SG10201805039UA - Protease resistant peptides - Google Patents

Protease resistant peptides

Info

Publication number
SG10201805039UA
SG10201805039UA SG10201805039UA SG10201805039UA SG10201805039UA SG 10201805039U A SG10201805039U A SG 10201805039UA SG 10201805039U A SG10201805039U A SG 10201805039UA SG 10201805039U A SG10201805039U A SG 10201805039UA SG 10201805039U A SG10201805039U A SG 10201805039UA
Authority
SG
Singapore
Prior art keywords
peptides
protease
resistant peptides
protease resistant
resistant
Prior art date
Application number
SG10201805039UA
Inventor
Jefferson Revell
Maria Bednarek
Original Assignee
Medimmune Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medimmune Ltd filed Critical Medimmune Ltd
Publication of SG10201805039UA publication Critical patent/SG10201805039UA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/605—Glucagons

Abstract

The present invention provides protease-resistant peptides, methods of making such peptides, as well as compositions comprising protease-resistant peptides and method of treatment utilizing such peptides. Incorporation of alpha-methyl-functionalized amino acids directly into the main chain during standard peptide synthesis via the methodologies described herein has been determined to produce protease-resistant peptides. [FIG. 1]
SG10201805039UA 2013-12-13 2014-12-10 Protease resistant peptides SG10201805039UA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361915662P 2013-12-13 2013-12-13

Publications (1)

Publication Number Publication Date
SG10201805039UA true SG10201805039UA (en) 2018-07-30

Family

ID=52021207

Family Applications (1)

Application Number Title Priority Date Filing Date
SG10201805039UA SG10201805039UA (en) 2013-12-13 2014-12-10 Protease resistant peptides

Country Status (11)

Country Link
US (1) US20160318987A1 (en)
EP (2) EP3080153A2 (en)
JP (1) JP2017502003A (en)
KR (1) KR20160098406A (en)
CN (1) CN105849123A (en)
AU (1) AU2014363547A1 (en)
BR (1) BR112016013157A2 (en)
CA (1) CA2933405A1 (en)
MX (1) MX2016007407A (en)
SG (1) SG10201805039UA (en)
WO (1) WO2015086686A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI726889B (en) 2015-06-10 2021-05-11 英商梅迪繆思有限公司 Protease-resistant lipidated peptides
US20190055279A1 (en) * 2015-10-28 2019-02-21 Tufts University Novel polypeptides with improved proteolytic stability, and methods of preparing and using same
WO2017211922A2 (en) 2016-06-09 2017-12-14 Medimmune Limited Protease-resistant mono-lipidated peptides
EP3681900A4 (en) 2017-09-11 2021-09-08 Protagonist Therapeutics, Inc. Opioid agonist peptides and uses thereof
PE20211417A1 (en) 2018-04-05 2021-08-02 Sun Pharmaceutical Ind Ltd NEW GLP-1 ANALOGS
TW202346323A (en) * 2022-02-07 2023-12-01 英商梅迪繆思有限公司 Glp-1 and glucagon dual agonist peptides with improved biological stability

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL143346A0 (en) * 1998-12-07 2002-04-21 Sod Conseils Rech Applic Analogues of glp-1
US8445433B2 (en) * 2006-02-08 2013-05-21 Lonza Ag Synthesis of glucagon-like peptide
WO2007139589A1 (en) * 2006-05-26 2007-12-06 Bristol-Myers Squibb Company Sustained release glp-1 receptor modulators
WO2008023050A1 (en) * 2006-08-25 2008-02-28 Novo Nordisk A/S Acylated exendin-4 compounds
ATE554098T1 (en) * 2007-12-11 2012-05-15 Cadila Healthcare Ltd PEPTIDOMIMETICA WITH GLUCAGON ANTAGONIST AND GLP-1 AGONIST ACTIVITIES
ES2354488T3 (en) * 2008-04-18 2011-03-15 F. Hoffmann-La Roche Ag ALFA-N-METHYLATION OF AMINO ACIDS.
US20120264685A1 (en) * 2009-10-22 2012-10-18 Rajesh Bahekar Short chain peptidomimetics based orally active glp 1 agonist and glucagon receptor antagonist
US20130143800A1 (en) * 2011-11-07 2013-06-06 Research Development Foundation Combination therapies to treat diabetes
WO2014049610A2 (en) * 2012-09-26 2014-04-03 Cadila Healthcare Limited Peptides as gip, glp-1 and glucagon receptors triple-agonist
WO2014088631A1 (en) * 2012-12-06 2014-06-12 Stealth Peptides International, Inc. Peptide therapeutics and methods for using same

Also Published As

Publication number Publication date
WO2015086686A3 (en) 2015-10-29
CA2933405A1 (en) 2015-06-18
AU2014363547A1 (en) 2016-06-30
US20160318987A1 (en) 2016-11-03
BR112016013157A2 (en) 2017-09-26
WO2015086686A2 (en) 2015-06-18
EP3080153A2 (en) 2016-10-19
KR20160098406A (en) 2016-08-18
MX2016007407A (en) 2016-12-12
JP2017502003A (en) 2017-01-19
CN105849123A (en) 2016-08-10
EP3415526A1 (en) 2018-12-19

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