和它们的治疗用途
JP5771005B2 (ja) 2007-10-30 2015-08-26 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ グルカゴンアンタゴニスト及びｇｌｐ−１アゴニスト活性を示す化合物
JP5411366B2 (ja) 2009-12-16 2014-02-12 ノヴォ ノルディスク アー／エス 二重アシル化ｇｌｐ−１誘導体
CA2797431C (en) 2010-04-27 2016-06-21 Zhejiang Beta Pharma Inc. Glucagon-like peptide-1 analogue and use thereof
WO2012016419A1 (zh) 2010-08-06 2012-02-09 浙江贝达药业有限公司 Glp-1衍生物及其应用
EP2637698B1 (en) 2010-11-09 2022-04-20 Novo Nordisk A/S Double-acylated glp-1 derivatives
EP2696687B1 (en) 2011-04-12 2016-10-26 Novo Nordisk A/S Double-acylated glp-1 derivatives
WO2012150503A2 (en) 2011-05-03 2012-11-08 Zealand Pharma A/S Glu-glp-1 dual agonist signaling-selective compounds
JP6126097B2 (ja) 2011-09-06 2017-05-10 ノヴォ ノルディスク アー／エス Ｇｌｐ−１誘導体
EP2578599A1 (en) 2011-10-07 2013-04-10 LanthioPep B.V. Cyclic analogs of GLP-1 and GLP-1 related peptides
WO2013167454A1 (en) 2012-05-08 2013-11-14 Novo Nordisk A/S Double-acylated glp-1 derivatives
WO2013167455A1 (en) 2012-05-08 2013-11-14 Novo Nordisk A/S Double-acylated glp-1 derivatives
IN2014KN02830A (es) 2012-06-14 2015-05-08 Sanofi Sa
UA116217C2 (uk) 2012-10-09 2018-02-26 Санофі Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
TWI674270B (zh) 2012-12-11 2019-10-11 英商梅迪繆思有限公司 用於治療肥胖之升糖素與glp-1共促效劑
CA2895875A1 (en) 2012-12-21 2014-06-26 Sanofi Exendin-4 derivatives
ES2646538T3 (es) 2013-06-20 2017-12-14 Novo Nordisk A/S Derivados de GLP-1 y sus usos
US9738697B2 (en) 2013-06-23 2017-08-22 Wisconsin Alumni Research Foundation Alpha/beta-polypeptide analogs of glucagon-like peptide-1
BR112015032875A2 (pt) 2013-07-04 2017-11-07 Novo Nordisk As derivados de peptídeos do tipo glp-1, e usos dos mesmos
WO2015022400A1 (en) 2013-08-15 2015-02-19 Novo Nordisk A/S Glp-1 derivatives, and uses thereof
WO2015055801A1 (en) * 2013-10-17 2015-04-23 Zealand Pharma A/S Acylated glucagon analogues
WO2015086733A1 (en) 2013-12-13 2015-06-18 Sanofi Dual glp-1/glucagon receptor agonists
EP3080155A1 (en) 2013-12-13 2016-10-19 Sanofi Exendin-4 peptide analogues as dual glp-1/glucagon receptor agonists
BR112016013157A2 (pt) 2013-12-13 2017-09-26 Medimmune Ltd peptídeos resistentes à protease
ES2739289T3 (es) 2014-11-27 2020-01-30 Novo Nordisk As Derivados de GLP-1 y sus usos
US10392428B2 (en) 2014-12-17 2019-08-27 Novo Nordisk A/S GLP-1 derivatives and uses thereof
TWI726889B (zh) 2015-06-10 2021-05-11 英商梅迪繆思有限公司 蛋白酶抗性之脂化肽
US10111932B2 (en) 2015-08-26 2018-10-30 Syracuse University Coagonists of glucagon-like peptide 1 receptor and neuropeptide Y2 receptor
WO2017149070A1 (en) 2016-03-03 2017-09-08 Novo Nordisk A/S Glp-1 derivatives and uses thereof
AU2017277594A1 (en) 2016-06-09 2019-02-07 Medimmune Limited Protease-resistant mono-lipidated peptides
JP7076442B2 (ja) 2016-11-07 2022-05-27 ノヴォ ノルディスク アー／エス Ｐｅｇ化合物のｄｃｈｂｓ活性エステル及びその使用
TW201833131A (zh) 2016-12-02 2018-09-16 法商賽諾菲公司 作為胜肽類ｇｌｐ１／升糖素／ｇｉｐ受體促效劑之新化合物
WO2018178796A1 (en) * 2017-03-27 2018-10-04 Sun Pharmaceutical Industries Limited Method for making kex1 protease sensitive polypeptides using yeast strain
US10883132B2 (en) 2018-03-09 2021-01-05 Enzypep B.V. Chemo-enzymatic synthesis of Semaglutide, Liraglutide and GLP-1
HRP20221054T1 (hr) * 2018-04-05 2022-11-11 Sun Pharmaceutical Industries Limited Novi analozi glp-1

Also Published As

Publication number Publication date
SI3774862T1 (sl) 2022-10-28
US20220402991A1 (en) 2022-12-22
PE20211417A1 (es) 2021-08-02
ES2980707T3 (es) 2024-10-02
EP3774862B1 (en) 2022-06-08
US20240376175A1 (en) 2024-11-14
IL277483B1 (en) 2026-01-01
UA128210C2 (uk) 2024-05-08
HUE060135T2 (hu) 2023-02-28
BR112020020419A2 (pt) 2021-01-19
KR102801994B1 (ko) 2025-04-30
PH12020551591A1 (en) 2021-08-16
AU2019247936C1 (en) 2023-06-15
CN117964735A (zh) 2024-05-03
DK3774862T3 (da) 2022-09-05
US20190309040A1 (en) 2019-10-10
AU2025242190A1 (en) 2025-10-23
US20210206823A1 (en) 2021-07-08
HRP20221054T1 (hr) 2022-11-11
EP3774862A1 (en) 2021-02-17
KR20250065720A (ko) 2025-05-13
KR20200141469A (ko) 2020-12-18
HUE067499T2 (hu) 2024-10-28
RS65639B1 (sr) 2024-07-31
US20220402992A1 (en) 2022-12-22
US11485766B2 (en) 2022-11-01
MX2020010505A (es) 2021-01-15
SI4122954T1 (sl) 2024-07-31
EP4122954B1 (en) 2024-04-03
LT3774862T (lt) 2022-09-12
IL277483A (en) 2020-11-30
JP2023078367A (ja) 2023-06-06
CN112236444A (zh) 2021-01-15
JOP20200251A1 (ar) 2020-10-04
HRP20240749T1 (hr) 2024-09-13
US11866477B2 (en) 2024-01-09
AU2019247936A1 (en) 2020-10-15
EP4122954A1 (en) 2023-01-25
US11873328B2 (en) 2024-01-16
SMT202200352T1 (it) 2022-09-14
RS63523B1 (sr) 2022-09-30
JP7250814B2 (ja) 2023-04-03
JP2021520346A (ja) 2021-08-19
US12421289B2 (en) 2025-09-23
PT4122954T (pt) 2024-06-05
AU2023203430A1 (en) 2023-06-29
AU2023203430B2 (en) 2025-07-03
CL2020002574A1 (es) 2021-06-04
CN120554480A (zh) 2025-08-29
US11447535B2 (en) 2022-09-20
CO2020012425A2 (es) 2020-12-21
SG11202009467YA (en) 2020-10-29
FI4122954T3 (fi) 2024-06-18
ES2925678T3 (es) 2022-10-19
AU2019247936B2 (en) 2023-03-02
CA3095988A1 (en) 2019-10-10
CN112236444B (zh) 2025-09-19
WO2019193576A1 (en) 2019-10-10
MY202560A (en) 2024-05-08
PT3774862T (pt) 2022-09-05
PL4122954T3 (pl) 2024-08-12
ZA202306729B (en) 2024-03-27
LT4122954T (lt) 2024-06-25
NZ768446A (en) 2025-10-31
US11242373B2 (en) 2022-02-08
PL3774862T3 (pl) 2022-10-03
US20240199718A1 (en) 2024-06-20
MX2024007688A (es) 2024-07-09
SMT202400241T1 (it) 2024-07-09
US20200362007A1 (en) 2020-11-19
DK4122954T3 (da) 2024-06-10
EP4364751A3 (en) 2024-06-26
EP4364751A2 (en) 2024-05-08

Similar Documents

Publication Publication Date Title
ECSP20070185A (es) Análogos novedosos de glp-1
PE20170954A1 (es) Compuestos co-agonistas de gip y glp-1
MX2021000793A (es) Compuestos coagonistas de gip/glp1.
AR067555A1 (es) Derivado de peptido insulinotropico en el cual se modifica su aminoacido n- terminal
SA521431209B1 (ar) مواد مساعدة لمستقبل الببتيد الشبيه بالجلوكاجون 1
CO2019005924A2 (es) Agonistas duales acilados de glp-1/glp-2
ECSP19046893A (es) Nuevos compuestos como agonistas peptídicos trigonales de los receptores de glp1/glucagón/gip
MX421668B (es) Derivado de péptido-1 (glp-1) similar al glucagón acilado
AR099975A1 (es) Derivados de exendina-4 como agonistas peptídicos duales del receptor de glp-1 / glucagón
PE20151770A1 (es) Compuesto peptidico
PE20200606A1 (es) Composiciones solidas para administracion oral
RU2011129784A (ru) Основанные на амидах пролекарства пептидов глюкагонового надсемейства
AR094181A1 (es) Agonistas duales de glp1/gip o trigonales de glp1/gip/glucagon
PE20170087A1 (es) Composicion para tratar la diabetes mellitus, que comprende insulina y un agonista doble de glp-1/glucagon
PE20100255A1 (es) Co-agonistas del receptor de glucagon/glp-1
PE20221518A1 (es) Analogos de incretina y sus usos
CL2020002718A1 (es) Conjugados del péptido de fusión péptido similar al glucagón 1 (glp-1) acoplado al péptido tirosina tirosina cíclico y usos de estos.
AR128464A1 (es) Péptidos agonistas duales glp-1 y glucagón con estabilidad biológica mejorada
AR094358A1 (es) Derivados de péptidos insulinotrópicos cuya carga n-terminal está modificada
AR131483A1 (es) Agonista triple novedoso del receptor de glp-1 / gip / glucagón y una composición farmacéutica para prevenir o tratar la obesidad que lo comprende
TH2001005828A (th) Glp-1 อนาล็อกชนิดใหม่
EA202092017A1 (ru) Новые аналоги glp-1
AR125905A1 (es) Agonistas del receptor del péptido-1 similar al glucagón
NZ771617A (en) Glucagon derivatives
RU2011131714A (ru) Аналоги glp-1 и их использования